Biotechnology

Medicinal Chemistry and Drug Discovery

Compound Design & Synthesis

Terpenoids

Cancer

Antimicrobial Resistance

Protozoan Infections


Research lines

Rational design, synthesis and biological evaluation of new anticancer drugs

Discovery of new drugs assisted by computer assisted drug discovery (CADD)

Design & synthesis of antimicrobial agents and materials

Molecular characterization of multidrug resistant bacteria and therapeutic strategies

New therapeutic strategies in neglected parasitic diseases

Overview

The aim of our research is to study the medicinal chemistry of the diterpenoids, namely carnosic acid, oridonin and their derivatives, as well as triterpenoids such as  celastrol, madecassic acid, and derivatives and to study the anticancer activity  of these compounds. 

Computer assisted drug discovery (CADD) will be used to support the development of new drugs acting on ubiquitin-proteasome system (UPS) with potent anticancer activity. In addition we have also been involved in studies on pharmacophore and structure-based drug discovery for the rational design of lead compounds inhibitors of BACE1 and Glutaminyl Cyclase for Alzheimer’s disease treatment.

Our research is also devoted to exploring the medicinal chemistry of the diterpenoids, namely the resin acids and their derivatives. We identify hit compounds to drive drug discovery campaigns, chemical probes to study biological processes and devise shorter, more-efficient semi-synthetic routes towards naturally occurring compounds. In addition, we exploit the potential of the diterpenoids in the development of bio-based antimicrobial surfaces.

Additional objectives are to understand in depth at the molecular level the mechanisms of antimicrobial resistance, their incidence and dissemination to pave ways of fighting this huge problem of the present century, namely, to overcome resistance by investigate new therapeutic alternatives and discover novel antibacterials.

Another important topic of interest is to study neglected tropical diseases (NTDs) caused by pathogens parasites Leishmania, Trypanossoma and Giardia lamblia, to understand host-parasite interaction and to discover potential new drugs and therapeutic strategies to treat these infectious diseases.

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

A Patent Review of Glutaminyl Cyclase Inhibitors (2004-present).

Coimbra, Judite RM; Salvador JAR (1112-4DB1-C082), 2021. 2021. accepted

Editorial: Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics

Kok, Victor C.; Yu, Cheng-Chia; Salvador, Jorge A.R., 2021. Frontiers in Oncology. 11. 2021. http://dx.doi.org/10.3389/fonc.2021.666103 . 10.3389/fonc.2021.666103 . published Frontiers in Oncology

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes 7

Gütschow, Michael; Vanden Eynde, Jean Jacques; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; et al, 2020. Molecules. 13. 25. 2020. http://dx.doi.org/10.3390/molecules25132968 . 10.3390/molecules25132968 . Molecules

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, 2020. Journal of Alzheimer's Disease. 1 - 21. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . Journal of Alzheimer's Disease

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

Valdeira, Ana S. C.; Darvishi, Emad; Woldemichael, Girma M.; Beutler, John A.; Gustafson, Kirk R.; Salvador, Jorge A. R., 2019. Journal of Natural Products. 2094 - 2105. 8. 82. 2019. http://dx.doi.org/10.1021/acs.jnatprod.8b00864 . 10.1021/acs.jnatprod.8b00864 . Journal of Natural Products

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Alho, Daniela; Salvador, Jorge; Cascante, Marta; Marin, Silvia, 2019. Molecules. 4. 24. 2019. http://dx.doi.org/10.3390/molecules24040766 . 10.3390/molecules24040766 . Molecules

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

Alho, Daniela P.S.; Salvador, Jorge A.R.; Cascante, Marta; Marin, Silvia, 2019. Molecules. 16. 24. 2019. http://dx.doi.org/10.3390/molecules24162938 . 10.3390/molecules24162938 . Molecules

Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition

Acúrcio, Rita C.; Leonardo-Sousa, Carlota; García-Sosa, Alfonso T.; Salvador, Jorge A.; Florindo, Helena F.; Guedes, Rita C., 2019. MedChemComm. 1810 - 1818. 10. 10. 2019. http://dx.doi.org/10.1039/c9md00326f . 10.1039/c9md00326f . MedChemComm

