Cláudia Cavadas

Do sperm need to sleep? An overview on the impact of sleep disturbances on male (in)fertility

Cristo, Maria I.; Carvalhas-Almeida, Catarina; Cavadas, Claudia; Ramalho-Santos, João; Amaral, Sandra; Álvaro, Ana Rita , Sleep medicine reviews. 2025. 10.1016/j.smrv.2025.102080 . 10.1016/j.smrv.2025.102080 . accepted Sleep medicine reviews

Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline

Ana Catarina Franco; Helene Martini; Stella Victorelli; Anthony B. Lagnado; Saranya P. Wyles; Jennifer L. Rowsey; Nicholas Pirius; et al, Aging Cell. 2024. doi: 10.1111/acel.14340 . doi: 10.1111/acel.14340 . published Aging Cell

Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

Cavadas, Claudia; Álvaro, Ana Rita ; Leal, Helena; Carvalhas de Almeida, Catarina, Trends Endocrinolology Metabolism. 2024. https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00001-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1043276024000018%3Fshowall%3Dtrue . published Trends Endocrinolology Metabolism

Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes

Sara Carmo-Silva; Marisa Ferreira-Marques; Clévio Nóbrega; Mariana Botelho; Daniela Costa; Célia A Aveleira; Stefan M Pulst; Luís Pereira de Almeida; Claudia Cavadas, Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-21-0272 . 10.1530/JME-21-0272 . Journal of Molecular Endocrinology

Primary cilia shape hallmarks of health and aging.

Silva DF; Cavadas C; Claudia Cavadas, Trends in molecular medicine. 2023. https://doi.org/10.1016/j.molmed.2023.04.001 . 10.1016/j.molmed.2023.04.001 . Trends in molecular medicine

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Lucas, Vasco; Cavadas, Cláudia; Aveleira, Célia Alexandra, Pharmacological Reviews. 675 - 713. 4. 75. 2023. http://dx.doi.org/10.1124/pharmrev.122.000622 . 10.1124/pharmrev.122.000622 . Pharmacological Reviews

Lipodystrophy as a target to delay premature aging

Daniela G. Costa; Marisa Ferreira-Marques; Cláudia Cavadas, Trends in Endocrinology & Metabolism. 2023. https://doi.org/10.1016/j.tem.2023.10.006 . 10.1016/j.tem.2023.10.006 . Trends in Endocrinology & Metabolism

Ghrelin delays premature aging in <scp>Hutchinson-Gilford</scp> progeria syndrome

Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Botelho, Mariana; Carmo-Silva, Sara; Águas, Rodolfo; et al, Aging Cell. 12. 22. 2023. http://dx.doi.org/10.1111/acel.13983 . 10.1111/acel.13983 . published Aging Cell

Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis.

Gaspar LS; Santos-Carvalho A; Santos B; Carvalhas-Almeida C; Barros-Viegas AT; Oliveiros B; Donato H; et al, Sleep medicine reviews. 2022. http://europepmc.org/abstract/med/35753150 . 10.1016/j.smrv.2022.101659 . Sleep medicine reviews

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas, Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02257-y . 10.1007/s40520-022-02257-y . Aging Clinical and Experimental Research

The impact of insomnia on frailty and the hallmarks of aging

Catarina Carvalhas-Almeida; Cláudia Cavadas; Ana Rita Álvaro, Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02310-w . 10.1007/s40520-022-02310-w . Aging Clinical and Experimental Research

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway.

Leal H; Cardoso J; Valério P; Quatorze M; Carmona V; Cunha-Santos J; Pereira de Almeida L; et al, International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/35743232 . 10.3390/ijms23126790 . International journal of molecular sciences

PET Imaging of the Neuropeptide Y System: A Systematic Review.

