Biotecnologia

Biomateriais e Terapias Baseadas em Células Estaminais

Envelhecimento

Doenças Cardiovasculares

Células Estaminais

Diferenciação de iPSCs

Nanomateriais

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Líder

Lino Ferreira

Investigador(a)


Linhas de interesse

Programas de modelação de doenças e triagem de medicamentos baseados em modelos de células estaminais

Programas de nanomedicina para modular a atividade das células estaminais e seus progénitos

Visão Geral

O grupo de investigação de biomateriais e terapias baseada em células estaminais foi criado em janeiro de 2008 no CNC. O grupo de investigação tem como objetivo gerar conhecimento fundamental e translacional na intersecção de biomateriais com células estaminais. O grupo de investigação possui duas vias principais de investigação:

  1. Programa de modelação de doenças e rastreamento de medicamentos: modelos de células / tecidos in vitro a partir de células estaminais humanas. As células estaminais, em particular as células estaminais pluripotentes induzidas (iPSCs), podem ser uma excelente fonte de células para modelação de doenças e programas de descoberta de medicamentos relacionados a doenças cardiovasculares. O potencial das iPSCs para gerar modelos de doenças levou à criação de vários biobancos nos EUA (Instituto Coriell de Pesquisa Médica, NIH Center for Regenerative Medicine, ATCC e biobancos de propriedade da Universidade), Europa (Cellartis; e uma iniciativa europeia do biobanco de células estaminais) e Japão (RIKEN bioresource center) para armazenamento e distribuição de linhas iPSC originárias de pacientes e controlos saudáveis. Nos últimos 6 anos, o meu grupo de investigação desenvolveu vários modelos de tecidos a partir de células estaminais que podem ser uma plataforma importante para programas de descoberta de medicamentos relacionados com doenças cardiovasculares. Um interesse particular do grupo é desenvolver plataformas de biomateriais e bioengenharia para a maturação / especificação eficiente de células estaminais e seus progénitos. O grupo de investigação utiliza muitas ferramentas para atingir este objetivo, incluindo o desebnvolvimento de novos biomateriais com informações biológicas relevantes, biologia molecular e celular, sistemas microfluídicos, análise de alto conteúdo e experimentação animal;
  2. Plataformas de nanomedicina para modular a atividade das células estaminais e seus progénitos. O desenvolvimento de um amplo espectro de nanotecnologias (referido como Nanomedicina pelos Institutos Nacionais de Saúde para aplicações na área biomédica) durante os últimos anos é muito promissor para o estudo da biologia de células estaminais e para controlar células estaminais exógenas e endógenas para a medicina regenerativa. O nosso grupo está particularmente interessado em usar essas ferramentas para induzir diferenciação de células estaminais in vivo e mobilizar células estaminais de seus nichos para tratar doenças cardiovasculares. Para esse fim, estamos a desenvolver nanomateriais que liberam biomoléculas com eficiência (pequenas moléculas, proteínas ou RNAs não codificadores) para manipular células estaminais ou seus progénitos.

 

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells

Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel, 2022. Computers in Biology and Medicine. 142. 2022. http://dx.doi.org/10.1016/j.compbiomed.2021.105177 . 10.1016/j.compbiomed.2021.105177 . Computers in Biology and Medicine

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al, 2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al, 2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids

Antimicrobial peptide-based materials: opportunities and challenges

Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al, 2022. Journal of Materials Chemistry B. 2022. https://doi.org/10.1039/D1TB02617H . 10.1039/D1TB02617H . Journal of Materials Chemistry B

Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?

Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro, 2021. Current Oncology. 4874 - 4893. 6. 28. 2021. http://dx.doi.org/10.3390/curroncol28060411 . 10.3390/curroncol28060411 . Current Oncology

Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke

Bernardo-Castro, Sara; Albino, Inês; Barrera-Sandoval, Ángela María; Tomatis, Francesca; Sousa, João André; Martins, Emanuel; Simões, Susana; et al, 2021. Life. 6. 11. 2021. http://dx.doi.org/10.3390/life11060482 . 10.3390/life11060482 . Life

Engineered extracellular vesicles as brain therapeutics

Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino, 2021. Journal of Controlled Release. 472 - 485. 338. 2021. http://dx.doi.org/10.1016/j.jconrel.2021.08.037 . 10.1016/j.jconrel.2021.08.037 . Journal of Controlled Release

Exogenous loading of miRNAs into small extracellular vesicles

Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Tenreiro, Miguel F.; Almeida, Henrique V.; Calmeiro, Tomás; Fortunato, Elvira; Ferreira, Lino; Alves, Paula M.; Serra, Margarida, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-00226-5 . 10.1038/s41598-021-00226-5 . Scientific Reports

Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity

Pires, Cristiana L.; Praça, Catarina; Martins, Patrícia A. T.; Batista de Carvalho, Ana L. M.; Ferreira, Lino; Marques, Maria Paula M.; Moreno, Maria João, 2021. Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101563 . 10.3390/pharmaceutics13101563 . Pharmaceutics

Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides

Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira, 2021. Biomaterials Science. 2021. https://doi.org/10.1039/D1BM01034D . 10.1039/D1BM01034D . Biomaterials Science

