Envelhecimento
Doenças Cardiovasculares
Células Estaminais
Diferenciação de iPSCs
Nanomateriais
Programas de modelação de doenças e triagem de medicamentos baseados em modelos de células estaminais
Programas de nanomedicina para modular a atividade das células estaminais e seus progénitos
O grupo de investigação de biomateriais e terapias baseada em células estaminais foi criado em janeiro de 2008 no CNC. O grupo de investigação tem como objetivo gerar conhecimento fundamental e translacional na intersecção de biomateriais com células estaminais. O grupo de investigação possui duas vias principais de investigação:
Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.
Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells
Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel, 2022. Computers in Biology and Medicine. 142. 2022. http://dx.doi.org/10.1016/j.compbiomed.2021.105177 . 10.1016/j.compbiomed.2021.105177 . Computers in Biology and Medicine
Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells
Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al, 2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al, 2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids
Antimicrobial peptide-based materials: opportunities and challenges
Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al, 2022. Journal of Materials Chemistry B. 2022. https://doi.org/10.1039/D1TB02617H . 10.1039/D1TB02617H . Journal of Materials Chemistry B
Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?
Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro, 2021. Current Oncology. 4874 - 4893. 6. 28. 2021. http://dx.doi.org/10.3390/curroncol28060411 . 10.3390/curroncol28060411 . Current Oncology
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke
Bernardo-Castro, Sara; Albino, Inês; Barrera-Sandoval, Ángela María; Tomatis, Francesca; Sousa, João André; Martins, Emanuel; Simões, Susana; et al, 2021. Life. 6. 11. 2021. http://dx.doi.org/10.3390/life11060482 . 10.3390/life11060482 . Life
Engineered extracellular vesicles as brain therapeutics
Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino, 2021. Journal of Controlled Release. 472 - 485. 338. 2021. http://dx.doi.org/10.1016/j.jconrel.2021.08.037 . 10.1016/j.jconrel.2021.08.037 . Journal of Controlled Release
Exogenous loading of miRNAs into small extracellular vesicles
Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles
Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization
Tenreiro, Miguel F.; Almeida, Henrique V.; Calmeiro, Tomás; Fortunato, Elvira; Ferreira, Lino; Alves, Paula M.; Serra, Margarida, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-00226-5 . 10.1038/s41598-021-00226-5 . Scientific Reports
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity
Pires, Cristiana L.; Praça, Catarina; Martins, Patrícia A. T.; Batista de Carvalho, Ana L. M.; Ferreira, Lino; Marques, Maria Paula M.; Moreno, Maria João, 2021. Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101563 . 10.3390/pharmaceutics13101563 . Pharmaceutics
Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides
Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira, 2021. Biomaterials Science. 2021. https://doi.org/10.1039/D1BM01034D . 10.1039/D1BM01034D . Biomaterials Science
High-throughput screening of nanoparticles in drug delivery
Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering
Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation
Almeida, Henrique V.; Tenreiro, Miguel F.; Louro, Ana F.; Abecasis, Bernardo; Santinha, Deolinda; Calmeiro, Tomás; Fortunato, Elvira; et al, 2021. ACS Applied Bio Materials. 1888 - 1899. 2. 4. 2021. http://dx.doi.org/10.1021/acsabm.0c01490 . 10.1021/acsabm.0c01490 . ACS Applied Bio Materials
Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions
Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al, 2021. Nanoscale Horizons. 2021. http://dx.doi.org/10.1039/d0nh00550a . 10.1039/d0nh00550a . published Nanoscale Horizons
Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research
Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology
Exogenous loading of miRNAs into small extracellular vesicles
Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles
High-throughput screening of nanoparticles in drug delivery
Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering
Biomedical applications of the peptide decorated gold nanoparticles
Rai, Akhilesh; Ferreira, Lino, 2021. Critical Reviews in Biotechnology. 186 - 215. 2. 41. 2021. http://dx.doi.org/10.1080/07388551.2020.1853031 . 10.1080/07388551.2020.1853031 . Critical Reviews in Biotechnology
Revisiting gene delivery to the brain: silencing and editing
João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde, 2021. Biomaterials Science. 1065 - 1087. 4. 9. 2021. https://doi.org/10.1039/D0BM01278E . 10.1039/D0BM01278E . Biomaterials Science
Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use
Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, 2021. STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine
Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression
Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma, 2021. Aging. 21991 - 22029. 18. 13. 2021. http://dx.doi.org/10.18632/aging.203556 . 10.18632/aging.203556 . Aging
A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies
Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods
A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)
Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira, 2020. Nanoscale. 2020. https://doi.org/10.1039/C9NR10503D . 10.1039/C9NR10503D . Nanoscale
A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs
Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al, 2020. Angewandte Chemie International Edition. 1985 - 1991. 5. 59. 2020. http://dx.doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie International Edition
Permeability of the blood brain barrier through the phases of ischemic stroke and relation with clinical outcome: protocol for a systematic review
Ferreira, Lino, 2020. BMJ Open. 9. 10. 2020. published BMJ Open
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Raquel Ferreira; Joseph Napoli; Tariq Enver; Liliana Bernardino; Lino Ferreira, 2020. Nature Communications. 2020. https://doi.org/10.1038/s41467-020-18042-2 . 10.1038/s41467-020-18042-2 . Nature Communications
Native and bioengineered extracellular vesicles for cardiovascular therapeutics.
de Abreu RC; Fernandes H; da Costa Martins PA; Sahoo S; Emanueli C; Ferreira L, 2020. Nature reviews. Cardiology. 2020. http://europepmc.org/abstract/med/32483304 . 10.1038/s41569-020-0389-5 . Nature reviews. Cardiology
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; et al, 2020. Nature communications. 2020. http://europepmc.org/abstract/med/32807790 . 10.1038/s41467-020-17901-2 . Nature communications
Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
Buczak K; Kirkpatrick JM; Truckenmueller F; Santinha D; Ferreira L; Roessler S; Singer S; Beck M; Ori A, 2020. Nature protocols. 2020. http://europepmc.org/abstract/med/32737464 . 10.1038/s41596-020-0356-y . Nature protocols
Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery
Bernardo-Castro, Sara; Sousa, João André; Brás, Ana; Cecília, Carla; Rodrigues, Bruno; Almendra, Luciano; Machado, Cristina; et al, 2020. Frontiers in Neurology. 11. 2020. http://dx.doi.org/10.3389/fneur.2020.594672 . 10.3389/fneur.2020.594672 . Frontiers in Neurology
In vitro mechanistic studies on a-amanitin and its putative antidotes
Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02718-1 . 10.1007/s00204-020-02718-1 . Archives of Toxicology
A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies
Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, 2020. Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino, 2020. Nature Reviews Cardiology. 685 - 697. 11. 17. 2020. http://dx.doi.org/10.1038/s41569-020-0389-5 . 10.1038/s41569-020-0389-5 . Nature Reviews Cardiology
Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes
Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02735-0 . 10.1007/s00204-020-02735-0 . Archives of Toxicology
Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.