Fonseca ICF; Castelo-Branco M; Cavadas C; Abrunhosa AJ, Molecules (Basel, Switzerland). 2022. http://europepmc.org/abstract/med/35744852 . 10.3390/molecules27123726 . Molecules (Basel, Switzerland)

A look on food intake and satiety: from humans to rodent models

Cavadas, Claudia; Almeida, Cláudia; Cavadas, Cláudia; Carmo-Silva, Sara, Nutrition Reviews. 1942 - 1957. 8. 80. 2022. http://dx.doi.org/10.1093/nutrit/nuac010 . 10.1093/nutrit/nuac010 . Nutrition Reviews

Skin senescence: mechanisms and impact on whole-body aging

Ana Catarina Franco; Célia Aveleira; Cláudia Cavadas, Trends in Molecular Medicine. 2022. https://doi.org/10.1016/j.molmed.2021.12.003 . 10.1016/j.molmed.2021.12.003 . Trends in Molecular Medicine

Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea (EBioMedicine)

Laetitia S. Gaspar; Janina Hesse; Müge Yalçin; Bárbara Santos; Catarina Carvalhas-Almeida; Mafalda Ferreira; Joaquim Moita; et al, EBioMedicine. 2021. https://doi.org/10.1016/j.ebiom.2021.103248 . 10.1016/j.ebiom.2021.103248 . in press EBioMedicine

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

Cavadas, Claudia, Aging. 2021. https://doi.org/10.18632/aging.202805 . 10.18632/aging.202805 . Aging

Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and rescues hepatic mitochondrial bioenergetics

Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Matos, P.; et al, Nutrients. 12. 13. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119606449&partnerID=MN8TOARS . 10.3390/nu13124192 . Nutrients

Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases

Ribeiro, R.F.N.; Cavadas, C.; Silva, M.M.C., Drug Discovery Today. 1620 - 1641. 7. 26. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104421181&partnerID=MN8TOARS . 10.1016/j.drudis.2021.03.015 . Drug Discovery Today

Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease.

Cavadas, Claudia, Scientific reports. 2021. https://europepmc.org/articles/PMC7870889 . 10.1038/s41598-021-82339-5 . Scientific reports

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.

Cavadas, Claudia, Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, The Journals of Gerontology: Series A. 1073 - 1078. 6. 75. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models

Santana, M.M.; Paixão, S.; Cunha-Santos, J.; Silva, T.P.; Trevino-Garcia, A.; Gaspar, L.S.; Nóbrega, C.; et al, Journal of Translational Medicine. 1. 18. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083210032&partnerID=MN8TOARS . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine

The Superpowers of Our Sleep

Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . published Frontiers for Young Minds

Blueberry consumption challenges hepatic mitochondrial bioenergetics and elicits transcriptomics reprogramming in healthy wistar rats

Nunes, S.; Viana, S.D.; Preguiça, I.; Alves, A.; Fernandes, R.; Teodoro, J.S.; Figueirinha, A.; et al, Pharmaceutics. 1 - 29. 11. 12. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096072381&partnerID=MN8TOARS . 10.3390/pharmaceutics12111094 . Pharmaceutics

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Cavadas, Claudia, Pharmacological research. 2020. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological research

The importance of determining circadian parameters in pharmacological studies

Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, British Journal of Pharmacology. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Cavadas, Claudia, Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice

Marques, A.P.; Cunha-Santos, J.; Leal, H.; Sousa-Ferreira, L.; Pereira de Almeida, L.; Cavadas, C.; Rosmaninho-Salgado, J., Biochimica et Biophysica Acta - General Subjects. 403 - 413. 3. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037668547&partnerID=MN8TOARS . 10.1016/j.bbagen.2017.11.012 . Biochimica et Biophysica Acta - General Subjects

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components

Costa, S.; Cavadas, C.; Cavaleiro, C.; Salgueiro, L.; do Céu Sousa, M., Experimental Parasitology. 34 - 40. 190. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047422613&partnerID=MN8TOARS . 10.1016/j.exppara.2018.05.002 . Experimental Parasitology

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress

Spadari, R.C.; Cavadas, C.; de Carvalho, A.E.T.S.; Ortolani, D.; de Moura, A.L.; Vassalo, P.F., Cellular and Molecular Neurobiology. 109 - 120. 1. 38. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032021647&partnerID=MN8TOARS . 10.1007/s10571-017-0557-2 . Cellular and Molecular Neurobiology