High-throughput screening of nanoparticles in drug delivery

Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Almeida, Henrique V.; Tenreiro, Miguel F.; Louro, Ana F.; Abecasis, Bernardo; Santinha, Deolinda; Calmeiro, Tomás; Fortunato, Elvira; et al, 2021. ACS Applied Bio Materials. 1888 - 1899. 2. 4. 2021. http://dx.doi.org/10.1021/acsabm.0c01490 . 10.1021/acsabm.0c01490 . ACS Applied Bio Materials

Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions

Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al, 2021. Nanoscale Horizons. 2021. http://dx.doi.org/10.1039/d0nh00550a . 10.1039/d0nh00550a . published Nanoscale Horizons

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology

Exogenous loading of miRNAs into small extracellular vesicles

Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles

High-throughput screening of nanoparticles in drug delivery

Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering

Biomedical applications of the peptide decorated gold nanoparticles

Rai, Akhilesh; Ferreira, Lino, 2021. Critical Reviews in Biotechnology. 186 - 215. 2. 41. 2021. http://dx.doi.org/10.1080/07388551.2020.1853031 . 10.1080/07388551.2020.1853031 . Critical Reviews in Biotechnology

Revisiting gene delivery to the brain: silencing and editing

João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde, 2021. Biomaterials Science. 1065 - 1087. 4. 9. 2021. https://doi.org/10.1039/D0BM01278E . 10.1039/D0BM01278E . Biomaterials Science

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, 2021. STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma, 2021. Aging. 21991 - 22029. 18. 13. 2021. http://dx.doi.org/10.18632/aging.203556 . 10.18632/aging.203556 . Aging

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)

Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira, 2020. Nanoscale. 2020. https://doi.org/10.1039/C9NR10503D . 10.1039/C9NR10503D . Nanoscale

A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs

Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al, 2020. Angewandte Chemie International Edition. 1985 - 1991. 5. 59. 2020. http://dx.doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie International Edition

Permeability of the blood brain barrier through the phases of ischemic stroke and relation with clinical outcome: protocol for a systematic review

Ferreira, Lino, 2020. BMJ Open. 9. 10. 2020. published BMJ Open

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine

Raquel Ferreira; Joseph Napoli; Tariq Enver; Liliana Bernardino; Lino Ferreira, 2020. Nature Communications. 2020. https://doi.org/10.1038/s41467-020-18042-2 . 10.1038/s41467-020-18042-2 . Nature Communications

Native and bioengineered extracellular vesicles for cardiovascular therapeutics.

de Abreu RC; Fernandes H; da Costa Martins PA; Sahoo S; Emanueli C; Ferreira L, 2020. Nature reviews. Cardiology. 2020. http://europepmc.org/abstract/med/32483304 . 10.1038/s41569-020-0389-5 . Nature reviews. Cardiology

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; et al, 2020. Nature communications. 2020. http://europepmc.org/abstract/med/32807790 . 10.1038/s41467-020-17901-2 . Nature communications

Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.

Buczak K; Kirkpatrick JM; Truckenmueller F; Santinha D; Ferreira L; Roessler S; Singer S; Beck M; Ori A, 2020. Nature protocols. 2020. http://europepmc.org/abstract/med/32737464 . 10.1038/s41596-020-0356-y . Nature protocols

Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

Bernardo-Castro, Sara; Sousa, João André; Brás, Ana; Cecília, Carla; Rodrigues, Bruno; Almendra, Luciano; Machado, Cristina; et al, 2020. Frontiers in Neurology. 11. 2020. http://dx.doi.org/10.3389/fneur.2020.594672 . 10.3389/fneur.2020.594672 . Frontiers in Neurology

In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02718-1 . 10.1007/s00204-020-02718-1 . Archives of Toxicology

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, 2020. Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino, 2020. Nature Reviews Cardiology. 685 - 697. 11. 17. 2020. http://dx.doi.org/10.1038/s41569-020-0389-5 . 10.1038/s41569-020-0389-5 . Nature Reviews Cardiology

Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02735-0 . 10.1007/s00204-020-02735-0 . Archives of Toxicology

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.

Ferreira, Lino, 2019. Stem cell reports. 2019. https://europepmc.org/articles/PMC6829749 . 10.1016/j.stemcr.2019.08.002 . Stem cell reports

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira, 2019. Nanoscale. 13243 - 13248. 28. 11. 2019. https://doi.org/10.1039/C9NR02512J . 10.1039/C9NR02512J . Nanoscale

Bioprocess decision support tool for scalable manufacture of extracellular vesicles

Ferreira, Lino, 2019. Biotechnology and Bioengineering. 2019. http://dx.doi.org/10.1002/bit.26809 . 10.1002/bit.26809 . Biotechnology and Bioengineering

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity

Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Ferreira, Lino, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-40417-9 . 10.1038/s41598-019-40417-9 . Scientific Reports

A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

Tian-tian Yao; Jing Wang; Yun-fan Xue; Wei-jiang Yu; Qiang Gao; Lino Ferreira; Ke-Feng Ren; Jian Ji, 2019. Journal of Materials Chemistry B. 2019. https://doi.org/10.1039/C9TB01069F . 10.1039/C9TB01069F . Journal of Materials Chemistry B

Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model

Bernardo Abecasis; Patrícia Gomes-Alves; Susana Rosa; Pedro J. Gouveia; Lino Ferreira; Margarida Serra; Paula M. Alves, 2019. Biotechnology and Bioengineering. 1245 - 1252. 5. 116. 2019. https://doi.org/10.1002/bit.26929 . 10.1002/bit.26929 . Biotechnology and Bioengineering

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Ferreira, Lino, 2019. ACS Nano. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Ferreira, Lino, 2019. Journal of Nanobiotechnology. 2019. http://dx.doi.org/10.1186/s12951-019-0530-y . 10.1186/s12951-019-0530-y . Journal of Nanobiotechnology

A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.

Ferreira, Lino, 2019. Angewandte Chemie (International ed. in English). 2019. https://doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie (International ed. in English)

What human blood-brain barrier models can tell us about BBB function and drug discovery?

Ferreira, Lino, 2019. Expert opinion on drug discovery. 2019. https://doi.org/10.1080/17460441.2019.1646722 . 10.1080/17460441.2019.1646722 . Expert opinion on drug discovery

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

Neves, Ricardo, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-45352-3 . 10.1038/s41598-019-45352-3 . Scientific Reports

Spatially Confining Surface Roughness on Exponentially Growing Polyelectrolyte Multilayer Films

Ferreira, Lino, 2019. Advanced Materials Interfaces. 2019. http://dx.doi.org/10.1002/admi.201900702 . 10.1002/admi.201900702 . Advanced Materials Interfaces

The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics

Othman, Ziryan; Fernandes, Hugo; Groot, Arjan J.; Luider, Theo M.; Alcinesio, Alessandro; Pereira, Daniel de Melo; Guttenplan, Alexander P.M.; Yuan, Huipin; Habibovic, Pamela, 2019. Biomaterials. 12 - 24. 210. 2019. http://dx.doi.org/10.1016/j.biomaterials.2019.04.021 . 10.1016/j.biomaterials.2019.04.021 . Biomaterials

From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation

Honglin Chen; Danielle F. Baptista; Giuseppe Criscenti; João Crispim; Hugo Fernandes; Clemens van Blitterswijk; Roman Truckenmüller; Lorenzo Moroni, 2019. Nanoscale. 14312 - 14321. 30. 11. 2019. https://doi.org/10.1039/C8NR10108F . 10.1039/C8NR10108F . Nanoscale

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity

Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 1. 50. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology

Soft-molecular imprinted electrospun scaffolds to mimic specific biological tissues.

Criscenti G; De Maria C; Longoni A; van Blitterswijk CA; Fernandes HAM; Vozzi G; Moroni L, 2018. Biofabrication. 2018. http://europepmc.org/abstract/med/30024388 . 10.1088/1758-5090/aad48a . Biofabrication

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J., 2018. Nature Communications. 1. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS . 10.1038/s41467-017-02787-4 . Nature Communications

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

Ferreira, Lino, 2018. Cell Reports. 2018. http://dx.doi.org/10.1016/j.celrep.2018.11.032 . 10.1016/j.celrep.2018.11.032 . Cell Reports

Light-triggerable formulations for the intracellular controlled release of biomolecules.

Lino MM; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29326080 . 10.1016/j.drudis.2018.01.019 . Drug discovery today

Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation

Neves, Ricardo, 2018. Frontiers in Cell and Developmental Biology. 2018. http://dx.doi.org/10.3389/fcell.2018.00103 . 10.3389/fcell.2018.00103 . Frontiers in Cell and Developmental Biology

Stem cells as vehicles and targets of nanoparticles.

Pinho S; Macedo MH; Rebelo C; Sarmento B; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29337203 . 10.1016/j.drudis.2018.01.030 . Drug discovery today

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Neves, Ricardo, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain

Ferreira, Lino, 2018. Neuroscience Letters. 2018. http://dx.doi.org/10.1016/j.neulet.2018.02.066 . 10.1016/j.neulet.2018.02.066 . Neuroscience Letters

Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics

André F. Ferreira; Michela Comune; Akhilesh Rai; Lino Ferreira; Pedro N. Simões, 2018. The Journal of Physical Chemistry B. 2018. https://doi.org/10.1021/acs.jpcb.8b05717 . 10.1021/acs.jpcb.8b05717 . The Journal of Physical Chemistry B

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Ferreira, Lino, 2018. Frontiers in Neurology. 2018. http://dx.doi.org/10.3389/fneur.2018.00302 . 10.3389/fneur.2018.00302 . Frontiers in Neurology

Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis

Ghebes, Corina Adriana; Groen, Nathalie; Cheuk, Yau Chuk; Fu, Sai Chuen; Fernandes, Hugo Machado; Saris, Daniel B.F., 2018. Tissue Engineering Part A. 322 - 334. 3-4. 24. 2018. http://dx.doi.org/10.1089/ten.tea.2016.0546 . 10.1089/ten.tea.2016.0546 . Tissue Engineering Part A

Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation

Ferreira, Lino, 2018. Advanced Materials Interfaces. 2018. http://dx.doi.org/10.1002/admi.201801390 . 10.1002/admi.201801390 . Advanced Materials Interfaces

MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo

Ferreira, Lino, 2018. PLOS ONE. 2018. http://dx.doi.org/10.1371/journal.pone.0193609 . 10.1371/journal.pone.0193609 . PLOS ONE

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Ferreira, Lino, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.