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design

Guedes, R.; Aniceto; Andrade; Salvador, J.A.R., 2019. International Journal of Molecular Sciences. 21. 20. 2019. http://dx.doi.org/10.3390/ijms20215326 . 10.3390/ijms20215326 . International Journal of Molecular Sciences

An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease

Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity

Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al, 2019. European Journal of Medicinal Chemistry. 184. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.111752 . 10.1016/j.ejmech.2019.111752 . European Journal of Medicinal Chemistry

Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy

Acúrcio, Rita C.; Scomparin, Anna; Conniot, João; Salvador, Jorge A. R.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Guedes, Rita C., 2018. Journal of Medicinal Chemistry. 10957 - 10975. 24. 61. 2018. http://dx.doi.org/10.1021/acs.jmedchem.8b00541 . 10.1021/acs.jmedchem.8b00541 . Journal of Medicinal Chemistry

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Valdeira, Ana S. C.; Ritt, Daniel A.; Morrison, Deborah K.; McMahon, James B.; Gustafson, Kirk R.; Salvador JAR (1112-4DB1-C082), 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00434 . 10.3389/fchem.2018.00434 . Frontiers in Chemistry

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R., 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00178 . 10.3389/fchem.2018.00178 . Frontiers in Chemistry

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation

Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M., 2017. European Journal of Medicinal Chemistry. 422 - 437. 138. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021775494&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.06.029 . European Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds

Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M., 2017. European Journal of Medicinal Chemistry. 836 - 848. 139. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028462538&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.08.058 . European Journal of Medicinal Chemistry

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach

Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R., 2017. PLOS ONE. 1. 12. 2017. http://dx.doi.org/10.1371/journal.pone.0170846 . 10.1371/journal.pone.0170846 . PLOS ONE

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Salvador, J.A.R.; Leal, A.S.; Valdeira, A.S.; Gonçalves, B.M.F.; Alho, D.P.S.; Figueiredo, S.A.C.; Silvestre, S.M.; Mendes, V.I.S., 2017. European Journal of Medicinal Chemistry. 95 - 130. 142. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025822828&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.07.013 . European Journal of Medicinal Chemistry

Computational approaches for the discovery of human proteasome inhibitors: An overview

Guedes, R.A.; Serra, P.; Salvador, J.A.R.; Guedes, R.C., 2016. Molecules. 7. 21. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979205213&partnerID=MN8TOARS . 10.3390/molecules21070927 . Molecules

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells

Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R., 2016. European Journal of Medicinal Chemistry. 317 - 331. 123. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979776393&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.07.045 . European Journal of Medicinal Chemistry

Design, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents

Gonçalves, B.M.F.; Salvador, J.A.R.; Santos, D.S.M.; Marín, S.; Cascante, M., 2016. RSC Advances. 39296 - 39309. 45. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968807179&partnerID=MN8TOARS . 10.1039/c6ra04597a . RSC Advances

Erratum: Corrigendum to “Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells” (European Journal of Medicinal Chemistry (2016) 123 (317–331) (S0223523416306067) (10.1016/j.ejmech.2016.07.045))

Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R., 2016. European Journal of Medicinal Chemistry. 1004 - 1005. 124. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992431127&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.09.088 . European Journal of Medicinal Chemistry

Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity

Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2016. RSC Advances. 3967 - 3985. 5. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954305589&partnerID=MN8TOARS . 10.1039/c5ra19120c . RSC Advances

Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives

Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2016. European Journal of Medicinal Chemistry. 101 - 117. 114. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964200014&partnerID=MN8TOARS . 10.1016/j.ejmech.2016.02.057 . European Journal of Medicinal Chemistry

Pharmaceutical Green Chemistry Applied to the Chemical Synthesis of Steroid Compounds

Salvador, Jorge; Pinto, Rui; Silvestre, Samuel, 2015. Current Green Chemistry. 97 - 134. 2. 2. 2015. http://dx.doi.org/10.2174/2213346101666140915212302 . 10.2174/2213346101666140915212302 . Current Green Chemistry

Synthesis of chiral hexacyclic steroids via [8p + 2p] cycloaddition of diazafulvenium methides

