Envelhecimento
Hipotálamo
Relógios Biológicos
Autofagia
Inflamação
Eixo neuroendócrino e envelhecimento
Hipotálamo: alvo para atrasar o envelhecimento e doenças associadas
Novas moléculas direcionadas para marcadores moleculares e celulares do envelhecimento e doenças associadas ao envelhecimento
Ritmos circadianos no envelhecimento e doenças associadas
O Grupo de Neuroendocrinologia e Envelhecimento tem como missão contribuir para o desenvolvimento de investigação na área do envelhecimento, nomeadamente demonstrar que a intervenção no sistema neuroendócrino, e funções associadas, em modelos experimentais pode atrasar, parar e, em alguns exemplos, reverter as manifestações do envelhecimento e dos distúrbios e doenças associados ao envelhecimento.
O grupo tem competências no estabelecimento de modelos celulares e animais de envelhecimento e distúrbios relacionados à idade (progéria, doenças neurodegenerativas, OSA, OA, insónia, disfunção metabólica e obesidade), marcadores fisiológicos, celulares e moleculares (nomeadamente autofagia , senescência, inflamação), abordagens de transferência de genes, análise do ritmo circadiano, química medicinal, estudos pré-clínicos e atividades de envolvimento do público com a ciência.
Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.
Enhancing ghrelin signaling alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (under submission).
Ferreira-Marques, M (EA15-6C9F-F15E); Carvalho, A; Franco, Ana Catarina; Leal, A; Botelho, M; Carmo-Silva, Sara; Águas, R; et al, 2022. 2022. submitted
Ataxin-2 in the hypothalamus at the crossroads between metabolism & circadian rhythm (under revision)
Carmo-Silva, Sara; Ferreira-Marques, M (EA15-6C9F-F15E); Nóbrega, Clévio David Rodrigues ; Botelho M; Costa, D; Aveleira C; Pulst, Stefan; Almeida, Luís Pereira de; Cavadas, Claudia, 2022. Journal of Molecular Endocrinology. 2022. under revision Journal of Molecular Endocrinology
Leptin enhances progerin clearance and ameliorates the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells (under submission))
Real, AC; Ferreira-Marques, M (EA15-6C9F-F15E); Cortes, Luisa; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2022. 2022. submitted
Skin senescence: mechanisms and impact on whole-body aging
Ana Catarina Franco; Aveleira C; Cavadas, Claudia, 2022. Trends Molecular Medicine. 97 - 109. 2. 28. 2022. published Trends Molecular Medicine
Cellular senescence mechanisms in the context of current biomarkers and senotherapies (under submission)
Vasco Lucas; Claudia Cavadas; Aveleira C, 2022. Pharmacological Reviews. 2022. submitted Pharmacological Reviews
Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun scaffold fabrication
Semitela, Ângela; Ramalho, Gonçalo; Capitão, Ana; Sousa, Cátia; Mendes, Alexandrina F; AAP Marques, Paula; Completo, António, 2022. Journal of Tissue Engineering. 13. 2022. http://dx.doi.org/10.1177/20417314211069342 . 10.1177/20417314211069342 . Journal of Tissue Engineering
The NutriClock Study Protocol - Assessing the Impact of a Chrononutrition Intervention in Patients With Cardiometabolic Disturbances
Lages, Marlene; Gaspar, Laetitia; Carmo-Silva, Sara; Frontini, Roberta; Álvaro, Ana; Cavadas, Cláudia; Fonseca, Rui; et al, 2021. Current Developments in Nutrition. 468 - 468. Supplement. 5. 2021. http://dx.doi.org/10.1093/cdn/nzab039_004 . 10.1093/cdn/nzab039_004 . Current Developments in Nutrition
Copper impair autophagy on zebrafish (Danio rerio) gill epithelium
Luzio, A.; Parra, S.; Costa, B.; Santos, D.; Álvaro, A.R.; Monteiro, S.M., 2021. Environmental Toxicology and Pharmacology. 86. 2021. http://dx.doi.org/10.1016/j.etap.2021.103674 . 10.1016/j.etap.2021.103674 . published Environmental Toxicology and Pharmacology
Effects of short-term exposure to genistein and overfeeding diet on the neural and retinal progenitor competence of adult zebrafish (Danio rerio)
Luzio, A.; Figueiredo, M.; Matos, M.M.; Coimbra, A.M.; Álvaro, A.R.; Monteiro, S.M., 2021. Neurotoxicology and Teratology. 88. 2021. http://dx.doi.org/10.1016/j.ntt.2021.107030 . 10.1016/j.ntt.2021.107030 . published Neurotoxicology and Teratology
