Terapias Inovadoras

Proteómica funcional em saúde e doença

Biomarcadores

Investigação Translacional

Proteómica

Metabolómica

Espetrometria de massa

Grandes dados

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Líder

Bruno Manadas

Investigador(a)

Visão Geral

O nosso grupo de investigação desenvolveu abordagens avançadas de espetrometria de massa para serem utilizadas em múltiplas questões biomédicas. As abordagens vão desde a quantificação de pequenas moléculas, como neurotransmissores e metabolitos, até à caraterização do proteoma, identificação de modificações pós-tradução e análise de proteínas intactas para identificar proteoformas. As questões têm-se centrado principalmente na compreensão dos mecanismos da biologia celular através de análises interacadémicas ou proteómicas; na identificação de biomarcadores de doenças diretamente a partir de amostras humanas ou através de abordagens de investigação translacional; na elucidação da modulação cerebral da terapia psicotrópica a longo prazo; e na identificação e quantificação de fármacos e metabolitos na saúde e na doença.

Publicações

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Informação sobre artigos em revista, actualizada a 13-10-2024, a partir da plataforma CIÊNCIAVITAE.

Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics

Moutinho, Daniela; Mendes, Vera M.; Caula, Alessandro; Madeira, Sara C.; Baldeiras, Inês; Guerreiro, Manuela; Cardoso, Sandra; et al, 2024. Translational Neurodegeneration. 1. 13. 2024. http://dx.doi.org/10.1186/s40035-024-00412-1 . 10.1186/s40035-024-00412-1 . published Translational Neurodegeneration

Pine wilt disease: what do we know from proteomics?

Joana Cardoso; MANADAS, BRUNO; Abrantes, I.M.D.O.; ROBERTSON, LEE; Susana Arcos; Maria Teresa Troya; Alfonso Navas; Fonseca, Luís, 2024. BMC Plant Pathology. 2024. https://doi.org/10.1186/s12870-024-04771-9 . published BMC Plant Pathology

A Comparative Analysis of the Venom System between Two Morphotypes of the Sea Anemone Actinia equina

Maria Alcaide; Inês Moutinho Cabral; Lara Carvalho; Vera M. Mendes; António P. Alves de Matos; Bruno Manadas; Leonor Saúde; Mariaelena D’Ambrosio; Pedro M. Costa, 2024. Animals. 2024. https://doi.org/10.3390/ani14060981 . 10.3390/ani14060981 . Animals

Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation

Joana Martins-Macedo; Bruna Araújo; Sandra I. Anjo; Tiago Silveira-Rosa; Patrícia Patrício; Nuno Dinis Alves; Joana M. Silva; et al, 2024. Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02490-z . 10.1038/s41380-024-02490-z . Molecular Psychiatry

Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture

Marote, A.; Santos, D.; Mendes-Pinheiro, B.; Serre-Miranda, C.; Anjo, S.I.; Vieira, J.; Ferreira-Antunes, F.; et al, 2023. Stem Cell Reviews and Reports. 248 - 263. 1. 19. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85138719382&partnerID=MN8TOARS . 10.1007/s12015-022-10453-6 . Stem Cell Reviews and Reports

A peptide-centric approach to analyse quantitative proteomics data- an application to prostate cancer biomarker discovery

Lima, T.; Rodrigues, J.E.; Manadas, B.; Henrique, R.; Fardilha, M.; Vitorino, R., 2023. Journal of Proteomics. 272. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142764157&partnerID=MN8TOARS . 10.1016/j.jprot.2022.104774 . Journal of Proteomics

Enrichment of hepatic glycogen and plasma glucose from H2 18 O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice

Margarida Coelho; Rohit Mahar; Getachew D. Belew; Alejandra Torres; Cristina Barosa; Fernando Cabral; Ivan Viegas; et al, 2023. NMR in Biomedicine. 2023. https://doi.org/10.1002/nbm.4837 . 10.1002/nbm.4837 . NMR in Biomedicine

Biomarkers of hypoxic–ischemic encephalopathy: a systematic review

Inês Caramelo; Margarida Coelho; Miguel Rosado; Carla M. P. Cardoso; Alexandra Dinis; Carlos B. Duarte; Mário Grãos; Bruno Manadas, 2023. World Journal of Pediatrics. 2023. https://doi.org/10.1007/s12519-023-00698-7 . 10.1007/s12519-023-00698-7 . World Journal of Pediatrics

Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer

Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241914542 . 10.3390/ijms241914542 . International Journal of Molecular Sciences

An Exploration of Novel Bioactives from the Venomous Marine Annelid Glycera alba

Sónia Campos; Ana P. Rodrigo; Inês Moutinho Cabral; Vera M. Mendes; Bruno Manadas; Mariaelena D’Ambrosio; Pedro M. Costa, 2023. Toxins. 2023. https://doi.org/10.3390/toxins15110655 . 10.3390/toxins15110655 . Toxins