Ferreira, Lino, 2019. Stem cell reports. 2019. https://europepmc.org/articles/PMC6829749 . 10.1016/j.stemcr.2019.08.002 . Stem cell reports
A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles
Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira, 2019. Nanoscale. 13243 - 13248. 28. 11. 2019. https://doi.org/10.1039/C9NR02512J . 10.1039/C9NR02512J . Nanoscale
Bioprocess decision support tool for scalable manufacture of extracellular vesicles
Ferreira, Lino, 2019. Biotechnology and Bioengineering. 2019. http://dx.doi.org/10.1002/bit.26809 . 10.1002/bit.26809 . Biotechnology and Bioengineering
A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity
Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology
Functional characterization of iPSC-derived arterial- and venous-like endothelial cells
Ferreira, Lino, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-40417-9 . 10.1038/s41598-019-40417-9 . Scientific Reports
A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue
Tian-tian Yao; Jing Wang; Yun-fan Xue; Wei-jiang Yu; Qiang Gao; Lino Ferreira; Ke-Feng Ren; Jian Ji, 2019. Journal of Materials Chemistry B. 2019. https://doi.org/10.1039/C9TB01069F . 10.1039/C9TB01069F . Journal of Materials Chemistry B
Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model
Bernardo Abecasis; Patrícia Gomes-Alves; Susana Rosa; Pedro J. Gouveia; Lino Ferreira; Margarida Serra; Paula M. Alves, 2019. Biotechnology and Bioengineering. 1245 - 1252. 5. 116. 2019. https://doi.org/10.1002/bit.26929 . 10.1002/bit.26929 . Biotechnology and Bioengineering
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Ferreira, Lino, 2019. ACS Nano. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
A near infrared light-triggerable modular formulation for the delivery of small biomolecules
Ferreira, Lino, 2019. Journal of Nanobiotechnology. 2019. http://dx.doi.org/10.1186/s12951-019-0530-y . 10.1186/s12951-019-0530-y . Journal of Nanobiotechnology
A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.
Ferreira, Lino, 2019. Angewandte Chemie (International ed. in English). 2019. https://doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie (International ed. in English)
What human blood-brain barrier models can tell us about BBB function and drug discovery?
Ferreira, Lino, 2019. Expert opinion on drug discovery. 2019. https://doi.org/10.1080/17460441.2019.1646722 . 10.1080/17460441.2019.1646722 . Expert opinion on drug discovery
Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
Neves, Ricardo, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-45352-3 . 10.1038/s41598-019-45352-3 . Scientific Reports
Spatially Confining Surface Roughness on Exponentially Growing Polyelectrolyte Multilayer Films
Ferreira, Lino, 2019. Advanced Materials Interfaces. 2019. http://dx.doi.org/10.1002/admi.201900702 . 10.1002/admi.201900702 . Advanced Materials Interfaces
The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics
Othman, Ziryan; Fernandes, Hugo; Groot, Arjan J.; Luider, Theo M.; Alcinesio, Alessandro; Pereira, Daniel de Melo; Guttenplan, Alexander P.M.; Yuan, Huipin; Habibovic, Pamela, 2019. Biomaterials. 12 - 24. 210. 2019. http://dx.doi.org/10.1016/j.biomaterials.2019.04.021 . 10.1016/j.biomaterials.2019.04.021 . Biomaterials
From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation
Honglin Chen; Danielle F. Baptista; Giuseppe Criscenti; João Crispim; Hugo Fernandes; Clemens van Blitterswijk; Roman Truckenmüller; Lorenzo Moroni, 2019. Nanoscale. 14312 - 14321. 30. 11. 2019. https://doi.org/10.1039/C8NR10108F . 10.1039/C8NR10108F . Nanoscale
A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity
Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 1. 50. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology
Soft-molecular imprinted electrospun scaffolds to mimic specific biological tissues.
Criscenti G; De Maria C; Longoni A; van Blitterswijk CA; Fernandes HAM; Vozzi G; Moroni L, 2018. Biofabrication. 2018. http://europepmc.org/abstract/med/30024388 . 10.1088/1758-5090/aad48a . Biofabrication
Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J., 2018. Nature Communications. 1. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS . 10.1038/s41467-017-02787-4 . Nature Communications
Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Ferreira, Lino, 2018. Cell Reports. 2018. http://dx.doi.org/10.1016/j.celrep.2018.11.032 . 10.1016/j.celrep.2018.11.032 . Cell Reports
Light-triggerable formulations for the intracellular controlled release of biomolecules.
