Vânia Maria Antunes Moreira

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Researcher

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Liquorice for pain?

Bell, Rae F.; Moreira, Vânia M.; Kalso, Eija A.; Yli-Kauhaluoma, Jari, Therapeutic Advances in Psychopharmacology. 11. 2021. http://dx.doi.org/10.1177/20451253211024873 . 10.1177/20451253211024873 . Therapeutic Advances in Psychopharmacology

Precision design of antimicrobial surfaces

Mullen, Declan; Wan, Xing; Takala, Timo; Saris, Per E; Moreira, Vania, Frontiers in Medical Technology. 3. 2021. https://www.frontiersin.org/articles/10.3389/fmedt.2021.640929/full . 10.3389/fmedt.2021.640929 . published Frontiers in Medical Technology

Non-leaching, Highly Biocompatible Nanocellulose Surfaces That Efficiently Resist Fouling by Bacteria in an Artificial Dermis Model

Moreira, Vania, ACS Applied Bio Materials. 2020. http://dx.doi.org/10.1021/acsabm.0c00203 . 10.1021/acsabm.0c00203 . ACS Applied Bio Materials

Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF-¿B activation, and decrease TNF-alpha secretion in primary microglia

Rinne, Maiju; Mätlik, Kert; Ahonen, Tiina; Vedovi, Fabio; Zappia, Giovanni; Moreira, Vânia M.; Yli-Kauhaluoma, Jari; et al, European Journal of Pharmaceutical Sciences. 2020. 10.1016/j.ejps.2020.105493 . European Journal of Pharmaceutical Sciences

Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

Ghada Hassan; Nina Forsman; Xing Wan; Leena Keurulainen; Luis M. Bimbo; Leena-Sisko Johansson; Nina Sipari; et al, ACS Sustainable Chemistry & Engineering. 5002 - 5009. 5. 7. 2019. https://doi.org/10.1021%2Facssuschemeng.8b05658 . 10.1021/acssuschemeng.8b05658 . ACS Sustainable Chemistry & Engineering

Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Ilari Mäki-Opas; Mari Hämäläinen; Lauri J. Moilanen; Raisa Haavikko; Tiina J. Ahonen; Sami Alakurtti; Vânia M. Moreira; et al, ACS Chemical Neuroscience. 2848 - 2857. 10. 2019. https://doi.org/10.1021/acschemneuro.9b00083 . 10.1021/acschemneuro.9b00083 . ACS Chemical Neuroscience

Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A

Tiina J. Ahonen; Juha R. Savinainen; Jari Yli-Kauhaluoma; Eija Kalso; Jarmo T. Laitinen; Vânia M. Moreira, ACS Medicinal Chemistry Letters. 1269 - 1273. 9. 2018. https://doi.org/10.1021/acsmedchemlett.8b00442 . 10.1021/acsmedchemlett.8b00442 . ACS Medicinal Chemistry Letters

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

Laura E. Kolsi; Ana S. Leal; Jari Yli-Kauhaluoma; Karen T. Liby; Vânia M. Moreira, Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-34131-1 . 10.1038/s41598-018-34131-1 . Scientific Reports

Synthesis of 7ß-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors.

Ahonen TJ; Rinne M; Grutschreiber P; Mätlik K; Airavaara M; Schaarschmidt D; Lang H; et al, European journal of medicinal chemistry. 495 - 507. 151. 2018. http://europepmc.org/abstract/med/29649744 . 10.1016/j.ejmech.2018.02.074 . European journal of medicinal chemistry

Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization

Laura E. Kolsi; Jari Yli-Kauhaluoma; Vânia M. Moreira, ACS Omega. 8836 - 8842. 3. 2018. https://doi.org/10.1021/acsomega.8b01401 . 10.1021/acsomega.8b01401 . ACS Omega

Regioselective Benzylic Oxidation of Aromatic Abietanes: Application to the Semisynthesis of the Naturally Occurring Picealactones A, B and C

Kolsi, Laura E.; Krogerus, Sara; Brito, Vanessa; Rüffer, Tobias; Lang, Heinrich; Yli-Kauhaluoma, Jari; Silvestre, Samuel M.; Moreira, Vânia M., ChemistrySelect. 7008 - 7012. 24. 2. 2017. http://dx.doi.org/10.1002/slct.201701477 . 10.1002/slct.201701477 . ChemistrySelect