New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimodal Approach

Rita I. Pacheco; Maria I. Cristo; Sandra Anjo; Silva, Andreia F; Maria Inês Sousa; Renata S. Tavares; Ana Paula Sousa; et al, 2023. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/10/1462 . 10.3390/biom13101462 . Biomolecules

Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models

Beatriz Caramelo; Tamaeh Monteiro-Alfredo; João Martins; José Sereno; João Castelhano; Bruno Manadas; Miguel Castelo-Branco; Paulo Matafome, 2023. Journal of Neurochemistry. 2023. https://doi.org/10.1111/jnc.15825 . 10.1111/jnc.15825 . Journal of Neurochemistry

Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer

Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010376 . 10.3390/ijms25010376 . International Journal of Molecular Sciences

Proteomic and Metabolic Analysis of Pinus halepensis Mill. Embryonal Masses Induced under Heat Stress

Cátia Pereira; Ander Castander-Olarieta; Itziar A. Montalbán; Vera M. Mendes; Sandra Correia; Ana Pedrosa; Bruno Manadas; Paloma Moncaleán; Jorge Canhoto, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24087211 . 10.3390/ijms24087211 . International Journal of Molecular Sciences

Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol

Pinto, P.I.; Anjos, L.; Estêvão, M.D.; Santos, S.; Santa, C.; Manadas, B.; Monsinjon, T.; Canário, A.V.M.; Power, D.M., 2022. Science of the Total Environment. 814. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122305160&partnerID=MN8TOARS . 10.1016/j.scitotenv.2021.152671 . Science of the Total Environment

Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues for Biotechnology

Ana P. Rodrigo; Ana Lopes; Ricardo Pereira; Sandra I. Anjo; Bruno Manadas; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa, 2022. Marine Drugs. 224 - 224. 4. 20. 2022. https://doi.org/10.3390/md20040224 . 10.3390/md20040224 . Marine Drugs

Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model

Inês Serrenho; Carla M. Cardoso; Mário Grãos; Alexandra Dinis; Bruno Manadas; Graça Baltazar, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms24010257 . 10.3390/ijms24010257 . International Journal of Molecular Sciences

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

Margarida Coelho; Rita S. Patarrão; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al, 2022. Nutrients. 2022. https://doi.org/10.3390/nu15010004 . 10.3390/nu15010004 . Nutrients

Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression

Ana Pinto; Ana Beatriz Machado; Hugo Osorio; Marta Laranjeiro Pinto; Vitorino, R.; Gonçalo C. Justino; Cátia Santa; et al, 2022. Cancers. 2022. https://www.mdpi.com/2072-6694/15/1/270 . 10.3390/cancers15010270 . Cancers

Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice

Diana Rodrigues; Luis Jacinto; Margarida Falcão; Ana Carolina Castro; Alexandra Cruz; Cátia Santa; Bruno Manadas; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-35028-4 . 10.1038/s41467-022-35028-4 . Nature Communications

Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature

Ana Filipa Fernandes; Luís Gafeira Gonçalves; Maria Bento; Sandra I. Anjo; Bruno Manadas; Clara Barroso; Miguel Villar; et al, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232213733 . 10.3390/ijms232213733 . International Journal of Molecular Sciences

Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis

Salazar, I.L.; Lourenço, A.S.T.; Manadas, B.; Baldeiras, I.; Ferreira, C.; Teixeira, A.C.; Mendes, V.M.; et al, 2022. Journal of Neuroinflammation. 1. 19. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124466899&partnerID=MN8TOARS . 10.1186/s12974-022-02404-2 . Journal of Neuroinflammation

Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia

João E. Rodrigues; Ana Martinho; Catia Santa; Nuno Madeira; Manuel Coroa; Vítor Santos; Maria J. Martins; et al, 2022. International Journal of Molecular Sciences. 4917 - 4917. 9. 23. 2022. https://doi.org/10.3390/ijms23094917 . 10.3390/ijms23094917 . International Journal of Molecular Sciences

Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure

Fábio Trindade; Ana F. Ferreira; Francisca Saraiva; Diana Martins; Vera M. Mendes; Carla Sousa; Cristina Gavina; et al, 2022. Proteomes. 2022. https://doi.org/10.3390/proteomes10030030 . 10.3390/proteomes10030030 . Proteomes

COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection

Eduardo Esteves; Vera M. Mendes; Bruno Manadas; Rafaela Lopes; Liliana Bernardino; Maria José Correia; Marlene Barros; Ana Cristina Esteves; Nuno Rosa, 2022. Journal of Clinical Medicine. 2022. https://doi.org/10.3390/jcm11195571 . 10.3390/jcm11195571 . Journal of Clinical Medicine

Virulence Biomarkers of Bursaphelenchus xylophilus: A Proteomic Approach

Cardoso, J.M.S.; Anjo, S.I.; Manadas, B.; Silva, H.; Abrantes, I.; Nakamura, K.; Fonseca, L., 2022. Frontiers in Plant Science. 12. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125060046&partnerID=MN8TOARS . 10.3389/fpls.2021.822289 . Frontiers in Plant Science

Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis

Mancio, J.; Sousa-Nunes, F.; Martins, R.; Fragao-Marques, M.; Conceicao, G.; Pessoa-Amorim, G.; Barros, A.S.; et al, 2022. European Heart Journal Cardiovascular Imaging. 1248 - 1259. 9. 23. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136182913&partnerID=MN8TOARS . 10.1093/ehjci/jeac092 . European Heart Journal Cardiovascular Imaging

Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway

Magalhães, M.; Domínguez-Martín, E.M.; Jorge, J.; Gonçalves, A.C.; Díaz-Lanza, A.M.; Manadas, B.; Efferth, T.; Rijo, P.; Cabral, C., 2022. Frontiers in Pharmacology. 13. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140619586&partnerID=MN8TOARS . 10.3389/fphar.2022.1006832 . Frontiers in Pharmacology

More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium

Guatelli, S.; Ferrario, C.; Bonasoro, F.; Anjo, S.I.; Manadas, B.; Candia Carnevali, M.D.; Varela Coelho, A.; Sugni, M., 2022. Cell and Tissue Research. 207 - 227. 2. 390. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137783059&partnerID=MN8TOARS . 10.1007/s00441-022-03678-x . Cell and Tissue Research

Effects of microplastics alone and with adsorbed benzo(a)pyrene on the gills proteome of Scrobicularia plana

Bebianno, M.J.; Mendes, V.M.; O'Donovan, S.; Carteny, C.C.; Keiter, S.; Manadas, B., 2022. Science of the Total Environment. 842. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85133432069&partnerID=MN8TOARS . 10.1016/j.scitotenv.2022.156895 . Science of the Total Environment

Modulation of signaling pathways by DJ-1: An updated overview

Neves, M.; Grãos, M.; Anjo, S.I.; Manadas, B.; Margarida Neves; Mario Graos; Sandra Anjo; MANADAS, BRUNO, 2022. Redox Biology. 51. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126516555&partnerID=MN8TOARS . 10.1016/j.redox.2022.102283 . accepted Redox Biology

Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluoxetine and estradiol

Anjos, L.; Pinto, P.I.S.; Santos, S.; Estêvão, M.D.; Santa, C.; Manadas, B.; Canário, A.V.M.; Power, D.M., 2022. Data in Brief. 41. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122311143&partnerID=MN8TOARS . 10.1016/j.dib.2022.107971 . Data in Brief

Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system

Guimarães, M.R.; Anjo, S.I.; Cunha, A.M.; Esteves, M.; Sousa, N.; Almeida, A.; Manadas, B.; Leite-Almeida, H., 2021. Pain. 1722 - 1731. 6. 162. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106543286&partnerID=MN8TOARS . 10.1097/j.pain.0000000000002192 . Pain

Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma

Magalhães, M.; Manadas, B.; Efferth, T.; Cabral, C., 2021. Pharmacological Research. 169. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105057870&partnerID=MN8TOARS . 10.1016/j.phrs.2021.105638 . Pharmacological Research

Disclosing proteins in the leaves of cork oak plants associated with the immune response to Phytophthora cinnamomi inoculation in the roots: A long-term proteomics approach

Coelho, A.C.; Pires, R.; Schutz, G.; Santa, C.; Manadas, B.; Pinto, P., 2021. PLoS ONE. 1 January. 16. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100319358&partnerID=MN8TOARS . 10.1371/journal.pone.0245148 . PLoS ONE

Comparative Analysis of Bursaphelenchus xylophilus Secretome Under Pinus pinaster and P. pinea Stimuli

Silva, H.; Anjo, S.I.; Manadas, B.; Abrantes, I.; Fonseca, L.; Cardoso, J.M.S., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107053724&partnerID=MN8TOARS . 10.3389/fpls.2021.668064 . Frontiers in Plant Science

Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses

Curto, P.; Santa, C.; Cortes, L.; Manadas, B.; Simões, I., 2021. Microbiology Spectrum. 3. 9. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123813061&partnerID=MN8TOARS . 10.1128/SPECTRUM.00814-21 . Microbiology Spectrum

Metabolic parameters as possible diagnostic predictors in first-episode psychosis: An exploratory retrospective cohort study

Sofia Ramos Ferreira; Diana Moura; Pedro Oliveira; Vítor Santos; Miguel Bajouco; Sofia Morais; Manuel Coroa; Bruno Manadas; Nuno Madeira, 2021. Early Intervention in Psychiatry. 2021. https://doi.org/10.1111/eip.13257 . 10.1111/eip.13257 . Early Intervention in Psychiatry

Proteome-Wide Analysis of Heat-Stress in Pinus radiata Somatic Embryos Reveals a Combined Response of Sugar Metabolism and Translational Regulation Mechanisms

Castander-Olarieta, A.; Pereira, C.; Montalbán, I.A.; Mendes, V.M.; Correia, S.; Suárez-Álvarez, S.; Manadas, B.; Canhoto, J.; Moncaleán, P., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104978818&partnerID=MN8TOARS . 10.3389/fpls.2021.631239 . Frontiers in Plant Science

