Metabolismo, Envelhecimento e Doença

Controlo Metabólico

Deutério

Lipogénese

Isotopómeros

Glicogénio

Ciclo de Krebs

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Líder

John Jones

Investigador(a)


Linhas de interesse

Quantificação do metabolismo da frutose pelos adipócitos mesentéricos em modelos de murganhos

Desenvolvimento de água enriquecida com oxigénio-18 como marcador da biossíntese dos hidratos de carbono

Acoplamento dos fluxos da via das pentoses fosfato e da síntese de ácidos gordos em diferentes doenças

Quantificação do metabolismo de nutrientes em peixes cultivados

Visão Geral

Metabolismo intermediário refere-se ao processo intracelular pelo qual os carbonos provenientes dos nutrientes são bioquimicamente transformados para armazenamento ou em produtos celulares estruturais. A nossa missão é o desenvolvimento de metodologias para medir estes processos em sistemas vivos. Os nossos objetivos incluem a aplicação destes meios de análise para compreender melhor o metabolismo dos nutrientes em doenças como a Diabetes Tipo 2 (T2D) e doença hepática gorda não alcoólica (NAFLD), cujo aumento das incidências estão em parte relacionadas com alterações alimentares. A nossas técnicas baseiam-se na utilização de marcadores metabólicos com isótopos estáveis não reativos combinados com ensaios não invasivos de metabolitos chave que traduzem a informação proveniente destes marcadores. A nossa experiência é na utilização de técnicas de ressonância magnética nuclear (RMN) de alta resolução conjuntamente com derivatizações químicas de metabolitos específicos para obter uma informação mais precisa sobre o destino metabólico dos marcadores isotópicos. Isto, por sua vez, leva ao desenvolvimento de modelos de fluxos metabólicos mais detalhados e realísticos para descrever o metabolismo dos nutrientes. Actualmente, estamos focados no metabolismo da frutose no fígado e noutros tecidos. O consumo da frutose nas sociedades ocidentais tem aumentado de forma abrupta durante as recentes décadas e está implicado na vaga de T2D e NAFLD nestas comunidades. A transformação da frutose em ácidos gordos saturados poderá desempenhar um papel importante no aparecimento e progressão dessas doenças.

Publicações

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Informação sobre artigos em revista, actualizada a 17-11-2024, a partir da plataforma CIÊNCIAVITAE.

Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition

Vitor Ferreira; Cintia Folgueira; María García-Altares; Maria Guillén; Mónica Ruíz-Rosario; Giada DiNunzio; Irma Garcia-Martinez; et al, 2023. Redox Biology. 102741 - 102741. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102741 . 10.1016/j.redox.2023.102741 . Redox Biology

Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer

Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241914542 . 10.3390/ijms241914542 . International Journal of Molecular Sciences

Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer

Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010376 . 10.3390/ijms25010376 . International Journal of Molecular Sciences

The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar

João Pessoa; Getachew D. Belew; Cristina Barroso; Conceição Egas; John G. Jones, 2023. Nutrients. 2023. https://doi.org/10.3390/nu15092097 . 10.3390/nu15092097 . Nutrients

A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction

Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G., 2022. NMR in Biomedicine. 2022. https://publons.com/wos-op/publon/50808444/ . 10.1002/NBM.4648 . NMR in Biomedicine

Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage

Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al, 2022. Free Radical Biology and Medicine. 2022. https://publons.com/wos-op/publon/51770689/ . 10.1016/J.FREERADBIOMED.2021.12.304 . Free Radical Biology and Medicine

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A., 2022. European Journal of Clinical Investigation. 2022. https://publons.com/wos-op/publon/49682785/ . 10.1111/ECI.13731 . European Journal of Clinical Investigation

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al, 2022. Redox Biology. 2022. https://publons.com/wos-op/publon/53932683/ . 10.1016/J.REDOX.2022.102400 . Redox Biology

De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers

Getachew Debas Belew; John G. Jones, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13733 . 10.1111/eci.13733 . European Journal of Clinical Investigation

Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice

Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al, 2022. NMR in Biomedicine. 2022. https://publons.com/wos-op/publon/54600422/ . 10.1002/NBM.4837 . NMR in Biomedicine

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

Margarida Coelho; Patarrao RS; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al, 2022. Nutrients. 2022. https://www.mdpi.com/2072-6643/15/1/4 . 10.3390/nu15010004 . Nutrients

Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism

Ivan Viegas; Giada Di Nunzio; Getachew D. Belew; Alejandra N. Torres; João G. Silva; Luis Perpétuo; Cristina Barosa; Ludgero C. Tavares; John G. Jones, 2022. Metabolites. 2022. https://doi.org/10.3390/metabo12111142 . 10.3390/metabo12111142 . Metabolites

Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

John G. Jones, 2021. Metabolites. 751 - 751. 11. 11. 2021. https://doi.org/10.3390/metabo11110751 . 10.3390/metabo11110751 . Metabolites

Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects

Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones, 2021. Journal of Clinical Medicine. 2021. https://doi.org/10.3390/jcm10040596 . 10.3390/jcm10040596 . Journal of Clinical Medicine

Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance

Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G., 2021. NMR in Biomedicine. 2021. https://publons.com/wos-op/publon/50291978/ . 10.1002/NBM.4632 . NMR in Biomedicine

Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells

Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A., 2021. Molecular Neurobiology. 2021. https://publons.com/wos-op/publon/50262822/ . 10.1007/S12035-021-02630-4 . Molecular Neurobiology

Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans

Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al, 2021. The Journal of Clinical Endocrinology & Metabolism. 2021. https://publons.com/wos-op/publon/46827652/ . 10.1210/CLINEM/DGAB100 . The Journal of Clinical Endocrinology & Metabolism