Antibacterial profiling of abietane-type diterpenoids

Andreas Helfenstein; Mikko Vahermo; Dorota A. Nawrot; Fatih Demirci; Gökalp Iscan; Sara Krogerus; Jari Yli-Kauhaluoma; Vânia M. Moreira; Päivi Tammela, Bioorganic & Medicinal Chemistry. 132 - 137. 1. 25. 2017. https://doi.org/10.1016%2Fj.bmc.2016.10.019 . 10.1016/j.bmc.2016.10.019 . Bioorganic & Medicinal Chemistry

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.

Moreira, Vania, European journal of medicinal chemistry. 2017. http://europepmc.org/abstract/med/29223098 . 10.1016/j.ejmech.2017.11.070 . European journal of medicinal chemistry

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi

Vahermo, Mikko; Krogerus, Sara; Nasereddin, Abdelmajeed; Kaiser, Marcel; Brun, Reto; Jaffe, Charles L.; Yli-Kauhaluoma, Jari; Moreira, Vânia M., MedChemComm. 457 - 463. 3. 7. 2016. http://dx.doi.org/10.1039/c5md00498e . 10.1039/c5md00498e . MedChemComm

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

Pirttimaa M; Nasereddin A; Kopelyanskiy D; Kaiser M; Yli-Kauhaluoma J; Oksman-Caldentey KM; Brun R; et al, Journal of Natural Products. 362 - 368. 79. 2016. http://europepmc.org/abstract/med/26849852 . 10.1021/acs.jnatprod.5b00990 . Journal of Natural Products

Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones

Chaaban, Ibrahim; El Khawass, El Sayeda M.; Abd El Razik, Heba A.; El Salamouni, Nehad S.; Redondo-Horcajo, Mariano; Barasoain, Isabel; Díaz, José Fernando; Yli-Kauhaluoma, Jari; Moreira, Vânia M., Archiv der Pharmazie. 749 - 761. 9. 349. 2016. http://dx.doi.org/10.1002/ardp.201600134 . 10.1002/ardp.201600134 . Archiv der Pharmazie

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo.

Laavola M; Haavikko R; Hämäläinen M; Leppänen T; Nieminen R; Alakurtti S; Moreira VM; Yli-Kauhaluoma J; Moilanen E, Journal of Natural Products. 274 - 280. 79. 2016. http://europepmc.org/abstract/med/26915998 . 10.1021/acs.jnatprod.5b00709 . Journal of Natural Products

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

Härmä V; Haavikko R; Virtanen J; Ahonen I; Schukov HP; Alakurtti S; Purev E; et al, PLoS ONE. 10. 2015. http://europepmc.org/abstract/med/25965345 . 10.1371/journal.pone.0126111 . PLoS ONE

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

Moreira, Vania, European Journal of Medicinal Chemistry. 2015. 10.1016/j.ejmech.2015.07.038 . European Journal of Medicinal Chemistry

Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents

Chaaban, Ibrahim; El Khawass, El Sayeda M.; Abd El Razik, Heba A.; El Salamouni, Nehad S.; Redondo-Horcajo, Mariano; Barasoain, Isabel; Diaz, J. Fernando; Yli-Kauhaluoma, Jari; Moreira, Vania M., European journal of medicinal chemistry. 805 - 13. 87. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25440882&KeyUID=MEDLINE:25440882 . 10.1016/j.ejmech.2014.10.015 . European journal of medicinal chemistry

Isolation and purification of ent-pimara-8(14),15-diene from engineered Aspergillus nidulans by accelerated solvent extraction combined with HPLC

Bromann, K.; Viljanen, K.; Moreira, V. M.; Yli-Kauhaluoma, J.; Ruohonen, L.; Nakari-Setala, T., Analytical Methods. 1227 - 1234. 4. 6. 2014. 10.1039/c3ay41640b . Analytical Methods

Drug repositioning: a machine-learning approach through data integration

Napolitano, Francesco; Zhao, Yan; Moreira, Vania M.; Tagliaferri, Roberto; Kere, Juha; D'Amato, Mauro; Greco, Dario, Journal of Cheminformatics. 5. 2013. 10.1186/1758-2946-5-30 . Journal of Cheminformatics

(+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro.