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line

Ana Patrícia Marques; Joana Rosmaninho-Salgado; Marta Estrada; Vera Cortez; Rui Jorge Nobre; Cláudia Cavadas, Biochimica et Biophysica Acta (BBA) - General Subjects. 673 - 682. 3. 1861. 2017. https://doi.org/10.1016/j.bbagen.2016.12.005 . 10.1016/j.bbagen.2016.12.005 . Biochimica et Biophysica Acta (BBA) - General Subjects

Unraveling the Role of Ataxin-2 in Metabolism

Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C., Trends in Endocrinology and Metabolism. 309 - 318. 4. 28. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS . 10.1016/j.tem.2016.12.006 . Trends in Endocrinology and Metabolism

The NAD⁺-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Lemos, V.; de Oliveira, R.M.; Naia, L.; Szegö, E.; Ramos, E.; Pinho, S.; Magro, F.; et al, Human Molecular Genetics. 4105 - 4117. 21. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034211658&partnerID=MN8TOARS . 10.1093/hmg/ddx298 . Human Molecular Genetics

Obstructive Sleep Apnea and Hallmarks of Aging

Gaspar, Laetitia S.; Álvaro, Ana Rita; Moita, Joaquim; Cavadas, Cláudia, Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://dx.doi.org/10.1016/j.molmed.2017.06.006 . 10.1016/j.molmed.2017.06.006 . published Trends in Molecular Medicine

Corrigendum to "Intracellular mechanisms coupled to NPY Y<inf>2</inf> and Y<inf>5</inf> receptor activation and lipid accumulation in murine adipocytes" [neuropeptides 46/6 (2012) 359-366]

Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., Neuropeptides. 101 - 101. 57. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950130030&partnerID=MN8TOARS . 10.1016/j.npep.2015.11.089 . Neuropeptides

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . Nature Reviews Endocrinology

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Joana Duarte-Neves; Luís Pereira de Almeida; Cláudia Cavadas, Neurobiology of Disease. 210 - 224. 95. 2016. https://doi.org/10.1016%2Fj.nbd.2016.07.022 . 10.1016/j.nbd.2016.07.022 . Neurobiology of Disease

Antileishmanial activity of antiretroviral drugs combined with miltefosine

Costa, Sonya; Machado, Marisa; Cavadas, Cláudia; do Céu Sousa, Maria, Parasitology Research. 3881 - 3887. 10. 115. 2016. http://dx.doi.org/10.1007/s00436-016-5153-8 . 10.1007/s00436-016-5153-8 . published Parasitology Research

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Ferreira-Marques M; Aveleira CA; Carmo-Silva S; Botelho M; Pereira de Almeida L; Cavadas C; Ferreira-Marques, Marisa; et al, Aging. 1470 - 1484. 7. 8. 2016. http://europepmc.org/abstract/med/27441412 . 10.18632/aging.100996 . Aging

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway

Cunha-Santos, J.; Duarte-Neves, J.; Carmona, V.; Guarente, L.; De Almeida, L.P.; Cavadas, C., Nature Communications. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968928647&partnerID=MN8TOARS . 10.1038/ncomms11445 . Nature Communications

The Adenosinergic System in Diabetic Retinopathy

Vindeirinho, J.; Santiago, A. R.; Cavadas, C.; Ambrósio, A. F.; Santos, P. F., Journal of Diabetes Research. 1 - 8. 2016. 2016. http://dx.doi.org/10.1155/2016/4270301 . 10.1155/2016/4270301 . published Journal of Diabetes Research

Hypothalamic involvement in premature aging laminopathies

Cavadas, Claudia; Cavadas C, Orphanet Journal of Rare Diseases. Suppl 2. 10. 2015. http://dx.doi.org/10.1186/1750-1172-10-s2-o6 . 10.1186/1750-1172-10-s2-o6 . published Orphanet Journal of Rare Diseases