Sargento-Freitas J; Aday S; Nunes C; Cordeiro M; Gouveia A; Silva F; Machado C; et al, 2018. Neurology. 2018. http://europepmc.org/abstract/med/29237797 . 10.1212/wnl.0000000000004801 . Neurology

Substrate Topography Modulates Cell Aging on a Progeria Cell Model

Patricia R. Pitrez; Luís Estronca; Helena Vazão; Anne-Laure Egesipe; Amélie Le Corf; Claire Navarro; Nicolas Lévy; et al, 2018. ACS Biomaterials Science & Engineering. 2018. https://doi.org/10.1021/acsbiomaterials.8b00224 . 10.1021/acsbiomaterials.8b00224 . ACS Biomaterials Science & Engineering

Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.7b00820 . 10.1021/acs.bioconjchem.7b00820 . Bioconjugate Chemistry

Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction.

Crispim JF; Fu SC; Lee YW; Fernandes HAM; Jonkheijm P; Yung PSH; Saris DBF, 2018. The American journal of sports medicine. 2018. http://europepmc.org/abstract/med/30074814 . 10.1177/0363546518787507 . The American journal of sports medicine

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira, 2018. ACS Nano. 2018. https://doi.org/10.1021/acsnano.7b07538 . 10.1021/acsnano.7b07538 . ACS Nano

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Ferreira, Lino, 2018. Journal of the Neurological Sciences. 2018. http://dx.doi.org/10.1016/j.jns.2017.12.028 . 10.1016/j.jns.2017.12.028 . Journal of the Neurological Sciences

A nanoformulation for the preferential accumulation in adult neurogenic niches

Ferreira, Lino, 2018. Journal of Controlled Release. 2018. http://dx.doi.org/10.1016/j.jconrel.2018.06.013 . 10.1016/j.jconrel.2018.06.013 . Journal of Controlled Release

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.

Gouveia PJ; Rosa S; Ricotti L; Abecasis B; Almeida HV; Monteiro L; Nunes J; et al, 2017. Biomaterials. 2017. http://europepmc.org/abstract/med/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Restoring heart function and electrical integrity: closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29302345 . 10.1038/s41536-017-0015-2 . NPJ Regenerative medicine

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.

Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al, 2017. Small (Weinheim an der Bergstrasse, Germany). 2017. http://europepmc.org/abstract/med/28211642 . 10.1002/smll.201603737 . Small (Weinheim an der Bergstrasse, Germany)

High-throughput identification of small molecules that affect human embryonic vascular development.

Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America

High throughput screening of photocatalytic conversion of pharmaceutical contaminants in water

Romão, Joana; Barata, David; Ribeiro, Nelson; Habibovic, Pamela; Fernandes, Hugo; Mul, Guido, 2017. Environmental Pollution. 1199 - 1207. 220. 2017. http://dx.doi.org/10.1016/j.envpol.2016.11.015 . 10.1016/j.envpol.2016.11.015 . Environmental Pollution

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.

Aday S; Zoldan J; Besnier M; Carreto L; Saif J; Fernandes R; Santos T; et al, 2017. Nature communications. 2017. http://europepmc.org/abstract/med/28963481 . 10.1038/s41467-017-00746-7 . Nature communications

Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.

Santos T; Ferreira R; Quartin E; Boto C; Saraiva C; Bragança J; Peça J; et al, 2017. Acta biomaterialia. 2017. http://europepmc.org/abstract/med/28673742 . 10.1016/j.actbio.2017.06.044 . Acta biomaterialia

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential.

Comune M; Rai A; Chereddy KK; Pinto S; Aday S; Ferreira AF; Zonari A; et al, 2017. Journal of controlled release : official journal of the Controlled Release Society. 2017. http://europepmc.org/abstract/med/28694030 . 10.1016/j.jconrel.2017.07.007 . Journal of controlled release : official journal of the Controlled Release Society

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.

Ribeiro-Rodrigues TM; Laundos TL; Pereira-Carvalho R; Batista-Almeida D; Pereira R; Coelho-Santos V; Silva AP; et al, 2017. Cardiovascular research. 2017. http://europepmc.org/abstract/med/28859292 . 10.1093/cvr/cvx118 . Cardiovascular research

Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro

Ekwueme, Emmanuel C.; Mohiuddin, Mahir; Yarborough, Jazmin A.; Brolinson, P. Gunnar; Docheva, Denitsa; Fernandes, Hugo A. M.; Freeman, Joseph W., 2017. Clinical Orthopaedics and Related Research®. 2117 - 2127. 8. 475. 2017. http://dx.doi.org/10.1007/s11999-017-5370-1 . 10.1007/s11999-017-5370-1 . Clinical Orthopaedics and Related Research®

Challenging the great vascular wall: Can we envision a simple yet comprehensive therapy for stroke?

