Química Medicinal e Descoberta de Fármacos

Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment

Carreira, Laura D.; Oliveira, Rita I.; Moreira, Vânia M.; Salvador, Jorge A. R., 2023. Expert Opinion on Therapeutic Targets. 1043 - 1058. 11. 27. 2023. http://dx.doi.org/10.1080/14728222.2023.2266571 . 10.1080/14728222.2023.2266571 . Expert Opinion on Therapeutic Targets

New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies

Guedes, Romina A.; Grilo, Jorge H.; Carvalho, Andreia N.; Fernandes, Pedro M. P.; Ressurreição, Ana S.; Brito, Vanessa; Santos, Adriana O.; et al, 2023. Pharmaceuticals. 8. 16. 2023. http://dx.doi.org/10.3390/ph16081096 . 10.3390/ph16081096 . Pharmaceuticals

Artificial intelligence for prediction of biological activities and generation of molecular hits using stereochemical information

Pereira, Tiago O.; Abbasi, Maryam; Oliveira, Rita I.; Guedes, Romina A.; Salvador, Jorge A. R.; Arrais, Joel P., 2023. Journal of Computer-Aided Molecular Design. 791 - 806. 12. 37. 2023. http://dx.doi.org/10.1007/s10822-023-00539-9 . 10.1007/s10822-023-00539-9 . Journal of Computer-Aided Molecular Design

Therapeutic potential of glutaminyl cyclases: Current status and emerging trends

Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R., 2023. Drug Discovery Today. 10. 28. 2023. http://dx.doi.org/10.1016/j.drudis.2023.103644 . 10.1016/j.drudis.2023.103644 . Drug Discovery Today

Proteolysis-Targeting Chimeras (PROTACs) targeting the BCR-ABL for the treatment of Chronic Myeloid Leukemia – A Patent Review

André T. S. Vicente; Jorge A. R. Salvador, 2023. Expert Opinion On Therapeutic Patents. 397 - 420. 2023. https://doi.org/10.1080/13543776.2023.2240025 . published Expert Opinion On Therapeutic Patents

Recent advances in oridonin derivatives with anticancer activity

Sobral, Pedro J. M.; Vicente, André T. S.; Salvador, Jorge A. R., 2023. Frontiers in Chemistry. 11. 2023. http://dx.doi.org/10.3389/fchem.2023.1066280 . 10.3389/fchem.2023.1066280 . Frontiers in Chemistry

Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents

Gonçalves, Bruno M. F.; Mendes, Vanessa I. S.; Silvestre, Samuel M.; Salvador, Jorge A. R., 2023. RSC Medicinal Chemistry. 2023. http://dx.doi.org/10.1039/d2md00275b . 10.1039/d2md00275b . RSC Medicinal Chemistry

Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance

Leonardo-Sousa, Carlota; Carvalho, Andreia Neves; Guedes, Romina A.; Fernandes, Pedro M. P.; Aniceto, Natália; Salvador, Jorge A. R.; Gama, Maria João; Guedes, Rita C., 2022. Molecules. 7. 27. 2022. http://dx.doi.org/10.3390/molecules27072201 . 10.3390/molecules27072201 . Molecules

Deep generative model for therapeutic targets using transcriptomic disease-associated data—USP7 case study

Pereira, Tiago; Abbasi, Maryam; Oliveira, Rita I; Guedes, Romina A; Salvador, Jorge A R; Arrais, Joel P, 2022. Briefings in Bioinformatics. 4. 23. 2022. http://dx.doi.org/10.1093/bib/bbac270 . 10.1093/bib/bbac270 . Briefings in Bioinformatics

MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment

Vicente, André T. S.; Salvador, Jorge A. R., 2022. International Journal of Molecular Sciences. 19. 23. 2022. http://dx.doi.org/10.3390/ijms231911068 . 10.3390/ijms231911068 . International Journal of Molecular Sciences

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

Acúrcio, Rita C.; Pozzi, Sabina; Carreira, Barbara; Pojo, Marta; Gómez-Cebrián, Nuria; Casimiro, Sandra; Fernandes, Adelaide; et al, 2022. Journal for ImmunoTherapy of Cancer. 7. 10. 2022. http://dx.doi.org/10.1136/jitc-2022-004695 . 10.1136/jitc-2022-004695 . Journal for ImmunoTherapy of Cancer

