Metabolismo, Envelhecimento e Doença

Mitocôndria, Metabolismo e Doença

Mitocôndria

Metabolismo

Toxicologia

Terapias Mitocondriais

Envelhecimento

Farmacologia

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Líder

Paulo J. Oliveira

Investigador(a)


Linhas de interesse

Papel da remodelação mitocondrial no envelhecimento e doenças associadas ao estilo de vida

Toxicologia mitocondrial de fármacos e poluentes ambientais

Terapêuticas dirigidas à mitocôndria e proteção mitocondrial

Visão Geral

A mitocôndria é um organelo crítico no contexto da fisiologia celular. Funciona como central energética da célula, produzindo a maioria da energia química, desempenhando ainda papeis muito importantes na regulação da morte e controlo de qualidade celulares. Por serem participantes ativos na homeostasia redox e no controlo do cálcio celular, o nosso grupo tenta fornecer avanços significativos no conhecimento das alterações mitocondriais contextualizadas no metabolismo, sinalização redox e respostas de stress em toxicidade química, cancro, doenças cardiovasculares e hepáticas, envelhecimento e diferenciação de células estaminais.

O nosso foco é determinar se a regulação intrínseca, farmacológica ou não farmacológica (exemplo: mediada pelo exercício físico) da biogénese, metabolismo e controlo de qualidade mitocondrial é capaz de reduzir a lesão do órgão durante diferentes patologias ou causada pela toxicidade de xenobióticos. Mecanismos de biogénese mitocondrial e sua regulação por moléculas como o resveratrol ou proteínas como sirtuinas têm sido importantes questões experimentais. Outro objetivo importante, é investigar de que forma a actividade mitocondrial regula a diferenciação de células estaminais (cancerígenas).

Diferentes moléculas ou patologias activam vias de toxicidade/stress mitocondriais, afetando o fenótipo celular e frequentemente a sobrevivência do órgão. Entre os diferentes tóxicos mitocondriais, destacamos agentes cancerígenos como antraciclinas, anti-estrogénios ou retinoides. Desenvolvemos uma biblioteca de moléculas dirigidas à mitocôndria que poderão ser promissores agentes anti-cancerígenos ou antioxidantes.
Considerando as alterações mitocondriais durante o processo de envelhecimento, investigamos o papel da disfunção bioenergética mitocondrial e do desarranjo da beta-oxidação de ácidos gordos na mitocôndria e peroxisomas na menopausa associada ao decaimento de estrogénios.

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Pinho, Sónia A.; Costa, Cláudio F.; Deus, Cláudia M.; Pinho, Sonia L.C.; Miranda-Santos, Inês; Afonso, Gonçalo; Bagshaw, Olivia; et al, 2022. The FEBS Journal. 2022. http://dx.doi.org/10.1111/febs.16413 . 10.1111/febs.16413 . published The FEBS Journal

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Paulo J Oliveira, 2022. European Heart Journal. 2022. https://doi.org/10.1093/eurheartj/ehab399 . 10.1093/eurheartj/ehab399 . European Heart Journal

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Anabela Marisa Azul; Martin Winter; Daniel Silva; Liljana Georgievska; Paulo J. Oliveira, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13749 . 10.1111/eci.13749 . European Journal of Clinical Investigation

The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to Therapeutics

Catarina Melim; Maria R. Lauro; Isabel M. Pires; Paulo J. Oliveira; Célia Cabral, 2022. Pharmaceutics. 2022. https://doi.org/10.3390/pharmaceutics14010190 . 10.3390/pharmaceutics14010190 . Pharmaceutics

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, João A.; Coppotelli, Giuseppe; Rolo, Anabela P.; Palmeira, Carlos M.; Ross, Jaime M.; Sinclair, David A., 2022. Nature Reviews Endocrinology. 2022. http://dx.doi.org/10.1038/s41574-021-00626-7 . 10.1038/s41574-021-00626-7 . Nature Reviews Endocrinology

Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant Molecule on Bovine Sperm Function and Embryo Production

João Campos Santos; Carla Cruz Marques; Maria Conceição Baptista; Jorge Pimenta; José Carlos Santos Teixeira; Liliana Montezinho; Fernando Cagide; et al, 2022. Animals. 2022. https://www.mdpi.com/2076-2615/12/7/804 . 10.3390/ani12070804 . Animals

Mitochondrial and metabolic remodelling in human skin fibroblasts in response to glucose availability

Sónia A. Pinho; Cláudio F. Costa; Cláudia M. Deus; Sonia L. C. Pinho; Inês Miranda-Santos; Gonçalo Afonso; Olivia Bagshaw; et al, 2022. The FEBS Journal. 2022. https://doi.org/10.1111/febs.16413 . 10.1111/febs.16413 . The FEBS Journal

Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage

Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simões, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Inês; et al, 2022. Free Radical Biology and Medicine. 119 - 132. 179. 2022. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304 . 10.1016/j.freeradbiomed.2021.12.304 . Free Radical Biology and Medicine

Cytoskeleton alterations in non-alcoholic fatty liver disease

Pessoa, João; Teixeira, José, 2022. Metabolism. 128. 2022. http://dx.doi.org/10.1016/j.metabol.2021.155115 . 10.1016/j.metabol.2021.155115 . Metabolism

Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics

Rui F. Simões; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2022. International Journal of Molecular Sciences. 3009 - 3009. 6. 23. 2022. https://doi.org/10.3390/ijms23063009 . 10.3390/ijms23063009 . International Journal of Molecular Sciences

The Use of a Single, Novel Preservation Solution in Split Liver Transplantation and Hypothermic Oxygenated Machine Perfusion

2022. Transplantation. e187 - e188. 3. 106. 2022. published Transplantation

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira, 2022. Cells. 688 - 688. 4. 11. 2022. https://doi.org/10.3390/cells11040688 . 10.3390/cells11040688 . Cells

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints

Cunha-Oliveira, T.; Carvalho, Marcelo; Sardão, V.; Ferreiro, Elisabete; Mena, D.; Francisco B Pereira ; Borges, Fernanda; Oliveira, P.J.; Silva, Filomena, 2022. Research Square. 2022. https://www.researchsquare.com/article/rs-1196454/v1 . 10.21203/rs.3.rs-1196454/v1 . under revision Research Square

Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics

Rui F. Simões; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2022. International Journal of Molecular Sciences. 3009 - 3009. 6. 23. 2022. https://doi.org/10.3390/ijms23063009 . 10.3390/ijms23063009 . International Journal of Molecular Sciences

PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury

Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira, 2022. International Journal of Molecular Sciences. 1156 - 1156. 3. 23. 2022. https://doi.org/10.3390/ijms23031156 . 10.3390/ijms23031156 . International Journal of Molecular Sciences

IGL-2 as a Unique Solution for Cold Static Preservation and Machine Perfusion in Liver and Mitochondrial Protection

Rui Teixeira Da Silva; Raquel G. Bardallo; Emma Folch-Puy; Teresa Carbonell; Carlos M. Palmeira; Constantino Fondevila; René Adam; Joan Roselló-Catafau; Arnau Panisello-Roselló, 2022. Transplantation Proceedings. 73 - 76. 1. 54. 2022. https://doi.org/10.1016/j.transproceed.2021.10.008 . 10.1016/j.transproceed.2021.10.008 . Transplantation Proceedings

Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

Rui F. Simões; Rute Pino; Maurício Moreira-Soares; Jaromira Kovarova; Jiri Neuzil; Rui Travasso; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2021. The FASEB Journal. 12. 35. 2021. https://doi.org/10.1096/fj.202100899R . 10.1096/fj.202100899R . The FASEB Journal

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Carlos Fernandes; Afonso J. C. Videira; Caroline D. Veloso; Sofia Benfeito; Pedro Soares; João D. Martins; Beatriz Gonçalves; et al, 2021. Biomolecules. 1605 - 1605. 11. 11. 2021. https://doi.org/10.3390/biom11111605 . 10.3390/biom11111605 . Biomolecules

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Luís F. Grilo; Carolina Tocantins; Mariana S. Diniz; Rodrigo Mello Gomes; Paulo J. Oliveira; Paulo Matafome; Susana P. Pereira, 2021. European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13625 . 10.1111/eci.13625 . European Journal of Clinical Investigation

Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation

Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. Ageing Research Reviews. 67. 2021. http://dx.doi.org/10.1016/j.arr.2021.101309 . 10.1016/j.arr.2021.101309 . Ageing Research Reviews

Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics

Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; R. Fernandes; Teodoro, J.S.; Patrícia Matos; et al, 2021. Nutrients. 2021. https://www.mdpi.com/2072-6643/13/12/4192 . 10.3390/nu13124192 . Nutrients

Identification of a novel mutation in MEF2C gene in an atypical patient with Frontotemporal Lobar Degeneration

Grazina, Manuela, 2021. Neurological Sciences. 2021. in press Neurological Sciences

miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia

Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. International Journal of Molecular Sciences. 2. 22. 2021. http://dx.doi.org/10.3390/ijms22020541 . 10.3390/ijms22020541 . International Journal of Molecular Sciences

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Fernandes, Carlos; Videira, Afonso J. C.; Veloso, Caroline D.; Benfeito, Sofia; Soares, Pedro; Martins, João D.; Gonçalves, Beatriz; et al, 2021. Biomolecules. 11. 11. 2021. http://dx.doi.org/10.3390/biom11111605 . 10.3390/biom11111605 . Biomolecules

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Daniel Chavarria; Ophelie DA SILVA; Sofia Benfeito; Sandra Barreiro; Jorge Garrido; Cagide-Fagín; Pedro Soares; et al, 2021. Antioxidants. 2021. https://www.mdpi.com/2076-3921/10/2/329 . 10.3390/antiox10020329 . Antioxidants

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, 2021. Redox Biology. 45. 2021. http://dx.doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . Redox Biology

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Amorim, Ricardo; Simões, Inês C. M.; Veloso, Caroline; Carvalho, Adriana; Simões, Rui F.; Pereira, Francisco B.; Thiel, Theresa; et al, 2021. Nutrients. 5. 13. 2021. http://dx.doi.org/10.3390/nu13051723 . 10.3390/nu13051723 . Nutrients

Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts

Teixeira, José; Basit, Farhan; Willems, Peter H.G.M.; Wagenaars, Jori A.; van de Westerlo, Els; Amorim, Ricardo; Cagide, Fernando; et al, 2021. Free Radical Biology and Medicine. 314 - 324. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.023 . 10.1016/j.freeradbiomed.2020.12.023 . Free Radical Biology and Medicine

The potential role of sestrin 2 in liver regeneration

Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. Free Radical Biology and Medicine. 255 - 267. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027 . 10.1016/j.freeradbiomed.2020.12.027 . Free Radical Biology and Medicine

MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile

Jacinto, Sandra; Guerreiro, Patrícia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria João; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago F., 2021. Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.641264 . 10.3389/fncel.2021.641264 . published Frontiers in Cellular Neuroscience

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Simões, Inês C. M.; Amorim, Ricardo; Teixeira, José; Karkucinska-Wieckowska, Agnieszka; Carvalho, Adriana; Pereira, Susana P.; Simões, Rui F.; et al, 2021. International Journal of Molecular Sciences. 13. 22. 2021. http://dx.doi.org/10.3390/ijms22136848 . 10.3390/ijms22136848 . International Journal of Molecular Sciences

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; et al, 2021. Redox Biology. 102037 - 102037. 45. 2021. https://doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . Redox Biology

Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown

Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. International Journal of Molecular Sciences. 21. 22. 2021. http://dx.doi.org/10.3390/ijms222111738 . 10.3390/ijms222111738 . International Journal of Molecular Sciences

Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

Rui F. Simões; Rute Pino; Maurício Moreira-Soares; Jaromira Kovarova; Jiri Neuzil; Rui Travasso; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, 2021. The FASEB Journal. 12. 35. 2021. https://doi.org/10.1096/fj.202100899R . 10.1096/fj.202100899R . The FASEB Journal

Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation

Henrique J. Cardoso; Marília I. Figueira; Cátia V. Vaz; Tiago M. A. Carvalho; Luís A. Brás; Patrícia A. Madureira; Paulo J. Oliveira; Vilma A. Sardão; Sílvia Socorro, 2021. Cellular Oncology. 2021. https://doi.org/10.1007/s13402-020-00575-9 . 10.1007/s13402-020-00575-9 . Cellular Oncology

H9c2(2-1)-based sulforhodamine B assay as a possible alternative in vitro platform to investigate effluent and metals toxicity on fish

Elsa T. Rodrigues; Miguel A. Pardal; Eduarda Pereira; Joana F. Monteiro; Ana C. Certal; Paulo J. Oliveira, 2021. Chemosphere. 2021. https://doi.org/10.1016/j.chemosphere.2021.130009 . 10.1016/j.chemosphere.2021.130009 . Chemosphere

Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 Cardiomyoblasts

Bruno M. Moukette; José P. Castelão-Baptista; Luciana Ferreira; Ana M. Silva; Rui F. Simões; Célia Cabral; Constant A. Pieme; et al, 2021. Evidence-Based Complementary and Alternative Medicine. 2021. https://doi.org/10.1155/2021/8858165 . 10.1155/2021/8858165 . Evidence-Based Complementary and Alternative Medicine

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, 2021. Redox Biology. 2021. http://dx.doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . published Redox Biology

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Pereira, Susana P.; Tavares, Ludgero C.; Duarte, Ana I.; Baldeiras, Inês; Cunha-Oliveira, Teresa; Martins, João D.; Santos, Maria S.; et al, 2021. Clinical Science. 1103 - 1126. 9. 135. 2021. http://dx.doi.org/10.1042/cs20201339 . 10.1042/cs20201339 . published Clinical Science

Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Costa, C. F.; Pinho, S.A.; Pinho, S. L.; Miranda-Santos, I.; Bagshaw, O.; Stuart, J.; Oliveira, P.J.; # Cunha-Oliveira, T., 2021. BioRxiv. 2021. https://www.biorxiv.org/content/10.1101/2021.02.24.432508v1 . 10.1101/2021.02.24.432508 . published BioRxiv

MPV17 mutations are associated with a quiescent energetic metabolic profile

Jacinto, Sandra; Guerreiro. Patrícia; Machado de Oliveira, Rita; Cunha-Oliveira, T.; Santos, Maria João; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago, 2021. Frontiers in Cellular Neuroscience. 2021. https://www.frontiersin.org/articles/10.3389/fncel.2021.641264/abstract . published Frontiers in Cellular Neuroscience

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Simões, Rui F.; Ferrão, Rafaela; Silva, Margarida R.; Pinho, Sonia L. C.; Ferreira, Lino; Oliveira, Paulo J.; # Cunha-Oliveira, T., 2021. Food and Chemical Toxicology. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . published Food and Chemical Toxicology

Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity

Serafim, Teresa L.; * Cunha-Oliveira, Teresa; Deus, Claudia M.; Sardão, Vilma A.; Cardoso, Ines M.; Yang, Shanshan; Odhiambo, John F.; et al, 2020. European Journal of Clinical Investigation. 2. 51. 2020. http://dx.doi.org/10.1111/eci.13375 . 10.1111/eci.13375 . published European Journal of Clinical Investigation

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Cunha-Oliveira, Teresa; Montezinho, Liliana; Mendes, Catarina; Firuzi, Omidreza; Saso, Luciano; Oliveira, Paulo J.; Silva, Filomena S. G., 2020. Oxidative Medicine and Cellular Longevity. 1 - 29. 2020. 2020. http://dx.doi.org/10.1155/2020/5021694 . 10.1155/2020/5021694 . published Oxidative Medicine and Cellular Longevity

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M., 2020. International Journal of Molecular Sciences. 14. 21. 2020. http://dx.doi.org/10.3390/ijms21144896 . 10.3390/ijms21144896 . International Journal of Molecular Sciences

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

Ines C. M. Simoes; Agnieszka Karkucinska-Wieckowska; Justyna Janikiewicz; Sylwia Szymanska; Maciej Pronicki; Pawel Dobrzyn; Michal Dabrowski; et al, 2020. Antioxidants. 995 - 995. 10. 9. 2020. https://doi.org/10.3390/antiox9100995 . 10.3390/antiox9100995 . Antioxidants

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats

Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; et al, 2020. Pharmaceutics. 11. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12111094 . 10.3390/pharmaceutics12111094 . Pharmaceutics

Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes

João S. Teodoro; Rui Silva; António Aguiar; Abílio J. F. N. Sobral; Anabela P. Rolo; Carlos M. Palmeira, 2020. Toxicology Mechanisms and Methods. 536 - 545. 7. 30. 2020. https://doi.org/10.1080/15376516.2020.1780361 . 10.1080/15376516.2020.1780361 . Toxicology Mechanisms and Methods

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy

Kendall B. Wallace; Vilma A. Sardão; Paulo J. Oliveira, 2020. Circulation Research. 926 - 941. 7. 126. 2020. https://doi.org/10.1161/CIRCRESAHA.119.314681 . 10.1161/CIRCRESAHA.119.314681 . Circulation Research

Doxorubicin persistently rewires cardiac circadian homeostasis in mice

Luciana L. Ferreira; Marlene Cervantes; Hugo J. C. Froufe; Conceição Egas; Teresa Cunha-Oliveira; Paolo Sassone-Corsi; Paulo J. Oliveira, 2020. Archives of Toxicology. 257 - 271. 1. 94. 2020. https://doi.org/10.1007/s00204-019-02626-z . 10.1007/s00204-019-02626-z . Archives of Toxicology

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Guida Bento; Aygul K. Shafigullina; Albert A. Rizvanov; Vilma A. Sardão; Maria Paula Macedo; Paulo J. Oliveira, 2020. Cells. 573 - 573. 3. 9. 2020. https://doi.org/10.3390/cells9030573 . 10.3390/cells9030573 . Cells

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Teresa Cunha-Oliveira; Liliana Montezinho; Catarina Mendes; Omidreza Firuzi; Luciano Saso; Paulo J. Oliveira; Filomena S. G. Silva; Jos L. Quiles, 2020. Oxidative Medicine and Cellular Longevity. 2020. https://doi.org/10.1155/2020/5021694 . 10.1155/2020/5021694 . Oxidative Medicine and Cellular Longevity

Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection

Ana R. Coelho; Paulo J. Oliveira, 2020. European Journal of Clinical Investigation. 2020. https://doi.org/10.1111/eci.13366 . 10.1111/eci.13366 . European Journal of Clinical Investigation

Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

Susana Ponte; Lara Carvalho; Maria Gagliardi; Isabel Campos; Paulo J. Oliveira; António Jacinto, 2020. Biology Open. 2020. https://doi.org/10.1242/bio.048629 . 10.1242/bio.048629 . Biology Open

MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal

Silva, Filipe; Ferreira, Filipa; Faria, Pedro; Sobral, Isa; Rodrigues, Mariana; Pratas, João; Silva, João Filipe; et al, 2020. Acta Médica Portuguesa. 13. 34. 2020. http://dx.doi.org/10.20344/amp.14922 . 10.20344/amp.14922 . published Acta Médica Portuguesa

Altered mitochondrial metabolism in the insulin-resistant heart

Makrecka-Kuka, M.; Liepinsh, E.; Murray, A.J.; Lemieux, H.; Dambrova, M.; Tepp, K.; Puurand, M.; et al, 2020. Acta Physiologica. 3. 228. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077842678&partnerID=MN8TOARS . 10.1111/apha.13430 . Acta Physiologica

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H<inf>2</inf>O<inf>2</inf>-Dependent Mechanism

Almeida, N.; Carrara, G.; Palmeira, C.M.; Fernandes, A.S.; Parsons, M.; Smith, G.L.; Saraiva, N., 2020. Redox Biology. 28. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074222003&partnerID=MN8TOARS . 10.1016/j.redox.2019.101361 . Redox Biology

Publicly stressing the role of mitochondria in NAFLD with(in) a sports event

Mireia Alemany-Pagès; Rui Tavares; Sara Varela Amaral; Ana Teresa Barros-Viegas; Paulo J. Oliveira; João Ramalho-Santos; Anabela Marisa Azul, 2020. European Journal of Clinical Investigation. 2020. https://doi.org/10.1111/eci.13234 . 10.1111/eci.13234 . European Journal of Clinical Investigation

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

Gomes, P.; Viana, S.D.; Nunes, S.; Rolo, A.P.; Palmeira, C.M.; Reis, F., 2020. Ageing Research Reviews. 57. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076952156&partnerID=MN8TOARS . 10.1016/j.arr.2019.100983 . Ageing Research Reviews

Therapeutic options targeting oxidative stress, mitochondrial dysfunction and inflammation to hinder the progression of vascular complications of diabetes

Teodoro, J.S.; Nunes, S.; Rolo, A.P.; Reis, F.; Palmeira, C.M., 2019. Frontiers in Physiology. JAN. 10. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065463466&partnerID=MN8TOARS . 10.3389/fphys.2018.01857 . Frontiers in Physiology

Evaluation of bioenergetic and mitochondrial function in liver transplantation

Martins, R.M.; Teodoro, J.S.; Furtado, E.; Rolo, A.P.; Palmeira, C.M.; Tralhão, J.G., 2019. Clinical and Molecular Hepatology. 190 - 198. 2. 25. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068517981&partnerID=MN8TOARS . 10.3350/cmh.2018.0087 . Clinical and Molecular Hepatology