Lopes, S.M.M.; Correia, C.F.O.; Nunes, S.C.C.; Pereira, N.A.M.; Ferreira, A.R.F.; Sousa, E.P.; Gomes, C.S.B.; et al, 2015. Organic and Biomolecular Chemistry. 9127 - 9139. 34. 13. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939605321&partnerID=MN8TOARS . 10.1039/c5ob01110h . Organic and Biomolecular Chemistry

Starbon®400-HSO<inf>3</inf>: A green mesoporous carbonaceous solid acid catalyst for the Ritter reaction

Mesquita, L.M.M.; Pinto, R.M.A.; Salvador, J.A.R.; Clark, J.H.; Budarin, V.L., 2015. Catalysis Communications. 170 - 173. 69. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933040279&partnerID=MN8TOARS . 10.1016/j.catcom.2015.06.010 . Catalysis Communications

Antitumor effects of celastrol and semi-synthetic derivatives

Salvador, J.A.R.; Santos, R.C.; Figueiredo, S.A.C.; Jing, Y., 2014. Mini-Reviews in Organic Chemistry. 400 - 407. 3. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911413424&partnerID=MN8TOARS . Mini-Reviews in Organic Chemistry

Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: Synergistic effects with miltefosine

Sousa, M.C.; Varandas, R.; Santos, R.C.; Santos-Rosa, M.; Alves, V.; Salvador, J.A.R., 2014. PLoS ONE. 3. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898670704&partnerID=MN8TOARS . 10.1371/journal.pone.0089939 . PLoS ONE

Steroidal 5a-reductase and 17a-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases

Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M., 2013. Journal of Steroid Biochemistry and Molecular Biology. 199 - 222. 137. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886716946&partnerID=MN8TOARS . 10.1016/j.jsbmb.2013.04.006 . Journal of Steroid Biochemistry and Molecular Biology

Novel oleanolic vinyl boronates: Synthesis and antitumor activity

Moreira, V.M.; Salvador, J.A.R.; Simões, S.; Destro, F.; Gavioli, R., 2013. European Journal of Medicinal Chemistry. 46 - 56. 63. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878527939&partnerID=MN8TOARS . 10.1016/j.ejmech.2013.01.040 . European Journal of Medicinal Chemistry

Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2013. Organic and Biomolecular Chemistry. 1726 - 1738. 10. 11. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874077386&partnerID=MN8TOARS . 10.1039/c3ob00011g . Organic and Biomolecular Chemistry

Anticancer steroids: Linking natural and semi-synthetic compounds

Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L., 2013. Natural Product Reports. 324 - 374. 2. 30. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS . 10.1039/c2np20082a . Natural Product Reports

New applications for bismuth(III) salts in organic synthesis: From bulk chemicals to steroid and terpene chemistry

Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.; Santos, R.C.; Leroux, C., 2012. Topics in Current Chemistry. 143 - 177. 311. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856185934&partnerID=MN8TOARS . 10.1007/128_2011_170 . Topics in Current Chemistry

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives

Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Paixão, J.A., 2012. Beilstein Journal of Organic Chemistry. 164 - 169. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856902762&partnerID=MN8TOARS . 10.3762/bjoc.8.17 . Beilstein Journal of Organic Chemistry

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.

Salvador, J.A.; Moreira, V.M.; Gonçalves, B.M.; Leal, A.S.; Jing, Y., 2012. Natural product reports. 1463 - 1479. 12. 29. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872769330&partnerID=MN8TOARS . Natural product reports

Recent developments in oxidative processes in steroid chemistry

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2012. Current Organic Chemistry. 1243 - 1276. 10. 16. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861178831&partnerID=MN8TOARS . 10.2174/138527212800564204 . Current Organic Chemistry

Bismuth compounds in medicinal chemistry

Salvador, J.A.; Figueiredo, S.A.; Pinto, R.M.; Silvestre, S.M., 2012. Future Medicinal Chemistry. 1495 - 1523. 11. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864659112&partnerID=MN8TOARS . 10.4155/fmc.12.95 . Future Medicinal Chemistry

Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2012. ChemMedChem. 1635 - 1646. 9. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865591129&partnerID=MN8TOARS . 10.1002/cmdc.201200282 . ChemMedChem

Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells

Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y., 2012. Bioorganic and Medicinal Chemistry. 5774 - 5786. 19. 20. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866355871&partnerID=MN8TOARS . 10.1016/j.bmc.2012.08.010 . Bioorganic and Medicinal Chemistry

C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells

Moreira, V.M.A.; Salvador, J.A.R.; Matos Beja, A.; Paixão, J.A.; Vasaitis, T.S.; Njar, V.C.O., 2011. European Journal of Pharmaceutical Sciences. 1 - 204. 44. 2011. http://dx.doi.org/10.1016/j.ejps.2011.08.002 . 10.1016/j.ejps.2011.08.002 . European Journal of Pharmaceutical Sciences

New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

Santos, R.C.; Salvador, J.A.R.; Cortés, R.; Pachón, G.; Marín, S.; Cascante, M., 2011. Biochimie. 1065 - 1075. 6. 93. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955054133&partnerID=MN8TOARS . 10.1016/j.biochi.2011.02.014 . Biochimie

Bismuth(III) triflate-based catalytic direct opening of oleanolic hydroxy-¿-lactones to afford 12-oxo-28-carboxylic acids

Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Le Roux, C., 2011. Advanced Synthesis and Catalysis. 2637 - 2642. 14-15. 353. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054739831&partnerID=MN8TOARS . 10.1002/adsc.201100155 . Advanced Synthesis and Catalysis

Bismuth(III) reagents in steroid and terpene chemistry

Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A., 2011. Molecules. 2884 - 2913. 4. 16. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955528110&partnerID=MN8TOARS . 10.3390/molecules16042884 . Molecules

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3ß- yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17- oxoandrostanes

Moreira, V.M.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A., 2011. Steroids. 582 - 587. 6. 76. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954588573&partnerID=MN8TOARS . 10.1016/j.steroids.2011.02.009 . Steroids

3¿-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate

Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 11. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650948724&partnerID=MN8TOARS . 10.1107/S1600536810043515 . Acta Crystallographica Section E: Structure Reports Online

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P., 2010. Bioorganic and Medicinal Chemistry. 4385 - 4396. 12. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS . 10.1016/j.bmc.2010.04.085 . Bioorganic and Medicinal Chemistry

3-Oxo-18a-olean-28,13ß-olide

Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 8. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956829330&partnerID=MN8TOARS . 10.1107/S160053681002903X . Acta Crystallographica Section E: Structure Reports Online

3ß-Hydroxylup-20(29)-en-28-yl 1H-imidazole-1-carboxylate

Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2010. Acta Crystallographica Section E: Structure Reports Online. 7. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954408228&partnerID=MN8TOARS . 10.1107/S160053681002489X . Acta Crystallographica Section E: Structure Reports Online

The Multiple Effects of CYP17 Inhibitors on Prostate Cancer Cell.

Moreira, V.M.; Salvador, J.A.R., 2010. Drugs of the Future. 71 - 72. 35. 2010. 10.1177/1758834016642370 . Drugs of the Future

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta, 2010. Drugs of the Future. 246 - 247. 35. 2010. http://dx.doi.org/10.1016/j.bmc.2009.07.050 . 10.1016/j.bmc.2009.07.050 . Drugs of the Future

Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta; Moreira, João N.; Dinis, Teresa C.P., 2010. Drugs of the Future. 240 - 241. 35. 2010. http://dx.doi.org/10.1016/j.bmc.2010.04.085 . 10.1016/j.bmc.2010.04.085 . Drugs of the Future

Recent advances of nismuth(III) salts in organic chemistry: Application to the synthesis of heterocycles of pharmaceutical interest

Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M., 2009. Current Organic Synthesis. 426 - 470. 4. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350110620&partnerID=MN8TOARS . 10.2174/157017909789108701 . Current Organic Synthesis

19¿,28-Epoxy-18a-olean-3¿-ol

Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section E: Structure Reports Online. 9. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70249125089&partnerID=MN8TOARS . 10.1107/S1600536809030311 . Acta Crystallographica Section E: Structure Reports Online

Bismuth(III) triflate-catalyzed rearrangement of 16a,17a-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16a-substituted 17a-alkyl-17ß-methyl-¿13-18-norsteroids