Highlights in USP7 inhibitors for cancer treatment

Oliveira, Rita I.; Guedes, Romina A.; Salvador, Jorge A. R., 2022. Frontiers in Chemistry. 10. 2022. http://dx.doi.org/10.3389/fchem.2022.1005727 . 10.3389/fchem.2022.1005727 . Frontiers in Chemistry

A patent review of glutaminyl cyclase inhibitors (2004–present)

Coimbra, Judite R.M.; Salvador, Jorge A.R., 2021. Expert Opinion on Therapeutic Patents. 809 - 836. 9. 31. 2021. http://dx.doi.org/10.1080/13543776.2021.1917549 . 10.1080/13543776.2021.1917549 . Expert Opinion on Therapeutic Patents

Editorial: Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics

Kok, Victor C.; Yu, Cheng-Chia; Salvador, Jorge A.R., 2021. Frontiers in Oncology. 11. 2021. http://dx.doi.org/10.3389/fonc.2021.666103 . 10.3389/fonc.2021.666103 . published Frontiers in Oncology

Glossário de Termos Usados em Química Medicinal

Rui Moreira; M. Matilde Marques; Emília Sousa; Madalena Pinto; Jorge Salvador, 2020. Boletim da Sociedade Portuguesa de Química. 2020. http://dx.doi.org/10.52590/m3.p693.a30002302 . 10.52590/m3.p693.a30002302 . Boletim da Sociedade Portuguesa de Química

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes 7

Gütschow, Michael; Vanden Eynde, Jean Jacques; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; et al, 2020. Molecules. 13. 25. 2020. http://dx.doi.org/10.3390/molecules25132968 . 10.3390/molecules25132968 . Molecules

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, 2020. Journal of Alzheimer's Disease. 1 - 21. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . Journal of Alzheimer's Disease

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

Valdeira, Ana S. C.; Darvishi, Emad; Woldemichael, Girma M.; Beutler, John A.; Gustafson, Kirk R.; Salvador, Jorge A. R., 2019. Journal of Natural Products. 2094 - 2105. 8. 82. 2019. http://dx.doi.org/10.1021/acs.jnatprod.8b00864 . 10.1021/acs.jnatprod.8b00864 . Journal of Natural Products

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Alho, Daniela; Salvador, Jorge; Cascante, Marta; Marin, Silvia, 2019. Molecules. 4. 24. 2019. http://dx.doi.org/10.3390/molecules24040766 . 10.3390/molecules24040766 . Molecules

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

Alho, Daniela P.S.; Salvador, Jorge A.R.; Cascante, Marta; Marin, Silvia, 2019. Molecules. 16. 24. 2019. http://dx.doi.org/10.3390/molecules24162938 . 10.3390/molecules24162938 . Molecules

Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition

Acúrcio, Rita C.; Leonardo-Sousa, Carlota; García-Sosa, Alfonso T.; Salvador, Jorge A.; Florindo, Helena F.; Guedes, Rita C., 2019. MedChemComm. 1810 - 1818. 10. 10. 2019. http://dx.doi.org/10.1039/c9md00326f . 10.1039/c9md00326f . MedChemComm

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design

Guedes, R.; Aniceto; Andrade; Salvador, J.A.R., 2019. International Journal of Molecular Sciences. 21. 20. 2019. http://dx.doi.org/10.3390/ijms20215326 . 10.3390/ijms20215326 . International Journal of Molecular Sciences

An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease

Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity

Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al, 2019. European Journal of Medicinal Chemistry. 184. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.111752 . 10.1016/j.ejmech.2019.111752 . European Journal of Medicinal Chemistry

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R., 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00178 . 10.3389/fchem.2018.00178 . Frontiers in Chemistry

Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy

Acúrcio, Rita C.; Scomparin, Anna; Conniot, João; Salvador, Jorge A. R.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Guedes, Rita C., 2018. Journal of Medicinal Chemistry. 10957 - 10975. 24. 61. 2018. http://dx.doi.org/10.1021/acs.jmedchem.8b00541 . 10.1021/acs.jmedchem.8b00541 . Journal of Medicinal Chemistry

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Valdeira, Ana S. C.; Ritt, Daniel A.; Morrison, Deborah K.; McMahon, James B.; Gustafson, Kirk R.; Salvador JAR (1112-4DB1-C082), 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00434 . 10.3389/fchem.2018.00434 . Frontiers in Chemistry

Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds

Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M., 2017. European Journal of Medicinal Chemistry. 836 - 848. 139. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028462538&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.08.058 . European Journal of Medicinal Chemistry

