Publicações
Informação sobre artigos em revista, actualizada a 15-12-2024, a partir da plataforma CIÊNCIAVITAE.
Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3
Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al, Molecular Therapy. 1275 - 1292. 5. 31. 2023. http://dx.doi.org/10.1016/j.ymthe.2023.04.001 . 10.1016/j.ymthe.2023.04.001 . Molecular Therapy
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
Walter, Jonas; Bolognin, Silvia; Poovathingal, Suresh K.; Magni, Stefano; Gérard, Deborah; Antony, Paul M.A.; Nickels, Sarah L.; et al, Cell Reports. 3. 37. 2021. http://dx.doi.org/10.1016/j.celrep.2021.109864 . 10.1016/j.celrep.2021.109864 . published Cell Reports
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality
Walter, Jonas; Bolognin, Silvia; Antony, Paul M.A.; Nickels, Sarah L.; Poovathingal, Suresh K.; Salamanca, Luis; Magni, Stefano; et al, Stem Cell Reports. 878 - 889. 5. 12. 2019. http://dx.doi.org/10.1016/j.stemcr.2019.03.004 . 10.1016/j.stemcr.2019.03.004 . published Stem Cell Reports
Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson's disease cell models
Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Nobre, Rui; Garrido, Manuel; Schwamborn, Jens; De Almeida, Luís, Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00015 . 10.3389/conf.fncel.2019.01.00015 . published Frontiers in Cellular Neuroscience
Optimization of a size-exclusion chromatograhy protocol to isolate plasma-derived extracellular vesicles
Laetitia Gaspar; Magda Santana; Perfeito, Rita; Patrícia Albuquerque; Teresa M. Ribeiro Rodrigues; Henrique Girão; Rui Jorge Nobre; Luís Pereira de Almeida, Journal of Extracellular Vesicles. sup1. 7. 2018. http://dx.doi.org/10.1080/20013078.2018.1461450 . 10.1080/20013078.2018.1461450 . published Journal of Extracellular Vesicles
Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases
Rufino-Ramos, D.; Albuquerque, P.R.; Carmona, V.; Perfeito, R.; Nobre, R.J.; Pereira de Almeida, L., Journal of Controlled Release. 247 - 258. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026758579&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.001 . published Journal of Controlled Release
Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells
Perfeito, R.; Ribeiro, M.; Rego, A.C., Archives of Toxicology. 1245 - 1259. 3. 91. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978795483&partnerID=MN8TOARS . 10.1007/s00204-016-1788-6 . published Archives of Toxicology
Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing a-Synuclein
Noronha, C.; Perfeito, R.; Laço, M.; Wüllner, U.; Rego, A.C., Neurochemical Research. 1430 - 1437. 5. 42. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013849882&partnerID=MN8TOARS . 10.1007/s11064-017-2199-7 . published Neurochemical Research
Autophagy activation prevents alpha-synuclein secretion in exosomes
Perfeito, Rita; Vanessa Anjos; Rui Jorge Nobre; Manuel Garrido; Luís Pereira de Almeida, Journal of Extracellular Vesicles. 1. 5. 2016. http://dx.doi.org/10.3402/jev.v5.31552 . 10.3402/jev.v5.31552 . published Journal of Extracellular Vesicles
Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C., Molecular and Cellular Neuroscience. 51 - 59. 62. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906751686&partnerID=MN8TOARS . 10.1016/j.mcn.2014.08.002 . published Molecular and Cellular Neuroscience
Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse
Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C., Free Radical Biology and Medicine. 186 - 201. 62. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884889978&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2013.05.042 . published Free Radical Biology and Medicine
Role of alpha-synuclein and Parkinson's disease-associated mitochondrial dysfunction,Papel da alfa-sinucleína e da disfunção mitocondrial associada à doença de Parkinson
Perfeito, R.; Rego Prof., A.C., Revista Neurociencias. 273 - 284. 2. 20. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863884807&partnerID=MN8TOARS . published Revista Neurociencias
Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse
Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C., Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867397192&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.08.569 . published Free Radical Biology and Medicine
Iron-Induced Oxidative Stress and Rotenone Modify Alpha-synuclein Phosphorylation in a Cellular Model of Parkinson's Disease
Rita Perfeito; Catarina Resende de Oliveira; Ana Cristina Carvalho Rego, Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.061 . 10.3389/conf.neuro.01.2009.11.061 . published Frontiers in Neuroscience
Alpha-synuclein phosphorylation mediated by iron and rotenone in a cellular model of Parkinson's disease
Perfeito, R.; Oliveira, C.; Rego, A.C., Parkinsonism & Related Disorders. P3.011. 15. 2009. http://dx.doi.org/10.1016/s1353-8020(09)70575-9 . 10.1016/s1353-8020(09)70575-9 . published Parkinsonism & Related Disorders
Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes
Perfeito, R.; Pereira, J.; Oliveira, C.; Bettencourt-Relvas, J.; Rego, A.C., Free Radical Research. 444 - 451. 4. 41. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947493269&partnerID=MN8TOARS . 10.1080/10715760601134442 . published Free Radical Research
5 16 de 16 Publicações
Todos os projectos
Informação da exclusiva responsabilidade do investigador 15-12-2024 , a partir da plataforma CIÊNCIAVITAE.