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo, 2021. The Journal of Pathology. 2021. https://publons.com/wos-op/publon/49707570/ . 10.1002/PATH.5777 . The Journal of Pathology

Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits

Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al, 2021. Metabolism. 2021. https://publons.com/wos-op/publon/41702324/ . 10.1016/J.METABOL.2021.154735 . Metabolism

Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases

Sousa-Lima, Ines; Kim, Hyun Jeong; Jones, John; Kim, Young-Bum, 2021. Diabetes & Metabolism Journal. 2021. https://publons.com/wos-op/publon/55608243/ . 10.4093/DMJ.2021.0197 . Diabetes & Metabolism Journal

The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. https://doi.org/10.3390/ijms21155272 . 10.3390/ijms21155272 . International Journal of Molecular Sciences

p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose

Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G., 2020. Analytical Biochemistry. 590. 2020. http://dx.doi.org/10.1016/j.ab.2019.113511 . 10.1016/j.ab.2019.113511 . Analytical Biochemistry

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Jones, John, 2020. Scientific Reports. 2020. http://dx.doi.org/10.1038/s41598-020-69820-3 . 10.1038/s41598-020-69820-3 . Scientific Reports

Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance

Jones, John, 2020. JCI Insight. 2020. http://dx.doi.org/10.1172/jci.insight.134520 . 10.1172/jci.insight.134520 . JCI Insight

Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics

Jones, John, 2020. Frontiers in Physiology. 2020. http://dx.doi.org/10.3389/fphys.2020.00205 . 10.3389/fphys.2020.00205 . Frontiers in Physiology

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose

Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones, 2020. Magnetic Resonance in Medicine. 2765 - 2771. 5. 84. 2020. https://doi.org/10.1002/mrm.28286 . 10.1002/mrm.28286 . Magnetic Resonance in Medicine

Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals

Jones, John, 2020. NMR in Biomedicine. 2020. http://dx.doi.org/10.1002/nbm.4395 . 10.1002/nbm.4395 . NMR in Biomedicine

Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)

Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M., 2019. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 170 - 176. 231. 2019. http://dx.doi.org/10.1016/j.cbpa.2019.02.025 . 10.1016/j.cbpa.2019.02.025 . Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Understanding how birds rebuild fat stores during migration: insights from an experimental study

Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A., 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-46487-z . 10.1038/s41598-019-46487-z . Scientific Reports

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue

Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G., 2019. Metabolic Engineering. 69 - 76. 56. 2019. http://dx.doi.org/10.1016/j.ymben.2019.08.018 . 10.1016/j.ymben.2019.08.018 . Metabolic Engineering

The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata

Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al, 2019. Biomolecules. 297 - 297. 8. 9. 2019. https://doi.org/10.3390/biom9080297 . 10.3390/biom9080297 . Biomolecules

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones, 2019. Journal of Lipid Research. 2050 - 2056. 12. 60. 2019. https://doi.org/10.1194/jlr.RA119000354 . 10.1194/jlr.RA119000354 . Journal of Lipid Research

Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish

Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G., 2019. Aquaculture. 488 - 495. 498. 2019. http://dx.doi.org/10.1016/j.aquaculture.2018.08.066 . 10.1016/j.aquaculture.2018.08.066 . Aquaculture

27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019

Jones, John, 2019. Cardiovascular Endocrinology & Metabolism. 2019. http://dx.doi.org/10.1097/xce.0000000000000179 . 10.1097/xce.0000000000000179 . Cardiovascular Endocrinology & Metabolism

A Mitochondrial Approach to Cardiovascular Risk and Disease

Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, 2019. Current Pharmaceutical Design. 3175 - 3194. 29. 25. 2019. https://doi.org/10.2174/1389203720666190830163735 . 10.2174/1389203720666190830163735 . Current Pharmaceutical Design

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al, 2018. Magnetic Resonance in Medicine. 639 - 644. 1. 81. 2018. http://dx.doi.org/10.1002/mrm.27378 . 10.1002/mrm.27378 . Magnetic Resonance in Medicine

Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets

Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al, 2018. Journal of Proteome Research. 2880 - 2891. 8. 17. 2018. http://dx.doi.org/10.1021/acs.jproteome.8b00354 . 10.1021/acs.jproteome.8b00354 . Journal of Proteome Research

Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream

Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G., 2018. Scientific Reports. 8. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419941000005&KeyUID=WOS:000419941000005 . 10.1038/s41598-017-19087-y . Scientific Reports

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al, 2018. Journal of Clinical Investigation. 5335 - 5350. 12. 128. 2018. https://publons.com/wos-op/publon/19310035/ . 10.1172/JCI63562 . Journal of Clinical Investigation

Improving Metabolic Control Through Functional Foods.

Jones, John G; Silva, Joao C P, 2017. Current medicinal chemistry. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28545368&KeyUID=MEDLINE:28545368 . 10.2174/0929867324666170523130123 . Current medicinal chemistry

Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2

Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A., 2017. Journal of Experimental Biology. 1072 - 1078. 6. 220. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397614200019&KeyUID=WOS:000397614200019 . 10.1242/jeb.150490 . Journal of Experimental Biology

Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype

Flachs, P.; Adamcova, K.; Zouhar, P.; Marques, C.; Janovska, P.; Viegas, I.; Jones, Jg; et al, 2017. International Journal of Obesity. 372 - 380. 3. 41. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395816000003&KeyUID=WOS:000395816000003 . 10.1038/ijo.2016.228 . International Journal of Obesity

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

Hernandez, Elisa Alvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; et al, 2017. Journal of Clinical Investigation. 695 - 708. 2. 127. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000394164100029&KeyUID=WOS:000394164100029 . 10.1172/JCI89444 . Journal of Clinical Investigation

Evidence of extensive plasma glucose recycling following a glucose load in seabass

Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Jones, John G., 2017. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 41 - 48. 211. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406565900006&KeyUID=WOS:000406565900006 . 10.1016/j.cbpa.2017.05.009 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G., 2016. British Journal of Pharmacology. 267 - 278. 2. 173. 2016. https://publons.com/wos-op/publon/2029575/ . 10.1111/BPH.13362 . British Journal of Pharmacology

Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS

Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno, 2016. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376545800032&KeyUID=WOS:000376545800032 . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance

Varghese, Ron T.; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; Rizza, Robert A.; Jones, John G.; Venal, Adrian, 2016. Diabetes. 887 - 892. 4. 65. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372859200008&KeyUID=CCC:000372859200008 . 10.2337/DB15-1593 . Diabetes

Hepatic glucose and lipid metabolism

Jones, John G.; Jones, John G, 2016. Diabetologia. 1098 - 1103. 6. 59. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000378048500004&KeyUID=CCC:000378048500004 . 10.1007/s00125-016-3940-5 . Diabetologia

Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone

Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G.; Jones, John G, 2016. Magnetic Resonance in Medicine. 1781 - 1786. 4. 75. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372910900040&KeyUID=CCC:000372910900040 . 10.1002/mrm.25749 . Magnetic Resonance in Medicine

Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans

Varghese, Ron T.; Man, Chiara Dalla; Sharma, Anu; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; et al, 2016. Journal of Clinical Endocrinology & Metabolism. 4816 - 4824. 12. 101. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000390951000035&KeyUID=WOS:000390951000035 . 10.1210/jc.2016-1998 . Journal of Clinical Endocrinology & Metabolism

Chitosan-Mediated shRNA Knockdown of Cytosolic Alanine Aminotransferase Improves Hepatic Carbohydrate Metabolism

Gonzalez, Juan D.; Silva-Marrero, Jonas I.; Meton, Isidoro; Caballero-Solares, Albert; Viegas, Ivan; Fernandez, Felipe; Minarro, Montserrat; et al, 2016. Marine Biotechnology. 85 - 97. 1. 18. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000378136600007&KeyUID=WOS:000378136600007 . 10.1007/s10126-015-9670-8 . Marine Biotechnology

Determination of muscle protein synthesis rates in fish using (H2O)-H-2 and H-2 NMR analysis of alanine

Marques, Catia; Viegas, Filipa; Rito, Joao; Jones, John; Viegas, Ivan, 2016. Analytical Biochemistry. 111 - 114. 509. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380866800018&KeyUID=WOS:000380866800018 . 10.1016/j.ab.2016.07.011 . Analytical Biochemistry

Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).

Viegas, Ivan; Jarak, Ivana; Rito, Joao; Carvalho, Rui A; Meton, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G, 2016. Journal of lipid research. 1264 - 72. 7. 57. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27247346&KeyUID=MEDLINE:27247346 . 10.1194/jlr.M067850 . Journal of lipid research

Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices

Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G., 2015. Nmr in Biomedicine. 1111 - 1116. 9. 28. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006 . 10.1002/nbm.3355 . Nmr in Biomedicine

Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.)

Viegas, Ivan; Rito, Joao; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Meton, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G., 2015. British Journal of Nutrition. 1345 - 1354. 9. 113. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355283800002&KeyUID=WOS:000355283800002 . 10.1017/S0007114515000574 . British Journal of Nutrition

Reduced alpha-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

Schneeberger, Marc; Gomez-Valades, Alicia G.; Altirriba, Jordi; Sebastian, David; Ramirez, Sara; Garcia, Ainhoa; Esteban, Yaiza; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358324900002&KeyUID=WOS:000358324900002 . 10.1016/j.celrep.2015.06.041 . Cell Reports

Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-C-13] acetate

Burgess, Shawn C.; Merritt, Mathew E.; Jones, John G.; Browning, Jeffrey D.; Sherry, A. Dean; Malloy, Craig R., 2015. Nature Medicine. 20 - 21. 2. 21. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000348974800007&KeyUID=CCC:000348974800007 . 10.1038/NM.3789 . Nature Medicine

Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics

Coelho, Margarida; Nunes, Patricia; Mendes, Vera M.; Manadas, Bruno; Heerschap, Arend; Jones, John G., 2015. Journal of Diabetes Research. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358227400001&KeyUID=WOS:000358227400001 . 10.1155/2015/542029 . Journal of Diabetes Research

Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water

Jones, J.; Kahl, S.; Carvalho, F.; Barosa, C.; Roden, M., 2015. Analytical Biochemistry. 37 - 39. 479. 2015. http://dx.doi.org/10.1016/j.ab.2015.03.018 . 10.1016/j.ab.2015.03.018 . Analytical Biochemistry

Noninvasive stable-isotope tracer methods for the study of hepatic intermediary metabolism

Jones, J. G., 2015. European Journal of Clinical Investigation. 26 - 26. 45. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354124800073&KeyUID=WOS:000354124800073 . European Journal of Clinical Investigation

Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding

Viegas, Ivan; Caballero-Solares, Albert; Rito, Joao; Giralt, Marina; Pardal, Miguel A.; Meton, Isidoro; Jones, John G.; Baanante, Isabel V., 2014. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 38 - 44. 174. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337851700006&KeyUID=WOS:000337851700006 . 10.1016/j.cbpa.2014.04.004 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology

Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice

Nunes, Patricia M.; Wright, Alan J.; Veltien, Andor; van Asten, Jack J. A.; Tack, Cees J.; Jones, John G.; Heerschap, Arend, 2014. Faseb Journal. 1988 - 1997. 5. 28. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000335336000004&KeyUID=CCC:000335336000004 . 10.1096/FJ.13-241208 . Faseb Journal

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

Duarte, Joao A. G.; Carvalho, Filipa; Pearson, Mackenzie; Horton, Jay D.; Browning, Jeffrey D.; Jones, John G.; Burgess, Shawn C., 2014. Journal of Lipid Research. 2541 - 2553. 12. 55. 2014. 10.1194/jlr.M052308 . Journal of Lipid Research