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Salvador, J.A.R.; Leal, A.S.; Valdeira, A.S.; Gonçalves, B.M.F.; Alho, D.P.S.; Figueiredo, S.A.C.; Silvestre, S.M.; Mendes, V.I.S., 2017. European Journal of Medicinal Chemistry. 95 - 130. 142. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025822828&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.07.013 . European Journal of Medicinal Chemistry

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation

Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M., 2017. European Journal of Medicinal Chemistry. 422 - 437. 138. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021775494&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.06.029 . European Journal of Medicinal Chemistry

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach

Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R., 2017. PLOS ONE. 1. 12. 2017. http://dx.doi.org/10.1371/journal.pone.0170846 . 10.1371/journal.pone.0170846 . PLOS ONE

Design, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents

Gonçalves, B.M.F.; Salvador, J.A.R.; Santos, D.S.M.; Marín, S.; Cascante, M., 2016. RSC Advances. 39296 - 39309. 45. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968807179&partnerID=MN8TOARS . 10.1039/c6ra04597a . RSC Advances

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells

Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R., 2016. European Journal of Medicinal Chemistry. 317 - 331. 123. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979776393&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.07.045 . European Journal of Medicinal Chemistry

Erratum: Corrigendum to “Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells” (European Journal of Medicinal Chemistry (2016) 123 (317–331) (S0223523416306067) (10.1016/j.ejmech.2016.07.045))

Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R., 2016. European Journal of Medicinal Chemistry. 1004 - 1005. 124. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992431127&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.09.088 . European Journal of Medicinal Chemistry

Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity

Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2016. RSC Advances. 3967 - 3985. 5. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954305589&partnerID=MN8TOARS . 10.1039/c5ra19120c . RSC Advances

Computational approaches for the discovery of human proteasome inhibitors: An overview

Guedes, R.A.; Serra, P.; Salvador, J.A.R.; Guedes, R.C., 2016. Molecules. 7. 21. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979205213&partnerID=MN8TOARS . 10.3390/molecules21070927 . Molecules

Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives

Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2016. European Journal of Medicinal Chemistry. 101 - 117. 114. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964200014&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.02.057 . European Journal of Medicinal Chemistry

Starbon®400-HSO<inf>3</inf>: A green mesoporous carbonaceous solid acid catalyst for the Ritter reaction

Mesquita, L.M.M.; Pinto, R.M.A.; Salvador, J.A.R.; Clark, J.H.; Budarin, V.L., 2015. Catalysis Communications. 170 - 173. 69. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933040279&partnerID=MN8TOARS . 10.1016/j.catcom.2015.06.010 . Catalysis Communications

Synthesis of chiral hexacyclic steroids via [8p + 2p] cycloaddition of diazafulvenium methides

Lopes, S.M.M.; Correia, C.F.O.; Nunes, S.C.C.; Pereira, N.A.M.; Ferreira, A.R.F.; Sousa, E.P.; Gomes, C.S.B.; et al, 2015. Organic and Biomolecular Chemistry. 9127 - 9139. 34. 13. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939605321&partnerID=MN8TOARS . 10.1039/c5ob01110h . Organic and Biomolecular Chemistry

Pharmaceutical Green Chemistry Applied to the Chemical Synthesis of Steroid Compounds

Salvador, Jorge; Pinto, Rui; Silvestre, Samuel, 2015. Current Green Chemistry. 97 - 134. 2. 2. 2015. http://dx.doi.org/10.2174/2213346101666140915212302 . 10.2174/2213346101666140915212302 . Current Green Chemistry

Antitumor effects of celastrol and semi-synthetic derivatives

Salvador, J.A.R.; Santos, R.C.; Figueiredo, S.A.C.; Jing, Y., 2014. Mini-Reviews in Organic Chemistry. 400 - 407. 3. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911413424&partnerID=MN8TOARS . Mini-Reviews in Organic Chemistry

Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: Synergistic effects with miltefosine

Sousa, M.C.; Varandas, R.; Santos, R.C.; Santos-Rosa, M.; Alves, V.; Salvador, J.A.R., 2014. PLoS ONE. 3. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898670704&partnerID=MN8TOARS . 10.1371/journal.pone.0089939 . PLoS ONE