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Beja, A.M.; Paixão, J.A., 2009. Tetrahedron. 6169 - 6178. 31. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649513263&partnerID=MN8TOARS . 10.1016/j.tet.2009.05.043 . Tetrahedron

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M., 2009. Bioorganic and Medicinal Chemistry. 6241 - 6250. 17. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68649104244&partnerID=MN8TOARS . 10.1016/j.bmc.2009.07.050 . Bioorganic and Medicinal Chemistry

Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Paixão, J.A., 2009. Journal of Organic Chemistry. 8488 - 8491. 21. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350736011&partnerID=MN8TOARS . 10.1021/jo9018478 . Journal of Organic Chemistry

3-Oxoandrosta-4,6-dien-17ß-yl 2-methyl-1H-imidazole-1-carboxylate and 3-oxo-5-androst-17ß-yl 2-methyl-1H-imidazole-1-carboxyl-ate: C - H¿p and p-p Inter-molecular interactions

Ramos Silva, M.; Moreira, V.M.; Cardoso, C.; Beja, A.M.; Salvador, J.A.R., 2009. Acta Crystallographica Section C: Crystal Structure Communications. 3. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62149118592&partnerID=MN8TOARS . 10.1107/S0108270109003278 . Acta Crystallographica Section C: Crystal Structure Communications

16,17-Ep-oxy-5-hydr-oxy-6¿-nitrooxy-20-oxopregnan-3¿-yl acetate

Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section E: Structure Reports Online. 6. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649854870&partnerID=MN8TOARS . 10.1107/S1600536809016997 . Acta Crystallographica Section E: Structure Reports Online

Bismuth triflate-catalyzed Wagner-Meerwein rearrangement in terpenes. Application to the synthesis of the 18a-oleanane core and A-neo-18a-oleanene compounds from lupanes

Salvador, J.A.R.; Pinto, R.M.A.; Santos, R.C.; Le Roux, C.; Beja, A.M.; Paixão, J.A., 2009. Organic and Biomolecular Chemistry. 508 - 517. 3. 7. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849131044&partnerID=MN8TOARS . 10.1039/b814448f . Organic and Biomolecular Chemistry

6¿-Hydr-oxy-5¿-methyl-20-oxo-19-norpregn-9(10)-en-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2009. Acta Crystallographica Section C: Crystal Structure Communications. 5. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549162802&partnerID=MN8TOARS . 10.1107/S0108270109010233 . Acta Crystallographica Section C: Crystal Structure Communications

Recent advances of bismuth(III) salts in organic chemistry: Application to the synthesis of aliphatics, alicyclics, aromatics, amino acids and peptides, terpenes and steroids of pharmaceutical interest

Salvador, J.A.R.; Ppinto, R.M.A.; Silvestre, S.M., 2009. Mini-Reviews in Organic Chemistry. 241 - 274. 4. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350227226&partnerID=MN8TOARS . 10.2174/157019309789371587 . Mini-Reviews in Organic Chemistry

Catalytic epoxidation and syn-dihydroxylation reactions in steroid chemistry

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2008. Current Organic Chemistry. 492 - 522. 6. 12. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449108043&partnerID=MN8TOARS . 10.2174/138527208784083897 . Current Organic Chemistry

CYP17 inhibitors for prostate cancer treatment - An update

Moreira, V.M.; Salvador, J.A.R.; Vasaitis, T.S.; Njar, V.C.O., 2008. Current Medicinal Chemistry. 868 - 899. 9. 15. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44349099797&partnerID=MN8TOARS . 10.2174/092986708783955428 . Current Medicinal Chemistry

5¿,6¿-Ep-oxy-17-oxoandrostan-3¿-yl acetate and 5¿,6¿-ep-oxy-20-oxo-pregnan-3¿-yl acetate

Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 5. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149091878&partnerID=MN8TOARS . 10.1107/S0108270108009621 . Acta Crystallographica Section C: Crystal Structure Communications

Bismuth(III) salt-catalyzed Westphalen and "backbone" rearrangements of 5ß,6ß-epoxysteroids. Synthesis and structural elucidation of new olefinic 19-nor and 18,19-dinorsteroids