The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, 2021. Cancers. 3052 - 3052. 12. 13. 2021. https://doi.org/10.3390/cancers13123052 . 10.3390/cancers13123052 . Cancers

Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells

Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes, 2021. Marine Drugs. 2021. https://doi.org/10.3390/md19010031 . 10.3390/md19010031 . Marine Drugs

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, 2021. Nano Today. 101095 - 101095. 37. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Hypoxia and Hypoxia-Inducible Factor-1a Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion

Novais, E.J.; Choi, H.; Madhu, V.; Suyama, K.; Anjo, S.I.; Manadas, B.; Shapiro, I.M.; Salgado, A.J.; Risbud, M.V., 2021. American Journal of Pathology. 487 - 502. 3. 191. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099523691&partnerID=MN8TOARS . 10.1016/j.ajpath.2020.11.012 . American Journal of Pathology

Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies

Inês Serrenho; Miguel Rosado; Alexandra Dinis; Carla M. Cardoso; Mário Grãos; Bruno Manadas; Graça Baltazar, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22063142 . 10.3390/ijms22063142 . International Journal of Molecular Sciences

FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis

Ferreira, D.; Escudeiro, A.; Adega, F.; Anjo, S.I.; Manadas, B.; Chaves, R., 2020. Cellular and Molecular Life Sciences. 1371 - 1386. 7. 77. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069637568&partnerID=MN8TOARS . 10.1007/s00018-019-03234-x . Cellular and Molecular Life Sciences

A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

Anjo, Sandra I.; dos Santos, Patrícia Valério; Rosado, Luiza; Baltazar, Graça; Baldeiras, Inês; Pires, Diana; Gomes, Andreia; et al, 2020. Translational Neurodegeneration. 1. 9. 2020. http://dx.doi.org/10.1186/s40035-020-00188-0 . 10.1186/s40035-020-00188-0 . published Translational Neurodegeneration

Comparative proteomic analysis of nodulated and non-nodulated Casuarina glauca Sieb. ex Spreng. grown under salinity conditions using sequential window acquisition of all theoretical mass spectra (SWATH-MS)

Graça, Inês; Mendes, Vera M.; Marques, Isabel; Duro, Nuno; Costa, Mário; Ramalho, José C.; Pawlowski, Katharina; et al, 2020. International Journal of Molecular Sciences. 78 - 78. 1. 21. 2020. http://hdl.handle.net/10400.5/19224 . 10.3390/ijms21010078 . International Journal of Molecular Sciences

Cofilin-1 is a mechanosensitive regulator of transcription

Domingues, Catarina; Geraldo, A Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; et al, 2020. 2020. http://hdl.handle.net/10773/30552 . 10.3389/fcell.2020.00678 .

Proteomics-based Predictive Model for the Early Detection of Metastasis and Recurrence in Head and Neck Cancer

Ribeiro, I.P.; Esteves, L.; Anjo, S.I.; Marques, F.; Barroso, L.; Manadas, B.; Carreira, I.M.; Melo, J.B., 2020. Cancer Genomics and Proteomics. 259 - 269. 3. 17. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084169410&partnerID=MN8TOARS . 10.21873/cgp.20186 . Cancer Genomics and Proteomics

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C., 2020. Frontiers in Cell and Developmental Biology. 8. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS . 10.3389/fcell.2020.576592 . Frontiers in Cell and Developmental Biology

Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project

Francisca A. de Leeuw; Wiesje M. van der Flier; Betty M. Tijms; Philip Scheltens; Vera M. Mendes; Bruno Manadas; Jörgen Bierau; et al, 2020. Journal of the American Medical Directors Association. 2020. https://doi.org/10.1016/j.jamda.2019.12.009 . 10.1016/j.jamda.2019.12.009 . Journal of the American Medical Directors Association

Epicardial adipose tissue volume and annexin A2/fetuin-A signalling are linked to coronary calcification in advanced coronary artery disease: Computed tomography and proteomic biomarkers from the EPICHEART study

Mancio, J.; Barros, A.S.; Conceicao, G.; Pessoa-Amorim, G.; Santa, C.; Bartosch, C.; Ferreira, W.; et al, 2020. Atherosclerosis. 75 - 83. 292. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075496821&partnerID=MN8TOARS . 10.1016/j.atherosclerosis.2019.11.015 . Atherosclerosis

Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis,Influência do Tecido Adiposo Epicárdico nas Doenças Cardíacas (EPICHEART): protocolo para um estudo de translação em aterosclerose coronário

Mancio, J.; Barros, A.S.; Conceicão, G.; Santa, C.; Pessoa-Amorim, G.; Bartosch, C.; Fragao-Marques, M.; et al, 2020. Revista Portuguesa de Cardiologia. 625 - 633. 11. 39. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095788788&partnerID=MN8TOARS . 10.1016/j.repc.2020.03.017 . Revista Portuguesa de Cardiologia

Analytical methods to monitor dopamine metabolism in plasma: Moving forward with improved diagnosis and treatment of neurological disorders