Novel oleanolic vinyl boronates: Synthesis and antitumor activity

Moreira, V.M.; Salvador, J.A.R.; Simões, S.; Destro, F.; Gavioli, R., 2013. European Journal of Medicinal Chemistry. 46 - 56. 63. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878527939&partnerID=MN8TOARS . 10.1016/j.ejmech.2013.01.040 . European Journal of Medicinal Chemistry

Steroidal 5a-reductase and 17a-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases

Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M., 2013. Journal of Steroid Biochemistry and Molecular Biology. 199 - 222. 137. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886716946&partnerID=MN8TOARS . 10.1016/j.jsbmb.2013.04.006 . Journal of Steroid Biochemistry and Molecular Biology

Anticancer steroids: Linking natural and semi-synthetic compounds

Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L., 2013. Natural Product Reports. 324 - 374. 2. 30. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS . 10.1039/c2np20082a . Natural Product Reports

Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2013. Organic and Biomolecular Chemistry. 1726 - 1738. 10. 11. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874077386&partnerID=MN8TOARS . 10.1039/c3ob00011g . Organic and Biomolecular Chemistry

Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2012. Bioorganic and Medicinal Chemistry. 5774 - 5786. 19. 20. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866355871&partnerID=MN8TOARS . 10.1016/j.bmc.2012.08.010 . Bioorganic and Medicinal Chemistry

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives

Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Paixão, J.A., 2012. Beilstein Journal of Organic Chemistry. 164 - 169. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856902762&partnerID=MN8TOARS . 10.3762/bjoc.8.17 . Beilstein Journal of Organic Chemistry

Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2012. ChemMedChem. 1635 - 1646. 9. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865591129&partnerID=MN8TOARS . 10.1002/cmdc.201200282 . ChemMedChem

Bismuth compounds in medicinal chemistry

Salvador, J.A.; Figueiredo, S.A.; Pinto, R.M.; Silvestre, S.M., 2012. Future Medicinal Chemistry. 1495 - 1523. 11. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864659112&partnerID=MN8TOARS . 10.4155/fmc.12.95 . Future Medicinal Chemistry

Recent developments in oxidative processes in steroid chemistry

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2012. Current Organic Chemistry. 1243 - 1276. 10. 16. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861178831&partnerID=MN8TOARS . 10.2174/138527212800564204 . Current Organic Chemistry

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.

Salvador, J.A.; Moreira, V.M.; Gonçalves, B.M.; Leal, A.S.; Jing, Y., 2012. Natural product reports. 1463 - 1479. 12. 29. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872769330&partnerID=MN8TOARS . Natural product reports

New applications for bismuth(III) salts in organic synthesis: From bulk chemicals to steroid and terpene chemistry

Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.; Santos, R.C.; Leroux, C., 2012. Topics in Current Chemistry. 143 - 177. 311. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856185934&partnerID=MN8TOARS . 10.1007/128_2011_170 . Topics in Current Chemistry

Bismuth(III) reagents in steroid and terpene chemistry

Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A., 2011. Molecules. 2884 - 2913. 4. 16. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955528110&partnerID=MN8TOARS . 10.3390/molecules16042884 . Molecules

C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells

Moreira, V.M.A.; Salvador, J.A.R.; Matos Beja, A.; Paixão, J.A.; Vasaitis, T.S.; Njar, V.C.O., 2011. European Journal of Pharmaceutical Sciences. 1 - 204. 44. 2011. http://dx.doi.org/10.1016/j.ejps.2011.08.002 . 10.1016/j.ejps.2011.08.002 . European Journal of Pharmaceutical Sciences

New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

Santos, R.C.; Salvador, J.A.R.; Cortés, R.; Pachón, G.; Marín, S.; Cascante, M., 2011. Biochimie. 1065 - 1075. 6. 93. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955054133&partnerID=MN8TOARS . 10.1016/j.biochi.2011.02.014 . Biochimie

Bismuth(III) triflate-based catalytic direct opening of oleanolic hydroxy-¿-lactones to afford 12-oxo-28-carboxylic acids

Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Le Roux, C., 2011. Advanced Synthesis and Catalysis. 2637 - 2642. 14-15. 353. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054739831&partnerID=MN8TOARS . 10.1002/adsc.201100155 . Advanced Synthesis and Catalysis

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3ß- yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17- oxoandrostanes

Moreira, V.M.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A., 2011. Steroids. 582 - 587. 6. 76. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954588573&partnerID=MN8TOARS . 10.1016/j.steroids.2011.02.009 . Steroids