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Silva, M.R.; Beja, A.M.; Paixão, J.A., 2008. Steroids. 549 - 561. 5. 73. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649099519&partnerID=MN8TOARS . 10.1016/j.steroids.2008.01.006 . Steroids

Metal triflates combined with caffeine based imidazolium salts: A new family of highly efficient and reusable catalysts

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2008. Catalysis Communications. 465 - 469. 3. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549069243&partnerID=MN8TOARS . 10.1016/j.catcom.2007.07.022 . Catalysis Communications

Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of ß-alkoxy alcohols

Leitão, A.J.L.; Salvador, J.A.R.; Pinto, R.M.A.; Sá e Melo, M.L., 2008. Tetrahedron Letters. 1694 - 1697. 10. 49. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949187114&partnerID=MN8TOARS . 10.1016/j.tetlet.2007.12.121 . Tetrahedron Letters

1H-Indazole and 2H-indazole derivatives of androsta-5,16-dien-3¿-ol

Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 4. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849150404&partnerID=MN8TOARS . 10.1107/S0108270108005842 . Acta Crystallographica Section C: Crystal Structure Communications

6¿-Chloro-5-hydroxy-20-oxopregnan-3¿-yl acetate

Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M., 2008. Acta Crystallographica Section E: Structure Reports Online. 8. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49149110097&partnerID=MN8TOARS . 10.1107/S1600536808019478 . Acta Crystallographica Section E: Structure Reports Online

Conformation of 17-chloro-16-formylandrosta-5,16-dien-3¿-yl acetate and 17-chloroandrosta-5,16-dien-3¿-yl acetate

Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R., 2008. Acta Crystallographica Section C: Crystal Structure Communications. 9. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51049095681&partnerID=MN8TOARS . 10.1107/S0108270108025997 . Acta Crystallographica Section C: Crystal Structure Communications

Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth

Moreira, V.M.A.; Vasaitis, T.S.; Guo, Z.; Njar, V.C.O.; Salvador, J.A.R., 2008. Steroids. 1217 - 1227. 12. 73. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249167090&partnerID=MN8TOARS . 10.1016/j.steroids.2008.05.010 . Steroids

6¿-Acetamido-5-hydroxy-cholestan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2008. Acta Crystallographica Section E: Structure Reports Online. 12. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349122293&partnerID=MN8TOARS . 10.1107/S160053680803568X . Acta Crystallographica Section E: Structure Reports Online

Synthesis and Evaluation of Cytotoxic Activity of Novel Synthetic Lupane Derivatives

Sanros R. C.; Cascante, M.; Salvador, J.A.R., 2008. Drugs of the Future. 33. 2008. 10.7324/rjc.2017.1041914 . Drugs of the Future

5,6¿-Dihydroxy-cholestan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R., 2007. Acta Crystallographica Section E: Structure Reports Online. 5. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649129062&partnerID=MN8TOARS . 10.1107/S1600536807014705 . Acta Crystallographica Section E: Structure Reports Online

Allylic and benzylic oxidation reactions with sodium chlorite

Silvestre, S.M.; Salvador, J.A.R., 2007. Tetrahedron. 2439 - 2445. 11. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846804403&partnerID=MN8TOARS . 10.1016/j.tet.2007.01.012 . Tetrahedron

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Moreira, V.M.A.; Vasaitis, T.S.; Njar, V.C.O.; Salvador, J.A.R., 2007. Steroids. 939 - 948. 14. 72. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349005731&partnerID=MN8TOARS . 10.1016/j.steroids.2007.08.004 . Steroids

5a-Acetamido-6¿-hydroxy-17-oxoandrostan-3¿-yl acetate

Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A., 2007. Acta Crystallographica Section E: Structure Reports Online. 7. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547204638&partnerID=MN8TOARS . 10.1107/S1600536807029893 . Acta Crystallographica Section E: Structure Reports Online

Bismuth(III) salts mediated regioselective ring opening of epoxides: an easy route to halohydrins and ß-hydroxy nitrates

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2007. Tetrahedron. 9221 - 9228. 37. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547515937&partnerID=MN8TOARS . 10.1016/j.tet.2007.06.054 . Tetrahedron