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins

Palmeira, C.M.; Teodoro, J.S.; Amorim, J.A.; Steegborn, C.; Sinclair, D.A.; Rolo, A.P., 2019. Free Radical Biology and Medicine. 483 - 491. 141. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069629808&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2019.07.017 . Free Radical Biology and Medicine

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues

Daniel Chavarria; Carlos Fernandes; Brandon Aguiar; Tiago Silva; Jorge Garrido; Fernando Remiao; Paulo J. Oliveira; Eugenio Uriarte; Borges Fernanda, 2019. Molecules. 2019. https://www.mdpi.com/1420-3049/24/23/4405 . 10.3390/molecules24234405 . Molecules

Correspondence

Alexandrino, H.; Palmeira, C., 2019. British Journal of Surgery. 152 - 152. 1. 106. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058912518&partnerID=MN8TOARS . 10.1002/bjs.11055 . British Journal of Surgery

Evaluation of bioenergetic and mitochondrial function in liver transplantation

Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José Guilherme, 2019. Clinical and Molecular Hepatology. 190 - 198. 2. 25. 2019. http://dx.doi.org/10.3350/cmh.2018.0087 . 10.3350/cmh.2018.0087 . Clinical and Molecular Hepatology

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

Daniel Chavarria; Carlos Fernandes; Tiago Silva; Jorge Garrido; Fernando Remião; Paulo J. Oliveira; Fernanda Borges, 2019. Organic & Biomolecular Chemistry. 2019. https://doi.org/10.1039/C9OB01875A . 10.1039/C9OB01875A . Organic & Biomolecular Chemistry

Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans

Rodrigues-Soares, Fernanda; Peñas-Lledó, Eva M.; Tarazona-Santos, Eduardo; Sosa-Macías, Martha; Terán, Enrique; López-López, Marisol; Rodeiro, Idania; et al, 2019. Clinical Pharmacology & Therapeutics. 257 - 268. 1. 107. 2019. http://dx.doi.org/10.1002/cpt.1598 . 10.1002/cpt.1598 . published Clinical Pharmacology & Therapeutics

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Adriana Fontes; Mireia Alemany-Pagès; Paulo J. Oliveira; João Ramalho-Santos; Hans Zischka; Anabela Marisa Azul, 2019. International Journal of Molecular Sciences. 3987 - 3987. 16. 20. 2019. https://doi.org/10.3390/ijms20163987 . 10.3390/ijms20163987 . International Journal of Molecular Sciences

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

Luciana L. Ferreira; Teresa Cunha-Oliveira; Caroline D. Veloso; Cláudio F. Costa; Kendall B. Wallace; Paulo J. Oliveira, 2019. Food and Chemical Toxicology. 450 - 461. 124. 2019. https://doi.org/10.1016/j.fct.2018.12.017 . 10.1016/j.fct.2018.12.017 . Food and Chemical Toxicology

A Mitochondrial Approach to Cardiovascular Risk and Disease

Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís Filipe Fragoso Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, 2019. Current Protein & Peptide Science. 2019. https://doi.org/10.2174/1389203720666190830163735 . 10.2174/1389203720666190830163735 . Current Protein & Peptide Science

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Ignazio Grattagliano; Liliana P. Montezinho; Paulo J. Oliveira; Gema Frühbeck; Javier Gómez-Ambrosi; Fabrizio Montecucco; Federico Carbone; et al, 2019. Biochemical Pharmacology. 34 - 45. 160. 2019. https://doi.org/10.1016/j.bcp.2018.11.020 . 10.1016/j.bcp.2018.11.020 . Biochemical Pharmacology

miR-378a: a new emerging microRNA in metabolism

Machado, I.F.; Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P., 2019. Cellular and Molecular Life Sciences. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075434955&partnerID=MN8TOARS . 10.1007/s00018-019-03375-z . Cellular and Molecular Life Sciences

Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation—An experimental study

Martins, R.M.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Rolo, A.P.; Palmeira, C.M., 2019. International Journal of Medical Sciences. 1304 - 1312. 9. 16. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072941379&partnerID=MN8TOARS . 10.7150/ijms.34617 . International Journal of Medical Sciences

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A<inf>2A</inf> receptor over-activation in a rat model of Parkinson's disease

Carmo, M.; Gonçalves, F.Q.; Canas, P.M.; Oses, J.-P.; Fernandes, F.D.; Duarte, F.V.; Palmeira, C.M.; et al, 2019. British Journal of Pharmacology. 3666 - 3680. 18. 176. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070072977&partnerID=MN8TOARS . 10.1111/bph.14771 . British Journal of Pharmacology

Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides

Elsa T. Rodrigues; Ana T. Varela; Miguel A. Pardal; Paulo J. Oliveira, 2019. Environmental Pollution. 476 - 482. 252. 2019. https://doi.org/10.1016/j.envpol.2019.05.033 . 10.1016/j.envpol.2019.05.033 . Environmental Pollution

Doxorubicin persistently rewires cardiac circadian homeostasis in mice

Ferreira, Luciana L.; Cervantes, Marlene; Froufe, Hugo J. C.; Egas, Conceição; Cunha-Oliveira, Teresa; Sassone-Corsi, Paolo; Oliveira, Paulo J., 2019. Archives of Toxicology. 2019. http://dx.doi.org/10.1007/s00204-019-02626-z . 10.1007/s00204-019-02626-z . published Archives of Toxicology

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress

Ferreira, Leonardo M. R.; Cunha-Oliveira, Teresa; Sobral, Margarida C.; Abreu, Patrícia L.; Alpoim, Maria Carmen; Urbano, Ana M., 2019. International Journal of Molecular Sciences. 19. 20. 2019. http://dx.doi.org/10.3390/ijms20194901 . 10.3390/ijms20194901 . published International Journal of Molecular Sciences

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

Ferreira, Luciana L.; Cunha-Oliveira, Teresa; Veloso, Caroline D.; Costa, Cláudio F.; Wallace, Kendall B.; Oliveira, Paulo J., 2019. Food and Chemical Toxicology. 450 - 461. 124. 2019. http://dx.doi.org/10.1016/j.fct.2018.12.017 . 10.1016/j.fct.2018.12.017 . published Food and Chemical Toxicology

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Belew, Getachew Debas; Silva, Joao; Rito, Joao; Tavares, Ludgero; Viegas, Ivan; Teixeira, Jose; Oliveira, Paulo J.; Macedo, Maria Paula; Jones, John G., 2019. Journal of Lipid Research. 2050 - 2056. 12. 60. 2019. http://dx.doi.org/10.1194/jlr.ra119000354 . 10.1194/jlr.ra119000354 . published Journal of Lipid Research

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents

Oliveira, Catarina; Bagetta, Donatella; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Silva, Tiago; Garrido, Jorge; et al, 2019. European Journal of Medicinal Chemistry. 116 - 129. 174. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.04.026 . 10.1016/j.ejmech.2019.04.026 . published European Journal of Medicinal Chemistry

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction

Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al, 2019. European Journal of Medicinal Chemistry. 525 - 545. 167. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.01.055 . 10.1016/j.ejmech.2019.01.055 . published European Journal of Medicinal Chemistry

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease

Valdinocci, Dario; Simões, Rui F.; Kovarova, Jaromira; Cunha-Oliveira, Teresa; Neuzil, Jiri; Pountney, Dean L., 2019. Frontiers in Neuroscience. 13. 2019. http://dx.doi.org/10.3389/fnins.2019.00930 . 10.3389/fnins.2019.00930 . Frontiers in Neuroscience

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; et al, 2019. Cell Metabolism. 399 - 416.e10. 2. 29. 2019. http://dx.doi.org/10.1016/j.cmet.2018.10.014 . 10.1016/j.cmet.2018.10.014 . published Cell Metabolism

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells

Abreu, Patrícia L.; Cunha-Oliveira, Teresa; Ferreira, Leonardo M. R.; Urbano, Ana M., 2018. BioMetals. 477 - 487. 4. 31. 2018. http://dx.doi.org/10.1007/s10534-018-0093-7 . 10.1007/s10534-018-0093-7 . published BioMetals

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity

Pereira, Susana P; Deus, Cláudia M; Serafim, Teresa L; Cunha-Oliveira, Teresa; Oliveira, Paulo J, 2018. Toxicological Sciences. 191 - 204. 1. 164. 2018. http://dx.doi.org/10.1093/toxsci/kfy068 . 10.1093/toxsci/kfy068 . published Toxicological Sciences

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

Reis, Joana; Cagide, Fernando; Valencia, Martín Estrada; Teixeira, José; Bagetta, Donatella; Pérez, Concepción; Uriarte, Eugenio; et al, 2018. European Journal of Medicinal Chemistry. 781 - 800. 158. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.07.056 . 10.1016/j.ejmech.2018.07.056 . published European Journal of Medicinal Chemistry

Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity

Ribeiro, José A.; Benfeito, Sofia; Cagide, Fernando; Teixeira, José; Oliveira, Paulo J.; Borges, Fernanda; Silva, António F.; Pereira, Carlos M., 2018. Analytical Chemistry. 7989 - 7996. 13. 90. 2018. http://dx.doi.org/10.1021/acs.analchem.8b00787 . 10.1021/acs.analchem.8b00787 . published Analytical Chemistry

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors

Oliveira, Catarina; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Sequeira, Lisa; Mesiti, Francesco; Silva, Tiago; et al, 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00126 . 10.3389/fchem.2018.00126 . published Frontiers in Chemistry

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

José Teixeira; Catarina Oliveira; Fernando Cagide; Ricardo Amorim; Jorge Garrido; Fernanda Borges; Paulo J. Oliveira, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 567 - 576. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1442831 . 10.1080/14756366.2018.1442831 . Journal of Enzyme Inhibition and Medicinal Chemistry

TRAP1 regulates autophagy in lung cancer cells.

Barbosa IA; Vega-Naredo I; Loureiro R; Branco AF; Garcia R; Scott PM; Oliveira PJ, 2018. European journal of clinical investigation. 2018. http://europepmc.org/abstract/med/29383696 . 10.1111/eci.12900 . European journal of clinical investigation

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Panisello-Roselló, A.; Lopez, A.; Folch-Puy, E.; Carbonell, T.; Rolo, A.; Palmeira, C.; Adam, R.; Net, M.; Roselló-Catafau, J., 2018. World Journal of Gastroenterology. 2984 - 2994. 27. 24. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050972436&partnerID=MN8TOARS . 10.3748/wjg.v24.i27.2984 . World Journal of Gastroenterology

Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant

Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al, 2018. Neuromuscular Disorders. 350 - 360. 4. 28. 2018. http://dx.doi.org/10.1016/j.nmd.2017.11.006 . 10.1016/j.nmd.2017.11.006 . Neuromuscular Disorders

Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics

Naranjo, María-Eugenia G.; Rodrigues-Soares, Fernanda; Peñas-Lledó, Eva M.; Tarazona-Santos, Eduardo; Fariñas, Humberto; Rodeiro, Idania; Terán, Enrique; et al, 2018. OMICS: A Journal of Integrative Biology. 575 - 588. 9. 22. 2018. http://dx.doi.org/10.1089/omi.2018.0114 . 10.1089/omi.2018.0114 . OMICS: A Journal of Integrative Biology

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.

Marques-Aleixo I; Santos-Alves E; Oliveira PJ; Moreira PI; Magalhães J; Ascensão A, 2018. Biochimica et biophysica acta. Reviews on cancer. 2018. http://europepmc.org/abstract/med/29408395 . 10.1016/j.bbcan.2018.01.002 . Biochimica et biophysica acta. Reviews on cancer

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes

# Teresa Cunha-Oliveira; Luciana L. Ferreira; Ana Raquel Coelho; Cláudia M. Deus; Paulo J. Oliveira, 2018. Toxicology and Applied Pharmacology. 1 - 13. 348. 2018. https://doi.org/10.1016/j.taap.2018.04.009 . 10.1016/j.taap.2018.04.009 . published Toxicology and Applied Pharmacology

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al, 2018. Magnetic Resonance in Medicine. 639 - 644. 1. 81. 2018. http://dx.doi.org/10.1002/mrm.27378 . 10.1002/mrm.27378 . published Magnetic Resonance in Medicine

Research update for articles published in EJCI in 2016

Adlbrecht, C.; Blanco-Verea, A.; Bouzas-Mosquera, M.C.; Brion, M.; Burtscher, M.; Carbone, F.; Chang, T.-T.; et al, 2018. European Journal of Clinical Investigation. 10. 48. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053529293&partnerID=MN8TOARS . 10.1111/eci.13016 . European Journal of Clinical Investigation

Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity

Pereira, L.C.; Cabral Miranda, L.F.; Franco-Bernardes, M.F.; Tasso, M.J.; Duarte, F.V.; Inácio Varela, A.T.; Rolo, A.P.; Marques Palmeira, C.M.; Dorta, D.J., 2018. Chemico-Biological Interactions. 192 - 201. 291. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049064624&partnerID=MN8TOARS . 10.1016/j.cbi.2018.06.021 . Chemico-Biological Interactions

Recent insights into mitochondrial targeting strategies in liver transplantation

Martins, R.M.; Teodoro, J.S.; Furtado, E.; Rolo, A.P.; Palmeira, C.M.; Tralhão, J.G., 2018. International Journal of Medical Sciences. 248 - 256. 3. 15. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045188539&partnerID=MN8TOARS . 10.7150/ijms.22891 . International Journal of Medical Sciences

Cytoprotective mechanisms in fatty liver preservation against cold ischemia injury: A comparison between IGL-1 and HTK

Panisello-Roselló, A.; Verde, E.; Lopez, A.; Flores, M.; Folch-Puy, E.; Rolo, A.; Palmeira, C.; et al, 2018. International Journal of Molecular Sciences. 2. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041019515&partnerID=MN8TOARS . 10.3390/ijms19020348 . International Journal of Molecular Sciences

Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, 2018. Redox Biology. 694 - 696. 14. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS . 10.1016/j.redox.2017.10.001 . Redox Biology

Addition of berberine to preservation solution in an animal model of ex vivo liver transplant preserves mitochondrial function and bioenergetics from the damage induced by ischemia/reperfusion

Martins, R.M.; Rolo, A.P.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Palmeira, C.M., 2018. International Journal of Molecular Sciences. 1. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040938454&partnerID=MN8TOARS . 10.3390/ijms19010284 . International Journal of Molecular Sciences

Indirubin and NAD<sup>+</sup> prevent mitochondrial ischaemia/reperfusion damage in fatty livers

Teodoro, J.S.; Varela, A.T.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P., 2018. European Journal of Clinical Investigation. 6. 48. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045238716&partnerID=MN8TOARS . 10.1111/eci.12932 . European Journal of Clinical Investigation

CYP2D6 Pharmacogenetics Testing and Post–Cesarean Section Pain Scores—a Preliminary Study

Ribeiro, Carolina; Quinta, Rosa; Raposo, Ana; Valentim, Ana; Albuquerque, José; Grazina, Manuela, 2018. Pain Medicine. 359 - 368. 2. 20. 2018. http://dx.doi.org/10.1093/pm/pny033 . 10.1093/pm/pny033 . Pain Medicine

SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application.

Correia-da-Silva M; Rocha V; Marques C; Deus CM; Marques-Carvalho A; Oliveira PJ; Palmeira A; et al, 2018. Journal of molecular endocrinology. 2018. http://europepmc.org/abstract/med/29588426 . 10.1530/jme-18-0031 . Journal of molecular endocrinology

Aldehyde dehydrogenase 2 (ALDH2) in rat fatty liver cold ischemia injury

Panisello-Roselló, A.; Alva, N.; Flores, M.; Lopez, A.; Benítez, C.C.; Folch-Puy, E.; Rolo, A.; et al, 2018. International Journal of Molecular Sciences. 9. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052507134&partnerID=MN8TOARS . 10.3390/ijms19092479 . International Journal of Molecular Sciences

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants.

Teixeira J; Deus CM; Borges F; Oliveira PJ, 2018. The international journal of biochemistry & cell biology. 2018. http://europepmc.org/abstract/med/29454114 . 10.1016/j.biocel.2018.02.007 . The international journal of biochemistry & cell biology

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

Reis J; Cagide F; Valencia ME; Teixeira J; Bagetta D; Pérez C; Uriarte E; et al, 2018. European journal of medicinal chemistry. 2018. http://europepmc.org/abstract/med/30245401 . 10.1016/j.ejmech.2018.07.056 . European journal of medicinal chemistry

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M; Kovarova J; Coelho AR; Boukalova S; Oh S; Rohlenova K; Svec D; et al, 2018. Cell metabolism. 2018. http://europepmc.org/abstract/med/30449682 . 10.1016/j.cmet.2018.10.014 . Cell metabolism

Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells.

Silva AM; Oliveira PJ, 2018. Methods in molecular biology (Clifton, N.J.). 2018. http://europepmc.org/abstract/med/29850992 . 10.1007/978-1-4939-7831-1_2 . Methods in molecular biology (Clifton, N.J.)

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

José Teixeira; Catarina Oliveira; Fernando Cagide; Ricardo Amorim; Jorge Garrido; Fernanda Borges; Paulo J. Oliveira, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 567 - 576. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1442831 . 10.1080/14756366.2018.1442831 . published Journal of Enzyme Inhibition and Medicinal Chemistry

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

Teixeira, J.; Basit, F.; Swarts, H.G.; Forkink, M.; Oliveira, P.J.; Willems, P.H.G.M.; Koopman, W.J.H., 2018. Redox Biology. 394 - 404. 15. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040366459&partnerID=MN8TOARS . 10.1016/j.redox.2017.12.018 . published Redox Biology

Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity.

Ribeiro JA; Benfeito S; Cagide F; Teixeira J; Oliveira PJ; Borges F; Silva AF; Pereira CM, 2018. Analytical chemistry. 2018. http://europepmc.org/abstract/med/29863846 . 10.1021/acs.analchem.8b00787 . Analytical chemistry

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate.

Jarak I; Barosa C; Martins FO; Silva JCP; Santos C; Belew GD; Rito J; et al, 2018. Magnetic resonance in medicine. 2018. http://europepmc.org/abstract/med/30058123 . 10.1002/mrm.27378 . Magnetic resonance in medicine

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

Carlos Fernandes; Sofia Benfeito; Ricardo Amorim; José Teixeira; Paulo J. Oliveira; Fernando Remião; Fernanda Borges, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.8b00383 . 10.1021/acs.bioconjchem.8b00383 . Bioconjugate Chemistry

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Cunha-Oliveira T; Ferreira LL; Coelho AR; Deus CM; Oliveira PJ, 2018. Toxicology and applied pharmacology. 2018. http://europepmc.org/abstract/med/29653124 . 10.1016/j.taap.2018.04.009 . Toxicology and applied pharmacology

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative

Teixeira, J.; Amorim, R.; Santos, K.; Soares, P.; Datta, S.; Cortopassi, G.A.; Serafim, T.L.; et al, 2018. Toxicology. 123 - 139. 393. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034013034&partnerID=MN8TOARS . 10.1016/j.tox.2017.11.014 . published Toxicology

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

Giorgi C; Marchi S; Simoes ICM; Ren Z; Morciano G; Perrone M; Patalas-Krawczyk P; et al, 2018. International review of cell and molecular biology. 2018. http://europepmc.org/abstract/med/30072092 . 10.1016/bs.ircmb.2018.05.006 . International review of cell and molecular biology

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity.

Pereira SP; Deus CM; Serafim TL; Cunha-Oliveira T; Oliveira PJ, 2018. Toxicological sciences : an official journal of the Society of Toxicology. 2018. http://europepmc.org/abstract/med/29945227 . 10.1093/toxsci/kfy068 . Toxicological sciences : an official journal of the Society of Toxicology

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.

Fernandes C; Pinto M; Martins C; Gomes MJ; Sarmento B; Oliveira PJ; Remião F; Borges F, 2018. Bioconjugate chemistry. 2018. http://europepmc.org/abstract/med/29635917 . 10.1021/acs.bioconjchem.8b00151 . Bioconjugate chemistry

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

Carlos Fernandes; Sofia Benfeito; Ricardo Amorim; José Teixeira; Paulo J. Oliveira; Fernando Remião; Fernanda Borges, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.8b00383 . 10.1021/acs.bioconjchem.8b00383 . published Bioconjugate Chemistry

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

Teixeira, José; Deus, Cláudia M.; Borges, Fernanda; Oliveira, Paulo J., 2018. The International Journal of Biochemistry & Cell Biology. 98 - 103. 97. 2018. http://dx.doi.org/10.1016/j.biocel.2018.02.007 . 10.1016/j.biocel.2018.02.007 . published The International Journal of Biochemistry & Cell Biology

Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains

Filipa S. Carvalho; Catarina M. Morais; Jon Holy; Dmytro Krasutsky; Sergiy V. Yemets; Pavel A. Krasutsky; Amália S. Jurado; Paulo J. Oliveira; Teresa L. Serafim, 2018. Chemico-Biological Interactions. 198 - 210. 296. 2018. https://doi.org/10.1016/j.cbi.2018.10.002 . 10.1016/j.cbi.2018.10.002 . Chemico-Biological Interactions

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.

