Cristina Isabel Marques Maurício de Carvalho

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Correia, Sónia Catarina; Carvalho, Cristina; Campos, Elisa Julião; Baptista, Filipa Isabel; Moreira, Paula Isabel; Ambrósio, António Francisco, Molecular Neurobiology. 2021. http://dx.doi.org/10.1007/s12035-021-02316-x . 10.1007/s12035-021-02316-x . Molecular Neurobiology

Diabetes-Alzheimer´s disease link: Targeting mitochondrial dysfunction and redox imbalance

Carvalho, Cristina; Cardoso, Susana, Antioxidants & Redox Signaling. 2020. http://dx.doi.org/10.1089/ars.2020.8056 . 10.1089/ars.2020.8056 . Antioxidants & Redox Signaling

Post-translational modifications in brain health and disease

Correia, S.C.; Carvalho, C.; Cardoso, S.; Moreira, P.I., Biochimica et Biophysica Acta - Molecular Basis of Disease. 1947 - 1948. 8. 1865. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065912707&partnerID=MN8TOARS . 10.1016/j.bbadis.2019.05.006 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Oxidative stress: A major player in cerebrovascular alterations associated to neurodegenerative events

Carvalho, C.; Moreira, P.I., Frontiers in Physiology. JUL. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049844811&partnerID=MN8TOARS . 10.3389/fphys.2018.00806 . Frontiers in Physiology

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, E.; Sebastião, I.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.; Duarte, A.I., Molecular Neurobiology. 4030 - 4050. 5. 55. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020070525&partnerID=MN8TOARS . 10.1007/s12035-017-0622-3 . Molecular Neurobiology

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al, Molecular Neurobiology. 6471 - 6489. 8. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Plácido, A.I.; Pereira, C.M.F.; Correira, S.C.; Carvalho, C.; Oliveira, C.R.; Moreira, P.I., Molecular Neurobiology. 154 - 168. 1. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953229269&partnerID=MN8TOARS . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Mitochondria in Alzheimer's Disease and Diabetes-Associated Neurodegeneration: License to Heal!

Carvalho, Cristina, Handb Exp Pharmacol.. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28251365 . 10.1007/164_2017_3 . Handb Exp Pharmacol.

Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Carvalho, C.; Correia, S.C.; Perry, G.; Castellani, R.J.; Moreira, P.I.; Carvalho, Cristina, Journal of Neural Transmission. 107 - 111. 2. 123. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957851903&partnerID=MN8TOARS . 10.1007/s00702-015-1367-7 . Journal of Neural Transmission

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I., Brain Pathology. 632 - 647. 5. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS . 10.1111/bpa.12402 . Brain Pathology

Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice

Sena, C.M.; Pereira, A.M.; Carvalho, C.; Fernandes, R.; Seiça, R.M.; Oliveira, C.R.; Moreira, P.I., Journal of Alzheimer's Disease. 127 - 138. 1. 45. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924181831&partnerID=MN8TOARS . 10.3233/JAD-141008 . Journal of Alzheimer's Disease

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Cristina Carvalho; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1665 - 1675. 8. 1852. 2015. http://dx.doi.org/10.1016/j.bbadis.2015.05.001 . 10.1016/j.bbadis.2015.05.001 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., Expert Review of Neurotherapeutics. 867 - 884. 8. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics

Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; et al, CNS and Neurological Disorders - Drug Targets. 518 - 533. 4. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS . 10.2174/1871527314666150429112353 . CNS and Neurological Disorders - Drug Targets

Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide.

Carvalho, Cristina, World J Diabetes. 2015. https://www.ncbi.nlm.nih.gov/pubmed/26131323 . 10.4239/wjd.v6.i6.807 . World J Diabetes

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I., Biochimica et Biophysica Acta - Molecular Basis of Disease. 1154 - 1166. 7. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I., Molecular and Cellular Biochemistry. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS . 10.1007/s11010-014-2076-5 . Molecular and Cellular Biochemistry

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status

Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I., Journal of Bioenergetics and Biomembranes. 347 - 355. 5. 46. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919396245&partnerID=MN8TOARS . 10.1007/s10863-014-9551-2 . Journal of Bioenergetics and Biomembranes

Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes

Carvalho, C.; Correia, S.C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., Current Neurovascular Research. 330 - 339. 4. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925786114&partnerID=MN8TOARS . Current Neurovascular Research

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

Cardoso, S.; Correia, S.; Carvalho, C.; Candeias, E.; Plácido, A.I.; Duarte, A.I.; Seiça, R.M.; Moreira, P.I.; Carvalho, Cristina, Journal of Bioenergetics and Biomembranes. 119 - 131. 1-2. 47. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922536968&partnerID=MN8TOARS . 10.1007/s10863-014-9580-x . Journal of Bioenergetics and Biomembranes

Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions

Carvalho, C.; Katz, P.S.; Dutta, S.; Katakam, P.V.G.; Moreira, P.I.; Busija, D.W., Journal of Alzheimer's Disease. 75 - 83. 1. 38. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887249119&partnerID=MN8TOARS . 10.3233/JAD-130464 . Journal of Alzheimer's Disease

Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an “Iffy” question!

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., Current Pharmaceutical Design. 6809 - 6822. 38. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS . Current Pharmaceutical Design

Oxidative stress mediates apoptotic effects of ascorbate and dehydroascorbate in human Myelodysplasia cells in vitro

Carvalho, Cristina, 2013. http://www.sciencedirect.com/science/article/pii/S0887233313000738 . 10.1016/j.tiv.2013.03.009 .

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance.

Cardoso S; Santos RX; Correia SC; Carvalho C; Santos MS; Baldeiras I; Oliveira CR; Moreira PI, 2013. http://europepmc.org/abstract/med/22940631 . 10.1016/j.nbd.2012.08.008 .

Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins

Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., Current Molecular Medicine. 586 - 601. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS . 10.2174/1566524011313040010 . Current Molecular Medicine

Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies

Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., Journal of Alzheimer's Disease. 623 - 635. 3. 35. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS . 10.3233/JAD-130005 . Journal of Alzheimer's Disease

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 527 - 541. 4. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Alzheimer disease as a vascular disorder: where do mitochondria fit?

Correia SC; Santos RX; Cardoso S; Carvalho C; Candeias E; Duarte AI; Plácido AI; Santos MS; Moreira PI, 2012. http://europepmc.org/abstract/med/22824543 . 10.1016/j.exger.2012.07.006 .

Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation.

Correia SC; Santos RX; Carvalho C; Cardoso S; Candeias E; Santos MS; Oliveira CR; Moreira PI, 2012. http://europepmc.org/abstract/med/22290178 . 10.1016/j.brainres.2011.12.063 .

The impairment of insulin signaling in Alzheimer's disease

Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I., IUBMB Life. 951 - 957. 12. 64. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS . 10.1002/iub.1098 . IUBMB Life

Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities.

Carvalho C; Cardoso S; Correia SC; Santos RX; Santos MS; Baldeiras I; Oliveira CR; Moreira PI, 2012. http://europepmc.org/abstract/med/22427376 . 10.2337/db11-1186 .

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters.

Cardoso S; Carvalho C; Santos R; Correia S; Santos MS; Seiça R; Oliveira CR; Moreira PI, 2011. http://europepmc.org/abstract/med/20853444 . 10.1002/syn.20863 .

Mitophagy in neurodegeneration: an opportunity for therapy?

Santos RX; Correia SC; Carvalho C; Cardoso S; Santos MS; Moreira PI, 2011. http://europepmc.org/abstract/med/21269269 . 10.2174/138945011795528813 .

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease.

Santos RX; Correia SC; Cardoso S; Carvalho C; Santos MS; Moreira PI, 2011. http://europepmc.org/abstract/med/21447003 . 10.1111/j.1471-4159.2011.07262.x .

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I., Current Pharmaceutical Design. 3381 - 3389. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS . 10.2174/138161211798072490 . Current Pharmaceutical Design

Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.

Carvalho C; Santos MS; Baldeiras I; Oliveira CR; Seiça R; Moreira PI; Carvalho, C.; et al, Current Neurovascular Research. 288 - 300. 4. 7. 2010. http://europepmc.org/abstract/med/20854250 . 10.2174/156720210793180765 . Current Neurovascular Research

Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease?

Correia SC; Santos RX; Cardoso S; Carvalho C; Santos MS; Oliveira CR; Moreira PI; et al, Current Aging Science. 113 - 126. 2. 3. 2010. http://europepmc.org/abstract/med/20167003 . 10.2174/1874609811003020113 . Current Aging Science

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology.

Moreira PI; Carvalho C; Zhu X; Smith MA; Perry G, 2010. http://europepmc.org/abstract/med/19853658 . 10.1016/j.bbadis.2009.10.006 .

Mitochondrial preconditioning: A potential neuroprotective strategy

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, Frontiers in Aging Neuroscience. AUG. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS . 10.3389/fnagi.2010.00138 . Frontiers in Aging Neuroscience

Targeting autophagy in the brain: A promising approach?

Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I.; Santos RX; et al, Central Nervous System Agents in Medicinal Chemistry. 158 - 168. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS . 10.2174/187152410791196350 . Central Nervous System Agents in Medicinal Chemistry

Insulin is a two-edged knife on the brain

Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, Journal of Alzheimer's Disease. 483 - 507. 3. 18. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Doxorubicin: The good, the bad and the ugly effect

Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I., Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

Food deprivation promotes oxidative imbalance in rat brain

Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al, Journal of Food Science. 1. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS . 10.1111/j.1750-3841.2008.00982.x . Journal of Food Science

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.

Cardoso S; Santos R; Correia S; Carvalho C; Zhu X; Lee H; Casadesus G; et al, Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular. 2009. http://europepmc.org/abstract/PMC/PMC3978547 . Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.

Carvalho C; Correia SC; Santos RX; Cardoso S; Moreira PI; Clark TA; Zhu X; Smith MA; Perry G, 2009. http://europepmc.org/abstract/med/19830532 . 10.1007/s10863-009-9247-1 .

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, Susana; Santos, Renato X.; Carvalho, Cristina; Correia, Sónia; Pereira, Gonçalo C.; Pereira, Susana S.; Oliveira, Paulo J.; et al, 2008. http://hdl.handle.net/10316/10086 . https://doi.org/10.1016/j.freeradbiomed.2008.08.008 .

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

Correia S; Carvalho C; Santos MS; Seiça R; Oliveira CR; Moreira PI, 2008. http://europepmc.org/abstract/med/18991752 . 10.2174/138955708786369546 .

Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage.

Cardoso S; Santos RX; Carvalho C; Correia S; Pereira GC; Pereira SS; Oliveira PJ; et al, 2008. http://europepmc.org/abstract/med/18775776 . 10.1016/j.freeradbiomed.2008.08.008 .

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

Correia S; Carvalho C; Santos MS; Proença T; Nunes E; Duarte AI; Monteiro P; et al, 2008. http://europepmc.org/abstract/med/18673148 . 10.2174/157340608784872299 .

Metformin promotes isolated rat liver mitochondria impairment.

Carvalho C; Correia S; Santos MS; Seiça R; Oliveira CR; Moreira PI, 2008. http://europepmc.org/abstract/med/17909944 . 10.1007/s11010-007-9614-3 .