Resolving Futile Glucose Cycling and Glycogenolytic Contributions to Plasma Glucose Levels Following a Glucose Load

Nunes, Patricia M.; Jarak, Ivana; Heerschap, Arend; Jones, John G., 2014. Magnetic Resonance in Medicine. 1368 - 1373. 4. 71. 2014. 10.1002/mrm.24789 . Magnetic Resonance in Medicine

Identifying Sources of Hepatic Lipogenic Acetyl-CoA Using Stable Isotope Tracers and NMR

John G. Jones, 2014. Advances in Radiology. 2014. https://publons.com/wos-op/publon/49841854/ . 10.1155/2014/109252 . Advances in Radiology

Noninvasive measurement of murine hepatic acetyl-CoA C 13 -enrichment following overnight feeding with C 13 -enriched fructose and glucose

Carvalho, F.; Duarte, J.; Simoes, A.R.; Cruz, P.F.; Jones, J.G., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880126867&partnerID=MN8TOARS . 10.1155/2013/638085 . BioMed Research International

Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia

Basu, Rita; Barosa, Cristina; Jones, John; Dube, Simmi; Carter, Rickey; Basu, Ananda; Rizza, Robert A., 2013. Journal of Clinical Endocrinology & Metabolism. E409 - E417. 3. 98. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000316417200001&KeyUID=CCC:000316417200001 . 10.1210/JC.2012-3056 . Journal of Clinical Endocrinology & Metabolism

Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method

Barosa, Cristina; Jones, John G.; Rizza, Robert; Basu, Ananda; Basu, Rita; Barosa, C.; Jones, J.G.; et al, 2013. Magnetic Resonance in Medicine. 315 - 319. 2. 70. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000322128300003&KeyUID=CCC:000322128300003 . 10.1002/mrm.24485 . Magnetic Resonance in Medicine

Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.)

Viegas, I.; Rito, J.; González, J.D.; Jarak, I.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2013. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 399 - 405. 3. 166. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882801986&partnerID=MN8TOARS . 10.1016/j.cbpa.2013.07.013 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Disposition of [U-(2)H7]glucose into hepatic glycogen in rat and in seabass.

Martins, Fatima O; Rito, Joao; Jarak, Ivana; Viegas, Ivan; Pardal, Miguel A; Macedo, M Paula; Jones, John G, 2013. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 316 - 22. 2. 166. 2013. 10.1016/j.cbpa.2013.07.002 . Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes

Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita, 2013. American Journal of Physiology-Endocrinology and Metabolism. E465 - E474. 4. 305. 2013. 10.1152/ajpendo.00245.2013 . American Journal of Physiology-Endocrinology and Metabolism

2H enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis

Delgado, T.C.; Martins, F.O.; Carvalho, F.; Gonçalves, A.; Scott, D.K.; O'Doherty, R.; Paula Macedo, M.; Jones, J.G., 2013. American Journal of Physiology - Endocrinology and Metabolism. 4. 304. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874073240&partnerID=MN8TOARS . 10.1152/ajpendo.00185.2012 . American Journal of Physiology - Endocrinology and Metabolism

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration

Soares, Ana F.; Carvalho, Rui A.; Veiga, Francisco J.; Alves, Marco G.; Martins, Fatima O.; Viegas, Ivan; Gonzalez, Juan D.; et al, 2012. American Journal of Physiology-Endocrinology and Metabolism. E875 - E885. 7. 303. 2012. 10.1152/ajpendo.00161.2012 . American Journal of Physiology-Endocrinology and Metabolism

Glycated hemoglobin and associated risk factors in older adults

Martins, Raul A.; Jones, John G.; Cumming, Sean P.; Coelho e Silva, Manuel J.; Teixeira, Ana M.; Verissimo, Manuel T., 2012. Cardiovascular Diabetology. 11. 2012. 10.1186/1475-2840-11-13 . Cardiovascular Diabetology

Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis

Reis, C.P.; Neufeld, R.; Veiga, F.; Figueiredo, I.V.; Jones, J.; Soares, A.F.; Nunes, P.; Damgé, C.; Carvalho, R.A., 2012. Journal of Microencapsulation. 167 - 176. 2. 29. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863418969&partnerID=MN8TOARS . 10.3109/02652048.2011.638992 . Journal of Microencapsulation

Role of entrapped vapor bubbles during microdroplet evaporation

Putnam, Shawn A.; Byrd, Larry W.; Briones, Alejandro M.; Hanchak, Michael S.; Ervin, Jamie S.; Jones, John G., 2012. Applied Physics Letters. 2012. https://publons.com/wos-op/publon/28925206/ . 10.1063/1.4745009 . Applied Physics Letters

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, Ana P.; Duarte, Filipe V.; Nunes, Patricia; Hubbard, Basil P.; Teodoro, Joao S.; Varela, Ana T.; Jones, John G.; et al, 2012. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 185 - 195. 2. 1822. 2012. 10.1016/j.bbadis.2011.10.008 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes

Viegas, I.; Rito, J.; Jarak, I.; Leston, S.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2012. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 22 - 29. 1. 163. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862836540&partnerID=MN8TOARS . 10.1016/j.cbpa.2012.04.023 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects

Barosa, Cristina; Silva, Claudia; Fagulha, Ana; Barros, Luísa; Caldeira, M. Madalena; Carvalheiro, Manuela; Jones, John G.; et al, 2012. Metabolism. 250 - 254. 2. 61. 2012. http://dx.doi.org/10.1016/j.metabol.2011.06.022 . 10.1016/j.metabol.2011.06.022 . Metabolism

