Rosa Maria Branco de Matos Resende

Team icon

Investigador(a)

Resposta do Retículo Endoplasmático (RE) ao stresse e eixo RE-mitocôndria

Patologia amiloide na doença de Alzheimer

E-mail
rresende@cnc.uc.pt
OrcidOpen link icon
Ciencia VitaeOpen link icon
Início O Centro Pessoas

Visão Geral

Rosa Resende is a Biologist (1998), Master in Cell Biology (2002) and received, in 2008, her PhD in Biomedical Sciences from the Faculty of Medicine, University of Coimbra (UC). In 2005 she did a scientific training (6 months) at the University of California (UCLA), USA. After her PhD she had 3 children that impacted her scientific productivity. She is currently doctorate researcher at the Cell Signaling and Metabolism group (Endoplasmic reticulum (ER) stress response and ER-mitochondria axis research line) from the Center for Neuroscience and Cell Biology (CNC), which integrates the Center for Innovative Biomedicine and Biotechnology (CiBB) at UC. Her research has been focused on the study of the cellular and molecular mechanisms of neurodegenerative disorders such as Alzheimer disease and psychiatry disorders such as bipolar disorder and schizophrenia, focusing on disturbances of ER-mitochondria contacts and on pathological deregulation of cellular and organelle stress responses and aiming the discovery of new targets for therapeutic intervention. For these purposes, She has been using in vitro (cell lines and primary cell cultures) and in vivo experimental models (transgenic mice), and human biological samples (blood and skin-derived fibroblasts) due to a fruitful collaboration with the Psychiatry Department of the Coimbra University Hospital. Due to her participation in several funded projects, R Resende published 28 peer-reviewed papers, the majority in international quartile 1 (Q1) journals and one book chapter. In addition, she is inventor of 2 patents, 1 presently under evaluation, demonstrating the relevance of her research in knowledge transfer promotion. The scientific impact of her research is reflected in the H index (17) and high number of citations (more than 1500; Web of Science). Two of her papers are top 10 and one top 5 (NIH percentile). She is a reviewer editor in several scientific journals, and guest editor of one ongoing and one concluded special issues. The articles published under the special issue were compiled in a recently published e-book. In 2017, the project she was developing was awarded with the Bolsa Edgar Cruz e Silva prize 2017 funded by GEECD and SCML. She has supervised 3 MSc and 4 undergraduate students and has been involved in the in the laboratory training of several graduate students (more than 16) in collaboration with MSc courses and PhD Programmes. She was main arguer of 7 MSc theses and she has reviewed papers for several scientific journals and evaluated research proposals from international institutions. To increase her scientific and technical knowledge, she attended many post-graduate courses/workshops at different national and international universities and research institutes of which she highlights the Course in Laboratory Animal Science (Accredited by FELASA, category C). To disseminate her research work she has made several oral communications, some of them by invitation, and participated in diverse (inter)national scientific meetings and has been actively enrolled in scientific outreach activities (member of the organization committee or collaborator), namely Brain Awareness Week, internships during Summer Holidays promoted by Ciência Viva and Fundação para a Ciência e Tecnologia (FCT). and Portuguese Science and Technology Week. She has lso participated in audiovisual material production to boost public awareness to psychiatry diseases such as BD and SCZ, and AD namely, a comic strip, a newspaper column, and interviews. Besides her research activities, She has been Lecturer in the Doctoral Program in Experimental Biology and Biomedicine, Doctoral program in Health Sciences, Master in Biomedical Research, Master in Molecular and Translational Neuroscience, and Integrated Masters in Biomedical Engineering and Medicine from the UC.

Publicações

Mostrar menos

Informação sobre artigos em revista, actualizada a 16-02-2025, a partir da plataforma CIÊNCIAVITAE.

New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice

Rodrigues, Beatriz; Ventura, Eduarda; Moreira, Patrícia; Resende, Rosa; Bicker, Joana; Santos, Armanda E.; Pereira, Cláudia Fragão; et al, Neurobiology of Aging. 105 - 123. 147. 2025. https://doi.org/10.1016/j.neurobiolaging.2024.12.005 . 10.1016/j.neurobiolaging.2024.12.005 . published Neurobiology of Aging

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Moreira, Patrícia; Macedo, Jéssica; Matos, Patrícia; Bicker, Joana; Fortuna, Ana; Figueirinha, Artur; Salgueiro, Lígia; et al, Biomedicine & Pharmacotherapy. 181. 2024. http://dx.doi.org/10.1016/j.biopha.2024.117652 . 10.1016/j.biopha.2024.117652 . published Biomedicine & Pharmacotherapy

