Visão Geral

Bióloga doutorada (Universidade de Coimbra, 2009). Após obter duas bolsas de posdoc para estudar vários aspectos da infertilidade masculina, a Sandra assegurou o seu primeiro financiamento em 2013 e, mais recentemente em 2018 (~300K€) para estudar em mais detalhe estes aspectos, tendo ganho experiencia na função espermática, bioenergética e espermatogénese. É cientista visitante no Centro de Medicina Reprodutiva e Andrologia na Alemanha. Durante a sua carreia supervisionou vários alunos de mestrado e doutoramento. Tem 32 publicações (h-index 14-google schoolar) e apresentou o seu trabalho em vários congressos, tendo também participado na organização de três deles. De forma aumentar o seu conhecimento a Sandra participou em vários cursos avançados, como por exemplo o curso de experimentação animal ou o IneoStart. Está também envolvida em várias actividades de comunicação de ciência.

Afiliação

CNC/CIBB, III-UC

MITOCHONDRIA-TARGETED COMPOUNDS TO ASSESS AND IMPROVE HUMAN SPERM FUNCTION

Escada-Rebelo, Sara; Cristo, Maria Inês; Ramalho-Santos, Joao; Amaral, Sandra, Antioxidants & Redox Signaling. 2021. http://dx.doi.org/10.1089/ars.2021.0238 . 10.1089/ars.2021.0238 . published Antioxidants & Redox Signaling

The impact of antisperm antibodies on human male reproductive function: an update

Silva, Andreia Filipa; Ramalho-Santos, João; Amaral, Sandra, Reproduction. R55 - R71. 4. 162. 2021. http://dx.doi.org/10.1530/rep-21-0123 . 10.1530/rep-21-0123 . published Reproduction

Can Antidiabetic Drugs Improve Male Reproductive (Dys)Function Associated with Diabetes?

Tavares, Renata S.; Escada-Rebelo, Sara; Sousa, Maria Inês; Silva, Andreia; Ramalho-Santos, João; Amaral, Sandra, Current Medicinal Chemistry. 4191 - 4222. 22. 26. 2019. http://dx.doi.org/10.2174/0929867325666181101111404 . 10.2174/0929867325666181101111404 . published Current Medicinal Chemistry

Raman micro-spectroscopy analysis of different sperm regions: a species comparison

Amaral, Sandra; Da Costa, Raul; Wübbeling, Frank; Redmann, Klaus; Schlatt, S, MHR: Basic science of reproductive medicine. 185 - 202. 4. 24. 2018. http://dx.doi.org/10.1093/molehr/gax071 . 10.1093/molehr/gax071 . published MHR: Basic science of reproductive medicine

Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?

Silva, Andreia; Escada-Rebelo, S.; Amaral, Sandra; Tavares, Renata S.; Schlatt, S; Ramalho-Santos, João; Mota, Paula C, PLoS ONE. 2. 13. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041519878&partnerID=MN8TOARS . 10.1371/journal.pone.0191912 . published PLoS ONE

Spectral features of nuclear DNA in human sperm assessed by Raman Microspectroscopy: Effects of UV-irradiation and hydration

da Costa, Raul; Amaral, Sandra; Redmann, Klaus; Kliesch, S; Schlatt, S., PloS one. e0207786 - e0207786. 11. 13. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056802974&partnerID=MN8TOARS . 10.1371/journal.pone.0207786 . published PloS one

Antidiabetic therapies and male reproductive function: where do we stand? (top dowloaded paper in 2018 on Reproduction Journal)

Tavares, Renata S.; Escada-Rebelo, Sara; Silva, Andreia; Sousa, Maria Inês; Ramalho-Santos, João; Amaral, Sandra, Reproduction (Cambridge, England). R13 - R37. 1. 155. 2017. http://europepmc.org/abstract/med/28993453 . 10.1530/rep-17-0390 . published Reproduction (Cambridge, England)

High glucose levels affect spermatogenesis: an in vitro approach.