Oliveira C; Cagide F; Teixeira J; Amorim R; Sequeira L; Mesiti F; Silva T; et al, 2018. Frontiers in chemistry. 2018. http://europepmc.org/abstract/med/29740575 . 10.3389/fchem.2018.00126 . Frontiers in chemistry

Glutaminemia prognostic significance in critical surgical patients – An analysis of plasma aminogram profile; Significado pronóstico de la glutaminemia en pacientes quirúrgicos críticos - Análisis del perfil del aminograma plasmático

Costa, Beatriz Pinto; Martins, Paulo; Verissimo, Carla; Simões, Marta; Tomé, Marisa; Grazina, Manuela; Pimentel, Jorge; Sousa, Francisco Castro, 2017. Nutrición Hospitalaria. 4. 34. 2017. http://dx.doi.org/10.20960/nh.817 . 10.20960/nh.817 . published Nutrición Hospitalaria

Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling

Marques-Aleixo, I.; Santos-Alves, E.; Torrella, J. R.; Oliveira, P. J.; Magalhães, J.; Ascensão, A., 2017. Cardiovasc Toxicol. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28536949 . 10.1007/s12012-017-9412-4 . Cardiovasc Toxicol

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Teixeira, J.; Oliveira, C.; Amorim, R.; Cagide, F.; Garrido, J.; Ribeiro, J.A.; Pereira, C.M.; et al, 2017. Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026475854&partnerID=MN8TOARS . 10.1038/s41598-017-07272-y . published Scientific Reports

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease

Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A., 2017. Journal of Alzheimer's Disease. 525 - 536. 2. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

Bioenergetic adaptations of the human liver in the ALPPS procedure – how liver regeneration correlates with mitochondrial energy status

Alexandrino, H.; Rolo, A.; Teodoro, J.S.; Donato, H.; Martins, R.; Serôdio, M.; Martins, M.; et al, 2017. HPB. 1091 - 1103. 12. 19. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029605721&partnerID=MN8TOARS . 10.1016/j.hpb.2017.08.005 . HPB

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, 2017. Redox Biology. 94 - 162. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032301&partnerID=MN8TOARS . 10.1016/j.redox.2017.05.007 . Redox Biology

Lack of additive effects of resveratrol and energy restriction in the treatment of hepatic steatosis in rats

Milton-Laskibar, I.; Aguirre, L.; Fernández-Quintela, A.; Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M.; Portillo, M.P., 2017. Nutrients. 7. 9. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023760594&partnerID=MN8TOARS . 10.3390/nu9070737 . Nutrients

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease

Teixeira, J.; Chavarria, D.; Borges, F.; Wojtczak, L.; Wieckowski, M. R.; Karkucinska-Wieckowska, A.; Oliveira, P. J., 2017. Curr Med Chem. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28554320 . 10.2174/0929867324666170529101810 . Curr Med Chem

Genotyping CYP2D6 by three different methods: advantages and disadvantages

Ribeiro, Carolina; Martins, Patrícia; Grazina, Manuela, 2017. Drug Metabolism and Personalized Therapy. 1. 32. 2017. http://dx.doi.org/10.1515/dmpt-2016-0035 . 10.1515/dmpt-2016-0035 . published Drug Metabolism and Personalized Therapy

Mitochondrial biology in cancer stem cells.

Loureiro R; Mesquita KA; Magalhães-Novais S; Oliveira PJ; Vega-Naredo I, 2017. Seminars in cancer biology. 2017. http://europepmc.org/abstract/med/28673608 . 10.1016/j.semcancer.2017.06.012 . Seminars in cancer biology

In silico analysis for predicting pathogenicity of five unclassified mitochondrial DNA mutations associated with mitochondrial cytopathies' phenotypes

Bacalhau, Mafalda; Pratas, João; Simões, Marta; Mendes, Cândida; Ribeiro, Carolina; Santos, Maria J.; Diogo, Luísa; Macário, Maria Carmo; Grazina, Manuela, 2017. European Journal of Medical Genetics. 172 - 177. 3. 60. 2017. http://dx.doi.org/10.1016/j.ejmg.2016.12.009 . 10.1016/j.ejmg.2016.12.009 . published European Journal of Medical Genetics

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

Rossetti, A.; Togliatto, G.; Rolo, A.P.; Teodoro, J.S.; Granata, R.; Ghigo, E.; Columbano, A.; Palmeira, C.M.; Brizzi, M.F., 2017. Cell Death Discovery. 1. 3. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051289736&partnerID=MN8TOARS . 10.1038/cddiscovery.2017.77 . Cell Death Discovery

Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death

Pereira, L.C.; Souza, A.O.; Tasso, M.J.; Oliveira, A.M.C.; Duarte, F.V.; Palmeira, C.M.; Dorta, D.J., 2017. Journal of Toxicology and Environmental Health - Part A: Current Issues. 1129 - 1144. 19-21. 80. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033371791&partnerID=MN8TOARS . 10.1080/15287394.2017.1357370 . Journal of Toxicology and Environmental Health - Part A: Current Issues

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, André; * Cunha-Oliveira, Teresa; Simões, Rui F.; Carvalho, Filipa S.; Burgeiro, Ana; Nordgren, Kendra; Wallace, Kendall B.; Oliveira, Paulo J., 2017. Toxicology. 63 - 73. 390. 2017. http://dx.doi.org/10.1016/j.tox.2017.08.011 . 10.1016/j.tox.2017.08.011 . published Toxicology

mtDNA copy number associated with age of onset in familial amyloid polyneuropathy

Santos, Diana; Santos, Maria João; Alves-Ferreira, Miguel; Coelho, Teresa; Sequeiros, Jorge; Alonso, Isabel; Oliveira, Pedro; et al, 2017. Journal of Neurology, Neurosurgery & Psychiatry. 300 - 304. 3. 89. 2017. http://dx.doi.org/10.1136/jnnp-2017-316657 . 10.1136/jnnp-2017-316657 . Journal of Neurology, Neurosurgery & Psychiatry

Response to "In silico prediction is insufficient to assess pathogenicity of mtDNA variants".

Bacalhau, M.; Pratas, J.; Simões, M.; Mendes, C.; Ribeiro, C.; Santos, MJ; Diogo, L.; Macário, MC; Grazina, Manuela (1F10-D85D-B592), 2017. European journal of medical genetics. 2017. http://europepmc.org/abstract/med/28807868 . 10.1016/j.ejmg.2017.08.008 . European journal of medical genetics

Intestinal dysfunction in the critical trauma patients – An early and frequent event

Costa, Beatriz Pinto; Martins, Paulo; Verissimo, Carla; Simões, Marta; Tomé, Marisa; Grazina, Manuela; Pimentel, Jorge; Castro-Sousa, Francisco, 2017. Nutrición Hospitalaria. 2. 34. 2017. http://dx.doi.org/10.20960/nh.788 . 10.20960/nh.788 . published Nutrición Hospitalaria

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease

Teixeira, J.; Chavarria, D.; Borges, F.; Wojtczak, L.; Wieckowski, M. R.; Karkucinska-Wieckowska, A.; Oliveira, P. J., 2017. Curr Med Chem. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28554320 . 10.2174/0929867324666170529101810 . published Curr Med Chem

Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models

Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al, 2017. Journal of Medicinal Chemistry. 7084 - 7098. 16. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS . 10.1021/acs.jmedchem.7b00741 . published Journal of Medicinal Chemistry

Carvedilol and antioxidant proteins in a type I diabetes animal model

Diogo, Catia V.; Deus, Claudia M.; Lebiedzinska-Arciszewska, Magdalena; Wojtala, Aleksandra; Wieckowski, Mariusz R.; Oliveira, Paulo J., 2017. European Journal of Clinical Investigation. 19 - 29. 1. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393880700002&KeyUID=WOS:000393880700002 . 10.1111/eci.12696 . European Journal of Clinical Investigation

Exposure to BDE-153 induces autophagy in HepG2 cells.

Pereira LC; Duarte FV; Varela ATIF; Rolo AP; Palmeira CMM; Dorta DJ, 2017. 2017. http://europepmc.org/abstract/med/28396260 . 10.1016/j.tiv.2017.04.005 .

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.

Teixeira J; Basit F; Swarts HG; Forkink M; Oliveira PJ; Willems PHGM; Koopman WJH, 2017. Redox biology. 2017. http://europepmc.org/abstract/med/29331741 . 10.1016/j.redox.2017.12.018 . Redox biology

GSK3ß and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation.

Zaouali MA; Panisello A; Lopez A; Castro C; Folch E; Carbonell T; Rolo A; et al, 2017. 2017. http://europepmc.org/abstract/med/28282906 . 10.3390/ijms18030591 .

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.

Teixeira J; Amorim R; Santos K; Soares P; Datta S; Cortopassi GA; Serafim TL; et al, 2017. Toxicology. 2017. http://europepmc.org/abstract/med/29141199 . 10.1016/j.tox.2017.11.014 . Toxicology

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity.

Ferreira A; Cunha-Oliveira T; Simões RF; Carvalho FS; Burgeiro A; Nordgren K; Wallace KB; Oliveira PJ, 2017. Toxicology. 2017. http://europepmc.org/abstract/med/28865727 . 10.1016/j.tox.2017.08.011 . Toxicology

The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression.

Vecchione G; Grasselli E; Cioffi F; Baldini F; Oliveira PJ; Sardão VA; Cortese K; et al, 2017. Frontiers in nutrition. 2017. http://europepmc.org/abstract/med/28971098 . 10.3389/fnut.2017.00042 . Frontiers in nutrition

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts.

Coelho AR; Martins TR; Couto R; Deus C; Pereira CV; Simões RF; Rizvanov AA; et al, 2017. Biochimica et biophysica acta. Molecular basis of disease. 2017. http://europepmc.org/abstract/med/28760703 . 10.1016/j.bbadis.2017.07.030 . Biochimica et biophysica acta. Molecular basis of disease

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Teixeira, Jose; Oliveira, Catarina; Amorim, Ricardo; Cagide, Fernando; Garrido, Jorge; Ribeiro, Jose A.; Pereira, Carlos M.; et al, 2017. Scientific Reports. 7. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406610000093&KeyUID=WOS:000406610000093 . 10.1038/s41598-017-07272-y . Scientific Reports

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

Teixeira, Jose; Cagide, Fernando; Benfeito, Sofia; Soares, Pedro; Garrido, Jorge; Baldeiras, Ines; Ribeiro, Jose A.; et al, 2017. Journal of Medicinal Chemistry. 7084 - 7098. 16. 60. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408598500017&KeyUID=WOS:000408598500017 . 10.1021/acs.jmedchem.7b00741 . Journal of Medicinal Chemistry

An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity.

Pereira LC; Duarte FV; Varela AT; Rolo AP; Palmeira CM; Dorta DJ, 2017. 2017. http://europepmc.org/abstract/med/27234317 . 10.1016/j.tox.2016.05.022 .

The pathophysiological role of cholecystokinin-1 receptor in mouse cholelithogenesis

Carbone, Federico; Oliveira, Paulo J.; Bonaventura, Aldo; Montecucco, Fabrizio, 2017. European Journal of Clinical Investigation. 195 - 196. 2. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393880500011&KeyUID=WOS:000393880500011 . 10.1111/eci.12713 . European Journal of Clinical Investigation

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver

Duarte, F.V.; Amorim, J.A.; Varela, A.T.; Teodoro, J.S.; Gomes, A.P.; Cunha, R.A.; Palmeira, C.M.; et al, 2017. Purinergic Signalling. 179 - 190. 2. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995486129&partnerID=MN8TOARS . 10.1007/s11302-016-9548-x . Purinergic Signalling

Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients

Lassed, Somia; Deus, Claudia M.; Djebbari, Radja; Zama, Djamila; Oliveira, Paulo J.; Rizvanov, Albert A.; Dahdouh, Abderrezak; Benayache, Fadila; Benayache, Samir, 2017. Evidence-Based Complementary and Alternative Medicine. 91568 - 91568. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392530400001&KeyUID=WOS:000392530400001 . 10.1155/2017/1691568 . Evidence-Based Complementary and Alternative Medicine

Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells

Deus, C. M.; Serafim, T. L.; Magalhães-Novais, S.; Vilaça, A.; Moreira, A. C.; Sardão, V. A.; Cardoso, S. M.; Oliveira, P. J., 2017. Arch Toxicol. 1261 - 1278. 3. 91. 2017. https://www.ncbi.nlm.nih.gov/pubmed/27358235 . 10.1007/s00204-016-1784-x . Arch Toxicol

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

Gouveia, P. J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H. V.; Monteiro, L.; Nunes, J.; et al, 2017. Biomaterials. 213 - 228. 139. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Dong, L. F.; Kovarova, J.; Bajzikova, M.; Bezawork-Geleta, A.; Svec, D.; Endaya, B.; Sachaphibulkij, K.; et al, 2017. Elife. 6. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28195532 . 10.7554/eLife.22187 . Elife

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Naia, Luana; * Cunha-Oliveira, Teresa; Rodrigues, Joana; Rosenstock, Tatiana R.; Oliveira, Ana; Ribeiro, Márcio; Carmo, Catarina; et al, 2017. The Journal of Neuroscience. 2776 - 2794. 10. 37. 2017. http://dx.doi.org/10.1523/jneurosci.2006-14.2016 . 10.1523/JNEUROSCI.2006-14.2016 . published The Journal of Neuroscience

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts

Coelho, Ana R.; Martins, Tatiana R.; Couto, Renata; Deus, Cláudia; Pereira, Cláudia V.; Simões, Rui F.; Rizvanov, Albert A.; et al, 2017. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2904 - 2923. 11. 1863. 2017. http://dx.doi.org/10.1016/j.bbadis.2017.07.030 . 10.1016/j.bbadis.2017.07.030 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Association of p.Val158Met COMT polymorphism with paranoid ideation in drug addicts

Ribeiro, Carolina; Curto, João; Areias, Graça; Belo, Adriana; Balhau, João; Rocha Almeida, José; Grazina, Manuela, 2017. International Journal of Clinical Neurosciences and Mental Health. 4(Suppl. 3. 2017. http://dx.doi.org/10.21035/ijcnmh.2017.4(suppl.3).s12 . 10.21035/ijcnmh.2017.4(suppl.3).s12 . published International Journal of Clinical Neurosciences and Mental Health

Evaluation of biological properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity

Kochel, Krzysztof; Tomczyk, Mateusz D.; Simoes, Rui F.; Fraczek, Tomasz; Sobon, Adrian; Oliveira, Paulo J.; Walczak, Krzysztof Z.; et al, 2017. Bioorganic & Medicinal Chemistry Letters. 427 - 431. 3. 27. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392900600010&KeyUID=WOS:000392900600010 . 10.1016/j.bmc1.2016.12.055 . Bioorganic & Medicinal Chemistry Letters

Mitochondrial bioenergetics and posthepatectomy liver dysfunction.

Alexandrino H; Varela AT; Teodoro JS; Martins MA; Rolo AP; Tralhão JG; Palmeira CM; Castro E Sousa F, 2016. 2016. http://europepmc.org/abstract/med/27138992 . 10.1111/eci.12639 .

Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats.

Teodoro JS; Silva R; Varela AT; Duarte FV; Rolo AP; Hussain S; Palmeira CM, 2016. 2016. http://europepmc.org/abstract/med/27171910 . 10.2217/nnm-2016-0049 .

The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity.

Teodoro JS; Rolo AP; Jarak I; Palmeira CM; Carvalho RA, 2016. 2016. http://europepmc.org/abstract/med/27488269 . 10.1002/nbm.3583 .

Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, 2016. 2016. http://europepmc.org/abstract/med/27790925 . 10.1080/15376516.2016.1222643 .

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, Ana Marta; Barbosa, Inês A.; Seabra, Cátia; Beltrão, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; # Cunha-Oliveira, Teresa, 2016. Food and Chemical Toxicology. 148 - 158. 1. 94. 2016. http://dx.doi.org/10.1016/j.fct.2016.06.001 . 10.1016/j.fct.2016.06.001 . published Food and Chemical Toxicology

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population

Céspedes-Garro, Carolina; Rodrigues-Soares, Fernanda; Jiménez-Arce, Gerardo; G. Naranjo, María-Eugenia; Tarazona-Santos, Eduardo; Fariñas, Humberto; Barrantes, Ramiro; Llerena, Adrián; CEIBA.FP Consortium for the Ibero-American Network of Pharmacogenomics RIBEF, 2016. Revista de Biología Tropical. 3. 64. 2016. http://dx.doi.org/10.15517/rbt.v64i3.20901 . 10.15517/rbt.v64i3.20901 . Revista de Biología Tropical

Argininemia and plasma arginine bioavailability - predictive factors of mortality in the severe trauma patients?

Costa BP; Martins P; Veríssimo C; Simões M; Tomé M; Grazina M; Pimentel J; Castro-Sousa F, 2016. 2016. http://europepmc.org/abstract/med/27582779 . 10.1186/s12986-016-0118-6 .

Ketogenic diets: from cancer to mitochondrial diseases and beyond

Branco, Ana F.; Ferreira, André; Simões, Rui F.; Magalhães-Novais, Sílvia; Zehowski, Cheryl; Cope, Elisabeth; Silva, Ana Marta; et al, 2016. European Journal of Clinical Investigation. 285 - 298. 3. 46. 2016. http://dx.doi.org/10.1111/eci.12591 . 10.1111/eci.12591 . published European Journal of Clinical Investigation

Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders.

Yubero D; Montero R; Martín MA; Montoya J; Ribes A; Grazina M; Trevisson E; et al, 2016. 2016. http://europepmc.org/abstract/med/27374853 . 10.1016/j.mito.2016.06.007 .

Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndrome with COX deficiency.

Ribeiro C; do Carmo Macário M; Viegas AT; Pratas J; Santos MJ; Simões M; Mendes C; et al, 2016. 2016. http://europepmc.org/abstract/med/27756633 . 10.1016/j.mito.2016.10.004 .

Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).

Souza AO; Tasso MJ; Oliveira AM; Pereira LC; Duarte FV; Oliveira DP; Palmeira CM; Dorta DJ, 2016. 2016. http://europepmc.org/abstract/med/27060917 . 10.1111/bcpt.12598 .

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Lassed, Somia; Deus, Claudia M.; Lourenco, Nuno; Dahdouh, Abderrezak; Rizvanov, Albert A.; Oliveira, Paulo J.; Zama, Djamila, 2016. Biomed Research International. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000387239100001&KeyUID=WOS:000387239100001 . 10.1155/2016/5730569 . Biomed Research International

Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

Pereira, Goncalo C.; Pereira, Susana P.; Tavares, Ludgero C.; Carvalho, Filipa S.; Magalhaes-Novais, Silvia; Barbosa, Ines A.; Santos, Maria S.; et al, 2016. Mitochondrion. 95 - 104. 30. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384037300011&KeyUID=WOS:000384037300011 . 10.1016/j.mito.2016.07.005 . Mitochondrion

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, Ana Marta; Barbosa, Ines A.; Seabra, Catia; Beltrao, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; Cunha-Oliveira, Teresa, 2016. Food and Chemical Toxicology. 148 - 158. 94. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380414900016&KeyUID=WOS:000380414900016 . 10.1016/j.fct.2016.06.001 . Food and Chemical Toxicology

Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis

Goncalves, Ines O.; Passos, Emanuel; Diogo, Catia V.; Rocha-Rodrigues, Silvia; Santos-Alves, Estela; Oliveira, Paulo J.; Ascensao, Antonio; Magalhaes, Jose, 2016. Applied Physiology Nutrition and Metabolism. 298 - 306. 3. 41. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375441400010&KeyUID=WOS:000375441400010 . 10.1139/apnm-2015-0470 . Applied Physiology Nutrition and Metabolism

Establishing a new model for toxicological evaluation combining Sulforhodamine B and resazurin in human cells

Silva, F. S. G.; Starostina, I. G.; Ivanova, V. V.; Rizvanov, A. A.; Oliveira, P. J.; Pereira, S. P., 2016. European Journal of Clinical Investigation. 66 - 66. 46. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375378000155&KeyUID=WOS:000375378000155 . European Journal of Clinical Investigation

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

Marques-Aleixo, I; Santos-Alves, E.; Balca, M. M.; Moreira; Oliveira, P. J.; Magalhaes, J.; Ascensao, A., 2016. Mitochondrion. 43 - 57. 26. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370768100006&KeyUID=WOS:000370768100006 . 10.1016/j.mito.2015.12.002 . Mitochondrion

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease

Bernardo, T. C.; Marques-Aleixo, I.; Beleza, J.; Oliveira, P. J.; Ascensao, A.; Magalhaes, J., 2016. Brain Pathology. 648 - 663. 5. 26. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384678400008&KeyUID=WOS:000384678400008 . 10.1111/bpa.12403 . Brain Pathology

Determination of Metabolic Viability and Cell Mass Using a Tandem Resazurin/Sulforhodamine B Assay.