Lino MM; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29326080 . 10.1016/j.drudis.2018.01.019 . Drug discovery today
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
Neves, Ricardo, 2018. Frontiers in Cell and Developmental Biology. 2018. http://dx.doi.org/10.3389/fcell.2018.00103 . 10.3389/fcell.2018.00103 . Frontiers in Cell and Developmental Biology
Stem cells as vehicles and targets of nanoparticles.
Pinho S; Macedo MH; Rebelo C; Sarmento B; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29337203 . 10.1016/j.drudis.2018.01.030 . Drug discovery today
Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation
Neves, Ricardo, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports
Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain
Ferreira, Lino, 2018. Neuroscience Letters. 2018. http://dx.doi.org/10.1016/j.neulet.2018.02.066 . 10.1016/j.neulet.2018.02.066 . Neuroscience Letters
Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics
André F. Ferreira; Michela Comune; Akhilesh Rai; Lino Ferreira; Pedro N. Simões, 2018. The Journal of Physical Chemistry B. 2018. https://doi.org/10.1021/acs.jpcb.8b05717 . 10.1021/acs.jpcb.8b05717 . The Journal of Physical Chemistry B
STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke
Ferreira, Lino, 2018. Frontiers in Neurology. 2018. http://dx.doi.org/10.3389/fneur.2018.00302 . 10.3389/fneur.2018.00302 . Frontiers in Neurology
Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis
Ghebes, Corina Adriana; Groen, Nathalie; Cheuk, Yau Chuk; Fu, Sai Chuen; Fernandes, Hugo Machado; Saris, Daniel B.F., 2018. Tissue Engineering Part A. 322 - 334. 3-4. 24. 2018. http://dx.doi.org/10.1089/ten.tea.2016.0546 . 10.1089/ten.tea.2016.0546 . Tissue Engineering Part A
Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation
Ferreira, Lino, 2018. Advanced Materials Interfaces. 2018. http://dx.doi.org/10.1002/admi.201801390 . 10.1002/admi.201801390 . Advanced Materials Interfaces
MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo
Ferreira, Lino, 2018. PLOS ONE. 2018. http://dx.doi.org/10.1371/journal.pone.0193609 . 10.1371/journal.pone.0193609 . PLOS ONE
Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation
Ferreira, Lino, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports
Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.
Sargento-Freitas J; Aday S; Nunes C; Cordeiro M; Gouveia A; Silva F; Machado C; et al, 2018. Neurology. 2018. http://europepmc.org/abstract/med/29237797 . 10.1212/wnl.0000000000004801 . Neurology
Substrate Topography Modulates Cell Aging on a Progeria Cell Model
Patricia R. Pitrez; Luís Estronca; Helena Vazão; Anne-Laure Egesipe; Amélie Le Corf; Claire Navarro; Nicolas Lévy; et al, 2018. ACS Biomaterials Science & Engineering. 2018. https://doi.org/10.1021/acsbiomaterials.8b00224 . 10.1021/acsbiomaterials.8b00224 . ACS Biomaterials Science & Engineering
Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules
Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.7b00820 . 10.1021/acs.bioconjchem.7b00820 . Bioconjugate Chemistry
Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction.
Crispim JF; Fu SC; Lee YW; Fernandes HAM; Jonkheijm P; Yung PSH; Saris DBF, 2018. The American journal of sports medicine. 2018. http://europepmc.org/abstract/med/30074814 . 10.1177/0363546518787507 . The American journal of sports medicine
Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers
Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira, 2018. ACS Nano. 2018. https://doi.org/10.1021/acsnano.7b07538 . 10.1021/acsnano.7b07538 . ACS Nano
Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics
Ferreira, Lino, 2018. Journal of the Neurological Sciences. 2018. http://dx.doi.org/10.1016/j.jns.2017.12.028 . 10.1016/j.jns.2017.12.028 . Journal of the Neurological Sciences
A nanoformulation for the preferential accumulation in adult neurogenic niches
Ferreira, Lino, 2018. Journal of Controlled Release. 2018. http://dx.doi.org/10.1016/j.jconrel.2018.06.013 . 10.1016/j.jconrel.2018.06.013 . Journal of Controlled Release
Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.