Resolving the Sources of Plasma Glucose Excursions following a Glucose Tolerance Test in the Rat with Deuterated Water and [U-C-13]Glucose

Delgado, Teresa C.; Barosa, Cristina; Nunes, Patricia M.; Cerdan, Sebastian; Geraldes, Carlos F. G. C.; Jones, John G., 2012. Plos One. 3. 7. 2012. 10.1371/journal.pone.0034042 . Plos One

Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat

Delgado, T.C.; Barosa, C.; Nunes, P.M.; Scott, D.K.; O'Doherty, R.M.; Cerdán, S.; Geraldes, C.F.; Jones, J.G., 2012. Expert Opinion on Drug Metabolism and Toxicology. 1223 - 1230. 10. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866515605&partnerID=MN8TOARS . 10.1517/17425255.2012.709500 . Expert Opinion on Drug Metabolism and Toxicology

Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation

Gonzalez, Juan D.; Caballero, Albert; Viegas, Ivan; Meton, Isidoro; Jones, John G.; Barra, Joana; Fernandez, Felipe; Baanante, Isabel V., 2012. British Journal of Nutrition. 1747 - 1756. 12. 107. 2012. 10.1017/S000711451100496X . British Journal of Nutrition

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water

Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052079316&partnerID=MN8TOARS . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Ursodeoxycholic acid treatment of hepatic steatosis: A 13C NMR metabolic study

Nunes, P.M.; Jones, J.G.; Rolo, A.P.; Palmeira, C.M.M.; Carvalho, R.A., 2011. NMR in Biomedicine. 1145 - 1158. 9. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054069550&partnerID=MN8TOARS . 10.1002/nbm.1672 . NMR in Biomedicine

Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes

Kacerovsky, M.; Brehm, A.; Chmelik, M.; Schmid, A.I.; Szendroedi, J.; Kacerovsky-Bielesz, G.; Nowotny, P.; et al, 2011. Journal of Internal Medicine. 189 - 199. 2. 269. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651069103&partnerID=MN8TOARS . 10.1111/j.1365-2796.2010.02298.x . Journal of Internal Medicine

2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine

Silva, A.M.; Martins, F.; Jones, J.G.; Carvalho, R., 2011. Magnetic Resonance in Medicine. 1526 - 1530. 6. 66. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355161597&partnerID=MN8TOARS . 10.1002/mrm.22955 . Magnetic Resonance in Medicine

Transaldolase exchange and its effects on measurements of gluconeogenesis in humans

Basu, Rita; Barosa, Cristina; Basu, Ananda; Pattan, Vishwanath; Saad, Ahmed; Jones, John; Rizza, Robert, 2011. American Journal of Physiology-Endocrinology and Metabolism. E296 - E303. 2. 300. 2011. http://dx.doi.org/10.1152/ajpendo.00403.2010 . 10.1152/ajpendo.00403.2010 . American Journal of Physiology-Endocrinology and Metabolism

Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes

Kacerovsky, M; Jones, J; Schmid, AI; Barosa, C; Lettner, A; Kacerovsky-Bielesz, G; Szendroedi, J; et al, 2011. Diabetes. 1752 - 1758. 6. 60. 2011. 10.2337/db10-1001 . Diabetes

Contribution of proteolytic and metabolic sources to hepatic glutamine by 2H NMR analysis of urinary phenylacetylglutamine 2H-enrichment from 2H2O

Barosa, C.; Almeida, M.; Caldeira, M.M.; Gomes, F.; Jones, J.G., 2010. Metabolic Engineering. 53 - 61. 1. 12. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449718782&partnerID=MN8TOARS . 10.1016/j.ymben.2009.08.009 . Metabolic Engineering

Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis

Soares, Ana F.; Carvalho, Rui A.; Veiga, Francisco J.; Jones, John G., 2010. Metabolic Engineering. 552 - 560. 6. 12. 2010. http://dx.doi.org/10.1016/j.ymben.2010.08.002 . 10.1016/j.ymben.2010.08.002 . Metabolic Engineering

Sources of hepatic glycogen synthesis during an oral glucose tolerance test: Effect of transaldolase exchange on flux estimates

Delgado, Teresa C.; Silva, Claúdia; Fernandes, Isabel; Caldeira, Madalena; Bastos, Margarida; Baptista, Carla; Carvalheiro, Manuela; Geraldes, Carlos F. G. C.; Jones, John G., 2009. Magnetic Resonance in Medicine. 1120 - 1128. 5. 62. 2009. http://dx.doi.org/10.1002/mrm.22107 . 10.1002/mrm.22107 . Magnetic Resonance in Medicine

Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease

Jones, John G.; Garcia, Paula; Barosa, Cristina; Delgado, Teresa C.; Diogo, Luisa, 2009. Metabolic Engineering. 155 - 162. 3. 11. 2009. http://dx.doi.org/10.1016/j.ymben.2009.01.003 . 10.1016/j.ymben.2009.01.003 . Metabolic Engineering

Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat

Delgado, T.C.; Pinheiro, D.; Caldeira, M.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; López-Larrubia, P.; Cerdán, S.; Jones, J.G., 2009. NMR in Biomedicine. 310 - 317. 3. 22. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64949105862&partnerID=MN8TOARS . 10.1002/nbm.826 . NMR in Biomedicine

Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans

Jones, John G.; Garcia, Paula; Barosa, Cristina; Delgado, Teresa C.; Caldeira, M. Madalena; Diogo, Luisa, 2008. Magnetic Resonance in Medicine. 423 - 429. 2. 59. 2008. http://dx.doi.org/10.1002/mrm.21451 . 10.1002/mrm.21451 . Magnetic Resonance in Medicine