Mapping the lipidome in mitochondria-associated membranes (<scp>MAMs</scp>) in an in vitro model of Alzheimer's disease

Fernandes, Tânia; Melo, Tânia; Conde, Tiago; Neves, Bruna; Domingues, Pedro; Resende, Rosa; Pereira, Cláudia F.; Moreira, Paula I.; Domingues, Maria Rosário, Journal of Neurochemistry. 2024. http://dx.doi.org/10.1111/jnc.16072 . 10.1111/jnc.16072 . published Journal of Neurochemistry

Endoplasmic Reticulum-Mitochondria Contacts Modulate Reactive Oxygen Species-Mediated Signaling and Oxidative Stress in Brain Disorders: The Key Role of Sigma-1 Receptor

Resende, Rosa; Fernandes, Tania; Pereira, Ana Catarina; Marques, Ana Patricia; Pereira, Claudia Fragao, Antioxidants & Redox Signaling. 2022. https://publons.com/wos-op/publon/54098042/ . 10.1089/ARS.2020.8231 . Antioxidants & Redox Signaling

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylene A.; et al, Cellular and Molecular Life Sciences. 2022. https://publons.com/wos-op/publon/51936837/ . 10.1007/S00018-022-04211-7 . Cellular and Molecular Life Sciences

Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model

Diana Serra; Joana Henriques; Fábio J. Sousa; Mariana Laranjo; Resende R; Ferreira-Marques, M.; Victor de Freitas; et al, International Journal of Molecular Sciences. 2022. https://www.mdpi.com/1422-0067/23/16/9259 . 10.3390/ijms23169259 . International Journal of Molecular Sciences

Mitochondrial alterations in fibroblasts of early stage bipolar disorder patients

Marques, A.P.; Resende, R.; Silva, D.F.; Batista, M.; Pereira, D.; Wildenberg, B.; Morais, S.; et al, Biomedicines. 5. 9. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106639786&partnerID=MN8TOARS . 10.3390/biomedicines9050522 . Biomedicines

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Fernandes, Tânia; Resende R; Diana F. Silva; Ana P. Marques; AE Santos; Sandra M. Cardoso; Maria Rosario Domingues; Moreira PI; C Pereira, Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/8/881 . 10.3390/biomedicines9080881 . Biomedicines

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPP-ß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models

Resende, Rosa, Journal of Alzheimer's Disease. 2020. https://doi.org/10.3233/JAD-200381 . 10.3233/JAD-200381 . Journal of Alzheimer's Disease

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer's Disease Cellular Models.

Resende, Rosa, International journal of molecular sciences. 2020. https://europepmc.org/articles/PMC7594024 . 10.3390/ijms21207791 . International journal of molecular sciences

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do mitochondria-associated membranes (MAMs) play a role?

Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Bioactivity and safety profile of Daucus carota subsp. maximus essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Gonçalves, M.J.; Lopes, M.C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M.T., Industrial Crops and Products. 218 - 224. 77. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941194381&partnerID=MN8TOARS . 10.1016/j.indcrop.2015.08.037 . Industrial Crops and Products

Daucus carota subsp. gummifer essential oil as a natural source of antifungal and anti-inflammatory drugs.

Resende, Rosa, Industrial Crops and Products. 2015. 10.1016/j.indcrop.2014.11.014 . Industrial Crops and Products

The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer's disease

Resende, Rosa, 2015. 0.1515/ersc-2015-0005 .

Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu

Correia, S.C.; Resende, R.; Moreira, P.I.; Pereira, C.M., DNA and Cell Biology. 261 - 273. 4. 34. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926636149&partnerID=MN8TOARS . 10.1089/dna.2014.2757 . DNA and Cell Biology

Protective effect of leptin and ghrelin against toxicity induced by amyloid-ß oligomers in a hypothalamic cell Line

Gomes, S.; Martins, I.; Fonseca, A.C.R.G.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., Journal of Neuroendocrinology. 176 - 185. 3. 26. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897877226&partnerID=MN8TOARS . 10.1111/jne.12138 . Journal of Neuroendocrinology

Dose-dependent inhibition of BACE-1 by the monoterpenoid 2,3,4,4-tetramethyl-5-methylenecyclopent-2-enone in cellular and mouse models of Alzheimer's disease

Videira, R.; Castanheira, P.; Grãos, M.; Resende, R.; Salgueiro, L.; Faro, C.; Cavaleiro, C., Journal of Natural Products. 1275 - 1279. 6. 77. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903648214&partnerID=MN8TOARS . 10.1021/np400903w . Journal of Natural Products

Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers

Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience

Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F., Neurochemical Research. 797 - 806. 4. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS . 10.1007/s11064-013-0982-7 . Neurochemical Research

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers

Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell

Role of glycogen synthase kinase-3ß on tau phosphorylation in Alzheimer's disease

Resende, R.; Oliveira, C.R.; Pereira, C.M.F., Alzheimer's Disease Research Journal. 193 - 206. 3-4. 3. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-82755187718&partnerID=MN8TOARS . Alzheimer's Disease Research Journal

Multiple defects in energy metabolism in Alzheimer's disease

Ferreira, I.L.; Resende, R.; Ferreiro, E.; Rego, A.C.; Pereira, C.F., Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957994659&partnerID=MN8TOARS . Current Drug Targets

Cholesterol and statins in Alzheimer's disease: Current controversies

Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., Experimental Neurology. 282 - 293. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.09.013 . Experimental Neurology

ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE

Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F., Advances in Medicine and Biology, Vol 2. 197 - 210. 2. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007 . Advances in Medicine and Biology, Vol 2

Neuroprotective effects of statins in an in vitro model of alzheimer's disease

Fonseca, A.C.R.G.; Proena, T.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 503 - 517. 3. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849099662&partnerID=MN8TOARS . 10.3233/JAD-2009-1067 . Journal of Alzheimer's Disease

ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R., Journal of Neuroscience Research. 2091 - 2099. 9. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS . 10.1002/jnr.21648 . Journal of Neuroscience Research

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C., Neuroscience. 725 - 737. 3. 155. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.06.036 . Neuroscience

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease

The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage

Egas, C.; Lavoura, N.; Resende, R.; Brito, R.M.M.; Pires, E.; Pedroso De Lima, M.C.; Faro, C., Journal of Biological Chemistry. 38190 - 38196. 49. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034623993&partnerID=MN8TOARS . 10.1074/jbc.M006093200 . Journal of Biological Chemistry

5 31 de 31 Publicações

Todos os projectos

Mostrar menos

Informação da exclusiva responsabilidade do investigador 16-02-2025 , a partir da plataforma CIÊNCIAVITAE.

2021 - 2021

Bipolar Disease: Another Side. Science communication project

#385-PCC2021

Financiadores: Universidade de Coimbra

2019/01/04 - 2025/01/03

Not Available

DL 57/2016/CP1448/CT0012

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2018 - 2021

InPaCTus sub-project Extracts of high added value from forest biomass¿.

COMPETE2020 nº 21874

Researcher

Financiadores: N/A

2018 - 2021

The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology

CENTRO-01-0145-FEDER-028214

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2018 - 2021

Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease

CENTRO-01-0145-FEDER-029369

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2018 - 2021

Role of anthocyanins from Portuguese blueberries on gut-to-brain connection in autism spectrum disorder by using in vitro and in vivo models

POCI-01-0145-FEDER-029089

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2017 - 2018

New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors.

NA

Post-doc

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Santa Casa da Misericórdia de Lisboa

2015 - 2018

Exosome-mediated glia-neuronal crosstalk upon inflammasome activation in AD

SFRH/BPD/101028/2014

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2013/06 - 2015/06

Tackling Alzheimer's Disease with a new peptide inhibitor of BACE1

126396

Financiadores: Fundação para a Ciência e a Tecnologia, I.P.

2012 - 2015

Development of a new drug for the treatment of Alzheimer's disease

INOV.C

Financiadores: N/A

2012/05 - 2014/10

The impact of exendin-4 therapy in the molecular mechanisms underlying type 2 diabetes-related long-term brain dysfunction

Provided by PTCRIS: 117481

Financiadores: Fundação para a Ciência e a Tecnologia, I.P.

2011/03 - 2013/08

Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease

110990

Financiadores: Fundação para a Ciência e a Tecnologia, I.P.

2010/01 - 2013/06

Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation

102049

Financiadores: Fundação para a Ciência e a Tecnologia, I.P.

2009 - 2015

BETA-AMYLOID AND ALPHA-SYNUCLEIN: TWO PROTEINS, ONE PATHWAY TO ALZHEIMER DISEASE?

SFRH/BPD/34712/2007

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2003 - 2008

Neurotoxicity induced by amyloid-beta peptide. The role of different peptide assemblies.

SFRH/BD/11005/2002

PhD Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

1999 - 2002

Effect of Serine protease from Parietaria judaica pollen in pulmonary epithelium

PRAXIS XXI/BM/19331/99

Master Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

5 16 de 16 projetos

Este website utiliza cookies para melhorar a sua experiência.