Silva FS; Starostina IG; Ivanova VV; Rizvanov AA; Oliveira PJ; Pereira SP, 2016. Current protocols in toxicology. 2016. http://europepmc.org/abstract/med/27145111 . 10.1002/cptx.1 . Current protocols in toxicology

Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications.

Rizvanov AA; Persson J; Sahin F; Bellusci S; Oliveira PJ, 2016. Stem cells international. 2016. http://europepmc.org/abstract/med/27999598 . 10.1155/2016/3157365 . Stem cells international

Targeting Mitochondria in Cardiovascular Diseases

Silva, Filomena S. G.; Simoes, Rui F.; Couto, Renata; Oliveira, Paulo J., 2016. Current Pharmaceutical Design. 5698 - 5717. 37. 22. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388519800006&KeyUID=WOS:000388519800006 . 10.2174/1381612822666160822150243 . Current Pharmaceutical Design

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

Silva, Filomena S. G.; Oliveira, Paulo J.; Duarte, Maria F., 2016. Journal of Agricultural and Food Chemistry. 2991 - 3008. 15. 64. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000374812700001&KeyUID=WOS:000374812700001 . 10.1021/acs.jafc.5b06021 . Journal of Agricultural and Food Chemistry

Lethal Neonatal LTBL Associated with Biallelic EARS2 Variants: Case Report and Review of the Reported Neuroradiological Features.

Oliveira R; Sommerville EW; Thompson K; Nunes J; Pyle A; Grazina M; Chinnery PF; et al, 2016. JIMD Reports. 61 - 68. 33. 2016. http://europepmc.org/abstract/med/27571996 . 10.1007/8904_2016_581 . published JIMD Reports

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Naia, Luana; Ferreira, I. Luísa; Cunha-Oliveira, Teresa; Duarte, Ana I.; Ribeiro, Márcio; Rosenstock, Tatiana R.; Laço, Mário N.; et al, 2015. Molecular Neurobiology. 331 - 348. 1. 51. 2015. http://dx.doi.org/10.1007/s12035-014-8735-4 . 10.1007/s12035-014-8735-4 . published Molecular Neurobiology

Protective role of necrostatin-1 in acute myocardial infarction.

Carbone F; Oliveira PJ; Montecucco F, 2015. European journal of clinical investigation. 2015. http://europepmc.org/abstract/med/26584011 . 10.1111/eci.12568 . European journal of clinical investigation

High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme.

Apellániz-Ruiz M; Inglada-Pérez L; Naranjo ME; Sánchez L; Mancikova V; Currás-Freixes M; de Cubas AA; et al, 2015. 2015. http://europepmc.org/abstract/med/25348618 . 10.1038/tpj.2014.67 .

Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-targeting Molecules.

Deus CM; Santos GL; Loureiro R; Vega-Naredo I; Faneca H; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25666790 .

Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies.

Tavares LC; Jarak I; Nogueira FN; Oliveira PJ; Carvalho RA, 2015. 2015. http://europepmc.org/abstract/med/25524585 . 10.1111/eci.12358 .

Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.

Teixeira J; Soares P; Benfeito S; Murphy MP; Oliveira PJ; Borges F, 2015. 2015. http://europepmc.org/abstract/med/25634268 . 10.1007/978-1-4939-2288-8_6 .

Comment on 'mycophenolic acid attenuates the tumour necrosis factor-a-mediated proinflammatory response in endothelial cells by blocking the MAPK/NF-¿B and ROS pathways' by Olejarz et al.

Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25413447 . 10.1111/eci.12382 .

Bisphenol A as epigenetic modulator: setting the stage for carcinogenesis?

Ferreira LL; Couto R; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25524584 . 10.1111/eci.12362 .

Measuring p66Shc Signaling Pathway Activation and Mitochondrial Translocation in Cultured Cells.

Wieckowski MR; Deus CM; Couto R; Oparka M; Lebiedzinska-Arciszewska M; Duszynski J; Oliveira PJ, 2015. Current protocols in toxicology. 2015. http://europepmc.org/abstract/med/26523473 . 10.1002/0471140856.tx2506s66 . Current protocols in toxicology

Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts.

Deus CM; Zehowski C; Nordgren K; Wallace KB; Skildum A; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25997894 . 10.1016/j.tox.2015.05.001 .

Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling.

Santos-Alves E; Marques-Aleixo I; Rizo-Roca D; Torrella JR; Oliveira PJ; Magalhães J; Ascensão A, 2015. 2015. http://europepmc.org/abstract/med/26135624 . 10.1016/j.lfs.2015.06.007 .

Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin.

Rodrigues ET; Pardal MÂ; Laizé V; Cancela ML; Oliveira PJ; Serafim TL, 2015. 2015. http://europepmc.org/abstract/med/26319055 . 10.1016/j.envpol.2015.08.026 .

Genetic Variation of MT-ND Genes in Frontotemporal Lobar Degeneration: Biochemical Phenotype-Genotype Correlation.

Gaspar R; Santana I; Mendes C; Fernandes AS; Duro D; Simões M; Luís D; Santos MJ; Grazina M, 2015. 2015. http://europepmc.org/abstract/med/25871488 . 10.1159/000380766 .

p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts.

Sampaio SF; Branco AF; Wojtala A; Vega-Naredo I; Wieckowski MR; Oliveira PJ; Sampaio, Susana F.; et al, 2015. Archives of Toxicology. 1669 - 1684. 7. 90. 2015. http://europepmc.org/abstract/med/26318906 . 10.1007/s00204-015-1583-9 . Archives of Toxicology

Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.

Jiménez-Chillarón JC; Nijland MJ; Ascensão AA; Sardão VA; Magalhães J; Hitchler MJ; Domann FE; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25774863 . 10.1080/15592294.2015.1020267 .

Effects of Moderate Global Maternal Nutrient Reduction on Fetal Baboon Renal Mitochondrial Gene Expression at 0.9 Gestation.

Pereira SP; Oliveira PJ; Tavares LC; Moreno AJ; Cox LA; Nathanielsz PW; Nijland MJ, 2015. 2015. http://europepmc.org/abstract/med/25761880 . 10.1152/ajprenal.00419.2014 .

Analysis of pro-apoptotic protein trafficking to and from mitochondria.

Vega-Naredo I; Cunha-Oliveira T; Serafim TL; Sardao VA; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/25308496 . 10.1007/978-1-4939-1875-1_14 .

Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress.

Marques-Aleixo I; Santos-Alves E; Mariani D; Rizo-Roca D; Padrão AI; Rocha-Rodrigues S; Viscor G; et al, 2015. 2015. http://europepmc.org/abstract/med/25446396 . 10.1016/j.mito.2014.10.008 .

Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype.

Branco AF; Pereira SP; Gonzalez S; Gusev O; Rizvanov AA; Oliveira PJ, 2015. 2015. http://europepmc.org/abstract/med/26121149 . 10.1371/journal.pone.0129303 .

Role of mtDNA-related mitoepigenetic phenomena in cancer

Ferreira, André; Serafim, Teresa L; Sardão, Vilma A; # Cunha-Oliveira, Teresa, 2015. European Journal of Clinical Investigation. 44 - 49. S1. 45. 2015. http://dx.doi.org/10.1111/eci.12359 . 10.1111/eci.12359 . published European Journal of Clinical Investigation

Measuring Mitochondrial Membrane Potential with a Tetraphenylphosphonium-Selective Electrode.

Moreno AJ; Santos DL; Magalhães-Novais S; Oliveira PJ, 2015. Current protocols in toxicology. 2015. http://europepmc.org/abstract/med/26250398 . 10.1002/0471140856.tx2505s65 . Current protocols in toxicology

AS TOXICODEPENDÊNCIAS ¿ A PROCURA INCESSANTE DA FELICIDADE? / Drug addictions - the incessant search for happiness?

Grazina, Manuela, 2015. Adictologia. 8 - 9. 1. 2015. published Adictologia

Pharmacogenomics of cocaine addiction.

Grazina, Manuela; Macedo, C; Ribeiro, C.; Curto, J, 2015. Adictologia. 28 - 39. 1. 2015. published Adictologia

Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells.

Loureiro R; Magalhães-Novais S; Mesquita KA; Baldeiras I; Sousa IS; Tavares LC; Barbosa IA; Oliveira PJ; Vega-Naredo I, 2015. 2015. http://europepmc.org/abstract/med/26025920 .

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers.

Marques-Aleixo I; Santos-Alves E; Balça MM; Rizo-Roca D; Moreira PI; Oliveira PJ; Magalhães J; Ascensão A, 2015. 2015. http://europepmc.org/abstract/med/26116519 . 10.1016/j.neuroscience.2015.06.027 .

Pharmacogenetics in Central American healthy volunteers: interethnic variability.

Céspedes-Garro C; Naranjo ME; Ramírez R; Serrano V; Fariñas H; Barrantes R; LLerena A; CEIBA Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF, 2015. 2015. http://europepmc.org/abstract/med/25490028 .

PPARa Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.

Pantazi E; Folch-Puy E; Bejaoui M; Panisello A; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/26539534 . 10.1155/2015/894679 .

Regulation of Mitochondrial Function and its Impact in Metabolic Stress.

Duarte FV; Amorim JA; Palmeira CM; Rolo AP, 2015. 2015. http://europepmc.org/abstract/med/25973983 . 10.2174/0929867322666150514095910 .

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

Görlach A; Dimova EY; Petry A; Martínez-Ruiz A; Hernansanz-Agustín P; Rolo AP; Palmeira CM; Kietzmann T, 2015. 2015. http://europepmc.org/abstract/med/26339717 . 10.1016/j.redox.2015.08.016 .

The Emerging Role of MitomiRs in the Pathophysiology of Human Disease.

Duarte FV; Palmeira CM; Rolo AP, 2015. 2015. http://europepmc.org/abstract/med/26663182 . 10.1007/978-3-319-22671-2_8 .

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Forkink, M.; Basit, F.; Teixeira, J.; Swarts, H.G.; Koopman, W.J.H.; Willems, P.H.G.M., 2015. Redox Biology. 607 - 616. 6. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945395305&partnerID=MN8TOARS . 10.1016/j.redox.2015.09.003 . published Redox Biology

Impairment of mitochondrial energy metabolism of two marine fish by in vitro mercuric chloride exposure.

Mieiro CL; Pardal M; Duarte A; Pereira E; Palmeira CM, 2015. 2015. http://europepmc.org/abstract/med/26026249 . 10.1016/j.marpolbul.2015.05.054 .

Editorial: Metabolic Diseases: Drugs and Mitochondrial Targets.

Palmeira CM; Rolo AP; Palmeira, C.M.; Rolo, A.P., 2015. Current Medicinal Chemistry. 20. 22. 2015. http://europepmc.org/abstract/med/26549543 . 10.2174/092986732220150722123617 . Current Medicinal Chemistry

Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.

Pantazi E; Zaouali MA; Bejaoui M; Folch-Puy E; Ben Abdennebi H; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/25684941 . 10.3748/wjg.v21.i6.1765 .

Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.

Pantazi E; Bejaoui M; Zaouali MA; Folch-Puy E; Pinto Rolo A; Panisello A; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/26185373 . 10.3748/wjg.v21.i26.8021 .

Biochemical and physiological responses of Carcinus maenas to temperature and the fungicide azoxystrobin.

Rodrigues ET; Moreno A; Mendes T; Palmeira C; Pardal MÂ, 2015. 2015. http://europepmc.org/abstract/med/25835271 . 10.1016/j.chemosphere.2015.03.011 .

High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes.

Teodoro JS; Varela AT; Rolo AP; Palmeira CM, 2014. 2014. http://europepmc.org/abstract/med/24842072 . 10.1007/s12263-014-0406-6 .

Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments.

Gonçalves IO; Passos E; Rocha-Rodrigues S; Diogo CV; Torrella JR; Rizo D; Viscor G; et al, 2014. 2014. http://europepmc.org/abstract/med/24727595 . 10.1016/j.mito.2014.03.012 .

Carriers for metal complexes on tumour cells: the effect of cyclodextrins vs CNTs on the model guest phenanthroline-5,6-dione trithiacyclononane ruthenium(II) chloride

Braga, S. S.; Marques, J.; Heister, E.; Diogo, C. V.; Oliveira, P. J.; Paz, F. A.; Santos, T. M.; Marques, M. P., 2014. Biometals. 2014. 10.1007/s10534-014-9725-8 . Biometals

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells.

Vega-Naredo I; Loureiro R; Mesquita KA; Barbosa IA; Tavares LC; Branco AF; Erickson JR; et al, 2014. 2014. http://europepmc.org/abstract/med/24832466 . 10.1038/cdd.2014.66 .

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

Carmo MR; Menezes AP; Nunes AC; Pliássova A; Rolo AP; Palmeira CM; Cunha RA; Canas PM; Andrade GM, 2014. 2014. http://europepmc.org/abstract/med/24508709 . 10.1016/j.neuropharm.2014.01.045 .

ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco AF; Moreira AC; Cunha-Oliveira T; Couto R; Sardao VA; Rizvanov AA; Palotas A; Oliveira PJ, 2014. Current drug targets. 2014. http://europepmc.org/abstract/med/25182471 . 10.2174/1389450115666140902124230 . Current drug targets

Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

Céspedes-Garro, Carolina; Jiménez-Arce, Gerardo; Naranjo, María-Eugenia G.; Barrantes, Ramiro; LLerena, Adrián; Institucional, Autor, 2014. Revista de Biología Tropical. 4. 62. 2014. http://dx.doi.org/10.15517/rbt.v62i4.12916 . 10.15517/rbt.v62i4.12916 . Revista de Biología Tropical

Exercise mitigates diclofenac-induced liver mitochondrial dysfunction.

Santos-Alves E; Marques-Aleixo I; Coxito P; Balça MM; Rizo-Roca D; Rocha-Rodrigues S; Martins S; et al, 2014. 2014. http://europepmc.org/abstract/med/24889192 . 10.1111/eci.12285 .

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts

Moreira, Ana C; Branco, Ana F; Sampaio, Susana F; Cunha-Oliveira, Teresa; Martins, Tatiana R; Holy, Jon; Oliveira, Paulo J; et al, 2014. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2468 - 2478. 12. 1842. 2014. http://hdl.handle.net/10316/41109 . 10.1016/j.bbadis.2014.09.015 . published Biochimica et Biophysica Acta-Molecular Basis of Disease

Modulation of cardiac mitochondrial permeability transition and apoptotic signaling by endurance training and intermittent hypobaric hypoxia

Magalhães, J.; Gonçalves, I. O.; Lumini-Oliveira, J.; Marques-Aleixo, I.; Passos, E.; Rocha-Rodrigues, S.; Machado, N. G.; et al, 2014. Int J Cardiol. 2014. 10.1016/j.ijcard.2014.02.011 . Int J Cardiol

Targeting mitochondrial function for the treatment of breast cancer.

Deus CM; Coelho AR; Serafim TL; Oliveira PJ, 2014. 2014. http://europepmc.org/abstract/med/25365234 . 10.4155/fmc.14.100 .

Mitochondrial membrane lipids in life and death and their molecular modulation by diet: tuning the furnace.

Monteiro JP; Morais CM; Oliveira PJ; Jurado AS, 2014. Current drug targets. 2014. http://europepmc.org/abstract/med/24953065 . 10.2174/1389450115666140623115315 . Current drug targets

Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis.

Gonçalves IO; Maciel E; Passos E; Torrella JR; Rizo D; Viscor G; Rocha-Rodrigues S; et al, 2014. 2014. http://europepmc.org/abstract/med/25063232 . 10.1016/j.biocel.2014.07.011 .

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

Moreira AC; Branco AF; Sampaio SF; Cunha-Oliveira T; Martins TR; Holy J; Oliveira PJ; Sardão VA, 2014. 2014. http://europepmc.org/abstract/med/25283819 . 10.1016/j.bbadis.2014.09.015 .

Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis

Abrantes, A.M.; Tavares, L.C.; Pires, S.; Casalta-Lopes, J.; Mendes, C.; Simões, M.; Grazina, M.M.; Carvalho, R.A.; Botelho, M.F., 2014. BioMed Research International. 2014. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904819813&partnerID=MN8TOARS . 10.1155/2014/759791 . BioMed Research International

Vital imaging of multicellular spheroids

Oliveira, P. J.; Perkins, E. L.; Holy, J., 2014. Methods Mol Biol. 227 - 41. 1075. 2014. 10.1007/978-1-60761-847-8_11 . Methods Mol Biol

ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco, Ana F; Moreira, Ana C; Cunha-Oliveira, Teresa; Couto, Renata; Sardao, Vilma A; Rizvanov, Albert A; Palotas, Andras; et al, 2014. Current Drug Targets. 956 - 964. 10. 15. 2014. http://dx.doi.org/10.2174/1389450115666140902124230 . 10.2174/1389450115666140902124230 . published Current Drug Targets

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice.

Teodoro JS; Zouhar P; Flachs P; Bardova K; Janovska P; Gomes AP; Duarte FV; et al, 2014. 2014. http://europepmc.org/abstract/med/24310401 . 10.1038/ijo.2013.230 .

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J., 2014. Medicinal Research Reviews. 106 - 135. 1. 34. 2014. 10.1002/med.21280 . Medicinal Research Reviews

New derivatives of lupane triterpenoids disturb breast cancer mitochondria and induce cell death.

Serafim TL; Carvalho FS; Bernardo TC; Pereira GC; Perkins E; Holy J; Krasutsky DA; et al, 2014. 2014. http://europepmc.org/abstract/med/25245673 . 10.1016/j.bmc.2014.08.013 .

Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity.

Ivanova VV; Khaiboullina SF; Cherenkova EE; Martynova EV; Nevzorova TA; Kunst MA; Sibgatullin TB; et al, 2014. 2014. http://europepmc.org/abstract/med/25562166 . 10.1159/000369663 .

The Role of microRNAs in Mitochondria: Small Players Acting Wide.

Duarte FV; Palmeira CM; Rolo AP, 2014. 2014. http://europepmc.org/abstract/med/25264560 . 10.3390/genes5040865 .

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Silva, T.; Reis, J.; Teixeira, J.; Borges, F., 2014. Ageing Research Reviews. 116 - 145. 1. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899683262&partnerID=MN8TOARS . 10.1016/j.arr.2014.03.008 . published Ageing Research Reviews

Hydroxycinnamic acid antioxidants: An electrochemical overview

Teixeira, J.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881540701&partnerID=MN8TOARS . 10.1155/2013/251754 . published BioMed Research International

CYP2D6-1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers

Llerena, A.; Dorado, P.; Ramírez, R.; Calzadilla, L.R.; Peñas-Lledó, E.; Álvarez, M.; Naranjo, M.E.; González, I.; Pérez, B., 2013. Pharmacogenomics. 1973 - 1977. 16. 14. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889046926&partnerID=MN8TOARS . 10.2217/pgs.13.181 . Pharmacogenomics

Eccentric exercise transiently affects mice skeletal muscle mitochondrial function

Magalhaes, Jose; Fraga, Marta; Lumini-Oliveira, Jose; Goncalves, Ines; Costa, Manoel; Ferreira, Rita; Oliveira, Paulo J.; Ascensao, Antonio, 2013. Applied Physiology Nutrition and Metabolism-Physiologie Appliquee Nutrition Et Metabolisme. 401 - 409. 4. 38. 2013. 10.1139/apnm-2012-0226 . Applied Physiology Nutrition and Metabolism-Physiologie Appliquee Nutrition Et Metabolisme

Cumulative Mitoxantrone-induced Haematological and Hepatic Adverse Effects in a Sub-Chronic In Vivo Study.

Rossato LG; Costa VM; Dallegrave E; Arbo M; Dinis-Oliveira RJ; Santos-Silva A; Duarte JA; et al, 2013. 2013. http://europepmc.org/abstract/med/24119282 . 10.1111/bcpt.12143 .

Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, 2013. 2013. http://europepmc.org/abstract/med/23292031 . 10.1007/s11010-012-1555-9 .

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M., 2013. Mitochondrion. 637 - 646. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS . 10.1016/j.mito.2013.09.002 . Mitochondrion

Mitochondrial and liver oxidative stress alterations induced by N-butyl-N-(4-hydroxybutyl)nitrosamine: relevance for hepatotoxicity

Oliveira, Maria M.; Teixeira, Jose C.; Vasconcelos-Nobrega, Carmen; Felix, Luis M.; Sardao, Vilma A.; Colaco, Aura A.; Oliveira, Paula A.; Peixoto, Francisco P., 2013. Journal of Applied Toxicology. 434 - 443. 6. 33. 2013. 10.1002/jat.1763 . published Journal of Applied Toxicology

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

Rossato, L.G.; Costa, V.M.; Vilas-Boas, V.; De Lourdes Bastos, M.; Rolo, A.; Palmeira, C.; Remião, F., 2013. Cardiovascular Toxicology. 413 - 425. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890559945&partnerID=MN8TOARS . 10.1007/s12012-013-9224-0 . Cardiovascular Toxicology

Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions.

Monteiro JP; Oliveira PJ; Jurado AS, 2013. 2013. http://europepmc.org/abstract/med/23827885 . 10.1016/j.plipres.2013.06.002 .

Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids

Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F., 2013. European Journal of Medicinal Chemistry. 289 - 296. 62. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS . 10.1016/j.ejmech.2012.12.049 . published European Journal of Medicinal Chemistry

Ipilimumab and vemurafenib: two different routes for targeting melanoma.

Burgeiro A; Mollinedo F; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23862981 . 10.2174/15680096113139990080 .

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier

Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M., 2013. Toxicology in Vitro. 2160 - 2168. 8. 27. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS . 10.1016/j.tiv.2013.08.009 . Toxicology in Vitro

Exercise as a therapeutic tool to prevent mitochondrial degeneration in nonalcoholic steatohepatitis.

Gonçalves IO; Oliveira PJ; Ascensão A; Magalhães J, 2013. European journal of clinical investigation. 2013. http://europepmc.org/abstract/med/24033085 . 10.1111/eci.12146 . European journal of clinical investigation

Biological insight, high-throughput datasets and the nature of neuro-degenerative disorders.

Valente AX; Oliveira PJ; Khaiboullina SF; Palotás A; Rizvanov AA, 2013. 2013. http://europepmc.org/abstract/med/23937175 . 10.2174/13892002113149990100 .

Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity.

Monteiro JP; Silva AM; Jurado AS; Oliveira PJ, 2013. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013. http://europepmc.org/abstract/med/23933359 . 10.1016/j.fct.2013.07.073 . Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Mitochondria in cancer stem cells: a target for therapy.

Loureiro R; Mesquita KA; Oliveira PJ; Vega-Naredo I, 2013. 2013. http://europepmc.org/abstract/med/23360288 . 10.2174/18722148113079990006 .

Rapid human melanoma cell death induced by sanguinarine through oxidative stress

Burgeiro, A., 2013. European Journal of Pharmacology. 109 - 118. 1-3. 705. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875293604&partnerID=MN8TOARS . 10.1016/j.ejphar.2013.02.035 . European Journal of Pharmacology

Disrupted ATP synthase activity and mitochondrial hyperpolarisation- dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients

Lebiedzinska, M., 2013. International Journal of Biochemistry and Cell Biology. 141 - 150. 1. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870685606&partnerID=MN8TOARS . 10.1016/j.biocel.2012.07.020 . International Journal of Biochemistry and Cell Biology

Cardiac mitochondrial dysfunction during hyperglycemia - The role of oxidative stress and p66Shc signaling

Diogo, C.V., 2013. International Journal of Biochemistry and Cell Biology. 114 - 122. 1. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870696911&partnerID=MN8TOARS . 10.1016/j.biocel.2012.07.004 . International Journal of Biochemistry and Cell Biology

Oxidative Stress and Drugs of Abuse: An Update

# Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R., 2013. Mini-Reviews in Organic Chemistry. 321 - 334. 4. 10. 2013. http://dx.doi.org/10.2174/1570193X113106660026 . 10.2174/1570193X113106660026 . published Mini-Reviews in Organic Chemistry

Nonketotic hyperglycinemia: A cause of encephalopathy in children

Veríssimo, C.; Garcia, P.; Simões, M.; Robalo, C.; Henriques, R.; Diogo, L.; Grazina, M., 2013. Journal of Child Neurology. 251 - 254. 2. 28. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872867628&partnerID=MN8TOARS . 10.1177/0883073812441063 . Journal of Child Neurology

Antioxidant therapy: Still in search of the 'magic bullet'

Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F., 2013. Mitochondrion. 427 - 435. 5. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS . 10.1016/j.mito.2012.12.002 . published Mitochondrion

Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: Pharmacogenetic implications

Albuquerque, J.; Ribeiro, C.; Naranjo, M.E.G.; Llerena, A.; Grazina, M., 2013. Personalized Medicine. 709 - 718. 7. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884149194&partnerID=MN8TOARS . 10.2217/pme.13.56 . Personalized Medicine

Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss

d'Almeida, O.C.; Mateus, C.; Reis, A.; Grazina, M.M.; Castelo-Branco, M., 2013. NeuroImage. 222 - 230. 81. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878825124&partnerID=MN8TOARS . 10.1016/j.neuroimage.2013.05.032 . NeuroImage

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, Rita; * Cunha-Oliveira, Teresa; Rego, Ana Cristina, 2013. Free Radical Biology and Medicine. 186 - 201. 62. 2013. http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.042 . 10.1016/j.freeradbiomed.2013.05.042 . published Free Radical Biology and Medicine

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition

Bernardo, Telma C.; Cunha-Oliveira, Teresa; Serafim, Teresa L.; Holy, Jon; Krasutsky, Dmytro; Kolomitsyna, Oksana; Krasutsky, Pavel; Moreno, António M.; Oliveira, Paulo J., 2013. Bioorganic & Medicinal Chemistry. 7239 - 7249. 23. 21. 2013. http://dx.doi.org/10.1016/j.bmc.2013.09.066 . 10.1016/j.bmc.2013.09.066 . published Bioorganic & Medicinal Chemistry

Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes

Montero, R.; Grazina, M.; López-Gallardo, E.; Montoya, J.; Briones, P.; Navarro-Sastre, A.; Land, J.M.; et al, 2013. Mitochondrion. 337 - 341. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877800522&partnerID=MN8TOARS . 10.1016/j.mito.2013.04.001 . Mitochondrion

Evaluation of drug-metabolizing enzyme hydroxylation phenotypes in Hispanic populations: The CEIBA cocktail

De Andrés, F.; Sosa-Macías, M.; Lazalde-Ramos, B.P.; Naranjo, M.E.G.; Tarazona-Santos, E.; Llerena, A.; Moya, G.E.; et al, 2013. Drug Metabolism and Drug Interactions. 135 - 146. 3. 28. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888082961&partnerID=MN8TOARS . 10.1515/dmdi-2013-0020 . Drug Metabolism and Drug Interactions

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.

Pereira SL; Grãos M; Rodrigues AS; Anjo SI; Carvalho RA; Oliveira PJ; Arenas E; Ramalho-Santos J, 2013. 2013. http://europepmc.org/abstract/med/24312632 . 10.1371/journal.pone.0082095 .

Citrullinemia stimulation test in the evaluation of the intestinal function | Citrulinemia prueba de estimulación en la evaluación de la función intestinal

Costa, B.P.; Serôdio, M.; Simões, M.; Veríssimo, C.; Sousa, F.C.; Grazina, M., 2013. Nutricion Hospitalaria. 202 - 210. 1. 28. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872811329&partnerID=MN8TOARS . 10.3305/nh.2013.28.1.6243 . Nutricion Hospitalaria

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP; Price NL; Ling AJ; Moslehi JJ; Montgomery MK; Rajman L; White JP; et al, 2013. 2013. http://europepmc.org/abstract/med/24360282 . 10.1016/j.cell.2013.11.037 .

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment.

Rossato LG; Costa VM; Dallegrave E; Arbo M; Silva R; Ferreira R; Amado F; et al, 2013. 2013. http://europepmc.org/abstract/med/24096626 . 10.1007/s12012-013-9230-2 .

Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., 2013. Toxicology Letters. 298 - 306. 3. 219. 2013. http://dx.doi.org/10.1016/j.toxlet.2013.03.025 . 10.1016/j.toxlet.2013.03.025 . published Toxicology Letters

Alzheimer's disease and antioxidant therapy: How long how far?

Teixeira, J.; Silva, T.; Andrade, P.B.; Borges, F., 2013. Current Medicinal Chemistry. 2939 - 2952. 24. 20. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880283997&partnerID=MN8TOARS . 10.2174/1871523011320240001 . published Current Medicinal Chemistry

Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics.

Monteiro JP; Pereira CV; Silva AM; Maciel E; Baldeiras I; Peixoto F; Domingues MR; Jurado AS; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23636270 . 10.1007/s00204-013-1068-7 .

Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways

Silva, T.; Teixeira, J.; Remião, F.; Borges, F., 2013. Angewandte Chemie - International Edition. 1110 - 1121. 4. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872382364&partnerID=MN8TOARS . 10.1002/anie.201204964 . published Angewandte Chemie - International Edition

Breath tests with novel 13c-substrates for clinical studies of liver mitochondrial function in health and disease.

Grattagliano I; Bonfrate L; Oliveira PJ; Castorani L; Ruggiero V; Valenzano AT; Ascensão A; Buzoianu A; Portincasa P, 2013. 2013. http://europepmc.org/abstract/med/24443072 .

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity.

Rossato LG; Costa VM; de Pinho PG; Arbo MD; de Freitas V; Vilain L; de Lourdes Bastos M; Palmeira C; Remião F, 2013. 2013. http://europepmc.org/abstract/med/23545721 . 10.1007/s00204-013-1040-6 .

The NAD ratio redox paradox: why does too much reductive power cause oxidative stress?

Teodoro JS; Rolo AP; Palmeira CM, 2013. 2013. http://europepmc.org/abstract/med/23256455 . 10.3109/15376516.2012.759305 .

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition.

Bernardo TC; Cunha-Oliveira T; Serafim TL; Holy J; Krasutsky D; Kolomitsyna O; Krasutsky P; Moreno AM; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/24156937 . 10.1016/j.bmc.2013.09.066 .

Antenatal manifestations of mitochondrial disorders

Tavares, M.V.; Santos, M.J.; Domingues, A.P.; Pratas, J.; Mendes, C.; Simões, M.; Moura, P.; Diogo, L.; Grazina, M., 2013. Journal of Inherited Metabolic Disease. 805 - 811. 5. 36. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884350140&partnerID=MN8TOARS . 10.1007/s10545-012-9567-x . Journal of Inherited Metabolic Disease

Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: differential activation of stress and survival pathways.

Branco AF; Sampaio SF; Wieckowski MR; Sardão VA; Oliveira PJ, 2013. 2013. http://europepmc.org/abstract/med/23958426 . 10.1016/j.biocel.2013.08.006 .

Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling.

Magalhães J; Falcão-Pires I; Gonçalves IO; Lumini-Oliveira J; Marques-Aleixo I; Dos Passos E; Rocha-Rodrigues S; et al, 2013. 2013. http://europepmc.org/abstract/med/24012275 . 10.1016/j.ijcard.2013.08.001 .

A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects

Monteiro, Joao P.; Martins, Andre F.; Nunes, Claudia; Morais, Catarina M.; Lucio, Marlene; Reis, Salette; Pinheiro, Teresa J. T.; et al, 2013. Biochimica Et Biophysica Acta-Biomembranes. 1899 - 1908. 8. 1828. 2013. 10.1016/j.bbamem.2013.04.006 . Biochimica Et Biophysica Acta-Biomembranes

Modulation of hepatic redox status and mitochondrial metabolism by exercise: therapeutic strategy for liver diseases.

Ascensão A; Martins MJ; Santos-Alves E; Gonçalves IO; Portincasa P; Oliveira PJ; Magalhães J, 2013. 2013. http://europepmc.org/abstract/med/23880173 . 10.1016/j.mito.2013.07.002 .

Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology

Rocha-Rodrigues, Silvia; Santos-Alves, Estela; Coxito, Pedro M.; Marques-Aleixo, Ines; Passos, Emanuel; Guimaraes, Joao T.; Martins, Maria J.; et al, 2013. Life Sciences. 329 - 337. 8. 93. 2013. 10.1016/j.lfs.2013.07.004 . Life Sciences

Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats

Pereira, Susana P.; Pereira, Goncalo C.; Pereira, Claudia V.; Carvalho, Filipa S.; Cordeiro, Marilia H.; Mota, Paula C.; Ramalho-Santos, Joao; Moreno, Antonio J.; Oliveira, Paulo J., 2013. Environmental Pollution. 281 - 290. 180. 2013. 10.1016/j.envpol.2013.05.049 . Environmental Pollution

Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., 2013. Life Sciences. 1157 - 1164. 24-26. 92. 2013. http://dx.doi.org/10.1016/j.lfs.2013.04.016 . 10.1016/j.lfs.2013.04.016 . published Life Sciences

Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition

Burgeiro, Ana; Pereira, Claudia V.; Carvalho, Filipa S.; Pereira, Goncalo C.; Mollinedo, Faustino; Oliveira, Paulo J., 2013. Mitochondrion. 25 - 35. 1. 13. 2013. 10.1016/j.mito.2012.11.003 . Mitochondrion

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

Grattagliano, Ignazio; Diogo, Catia V.; Mastrodonato, Maria; de Bari, Ornella; Persichella, Michele; Wang, David Q. H.; Liquori, Adriana; et al, 2013. World Journal of Gastroenterology. 3007 - 3017. 20. 19. 2013. 10.3748/wjg.v19.i20.3007 . World Journal of Gastroenterology

Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution

Alves, M.G., 2012. Journal of Cardiovascular Pharmacology. 151 - 157. 2. 59. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857063384&partnerID=MN8TOARS . 10.1097/FJC.0b013e3182391d17 . Journal of Cardiovascular Pharmacology

Toxicity evaluation of some traditional African spices on breast cancer cells and isolated rat hepatic mitochondria

Choumessi, A.T., 2012. Food and Chemical Toxicology. 4199 - 4208. 11. 50. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866522308&partnerID=MN8TOARS . 10.1016/j.fct.2012.08.008 . Food and Chemical Toxicology

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

Pereira, C.V., 2012. Expert Opinion on Drug Metabolism and Toxicology. 219 - 237. 2. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856086570&partnerID=MN8TOARS . 10.1517/17425255.2012.645536 . Expert Opinion on Drug Metabolism and Toxicology

Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation

Grattagliano, I., 2012. Clinical Biochemistry. 610 - 618. 9. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861230299&partnerID=MN8TOARS . 10.1016/j.clinbiochem.2012.03.024 . Clinical Biochemistry

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

Oliveira PJ; Carvalho RA; Portincasa P; Bonfrate L; Sardao VA, 2012. 2012. http://europepmc.org/abstract/med/22496981 . 10.1155/2012/365798 .

Evaluation of respiration with clark type electrode in Isolated mitochondria and permeabilized animal cells

Silva, A.M., 2012. Methods in Molecular Biology. 7 - 24. 810. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355193801&partnerID=MN8TOARS . 10.1007/978-1-61779-382-0_2 . Methods in Molecular Biology

Regulation and protection of mitochondrial physiology by sirtuins

Pereira, C.V., 2012. Mitochondrion. 66 - 76. 1. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856527254&partnerID=MN8TOARS . 10.1016/j.mito.2011.07.003 . Mitochondrion

Exercise as a beneficial adjunct therapy during Doxorubicin treatment-Role of mitochondria in cardioprotection

Ascensão, A., 2012. International Journal of Cardiology. 4 - 10. 1. 156. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858070585&partnerID=MN8TOARS . 10.1016/j.ijcard.2011.05.060 . International Journal of Cardiology

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

Marques-Aleixo, I., 2012. Progress in Neurobiology. 149 - 162. 2. 99. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867896217&partnerID=MN8TOARS . 10.1016/j.pneurobio.2012.08.002 . Progress in Neurobiology

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

Pereira, C.V., 2012. Toxicology and Applied Pharmacology. 167 - 181. 2. 264. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866878955&partnerID=MN8TOARS . 10.1016/j.taap.2012.07.030 . Toxicology and Applied Pharmacology

Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies

Barbosa, I.A., 2012. Biochimica et Biophysica Acta - Reviews on Cancer. 238 - 254. 1. 1826. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860808557&partnerID=MN8TOARS . 10.1016/j.bbcan.2012.04.005 . Biochimica et Biophysica Acta - Reviews on Cancer

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse

Perfeito, R.; * Cunha-Oliveira, T.; Rego, A.C., 2012. Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867397192&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.08.569 . Free Radical Biology and Medicine

Minocycline exerts uncoupling and inhibiting effects on mitochondrial respiration through adenine nucleotide translocase inhibition

Cuenca-Lopez, M.D., 2012. Pharmacological Research. 120 - 128. 1. 65. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855986971&partnerID=MN8TOARS . 10.1016/j.phrs.2011.08.007 . Pharmacological Research

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

Ribeiro, Márcio; Rosenstock, Tatiana R.; Cunha-Oliveira, Teresa; Ferreira, Ildete L.; Oliveira, Catarina R.; Rego, A. Cristina, 2012. Free Radical Biology and Medicine. 1857 - 1867. 10. 53. 2012. http://dx.doi.org/10.1016/j.freeradbiomed.2012.09.004 . 10.1016/j.freeradbiomed.2012.09.004 . published Free Radical Biology and Medicine

Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice

Pereira, Frederico C.; Cunha-Oliveira, Teresa; Viana, Sofia D.; Travassos, Ana S.; Nunes, Sara; Silva, Carlos; Prediger, Rui Daniel; et al, 2012. Neurotoxicology and Teratology. 522 - 529. 5. 34. 2012. http://dx.doi.org/10.1016/j.ntt.2012.07.005 . 10.1016/j.ntt.2012.07.005 . published Neurotoxicology and Teratology

Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity

Vega-Naredo, I., 2012. Journal of Pineal Research. 80 - 92. 1. 52. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555174326&partnerID=MN8TOARS . 10.1111/j.1600-079X.2011.00922.x . Journal of Pineal Research

In vitro salicylate does not further impair aging-induced brain mitochondrial dysfunction

Marques-Aleixo, I., 2012. Toxicology. 51 - 59. 1. 302. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866002199&partnerID=MN8TOARS . 10.1016/j.tox.2012.07.018 . Toxicology

Mitochondrionopathy phenotype in doxorubicin-treated wistar rats depends on treatment protocol and is cardiac-specific

Pereira, G.C., 2012. PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862661781&partnerID=MN8TOARS . 10.1371/journal.pone.0038867 . PLoS ONE

Differentiation-dependent doxorubicin toxicity on h9c2 cardiomyoblasts

Branco, A.F., 2012. Cardiovascular Toxicology. 326 - 340. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870546889&partnerID=MN8TOARS . 10.1007/s12012-012-9177-8 . Cardiovascular Toxicology

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F., 2012. Free Radical Research. 600 - 611. 5. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS . 10.3109/10715762.2012.662593 . published Free Radical Research

Endurance training and chronic intermittent hypoxia modulate in vitro salicylate-induced hepatic mitochondrial dysfunction

Ascensão, A., 2012. Mitochondrion. 607 - 616. 6. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869082628&partnerID=MN8TOARS . 10.1016/j.mito.2012.10.007 . Mitochondrion

Valor da citrulinémia na avaliação da função intestinal na síndroma do intestino curto/ Citrullinemia levels in the evaluation of intestinal function in short bowel syndrome

Beatriz Pinto Costa de Almeida; marco Serôdio; Marta Simões; Carla Veríssimo; Grazina, Manuela; F. Castro Sousa, 2012. Revista Portuguesa de Cirurgia. 9 - 19. 20. II. 2012. https://revista.spcir.com/index.php/spcir/article/view/51 . published Revista Portuguesa de Cirurgia

Exposure to dibenzofuran triggers autophagy in lung cells.

Duarte FV; Teodoro JS; Rolo AP; Palmeira CM, 2012. 2012. http://europepmc.org/abstract/med/22173198 . 10.1016/j.toxlet.2011.11.029 .

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.

Rolo AP; Teodoro JS; Palmeira CM, 2012. 2012. http://europepmc.org/abstract/med/22064361 . 10.1016/j.freeradbiomed.2011.10.003 .

Preface

Palmeira, C.M.; Moreno, A.J., 2012. Methods in Molecular Biology. 810. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355193804&partnerID=MN8TOARS . Methods in Molecular Biology

Eating disorder symptoms and CYP2D6 variation in cuban healthy females: A report from the Ibero-American network of pharmacogenetics

Peñas-Lledó, E.M.; González, I.; Dorado, P.; Pérez, B.; Calzadilla, L.R.; Alvárez, M.; Naranjo, M.E.G.; Llerena, A., 2012. Current Pharmacogenomics and Personalized Medicine. 288 - 292. 4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874831233&partnerID=MN8TOARS . Current Pharmacogenomics and Personalized Medicine

Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes

Dorado, P.; Machín, E.; De Andrés, F.; Naranjo, M.-E.G.; Peñas-Lledó, E.M.; Llerena, A.; Dorado P; et al, 2012. Drug Metabolism and Drug Interactions. 217 - 223. 4. 27. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877952687&partnerID=MN8TOARS . 10.1515/dmdi-2012-0018 . Drug Metabolism and Drug Interactions

Losartan hydroxylation phenotype in an Ecuadorian population: Influence of CYP2C9 genetic polymorphism, habits and gender

Dorado, P.; Beltrán, L.J.; MacHín, E.; Peñas-Lledó, E.M.; Terán, E.; Llerena, A., 2012. Pharmacogenomics. 1711 - 1717. 15. 13. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870042059&partnerID=MN8TOARS . 10.2217/pgs.12.160 . Pharmacogenomics

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL; Gomes AP; Ling AJ; Duarte FV; Martin-Montalvo A; North BJ; Agarwal B; et al, 2012. 2012. http://europepmc.org/abstract/med/22560220 . 10.1016/j.cmet.2012.04.003 .

Nerolidol effects on mitochondrial and cellular energetics.