3-Oxoandrost-4-en-17¿-yl 1H-imidazole-1-carboxyl-ate

Ramos Silva, M.; Matos Beja, A.; Moreira, V.M.; Santos, R.C.; Salvador, J.A.R., 2007. Acta Crystallographica Section E: Structure Reports Online. 12. 63. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849032339&partnerID=MN8TOARS . 10.1107/S1600536807057625 . Acta Crystallographica Section E: Structure Reports Online

One-pot, high yield synthesis of a-ketols from ¿5- steroids

Salvador, J.A.R.; Moreira, V.M.; Hanson, J.R.; Carvalho, R.A., 2006. Steroids. 266 - 272. 3. 71. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-32144460142&partnerID=MN8TOARS . 10.1016/j.steroids.2005.11.002 . Steroids

Ritter reaction mediated by bismuth(III) salts: One-step conversion of epoxides into vic-acylamino-hydroxy compounds

Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C., 2006. Synlett. 2047 - 2050. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748278524&partnerID=MN8TOARS . 10.1055/s-2006-949608 . Synlett

Catalytic oxidative processes in steroid chemistry: Allylic oxidation, ß-Selective expoxidation, alcohol oxidation and remote functionalization reactions

Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M., 2006. Current Organic Chemistry. 2227 - 2257. 17. 10. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750593724&partnerID=MN8TOARS . 10.2174/138527206778742641 . Current Organic Chemistry

Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide

Salvador, J.A.R.; Silvestre, S.M., 2005. Tetrahedron Letters. 2581 - 2584. 15. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244343394&partnerID=MN8TOARS . 10.1016/j.tetlet.2005.02.080 . Tetrahedron Letters

Hydrazine hydrate induced reductive cleavage of a,ß-epoxy ketones: An efficient procedure for the preparation of ß-hydroxy ketones

Salvador, J.A.R.; Leitão, A.J.L.; Sá E Melo, M.L.; Hanson, J.R., 2005. Tetrahedron Letters. 1067 - 1070. 7. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344252059&partnerID=MN8TOARS . 10.1016/j.tetlet.2004.12.103 . Tetrahedron Letters

New 5b,6b-epoxysteroids with cytotoxic activity

Moreira, V.M.A.; Salvador, J.A.R.; Sá e Melo, M.L.; Hanson, J.R.; Marques, A.; Simões, S., 2005. Sci. Pharm.. 8. 73. 2005. Sci. Pharm.

Synthesis of New Azidosteroids and Related Compounds as Potential Aromatase Inhibitors.

Paixão, J.I.F.; Salvador, J.A.R.; Gonsalves, A.M.d’A R., 2004. Drugs of the Future. 2004. Drugs of the Future

6ß-Azido-7a-hydroxy-17-oxo-5a-androstan-3ß-yl acetate

Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Beja, A.M.; Silva, M.R.; Gonsalves, A.M.D'A.R., 2004. Acta Crystallographica Section C: Crystal Structure Communications. 9. 60. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-5144230345&partnerID=MN8TOARS . 10.1107/S0108270104011989 . Acta Crystallographica Section C: Crystal Structure Communications

ß-Selective epoxidation of ¿5-steroids by O 2 using surface functionalised silica supported cobalt catalysts

Silvestre, S.M.; Salvador, J.A.R.; Clark, J.H., 2004. Journal of Molecular Catalysis A: Chemical. 143 - 147. 1. 219. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042797794&partnerID=MN8TOARS . 10.1016/j.molcata.2004.04.034 . Journal of Molecular Catalysis A: Chemical

The solid-phase oxidation of steroidal alkenes with potassium permanganate and metal salts

Salvador, J.A.R.; Hanson, J.R., 2004. Journal of Chemical Research. 513 - 516. 8. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644227114&partnerID=MN8TOARS . Journal of Chemical Research

17-Oxo-5a-androst-6-en-3ß-yl acetate

Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.; Rocha Gonsalves, A.M.d'A., 2004. Acta Crystallographica Section C: Crystal Structure Communications. 1. 60. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242265340&partnerID=MN8TOARS . 10.1107/S0108270103026933 . Acta Crystallographica Section C: Crystal Structure Communications