3¿-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate

Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 11. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650948724&partnerID=MN8TOARS . 10.1107/S1600536810043515 . Acta Crystallographica Section E: Structure Reports Online

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P., 2010. Bioorganic and Medicinal Chemistry. 4385 - 4396. 12. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS . 10.1016/j.bmc.2010.04.085 . Bioorganic and Medicinal Chemistry

3-Oxo-18a-olean-28,13ß-olide

Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 8. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956829330&partnerID=MN8TOARS . 10.1107/S160053681002903X . Acta Crystallographica Section E: Structure Reports Online

3ß-Hydroxylup-20(29)-en-28-yl 1H-imidazole-1-carboxylate

Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 7. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954408228&partnerID=MN8TOARS . 10.1107/S160053681002489X . Acta Crystallographica Section E: Structure Reports Online

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta, 2010. Drugs of the Future. 246 - 247. 35. 2010. http://dx.doi.org/10.1016/j.bmc.2009.07.050 . 10.1016/j.bmc.2009.07.050 . Drugs of the Future

Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta; Moreira, João N.; Dinis, Teresa C.P., 2010. Drugs of the Future. 240 - 241. 35. 2010. http://dx.doi.org/10.1016/j.bmc.2010.04.085 . 10.1016/j.bmc.2010.04.085 . Drugs of the Future

Recent advances of nismuth(III) salts in organic chemistry: Application to the synthesis of heterocycles of pharmaceutical interest

Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M., 2009. Current Organic Synthesis. 426 - 470. 4. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350110620&partnerID=MN8TOARS . 10.2174/157017909789108701 . Current Organic Synthesis

19¿,28-Epoxy-18a-olean-3¿-ol

Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section E: Structure Reports Online. 9. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70249125089&partnerID=MN8TOARS . 10.1107/S1600536809030311 . Acta Crystallographica Section E: Structure Reports Online

Bismuth(III) triflate-catalyzed rearrangement of 16a,17a-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16a-substituted 17a-alkyl-17ß-methyl-¿13-18-norsteroids

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Beja, A.M.; Paixão, J.A., 2009. Tetrahedron. 6169 - 6178. 31. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649513263&partnerID=MN8TOARS . 10.1016/j.tet.2009.05.043 . Tetrahedron

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2009. Bioorganic and Medicinal Chemistry. 6241 - 6250. 17. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68649104244&partnerID=MN8TOARS . 10.1016/j.bmc.2009.07.050 . Bioorganic and Medicinal Chemistry

Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Paixão, J.A., 2009. Journal of Organic Chemistry. 8488 - 8491. 21. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350736011&partnerID=MN8TOARS . 10.1021/jo9018478 . Journal of Organic Chemistry

3-Oxoandrosta-4,6-dien-17ß-yl 2-methyl-1H-imidazole-1-carboxylate and 3-oxo-5-androst-17ß-yl 2-methyl-1H-imidazole-1-carboxyl-ate: C - H¿p and p-p Inter-molecular interactions

Ramos Silva, M.; Moreira, V.M.; Cardoso, C.; Beja, A.M.; Salvador, J.A.R., 2009. Acta Crystallographica Section C: Crystal Structure Communications. 3. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62149118592&partnerID=MN8TOARS . 10.1107/S0108270109003278 . Acta Crystallographica Section C: Crystal Structure Communications

16,17-Ep-oxy-5-hydr-oxy-6¿-nitrooxy-20-oxopregnan-3¿-yl acetate

Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section E: Structure Reports Online. 6. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649854870&partnerID=MN8TOARS . 10.1107/S1600536809016997 . Acta Crystallographica Section E: Structure Reports Online

Bismuth triflate-catalyzed Wagner-Meerwein rearrangement in terpenes. Application to the synthesis of the 18a-oleanane core and A-neo-18a-oleanene compounds from lupanes

Salvador, J.A.R.; Pinto, R.M.A.; Santos, R.C.; Le Roux, C.; Beja, A.M.; Paixão, J.A., 2009. Organic and Biomolecular Chemistry. 508 - 517. 3. 7. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849131044&partnerID=MN8TOARS . 10.1039/b814448f . Organic and Biomolecular Chemistry

6¿-Hydr-oxy-5¿-methyl-20-oxo-19-norpregn-9(10)-en-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section C: Crystal Structure Communications. 5. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549162802&partnerID=MN8TOARS . 10.1107/S0108270109010233 . Acta Crystallographica Section C: Crystal Structure Communications