Ferreira FM; Palmeira CM; Oliveira MM; Santos D; Simões AM; Rocha SM; Coimbra MA; Peixoto F, 2012. 2012. http://europepmc.org/abstract/med/22138475 . 10.1016/j.tiv.2011.11.009 .

Pharmacogenetics in Latin American populations: Regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders

Rodeiro, I.; Remírez-Figueredo, D.; García-Mesa, M.; Dorado, P.; Llerena, A.; Moya, G.E.; Ferrero, V.; et al, 2012. Drug Metabolism and Drug Interactions. 57 - 60. 1. 27. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860531136&partnerID=MN8TOARS . 10.1515/dmdi-2012-0006 . Drug Metabolism and Drug Interactions

CYP2C19 (+ or -)*2/(+ or -)*17 Diplotypes: Prognostic impactson patients with acute coronary syndrome

Teixeira, Rogério; Grazina, Manuela; Monteiro, Pedro; Soares, Francisco; Lourenço, Margarida; Pêgo, Guilherme, 2012. World Journal of Cardiovascular Diseases. 260 - 268. 04. 02. 2012. http://dx.doi.org/10.4236/wjcd.2012.24041 . 10.4236/wjcd.2012.24041 . World Journal of Cardiovascular Diseases

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes AP; Duarte FV; Nunes P; Hubbard BP; Teodoro JS; Varela AT; Jones JG; et al, 2012. 2012. http://europepmc.org/abstract/med/22027215 . 10.1016/j.bbadis.2011.10.008 .

Neonatal liver failure due to deoxyguanosine kinase deficiency.

Nobre, S.; Grazina, M.; Silva, F.; Pinto, C.; Gonçalves, I.; Diogo, L., 2012. BMJ case reports. 2012. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873545510&partnerID=MN8TOARS . 10.1136/bcr.12.2011.5317 . BMJ case reports

Epigenetic engineering to reverse the Parkinson's expression state

Valente, A.X.C.N., 2012. Parkinsonism and Related Disorders. 717 - 721. 6. 18. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS . 10.1016/j.parkreldis.2012.04.018 . Parkinsonism and Related Disorders

Mitochondrial respiratory chain: Biochemical analysis and criterion for deficiency in diagnosis

Grazina, M.M., 2012. Methods in Molecular Biology. 73 - 91. 837. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856321622&partnerID=MN8TOARS . 10.1007/978-1-61779-504-6_6 . Methods in Molecular Biology

Antioxidant capacity and toxicological evaluation of Pterospartum tridentatum flower extracts

Ferreira, F.M.; Dinis, L.T.; Azedo, P.; Galhano, C.I.C.; Simões, A.; Cardoso, S.M.; Domingues, M.R.M.; et al, 2012. CYTA - Journal of Food. 92 - 102. 2. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860268444&partnerID=MN8TOARS . 10.1080/19476337.2011.590233 . CYTA - Journal of Food

Erratum: Gender-dependent metabolic remodeling during heart preservation in cardioplegic celsior and histidine buffer solution (Journal of Cardiovascular Pharmacology (2012) 59 (151-157))

Alves, M.G., 2012. Journal of Cardiovascular Pharmacology. 2. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865613134&partnerID=MN8TOARS . 10.1097/FJC.0b013e31825cce63 . Journal of Cardiovascular Pharmacology

Mitochondrial DNA 8993T>G mutation in a child with ornithine transcarbamylase deficiency and leigh syndrome: An unexpected association

Henriques, M.; Diogo, L.; Garcia, P.; Pratas, J.; Simões, M.; Grazina, M., 2012. Journal of Child Neurology. 1059 - 1061. 8. 27. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864214971&partnerID=MN8TOARS . 10.1177/0883073811431015 . Journal of Child Neurology

Exposure to dibenzofuran affects lung mitochondrial function in vitro.

Duarte FV; Simões AM; Teodoro JS; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21554085 . 10.3109/15376516.2011.576714 .

Differential effects of p,p'-DDE on testis and liver mitochondria:Implications for reproductive toxicology

Mota, P.C., 2011. Reproductive Toxicology. 80 - 85. 1. 31. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551613557&partnerID=MN8TOARS . 10.1016/j.reprotox.2010.09.010 . Reproductive Toxicology

Re-wiring the circuit: Mitochondria as a pharmacological target in liver disease

Diogo, C.V., 2011. Current Medicinal Chemistry. 5448 - 5465. 35. 18. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255173714&partnerID=MN8TOARS . 10.2174/092986711798194432 . Current Medicinal Chemistry

Assessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspective.

Teodoro JS; Simões AM; Duarte FV; Rolo AP; Murdoch RC; Hussain SM; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21232593 . 10.1016/j.tiv.2011.01.004 .

Mitochondrial tolerance to drugs and toxic agents in ageing and disease

Suski, J., 2011. Current Drug Targets. 827 - 849. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955592779&partnerID=MN8TOARS . 10.2174/138945011795529029 . Current Drug Targets

Differential sex, morphotype and tissue accumulation of mercury in the crab Carcinus maenas

Costa, S.; Viegas, I.; Pereira, E.; Duarte, A.C.; Palmeira, C.M.; Pardal, M.A., 2011. Water, Air, and Soil Pollution. 65 - 75. 1-4. 222. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80755188894&partnerID=MN8TOARS . 10.1007/s11270-011-0809-6 . Water, Air, and Soil Pollution

Mitochondria in chronic liver disease

Grattagliano, I., 2011. Current Drug Targets. 879 - 893. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955606583&partnerID=MN8TOARS . 10.2174/138945011795528877 . Current Drug Targets

Mitochondria as a drug target in health and disease

Oliveira, P.J., 2011. Current Drug Targets. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955623985&partnerID=MN8TOARS . 10.2174/138945011795528912 . Current Drug Targets

Mitochondria as a target for exercise-induced cardioprotection

Ascensão, A., 2011. Current Drug Targets. 860 - 871. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955608557&partnerID=MN8TOARS . 10.2174/138945011795529001 . Current Drug Targets

Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies

Pereira, S.L., 2011. Cardiovascular Toxicology. 180 - 190. 2. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958056642&partnerID=MN8TOARS . 10.1007/s12012-011-9112-4 . Cardiovascular Toxicology

Substrate selection in hearts subjected to ischemia/reperfusion: Role of cardioplegic solutions and gender

Alves, M.G., 2011. NMR in Biomedicine. 1029 - 1037. 9. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054064346&partnerID=MN8TOARS . 10.1002/nbm.1640 . NMR in Biomedicine

Drug-induced cardiac mitochondrial toxicity and protection: From doxorubicin to carvedilol

Pereira, G.C., 2011. Current Pharmaceutical Design. 2113 - 2129. 20. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052226370&partnerID=MN8TOARS . 10.2174/138161211796904812 . Current Pharmaceutical Design

Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study.

Nunes PM; Jones JG; Rolo AP; Palmeira CM; Carvalho RA, 2011. 2011. http://europepmc.org/abstract/med/21538633 . 10.1002/nbm.1672 .

Sodium hydrosulfide improves the protective potential of the cardioplegic histidine buffer solution

Alves, M.G., 2011. European Journal of Pharmacology. 60 - 67. 1. 654. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78951491593&partnerID=MN8TOARS . 10.1016/j.ejphar.2010.12.010 . European Journal of Pharmacology

Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen

Moreira, P.I., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology

Hepatic FXR: key regulator of whole-body energy metabolism.

Teodoro JS; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21862343 . 10.1016/j.tem.2011.07.002 .

Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity?

Monteiro, J.P., 2011. Toxicology in Vitro. 1215 - 1223. 6. 25. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960964709&partnerID=MN8TOARS . 10.1016/j.tiv.2011.05.014 . Toxicology in Vitro

Erratum: Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line (Cardiovascular Toxicology DOI: 10.1007/s12012-011-9111-5)

Branco, A.F., 2011. Cardiovascular Toxicology. 3. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054890288&partnerID=MN8TOARS . 10.1007/s12012-011-9131-1 . Cardiovascular Toxicology

Berberine as a promising safe anti-cancer agent - is there a role for mitochondria?

Diogo, C.V., 2011. Current Drug Targets. 850 - 859. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955619830&partnerID=MN8TOARS . 10.2174/138945011795528930 . Current Drug Targets

Regulation of mitochondrial biogenesis in metabolic syndrome.

Rolo AP; Gomes AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21269264 . 10.2174/138945011795529056 .

Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia

Lumini-Oliveira, J., 2011. Mitochondrion. 54 - 63. 1. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650035561&partnerID=MN8TOARS . 10.1016/j.mito.2010.07.005 . Mitochondrion

Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion

Alves, M.G., 2011. Journal of Cellular Biochemistry. 3872 - 3881. 12. 112. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055000219&partnerID=MN8TOARS . 10.1002/jcb.23320 . Journal of Cellular Biochemistry

Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: A biophysical approach with relevance to mitochondrial uncoupling

Monteiro, J.P., 2011. Journal of Bioenergetics and Biomembranes. 287 - 298. 3. 43. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959768623&partnerID=MN8TOARS . 10.1007/s10863-011-9359-2 . Journal of Bioenergetics and Biomembranes

Fatty liver and ischemia/reperfusion: are there drugs able to mitigate injury?

Varela AT; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/22050747 . 10.2174/092986711797535164 .

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells

Burgeiro, A., 2011. Anti-Cancer Drugs. 507 - 518. 6. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958289658&partnerID=MN8TOARS . 10.1097/CAD.0b013e32834438f6 . Anti-Cancer Drugs

Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats

Ascensão, A., 2011. Clinical Science. 37 - 49. 1. 120. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650871083&partnerID=MN8TOARS . 10.1042/CS20100254 . Clinical Science

Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line

Branco, A.F., 2011. Cardiovascular Toxicology. 191 - 203. 3. 11. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054914028&partnerID=MN8TOARS . 10.1007/s12012-011-9111-5 . Cardiovascular Toxicology

Bioenergetic dysfunction in Huntington's disease human cybrids

Ferreira, I. Luisa; * Cunha-Oliveira, Teresa; Nascimento, Maria V.; Ribeiro, Márcio; Proença, M. Teresa; Januário, Cristina; Oliveira, Catarina R.; Rego, A. Cristina, 2011. Experimental Neurology. 127 - 134. 1. 231. 2011. http://dx.doi.org/10.1016/j.expneurol.2011.05.024 . 10.1016/j.expneurol.2011.05.024 . published Experimental Neurology

Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells

Serafim, T.L., 2011. Chemical Research in Toxicology. 763 - 774. 5. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956157475&partnerID=MN8TOARS . 10.1021/tx200126r . Chemical Research in Toxicology

Determinação da citrulinémia após cirurgia Bariátrica ¿ Análise Preliminar / Determination of citrullinemia after bariatric surgery

Costa, BP; Serôdio, M.; Rodrigues, A; Simões, Marta; Veríssimo, C.; Grazina, Manuela; Sousa, FC, 2010. APNEP – Associação Portuguesa de Nutrição Entérica e Parentérica. 1. IV. 2010. published APNEP – Associação Portuguesa de Nutrição Entérica e Parentérica

Sub-chronic administration of doxorubicin to Wistar rats results in oxidative stress and unaltered apoptotic signaling in the lung

Machado, N.G., 2010. Chemico-Biological Interactions. 478 - 486. 3. 188. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149466319&partnerID=MN8TOARS . 10.1016/j.cbi.2010.09.027 . Chemico-Biological Interactions

Long-term hyperglycaemia decreases gastrocnemius susceptibility to permeability transition

Lumini-Oliveira, J., 2010. European Journal of Clinical Investigation. 319 - 329. 4. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949664613&partnerID=MN8TOARS . 10.1111/j.1365-2362.2010.02267.x . European Journal of Clinical Investigation

Erratum: Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death (Cardiovascular Toxicology (2010) 10 (51-65) DOI:10.1007/s12012-010-9062-2)

Silva, J.P., 2010. Cardiovascular Toxicology. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956395509&partnerID=MN8TOARS . 10.1007/s12012-010-9067-x . Cardiovascular Toxicology

Electrochemical oxidation of sanguinarine and of its oxidation products at a glassy carbon electrode - relevance to intracellular effects

Diculescu, V.C., 2010. Electroanalysis. 113 - 120. 1. 22. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-72649099240&partnerID=MN8TOARS . 10.1002/elan.200900367 . Electroanalysis

Dimethylaminopyridine derivatives of lupane triterpenoids are potent disruptors of mitochondrial structure and function

Holy, J., 2010. Bioorganic and Medicinal Chemistry. 6080 - 6088. 16. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955472585&partnerID=MN8TOARS . 10.1016/j.bmc.2010.06.075 . Bioorganic and Medicinal Chemistry

Mg2+-doped poly(epsilon-caprolactone)/siloxane biohybrids

Teixeira, J. C. S.; Fernandes, M.; Bermudez, V. de Zea; Barbosa, P. C.; Rodrigues, L. C.; Silva, M. M.; Smith, M. J., 2010. Electrochimica Acta. 1328 - 1332. 4. 55. 2010. 10.1016/j.electacta.2009.06.024 . published Electrochimica Acta

Biapigenin modulates the activity of the adenine nucleotide translocator in isolated rat brain mitochondria

Silva, B.A., 2010. Neurotoxicity Research. 75 - 90. 1. 17. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77449110345&partnerID=MN8TOARS . 10.1007/s12640-009-9082-5 . Neurotoxicity Research

Nitrogen compounds prevent h9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death.

Silva JP; Sardão VA; Coutinho OP; Oliveira PJ; Olveira PJ, 2010. 2010. http://europepmc.org/abstract/med/20119745 . 10.1007/s12012-010-9062-2 .

Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics.

Simões AM; Duarte FV; Teodoro JS; Rolo AP; Palmeira CM, 2010. 2010. http://europepmc.org/abstract/med/20158383 . 10.3109/15376510903527916 .

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Hafner, A.V.; Dai, J.; Gomes, A.P.; Xiao, C.-Y.; Palmeira, K.C.M.; Rosenzweig, A.; Sinclair, D.A.; et al, 2010. Aging. 914 - 923. 12. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952266729&partnerID=MN8TOARS . Aging

Value of Brain Magnetic Resonance Imaging in Mitochondrial Respiratory Chain Disorders

Diogo, L.; Cordeiro, M.; Garcia, P.; Fineza, I.; Moura, C.; Oliveira, C.R.; Veiga, M.; Garcia, T.; Grazina, M., 2010. Pediatric Neurology. 196 - 200. 3. 42. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249116575&partnerID=MN8TOARS . 10.1016/j.pediatrneurol.2009.09.010 . Pediatric Neurology

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, 2010. Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.

Carvalho RA; Sousa RP; Cadete VJ; Lopaschuk GD; Palmeira CM; Bjork JA; Wallace KB, 2010. 2010. http://europepmc.org/abstract/med/20132857 . 10.1016/j.tox.2010.01.019 .

Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3beta and mitochondrial permeability transition.

Varela AT; Simões AM; Teodoro JS; Duarte FV; Gomes AP; Palmeira CM; Rolo AP, 2010. 2010. http://europepmc.org/abstract/med/20433952 . 10.1016/j.mito.2010.04.006 .

Neurotoxicity of heroin-cocaine combinations in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., 2010. Toxicology. 11 - 17. 1. 276. 2010. http://dx.doi.org/10.1016/j.tox.2010.06.009 . 10.1016/j.tox.2010.06.009 . published Toxicology

Mitochondrial preservation in celsior versus histidine buffer solution during cardiac Ischemia and reperfusion

Alves, M.G., 2009. Cardiovascular Toxicology. 185 - 193. 4. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-71949090655&partnerID=MN8TOARS . 10.1007/s12012-009-9052-4 . Cardiovascular Toxicology

Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety?

Pereira, C.V., 2009. Current Drug Safety. 34 - 54. 1. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-63249131066&partnerID=MN8TOARS . 10.2174/157488609787354440 . Current Drug Safety

Parabens in male infertility-Is there a mitochondrial connection?

Tavares, R.S., 2009. Reproductive Toxicology. 1 - 7. 1. 27. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749116602&partnerID=MN8TOARS . 10.1016/j.reprotox.2008.10.002 . Reproductive Toxicology

Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts

Sardão, V.A., 2009. Cancer Chemotherapy and Pharmacology. 811 - 827. 4. 64. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169047&partnerID=MN8TOARS . 10.1007/s00280-009-0932-x . Cancer Chemotherapy and Pharmacology

Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats

Amaral, S., 2009. Mitochondrion. 41 - 50. 1. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60249101037&partnerID=MN8TOARS . 10.1016/j.mito.2008.11.005 . Mitochondrion

Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-A model for endangered species

Mota, P., 2009. Reproductive Toxicology. 111 - 116. 2. 27. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549148154&partnerID=MN8TOARS . 10.1016/j.reprotox.2009.01.008 . Reproductive Toxicology

Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?

Pereira, S.P.; Pereira SP; Pereira GC; Moreno AJ; Oliveira PJ, 2009. ATLA Alternatives to Laboratory Animals. 355 - 365. 4. 37. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449604749&partnerID=MN8TOARS . ATLA Alternatives to Laboratory Animals

Doxorubicin: The good, the bad and the ugly effect

Carvalho, C., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets

Sardão, V.A., 2009. Cell Biology and Toxicology. 227 - 243. 3. 25. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349167673&partnerID=MN8TOARS . 10.1007/s10565-008-9070-1 . Cell Biology and Toxicology

Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin - Relevance for possible anti-cancer application

Diogo, C.V., 2009. Toxicology in Vitro. 772 - 779. 5. 23. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649401716&partnerID=MN8TOARS . 10.1016/j.tiv.2009.04.002 . Toxicology in Vitro

Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.

Rolo AP; Palmeira CM; Cortopassi GA, 2009. 2009. http://europepmc.org/abstract/med/18950600 . 10.1016/j.ab.2008.10.002 .

Electrochemical oxidation of berberine and of its oxidation products at a glassy carbon electrode

Diculescu, V.C., 2009. Electroanalysis. 1027 - 1034. 9. 21. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66649083195&partnerID=MN8TOARS . 10.1002/elan.200804516 . Electroanalysis

Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition.

Rolo AP; Teodoro JS; Peralta C; Rosello-Catafau J; Palmeira CM, 2009. 2009. http://europepmc.org/abstract/med/19619169 . 10.1111/j.1432-2277.2009.00916.x .

The brain-heart connection in mitochondrial respiratory chain diseases.

Cordeiro M; Scaglia F; Lopes Da Silva S; Garcia P; Grazina M; Moura C; Diogol L; et al, 2009. Neuroradiology Journal. 558 - 563. 5. 22. 2009. http://europepmc.org/abstract/med/24209401 . 10.1177/197140090902200508 . Neuroradiology Journal

Pediatric Mitochondrial Respiratory Chain Disorders in the Centro Region of Portugal

Diogo, L.; Grazina, M.; Garcia, P.; Rebelo, O.; Veiga, M.A.; Cuevas, J.; Vilarinho, L.; de Almeida, I.T.; Oliveira, C.R., 2009. Pediatric Neurology. 351 - 356. 5. 40. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64549161480&partnerID=MN8TOARS . 10.1016/j.pediatrneurol.2008.11.012 . Pediatric Neurology

Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF

Almeida, Sandra; Cunha-Oliveira, Teresa; Laço, Mário; Oliveira, Catarina R.; Rego, A. Cristina, 2009. Neurotoxicity Research. 399 - 405. 4. 17. 2009. http://dx.doi.org/10.1007/s12640-009-9116-z . 10.1007/s12640-009-9116-z . published Neurotoxicity Research

BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons

Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C., 2009. Neurobiology of Disease. 448 - 456. 3. 35. 2009. http://dx.doi.org/10.1016/j.nbd.2009.06.006 . 10.1016/j.nbd.2009.06.006 . published Neurobiology of Disease

Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box?

Machado NG; Alves MG; Carvalho RA; Oliveira PJ, 2009. 2009. http://europepmc.org/abstract/med/19855945 . 10.1007/s12012-009-9055-1 .

Endurance training improves gastrocnemius mitochondrial function despite increased susceptibility to permeability transition

Lumini-Oliveira, J., 2009. Mitochondrion. 454 - 462. 6. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449133441&partnerID=MN8TOARS . 10.1016/j.mito.2009.08.005 . Mitochondrion

Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction.

Varela AT; Gomes AP; Simões AM; Teodoro JS; Duarte FV; Rolo AP; Palmeira CM, 2008. 2008. http://europepmc.org/abstract/med/18786556 . 10.1016/j.taap.2008.08.005 .

Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13C]bicarbonate and [1-13C]lactate.

Alves TC; Nunes PM; Palmeira CM; Jones JG; Carvalho RA, 2008. 2008. http://europepmc.org/abstract/med/17683055 . 10.1002/nbm.1195 .

Quercetin, kaempferol and biapigenin from hypericum perforatum are neuroprotective against excitotoxic insults

Silva, B., 2008. Neurotoxicity Research. 265 - 279. 3-4. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55249095521&partnerID=MN8TOARS . 10.1007/BF03033510 . Neurotoxicity Research

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, S., 2008. Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.08.008 . Free Radical Biology and Medicine

Disruption of hepatic mitochondrial bioenergetics is not a primary mechanism for the toxicity of methoprene - relevance for toxicological assessment.