Abrantes Dias, A.S.; Amaral Pinto, J.C.; Magalhães, M.; Mendes, V.M.; Manadas, B., 2020. Journal of Pharmaceutical and Biomedical Analysis. 187. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085476273&partnerID=MN8TOARS . 10.1016/j.jpba.2020.113323 . Journal of Pharmaceutical and Biomedical Analysis

Changes in the salivary proteome of beagle dogs after weight loss

Lucena, S.; Coelho, A.V.; Muñoz-Prieto, A.; Anjo, S.I.; Manadas, B.; Capela e Silva, F.; Lamy, E.; Tvarijonaviciute, A., 2020. Domestic Animal Endocrinology. 72. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083877714&partnerID=MN8TOARS . 10.1016/j.domaniend.2020.106474 . Domestic Animal Endocrinology

The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. https://doi.org/10.3390/ijms21155272 . 10.3390/ijms21155272 . International Journal of Molecular Sciences

Proteomic Analyses Reveal New Insights on the Antimicrobial Mechanisms of Chitosan Biopolymers and Their Nanosized Particles against Escherichia coli

Laidson P. Gomes; Sandra I. Anjo; Bruno Manadas; Ana V. Coelho; Vania M. F. Paschoalin, 2019. International Journal of Molecular Sciences. 2019. https://doi.org/10.3390/ijms21010225 . 10.3390/ijms21010225 . International Journal of Molecular Sciences

Experimental data from flesh quality assessment and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets

Anjos, Liliana; Pinto, Patricia IS; Tsironi, Theofania; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13462 . 10.1016/j.dib.2019.104451 .

Analysis of the quantitative proteomic signature in PBMCs of first-episode psychosis patients

Santa, Cátia; Coroa, Manuel; Morais, Sofia; Bajouco, Miguel; Anjo, Sandra; Baldeiras, Ines; Madeira, Nuno; Macedo, António; MANADAS, BRUNO, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00005 . 10.3389/conf.fncel.2019.01.00005 . published Frontiers in Cellular Neuroscience

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

Soares, A.; Niedermaier, S.; Faro, R.; Loos, A.; Manadas, B.; Faro, C.; Huesgen, P.F.; Cheung, A.Y.; Simões, I., 2019. Journal of Experimental Botany. 2157 - 2171. 7. 70. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068490019&partnerID=MN8TOARS . 10.1093/jxb/erz059 . Journal of Experimental Botany

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve

Vera M. Mendes; Margarida Coelho; Angelo R. Tomé; Rodrigo A. Cunha; Bruno Manadas, 2019. Molecules. 2019. https://doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules

Comparative proteomic analysis of saliva from dogs with and without obesity-related metabolic dysfuntion

Sónia Lucena; Ana Varela Coelho; Sandra I. Anjo; Bruno Manadas; Vladimir Mrljak; Fernando Capela e Silva; Elsa Lamy; Asta Tvarijonaviciute, 2019. Journal of Proteomics. 65 - 72. 201. 2019. https://doi.org/10.1016/j.jprot.2019.04.010 . 10.1016/j.jprot.2019.04.010 . Journal of Proteomics

High pressure processing of European sea bass (Dicentrarchus labrax) fillets and tools for flesh quality and shelf life monitoring

Tsironi, Theofania; Anjos, Liliana; Pinto, Patricia IS; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13638 . 10.1016/j.jfoodeng.2019.05.010 .

Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model

Pinheiro, Bárbara Filipa Mendes; Anjo, Sandra I.; Manadas, Bruno; da Silva, Jorge D.; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Teixeira, Fábio G.; Salgado, A. J., 2019. 2019. http://hdl.handle.net/1822/67311 . 10.3389/fbioe.2019.00294 .

Pre-analytical stability of novel cerebrospinal fluid biomarkers

Willemse, E.A.J.; Vermeiren, Y.; Garcia-Ayllon, M.-S.; Bridel, C.; De Deyn, P.P.; Engelborghs, S.; van der Flier, W.M.; et al, 2019. Clinica Chimica Acta. 204 - 211. 497. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069842833&partnerID=MN8TOARS . 10.1016/j.cca.2019.07.024 . Clinica Chimica Acta

Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment

Anjo, S.I.; Simões, I.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Talanta. 205. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069659407&partnerID=MN8TOARS . 10.1016/j.talanta.2019.120163 . Talanta

Changes in the intestinal mucosal proteome of turkeys (Meleagris gallopavo) infected with haemorrhagic enteritis virus

Marques, A.T.; Anjo, S.I.; Bhide, M.; Varela Coelho, A.; Manadas, B.; Lecchi, C.; Grilli, G.; Ceciliani, F., 2019. Veterinary Immunology and Immunopathology. 213. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067345000&partnerID=MN8TOARS . 10.1016/j.vetimm.2019.06.001 . Veterinary Immunology and Immunopathology

Meningeal ¿d T cell-derived IL-17 controls synaptic plasticity and short-term memory