The conformation of the side chain of 21-alkylpregnanes

Hanson, J.R.; Hitchcock, P.B.; Salvador, J.A.R., 2003. Journal of Chemical Research - Part S. 556 - 558. 9. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787610&partnerID=MN8TOARS . Journal of Chemical Research - Part S

The role of metal salts in a solid phase ß-selective epoxidation of ¿5-steroids with potassium permanganate

Salvador, J.A.R.; Hanson, J.R., 2002. Journal of Chemical Research - Part S. 576 - 578. 11. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036867876&partnerID=MN8TOARS . Journal of Chemical Research - Part S

The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using surface functionalised silica supported metal catalysts

Salvador, J.A.R.; Clark, J.H., 2002. Green Chemistry. 352 - 356. 4. 4. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-57249085588&partnerID=MN8TOARS . 10.1039/b201500p . Green Chemistry

Diastereoselective hydroformylation of ¿4-steroids with rhodium-phosphite catalysts

Freixa, Z.; Pereira, M.M.; Bayón, J.Carles; Silva, A.M.S.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.; Ramos, M., 2001. Tetrahedron Asymmetry. 1083 - 1087. 7. 12. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035826557&partnerID=MN8TOARS . 10.1016/S0957-4166(01)00191-4 . Tetrahedron Asymmetry

The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using homogeneous and heterogeneous cobalt acetate

Salvador, J.A.R.; Clark, J.H., 2001. Chemical Communications. 33 - 34. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819394&partnerID=MN8TOARS . Chemical Communications

Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity

Campos Neves, A.S.; Sá E Melo, M.L.; Moreno, M.J.S.M.; Tavares Da Silva, E.J.; Salvador, J.A.R.; Da Costa, S.P.; Martins, R.M.L.M., 1999. Tetrahedron. 3255 - 3264. 11. 55. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033105263&partnerID=MN8TOARS . 10.1016/S0040-4020(98)01138-7 . Tetrahedron

Copper-catalysed allylic oxidation of ¿5-steroids by t-butyl hydroperoxide

Salvador, J.A.R.; E Melo, M.L.Sá.; Campos Neves, A.S., 1997. Tetrahedron Letters. 119 - 122. 1. 38. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342276132&partnerID=MN8TOARS . 10.1016/S0040-4039(96)02231-9 . Tetrahedron Letters

Oxidations with potassium permanganate - Metal sulphates and nitrates. ß-selective epoxidation of ¿5-unsaturated steroids

Salvador, J.A.R.; Sá E Melo, M.L.; Campos Neves, A.S., 1996. Tetrahedron Letters. 687 - 690. 5. 37. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034598&partnerID=MN8TOARS . 10.1016/0040-4039(95)02243-0 . Tetrahedron Letters

Ultrasound assisted oxidations and reductions in steroid synthesis

Sáe Melo, M.L.; Moreno, M.J.S.M.; da Costa, S.C.P.; Salvador, J.A.R.; Neves, A.S.C., 1994. Ultrasonics - Sonochemistry. 1. 1. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028392619&partnerID=MN8TOARS . 10.1016/1350-4177(94)90024-8 . Ultrasonics - Sonochemistry

SC21 ultrasound assisted reactions in steroid synthesis

Sáe Melo, M.L.; Moreno, M.J.S.M.; Pereira da Costa, S.C.; Salvador, J.A.R.; Campos Neves, A.S., 1994. European Journal of Pharmaceutical Sciences. 1-2. 2. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-43949158790&partnerID=MN8TOARS . 10.1016/0928-0987(94)90103-1 . European Journal of Pharmaceutical Sciences

Ultrasound assisted zinc reactions in synthesis. 1. Efficient reduction of enones

Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S., 1993. Tetrahedron Letters. 357 - 360. 2. 34. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027505351&partnerID=MN8TOARS . 10.1016/S0040-4039(00)60587-7 . Tetrahedron Letters

Ultrasound assisted zinc reactions in synthesis. 2. A new Clemmensen-type reduction

Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S., 1993. Tetrahedron Letters. 361 - 362. 2. 34. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027391706&partnerID=MN8TOARS . 10.1016/S0040-4039(00)60588-9 . Tetrahedron Letters

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