Gouveia PJ; Rosa S; Ricotti L; Abecasis B; Almeida HV; Monteiro L; Nunes J; et al, 2017. Biomaterials. 2017. http://europepmc.org/abstract/med/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials
Restoring heart function and electrical integrity: closing the circuit.
Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29302345 . 10.1038/s41536-017-0015-2 . NPJ Regenerative medicine
Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al, 2017. Small (Weinheim an der Bergstrasse, Germany). 2017. http://europepmc.org/abstract/med/28211642 . 10.1002/smll.201603737 . Small (Weinheim an der Bergstrasse, Germany)
High-throughput identification of small molecules that affect human embryonic vascular development.
Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America
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Fabrication of Bioactive Composite Scaffolds by Electrospinning for Bone Regeneration
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In Vitro and In Vivo Bioluminescent Imaging of Hypoxia in Tissue-Engineered Grafts
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Endogenous Collagen Influences Differentiation of Human Multipotent Mesenchymal Stromal Cells
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cAMP/PKA Signaling Inhibits Osteogenic Differentiation and Bone Formation in Rodent Models
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The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells
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Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice
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Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: Surface characterization and pull-out tests
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Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice
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Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo
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Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (Subtilisin Carlsberg)
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Cr(V) involvement in the toxicity pathway of testicular damage
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Biocatalytic polytransesterification of inulin with divinyladipate
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Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds
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Enzymatic synthesis of dextran-containing hydrogels
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Chromium(VI) induced alterations in mouse spleen cells: A short-term assay
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Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties
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Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values
Ferreira, L.; Vidal, M.M.; Gil, M.H., 2000. International Journal of Pharmaceutics. 169 - 180. 2. 194. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968976&partnerID=MN8TOARS . 10.1016/S0378-5173(99)00375-0 . International Journal of Pharmaceutics
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PARA LICENCIAMENTO - Sistema de entrega de fármacos para a libertação controlada de RNAs
IMPORTÂNCIA: As terapias baseadas em RNA apresentam um leque alargado de aplicações terapêuticas, incluíndo o tratamento de doenças e lesões na pele e oftalmológicas. VANTAGENS: Resolver o principal problema associado ao uso de terapêuticas de RNA (entrega) através de uma rápida e eficiente libertação intracelular de RNAs: rápida entrega para reduzir a sua eliminação do local de administração e um escape endolisossomal eficiente através de um controlo temporal de libertação ativado por luz. APLICAÇÕES: Sistema de entrega de fármacos (biblioteca de nanopartículas) para terapias de RNA para o tratamento de lesões e doenças da pele e doenças oftalmolóficas e intestinais (por laparoscopia).
PARA LICENCIAMENTO - Sistema de Entrega de Editores Genéticos Ativada por Luz
DESCRIÇÃO DA TECNOLOGIA: Sistema de entrega de enzimas de edição genómica ativado por uma luz penetradora de tecidos e capaz de entregar as enzimas funcionais num contexto in vivo e capaz de ser integrado com a optogenética. VANTAGENS: Sistema de entrega de enzimas de edição genómica que combina (i) elevada internalização das enzimas (ii) rápido escape lisossomal (iii) entrega em tecidos profundos (iv) potencial para ser acolpado com estratégias optogenéticas. APLICAÇÕES: - Acoplagem de enzimas de edição genética a estratégias de optogenética no cérebro. - Entrega de enzimas de edição genética tais como a Cre Recombinase para estudos de função de genes e proteínas. - Entrega de enzimas de edição genética tais como CRISPR-Cas e outras proteínas em estadios pré-clínicos ou clínicos (e.g. reprogramação celular). Além das aplicações no cérebro adulto, o nosso sistema de entrega sensível à luz pode ter aplicações em outros tecidos tais como os olhos e o intestino.
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