Ribeiro, M.; Brigas, H.C.; Temido-Ferreira, M.; Pousinha, P.A.; Regen, T.; Santa, C.; Coelho, J.E.; et al, 2019. Science Immunology. 40. 4. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073157928&partnerID=MN8TOARS . 10.1126/sciimmunol.aay5199 . Science Immunology

oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening

Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Mário Grãos; Bruno Manadas, 2019. Redox Biology. 101130 - 101130. 2019. https://doi.org/10.1016/j.redox.2019.101130 . 10.1016/j.redox.2019.101130 . Redox Biology

Proteomics and antioxidant enzymes reveal different mechanisms of toxicity induced by ionic and nanoparticulate silver in bacteria

Barros, D.; Pradhan, A.; Mendes, V.M.; Manadas, B.; Santos, P.M.; Pascoal, C.; Cássio, F., 2019. Environmental Science: Nano. 1207 - 1218. 4. 6. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064263150&partnerID=MN8TOARS . 10.1039/c8en01067f . Environmental Science: Nano

Corrigendum to “oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening” (Redox Biology (2019) 22, (S2213231718311856), (10.1016/j.redox.2019.101130))

Anjo, S.I.; Melo, M.N.; Loureiro, L.R.; Sabala, L.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Redox Biology. 26. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067256447&partnerID=MN8TOARS . 10.1016/j.redox.2019.101257 . Redox Biology

A pathogen and a non-pathogen spotted fever group rickettsiatrigger differential proteome signatures in macrophages

Curto, P.; Santa, C.; Allen, P.; Manadas, B.; Simões, I.; Martinez, J.J., 2019. Frontiers in Cellular and Infection Microbiology. MAR. 9. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063647273&partnerID=MN8TOARS . 10.3389/fcimb.2019.00043 . Frontiers in Cellular and Infection Microbiology

A translational view of cells' secretome analysis - from untargeted proteomics to potential circulating biomarkers

Anjo, S.I.; Manadas, B., 2018. Biochimie. 37 - 49. 155. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048135989&partnerID=MN8TOARS . 10.1016/j.biochi.2018.05.007 . Biochimie

Elucidation of the dynamic nature of interactome networks: A practical tutorial

Anjo, S.I.; Martins-Marques, T.; Pereira, P.; Girão, H.; Manadas, B., 2018. Journal of Proteomics. 116 - 126. 171. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018674162&partnerID=MN8TOARS . 10.1016/j.jprot.2017.04.011 . Journal of Proteomics

Matrisome Profiling during Intervertebral Disc Development and Ageing

Caldeira, J.; Santa, C.; Osório, H.; Molinos, M.; Manadas, B.; Goncalves, R.; Barbosa, M., 2017. Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029508543&partnerID=MN8TOARS . 10.1038/s41598-017-11960-0 . Scientific Reports

Functional and structural characterization of synthetic cardosin B-derived rennet

Almeida, C.M.; Manso, J.A.; Figueiredo, A.C.; Antunes, L.; Cruz, R.; Manadas, B.; Bur, D.; et al, 2017. Applied Microbiology and Biotechnology. 6951 - 6968. 18. 101. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026776770&partnerID=MN8TOARS . 10.1007/s00253-017-8445-8 . Applied Microbiology and Biotechnology

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid

Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences

A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid's proteome

Trindade, F.; Bastos, P.; Leite-Moreira, A.; Manadas, B.; Ferreira, R.; Soares, S.F.; Daniel-da-Silva, A.L.; Falcão-Pires, I.; Vitorino, R., 2017. Archives of Biochemistry and Biophysics. 1 - 10. 634. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030090771&partnerID=MN8TOARS . 10.1016/j.abb.2017.09.016 . Archives of Biochemistry and Biophysics

EDTA-functionalized magnetic nanoparticles: A suitable platform for the analysis of low abundance urinary proteins

Bastos, P.; Trindade, F.; Ferreira, R.; Leite-Moreira, A.; Falcão-Pires, I.; Manadas, B.; Daniel-da-Silva, A.L.; Vitorino, R., 2017. Talanta. 81 - 88. 170. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016933823&partnerID=MN8TOARS . 10.1016/j.talanta.2017.03.087 . Talanta

A proteomic and ultrastructural characterization of Aspergillus fumigatus' conidia adaptation at different culture ages

Anjo, S.I.; Figueiredo, F.; Fernandes, R.; Manadas, B.; Oliveira, M., 2017. Journal of Proteomics. 47 - 56. 161. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017103862&partnerID=MN8TOARS . 10.1016/j.jprot.2017.03.021 . Journal of Proteomics

SWATH-MS as a tool for biomarker discovery: From basic research to clinical applications

Anjo, S.I.; Santa, C.; Manadas, B., 2017. Proteomics. 3-4. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012914613&partnerID=MN8TOARS . 10.1002/pmic.201600278 . Proteomics

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

Leal, A.R.; Cruz, R.; Bur, D.; Huesgen, P.F.; Faro, R.; Manadas, B.; Wlodawer, A.; Faro, C.; Simoes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962833456&partnerID=MN8TOARS . 10.1038/srep23869 . Scientific Reports

