Metabolism, Aging and Disease

iMito: Integrative mitochondrial profiling

Mitochondria

Metabolism

Predictive Toxicology

Oxidative Stress

Preclinical Screenings


Research lines

MitoScreening: Profiling of mitochondrial health biomarkers

Predictive Toxicology: Profiling of mitochondrial health and redox modulators

Precision Redox: Improving preclinical screening of redox-active agents

Overview

Mitochondria are central organelles in cell biology and their dysfunction is associated with many diseases. Our group looks at mitochondrial physiology in an integrative way to characterize mitochondrial profiles associated with mitochondrial health and disease, with the final goal of validating innovative therapeutic strategies to improve cellular health. We intend to have an innovative and interdisciplinary vision that fosters synergies and stimulates the integration of different interdisciplinary views and techniques. We apply experimental cell biology techniques, including cell culture, cellular respirometry, high-content microscopy, quantitative PCR, western blotting, fluorimetry, spectrophotometry and luminometry. We also rely on a constant cross-talk with computational biologists and data scientists at the CNC and UC, to model and understand metabolic and redox fluxes and to explore experimental datasets in order to uncover hidden patterns in the data. We are also interested in the translation of academic knowledge and the development of a service facility associated with Predictive Mitochondrial Toxicology (MitoXT services).

Featured Articles

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Statins prevent beta-amyloid-induced toxicity in cortical neurons

Pereira, Cláudia; Fonseca, Ana Catarina Ribeiro da Graça; Resende, Rosa; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, C. M. F.; Fonseca, A. C.; et al, 2009. Journal of the Neurological Sciences. 281 - 281. 1. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400203&KeyUID=WOS:000268609400203 . 10.1016/j.jns.2009.02.159 . published Journal of the Neurological Sciences

Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons

Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho, 2011. Journal of Neurodegenerative Disorders. Supplement. 1. 2011. published Journal of Neurodegenerative Disorders

Occurrence of mcr-1 in Escherichia coli from rabbits of intensive farming

Freitas-Silva, Joana; Inácio, Ângela S.; Mourão, Joana; Antunes, Patrícia; Mendes, Ângelo; de Carvalho, André Pinto; Vasconcelos, Vitor; Peixe, Luísa; da Costa, Paulo Martins, 2018. Veterinary Microbiology. 78 - 81. 227. 2018. http://dx.doi.org/10.1016/j.vetmic.2018.10.020 . 10.1016/j.vetmic.2018.10.020 . published Veterinary Microbiology

Discrimination of non-typhoid Salmonella serogroups and serotypes by Fourier Transform Infrared Spectroscopy: A comprehensive analysis

Campos, Joana; Sousa, Clara; Mourão, Joana; Lopes, João; Antunes, Patrícia; Peixe, Luísa, 2018. International Journal of Food Microbiology. 34 - 41. 285. 2018. http://dx.doi.org/10.1016/j.ijfoodmicro.2018.07.005 . 10.1016/j.ijfoodmicro.2018.07.005 . published International Journal of Food Microbiology

Leakage of emerging clinically relevant multidrug-resistant Salmonella clones from pig farms

Antunes, Patrícia; Mourão, Joana; Pestana, Nazaré; Peixe, Luísa Vieira, 2011. Journal of Antimicrobial Chemotherapy. 2028 - 2032. 9. 66. 2011. http://dx.doi.org/10.1093/jac/dkr228 . 10.1093/jac/dkr228 . published Journal of Antimicrobial Chemotherapy


Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, 2021. Redox Biology. 2021. http://dx.doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . published Redox Biology

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Pereira, Susana P.; Tavares, Ludgero C.; Duarte, Ana I.; Baldeiras, Inês; Cunha-Oliveira, Teresa; Martins, João D.; Santos, Maria S.; et al, 2021. Clinical Science. 1103 - 1126. 9. 135. 2021. http://dx.doi.org/10.1042/cs20201339 . 10.1042/cs20201339 . published Clinical Science

Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Costa, C. F.; Pinho, S.A.; Pinho, S. L.; Miranda-Santos, I.; Bagshaw, O.; Stuart, J.; Oliveira, P.J.; # Cunha-Oliveira, T., 2021. BioRxiv. 2021. https://www.biorxiv.org/content/10.1101/2021.02.24.432508v1 . 10.1101/2021.02.24.432508 . published BioRxiv

MPV17 mutations are associated with a quiescent energetic metabolic profile

Jacinto, Sandra; Guerreiro. Patrícia; Machado de Oliveira, Rita; Cunha-Oliveira, T.; Santos, Maria João; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago, 2021. Frontiers in Cellular Neuroscience. 2021. https://www.frontiersin.org/articles/10.3389/fncel.2021.641264/abstract . published Frontiers in Cellular Neuroscience

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Simões, Rui F.; Ferrão, Rafaela; Silva, Margarida R.; Pinho, Sonia L. C.; Ferreira, Lino; Oliveira, Paulo J.; # Cunha-Oliveira, T., 2021. Food and Chemical Toxicology. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . published Food and Chemical Toxicology

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Cunha-Oliveira, Teresa; Montezinho, Liliana; Mendes, Catarina; Firuzi, Omidreza; Saso, Luciano; Oliveira, Paulo J.; Silva, Filomena S. G., 2020. Oxidative Medicine and Cellular Longevity. 1 - 29. 2020. 2020. http://dx.doi.org/10.1155/2020/5021694 . 10.1155/2020/5021694 . published Oxidative Medicine and Cellular Longevity

Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity

Serafim, Teresa L.; * Cunha-Oliveira, Teresa; Deus, Claudia M.; Sardão, Vilma A.; Cardoso, Ines M.; Yang, Shanshan; Odhiambo, John F.; et al, 2020. European Journal of Clinical Investigation. 2. 51. 2020. http://dx.doi.org/10.1111/eci.13375 . 10.1111/eci.13375 . published European Journal of Clinical Investigation

Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

Ferreira, Luciana L.; Cunha-Oliveira, Teresa; Veloso, Caroline D.; Costa, Cláudio F.; Wallace, Kendall B.; Oliveira, Paulo J., 2019. Food and Chemical Toxicology. 450 - 461. 124. 2019. http://dx.doi.org/10.1016/j.fct.2018.12.017 . 10.1016/j.fct.2018.12.017 . published Food and Chemical Toxicology

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; et al, 2019. Cell Metabolism. 399 - 416.e10. 2. 29. 2019. http://dx.doi.org/10.1016/j.cmet.2018.10.014 . 10.1016/j.cmet.2018.10.014 . published Cell Metabolism

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease

Valdinocci, Dario; Simões, Rui F.; Kovarova, Jaromira; Cunha-Oliveira, Teresa; Neuzil, Jiri; Pountney, Dean L., 2019. Frontiers in Neuroscience. 13. 2019. http://dx.doi.org/10.3389/fnins.2019.00930 . 10.3389/fnins.2019.00930 . Frontiers in Neuroscience

Doxorubicin persistently rewires cardiac circadian homeostasis in mice

Ferreira, Luciana L.; Cervantes, Marlene; Froufe, Hugo J. C.; Egas, Conceição; Cunha-Oliveira, Teresa; Sassone-Corsi, Paolo; Oliveira, Paulo J., 2019. Archives of Toxicology. 2019. http://dx.doi.org/10.1007/s00204-019-02626-z . 10.1007/s00204-019-02626-z . published Archives of Toxicology

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress

Ferreira, Leonardo M. R.; Cunha-Oliveira, Teresa; Sobral, Margarida C.; Abreu, Patrícia L.; Alpoim, Maria Carmen; Urbano, Ana M., 2019. International Journal of Molecular Sciences. 19. 20. 2019. http://dx.doi.org/10.3390/ijms20194901 . 10.3390/ijms20194901 . published International Journal of Molecular Sciences