Machado-Pereira M; Santos T; Ferreira L; Bernardino L; Ferreira R, 2017. Journal of tissue engineering and regenerative medicine. 2017. http://europepmc.org/abstract/med/28182332 . 10.1002/term.2427 . Journal of tissue engineering and regenerative medicine

Erratum: Restoring heart function and electrical integrity: Closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29303158 . 10.1038/s41536-017-0020-5 . NPJ Regenerative medicine

TGF-ß1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces

Crispim, J.; Fernandes, H.A.M.; Fu, S.C.; Lee, Y.W.; Jonkheijm, P.; Saris, D.B.F., 2017. Acta Biomaterialia. 165 - 178. 53. 2017. http://dx.doi.org/10.1016/j.actbio.2017.01.066 . 10.1016/j.actbio.2017.01.066 . Acta Biomaterialia

High-throughput identification of small molecules that affect human embryonic vascular development.

Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 .

Intracellular delivery of more than one protein with spatio-temporal control

Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira; Lino MM; Simões S; Pinho S; Ferreira L, 2017. Nanoscale. 18668 - 18680. 47. 9. 2017. https://doi.org/10.1039/C7NR02414B . 10.1039/C7NR02414B . Nanoscale

Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles

Ferreira, Lino, 2017. Mediators of Inflammation. 2017. http://dx.doi.org/10.1155/2017/6742427 . 10.1155/2017/6742427 . Mediators of Inflammation

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

Gouveia, P.J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H.V.; Monteiro, L.; Nunes, J.; et al, 2017. Biomaterials. 213 - 228. 139. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020728965&partnerID=MN8TOARS . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies

Ferreira, Lino, 2017. European Biophysics Journal. 2017. http://dx.doi.org/10.1007/s00249-016-1160-z . 10.1007/s00249-016-1160-z . European Biophysics Journal

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, C.; Quartin, E.; Cai, Y.; Martín-Lorenzo, A.; Cenador, M.B.G.; Pinto, S.; Gupta, R.; et al, 2017. Nature Communications. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026559803&partnerID=MN8TOARS . 10.1038/ncomms15204 . Nature Communications

Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.

Aday S; Cecchelli R; Hallier-Vanuxeem D; Dehouck MP; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26838094 . 10.1016/j.tibtech.2016.01.001 . Trends in biotechnology

Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.

Santos T; Boto C; Saraiva CM; Bernardino L; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26917252 . 10.1016/j.tibtech.2016.02.003 . Trends in biotechnology

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.

Saraiva C; Paiva J; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27269730 . 10.1016/j.jconrel.2016.06.005 . Journal of controlled release : official journal of the Controlled Release Society

Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.

Saraiva C; Praça C; Ferreira R; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27208862 . 10.1016/j.jconrel.2016.05.044 . Journal of controlled release : official journal of the Controlled Release Society

Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation.

Ghebes CA; Braham MV; Zeegers AV; Renard AJ; Fernandes H; Saris DB, 2016. 2016. http://europepmc.org/abstract/med/27955656 .

High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide.

Maleki H; Rai A; Pinto S; Evangelista M; Cardoso RM; Paulo C; Carvalheiro T; et al, 2016. ACS applied materials & interfaces. 2016. http://europepmc.org/abstract/med/27074633 . 10.1021/acsami.6b03355 . ACS applied materials & interfaces

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model.

Rai A; Pinto S; Velho TR; Ferreira AF; Moita C; Trivedi U; Evangelista M; et al, 2016. Biomaterials. 2016. http://europepmc.org/abstract/med/26866877 . 10.1016/j.biomaterials.2016.01.051 . Biomaterials

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-ß1 Signaling Pathway

Ghebes, Corina-Adriana; van Lente, Jéré; Post, Janine Nicole; Saris, Daniel B. F.; Fernandes, Hugo, 2016. SLAS DISCOVERY: Advancing Life Sciences R&D. 40 - 50. 1. 22. 2016. http://dx.doi.org/10.1177/1087057116669346 . 10.1177/1087057116669346 . SLAS DISCOVERY: Advancing Life Sciences R&D

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells.

Rai A; Pinto S; Evangelista MB; Gil H; Kallip S; Ferreira MG; Ferreira L, 2016. Acta biomaterialia. 2016. http://europepmc.org/abstract/med/26821340 . 10.1016/j.actbio.2016.01.035 . Acta biomaterialia

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.

Blondel S; Egesipe AL; Picardi P; Jaskowiak AL; Notarnicola M; Ragot J; Tournois J; et al, 2016. Cell death & disease. 2016. http://europepmc.org/abstract/med/26890144 . 10.1038/cddis.2015.374 . Cell death & disease

Traceable microRNA-124 loaded nanoparticles as a new promising therapeutic tool for Parkinson's disease.

Saraiva C; Ferreira L; Bernardino L, 2016. Neurogenesis (Austin, Tex.). 2016. http://europepmc.org/abstract/med/28405588 . 10.1080/23262133.2016.1256855 . Neurogenesis (Austin, Tex.)

Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

Ferreira, Lino, 2016. Applied In Vitro Toxicology. 2016. http://dx.doi.org/10.1089/aivt.2016.0002 . 10.1089/aivt.2016.0002 . Applied In Vitro Toxicology

Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia.

Ferreira R; Fonseca MC; Santos T; Sargento-Freitas J; Tjeng R; Paiva F; Castelo-Branco M; Ferreira LS; Bernardino L, 2016. Nanoscale. 2016. http://europepmc.org/abstract/med/27025400 . 10.1039/c5nr09077f . Nanoscale

Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease.

Esteves M; Cristóvão AC; Saraiva T; Rocha SM; Baltazar G; Ferreira L; Bernardino L, 2015. 2015. http://europepmc.org/abstract/med/25798108 . 10.3389/fnagi.2015.00020 .

Vascular disease modeling using induced pluripotent stem cells: focus in Hutching-Gilford progeria syndrome.

Pitrez P; Rosa SC; Almeida C; Ferreira L, 2015. 2015. http://europepmc.org/abstract/med/26474704 .

High throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 cells.

Le B; Fernandes H; Bouten C; Karperien M; van Blitterswijk C; de Boer J, 2015. 2015. http://europepmc.org/abstract/med/25604243 . 10.1089/ten.TEC.2014.0088 .

Anterior cruciate ligament- and hamstring tendon-derived cells: in vitro differential properties of cells involved in ACL reconstruction

Ghebes, Corina Adriana; Kelder, Cindy; Schot, Thomas; Renard, Auke J.; Pakvis, Dean F. M.; Fernandes, Hugo; Saris, Daniel B., 2015. Journal of Tissue Engineering and Regenerative Medicine. 1077 - 1088. 4. 11. 2015. http://dx.doi.org/10.1002/term.2009 . 10.1002/term.2009 . Journal of Tissue Engineering and Regenerative Medicine

An overview of new translational, clinical and therapeutic perspectives in laminopathies and other nuclear envelope-related diseases.  Proceedings of the 1st French-Italian meeting on laminopathies & other nuclear envelope-related diseases

Ferreira, Lino, 2015. Orphanet Journal of Rare Diseases . 2015. 10.1186/1750-1172-10-S2-I1 . Orphanet Journal of Rare Diseases

Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro

Ekwueme, Emmanuel C.; Shah, Jay V.; Mohiuddin, Mahir; Ghebes, Corina A.; Crispim, João F.; Saris, Daniël B.F.; Fernandes, Hugo A.M.; Freeman, Joseph W., 2015. Journal of Cellular Biochemistry. 684 - 693. 3. 117. 2015. http://dx.doi.org/10.1002/jcb.25353 . 10.1002/jcb.25353 . Journal of Cellular Biochemistry

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

Higuera, Gustavo A.; Fernandes, Hugo; Spitters, Tim W.G.M.; van de Peppel, Jeroen; Aufferman, Nils; Truckenmueller, Roman; Escalante, Maryana; et al, 2015. Biomaterials. 190 - 202. 61. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.05.017 . 10.1016/j.biomaterials.2015.05.017 . Biomaterials

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

Guantes, R.; Rastrojo, A.; Neves, R.; Lima, A.; Aguado, B.; Iborra, F.J., 2015. Genome Research. 633 - 644. 5. 125. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929660832&partnerID=MN8TOARS . 10.1101/gr.178426.114 . Genome Research

Development of a SMCs model from HGPS-iPS and proofs of principle.

Ferreira L, 2015. Orphanet journal of rare diseases. 2015. http://europepmc.org/abstract/PMC/PMC4652490 . 10.1186/1750-1172-10-s2-o3 . Orphanet journal of rare diseases

Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions.

Kostic I; Fidalgo-Carvalho I; Aday S; Vazão H; Carvalheiro T; Grãos M; Duarte A; et al, 2015. Scientific reports. 2015. http://europepmc.org/abstract/med/26553339 . 10.1038/srep16406 . Scientific reports

Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation

Pereira, M.J.N.; Sundback, C.A.; Lang, N.; Cho, W.K.; Pomerantseva, I.; Ouyang, B.; Tao, S.L.; et al, 2014. Advanced Healthcare Materials. 565 - 571. 4. 3. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898634094&partnerID=MN8TOARS . 10.1002/adhm.201300264 . Advanced Healthcare Materials

A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects

Lang, N.; Pereira, M.J.; Lee, Y.; Friehs, I.; Vasilyev, N.V.; Feins, E.N.; Ablasser, K.; et al, 2014. Science Translational Medicine. 218. 6. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892553926&partnerID=MN8TOARS . 10.1126/scitranslmed.3006557 . Science Translational Medicine

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

Cecchelli, R.; Aday, S.; Sevin, E.; Almeida, C.; Culot, M.; Dehouck, L.; Coisne, C.; et al, 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903316132&partnerID=MN8TOARS . 10.1371/journal.pone.0099733 . PLoS ONE

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

Chereddy KK; Her CH; Comune M; Moia C; Lopes A; Porporato PE; Vanacker J; et al, 2014. 2014. http://europepmc.org/abstract/med/25173841 . 10.1016/j.jconrel.2014.08.016 .