Monteiro JP; Oliveira PJ; Moreno AJ; Jurado AS, 2008. 2008. http://europepmc.org/abstract/med/18511104 . 10.1016/j.chemosphere.2008.04.024 .

Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury.

Sardão VA; Pereira SL; Oliveira PJ, 2008. 2008. http://europepmc.org/abstract/med/18324876 . 10.1517/14740338.7.2.129 .

Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression.

Teodoro JS; Rolo AP; Duarte FV; Simões AM; Palmeira CM, 2008. 2008. http://europepmc.org/abstract/med/18765303 . 10.1016/j.mito.2008.07.008 .

Mitochondria a key role in microcystin-LR kidney intoxication.

La-Salete R; Oliveira MM; Palmeira CA; Almeida J; Peixoto FP, 2008. 2008. http://europepmc.org/abstract/med/17461434 . 10.1002/jat.1251 .

Evaluation of olive oil mill wastewater toxicity on the mitochondrial bioenergetics after treatment with Candida oleophila

Peixoto, F.; Martins, F.; Amaral, C.; Gomes-Laranjo, J.; Almeida, J.; Palmeira, C.M., 2008. Ecotoxicology and Environmental Safety. 266 - 275. 2. 70. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049108014&partnerID=MN8TOARS . 10.1016/j.ecoenv.2007.11.003 . Ecotoxicology and Environmental Safety

Inhibition of the adenine nucleotide translocator by N-acetyl perfluorooctane sulfonamides in vitro

O'Brien, T.M., 2008. Toxicology and Applied Pharmacology. 184 - 195. 2. 227. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949127988&partnerID=MN8TOARS . 10.1016/j.taap.2007.10.016 . Toxicology and Applied Pharmacology

Mechanisms of berberine (Natural Yellow 18) - Induced mitochondrial dysfunction: Interaction with the adenine nucleotide translocator

Pereira, C.V., 2008. Toxicological Sciences. 408 - 417. 2. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849122083&partnerID=MN8TOARS . 10.1093/toxsci/kfn131 . Toxicological Sciences

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Oliveira, Catarina R., 2008. Brain Research Reviews. 192 - 208. 1. 58. 2008. http://dx.doi.org/10.1016/j.brainresrev.2008.03.002 . 10.1016/j.brainresrev.2008.03.002 . Brain Research Reviews

Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells-Nuclear vs. mitochondrial effects

Serafim, T.L., 2008. Biochemical Pharmacology. 1459 - 1475. 11. 76. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949119796&partnerID=MN8TOARS . 10.1016/j.bcp.2008.07.013 . Biochemical Pharmacology

Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line

Serafim, T.L., 2008. Cancer Chemotherapy and Pharmacology. 1007 - 1018. 6. 61. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41049098849&partnerID=MN8TOARS . 10.1007/s00280-007-0558-9 . Cancer Chemotherapy and Pharmacology

Diabetes and the impairment of reproductive function: Possible role of mitochondria and reactive oxygen species

Amaral, S., 2008. Current Diabetes Reviews. 46 - 54. 1. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949101210&partnerID=MN8TOARS . 10.2174/157339908783502398 . Current Diabetes Reviews

Complex formation between heptakis(2,6-di-O-methyl)-ß-cyclodextrin and cyclopentadienyl molybdenum(II) dicarbonyl complexes: Structural studies and cytotoxicity evaluations

Pereira, C.C.L., 2008. Organometallics. 4948 - 4956. 19. 27. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249115357&partnerID=MN8TOARS . 10.1021/om800413w . Organometallics

Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

Amaral, S., 2008. FEBS Letters. 4191 - 4196. 30. 582. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649108974&partnerID=MN8TOARS . 10.1016/j.febslet.2008.11.020 . FEBS Letters

Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus

Lumini, J.A., 2008. Sports Medicine. 735 - 750. 9. 38. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49949103399&partnerID=MN8TOARS . 10.2165/00007256-200838090-00003 . Sports Medicine

Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: Comparison with direct effects on isolated mitochondrial fractions

Pereira, G.C., 2007. Journal of Pharmacology and Experimental Therapeutics. 636 - 649. 2. 323. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548974344&partnerID=MN8TOARS . 10.1124/jpet.107.128017 . Journal of Pharmacology and Experimental Therapeutics

Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis.

Palmeira CM; Rolo AP; Berthiaume J; Bjork JA; Wallace KB, 2007. 2007. http://europepmc.org/abstract/med/17761203 . 10.1016/j.taap.2007.07.015 .

Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide - Characterization of morphological features of cell death

Sardão, V.A., 2007. BMC Cell Biology. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947598915&partnerID=MN8TOARS . 10.1186/1471-2121-8-11 . BMC Cell Biology

Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle

Magalhães, J., 2007. Clinical Science. 459 - 466. 11-12. 113. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849067904&partnerID=MN8TOARS . 10.1042/CS20070075 . Clinical Science

Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., 2007. Journal of Neurochemistry. 543 - 554. 2. 101. 2007. http://dx.doi.org/10.1111/j.1471-4159.2006.04406.x . 10.1111/j.1471-4159.2006.04406.x . Journal of Neurochemistry

Atypical presentation of Leber's hereditary optic neuropathy associated to mtDNA 11778G>A point mutation-A case report

Grazina, M.M.; Diogo, L.M.; Garcia, P.C.; Silva, E.D.; Garcia, T.D.; Robalo, C.B.; Oliveira, C.R., 2007. European Journal of Paediatric Neurology. 115 - 118. 2. 11. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847234224&partnerID=MN8TOARS . 10.1016/j.ejpn.2006.11.015 . European Journal of Paediatric Neurology

Inhibition of mitochondrial bioenergetics by carbaryl is only evident for higher concentrations - Relevance for carbaryl toxicity mechanisms

Moreno, A.J.M., 2007. Chemosphere. 404 - 411. 3. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751232011&partnerID=MN8TOARS . 10.1016/j.chemosphere.2006.06.030 . Chemosphere

Mitochondria as targets for neuronal protection against excitotoxicity: A role for phenolic compounds?

Silva, B.A., 2007. Central Nervous System Agents in Medicinal Chemistry. 205 - 222. 3. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548408654&partnerID=MN8TOARS . 10.2174/187152407781669152 . Central Nervous System Agents in Medicinal Chemistry

Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine

Cunha-Oliveira, T; Rego, AC; Macedo, T; Oliveira, CR, 2007. Free Radical Research. S22 - S22. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300068&KeyUID=WOS:000252296300068 . Free Radical Research

Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in Wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization

Moreno, A.J., 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247399590&partnerID=MN8TOARS . 10.1002/jbt.20159 . Journal of Biochemical and Molecular Toxicology

Response [2]

Oliveira, P.J., 2007. Journal of Biochemical and Molecular Toxicology. 6. 21. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749085079&partnerID=MN8TOARS . 10:1002/jbt . Journal of Biochemical and Molecular Toxicology

Efeito crónico da heroína e do peróxido de hidrogénio em células PC12

Cunha-Oliveira, Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina R, 2006. Coimbra Médica V. 21 - 29. 1. 2. 2006. http://hdl.handle.net/10316/18520 . published Coimbra Médica V

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

Rolo AP; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/16490224 . 10.1016/j.taap.2006.01.003 .

Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: No association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene

Correia, C.; Coutinho, A.M.; Diogo, L.; Grazina, M.; Marques, C.; Miguel, T.; Ataíde, A.; et al, 2006. Journal of Autism and Developmental Disorders. 1137 - 1140. 8. 36. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845912666&partnerID=MN8TOARS . 10.1007/s10803-006-0138-6 . Journal of Autism and Developmental Disorders

Genetic basis of Alzheimer's dementia: Role of mtDNA mutations

Grazina, M.; Pratas, J.; Silva, F.; Oliveira, S.; Santana, I.; Oliveira, C., 2006. Genes, Brain and Behavior. 92 - 107. SUPPL. 2. 5. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646236099&partnerID=MN8TOARS . 10.1111/j.1601-183X.2006.00225.x . Genes, Brain and Behavior

Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis.

Teodoro J; Rolo AP; Oliveira PJ; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/16554051 . 10.1016/j.febslet.2006.02.078 .

Endurance training limits the functional alterations of heart rat mitochondria submitted to in vitro anoxia-reoxygenation

Ascensão, A., 2006. International Journal of Cardiology. 169 - 178. 2. 109. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646109584&partnerID=MN8TOARS . 10.1016/j.ijcard.2005.06.003 . International Journal of Cardiology

Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende, 2006. Toxicology. 54 - 62. 1. 217. 2006. http://dx.doi.org/10.1016/j.tox.2005.08.022 . 10.1016/j.tox.2005.08.022 . Toxicology

Effects of endurance training and acute doxorubicin treatment on rat heart mitochondrial alterations induced by in vitro anoxia-reoxygenation

Ascensão, A.; Ascensão A; Ferreira R; Oliveira PJ; Magalhães J, 2006. Cardiovascular Toxicology. 159 - 171. 3-4. 6. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947101036&partnerID=MN8TOARS . 10.1385/ct:6:3:159 . Cardiovascular Toxicology

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://dx.doi.org/10.1016/j.brainres.2006.03.061 . 10.1016/j.brainres.2006.03.061 . published Brain Research

Esterification prevents induction of the mitochondrial permeability transition by N-acetyl perfluorooctane sulfonamides

O'Brien, T.M., 2006. Chemical Research in Toxicology. 1305 - 1312. 10. 19. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209492&partnerID=MN8TOARS . 10.1021/tx060132r . Chemical Research in Toxicology

Pt(II) vs Pd(II) polyamine complexes as new anticancer drugs: A structure-activity study

Fiuza, S.M., 2006. Letters in Drug Design and Discovery. 149 - 151. 3. 3. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645876182&partnerID=MN8TOARS . 10.2174/157018006776286989 . Letters in Drug Design and Discovery

Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis

Teodoro, J., 2006. FEBS Letters. 2153 - 2157. 8. 580. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645241135&partnerID=MN8TOARS . 10.1016/j.febslet.2006.02.078 . FEBS Letters

Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats - Relevance for mitochondrial dysfunction

Oliveira, P.J., 2006. Toxicology. 160 - 168. 2-3. 220. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33244492919&partnerID=MN8TOARS . 10.1016/j.tox.2005.12.009 . Toxicology

Doxorubicin-induced thiol-dependent alteration of cardiac mitochondrial permeability transition and respiration

Oliveira, P.J., 2006. Biochemistry (Moscow). 194 - 199. 2. 71. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645277082&partnerID=MN8TOARS . 10.1134/S000629790602012X . Biochemistry (Moscow)

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship

Milhazes, N.; Cunha-Oliveira, T.; Martins, P.; Garrido, J.; Oliveira, C.; Rego, A.C.; Borges, F., 2006. Chemical Research in Toxicology. 1294 - 1304. 10. 19. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209029&partnerID=MN8TOARS . 10.1021/tx060123i . Chemical Research in Toxicology

Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the Diabetic Goto-Kakizaki (GK) Rat as a Model.

Ferreira FM; Moreno AJ; Seiça R; Santos MS; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/20021031 . 10.1080/15376520600616925 .

Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells

Domingues, A.; * Oliveira, T.C.; Laço, M.L.N.; Macedo, T.R.A.; Oliveira, C.R.; Rego, A.C., 2006. Annals of the New York Academy of Sciences. 458 - 465. 1074. 2006. http://dx.doi.org/10.1196/annals.1369.046 . 10.1196/annals.1369.046 . published Annals of the New York Academy of Sciences

Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?

Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.; Ferreira M; Coxito PM; et al, 2005. Cardiovascular Toxicology. 63 - 73. 1. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544374442&partnerID=MN8TOARS . 10.1385/CT:5:1:063 . Cardiovascular Toxicology

Mitochondrial function is not affected by renal morphological changes in diabetic goto-kakizaki rat.

Seiça R; Santos DL; Palmeira CM; Moreno AJ; Sena C; Cunha MF; Santos MS, 2005. 2005. http://europepmc.org/abstract/med/20021090 . 10.1080/15376520590968806 .

Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria?

Oliveira, P.J., 2005. Current Vascular Pharmacology. 147 - 158. 2. 3. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144430946&partnerID=MN8TOARS . 10.2174/1570161053586903 . Current Vascular Pharmacology

Mitochondrial DNA variants in a Portuguese population of patients with Alzheimer's disease

Grazina, M.; Silva, F.; Santana, I.; Pratas, J.; Santiago, B.; Oliveira, M.; Carreira, I.; Cunha, L.; Oliveira, C., 2005. European Neurology. 121 - 124. 3. 53. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20844462230&partnerID=MN8TOARS . 10.1159/000085555 . European Neurology

Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis

Ascensão, A., 2005. American Journal of Physiology - Heart and Circulatory Physiology. 2 58-2. 289. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744489541&partnerID=MN8TOARS . 10.1152/ajpheart.01249.2004 . American Journal of Physiology - Heart and Circulatory Physiology

Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?

Ferreira M; Coxito PM; Sardão VA; Palmeira CM; Oliveira PJ; Ferreira, M., 2005. Cardiovascular toxicology. 63 - 73. 1. 5. 2005. http://europepmc.org/abstract/med/15738586 . 10.1385/ct:5:1:063 . Cardiovascular toxicology

Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction

Berthiaume, J.M., 2005. Cardiovascular Toxicology. 257 - 267. 3. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144450968&partnerID=MN8TOARS . 10.1385/CT:5:3:257 . Cardiovascular Toxicology

Cardiac mitochondrial alterations observed in hyperglycaemic rats--what can we learn from cell biology?

Oliveira PJ; Oliveira, P.J., 2005. Current diabetes reviews. 11 - 21. 1. 1. 2005. http://europepmc.org/abstract/med/18220578 . 10.2174/1573399052952578 . Current diabetes reviews

Mitochondrial dysfunction in autism spectrum disorders: A population-based study

Oliveira, G.; Diogo, L.; Grazina, M.; Garcia, P.; Ataíde, A.; Marques, C.; Miguel, T.; et al, 2005. Developmental Medicine and Child Neurology. 185 - 189. 3. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14044258489&partnerID=MN8TOARS . 10.1017/S0012162205000332 . Developmental Medicine and Child Neurology

Frontotemporal dementia and mitochondrial DNA transitions

Grazina, M.; Silva, F.; Santana, I.; Santiago, B.; Mendes, C.; Simões, M.; Oliveira, M.; Cunha, L.; Oliveira, C., 2004. Neurobiology of Disease. 306 - 311. 2. 15. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542300730&partnerID=MN8TOARS . 10.1016/j.nbd.2003.11.004 . Neurobiology of Disease

Mitochondrially-mediated toxicity of bile acids.

Palmeira CM; Rolo AP, 2004. 2004. http://europepmc.org/abstract/med/15363577 . 10.1016/j.tox.2004.06.001 .

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats.

Oliveira PJ; Seica R; Santos DL; Rolo AP; Sardao VA; Ferreira FM; Palmeira CM; Santos MS; Moreno AJ, 2004. 2004. http://europepmc.org/abstract/med/16120365 . 10.1016/j.mito.2004.02.005 .

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.

Oliveira PJ; Rolo AP; Sardão VA; Monteiro P; Gonçalves L; Providência LA; Palmeira CM; et al, 2004. Revista Portuguesa de Cardiologia. 1291 - 1298. 10. 23. 2004. http://europepmc.org/abstract/med/15641294 . Revista Portuguesa de Cardiologia

Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism.

Oliveira PJ; Esteves T; Rolo AP; Palmeira CM; Moreno AJ, 2004. 2004. http://europepmc.org/abstract/med/15034201 . 10.1385/CT:4:1:11 .

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.

Oliveira PJ; Rolo AP; Sardão VA; Monteiro P; Gonçalves L; Providência LA; Palmeira CM; Moreno AJ; Oliveira, P.J., 2004. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 1291 - 1298. 10. 23. 2004. http://europepmc.org/abstract/med/15641294 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

Rolo AP; Palmeira CM; Holy JM; Wallace KB, 2004. 2004. http://europepmc.org/abstract/med/14976352 . 10.1093/toxsci/kfh078 .

Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity

Oliveira, P.J., 2004. Toxicology and Applied Pharmacology. 159 - 168. 2. 200. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-5144227343&partnerID=MN8TOARS . 10.1016/j.taap.2004.04.005 . Toxicology and Applied Pharmacology

Carvedilol Inhibits the Mitochondrial Permeability Transition by an Antioxidant Mechanism

Oliveira, P.J., 2004. Cardiovascular Toxicology. 11 - 20. 1. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942486470&partnerID=MN8TOARS . 10.1385/CT:4:1:11 . Cardiovascular Toxicology

Calcium-dependent mitochondrial permeability transition is augmented in the kidney of Goto-Kakizaki diabetic rat

Oliveira, P.J., 2004. Diabetes/Metabolism Research and Reviews. 131 - 136. 2. 20. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842853998&partnerID=MN8TOARS . 10.1002/dmrr.423 . Diabetes/Metabolism Research and Reviews

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats

Oliveira, P.J., 2004. Mitochondrion. 337 - 345. 6. 3. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484378&partnerID=MN8TOARS . 10.1016/j.mito.2004.02.005 . Mitochondrion

Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC

Rolo, A.P., 2003. Hepatology Research. 217 - 224. 3. 26. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042167601&partnerID=MN8TOARS . 10.1016/S1386-6346(03)00108-6 . Hepatology Research

Reduction in cardiac mitochondrial calcium loading capacity is observable during a-naphthylisothiocyanate-induced acute cholestasis: A clue for hepatic-derived cardiomyopathies?

Oliveira, P.J., 2003. Biochimica et Biophysica Acta - Molecular Basis of Disease. 39 - 45. 1. 1637. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037454702&partnerID=MN8TOARS . 10.1016/S0925-4439(02)00212-0 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease? | Colestase crónica e funçá~o mitocondrial cardíaca em ratos wistar: Um modelo para alterações cardiovasculares no contexto de doenças hepáticas crónicas?

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J., 2003. Revista Portuguesa de Cardiologia. 67 - 75. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chenodexycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: Protective role of carvedilol

Rolo, A.P., 2003. Mitochondrion. 305 - 311. 4. 2. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037347309&partnerID=MN8TOARS . 10.1016/S1567-7249(03)00007-2 . Mitochondrion

Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2003. 2003. http://europepmc.org/abstract/med/12850694 . 10.1016/S1386-6346(03)00108-6 .

Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease? | Colestase crónica e funçá~o mitocondrial cardíaca em ratos wistar: Um modelo para alterações cardiovasculares no contexto de doenças hepáticas crónicas?

Oliveira, P.J., 2003. Revista Portuguesa de Cardiologia. 67 - 75. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Diabetes induces metabolic adaptations in rat liver mitochondria: Role of coenzyme Q and cardiolipin contents

Ferreira, F.M., 2003. Biochimica et Biophysica Acta - Molecular Basis of Disease. 113 - 120. 2. 1639. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0642345079&partnerID=MN8TOARS . 10.1016/j.bbadis.2003.08.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats

Oliveira, P.J., 2003. FEBS Letters. 511 - 514. 3. 554. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242541631&partnerID=MN8TOARS . 10.1016/S0014-5793(03)01233-X . FEBS Letters

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with a-naphthyl-isothiocyanate (ANIT)

Palmeira, C.M., 2003. Toxicology. 185 - 196. 3. 190. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042133192&partnerID=MN8TOARS . 10.1016/S0300-483X(03)00163-X . Toxicology

Mitochondria: Role in ischemia, reperfusion and cell death | Mitocôndrias: Que papel na isquémia, reperfusão e morte celular?

Monteiro, P., 2003. Revista Portuguesa de Cardiologia. 233 - 254. 2. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037732545&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition | Carvedilol: Relação entre a actividade antioxidante e inibição da transição de permeabilidade mitocondrial

Oliveira, P.J.; Esteves, T.; Rolo, A.P.; Monteiro, P.; Gonçalves, L.; Palmeira, C.M.; Moreno, A.J., 2003. Revista Portuguesa de Cardiologia. 55 - 62. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats

Oliveira, P.J.; Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. Journal of Investigative Medicine. 86 - 94. 2. 51. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037338705&partnerID=MN8TOARS . Journal of Investigative Medicine

Pharmacological modulation of mitochondrial function during ischemia and reperfusion | Modulação farmacológica da função mitocondrial no contexto da isquemia e reperfusão

Monteiro, P., 2003. Revista Portuguesa de Cardiologia. 407 - 429. 3. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038795126&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12712811 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition | Carvedilol: Relação entre a actividade antioxidante e inibição da transição de permeabilidade mitocondrial

Oliveira, P.J., 2003. Revista Portuguesa de Cardiologia. 55 - 62. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Carvedilol: relation between antioxidant activity and inhibition of the mitochondrial permeability transition.

Oliveira PJ; Esteves T; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12712810 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Mitochondria: role in ischemia, reperfusion and cell death.

Monteiro P; Oliveira PJ; Gonçalves L; Providência LA, 2003. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2003. http://europepmc.org/abstract/med/12769003 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.