Recent advances of bismuth(III) salts in organic chemistry: Application to the synthesis of aliphatics, alicyclics, aromatics, amino acids and peptides, terpenes and steroids of pharmaceutical interest

Salvador, J.A.R.; Ppinto, R.M.A.; Silvestre, S.M., 2009. Mini-Reviews in Organic Chemistry. 241 - 274. 4. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350227226&partnerID=MN8TOARS . 10.2174/157019309789371587 . Mini-Reviews in Organic Chemistry

Conformation of 17-chloro-16-formylandrosta-5,16-dien-3¿-yl acetate and 17-chloroandrosta-5,16-dien-3¿-yl acetate

Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 9. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51049095681&partnerID=MN8TOARS . 10.1107/S0108270108025997 . Acta Crystallographica Section C: Crystal Structure Communications

CYP17 inhibitors for prostate cancer treatment - An update

Moreira, V.M.; Salvador, J.A.R.; Vasaitis, T.S.; Njar, V.C.O., 2008. Current Medicinal Chemistry. 868 - 899. 9. 15. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44349099797&partnerID=MN8TOARS . 10.2174/092986708783955428 . Current Medicinal Chemistry

5¿,6¿-Ep-oxy-17-oxoandrostan-3¿-yl acetate and 5¿,6¿-ep-oxy-20-oxo-pregnan-3¿-yl acetate

Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 5. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149091878&partnerID=MN8TOARS . 10.1107/S0108270108009621 . Acta Crystallographica Section C: Crystal Structure Communications

Bismuth(III) salt-catalyzed Westphalen and "backbone" rearrangements of 5ß,6ß-epoxysteroids. Synthesis and structural elucidation of new olefinic 19-nor and 18,19-dinorsteroids

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Silva, M.R.; Beja, A.M.; Paixão, J.A., 2008. Steroids. 549 - 561. 5. 73. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649099519&partnerID=MN8TOARS . 10.1016/j.steroids.2008.01.006 . Steroids

Metal triflates combined with caffeine based imidazolium salts: A new family of highly efficient and reusable catalysts

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2008. Catalysis Communications. 465 - 469. 3. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549069243&partnerID=MN8TOARS . 10.1016/j.catcom.2007.07.022 . Catalysis Communications

Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of ß-alkoxy alcohols

Leitão, A.J.L.; Salvador, J.A.R.; Pinto, R.M.A.; Sá e Melo, M.L., 2008. Tetrahedron Letters. 1694 - 1697. 10. 49. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949187114&partnerID=MN8TOARS . 10.1016/j.tetlet.2007.12.121 . Tetrahedron Letters

1H-Indazole and 2H-indazole derivatives of androsta-5,16-dien-3¿-ol

Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 4. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849150404&partnerID=MN8TOARS . 10.1107/S0108270108005842 . Acta Crystallographica Section C: Crystal Structure Communications

6¿-Chloro-5-hydroxy-20-oxopregnan-3¿-yl acetate

Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M., 2008. Acta Crystallographica Section E: Structure Reports Online. 8. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49149110097&partnerID=MN8TOARS . 10.1107/S1600536808019478 . Acta Crystallographica Section E: Structure Reports Online

Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth

Moreira, V.M.A.; Vasaitis, T.S.; Guo, Z.; Njar, V.C.O.; Salvador, J.A.R., 2008. Steroids. 1217 - 1227. 12. 73. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249167090&partnerID=MN8TOARS . 10.1016/j.steroids.2008.05.010 . Steroids

6¿-Acetamido-5-hydroxy-cholestan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2008. Acta Crystallographica Section E: Structure Reports Online. 12. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349122293&partnerID=MN8TOARS . 10.1107/S160053680803568X . Acta Crystallographica Section E: Structure Reports Online

Catalytic epoxidation and syn-dihydroxylation reactions in steroid chemistry

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2008. Current Organic Chemistry. 492 - 522. 6. 12. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449108043&partnerID=MN8TOARS . 10.2174/138527208784083897 . Current Organic Chemistry

5,6¿-Dihydroxy-cholestan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R., 2007. Acta Crystallographica Section E: Structure Reports Online. 5. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649129062&partnerID=MN8TOARS . 10.1107/S1600536807014705 . Acta Crystallographica Section E: Structure Reports Online