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Gaspar, Laetitia S.; Sousa, Cátia; Álvaro, Ana Rita; Cavadas, Cláudia; Mendes, Alexandrina Ferreira, 2021. Pharmacological Research. 164. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research
Long-term Continuous Positive Airway Pressure Treatment Ameliorates Biological Clock Disruptions in Obstructive Sleep Apnea
C014-4DE9-206C; Janina Hesse; Müge Yalçin; 0F1A-8AFD-63A0; Catarina Carvalhas-Almeida; Mafalda Ferreira; B01F-45DC-F6D7; et al, 2021. Ebiomedicine. 2021. in press Ebiomedicine
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Laetitia S. Gaspar; Cátia Sousa; Ana Rita Álvaro; Cláudia Cavadas; Alexandrina Ferreira Mendes, 2021. Pharmacological Research. 105369 - 105369. 2021. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
Multi-layered electrospinning and electrospraying approach: Effect of polymeric supplements on chondrocyte suspension
Semitela, Ângela; Leal Pereira, Andreia; Sousa, Cátia; Mendes, Alexandrina F.; Marques, Paula A.A.P.; Completo, António, 2021. Journal of Biomaterials Applications. 2021. http://dx.doi.org/10.1177/08853282211064403 . 10.1177/08853282211064403 . Journal of Biomaterials Applications
Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line
Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes, 2021. Biomedicines. 777 - 777. 7. 9. 2021. https://doi.org/10.3390/biomedicines9070777 . 10.3390/biomedicines9070777 . Biomedicines
PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.
Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2021. Aging. 2021. accepted Aging
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky D J; Abdel-Aziz A K; ...; Aveleira C; Chun-Kit Tong, 2021. Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . published Autophagy
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A
Expression and function of the nonclassical estrogen receptor, GPR30, in human cartilage and chondrocytes
Madalena Ribeiro; Cátia Sousa; Ana T. Rufino; Fernando Judas; Alexandrina F. Mendes, 2020. Journal of Cellular Physiology. 2020. https://doi.org/10.1002/jcp.29691 . 10.1002/jcp.29691 . Journal of Cellular Physiology
Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity
Mendes, Alexandrina Ferreira , 2020. Scientific Reports. 10. 2020. https://rdcu.be/b3Rts . published Scientific Reports
The Superpowers of Our Sleep
Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . Frontiers for Young Minds
Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases
Mendes, Alexandrina Ferreira , 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences
The importance of determining circadian parameters in pharmacological studies
Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2827 - 2847. 16. 176. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology
The importance of determining circadian parameters in pharmacological studies
Mendes, Alexandrina, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology
Editorial: The Physiology of Inflammation—The Final Common Pathway to Disease
Mendes, Alexandrina, 2018. Frontiers in Physiology. 2018. 10.3389/fphys.2018.01741 . Frontiers in Physiology
Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.
Pólvora-Brandão D; Joaquim M; Godinho I; Aprile D; Álvaro AR; Onofre I; Raposo AC; et al, 2018. Human molecular genetics. 2018. http://europepmc.org/abstract/med/30102380 . 10.1093/hmg/ddy274 . Human molecular genetics
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Exercise-Induced Immune Response
Mendes, Alexandrina, 2018. Journal of Functional Morphology and Kinesiology. 2018. http://www.mdpi.com/2411-5142/3/3/42 . 10.3390/jfmk3030042 . Journal of Functional Morphology and Kinesiology
Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes
Rufino, Ana; Ribeiro, Madalena; Pinto Ferreira, João; Judas, Fernando; Mendes, Alexandrina, 2017. Journal of Functional Morphology and Kinesiology. 2. 2. 2017. http://dx.doi.org/10.3390/jfmk2020015 . 10.3390/jfmk2020015 . Journal of Functional Morphology and Kinesiology
Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation
Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., 2017. Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . published Mediators of Inflammation
Obstructive Sleep Apnea and Hallmarks of Aging
Gaspar, L.S.; Álvaro, A.R.; Moita, J.; Cavadas, C., 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025131167&partnerID=MN8TOARS . 10.1016/j.molmed.2017.06.006 . Trends in Molecular Medicine
Assessment of cell line competence for studies of pharmacological GPR30 modulation
Sousa, Cátia; Ribeiro, Madalena; Rufino, Ana Teresa; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira, 2016. Journal of Receptors and Signal Transduction. 181 - 188. 2. 37. 2016. http://dx.doi.org/10.1080/10799893.2016.1203943 . 10.1080/10799893.2016.1203943 . Journal of Receptors and Signal Transduction
Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53
Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R., 2016. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 138 - 146. 185-186. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS . 10.1016/j.cbpc.2016.03.010 . Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation
Ribeiro, M.; López de Figueroa, P.; Nogueira-Recalde, U.; Centeno, A.; Mendes, A.F.; Blanco, F.J.; Caramés, B., 2016. Osteoarthritis and Cartilage. 2116 - 2125. 12. 24. 2016. http://dx.doi.org/10.1016/j.joca.2016.06.019 . 10.1016/j.joca.2016.06.019 . Osteoarthritis and Cartilage
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Articular Cartilage Tissue Engineering and Mechanical Stimulation
Mendes, Alexandrina, 2016. Journal of Functional Morphology and Kinesiology. 2016. http://www.mdpi.com/2411-5142/1/2/162 . 10.3390/jfmk1020162 . Journal of Functional Morphology and Kinesiology
The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing
Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . published Nature Reviews Endocrinology
Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation
Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, Cláudia, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://dx.doi.org/10.18632/aging.100996 . 10.18632/aging.100996 . published Aging
Insulin decreases autophagy and leads to cartilage degradation
Ribeiro, M.; López de Figueroa, P.; Blanco, F.J.; Mendes, A.F.; Caramés, B., 2016. Osteoarthritis and Cartilage. 731 - 739. 4. 24. 2016. http://dx.doi.org/10.1016/j.joca.2015.10.017 . 10.1016/j.joca.2015.10.017 . Osteoarthritis and Cartilage
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction
Alexandrina F Mendes; Susana C Rosa; Ana T Rufino; Madalena Ribeiro; Fernando Judas, 2015. BMC Musculoskeletal Disorders. S1. 16. 2015. https://doi.org/10.1186%2F1471-2474-16-s1-s1 . 10.1186/1471-2474-16-s1-s1 . BMC Musculoskeletal Disorders
Tissue Engineered Cartilage in Unconfined Compression: Biomechanical Analysis
Cátia Bandeiras; António Completo; António Ramos; Ana Teresa Rufino; Madalena Ribeiro; João Pinto Ferreira; Alexandrina Ferreira Mendes, 2015. Materials Today: Proceedings. 355 - 364. 1. 2. 2015. https://doi.org/10.1016%2Fj.matpr.2015.04.032 . 10.1016/j.matpr.2015.04.032 . Materials Today: Proceedings
Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis
Mendes, Alexandrina; Rufino, A.T.; Ribeiro, M.; Sousa, C.; Judas, F.; Salgueiro, L.; Cavaleiro, C.; Mendes, A.F., 2015. European Journal of Pharmacology. 141 - 150. 750. 2015. http://www.sciencedirect.com/science/article/pii/S0014299915000412 . http://dx.doi.org/10.1016/j.ejphar.2015.01.018 . European Journal of Pharmacology
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, Magda M.; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico C.; Kaster, Manuella P.; Aveleira, Célia A.; Ferreira, Marisa; Álvaro, Ana Rita; Cavadas, Cláudia, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://dx.doi.org/10.1016/j.euroneuro.2015.06.013 . 10.1016/j.euroneuro.2015.06.013 . published European Neuropsychopharmacology
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?
Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . Autophagy
Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells
Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., 2015. Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . published Neuroscience Letters
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; Álvaro, A.R.; Cavadas, C., 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology
Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases
Rufino, Ana T.; Ferreira, Isabel; Judas, Fernando; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina F., 2015. Pharmaceutical Biology. 1220 - 1230. 8. 53. 2015. http://dx.doi.org/10.3109/13880209.2014.970701 . 10.3109/13880209.2014.970701 . Pharmaceutical Biology
Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach
Mendes, Alexandrina, 2014. PlosOne. 2014. 10.1371/journal.pone.0109048 . PlosOne
Anti-inflammatory and Chondroprotective Activity of (+)-a-Pinene: Structural and Enantiomeric Selectivity
Mendes, Alexandrina, 2014. Journal of Natural Products. 2014. 10.1021/np400828x . Journal of Natural Products
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro
Sousa-Ferreira, L; Aveleira, C.; Botelho, M; Álvaro, Ana Rita Costa Silva; de Almeida, P.L.; Cavadas, C., 2014. PLoS One. eCollection2014 - eCollection2014. 3. 9. 2014. 10.1371/journal.pone.0088917 . published PLoS One
Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress
Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://dx.doi.org/10.1016/j.neuroscience.2014.04.042 . 10.1016/j.neuroscience.2014.04.042 . published Neuroscience
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia, 2014. Progress in Neurobiology. 70 - 79. Jan. 112. 2014. 10.1016/j.pneurobio.2013.10.002 . published Progress in Neurobiology
Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro
Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE
Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture
Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, 2013. Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . published Investigative Opthalmology & Visual Science
Physiology and pathophysiology of musculoskeletal aging: current research trends and future priorities
Mobasheri, Ali; Mendes, Alexandrina F.; Mobasheri, A.; Mendes, A.F., 2013. Frontiers in Physiology. 4. 2013. http://dx.doi.org/10.3389/fphys.2013.00073 . 10.3389/fphys.2013.00073 . Frontiers in Physiology
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease
Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís, 2013. Brain. 2173 - 2188. 7. 136. 2013. http://dx.doi.org/10.1093/brain/awt144 . 10.1093/brain/awt144 . published Brain
Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: Possible role in glucose sensing
Rufino, A.T.; Rosa, S.C.; Judas, F.; Mobasheri, A.; Lopes, M.C.; Mendes, A.F., 2013. Journal of Cellular Biochemistry. 1879 - 1889. 8. 114. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879133940&partnerID=MN8TOARS . 10.1002/jcb.24532 . Journal of Cellular Biochemistry
Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate
Santos-Carvalho, A; Elvas, F; ¿?lvaro, A R; Ambrósio, A F; Cavadas, C., 2013. Cell Death and Disease. e636 - e636. 5. 4. 2013. 10.1038/cddis.2013.160 . published Cell Death and Disease
Potassium channels in articular chondrocytes
Mobasheri, A.; Lewis, R.; Ferreira-Mendes, A.; Rufino, A.; Dart, C.; Barrett-Jolley, R., 2012. Channels. 416 - 425. 6. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871438042&partnerID=MN8TOARS . 10.4161/chan.22340 . Channels
Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity
Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., 2012. PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . published PLoS ONE
Cortical strut allografting in reconstructive orthopaedic surgery
Judas, F.; Saavedra, M.J.; Mendes, A.F.; Dias, R., 2011. Acta Reumatologica Portuguesa. 24 - 28. 1. 36. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955647442&partnerID=MN8TOARS . Acta Reumatologica Portuguesa
Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 19745 - 19745. 5. 6. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21589937 . 10.1371/journal.pone.0019745 . published PLoS ONE
Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats
Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE
Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 5. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0019745 . 10.1371/journal.pone.0019745 . published PLoS ONE
Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin
Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Osteoarthritis and Cartilage. 719 - 727. 6. 19. 2011. 10.1016/j.joca.2011.02.004 . published Osteoarthritis and Cartilage
Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes
Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Journal of Cellular Biochemistry. 2813 - 2824. 10. 112. 2011. 10.1002/jcb.23196 . published Journal of Cellular Biochemistry
High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism
Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, 2010. Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . published Cytokine
TNF- Signals Through PKCz /NF- kB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., 2010. Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . published Diabetes
Screening of Five Essential Oils for Identification of Potential Inhibitors of IL-1-induced Nf-¿B Activation and NO Production in Human Chondrocytes: Characterization of the Inhibitory Activity of a -Pinene
Neves, Ângela; Rosa, Susana C.; Gonçalves, Juliana; Rufino, Ana T.; Judas, Fernando M.; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina Ferreira, 2010. Planta Medica. 303 - 308. 03. 76. 2010. 10.1055/s-0029-1186085 . published Planta Medica
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide
Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; et al, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry
Neuropeptide Y inhibits [Ca 2+]i changes in rat retinal neurons through NPY Y1 , Y4 and Y5 receptors
Álvaro, Ana Rita ; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19344373 . 10.1111/j.1471-4159.2009.06079.x . published Journal of Neurochemistry
Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Osteoarthritis and Cartilage. 1657 - 1661. 12. 17. 2009. 10.1016/j.joca.2009.08.016 . published Osteoarthritis and Cartilage
Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: role of neuropeptide Y and nitric oxide
Rosmaninho-Salgado, Joana; Araújo, Inês M.; ¿?lvaro, Ana Rita; Mendes, Alexandrina Ferreira; Ferreira, Lígia; Grouzmann, Eric; Mota, Alfredo; Duarte, Emília. P.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry
High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., 2009. Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . published Experimental Eye Research
Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Ali Mobasheri; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Arthritis Research & Therapy. 1 - 11. R80. 11. 2009. http://arthritis-research.com/content/11/3/R80 . 10.1186/ar2713 . published Arthritis Research & Therapy
Nitric oxide synthase isoforms and NF-¿B activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide
Rosa, Susana C.; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2008. Nitric Oxide. 276 - 283. 3. 19. 2008. 10.1016/j.niox.2008.07.005 . published Nitric Oxide
Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide
¿?lvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18331583 . 10.1111/j.1471-4159.2008.05334.x . published Journal of Neurochemistry
Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., 2008. Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . published Ocular Immunology and Inflammation
Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A. R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18249070 . 10.1016/j.neuroscience.2007.12.027 . published Neuroscience
Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines.