Ferreira FM; Oliveira PJ; Rolo AP; Santos MS; Moreno AJ; da Cunha MF; Seiça R; Palmeira CM; Ferreira, F.M., 2003. Archives of Toxicology. 194 - 200. 4. 77. 2003. http://europepmc.org/abstract/med/12698234 . Archives of Toxicology

Parkinson's disease and mitochondrial DNA NADH dehydrogenase subunit 1 nucleotides 3337-3340: Study in a population from the central region of Portugal (Coimbra)

Grazina, M.; Silva, F.; Januário, C.; Oliveira, M.; Cunha, L.; Oliveira, C., 2003. European Neurology. 60 - 61. 1. 50. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038307365&partnerID=MN8TOARS . 10.1159/000070863 . European Neurology

Drugs of abuse induce apoptotic features in PC12 cells

Cunha-Oliveira, T.; Rego, A.C.; Macedo, T.; Oliveira, C.R., 2003. Annals of the New York Academy of Sciences. 667 - 670. 1. 1010. 2003. http://dx.doi.org/10.1196/annals.1299.121 . 10.1196/annals.1299.121 . published Annals of the New York Academy of Sciences

Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2003. 2003. http://europepmc.org/abstract/med/16120330 . 10.1016/S1567-7249(03)00007-2 .

Carvedilol: relation between antioxidant activity and inhibition of the mitochondrial permeability transition.

Oliveira PJ; Esteves T; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12712810 .

Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12527405 . 10.1016/S0925-4439(02)00212-0 .

Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents.

Ferreira FM; Seiça R; Oliveira PJ; Coxito PM; Moreno AJ; Palmeira CM; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/14559118 . 10.1016/j.bbadis.2003.08.001 .

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).

Palmeira CM; Ferreira FM; Rolo AP; Oliveira PJ; Santos MS; Moreno AJ; Cipriano MA; Martins MI; Seiça R, 2003. 2003. http://europepmc.org/abstract/med/12927374 . 10.1016/S0300-483X(03)00163-X .

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats.

Oliveira PJ; Seiça R; Coxito PM; Rolo AP; Palmeira CM; Santos MS; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/14623121 . 10.1016/S0014-5793(03)01233-X .

Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12712811 .

Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.

Ferreira FM; Oliveira PJ; Rolo AP; Santos MS; Moreno AJ; da Cunha MF; Seiça R; et al, 2003. Archives of Toxicology. 194 - 200. 4. 77. 2003. http://europepmc.org/abstract/med/12698234 . 10.1007/s00204-003-0441-3 . Archives of Toxicology

Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.

Santos DL; Palmeira CM; Seiça R; Dias J; Mesquita J; Moreno AJ; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/12841358 . 10.1023/A:1023475022025 .

Diabetes and mitochondrial bioenergetics: alterations with age.

Ferreira FM; Palmeira CM; Seiça R; Moreno AJ; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/12898645 . 10.1002/jbt.10081 .

Mitochondrially mediated synergistic cell killing by bile acids.

Rolo AP; Palmeira CM; Wallace KB, 2003. 2003. http://europepmc.org/abstract/med/12527417 . 10.1016/S0925-4439(02)00224-7 .

Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ; Oliveira, P.J.; et al, 2003. Journal of Investigative Medicine. 86 - 94. 2. 51. 2003. http://europepmc.org/abstract/med/12643513 . Journal of Investigative Medicine

Impact of diabetes on induction of the mitochondrial permeability transition.

Oliveira PJ; Rolo AP; Seiça R; Sardão V; Monteiro P; Gonçalves L; Providência L; et al, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 759 - 766. 6. 21. 2002. http://europepmc.org/abstract/med/12194377 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Study of carvedilol by combined Raman spectroscopy and ab initio MO calculations

Marques, M.P.M., 2002. Journal of Raman Spectroscopy. 778 - 783. 10. 33. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036773098&partnerID=MN8TOARS . 10.1002/jrs.916 . Journal of Raman Spectroscopy

Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis

Rolo, A.P.; Rolo AP; Oliveira PJ; Seiça R; Santos MS; Moreno AJ; Palmeira CM, 2002. Journal of Investigative Medicine. 193 - 200. 3. 50. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS . Journal of Investigative Medicine

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase--what role in myocardial ischemia and reperfusion?

Oliveira PJ; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2002. 2002. http://europepmc.org/abstract/med/12621918 .

Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism.

Rolo AP; Palmeira CM; Wallace KB, 2002. 2002. http://europepmc.org/abstract/med/11814708 . 10.1016/S0378-4274(01)00464-7 .

Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis

Rolo, A.P.; Oliveira, P.J.; Seiça, R.; Santos, M.S.; Moreno, A.J.; Palmeira, C.M.; Rolo AP; et al, 2002. Journal of Investigative Medicine. 193 - 200. 3. 50. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS . Journal of Investigative Medicine

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion? | Impacto do carvedilol sobre o dano mitocondrial induzido por hipoxantina/xantina oxidase - Que papel na isquemia e reperfusão do miocárdio?

Oliveira, P.J.; Rolo, A.P.; Monteiro, P.; Conçalves, L.; Palmeira, C.M.; Moreno, A.J., 2002. Revista Portuguesa de Cardiologia. 1447 - 1455. 12. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.

Rolo AP; Oliveira PJ; Seiça R; Santos MS; Moreno AJ; Palmeira CM, 2002. 2002. http://europepmc.org/abstract/med/12127259 . 10.1006/taap.2002.9434 .

Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: Relevance for caffeine toxicity

Sardão, V.A., 2002. Toxicology and Applied Pharmacology. 50 - 56. 1. 179. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037082662&partnerID=MN8TOARS . 10.1006/taap.2001.9334 . Toxicology and Applied Pharmacology

Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells

# Cunha-Oliveira, T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.R.A.; Oliveira, C.R., 2002. Annals of the New York Academy of Sciences. 487 - 496. 965. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036290212&partnerID=MN8TOARS . 10.1111/j.1749-6632.2002.tb04190.x . published Annals of the New York Academy of Sciences

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion? | Impacto do carvedilol sobre o dano mitocondrial induzido por hipoxantina/xantina oxidase - Que papel na isquemia e reperfusão do miocárdio?

Oliveira, P.J., 2002. Revista Portuguesa de Cardiologia. 1447 - 1455. 12. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase--what role in myocardial ischemia and reperfusion?

Oliveira PJ; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2002. http://europepmc.org/abstract/med/12621918 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of a-naphthylisothiocyanate

Rolo, A.P., 2002. Toxicology and Applied Pharmacology. 20 - 26. 1. 182. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036070550&partnerID=MN8TOARS . 10.1006/taap.2002.9434 . Toxicology and Applied Pharmacology

Impact of diabetes on induction of the mitochondrial permeability transition.

Oliveira PJ; Rolo AP; Seiça R; Sardão V; Monteiro P; Gonçalves L; Providência L; et al, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 759 - 766. 6. 21. 2002. http://europepmc.org/abstract/med/12194377 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2001. Bioscience Reports. 73 - 80. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS . 10.1023/A:1010438202519 . Bioscience Reports

Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2001. Biochemical Pharmacology. 1449 - 1454. 11. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00620-7 . Biochemical Pharmacology

Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore

Oliveira, P.J., 2001. European Journal of Pharmacology. 231 - 237. 3. 412. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS . 10.1016/S0014-2999(01)00745-2 . European Journal of Pharmacology

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate

Oliveira, P.J.; Oliveira PJ; Rolo AP; Seiça R; Palmeira CM; Santos MS; Moreno AJ, 2001. Bioscience Reports. 45 - 53. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034905572&partnerID=MN8TOARS . 10.1023/a:1010482017540 . Bioscience Reports

Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: Role of coenzyme Q

Palmeira, C.M.; Santos, D.L.; Seiça, R.; Moreno, A.J.; Santos, M.S.; Palmeira CM; Santos DL; et al, 2001. American Journal of Physiology - Cell Physiology. 3 50-3. 281. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034838234&partnerID=MN8TOARS . American Journal of Physiology - Cell Physiology

Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

Rolo, A.P., 2001. Bioscience Reports. 73 - 80. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS . 10.1023/A:1010438202519 . Bioscience Reports

Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore

Oliveira, P.J.; Coxito, P.M.; Rolo, A.P.; Santos, D.L.; Palmeira, C.M.; Moreno, A.J.M., 2001. European Journal of Pharmacology. 231 - 237. 3. 412. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS . 10.1016/S0014-2999(01)00745-2 . European Journal of Pharmacology

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury

Oliveira, P.J., 2001. Cardiovascular Toxicology. 205 - 213. 3. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS . 10.1385/CT:1:3:205 . Cardiovascular Toxicology

Doxorubicin-induced persistent oxidative stress to cardiac myocytes

Zhou, S.; Palmeira, C.M.; Wallace, K.B., 2001. Toxicology Letters. 151 - 157. 3. 121. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035912594&partnerID=MN8TOARS . 10.1016/S0378-4274(01)00329-0 . Toxicology Letters

Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?

Oliveira, P.J., 2001. Life Sciences. 123 - 132. 2. 69. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS . 10.1016/S0024-3205(01)01109-2 . Life Sciences

Prion Human Diseases: 14-3-3 Protein Utility in the Diagnosis

Grazina, Manuela; Silva, FMP; Oliveira, CR, 2001. Sinapse. 10 - 16. 1. 1. 2001. published Sinapse

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury

Oliveira, P.J.; Rolo, A.P.; Palmeira, C.M.; Moreno, A.J.M., 2001. Cardiovascular Toxicology. 205 - 213. 3. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS . 10.1385/CT:1:3:205 . Cardiovascular Toxicology

Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial K<inf>ATP</inf> channels?

Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M., 2001. Life Sciences. 123 - 132. 2. 69. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS . 10.1016/S0024-3205(01)01109-2 . Life Sciences

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate.

Oliveira PJ; Rolo AP; Seiça R; Palmeira CM; Santos MS; Moreno AJ; Oliveira, P.J.; et al, 2001. Bioscience Reports. 45 - 53. 1. 21. 2001. http://europepmc.org/abstract/med/11508693 . 10.1023/a:1010482017540 . Bioscience Reports

Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore

Rolo, A.P., 2001. Biochemical Pharmacology. 1449 - 1454. 11. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00620-7 . Biochemical Pharmacology

Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress

Santos, M.S.; Santos, D.L.; Palmeira, C.M.; Seiça, R.; Moreno, A.J.; Oliveira, C.R., 2001. Diabetes/Metabolism Research and Reviews. 223 - 230. 3. 17. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034944055&partnerID=MN8TOARS . 10.1002/dmrr.200 . Diabetes/Metabolism Research and Reviews

Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM; Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2000. Toxicological Sciences. 177 - 185. 1. 57. 2000. http://europepmc.org/abstract/med/10966524 . 10.1093/toxsci/57.1.177 . Toxicological Sciences

Carvedilol inhibits the exogenous NADH dehydrogenase in rat heart mitochondria

Oliveira, P.J., 2000. Archives of Biochemistry and Biophysics. 279 - 285. 2. 374. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034652094&partnerID=MN8TOARS . 10.1006/abbi.1999.1624 . Archives of Biochemistry and Biophysics

Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids

Palmeira, C.M.; Rana, M.I.; Frederick, C.B.; Wallace, K.B., 2000. Biochemical and Biophysical Research Communications. 431 - 435. 2. 272. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616658&partnerID=MN8TOARS . 10.1006/bbrc.2000.2797 . Biochemical and Biophysical Research Communications

Cholestasis and mitochondrial dysfunction: A review

Rolo, A.P.; Palmeira, C.M., 2000. Toxic Substance Mechanisms. 83 - 98. 2. 19. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034458883&partnerID=MN8TOARS . 10.1080/10769180052008878 . Toxic Substance Mechanisms

Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2000. 2000. http://europepmc.org/abstract/med/10966524 . 10.1093/toxsci/57.1.177 .

Effects of carvedilol on isolated heart mitochondria: Evidence for a protonophoretic mechanism

Oliveira, P.J., 2000. Biochemical and Biophysical Research Communications. 82 - 87. 1. 276. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034675219&partnerID=MN8TOARS . 10.1006/bbrc.2000.3374 . Biochemical and Biophysical Research Communications

Age-related alterations in liver mitochondrial bioenergetics of diabetic Goto-Kakizaki rats.

Ferreira FM; Seiça R; Santos MS; Palmeira CM; Ferreira, F.M.L.; Seiça, R.; Santos, M.S.; Palmeira, C.M., 1999. Acta Diabetologica. 173 - 177. 4. 36. 1999. http://europepmc.org/abstract/med/10664324 . 10.1007/s005920050163 . Acta Diabetologica

Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration

Serrano, J.; Palmeira, C.M.; Kuehl, D.W.; Wallace, K.B., 1999. Biochimica et Biophysica Acta - Bioenergetics. 201 - 205. 1. 1411. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032961434&partnerID=MN8TOARS . 10.1016/S0005-2728(99)00011-0 . Biochimica et Biophysica Acta - Bioenergetics

Higher efficiency of the liver phosphorylative system in diabetic Goto-Kakizaki (GK) rats

Palmeira, C.M.; Ferreira, F.M.L.; Santos, D.L.; Ceiça, R.; Suzuki, K.-I.; Santos, M.S., 1999. FEBS Letters. 103 - 106. 2. 458. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032842698&partnerID=MN8TOARS . 10.1016/S0014-5793(99)01144-8 . FEBS Letters

Alterations of liver mitochondrial bioenergetics in diabetic Goto- Kakizaki rats

Ferreira, F.M.L.; Palmeira, C.M.; Seiça, R.; Santos, M.S., 1999. Metabolism: Clinical and Experimental. 1115 - 1119. 9. 48. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032857256&partnerID=MN8TOARS . 10.1016/S0026-0495(99)90124-5 . Metabolism: Clinical and Experimental

Herbicide-induced mitochondrial and cellular liver toxicity: A review of paraquat, dinoseb, and 2,4-D effects

Palmeira, C.M., 1999. Toxic Substance Mechanisms. 187 - 204. 4. 18. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033457940&partnerID=MN8TOARS . 10.1080/107691899229070 . Toxic Substance Mechanisms

Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients.

Fernandes MA; Proenca MT; Nogueira AJ; Grazina MM; Oliveira LM; Fernandes AI; Santiago B; et al, 1999. International journal of molecular medicine. 179 - 186. 2. 4. 1999. http://europepmc.org/abstract/med/10402486 . International journal of molecular medicine

Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relationship to mitochondrial antioxidant capacity

Ferreira, F.M.L.; Palmeira, C.M.; Matos, M.J.; Seiç, R.; Santos, M.S., 1999. Life Sciences. 1013 - 1025. 10. 65. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033618489&partnerID=MN8TOARS . 10.1016/S0024-3205(99)00332-X . Life Sciences

Ischemic heart disease: The role of mitochondria - Carvedilol prevents lipid peroxidation of mitochondrial membranes

Moreno, A.J.M.; Santos, D.J.S.L.; Palmeira, C.M.; Moreno AJ; Santos DJ; Palmeira CM, 1998. Revista Portuguesa de Cardiologia. 63 - 77. SUPPL. 2. 17. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031759966&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Acrylic acid induces the glutathione-independent mitochondrial permeability transition in vitro

Custodio, J.B.A.; Palmeira, C.M.; Moreno, A.J.; Wallace, K.B., 1998. Toxicological Sciences. 19 - 27. 1. 43. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031831694&partnerID=MN8TOARS . 10.1006/toxs.1998.2448 . Toxicological Sciences

Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones

Palmeira, C.M.; Wallace, K.B., 1997. Toxicology and Applied Pharmacology. 338 - 347. 2. 143. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030932708&partnerID=MN8TOARS . 10.1006/taap.1996.8099 . Toxicology and Applied Pharmacology

Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin

Palmeira, C.M.; Serrano, J.; Kuehl, D.W.; Wallace, K.B., 1997. Biochimica et Biophysica Acta - Bioenergetics. 101 - 106. 2. 1321. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030880285&partnerID=MN8TOARS . 10.1016/S0005-2728(97)00055-8 . Biochimica et Biophysica Acta - Bioenergetics

Mercuric chloride toxicity in rat liver mitochondria and isolated hepatocytes

Palmeira, C.M.; Madeira, V.M.C., 1997. Environmental Toxicology and Pharmacology. 229 - 235. 3. 3. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030758726&partnerID=MN8TOARS . 10.1016/S1382-6689(97)00018-5 . Environmental Toxicology and Pharmacology

Determination of 8-hydroxydeoxyguanosine in biological tissue by liquid chromatography/electrospray ionization-mass spectrometry/mass spectrometry

Serrano, J.; Palmeira, C.M.; Wallace, K.B.; Kuehl, D.W., 1996. Rapid Communications in Mass Spectrometry. 1789 - 1791. 14. 10. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030478989&partnerID=MN8TOARS . 10.1002/(SICI)1097-0231(199611)10:14<1789::AID-RCM752>3.0.CO;2-6 . Rapid Communications in Mass Spectrometry

Continuous monitoring of mitochondrial membrane potential in hepatocyte cell suspensions

Palmeira, C.M.; Moreno, A.J.M.; Madeira, V.M.C.; Wallace, K.B., 1996. Journal of Pharmacological and Toxicological Methods. 35 - 43. 1. 35. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029925338&partnerID=MN8TOARS . 10.1016/1056-8719(95)00131-X . Journal of Pharmacological and Toxicological Methods

Effects of paraquat, dinoseb and 2,4-D on intracellular calcium and on vasopressin-induced calcium mobilization in isolated hepatocytes

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Archives of Toxicology. 460 - 466. 7. 69. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029054234&partnerID=MN8TOARS . 10.1007/s002040050199 . Archives of Toxicology

Mitochondrial bioenergetics is affected by the herbicide paraquat

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Biochimica et Biophysica Acta - Bioenergetics. 187 - 192. 2. 1229. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028961733&partnerID=MN8TOARS . 10.1016/0005-2728(94)00202-G . Biochimica et Biophysica Acta - Bioenergetics

Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: A study in isolated hepatocytes

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Toxicology Letters. 115 - 123. 2-3. 81. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029590153&partnerID=MN8TOARS . 10.1016/0378-4274(95)03414-5 . Toxicology Letters

Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1994. Toxicology and Applied Pharmacology. 50 - 57. 1. 127. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028146853&partnerID=MN8TOARS . 10.1006/taap.1994.1138 . Toxicology and Applied Pharmacology

Anodic behavior of someVinca alkaloids with cytostatic activity: Effect of pH

Brett, A. M. Oliveira; Grazina, M. M. M.; Macedo, T. R. A.; Raimundo, D., 1994. Electroanalysis. 57 - 61. 1. 6. 1994. http://dx.doi.org/10.1002/elan.1140060111 . 10.1002/elan.1140060111 . published Electroanalysis

Metabolic alterations in hepatocytes promoted by the herbicides paraquat, dinoseb and 2,4-D

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1994. Archives of Toxicology. 24 - 31. 1. 68. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028009773&partnerID=MN8TOARS . 10.1007/s002040050025 . Archives of Toxicology

A study of the electrochemical oxidation of Navelbine.

Brett AM; Grazina MM; Macedo TR; Oliveira C; Raimundo D; Brett, A.M.O.; Grazina, M.M.M.; et al, 1993. Journal of Pharmaceutical and Biomedical Analysis. 203 - 206. 3. 11. 1993. http://europepmc.org/abstract/med/8518318 . 10.1016/0731-7085(93)80197-9 . Journal of Pharmaceutical and Biomedical Analysis

Linkage and association study of the Dopamine D4 receptor gene and Psychosis

Petronis, A; Grazina, Manuela; Vicente, A.C.; Pato, CN; Azevedo, MHP; Meltzer, HY; Lieberman, JA; et al, 1993. Psychiatric Genetics. 155 - 156. 3. 1993. published Psychiatric Genetics

Dopaminergic system in Mexican schizophrenics

Nicoli, H; Sidenberg, D; Camarena, B; Guerra, C; Grazina, Manuela; Petronis, A; Kennedy, JL, 1993. Rev. Inv. Clin. 345 - 352. 45. 4. 1993. published Rev. Inv. Clin

Membrane lipid peroxidation induces changes in ¿-[3H]aminobutyric acid transport and calcium uptake by synaptosomes

Palmeira, C.M.; Santos, M.S.; Carvalho, A.P.; Oliveira, C.R.; Palmeira CM; Santos MS; Carvalho AP; Oliveira CR, 1993. Brain Research. 117 - 123. 1-2. 609. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027309463&partnerID=MN8TOARS . 10.1016/0006-8993(93)90863-I . Brain Research

Electrochemical study of a group of anticancer drugs

Ana Maria Oliveira Brett; Grazina, Manuela; Macedo, T.R.A.; Raimundo, D., 1993. Portugaliae Electrochimica Acta. 129 - 132. 11. 1993. published Portugaliae Electrochimica Acta

Partitioning and membrane disordering effects of dopamine antagonists: Influence of lipid peroxidation, temperature, and drug concentration

Palmeira, C.M.; Oliveira, C.R., 1992. Archives of Biochemistry and Biophysics. 161 - 171. 1. 295. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026729101&partnerID=MN8TOARS . 10.1016/0003-9861(92)90502-N . Archives of Biochemistry and Biophysics

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