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Rosa, N.; Marques, J.; Esteves, E.; Fernandes, M.; Mendes, V.M.; Afonso, A.; Dias, S.; et al, 2016. Biopreservation and Biobanking. 289 - 297. 4. 14. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981350223&partnerID=MN8TOARS . 10.1089/bio.2015.0054 . Biopreservation and Biobanking

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

Pires, A.O.; Mendes-Pinheiro, B.; Teixeira, F.G.; Anjo, S.I.; Ribeiro-Samy, S.; Gomes, E.D.; Serra, S.C.; et al, 2016. Stem Cells and Development. 1073 - 1083. 14. 25. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978401618&partnerID=MN8TOARS . 10.1089/scd.2016.0048 . Stem Cells and Development

A reference library of peripheral blood mononuclear cells for SWATH-MS analysis

Silva, C.; Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics - Clinical Applications. 760 - 764. 7. 10. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979075975&partnerID=MN8TOARS . 10.1002/prca.201600070 . Proteomics - Clinical Applications

Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation

Teixeira, F.G.; Panchalingam, K.M.; Assunção-Silva, R.; Serra, S.C.; Mendes-Pinheiro, B.; Patrício, P.; Jung, S.; et al, 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974718908&partnerID=MN8TOARS . 10.1038/srep27791 . Scientific Reports

Direct analysis of [6,6-<sup>2</sup>H<inf>2</inf>]glucose and [U-<sup>13</sup>C<inf>6</inf>]glucose dry blood spot enrichments by LC-MS/MS

Coelho, M.; Mendes, V.M.; Lima, I.S.; Martins, F.O.; Fernandes, A.B.; Macedo, M.P.; Jones, J.G.; Manadas, B., 2016. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963956082&partnerID=MN8TOARS . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Protein precipitation of diluted samples in SDS-containing buffer with acetone leads to higher protein recovery and reproducibility in comparison with TCA/acetone approach

Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971222028&partnerID=MN8TOARS . 10.1002/pmic.201600024 . Proteomics

Bioaccessibility and changes on cylindrospermopsin concentration in edible mussels with storage and processing time

Freitas, M.; Azevedo, J.; Carvalho, A.P.; Mendes, V.M.; Manadas, B.; Campos, A.; Vasconcelos, V.; et al, 2016. Food Control. 567 - 574. 59. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934975039&partnerID=MN8TOARS . 10.1016/j.foodcont.2015.06.025 . Food Control

Bursaphelenchus xylophilus and B. mucronatus secretomes: A comparative proteomic analysis

Cardoso, J.M.S.; Anjo, S.I.; Fonseca, L.; Egas, C.; Manadas, B.; Abrantes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006073833&partnerID=MN8TOARS . 10.1038/srep39007 . Scientific Reports

Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028)

Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2016. Biochimie. 336 - 336. 121. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957818600&partnerID=MN8TOARS . 10.1016/j.biochi.2015.11.025 . Biochimie

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?

Travassos M; Santana I; Baldeiras I; Tsolaki M; Gkatzima O; Sermin G; Yener GG; et al, 2015. 2015. http://europepmc.org/abstract/med/26401784 . 10.3233/JAD-150374 .

Gap junctional protein Cx&lt;inf&gt;43&lt;/inf&gt; is involved in the communication between extracellular vesicles and mammalian cells

Soares, A.R.; Martins-Marques, T.; Ribeiro-Rodrigues, T.; Ferreira, J.V.; Catarino, S.; Pinho, M.J.; Zuzarte, M.; et al, 2015. Scientific Reports. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939865125&partnerID=MN8TOARS . 10.1038/srep13243 . Scientific Reports

Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of Wharton Jelly mesenchymal stem cell secretome?

Teixeira FG; Panchalingam KM; Anjo SI; Manadas B; Pereira R; Sousa N; Salgado AJ; et al, 2015. Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec. 2015. http://europepmc.org/abstract/med/26204925 . 10.1186/s13287-015-0124-z . Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec

Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.

Soares AR; Martins-Marques T; Ribeiro-Rodrigues T; Ferreira JV; Catarino S; Pinho MJ; Zuzarte M; et al, 2015. 2015. http://europepmc.org/abstract/med/26445927 . 10.1038/srep14888 .

Reduced a-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

Schneeberger, M.; Gómez-Valadés, A.G.; Altirriba, J.; Sebastián, D.; Ramírez, S.; Garcia, A.; Esteban, Y.; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937518875&partnerID=MN8TOARS . 10.1016/j.celrep.2015.06.041 . Cell Reports

Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics

Coelho, M.; Nunes, P.; Mendes, V.M.; Manadas, B.; Heerschap, A.; Jones, J.G., 2015. Journal of Diabetes Research. 2015. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937692377&partnerID=MN8TOARS . 10.1155/2015/542029 . Journal of Diabetes Research

Short GeLC-SWATH: A fast and reliable quantitative approach for proteomic screenings

Anjo, S.I.; Santa, C.; Manadas, B., 2015. Proteomics. 757 - 762. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922847099&partnerID=MN8TOARS . 10.1002/pmic.201400221 . Proteomics

Interacting network of the gap junction protein connexin43 is modulated by ischemia and reperfusion in the heart.