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; et al, European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology

Neuropeptide Y system in the retina: From localization to function

Santos-Carvalho, Ana; Ambrósio, António Francisco; Cavadas, Cláudia, Progress in Retinal and Eye Research. 19 - 37. 47. 2015. http://dx.doi.org/10.1016/j.preteyeres.2015.03.001 . 10.1016/j.preteyeres.2015.03.001 . published Progress in Retinal and Eye Research

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . published Autophagy

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease

Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa; den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Cavadas, Cláudia; Pereira de Almeida, Luís, Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://dx.doi.org/10.1093/hmg/ddv271 . 10.1093/hmg/ddv271 . published Human Molecular Genetics

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective ActionsIn Vitro

Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; et al, ASN Neuro. 4. 7. 2015. http://dx.doi.org/10.1177/1759091415598292 . 10.1177/1759091415598292 . published ASN Neuro

Neuropeptide Y: An Anti-Aging Player?

Botelho, Mariana; Cavadas, Cláudia, Trends in Neurosciences. 701 - 711. 11. 38. 2015. http://dx.doi.org/10.1016/j.tins.2015.08.012 . 10.1016/j.tins.2015.08.012 . published Trends in Neurosciences

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

Gomes, Pedro; Fleming Outeiro, Tiago; Cavadas, Cláudia, Trends in Pharmacological Sciences. 756 - 768. 11. 36. 2015. http://dx.doi.org/10.1016/j.tips.2015.08.001 . 10.1016/j.tips.2015.08.001 . published Trends in Pharmacological Sciences

Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress

Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, Neuroscience. 1 - 11. 273. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901323540&partnerID=MN8TOARS . 10.1016/j.neuroscience.2014.04.042 . Neuroscience

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Santos-Carvalho, A.; Álvaro, A.R.; Martins, J.; Ambrósio, A.F.; Cavadas, C., Progress in Neurobiology. 70 - 79. 112. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890802011&partnerID=MN8TOARS . 10.1016/j.pneurobio.2013.10.002 . Progress in Neurobiology

Role of hypothalamic neurogenesis in feeding regulation

Sousa-Ferreira, L.; Almeida, L.P.D.; Cavadas, C., Trends in Endocrinology and Metabolism. 80 - 88. 2. 25. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892986633&partnerID=MN8TOARS . 10.1016/j.tem.2013.10.005 . Trends in Endocrinology and Metabolism

Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro

Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . accepted PLoS ONE

Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System

Vindeirinho, J.; Costa, G.N.; Correia, M.B.; Cavadas, C.; Santos, P.F., PLoS ONE. 6. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879548830&partnerID=MN8TOARS . 10.1371/journal.pone.0067499 . PLoS ONE

Progenitor cells in chromospheres: In response to Arthur S. Tischler

Santana, M.M.; Ehrhart-Bornstein, M.; Cavadas, C., Stem Cells Translational Medicine. 1020 - 1021. 12. 2. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888415377&partnerID=MN8TOARS . 10.5966/sctm.2013-0062 . Stem Cells Translational Medicine

Neuropeptide y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

Santos-Carvalho, A.; Elvas, F.; Álvaro, A.R.; Ambrósio, A.F.; Cavadas, C., Cell Death and Disease. 5. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879394627&partnerID=MN8TOARS . 10.1038/cddis.2013.160 . Cell Death and Disease

Neuropeptide Y receptors Y1 and Y2 are present in neurons and glial cells in rat retinal cells in culture

Santos-Carvalho, A.; Aveleira, C.A.; Elvas, F.; Ambrósio, A.F.; Cavadas, C., Investigative Ophthalmology and Visual Science. 429 - 443. 1. 54. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874719907&partnerID=MN8TOARS . 10.1167/iovs.12-10776 . Investigative Ophthalmology and Visual Science

Dipeptidyl-peptidase-IV by cleaving neuropeptide y induces lipid accumulation and PPAR-¿ expression