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

Ferreira, Lino, 2014. RSC Adv.. 2014. http://dx.doi.org/10.1039/c4ra04041d . 10.1039/c4ra04041d . RSC Adv.

Interaction of fullerene nanoparticles with biomembranes: From the partition in lipid membranes to effects on mitochondrial bioenergetics

Santos, S.M.; Dinis, A.M.; Peixoto, F.; Ferreira, L.; Jurado, A.S.; Videira, R.A., 2014. Toxicological Sciences. 117 - 129. 1. 138. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894311599&partnerID=MN8TOARS . 10.1093/toxsci/kft327 . Toxicological Sciences

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

A highly tunable biocompatible and multifunctional biodegradable elastomer

Pereira, M.J.N.; Ouyang, B.; Sundback, C.A.; Lang, N.; Friehs, I.; Mureli, S.; Pomerantseva, I.; et al, 2013. Advanced Materials. 1209 - 1215. 8. 25. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874103151&partnerID=MN8TOARS . 10.1002/adma.201203824 . Advanced Materials

Differential internalization of amphotericin B - Conjugated nanoparticles in human cells and the expression of heat shock protein 70

Paulo, C.S.O.; Lino, M.M.; Matos, A.A.; Ferreira, L.S., 2013. Biomaterials. 5281 - 5293. 21. 34. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877046831&partnerID=MN8TOARS . 10.1016/j.biomaterials.2013.03.048 . Biomaterials

Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles

Lino, M.M.; Paulo, C.S.O.; Vale, A.C.; Vaz, M.F.; Ferreira, L.S., 2013. Dental Materials. 10. 29. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884143064&partnerID=MN8TOARS . 10.1016/j.dental.2013.07.023 . Dental Materials

A small molecule approach to engineering vascularized tissue

Doorn, Joyce; Fernandes, Hugo A. M.; Le, Bach Q.; van de Peppel, Jeroen; van Leeuwen, Johannes P. T. M.; De Vries, Margreet R.; Aref, Zeen; et al, 2013. Biomaterials. 3053 - 3063. 12. 34. 2013. 10.1016/j.biomaterials.2012.12.037 . Biomaterials

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes

Thakkar, Shraddha; Ghebes, Corina A.; Ahmed, Maqsood; Kelder, Cindy; van Blitterswijk, Clemens A.; Saris, Daniel; Fernandes, Hugo A. M.; Moroni, Lorenzo, 2013. Biofabrication. 2. 5. 2013. 10.1088/1758-5082/5/2/025003 . Biofabrication

Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells

Barradas, Ana M. C.; Monticone, Veronica; Hulsman, Marc; Danoux, Charlene; Fernandes, Hugo; Birgani, Zeinab Tahmasebi; Barrere-de Groot, Florence; et al, 2013. Integrative Biology. 920 - 931. 7. 5. 2013. 10.1039/c3ib40027a . Integrative Biology

Boron Nitride Nanotube-Mediated Stimulation of Cell Co-Culture on Micro-Engineered Hydrogels

Ricotti, L.; Fujie, T.; Vazão, H.; Ciofani, G.; Marotta, R.; Brescia, R.; Filippeschi, C.; et al, 2013. PLoS ONE. 8. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881503335&partnerID=MN8TOARS . 10.1371/journal.pone.0071707 . PLoS ONE

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells

Barradas, Ana M.C.; Fernandes, Hugo A.M.; Groen, Nathalie; Chai, Yoke Chin; Schrooten, Jan; van de Peppel, Jeroen; van Leeuwen, Johannes P.T.M.; van Blitterswijk, Clemens A.; de Boer, Jan, 2012. Biomaterials. 3205 - 3215. 11. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.01.020 . 10.1016/j.biomaterials.2012.01.020 . Biomaterials

Nanomedicine boosts neurogenesis: New strategies for brain repair

Santos, T.; Maia, J.; Agasse, F.; Xapelli, S.; Ferreira, L.; Bernardino, L., 2012. Integrative Biology (United Kingdom). 973 - 981. 9. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870939373&partnerID=MN8TOARS . 10.1039/c2ib20129a . Integrative Biology (United Kingdom)

Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and ß-tricalcium phosphate.

Prins HJ; Fernandes H; Rozemuller H; van Blitterswijk C; de Boer J; Martens AC, 2012. 2012. http://europepmc.org/abstract/med/23255230 . 10.1002/term.1681 .

