Publicações
Informação sobre artigos em revista, actualizada a 30-11-2025, a partir da plataforma CIÊNCIAVITAE.
Targeting NRF2 with Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders
Silva, Ana Cristina Rosa da, Oxidative Medicine and Cellular Longevity. 2025. accepted Oxidative Medicine and Cellular Longevity
Overcoming challenges in the development of cosmetic formulations with agro-industrial by-products: The case of cork powder
Mota, Sandra; Torres, Ana; Silva, Paulo; Silva, Joana Rocha e; Almeida, Agostinho; Páscoa, Ricardo N. M. J.; Ferreira, Helena N.; et al, International Journal of Cosmetic Science. 2025. https://doi.org/10.1111/ics.13066 . 10.1111/ics.13066 . published International Journal of Cosmetic Science
Protective effects of irbesartan against neurodegeneration in APP/PS1 mice: Unraveling its triple anti-apoptotic, anti-inflammatory and anti-oxidant action
Gouveia, Filipa; Pérez, Marina Carrasco; Bicker, Joana; Silva, Ana Cristina Rosa da; Santos, Armanda E.; Pereira, Cláudia Fragão; Camins, Antoni; et al, Biomedicine & Pharmacotherapy. 188. 2025. https://doi.org/10.1016/j.biopha.2025.118167 . 10.1016/j.biopha.2025.118167 . published Biomedicine & Pharmacotherapy
New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice
Rodrigues, Beatriz; Ventura, Eduarda; Moreira, Patrícia; Resende, Rosa; Bicker, Joana; Santos, Armanda E.; Pereira, Cláudia Fragão; et al, Neurobiology of Aging. 105 - 123. 147. 2025. https://doi.org/10.1016/j.neurobiolaging.2024.12.005 . 10.1016/j.neurobiolaging.2024.12.005 . published Neurobiology of Aging
Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging
Ana Silva; Cláudia Pinto; Sara M. Cravo; Sandra Mota; Liliana Rego; Smeera Ratanji; Clara Quintas; et al, Pharmaceuticals. 2025. https://www.mdpi.com/1424-8247/18/1/121 . 10.3390/ph18010121 . published Pharmaceuticals
Cork powder: Benefits and limitations as a sustainable cosmetic ingredient
Mota, Sandra; Torres, Ana; Silva, Ana Cristina Rosa da; Silva, José Paulo; Rocha e Silva, Joana; Ferreira, Helena Neto; Cruz, Maria T.; de Almeida, Isabel Martins, Powder Technology. 449. 2025. https://doi.org/10.1016/j.powtec.2024.120396 . 10.1016/j.powtec.2024.120396 . published Powder Technology
Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease
Moreira, Patrícia; Macedo, Jéssica; Matos, Patrícia; Bicker, Joana; Fortuna, Ana; Figueirinha, Artur; Salgueiro, Lígia; et al, Biomedicine & Pharmacotherapy. 181. 2024. https://doi.org/10.1016/j.biopha.2024.117652 . 10.1016/j.biopha.2024.117652 . published Biomedicine & Pharmacotherapy
Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel
Brites, Gonçalo S.; Ferreira, Isabel; Sebastião, Ana I.; Sousa, Cátia; Silva, Ana Cristina Rosa da; Carrascal, Mylene; Oliveira, Rui C.; et al, Journal of Pharmaceutical Analysis. 2024. https://doi.org/10.1016/j.jpha.2024.101071 . 10.1016/j.jpha.2024.101071 . published Journal of Pharmaceutical Analysis
Road traffic noise exposure and its impact on health: evidence from animal and human studies—chronic stress, inflammation, and oxidative stress as key components of the complex downstream pathway underlying noise-induced non-auditory health effects
Arregi, Ane; Vegas, Oscar; Lertxundi, Aitana; Silva, Ana Cristina Rosa da; Ferreira, Isabel; Bereziartua, Ainhoa; Cruz, Maria Teresa; Lertxundi, Nerea, Environmental Science and Pollution Research. 46820 - 46839. 34. 31. 2024. https://doi.org/10.1007/s11356-024-33973-9 . 10.1007/s11356-024-33973-9 . published Environmental Science and Pollution Research
Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model
Gouveia, Filipa; Fonseca, Carla; Silva, Ana Cristina Rosa da; Camins, Antoni; Teresa Cruz, M.; Ettcheto, Miren; Fortuna, Ana, International Immunopharmacology. 128. 2024. http://dx.doi.org/10.1016/j.intimp.2023.111471 . 10.1016/j.intimp.2023.111471 . published International Immunopharmacology
Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities of Santolina rosmarinifolia L. Essential Oil from Portugal
Alves-Silva, Jorge M.; Gonçalves, Maria José; Silva, Ana Cristina Rosa da; Cavaleiro, Carlos; Cruz, Maria Teresa; Salgueiro, Lígia, Antibiotics. 1. 12. 2023. http://dx.doi.org/10.3390/antibiotics12010179 . 10.3390/antibiotics12010179 . Antibiotics
Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil
Alves-Silva, Jorge M.; Cocco, Emma; Piras, Alessandra; Gonçalves, Maria José; Silva, Ana Cristina Rosa da; Falconieri, Danilo; Porcedda, Silvia; et al, Plants. 2. 12. 2023. http://dx.doi.org/10.3390/plants12020359 . 10.3390/plants12020359 . Plants
Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
Ferreira, Isabel; Brites, Gonçalo; Silva, Ana Cristina Rosa da; Caramelo, Francisco; Oliveiros, Bárbara; Neves, Bruno Miguel; Cruz, Maria Teresa, Archives of Toxicology. 2441 - 2451. 9. 97. 2023. http://dx.doi.org/10.1007/s00204-023-03550-z . 10.1007/s00204-023-03550-z . published Archives of Toxicology
Protective role of Portuguese natural mineral waters on skin aging: in vitro evaluation of anti-senescence and anti-oxidant properties
Vaz, CV; Oliveira, AS; Silva, Ana Cristina Rosa da; Cortes, L; Correia, S; Ferreira, R; Breitenfeld, L; et al, International Journal of Biometeorology. 2117 - 2131. 10. 66. 2022. http://dx.doi.org/10.1007/s00484-022-02345-8 . 10.1007/s00484-022-02345-8 . published International Journal of Biometeorology
Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes
Conte, Fernanda Lopes; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, Patrícia; et al, Phytomedicine Plus. 2. 2. 2022. http://dx.doi.org/10.1016/j.phyplu.2022.100231 . 10.1016/j.phyplu.2022.100231 . published Phytomedicine Plus
Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy)
Piras, Alessandra; Maccioni, Alfredo; Falconieri, Danilo; Porcedda, Silvia; Gonçalves, Maria José; Alves-Silva, Jorge M.; Silva, Ana; et al, Natural Product Research. 1 - 8. 2021. http://dx.doi.org/10.1080/14786419.2021.2018432 . 10.1080/14786419.2021.2018432 . published Natural Product Research
Therapies for Alzheimer’s disease: a metabolic perspective
Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana, Molecular Genetics and Metabolism. 2021. http://dx.doi.org/10.1016/j.ymgme.2021.01.011 . 10.1016/j.ymgme.2021.01.011 . published Molecular Genetics and Metabolism
Giardia lamblia Decreases NF-¿B p65RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages
Faria, Clarissa Perez; Neves, Bruno Miguel; Lourenço, Ágata; Cruz, Maria Teresa; Martins, João D.; Silva, Ana; Pereira, Sónia; Sousa, Maria do Céu, Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-63231-0 . 10.1038/s41598-020-63231-0 . Scientific Reports
Anti-inflammatory potential of Portuguese thermal waters
Silva, Ana Cristina Rosa da; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al, Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-79394-9 . 10.1038/s41598-020-79394-9 . published Scientific Reports
Evaluating skin sensitization via soft and hard multivariate modelling
Filipa A L S Silva; Gonçalo Brites; Isabel Ferreira; Silva, Ana Cristina Rosa da; Bruno Miguel Neves; Jorge L G F S Costa Pereira; Maria Teresa Cruz; et al, International Journal of Toxicology. 2020. http://dx.doi.org/10.1177/1091581820944395 . 10.1177/1091581820944395 . published International Journal of Toxicology
In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions
Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; Martinez-de-Oliveira, José; et al, International Journal of Biometeorology. 2020. http://dx.doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . International Journal of Biometeorology
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
Sebastião, Ana Isabel; Ferreira, Isabel; Brites, Gonçalo; Silva, Ana Cristina Rosa da; Neves, Bruno Miguel; Teresa Cruz, Maria, Pharmaceutics. 9. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12090867 . 10.3390/pharmaceutics12090867 . published Pharmaceutics
Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-¿B Signaling Pathway
Catarino, Marcelo D.; Silva, Ana; Cruz, Maria T.; Mateus, Nuno; Silva, Artur M.S.; Cardoso, Susana M., International Journal of Molecular Sciences. 18. 21. 2020. http://dx.doi.org/10.3390/ijms21186897 . 10.3390/ijms21186897 . International Journal of Molecular Sciences
Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models
Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al, International Journal of Molecular Sciences. 20. 21. 2020. http://dx.doi.org/10.3390/ijms21207791 . 10.3390/ijms21207791 . published International Journal of Molecular Sciences
Allergic contact dermatitis: From pathophysiology to development of new preventive strategies
Brites, Gonçalo Sousa; Ferreira, Isabel; Sebastião, Ana Isabel; Silva, Ana; Carrascal, Mylene; Neves, Bruno Miguel; Cruz, Maria T., Pharmacological Research. 162. 2020. http://dx.doi.org/10.1016/j.phrs.2020.105282 . 10.1016/j.phrs.2020.105282 . published Pharmacological Research
Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens
Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, Environmental Geochemistry and Health. 2019. http://dx.doi.org/10.1007/s10653-019-00473-6 . 10.1007/s10653-019-00473-6 . Environmental Geochemistry and Health
Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1
Ferreira, Isabel; Silva, Ana; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa, Redox Biology. 75 - 86. 16. 2018. http://dx.doi.org/10.1016/j.redox.2018.02.002 . 10.1016/j.redox.2018.02.002 . Redox Biology
Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease
Silva, A.C.; Ferreira, I.L.; Hayden, M.R.; Ferreiro, E.; Rego, A.C., Biochimica et Biophysica Acta - Molecular Basis of Disease. 34 - 44. 1. 1864. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031746642&partnerID=MN8TOARS . 10.1016/j.bbadis.2017.09.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation
Almeida Paiva, Rafael; Martins-Marques, Tania; Jesus, Katia; Ribeiro-Rodrigues, Teresa; Zuzarte, Monica; Silva, Ana; Reis, Liliana; et al, Journal of Cellular and Molecular Medicine. 1137 - 1151. 2. 23. 2018. http://dx.doi.org/10.1111/jcmm.14014 . 10.1111/jcmm.14014 . Journal of Cellular and Molecular Medicine
Inflammasome in dendritic cells immunobiology: Implications to diseases and therapeutic strategies
Ferreira, I.; Liberal, J.; Martins, J.D.; Silva, A.; Neves, B.M.; Cruz, M.T., Current Drug Targets. 1003 - 1018. 9. 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022193483&partnerID=MN8TOARS . 10.2174/1389450117666160921144830 . Current Drug Targets
Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene
Martins, J.D.; Silva, A.; Ferreira, I.; Gonçalo, M.; Custódio, J.B.A.; Lopes, M.C.; Domingues, M.R.M.; Neves, B.M.; Cruz, M.T., Toxicology Research. 1512 - 1521. 6. 5. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993965439&partnerID=MN8TOARS . 10.1039/c6tx00240d . Toxicology Research
Phospholipidomic Profile Variation on THP-1 Cells Exposed to Skin or Respiratory Sensitizers and Respiratory Irritant
Martins, J.D.; Maciel, E.A.; Silva, A.; Ferreira, I.; Ricardo, F.; Domingues, P.; Neves, B.M.; Domingues, M.R.M.; Cruz, M.T., Journal of Cellular Physiology. 2639 - 2651. 12. 231. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983242587&partnerID=MN8TOARS . 10.1002/jcp.25365 . Journal of Cellular Physiology
Autophagy and inflammasome interplay
Martins, J.D.; Liberal, J.; Silva, A.; Ferreira, I.; Neves, B.M.; Cruz, M.T., DNA and Cell Biology. 274 - 281. 4. 34. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926611400&partnerID=MN8TOARS . 10.1089/dna.2014.2752 . DNA and Cell Biology
Systemic drugs inducing non-immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells
Gonçalo, M.; Martins, J.; Silva, A.; Neves, B.; Figueiredo, A.; Cruz, T.; Lopes, C., Journal of Applied Toxicology. 398 - 406. 4. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923069689&partnerID=MN8TOARS . 10.1002/jat.3033 . Journal of Applied Toxicology
Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease
Silva, Ana Cristina Rosa da; Naia, L.; Dominguez, A.; Ribeiro, M.; Rodrigues, J.; Vieira, O.V.; Lessmann, V.; Rego, A.C., Neurodegenerative Diseases. 207 - 218. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939565482&partnerID=MN8TOARS . 10.1159/000375447 . published Neurodegenerative Diseases
Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells
Silva, Ana Cristina Rosa da; Nunes, C.; Martins, J.; Dinis, T.C.P.; Lopes, C.; Neves, B.; Cruz, T., Free Radical Biology and Medicine. 238 - 246. 72. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901040063&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2014.04.005 . Free Radical Biology and Medicine
Oxidative stress-dependent activation of the eIF2a–ATFr unfolded protein response branch by skin sensitizer 1-fluoro-2,4-dinitrobenzene modulates dendritic-like cell maturation and inflammatory status in a biphasic manner
Luís, Andreia; Martins, João Demétrio; Silva, Ana Cristina Rosa da; Ferreira, Isabel; Cruz, Maria Teresa; Neves, Bruno Miguel, Free Radical Biology and Medicine. 217 - 229. 77. 2014. https://doi.org/10.1016/j.freeradbiomed.2014.09.008 . 10.1016/j.freeradbiomed.2014.09.008 . published Free Radical Biology and Medicine
Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic huntington's disease carriers