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity

Pereira, Susana P; Deus, Cláudia M; Serafim, Teresa L; Cunha-Oliveira, Teresa; Oliveira, Paulo J, 2018. Toxicological Sciences. 191 - 204. 1. 164. 2018. http://dx.doi.org/10.1093/toxsci/kfy068 . 10.1093/toxsci/kfy068 . published Toxicological Sciences

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes

# Teresa Cunha-Oliveira; Luciana L. Ferreira; Ana Raquel Coelho; Cláudia M. Deus; Paulo J. Oliveira, 2018. Toxicology and Applied Pharmacology. 1 - 13. 348. 2018. https://doi.org/10.1016/j.taap.2018.04.009 . 10.1016/j.taap.2018.04.009 . published Toxicology and Applied Pharmacology

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells

Abreu, Patrícia L.; Cunha-Oliveira, Teresa; Ferreira, Leonardo M. R.; Urbano, Ana M., 2018. BioMetals. 477 - 487. 4. 31. 2018. http://dx.doi.org/10.1007/s10534-018-0093-7 . 10.1007/s10534-018-0093-7 . published BioMetals

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Naia, Luana; * Cunha-Oliveira, Teresa; Rodrigues, Joana; Rosenstock, Tatiana R.; Oliveira, Ana; Ribeiro, Márcio; Carmo, Catarina; et al, 2017. The Journal of Neuroscience. 2776 - 2794. 10. 37. 2017. http://dx.doi.org/10.1523/jneurosci.2006-14.2016 . 10.1523/JNEUROSCI.2006-14.2016 . published The Journal of Neuroscience

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts

Coelho, Ana R.; Martins, Tatiana R.; Couto, Renata; Deus, Cláudia; Pereira, Cláudia V.; Simões, Rui F.; Rizvanov, Albert A.; et al, 2017. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2904 - 2923. 11. 1863. 2017. http://dx.doi.org/10.1016/j.bbadis.2017.07.030 . 10.1016/j.bbadis.2017.07.030 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, André; * Cunha-Oliveira, Teresa; Simões, Rui F.; Carvalho, Filipa S.; Burgeiro, Ana; Nordgren, Kendra; Wallace, Kendall B.; Oliveira, Paulo J., 2017. Toxicology. 63 - 73. 390. 2017. http://dx.doi.org/10.1016/j.tox.2017.08.011 . 10.1016/j.tox.2017.08.011 . published Toxicology

Ketogenic diets: from cancer to mitochondrial diseases and beyond

Branco, Ana F.; Ferreira, André; Simões, Rui F.; Magalhães-Novais, Sílvia; Zehowski, Cheryl; Cope, Elisabeth; Silva, Ana Marta; et al, 2016. European Journal of Clinical Investigation. 285 - 298. 3. 46. 2016. http://dx.doi.org/10.1111/eci.12591 . 10.1111/eci.12591 . published European Journal of Clinical Investigation

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, Ana Marta; Barbosa, Inês A.; Seabra, Cátia; Beltrão, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; # Cunha-Oliveira, Teresa, 2016. Food and Chemical Toxicology. 148 - 158. 1. 94. 2016. http://dx.doi.org/10.1016/j.fct.2016.06.001 . 10.1016/j.fct.2016.06.001 . published Food and Chemical Toxicology

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Naia, Luana; Ferreira, I. Luísa; Cunha-Oliveira, Teresa; Duarte, Ana I.; Ribeiro, Márcio; Rosenstock, Tatiana R.; Laço, Mário N.; et al, 2015. Molecular Neurobiology. 331 - 348. 1. 51. 2015. http://dx.doi.org/10.1007/s12035-014-8735-4 . 10.1007/s12035-014-8735-4 . published Molecular Neurobiology

Role of mtDNA-related mitoepigenetic phenomena in cancer

Ferreira, André; Serafim, Teresa L; Sardão, Vilma A; # Cunha-Oliveira, Teresa, 2015. European Journal of Clinical Investigation. 44 - 49. S1. 45. 2015. http://dx.doi.org/10.1111/eci.12359 . 10.1111/eci.12359 . published European Journal of Clinical Investigation

ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco, Ana F; Moreira, Ana C; Cunha-Oliveira, Teresa; Couto, Renata; Sardao, Vilma A; Rizvanov, Albert A; Palotas, Andras; et al, 2014. Current Drug Targets. 956 - 964. 10. 15. 2014. http://dx.doi.org/10.2174/1389450115666140902124230 . 10.2174/1389450115666140902124230 . published Current Drug Targets

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts

Moreira, Ana C; Branco, Ana F; Sampaio, Susana F; Cunha-Oliveira, Teresa; Martins, Tatiana R; Holy, Jon; Oliveira, Paulo J; et al, 2014. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2468 - 2478. 12. 1842. 2014. http://hdl.handle.net/10316/41109 . 10.1016/j.bbadis.2014.09.015 . published Biochimica et Biophysica Acta-Molecular Basis of Disease

Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., 2013. Toxicology Letters. 298 - 306. 3. 219. 2013. http://dx.doi.org/10.1016/j.toxlet.2013.03.025 . 10.1016/j.toxlet.2013.03.025 . published Toxicology Letters

Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., 2013. Life Sciences. 1157 - 1164. 24-26. 92. 2013. http://dx.doi.org/10.1016/j.lfs.2013.04.016 . 10.1016/j.lfs.2013.04.016 . published Life Sciences

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition

Bernardo, Telma C.; Cunha-Oliveira, Teresa; Serafim, Teresa L.; Holy, Jon; Krasutsky, Dmytro; Kolomitsyna, Oksana; Krasutsky, Pavel; Moreno, António M.; Oliveira, Paulo J., 2013. Bioorganic & Medicinal Chemistry. 7239 - 7249. 23. 21. 2013. http://dx.doi.org/10.1016/j.bmc.2013.09.066 . 10.1016/j.bmc.2013.09.066 . published Bioorganic & Medicinal Chemistry

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, Rita; * Cunha-Oliveira, Teresa; Rego, Ana Cristina, 2013. Free Radical Biology and Medicine. 186 - 201. 62. 2013. http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.042 . 10.1016/j.freeradbiomed.2013.05.042 . published Free Radical Biology and Medicine

Oxidative Stress and Drugs of Abuse: An Update

# Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R., 2013. Mini-Reviews in Organic Chemistry. 321 - 334. 4. 10. 2013. http://dx.doi.org/10.2174/1570193X113106660026 . 10.2174/1570193X113106660026 . published Mini-Reviews in Organic Chemistry

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse

Perfeito, R.; * Cunha-Oliveira, T.; Rego, A.C., 2012. Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867397192&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.08.569 . Free Radical Biology and Medicine

Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice

Pereira, Frederico C.; Cunha-Oliveira, Teresa; Viana, Sofia D.; Travassos, Ana S.; Nunes, Sara; Silva, Carlos; Prediger, Rui Daniel; et al, 2012. Neurotoxicology and Teratology. 522 - 529. 5. 34. 2012. http://dx.doi.org/10.1016/j.ntt.2012.07.005 . 10.1016/j.ntt.2012.07.005 . published Neurotoxicology and Teratology

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

Ribeiro, Márcio; Rosenstock, Tatiana R.; Cunha-Oliveira, Teresa; Ferreira, Ildete L.; Oliveira, Catarina R.; Rego, A. Cristina, 2012. Free Radical Biology and Medicine. 1857 - 1867. 10. 53. 2012. http://dx.doi.org/10.1016/j.freeradbiomed.2012.09.004 . 10.1016/j.freeradbiomed.2012.09.004 . published Free Radical Biology and Medicine

Bioenergetic dysfunction in Huntington's disease human cybrids

Ferreira, I. Luisa; * Cunha-Oliveira, Teresa; Nascimento, Maria V.; Ribeiro, Márcio; Proença, M. Teresa; Januário, Cristina; Oliveira, Catarina R.; Rego, A. Cristina, 2011. Experimental Neurology. 127 - 134. 1. 231. 2011. http://dx.doi.org/10.1016/j.expneurol.2011.05.024 . 10.1016/j.expneurol.2011.05.024 . published Experimental Neurology