Mitochondrial variability as a source of extrinsic cellular noise

Johnston, I.G.; Gaal, B.; das Neves, R.P.; Enver, T.; Iborra, F.J.; Jones, N.S., 2012. PLoS Computational Biology. 3. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861161954&partnerID=MN8TOARS . 10.1371/journal.pcbi.1002416 . PLoS Computational Biology

Endothelial Differentiation of Mesenchymal Stromal Cells

Portalska, Karolina Janeczek; Leferink, Anne; Groen, Nathalie; Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan, 2012. Plos One. 10. 7. 2012. 10.1371/journal.pone.0046842 . Plos One

The influence of genetic factors on the osteoinductive potential of calcium phosphate ceramics in mice

Barradas, Ana M.C.; Yuan, Huipin; van der Stok, Johan; Le Quang, Bach; Fernandes, Hugo; Chaterjea, Anindita; Hogenes, Marieke C.H.; et al, 2012. Biomaterials. 5696 - 5705. 23. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.04.021 . 10.1016/j.biomaterials.2012.04.021 . Biomaterials

Epigenetic engineering to reverse the Parkinson's expression state

Valente, A.X.C.N.; das Neves, R.P.; Oliveira, P.J., 2012. Parkinsonism and Related Disorders. 717 - 721. 6. 18. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS . 10.1016/j.parkreldis.2012.04.018 . Parkinsonism and Related Disorders

Histamine modulates microglia function.

Ferreira R; Santos T; Gonçalves J; Baltazar G; Ferreira L; Agasse F; Bernardino L, 2012. 2012. http://europepmc.org/abstract/med/22569158 . 10.1186/1742-2094-9-90 .

Histamine stimulates neurogenesis in the rodent subventricular zone

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Fabrication of Bioactive Composite Scaffolds by Electrospinning for Bone Regeneration

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In Vitro and In Vivo Bioluminescent Imaging of Hypoxia in Tissue-Engineered Grafts

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Endogenous Collagen Influences Differentiation of Human Multipotent Mesenchymal Stromal Cells

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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

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Non-leaching surfaces capable of killing microorganisms on contact

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Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells

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cAMP/PKA Signaling Inhibits Osteogenic Differentiation and Bone Formation in Rodent Models

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Extracellular matrix and tissue engineering applications

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The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells

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New Opportunities: The Use of Nanotechnologies to Manipulate and Track Stem Cells

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A biodegradable and biocompatible gecko-inspired tissue adhesive

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The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.

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Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates

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Structural analysis of dextran-based hydrogels obtained chemoenzymatically

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Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice

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Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: Surface characterization and pull-out tests

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Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels

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Synthesis and characterization of new injectable and degradable dextran-based hydrogels

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Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels

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Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice

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Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

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Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (Subtilisin Carlsberg)

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Cr(V) involvement in the toxicity pathway of testicular damage

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Exquisite regioselectivity and increased transesterification activity of an immobilized Bacillus subtilis protease

Ferreira, L.; Ramos, M.A.; Gil, M.H.; Dordick, J.S., 2002. Biotechnology Progress. 986 - 993. 5. 18. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036753108&partnerID=MN8TOARS . 10.1021/bp0255457 . Biotechnology Progress

Biocatalytic polytransesterification of inulin with divinyladipate

Ferreira, L.; Gil, M.H.; Carvalho, R.; Geraldes, C.F.G.C.; Kim, D.-Y.; Dordick, J.S., 2002. Chemistry of Materials. 4009 - 4011. 10. 14. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036799646&partnerID=MN8TOARS . 10.1021/cm020393w . Chemistry of Materials

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature

Carvalho, M.; Carvalho, F.; Remião, F.; De Lourdes Pereira, M.; Pires-Das-Neves, R.; De Lourdes Bastos, M., 2002. Archives of Toxicology. 166 - 172. 3. 76. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036214775&partnerID=MN8TOARS . 10.1007/s00204-002-0324-z . Archives of Toxicology

Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds

Pires Das Neves, R.; Santos, T.M.; De Lourdes Pereira, M.; Pedrosa De Jesus, J., 2002. Human and Experimental Toxicology. 365 - 369. 7. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036656032&partnerID=MN8TOARS . 10.1191/0960327102ht243oa . Human and Experimental Toxicology

Enzymatic synthesis of dextran-containing hydrogels

Ferreira, L.; Gil, M.H.; Dordick, J.S.; Carvalho, R., 2002. Biomaterials. 3957 - 3967. 19. 23. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036020043&partnerID=MN8TOARS . 10.1016/S0142-9612(02)00132-1 . Biomaterials

Chromium(VI) induced alterations in mouse spleen cells: A short-term assay

Das Neves, R.P.; Santos, T.M.; Pereira, M.D.L.; De Jesus, J.P., 2001. Cytobios. 27 - 34. 1 SUPPL.. 413. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348238820&partnerID=MN8TOARS . Cytobios

Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties

Ferreira, Lino, 2001. Chemical educator. 2001. http://link.springer.com/article/10.1007%2Fs00897010461a . 10.1007/s00897010461a . Chemical educator

Preparation and characterization of gels based on sucrose modified with glycidyl methacrylate

Ferreira, L.; Vidal, M.M.; Geraldes, C.F.G.C.; Gil, M.H., 2000. Carbohydrate Polymers. 15 - 24. 1. 41. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033908440&partnerID=MN8TOARS . 10.1016/S0144-8617(99)00064-8 . Carbohydrate Polymers

Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values

Ferreira, L.; Vidal, M.M.; Gil, M.H., 2000. International Journal of Pharmaceutics. 169 - 180. 2. 194. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968976&partnerID=MN8TOARS . 10.1016/S0378-5173(99)00375-0 . International Journal of Pharmaceutics

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