Tavares, Renata S.; Portela, J; Sousa, Maria Inês; Mota, Paula C; Ramalho-Santos, João; Amaral, Sandra, Reproduction, Fertility and Development. 1369 - 1378. 7. 29. 2017. http://europepmc.org/abstract/med/27264729 . 10.1071/rd15475 . published Reproduction, Fertility and Development

Mitochondrial Functionality and Chemical Compound Action on Sperm Function

Amaral, Sandra; Tavares, Renata S.; Baptista, Marta; Sousa, Maria Inês; Silva, Andreia; Escada-Rebelo, Sara; Paiva, Carla; Ramalho-Santos, João, Current Medicinal Chemistry. 3575 - 3606. 31. 23. 2016. http://dx.doi.org/10.2174/0929867323666160425113518 . 10.2174/0929867323666160425113518 . published Current Medicinal Chemistry

Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin.

Escada-Rebelo, Sara; Silva, Andreia; Amaral, Sandra; Tavares, Renata S.; Paiva, Carla; Schlatt, S; Ramalho-Santos, João; Mota, Paula C, Andrology. 1159 - 1168. 6. 4. 2016. http://europepmc.org/abstract/med/27317258 . 10.1111/andr.12223 . published Andrology

In vitro exposure to the organochlorine p,p'-DDE affects functional human sperm parameters

Tavares, Renata S.; Amaral, Sandra; Paiva, Carla; Baptista, Marta; Ramalho-Santos, João, Chemosphere. 443 - 446. 120. 2015. http://dx.doi.org/10.1016/j.chemosphere.2014.08.075 . 10.1016/j.chemosphere.2014.08.075 . published Chemosphere

High glucose concentrations per se do not adversely affect human sperm function in vitro

Portela, Joana; Tavares, Renata S.; Mota, Paula C; Ramalho-Santos, João; Amaral, Sandra, REPRODUCTION. 77 - 84. 1. 150. 2015. http://dx.doi.org/10.1530/rep-15-0100 . 10.1530/rep-15-0100 . published REPRODUCTION

Concentration-dependent Sildenafil citrate (Viagra) effects on ROS production, energy status, and human sperm function

Sousa, Maria Inês; Amaral, Sandra; Tavares, Renata S.; Paiva, Carla; Ramalho-Santos, João, Systems Biology in Reproductive Medicine. 72 - 79. 2. 60. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901672805&partnerID=MN8TOARS . 10.3109/19396368.2013.867380 . published Systems Biology in Reproductive Medicine

Mitochondria and mammalian reproduction

Ramalho-Santos, João; Amaral, Sandra, Molecular and Cellular Endocrinology. 74 - 84. 1-2. 379. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884535027&partnerID=MN8TOARS . 10.1016/j.mce.2013.06.005 . published Molecular and Cellular Endocrinology

Aging and male reproductive function: a mitochondrial perspective.

Amaral, Sandra; Ramalho-Santos, João, 181 - 187. S5. 2013. http://europepmc.org/abstract/med/23277044 . 10.2741/s365 . published

UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa

Amaral, Sandra; Redmann, Klaus; Sanchez, V.; Mallidis, Con; Ramalho-Santos, João; Schlatt, S, Andrology. 707 - 714. 5. 1. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883044268&partnerID=MN8TOARS . 10.1111/j.2047-2927.2013.00098.x . published Andrology

Aging, Mitochondria and Male Reproductive Function

Amaral, Sandra; Ramalho-Santos, João, Current Aging Sciencee. 165 - 173. 3. 2. 2009. http://dx.doi.org/10.2174/1874609810902030165 . 10.2174/1874609810902030165 . published Current Aging Sciencee

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

Ramalho-Santos, João; Varum, Sandra; Amaral, Sandra; Mota, Paula C; Ana Paula Sousa; Amaral, Alexandra, Human Reproduction Update. 553 - 572. 5. 15. 2009. http://dx.doi.org/10.1093/humupd/dmp016 . 10.1093/humupd/dmp016 . published Human Reproduction Update

Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)- A model for endangered species

Mota, Paula C; Amaral, Sandra; Martins, Luís; de Lourdes Pereira, Maria; Oliveira, Paulo; Ramalho-Santos, João, Reproductive Toxicology. 111 - 116. 2. 27. 2009. http://dx.doi.org/10.1016/j.reprotox.2009.01.008 . 10.1016/j.reprotox.2009.01.008 . published Reproductive Toxicology

Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats

Amaral, Sandra; Mota, Paula C; Lacerda, Beatriz; Alves, Marco; Pereira, Maria de Lourdes; Oliveira, Paulo; Ramalho-Santos, João, Mitochondrion. 41 - 50. 1. 9. 2009. http://dx.doi.org/10.1016/j.mito.2008.11.005 . 10.1016/j.mito.2008.11.005 . published Mitochondrion

Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species

Ramalho-Santos, João; Amaral, Sandra; Oliveira, Paulo, Current Diabetes Reviews. 46 - 54. 1. 4. 2008. http://dx.doi.org/10.2174/157339908783502398 . 10.2174/157339908783502398 . published Current Diabetes Reviews

Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

Amaral, Sandra; Mota, Paula C; Rodrigues, Ana Sofia; Martins, Luís; Oliveira, Paulo; Ramalho-Santos, João, FEBS Letters. 4191 - 4196. 30. 582. 2008. http://dx.doi.org/10.1016/j.febslet.2008.11.020 . 10.1016/j.febslet.2008.11.020 . published FEBS Letters

Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes

Amaral, Sandra; Moreno, António J.; Santos, Maria Sancha; Seiça, Raquel; Ramalho-Santos, João, Theriogenology. 2056 - 2067. 9. 66. 2006. http://dx.doi.org/10.1016/j.theriogenology.2006.06.006 . 10.1016/j.theriogenology.2006.06.006 . published Theriogenology

Todos os projectos

Mostrar menos

Informação da exclusiva responsabilidade do investigador 16-02-2025 , a partir da plataforma CIÊNCIAVITAE.

2021 - 2025

SR&TD Project - SCHL 394/16-1 " Biochemical and physiological characterization of human spermatozoa using novel optical technologies - A new understanding of sperm functional competence" (400k|3yrs| DGF)

SCHL 394/16-1

Researcher

Universitätsklinikum Münster Centrum für Reproduktionsmedizin und Andrologie

Financiadores: Deutsche Forschungsgemeinschaft

2018 - 2022

SR&TD Project - PTDC/MEC-AND/28599/2017 |(POCI-01-0145-FEDER-028599) (236.679,81 eur, 3 Years, FCT): "Searching for novel biomarkers in unknown origin (UOMI) male infertility"

PTDC/MEC-AND/28599/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2016/01 - 2017/12

Cooperation Project- AI A06/16 (4000 eur, 2 Years, CRUP_DAAD) : "Pesquisa de novos biomarcadores para a infertilidade masculina inexplicada"

AI06/ 16

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universitätsklinikum Münster Centrum für Reproduktionsmedizin und Andrologie

Financiadores: Deutscher Akademischer Austauschdienst; CRUP (Conselho de Reitores das Universidades Portuguesas-Portuguese Council of University Rectors)

2013 - 2015

Cooperation project: Bilateral exchanging program between FCT and DAAD. "Fertility preservation in endangered felids"

n/a

Researcher

Universitätsklinikum Münster Centrum für Reproduktionsmedizin und Andrologie

Financiadores: Deutscher Akademischer Austauschdienst; Fundação para a Ciencia e Tecnologia

2013/01 - 2014/12

Exploratory project - EXPL/BEX-BCM/0224/2012 (48.132 eur, 1.5 year, FCT):"Novel insights into the reproductive dysfunction in diabetes: 3D dimensional analysis of spermatogenesis and analysis of mitochondria status through Confocal Raman Microscopy"

EXPL/BEX-BCM/0224/2012

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciencia e Tecnologia

2012 - 2015

PTDC/EBB-EBI/120634/2010 "Metabolic modulation as a tool to create and propagate pluripotent stem cell lines"

PTDC/EBB-EBI/120634/2010

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2012 - 2015

PTDC/QUI-BIQ/120652/2010 "Role of the pyruvate dehydrogenase Kinase metabolic swith in pluripotency insights into cancer and stem cell biology"

PTDC/QUI-BIQ/120652/2010

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2012 - 2015

PTDC/CVT/119477/2010:"New strategies to recover fertility and genetic variability of endangered felids: development of xenografting and spermatogonial stem cell transplantation in domestic cat as model for endangered felids"

PTDC/CVT/119477/2010

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2010 - 2013

PTDC/EBB­-EBI/101114/2008 " Metabolism as a modulator of stem cell pluripotency and differentiation"

PTDC/EBB­-EBI/101114/2008

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2006 - 2008

III/BIO/50/2005 "What makes a good spermatozoon? a trans-specific perspective" University of coimbra, Instituto de investigação interdisciplinar

III/BIO/50/2005

Other

Universidade de Coimbra

Financiadores: Universidade de Coimbra

Este website utiliza cookies para melhorar a sua experiência.