Allylic and benzylic oxidation reactions with sodium chlorite

Silvestre, S.M.; Salvador, J.A.R., 2007. Tetrahedron. 2439 - 2445. 11. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846804403&partnerID=MN8TOARS . 10.1016/j.tet.2007.01.012 . Tetrahedron

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Moreira, V.M.A.; Vasaitis, T.S.; Njar, V.C.O.; Salvador, J.A.R., 2007. Steroids. 939 - 948. 14. 72. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349005731&partnerID=MN8TOARS . 10.1016/j.steroids.2007.08.004 . Steroids

5a-Acetamido-6¿-hydroxy-17-oxoandrostan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2007. Acta Crystallographica Section E: Structure Reports Online. 7. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547204638&partnerID=MN8TOARS . 10.1107/S1600536807029893 . Acta Crystallographica Section E: Structure Reports Online

Bismuth(III) salts mediated regioselective ring opening of epoxides: an easy route to halohydrins and ß-hydroxy nitrates

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2007. Tetrahedron. 9221 - 9228. 37. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547515937&partnerID=MN8TOARS . 10.1016/j.tet.2007.06.054 . Tetrahedron

3-Oxoandrost-4-en-17¿-yl 1H-imidazole-1-carboxyl-ate

Ramos Silva, M.; Matos Beja, A.; Moreira, V.M.; Santos, R.C.; Salvador, J.A.R., 2007. Acta Crystallographica Section E: Structure Reports Online. 12. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849032339&partnerID=MN8TOARS . 10.1107/S1600536807057625 . Acta Crystallographica Section E: Structure Reports Online

One-pot, high yield synthesis of a-ketols from ¿5- steroids

Salvador, J.A.R.; Moreira, V.M.; Hanson, J.R.; Carvalho, R.A., 2006. Steroids. 266 - 272. 3. 71. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-32144460142&partnerID=MN8TOARS . 10.1016/j.steroids.2005.11.002 . Steroids

Ritter reaction mediated by bismuth(III) salts: One-step conversion of epoxides into vic-acylamino-hydroxy compounds

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2006. Synlett. 2047 - 2050. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748278524&partnerID=MN8TOARS . 10.1055/s-2006-949608 . Synlett

Catalytic oxidative processes in steroid chemistry: Allylic oxidation, ß-Selective expoxidation, alcohol oxidation and remote functionalization reactions

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2006. Current Organic Chemistry. 2227 - 2257. 17. 10. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750593724&partnerID=MN8TOARS . 10.2174/138527206778742641 . Current Organic Chemistry

Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide

Salvador, J.A.R.; Silvestre, S.M., 2005. Tetrahedron Letters. 2581 - 2584. 15. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244343394&partnerID=MN8TOARS . 10.1016/j.tetlet.2005.02.080 . Tetrahedron Letters

Hydrazine hydrate induced reductive cleavage of a,ß-epoxy ketones: An efficient procedure for the preparation of ß-hydroxy ketones

Salvador, J.A.R.; Leitão, A.J.L.; Sá E Melo, M.L.; Hanson, J.R., 2005. Tetrahedron Letters. 1067 - 1070. 7. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344252059&partnerID=MN8TOARS . 10.1016/j.tetlet.2004.12.103 . Tetrahedron Letters

ß-Selective epoxidation of ¿5-steroids by O 2 using surface functionalised silica supported cobalt catalysts

Silvestre, S.M.; Salvador, J.A.R.; Clark, J.H., 2004. Journal of Molecular Catalysis A: Chemical. 143 - 147. 1. 219. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042797794&partnerID=MN8TOARS . 10.1016/j.molcata.2004.04.034 . Journal of Molecular Catalysis A: Chemical

6ß-Azido-7a-hydroxy-17-oxo-5a-androstan-3ß-yl acetate

Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Beja, A.M.; Silva, M.R.; Gonsalves, A.M.D'A.R., 2004. Acta Crystallographica Section C: Crystal Structure Communications. 9. 60. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-5144230345&partnerID=MN8TOARS . 10.1107/S0108270104011989 . Acta Crystallographica Section C: Crystal Structure Communications

17-Oxo-5a-androst-6-en-3ß-yl acetate

Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.; Rocha Gonsalves, A.M.d'A., 2004. Acta Crystallographica Section C: Crystal Structure Communications. 1. 60. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242265340&partnerID=MN8TOARS . 10.1107/S0108270103026933 . Acta Crystallographica Section C: Crystal Structure Communications

The solid-phase oxidation of steroidal alkenes with potassium permanganate and metal salts