2023/09/01 -
CinTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
12345
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2023/03/01 - 2024/08/31
Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism
2022.04788.PTDC
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Universidade de Coimbra
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2023/01/01 - 2024/06/30
Conversão Directa de Astrócitos em Neurónios Cerebelares como tratamento Inovador para a Ataxia Espinocerebelosa do Tipo-3
2022.06127.PTDC
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Universidade de Coimbra
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2021/01/01 - 2025/12/31
Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
Researcher
CNC.IBILI
2020/01/01 - 2023/12/31
Centro de Inovação em Biomedicina e Biotecnologia
UIDB/04539/2020
Researcher
CNC.IBILI
2020/08/01 - 2020/10/31
Verão com Ciência: Metodologias de Investigação Científica - I&D: Terapia Génica e Células Estaminais
MIC IIIUC
Researcher
Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Interdisciplinar
Financiadores: Fundação para a Ciência e a Tecnologia
2020/03 - 2022/12
Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy
686213
Principal investigator
2019/01 - 2022/12/31
Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (E-RARE International Consortium)
E-Rare-3 JTC 2017
Researcher
CNC.IBILI
2018/06 - 2022/06/14
The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease
PTDC/BTM-ORG/30737/2017
Researcher
CNC.IBILI
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2018/07 - 2021/06
Role of microRNA deregulation in Machado-Joseph disease: on the development of a microRNA-based therapeutic strategy
PTDC/MED-NEU/32309/2017
Researcher
CNC.IBILI
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2017/01 - 2020/12
Brain Health 2020
CENTRO-01-0145-FEDER-000008
Researcher
CNC.IBILI
2016/05 - 2019/04
Control of cardiomyocyte proliferation in disease and regenerative medicine
PTDC/BIM-MED/3363/2014
Researcher
CNC.IBILI
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2016/01 - 2016/12
Does the transplantation of mutant ataxin-3-depleted patient-derived NSC alleviates Machado Joseph disease (MJD)?
20126
Researcher
CNC.IBILI
Financiadores: AFM-Téléthon
2015/01 - 2018/12
CNC.IBILI
UID/NEU/04539/2013
Researcher
CNC.IBILI
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2015/01 - 2015/12
The transplantation of induced pluripotent stem cells (iPSC)-derived neural stem cells (NSC) in Machado-Joseph disease (MJD)
Research Seed Money Award
Researcher
Centro de Neurociências e Biologia Celular
Financiadores: National Ataxia Foundation
2015/03/01 - 2018/12
Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases - SynSpread (JPND - International Consortium)
JPND SynSpread: CD/0001/2013
Researcher
Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2015/07/01 - 2019/01/31
Role and mechanisms of alpha-synuclein spreading in Parkinson's disease
SFRH/BPD/100130/2014
Post-doc Fellow
Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
2014/09/01 - 2015/06/30
New strategies to manage brain diseases
CENTRO-07-ST24FEDER-002002
Post-doc Fellow
Centro de Neurociências e Biologia Celular; Universidade de Coimbra
Financiadores: Universidade de Coimbra
2014/06/01 - 2014/08/31
Cell to cell transport of alpha-synuclein in Parkinson's disease. The progression factor?
PTDC/SAU-NMC/109955/2009
Post-doc Fellow
Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2011/10 - 2012/07
Alpha-synuclein modifications in peripheral blood lymphocytes from sporadic and familial Parkinson's disease patients
PDCR02
Researcher
Centro de Neurociências e Biologia Celular
Financiadores: Faculdade de Medicina, Universidade de Coimbra
2010/06/01 - 2013/01/31
Deciphering the molecular mechanisms linking alpha-synuclein dysfunction and cytotoxicity in Parkinson's disease - the role of GDNF
Provided by PTCRIS: 101928
Research Technician Fellow
Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2006/06/01 - 2010/05/31
Interplay between alpha-synuclein and oxidative stress in Parkinson's disease cell models
SFRH/BD/25515/2005
PhD Student Fellow
Universidade de Coimbra; Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia, I.P.
5 22 de 22 projetos
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