Toxicological assessment of orally delivered nanoparticulate insulin

Reis, Catarina P.; Figueiredo, Isabel V.; Carvalho, Rui A.; Jones, John; Nunes, Patricia; Soares, Ana F.; Silva, Cristina F.; et al, 2008. Nanotoxicology. 205 - 217. 4. 2. 2008. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207480800003&KeyUID=WOS:000207480800003 . 10.1080/17435390802398309 . Nanotoxicology

Sources of hepatic glucose production by <sup>2</sup>H<sub>2</sub>O ingestion and Bayesian analysis of <sup>2</sup>H glucuronide enrichment

Delgado, T.C.; Barosa, C.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Bastos, M.; Baptista, C.; Fagulha, A.; et al, 2008. Magnetic Resonance in Medicine. 517 - 523. 3. 60. 2008. http://dx.doi.org/10.1002/mrm.21681 . 10.1002/mrm.21681 . Magnetic Resonance in Medicine

Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions

Soares, Ana F.; Viega, Francisco J.; Carvalho, Rui A.; Jones, John G., 2008. Magnetic Resonance in Medicine. 1 - 5. 1. 61. 2008. http://dx.doi.org/10.1002/mrm.21830 . 10.1002/mrm.21830 . Magnetic Resonance in Medicine

Elimination of glucose contamination from adipocyte glycogen extracts

Nunes, P.M.; Carvalho, E.; Jones, J.G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS . 10.1016/j.carres.2008.04.004 . Carbohydrate Research

Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat

SENA, CM; BAROSA, C; NUNES, E; SEICA, R; JONES, JG, 2007. DIABETES & METABOLISM. 296 - 302. 33. 2007. 10.1016/j.diabet.2007.03.002 . DIABETES & METABOLISM

Estimating gluconeogenesis by NMR isotopomer distribution analysis of [<sup>13</sup>C]bicarbonate and [1-<sup>13</sup>C]lactate

Alves, Tiago Cardoso; Nunes, Patrícia Maria; Palmeira, Carlos Marques; Jones, John Griffith; Carvalho, Rui Albuquerque, 2007. NMR in Biomedicine. 337 - 344. 4. 21. 2007. http://dx.doi.org/10.1002/nbm.1195 . 10.1002/nbm.1195 . NMR in Biomedicine

Toxicological in vivo studies of an oral insulin nanosystern

Reis, Catarina Pinto; Veiga, Francisco; Nunes, Patricia; Soares, Ana Francisca; Laranjeira, Tania; Carvalho, Rui; Jones, John; et al, 2007. Toxicology Letters. S90 - S90. 172. 2007. 10.1016/j.toxlet.2007.05.250 . Toxicology Letters

NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers

Jones, J.; Barosa, C.; Gomes, F.; Carina Mendes, A.; Delgado, T.; Diogo, L.; Garcia, P.; et al, 2006. Journal of Carbohydrate Chemistry. 203 - 217. 2-3. 25. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745133402&partnerID=MN8TOARS . 10.1080/07328300600732840 . Journal of Carbohydrate Chemistry

Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen

Jones, John G.; Fagulha, Ana; Barosa, Cristina; Bastos, Margarida; Barros, Luisa; Baptista, Carla; Caldeira, M. Madalena; Carvalheiro, Manuela, 2006. Diabetes. 2294 - 2300. 8. 55. 2006. http://dx.doi.org/10.2337/db06-0304 . 10.2337/db06-0304 . Diabetes

Hepatic UDP-glucose <sup>13</sup>C isotopomers from [U-<sup>13</sup>C]glucose: A simple analysis by <sup>13</sup>C NMR of urinary menthol glucuronide

Mendes, Ana C.; Caldeira, M. Madalena; Silva, Claudia; Burgess, Shawn C.; Merritt, Matthew E.; Gomes, Filipe; Barosa, Cristina; et al, 2006. Magnetic Resonance in Medicine. 1121 - 1125. 5. 56. 2006. http://dx.doi.org/10.1002/mrm.21057 . 10.1002/mrm.21057 . Magnetic Resonance in Medicine

Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution <sup>1</sup>H NMR spectroscopy

Duarte, Iola F.; Goodfellow, Brian J.; Barros, António; Jones, John G.; Barosa, Cristina; Diogo, Luisa; Garcia, Paula; Gil, Ana M., 2006. NMR in Biomedicine. 401 - 412. 4. 20. 2006. http://dx.doi.org/10.1002/nbm.1073 . 10.1002/nbm.1073 . NMR in Biomedicine

Comparison of [3,4-<sup>13</sup>C<sub>2</sub>]glucose to [6,6-<sup>2</sup>H<sub>2</sub>]glucose as a tracer for glucose turnover by nuclear magnetic resonance

Jin, Eunsook S.; Jones, John G.; Burgess, Shawn C.; Merritt, Matthew E.; Dean Sherry, A.; Malloy, Craig R., 2005. Magnetic Resonance in Medicine. 1479 - 1483. 6. 53. 2005. http://dx.doi.org/10.1002/mrm.20496 . 10.1002/mrm.20496 . Magnetic Resonance in Medicine

Simple measurement of gluconeogenesis by direct <sup>2</sup>H NMR analysis of menthol glucuronide enrichment from <sup>2</sup>H<sub>2</sub>O

Ribeiro, Angela; Caldeira, M. Madalena; Carvalheiro, Manuela; Bastos, Margarida; Baptista, Carla; Fagulha, Ana; Barros, Luisa; Barosa, Cristina; Jones, John G., 2005. Magnetic Resonance in Medicine. 429 - 434. 2. 54. 2005. http://dx.doi.org/10.1002/mrm.20567 . 10.1002/mrm.20567 . Magnetic Resonance in Medicine

Uptake and metabolic effects of insulin mimetic oxovanadium compounds in human erythrocytes

Delgado, T.C.; Tomaz, A.I.; Correia, I.; Costa Pessoa, J.; Jones, J.G.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Journal of Inorganic Biochemistry. 2328 - 2339. 12. 99. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28544439916&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2005.08.014 . Journal of Inorganic Biochemistry

Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis

Fonseca, C.P.; Jones, J.G.; Carvalho, R.A.; Jeffrey, F.M.H.; Montezinho, L.P.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Neurochemistry International. 385 - 393. 6. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24144491138&partnerID=MN8TOARS . 10.1016/j.neuint.2005.06.005 . Neurochemistry International

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative

JIN, ES; JONES, JG; MERRITT, M; BURGESS, SC; MALLOY, CR; SHERRY, AD, 2004. ANALYTICAL BIOCHEMISTRY. 149 - 155. 2. 327. 2004. 10.1006/abio.1998.2796 . ANALYTICAL BIOCHEMISTRY

Quantitation of erythrocyte pentose pathway flux with [2-<sup>13</sup>C]glucose and <sup>1</sup>H NMR analysis of the lactate methyl signal

Delgado, Teresa C.; Castro, M. Margarida; Geraldes, Carlos F.; Jones, John G., 2004. Magnetic Resonance in Medicine. 1283 - 1286. 6. 51. 2004. http://dx.doi.org/10.1002/mrm.20096 . 10.1002/mrm.20096 . Magnetic Resonance in Medicine

Sources of glucose production in cirrhosis by (H2O)-H-2 ingestion and H-2 NMR analysis of plasma glucose

PERDIGOTO, R; FURTADO, AL; PORTO, A; RODRIGUES, TB; GERALDES, CFGC; JONES, JG, 2003. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 156 - 163. 2. 1637. 2003. 10.1016/S0925-4439(03)00018-8 . BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine

Burgess, Shawn C; Weis, Brian; Jones, John G; Smith, Erin; Merritt, Matthew E; Margolis, David; Dean Sherry, A; Malloy, Craig R, 2003. Analytical Biochemistry. 228 - 234. 2. 312. 2003. http://dx.doi.org/10.1016/s0003-2697(02)00465-7 . 10.1016/s0003-2697(02)00465-7 . Analytical Biochemistry

Integration of [U-<sup>13</sup>C]glucose and <sup>2</sup>H<sub>2</sub>O for quantification of hepatic glucose production and gluconeogenesis

Perdigoto, Rui; Rodrigues, Tiago B.; Furtado, Alexandre L.; Porto, Armando; Geraldes, Carlos F. G. C.; Jones, John G., 2003. NMR in Biomedicine. 189 - 198. 4. 16. 2003. http://dx.doi.org/10.1002/nbm.826 . 10.1002/nbm.826 . NMR in Biomedicine

Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl<sub>4</sub> model of acute liver failure

Carvalho, Rui A.; Jones, John G.; McGuirk, Chris; Sherry, A. Dean; Malloy, Craig R., 2002. NMR in Biomedicine. 45 - 51. 1. 15. 2002. http://dx.doi.org/10.1002/nbm.745 . 10.1002/nbm.745 . NMR in Biomedicine

Quantitation of absolute <sup>2</sup>H enrichment of plasma glucose by <sup>2</sup>H NMR analysis of its monoacetone derivative

Jones, John G.; Perdigoto, Rui; Rodrigues, Tiago B.; Geraldes, Carlos F.G.C., 2002. Magnetic Resonance in Medicine. 535 - 539. 3. 48. 2002. http://dx.doi.org/10.1002/mrm.10234 . 10.1002/mrm.10234 . Magnetic Resonance in Medicine

Quantifying tracer levels of (H2O)-H-2 enrichment from microliter amounts of plasma and urine by H-2 NMR

Jones, JG; Merritt, M; Malloy, C, 2001. Magnetic Resonance in Medicine. 156 - 158. 1. 45. 2001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166167400020&KeyUID=WOS:000166167400020 . 10.1002/1522-2594(200101)45:1<156::AID-MRM1020>3.3.CO;2-Q . Magnetic Resonance in Medicine

13C Isotopomer Analysis of Glutamate by J-Resolved Heteronuclear Single Quantum Coherence Spectroscopy

Burgess, Shawn C.; Carvalho, Rui A.; Merritt, Matthew E.; Jones, John G.; Malloy, Craig R.; Sherry, A.Dean, 2001. Analytical Biochemistry. 187 - 195. 2. 289. 2001. http://dx.doi.org/10.1006/abio.2000.4930 . 10.1006/abio.2000.4930 . Analytical Biochemistry

An integrated H-2 and C-13 NMR study of gluconeogenesis and TCA cycle flux in humans

Jones, JG; Solomon, MA; Cole, SM; Sherry, AD; Malloy, CR; Jones, J.G.; Solomon, M.A.; et al, 2001. American Journal of Physiology-Endocrinology and Metabolism. E848 - E856. 4. 281. 2001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171583200025&KeyUID=WOS:000171583200025 . 10.1152/AJPENDO.2001.281.4.E848 . American Journal of Physiology-Endocrinology and Metabolism

Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen

O'Doherty, RM; Jensen, PB; Anderson, P; Jones, JG; Berman, HK; Kearney, D; Newgard, CB; et al, 2000. Journal of Clinical Investigation. 479 - 488. 4. 105. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033995047&partnerID=MN8TOARS . 10.1172/JCI8673 . Journal of Clinical Investigation

Quantitation of Gluconeogenesis by 2H Nuclear Magnetic Resonance Analysis of Plasma Glucose Following Ingestion of 2H2O

Jones, John G.; Carvalho, Rui A.; Sherry, A.Dean; Malloy, Craig R., 2000. Analytical Biochemistry. 121 - 126. 1. 277. 2000. http://dx.doi.org/10.1006/abio.1999.4391 . 10.1006/abio.1999.4391 . Analytical Biochemistry