Salvador, J.A.R.; Hanson, J.R., 2004. Journal of Chemical Research. 513 - 516. 8. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644227114&partnerID=MN8TOARS . Journal of Chemical Research

The conformation of the side chain of 21-alkylpregnanes

Hanson, J.R.; Hitchcock, P.B.; Salvador, J.A.R., 2003. Journal of Chemical Research - Part S. 556 - 558. 9. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787610&partnerID=MN8TOARS . Journal of Chemical Research - Part S

The role of metal salts in a solid phase ß-selective epoxidation of ¿5-steroids with potassium permanganate

Salvador, J.A.R.; Hanson, J.R., 2002. Journal of Chemical Research - Part S. 576 - 578. 11. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036867876&partnerID=MN8TOARS . Journal of Chemical Research - Part S

The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using surface functionalised silica supported metal catalysts

Salvador, J.A.R.; Clark, J.H., 2002. Green Chemistry. 352 - 356. 4. 4. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-57249085588&partnerID=MN8TOARS . 10.1039/b201500p . Green Chemistry

Diastereoselective hydroformylation of ¿4-steroids with rhodium-phosphite catalysts

Freixa, Z.; Pereira, M.M.; Bayón, J.Carles; Silva, A.M.S.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.; Ramos, M., 2001. Tetrahedron Asymmetry. 1083 - 1087. 7. 12. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035826557&partnerID=MN8TOARS . 10.1016/S0957-4166(01)00191-4 . Tetrahedron Asymmetry

The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using homogeneous and heterogeneous cobalt acetate

Salvador, J.A.R.; Clark, J.H., 2001. Chemical Communications. 33 - 34. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819394&partnerID=MN8TOARS . Chemical Communications

Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity

Campos Neves, A.S.; Sá E Melo, M.L.; Moreno, M.J.S.M.; Tavares Da Silva, E.J.; Salvador, J.A.R.; Da Costa, S.P.; Martins, R.M.L.M., 1999. Tetrahedron. 3255 - 3264. 11. 55. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033105263&partnerID=MN8TOARS . 10.1016/S0040-4020(98)01138-7 . Tetrahedron

Copper-catalysed allylic oxidation of ¿5-steroids by t-butyl hydroperoxide

Salvador, J.A.R.; E Melo, M.L.Sá.; Campos Neves, A.S., 1997. Tetrahedron Letters. 119 - 122. 1. 38. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342276132&partnerID=MN8TOARS . 10.1016/S0040-4039(96)02231-9 . Tetrahedron Letters

Oxidations with potassium permanganate - Metal sulphates and nitrates. ß-selective epoxidation of ¿5-unsaturated steroids

Salvador, J.A.R.; Sá E Melo, M.L.; Campos Neves, A.S., 1996. Tetrahedron Letters. 687 - 690. 5. 37. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034598&partnerID=MN8TOARS . 10.1016/0040-4039(95)02243-0 . Tetrahedron Letters

Ultrasound assisted oxidations and reductions in steroid synthesis

Sáe Melo, M.L.; Moreno, M.J.S.M.; da Costa, S.C.P.; Salvador, J.A.R.; Neves, A.S.C., 1994. Ultrasonics - Sonochemistry. 1. 1. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028392619&partnerID=MN8TOARS . 10.1016/1350-4177(94)90024-8 . Ultrasonics - Sonochemistry

SC21 ultrasound assisted reactions in steroid synthesis

Sáe Melo, M.L.; Moreno, M.J.S.M.; Pereira da Costa, S.C.; Salvador, J.A.R.; Campos Neves, A.S., 1994. European Journal of Pharmaceutical Sciences. 1-2. 2. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-43949158790&partnerID=MN8TOARS . 10.1016/0928-0987(94)90103-1 . European Journal of Pharmaceutical Sciences

Ultrasound assisted zinc reactions in synthesis. 2. A new Clemmensen-type reduction

Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S., 1993. Tetrahedron Letters. 361 - 362. 2. 34. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027391706&partnerID=MN8TOARS . 10.1016/S0040-4039(00)60588-9 . Tetrahedron Letters

Ultrasound assisted zinc reactions in synthesis. 1. Efficient reduction of enones

Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S., 1993. Tetrahedron Letters. 357 - 360. 2. 34. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027505351&partnerID=MN8TOARS . 10.1016/S0040-4039(00)60587-7 . Tetrahedron Letters