Cavadas, Claudia, BBA. 49 - 54. 1. 37. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865246554&partnerID=MN8TOARS . 10.1016/j.peptides.2012.06.014 . BBA

Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla

Santana, M.M.; Chung, K.-F.; Vukicevic, V.; Rosmaninho-Salgado, J.; Kanczkowski, W.; Cortez, V.; Hackmann, K.; et al, Stem Cells Translational Medicine. 783 - 791. 11. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873024306&partnerID=MN8TOARS . 10.5966/sctm.2012-0022 . Stem Cells Translational Medicine

Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes

Rosmaninho-Salgado, J.; Cortez, V.; Estrada, M.; Santana, M.M.; Gonçalves, A.; Marques, A.P.; Cavadas, C., Neuropeptides. 359 - 366. 6. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869870468&partnerID=MN8TOARS . 10.1016/j.npep.2012.08.006 . Neuropeptides

Regulation of catecholamine release in human adrenal chromaffin cells by ß-adrenoceptors

Cortez, V.; Santana, M.; Marques, A.P.; Mota, A.; Rosmaninho-Salgado, J.; Cavadas, C., Neurochemistry International. 387 - 393. 4. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857026869&partnerID=MN8TOARS . 10.1016/j.neuint.2011.12.018 . Neurochemistry International

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

Costa, G.N.; Vindeirinho, J.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F., Molecular and Cellular Neuroscience. 113 - 123. 1. 50. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860624256&partnerID=MN8TOARS . 10.1016/j.mcn.2012.04.003 . Molecular and Cellular Neuroscience

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and orexin-a and differentiate to functional neurons

Sousa-Ferreira, L.; Álvaro, A.R.; Aveleira, C.; Santana, M.; Brandão, I.; Kügler, S.; de Almeida, L.P.; Cavadas, C., PLoS ONE. 5. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955917559&partnerID=MN8TOARS . 10.1371/journal.pone.0019745 . PLoS ONE

Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE

Adipose Tissue Changes Induced By the DPPIV Inhibitors (Gliptins): In Vivo and In Vitro Studies

Salgado, Joana; Estrada, Marta; Marques, Ana; Cortez, Vera; Reis, Flavio; Pereira, Frederico; Santana, Magda; Cavadas, Claudia, Obesity. 2011. https://publons.com/wos-op/publon/33859176/ . Obesity

Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat

Martins, J.; Castelo-Branco, M.; Batista, A.; Oliveiros, B.; Santiago, A.R.; Galvão, J.; Fernandes, E.; et al, PLoS ONE. 12. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84455161646&partnerID=MN8TOARS . 10.1371/journal.pone.0029583 . PLoS ONE

Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide y in noradrenergic neurons

Ruohonen, S.T.; Savontaus, E.; Rinne, P.; Rosmaninho-Salgado, J.; Cavadas, C.; Ruskoaho, H.; Koulu, M.; Pesonen, U., Neuroendocrinology. 351 - 360. 3. 89. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349122908&partnerID=MN8TOARS . 10.1159/000188602 . Neuroendocrinology

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide

Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; Duarte, E.P.; Cavadas, C., Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . Journal of Neurochemistry

Neuropeptide y inhibits [Ca2+]i changes in rat retinal neurons through NPY Y1, Y4, and Y5 receptors

Álvaro, A.R.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549153628&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06079.x . Journal of Neurochemistry

Neuropeptide Y stimulates retinal neural cell proliferation - Involvement of nitric oxide

Álvaro, A.R.; Martins, J.; Araújo, I.M.; Rosmaninho-Salgado, J.; Ambrósio, A.F.; Cavadas, C., Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649189136&partnerID=MN8TOARS . 10.1111/j.1471-4159.2008.05334.x . Journal of Neurochemistry

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., Neuroscience. 97 - 105. 1. 152. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39649105016&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.12.027 . Neuroscience

Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: A role for microglia

Xapelli, S.; Bernardino, L.; Ferreira, R.; Grade, S.; Silva, A.P.; Salgado, J.R.; Cavadas, C.; et al, European Journal of Neuroscience. 2089 - 2102. 8. 27. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049112780&partnerID=MN8TOARS . 10.1111/j.1460-9568.2008.06172.x . European Journal of Neuroscience

Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells

Rosmaninho-Salgado, J.; Araújo, I.M.; Álvaro, A.R.; Duarte, E.P.; Cavadas, C., Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . Journal of Neurochemistry

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

NPY Y<inf>1</inf> receptor is not involved in the hemodynamic response to an acute cold pressor test in mice

Cavadas, C.; Waeber, B.; Pedrazzini, T.; Grand, D.; Aubert, J.-F.; Buclin, T.; Grouzmann, E., Peptides. 315 - 319. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846574363&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.022 . Peptides

Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells

Rosmaninho-Salgado, J.; Álvaro, A.R.; Grouzmann, E.; Duarte, E.P.; Cavadas, C., Peptides. 310 - 314. 2. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846606438&partnerID=MN8TOARS . 10.1016/j.peptides.2006.11.015 . Peptides

Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion

Cavadas, C.; Céfai, D.; Rosmaninho-Salgado, J.; Vieira-Coelho, M.A.; Moura, E.; Busso, N.; Pedrazzini, T.; et al, Proceedings of the National Academy of Sciences of the United States of America. 10497 - 10502. 27. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745899338&partnerID=MN8TOARS . 10.1073/pnas.0600913103 . Proceedings of the National Academy of Sciences of the United States of America

Neuropeptide Y expression, localization and cellular transducing effects in HUVEC

Silva, A.P.; Kaufmann, J.E.; Vivancos, C.; Fakan, S.; Cavadas, C.; Shaw, P.; Brunner, H.R.; Vischer, U.; Grouzmann, E., Biology of the Cell. 457 - 467. 6. 97. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21044442442&partnerID=MN8TOARS . 10.1042/BC20040102 . Biology of the Cell

Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats

Silva, A.P.; Xapelli, S.; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; et al, Journal of Neurochemistry. 163 - 170. 1. 93. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144388681&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.03005.x . Journal of Neurochemistry

The putative neuroprotective role of neuropeptide Y in the central nervous system

Silva, A.P.; Xapelli, S.; Grouzmann, E.; Cavadas, C., Current Drug Targets: CNS and Neurological Disorders. 331 - 347. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144457255&partnerID=MN8TOARS . 10.2174/1568007054546153 . Current Drug Targets: CNS and Neurological Disorders

NPY, NPY receptors, and DPP IV activity are modulated by LPS, TNF-a and IFN-¿ in HUVEC

Silva, A.P.; Cavadas, C.; Baïsse-Agushi, B.; Spertini, O.; Brunner, H.R.; Grouzmann, E., Regulatory Peptides. 71 - 79. 1-3. 116. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242329827&partnerID=MN8TOARS . 10.1016/S0167-0115(03)00191-5 . Regulatory Peptides

Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT<inf>1</inf>receptor

Cavadas, C.; Grand, D.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., Regulatory Peptides. 61 - 65. 1-3. 111. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037471366&partnerID=MN8TOARS . 10.1016/S0167-0115(02)00253-7 . Regulatory Peptides

Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice

Grouzmann, E.; Cavadas, C.; Grand, D.; Moratel, M.; Aubert, J.-F.; Brunner, H.R.; Mazzolai, L., Pflugers Archiv European Journal of Physiology. 254 - 258. 2. 447. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842265696&partnerID=MN8TOARS . 10.1007/s00424-003-1140-x . Pflugers Archiv European Journal of Physiology

Neuropeptide Y and its receptors as potential therapeutic drug targets

Silva, A.P.; Cavadas, C.; Grouzmann, E., Clinica Chimica Acta. 3 - 25. 1-2. 326. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036889596&partnerID=MN8TOARS . 10.1016/S0009-8981(02)00301-7 . Clinica Chimica Acta

Catecholamine and Neuropeptide Y Secretion from Human Adrenal Chromaffin Cells

CAVADAS, CLÁUDIA; RIBEIRO, CARLOS ALBERTO FONTES; COTRIM, MARIA DULCE; MOSIMANN, FRANÇOIS; BRUNNER, HANS R.; GROUZMANN, ERIC; Cavadas C; et al, Annals of the New York Academy of Sciences. 332 - 334. 1. 971. 2002. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04488.x . 10.1111/j.1749-6632.2002.tb04488.x . Annals of the New York Academy of Sciences

Differential secretion of catecholamine and neuropeptide Y in response to KCl from mice chromaffin cells.