Silva, A.C.; Almeida, S.; Laço, M.; Duarte, A.I.; Domingues, J.; Oliveira, C.R.; Januário, C.; Rego, A.C., Mitochondrion. 801 - 809. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887018742&partnerID=MN8TOARS . 10.1016/j.mito.2013.05.006 . Mitochondrion
Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells-protective effect oflcystamine and creatine
Ribeiro, M.; Silva, A.C.; Rodrigues, J.; Naia, L.; Rego, A.C., Toxicological Sciences. 487 - 499. 2. 136. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890357270&partnerID=MN8TOARS . 10.1093/toxsci/kft199 . Toxicological Sciences
Development of an in vitro dendritic cell-based test for skin sensitizer identification
Neves, B.M.; Rosa, S.C.; Martins, J.D.; Silva, A.; Goncìalo, M.; Lopes, M.C.; Cruz, M.T., Chemical Research in Toxicology. 368 - 378. 3. 26. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875168719&partnerID=MN8TOARS . 10.1021/tx300472d . Chemical Research in Toxicology
BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype
Silva, Ana Cristina Rosa da; Pereira, Jorge; Oliveira, Catarina R.; Relvas, João Bettencourt; Rego, A. Cristina, Journal of Neuroscience Research. 1986 - 1996. 9. 87. 2009. http://dx.doi.org/10.1002/jnr.22041 . 10.1002/jnr.22041 . published Journal of Neuroscience Research
5 41 de 41 Publicações
Todos os projectos
Informação da exclusiva responsabilidade do investigador 30-11-2025 , a partir da plataforma CIÊNCIAVITAE.
2023/10 - 2024/09
ChemSensing - A biosensor to detect human skin sensitizers
PEP II0363
Principal investigator
Universidade de Coimbra
Financiadores: Society of Toxicology (SOT); Colgate Palmolive Co
2023/05 - 2024/01
Deciphering the key events of micro- and nanoplastics toxicity triggered in skin to establish the adverse outcome pathway (AOP)
-
Other
Financiadores: Laboratoires Vichy
2023/03 - 2025/03
The effect of LUSO natural mineral water intake on urolithiasis – focus on gut and urinary tract microbiota-associated inflammation
PSE-2022-105
Principal investigator
Universidade de Coimbra
Financiadores: Sociedade Central de Cervejas
2022/05 - 2023/02
In Vitro evaluation of the toxicity, sensitizing potential and biological action of cork powder and respective extracts
PSE 2020-020
Research Fellow
Universidade do Porto
2018/09 - 2022/01/31
Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease
CENTRO-01-0145-FEDER-029369
Researcher
Financiadores: Fundação para a Ciência e a Tecnologia
2017/06 - 2018/09
Study of the therapeutic properties of thermal waters - dermocosmetic
CENTRO-04-3928-FEDER-000010
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Faculdade de Farmácia
2016 - 2020
Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer)
.
Other
Toxfinder Lda; Universidade de Coimbra
Financiadores: Cosmetics Europe
2014 - 2015
Exosomes: putative biomarkers for respiratory and cutaneous allergens hazard
PRIME-XS 262067
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
2014 - 2015
In chemico, in silico and in vitro modeling to predict human respiratory allergens
CAAT Project #2014-07
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Financiadores: Johns Hopkins University Center for Alternatives to Animal Testing
2014/05 - 2015/06
ToxVitroTesting
QREN nº.38977
Post-doc Fellow
Toxfinder Lda
2012/04/01 - 2013
In vitro alternative approach for chemical skin sensitization hazard: an EU legislation demand
PTDC/SAL-OSM/099762/2008
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2011 - 2012
BDNF medeia protecção e diferenciação neuronal na doença de Huntington
PEI-HDCR01
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Financiadores: Universidade de Coimbra Faculdade de Medicina
2010 - 2012
Analysis of transcription deregulation in brain and peripheral Huntington’s disease models – influence of modulating histone deacetylases
PTDC/SAU-FCF/108056/2008
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2006 - 2007
Mitochondrial-dependent cell death control through transcription regulation in the presence of FK506 and BDNF – protective role in Huntington’s disease
POCI/SAU-NEU/57310/2004
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Financiadores: Fundação para a Ciência e a Tecnologia
2003 - 2004
Serra de Monfurado. Conservação e valorização do Património Natural - Fauna
N/A
Research Technician Fellow
Universidade de Évora
Financiadores: Comissão de Coordenação e Desenvolvimento Regional do Alentejo
5 15 de 15 projetos
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