Mobasheri, A.; Bondy, C.A.; Moley, K.; Mendes, A.F.; Rosa, S.C.; Richardson, S.M.; Hoyland, J.A.; Barrett-Jolley, R.; Shakibaei, M., 2008. Advances in anatomy, embryology, and cell biology. 200. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149170369&partnerID=MN8TOARS . Advances in anatomy, embryology, and cell biology
Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts: Effect of Cryoprotective Agents
Judas, Fernando M.; Rosa, Susana C.; TEIXEIRA, L; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2007. Transplantation Proceedings. 2531 - 2534. 8. 39. 2007. 10.1016/j.transproceed.2007.07.028 . published Transplantation Proceedings
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17353067 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells
Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Duarte, E.P.; Cavadas, C.; Álvaro, A.R., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . published Journal of Neurochemistry
Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells
Rosmaninho-Salgado, Joana; ¿?lvaro, Ana Rita; Grouzmann, Eric; Duarte, Emilia P.; Cavadas, Cláudia, 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17207896 . 10.1016/j.peptides.2006.11.015 . published Peptides
Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization
Moreno, António J.; Oliveira, Paulo J.; Nova, Carlos D.; ¿?lvaro, Ana R.; Moreira, Renata A.; Santos, Sandra M. D.; Macedo, Tice, 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17427176 . 10.1002/jbt.20159 . published Journal of Biochemical and Molecular Toxicology
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK
Castro-caldas, M.; Mendes, Alexandrina Ferreira; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 329 - 337. 6. 12. 2003. 10.1080/09629350310001633351 . published Mediators of Inflammation
Dexamethasone prevents interleukin-1ß-induced nuclear factor-¿B activation by upregulating I¿B-a synthesis, in lymphoblastic cells
Castro-caldas, M.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 37 - 46. 1. 12. 2003. 10.1080/0962935031000096953 . published Mediators of Inflammation
Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular chondrocytes: Implications for the regulation of iNOS expression
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Cell Biology and Toxicology. 203 - 214. 4. 19. 2003. 10.1023/B:CBTO.0000003730.21261.fa . published Cell Biology and Toxicology
Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Journal of Cellular Biochemistry. 783 - 793. 4. 88. 2003. 10.1002/jcb.10428 . published Journal of Cellular Biochemistry
Diacerhein and Rhein Prevent Interleukin-1beta-Induced Nuclear Factor-kappaB Activation by Inhibiting the Degradation of Inhibitor kappaB-alpha
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Pharmacology and Toxicology. 22 - 28. 1. 91. 2002. 10.1034/j.1600-0773.2002.910104.x . published Pharmacology and Toxicology
Role of nitric oxide in the activation of NF-¿B, AP-1 and NOS II expression in articular chondrocytes
Mendes, A.F.; Carvalho, A.P.; Caramona, M.M.; Lopes, M.C.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2002. Inflammation Research. 369 - 375. 7. 51. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036019462&partnerID=MN8TOARS . 10.1007/PL00000317 . published Inflammation Research
Role of Mitogen-Activated Protein Kinases and Tyrosine Kinases on IL-1-Induced NF-¿B Activation and iNOS Expression in Bovine Articular Chondrocytes
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Nitric Oxide. 35 - 44. 1. 6. 2002. 10.1006/niox.2001.0378 . published Nitric Oxide
Diphenyleneiodonium inhibits NF-¿B activation and iNOS expression induced by IL-1ß: involvement of reactive oxygen species
Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2001. Mediators of Inflammation. 209 - 215. 4. 10. 2001. 10.1080/09629350120080401 . published Mediators of Inflammation
Changes in the subcellular distribution of the rat uterus oestrogen receptor as induced by oestradiol, tamoxifen and ZD 182, 780
Ferreira Mendes, A.; Caramona, M.M.; Celeste Lopes, M., 1996. Journal of Pharmacy and Pharmacology. 302 - 305. 3. 48. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029891372&partnerID=MN8TOARS . Journal of Pharmacy and Pharmacology
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