Martins-Marques T; Anjo SI; Pereira P; Manadas B; Girao H; Martins-Marques, T.; Anjo, S.I.; et al, 2015. Molecular and Cellular Proteomics. 3040 - 3055. 11. 14. 2015. http://europepmc.org/abstract/med/26316108 . 10.1074/mcp.M115.052894 . Molecular and Cellular Proteomics

Ser119 phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor

Soares-Dos-Reis, R.; Pessoa, A.S.; Matos, M.R.; Falcão, M.; Mendes, V.M.; Manadas, B.; Monteiro, F.A.; Lima, D.; Reguenga, C., 2014. Biochemical Journal. 441 - 453. 3. 459. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898656809&partnerID=MN8TOARS . 10.1042/BJ20131014 . Biochemical Journal

Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations

Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2013. Biochimie. 2297 - 2303. 12. 95. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887824472&partnerID=MN8TOARS . 10.1016/j.biochi.2013.06.028 . Biochimie

Comparative analysis of the exoproteomes of listeria monocytogenes strains grown at low temperatures

Cabrita, P.; Batista, S.; Machado, H.; Moes, S.; Jenö, P.; Manadas, B.; Trigo, M.J.; et al, 2013. Foodborne Pathogens and Disease. 428 - 434. 5. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879104474&partnerID=MN8TOARS . 10.1089/fpd.2012.1385 . Foodborne Pathogens and Disease

Toward a standardized saliva proteome analysis methodology

Vitorino, R.; Guedes, S.; Manadas, B.; Ferreira, R.; Amado, F., 2012. Journal of Proteomics. 5140 - 5165. 17. 75. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865548707&partnerID=MN8TOARS . 10.1016/j.jprot.2012.05.045 . Journal of Proteomics

Comparative proteomic analysis of auxin-induced embryogenic and nonembryogenic tissues of the solanaceous tree c yphomandra betacea (tamarillo)

Correia, S.; Vinhas, R.; Manadas, B.; Lourenço, A.S.; Veríssimo, P.; Canhoto, J.M., 2012. Journal of Proteome Research. 1666 - 1675. 3. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857806173&partnerID=MN8TOARS . 10.1021/pr200856w . Journal of Proteome Research

Partitioning the proteome: Phase separation for targeted analysis of membrane proteins in human post-mortem brain

English, J.A.; Manadas, B.; Scaife, C.; Cotter, D.R.; Dunn, M.J., 2012. PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862702997&partnerID=MN8TOARS . 10.1371/journal.pone.0039509 . PLoS ONE

Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides

Vinhas, R.; Cortes, L.; Cardoso, I.; Mendes, V.M.; Manadas, B.; Todo-Bom, A.; Pires, E.; Veríssimo, P., 2011. Allergy: European Journal of Allergy and Clinical Immunology. 1088 - 1098. 8. 66. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960015037&partnerID=MN8TOARS . 10.1111/j.1398-9995.2011.02598.x . Allergy: European Journal of Allergy and Clinical Immunology

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water

Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052079316&partnerID=MN8TOARS . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Peptide fractionation in proteomics approaches

Manadas, B.; Mendes, V.M.; English, J.; Dunn, M.J., 2010. Expert Review of Proteomics. 655 - 663. 5. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958550083&partnerID=MN8TOARS . 10.1586/epr.10.46 . Expert Review of Proteomics

BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: Protein levels and dendritic mRNA

Manadas, B.; Santos, A.R.; Szabadfi, K.; Gomes, J.R.; Garbis, S.D.; Fountoulakis, M.; Duarte, C.B., 2009. Journal of Proteome Research. 4536 - 4552. 10. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349976976&partnerID=MN8TOARS . 10.1021/pr900366x . Journal of Proteome Research

Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction

Manadas, B.; English, J.A.; Wynne, K.J.; Cotter, D.R.; Dunn, M.J., 2009. Proteomics. 5194 - 5198. 22. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70949086044&partnerID=MN8TOARS . 10.1002/pmic.200900349 . Proteomics

Critical roles for a genetic code alteration in the evolution of the genus Candida

Silva, R.M.; Paredes, J.A.; Moura, G.R.; Manadas, B.; Lima-Costa, T.; Rocha, R.; Miranda, I.; et al, 2007. EMBO Journal. 4555 - 4565. 21. 26. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648984625&partnerID=MN8TOARS . 10.1038/sj.emboj.7601876 . EMBO Journal

Sample sonication after trichloroacetic acid precipitation increases protein recovery from cultured hippocampal neurons, and improves resolution and reproducibility in two-dimensional gel electrophoresis

Manadas, B.J.; Vougas, K.; Fountoulakis, M.; Duarte, C.B.; Manadas, Bruno J.; Vougas, Konstantinos; Fountoulakis, Michael; Duarte, Carlos B., 2006. Electrophoresis. 1825 - 1831. 9. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646590654&partnerID=MN8TOARS . 10.1002/elps.200500757 . Electrophoresis

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

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