Cavadas C; Silva AP; Cotrim MD; Ribeiro CA; Brunner HR; Grouzmann E, 2002. http://europepmc.org/abstract/med/12438145 . 10.1111/j.1749-6632.2002.tb04489.x .

Loss of dipeptidylpeptidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P in the nasal mucosa.

Grouzmann, E.; Monod, M.; Landis, B.; Wilk, S.; Brakch, N.; Nicoucar, K.; Giger, R.; et al, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1132 - 1134. 9. 16. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036634815&partnerID=MN8TOARS . published The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dibasic cleavage site is required for sorting to the regulated secretory pathway for both pro- and neuropeptide Y

Brakch, N.; Allemandou, F.; Cavadas, C.; Grouzmann, E.; Brunner, H.R., Journal of Neurochemistry. 1166 - 1175. 6. 81. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036316744&partnerID=MN8TOARS . 10.1046/j.1471-4159.2002.00919.x . Journal of Neurochemistry

NPY regulates catecholamine secretion from human adrenal chromaffin cells

Cavadas, C.; Silva, A.P.; Mosimann, F.; Cotrim, M.D.; Fontes Ribeiro, C.A.; Brunner, H.R.; Grouzmann, E., Journal of Clinical Endocrinology and Metabolism. 5956 - 5963. 12. 86. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035217710&partnerID=MN8TOARS . 10.1210/jc.86.12.5956 . Journal of Clinical Endocrinology and Metabolism

Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y

Bergonzelli, G.E.; Pralong, F.P.; Glauser, M.; Cavadas, C.; Grouzmann, E.; Gaillard, R.C.; Bergonzelli GE; et al, Diabetes. 2666 - 2672. 12. 50. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035656192&partnerID=MN8TOARS . 10.2337/diabetes.50.12.2666 . Diabetes

Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma

Grouzmann, E.; Fathi, M.; Gillet, M.; De Torrenté, A.; Cavadas, C.; Brunner, H.; Buclin, T.; et al, Clinical Chemistry. 1075 - 1082. 6 I. 47. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035010093&partnerID=MN8TOARS . Clinical Chemistry

Cardiovascular effects of fentanyl in conscious rats

Baechtold, F.; Cavadas, C.; Gasser, D.; Markert, M.; Grouzmann, E.; Peterson, K.L.; Waeber, B.; Feihl, F., Pflugers Archiv European Journal of Physiology. 155 - 162. 1. 443. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035161078&partnerID=MN8TOARS . 10.1007/s004240100693 . Pflugers Archiv European Journal of Physiology

In vitro study of the interaction of Tilia europeae L. aqueous extract with GABA(A) receptors in rat brain

Cavadas, C.; Fontes Ribeiro, C.A.; Santos, M.S.; Cunha, A.P.; Macedo, T.; Caramona, M.M.; Cotrim, M.D., Phytotherapy Research. 17 - 21. 1. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031051651&partnerID=MN8TOARS . 10.1002/(SICI)1099-1573(199702)11:1<17::AID-PTR948>3.0.CO;2-6 . Phytotherapy Research

In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABA(A) receptor in rat brain

Cavadas, C.; Araujo, I.; Cotrim, M.D.; Amaral, T.; Cunha, A.P.; Macedo, T.; Fontes Ribeiro, C., Arzneimittel-Forschung/Drug Research. 753 - 755. 7. 45. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063620&partnerID=MN8TOARS . Arzneimittel-Forschung/Drug Research