13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen

Jones, J.G.; Solomon, M.A.; Dean Sherry, A.; Jeffrey, F.M.H.; Malloy, C.R.; Jones, JG; Solomon, MA; et al, 1998. American Journal of Physiology - Endocrinology and Metabolism. E843 - E852. 5 38-5. 275. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032209269&partnerID=MN8TOARS . 10.1152/AJPENDO.1998.275.5.E843 . American Journal of Physiology - Endocrinology and Metabolism

Measurement of Hepatic Glucose Output, Krebs Cycle, and Gluconeogenic Fluxes by NMR Analysis of a Single Plasma Glucose Sample

Jones, John G.; Carvalho, Rui A.; Franco, Byron; Sherry, A.Dean; Malloy, Craig R., 1998. Analytical Biochemistry. 39 - 45. 1. 263. 1998. http://dx.doi.org/10.1006/abio.1998.2796 . 10.1006/abio.1998.2796 . Analytical Biochemistry

Determination of Acetyl-CoA Enrichment in Rat Heart and Skeletal Muscle by1H Nuclear Magnetic Resonance Analysis of Glutamate in Tissue Extracts

Jones, John G.; Hansen, Jim; Sherry, A.Dean; Malloy, Craig R.; Victor, Ronald G., 1997. Analytical Biochemistry. 201 - 206. 2. 249. 1997. http://dx.doi.org/10.1006/abio.1997.2172 . 10.1006/abio.1997.2172 . Analytical Biochemistry

Measurement of gluconeogenesis and pyruvate recycling in the rat liver: A simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate

Jones, J.G.; Naidoo, R.; Sherry, A.D.; Jeffrey, F.M.H.; Cottam, G.L.; Malloy, C.R., 1997. FEBS Letters. 131 - 137. 1. 412. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030754203&partnerID=MN8TOARS . 10.1016/S0014-5793(97)00764-3 . FEBS Letters

Oxidation of lactate and acetate in rat skeletal muscle: Analysis by 13C-nuclear magnetic resonance spectroscopy

Bertocci, L.A.; Jones, J.G.; Malloy, C.R.; Victor, R.G.; Thomas, G.D.; Bertocci, LA; Jones, JG; et al, 1997. Journal of Applied Physiology. 32 - 39. 1. 83. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030844432&partnerID=MN8TOARS . 10.1152/JAPPL.1997.83.1.32 . Journal of Applied Physiology

Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts

JONES, JG; LE, TH; STOREY, CJ; SHERRY, AD; MALLOY, CR; BURTON, KP, 1996. FREE RADICAL BIOLOGY AND MEDICINE. 515 - 523. 4. 20. 1996. 10.1016/0891-5849(95)02088-8 . FREE RADICAL BIOLOGY AND MEDICINE

Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by C-13 isotopomer analysis and O-2 consumption in the heart

MALLOY, CR; JONES, JG; JEFFREY, FM; JESSEN, ME; SHERRY, AD, 1996. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 35 - 46. 1. 4. 1996. 10.1007/BF01759778 . MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

A Method for Obtaining 13C Isotopomer Populations in 13C-Enriched Glucose

Jones, J.G.; Cottam, G.L.; Miller, B.C.; Sherry, A.D.; Malloy, C.R., 1994. Analytical Biochemistry. 148 - 152. 1. 217. 1994. http://dx.doi.org/10.1006/abio.1994.1095 . 10.1006/abio.1994.1095 . Analytical Biochemistry

EFFECTS OF OXIDANT EXPOSURE ON SUBSTRATE UTILIZATION AND HIGH-ENERGY PHOSPHATES IN ISOLATED RAT HEARTS

BURTON, KP; JONES, JG; LE, TH; SHERRY, AD; MALLOY, CR, 1994. Circulation Research. 97 - 104. 1. 75. 1994. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994NV03100012&KeyUID=WOS:A1994NV03100012 . 10.1161/01.RES.75.1.97 . Circulation Research

Orientation-conserved transfer of symmetric krebs cycle intermediates in mammalian tissue

Sherry, A.D.; Sumegi, B.; Miller, B.; Cottam, G.L.; Gavva, S.; Jones, J.G.; Malloy, C.R.; et al, 1994. Biochemistry. 6268 - 6275. 20. 33. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028356902&partnerID=MN8TOARS . 10.1021/bi00186a029 . Biochemistry

Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers

Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R.; JONES, JG; SHERRY, AD; et al, 1993. Biochemistry. 12240 - 12244. 45. 32. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027359228&partnerID=MN8TOARS . 10.1021/bi00096a037 . Biochemistry

METHYLAMINE METABOLISM IN HANSENULA-POLYMORPHA - AN INVIVO C-13 AND P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY

JONES, JG; BELLION, E, 1991. JOURNAL OF BACTERIOLOGY. 4959 - 4969. 16. 173. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GB01400007&KeyUID=WOS:A1991GB01400007 . 10.1128/JB.173.16.4959-4969.1991 . JOURNAL OF BACTERIOLOGY

METHANOL OXIDATION AND ASSIMILATION IN HANSENULA-POLYMORPHA - AN ANALYSIS BY C-13 NMR INVIVO

JONES, JG; BELLION, E, 1991. BIOCHEMICAL JOURNAL. 475 - 481. 280. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GU90100031&KeyUID=WOS:A1991GU90100031 . 10.1042/BJ2800475 . BIOCHEMICAL JOURNAL

INVIVO C-13 AND N-15 NMR-STUDIES OF METHYLAMINE METABOLISM IN PSEUDOMONAS SPECIES MA

JONES, JG; BELLION, E, 1991. JOURNAL OF BIOLOGICAL CHEMISTRY. 11705 - 11713. 18. 266. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991FT76200046&KeyUID=WOS:A1991FT76200046 . JOURNAL OF BIOLOGICAL CHEMISTRY

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