Neurotoxicity of heroin-cocaine combinations in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., 2010. Toxicology. 11 - 17. 1. 276. 2010. http://dx.doi.org/10.1016/j.tox.2010.06.009 . 10.1016/j.tox.2010.06.009 . published Toxicology

BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons

Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C., 2009. Neurobiology of Disease. 448 - 456. 3. 35. 2009. http://dx.doi.org/10.1016/j.nbd.2009.06.006 . 10.1016/j.nbd.2009.06.006 . published Neurobiology of Disease

Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF

Almeida, Sandra; Cunha-Oliveira, Teresa; Laço, Mário; Oliveira, Catarina R.; Rego, A. Cristina, 2009. Neurotoxicity Research. 399 - 405. 4. 17. 2009. http://dx.doi.org/10.1007/s12640-009-9116-z . 10.1007/s12640-009-9116-z . published Neurotoxicity Research

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Oliveira, Catarina R., 2008. Brain Research Reviews. 192 - 208. 1. 58. 2008. http://dx.doi.org/10.1016/j.brainresrev.2008.03.002 . 10.1016/j.brainresrev.2008.03.002 . Brain Research Reviews

Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine

Cunha-Oliveira, T; Rego, AC; Macedo, T; Oliveira, CR, 2007. Free Radical Research. S22 - S22. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300068&KeyUID=WOS:000252296300068 . Free Radical Research

Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., 2007. Journal of Neurochemistry. 543 - 554. 2. 101. 2007. http://dx.doi.org/10.1111/j.1471-4159.2006.04406.x . 10.1111/j.1471-4159.2006.04406.x . Journal of Neurochemistry

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://dx.doi.org/10.1016/j.brainres.2006.03.061 . 10.1016/j.brainres.2006.03.061 . published Brain Research

Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells

Domingues, A.; * Oliveira, T.C.; Laço, M.L.N.; Macedo, T.R.A.; Oliveira, C.R.; Rego, A.C., 2006. Annals of the New York Academy of Sciences. 458 - 465. 1074. 2006. http://dx.doi.org/10.1196/annals.1369.046 . 10.1196/annals.1369.046 . published Annals of the New York Academy of Sciences

Efeito crónico da heroína e do peróxido de hidrogénio em células PC12

Cunha-Oliveira, Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina R, 2006. Coimbra Médica V. 21 - 29. 1. 2. 2006. http://hdl.handle.net/10316/18520 . published Coimbra Médica V

Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende, 2006. Toxicology. 54 - 62. 1. 217. 2006. http://dx.doi.org/10.1016/j.tox.2005.08.022 . 10.1016/j.tox.2005.08.022 . Toxicology

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship

Milhazes, N.; Cunha-Oliveira, T.; Martins, P.; Garrido, J.; Oliveira, C.; Rego, A.C.; Borges, F., 2006. Chemical Research in Toxicology. 1294 - 1304. 10. 19. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209029&partnerID=MN8TOARS . 10.1021/tx060123i . Chemical Research in Toxicology

Drugs of abuse induce apoptotic features in PC12 cells

Cunha-Oliveira, T.; Rego, A.C.; Macedo, T.; Oliveira, C.R., 2003. Annals of the New York Academy of Sciences. 667 - 670. 1. 1010. 2003. http://dx.doi.org/10.1196/annals.1299.121 . 10.1196/annals.1299.121 . published Annals of the New York Academy of Sciences

Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells

# Cunha-Oliveira, T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.R.A.; Oliveira, C.R., 2002. Annals of the New York Academy of Sciences. 487 - 496. 965. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036290212&partnerID=MN8TOARS . 10.1111/j.1749-6632.2002.tb04190.x . published Annals of the New York Academy of Sciences

Awards

2019

Best poster, 52nd Annual Meeting of the European Society for Clinical Investigation

2020

Best talk, ESCI Virtual Meeting 2020 - COVID19 edition

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