Fallarero A; Kujala J; Moreira VM; Rajaratnam M; Skogman M; Vuorela P; Yli-Kauhaluoma J, International Journal of Molecular Sciences. 12054 - 12072. 14. 2013. http://europepmc.org/abstract/med/23739682 . 10.3390/ijms140612054 . International Journal of Molecular Sciences

Novel oleanolic vinyl boronates: Synthesis and antitumor activity

Moreira, Vania M.; Salvador, Jorge A. R.; Simoes, Sergio; Destro, Federica; Gavioli, Riccardo, European Journal of Medicinal Chemistry. 46 - 56. 63. 2013. 10.1016/j.ejmech.2013.01.040 . European Journal of Medicinal Chemistry

Ursane-type Pentacyclic Triterpenoids as Useful Platforms in Anticancer Drug Discovery

Jorge A. R. Salvador; Vânia M Moreira; Bruno M. F. Goncalves; Ana S. Leal; Yongkui Jing, Natural Product Reports. 1463 - 1479. 29. 2012. https://tuhat.helsinki.fi/portal/en/publications/ursanetype-pentacyclic-triterpenoids-as-useful-platforms-in-anticancer-drug-discovery(b13fce5b-ae8b-4061-8241-547bb955d72c).html . DOI: 10.1039/c2np20060k . Natural Product Reports

Recent Developments in Oxidative Processes in Steroid Chemistry

Jorge A. R. Salvador; Samuel M. Silvestre; Vânia M Moreira, Current Organic Chemistry. 1243 - 1276. 16. 2012. https://tuhat.helsinki.fi/portal/en/publications/recent-developments-in-oxidative-processes-in-steroid-chemistry(a8852de0-8618-4236-9b1f-513180d22aee).html . Current Organic Chemistry

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives

Salvador, Jorge A R; Moreira, Vânia M; Pinto, Rui M A; Leal, Ana S; Paixão, José A, Beilstein Journal of Organic Chemistry. 164 - 169. 8. 2012. http://dx.doi.org/10.3762/bjoc.8.17 . 10.3762/bjoc.8.17 . Beilstein Journal of Organic Chemistry

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

Salvador, Jorge A. R.; Moreira, Vânia M.; Gonçalves, Bruno M. F.; Leal, Ana S.; Jing, Yongkui, Natural Product Reports. 12. 29. 2012. http://dx.doi.org/10.1039/c2np20060k . 10.1039/c2np20060k . Natural Product Reports

Bismuth(III) Triflate-Based Catalytic Direct Opening of Oleanolic Hydroxy-¿-lactones to Afford 12-Oxo-28-carboxylic Acids

Salvador, Jorge A. R.; Moreira, Vânia M.; Pinto, Rui M. A.; Leal, Ana S.; Le Roux, Christophe, Advanced Synthesis & Catalysis. 2637 - 2642. 14-15. 353. 2011. http://dx.doi.org/10.1002/adsc.201100155 . 10.1002/adsc.201100155 . Advanced Synthesis & Catalysis

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3-yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes.

Vânia M Moreira; Jorge A. R. Salvador; Ana Matos Beja; José A. Paixão, Steroids. 582 - 587. 76. 2011. https://tuhat.helsinki.fi/portal/en/publications/the-reaction-of-azoles-with-17chloro16formylandrosta516dien3ylacetate-synthesis-and-structural-elucidation-of-novel-16azolylmethylene17oxoandrostanes(a90446b3-6fa8-4978-a9ad-8ec23babd79c).html . Steroids

3-Oxoandrosta-4,6-dien-17ß-yl-2'-methyl-1H-imidazole-1-carboxylate and 3-oxo-5a-androst-17ß-yl-2'-methyl-1H-imidazole-1-carboxylate: C—H..p and p•••p intermolecular interactions

Manuela R. Silva; Vânia M Moreira; Cláudia Cardoso; Ana Matos Beja; Jorge A. R. Salvador, Acta Crystallographica. Section C: Crystal Structure Communications. o88 - o91. C65. 2009. https://tuhat.helsinki.fi/portal/en/publications/3oxoandrosta46dien17yl2methyl1himidazole1carboxylate-and-3oxo5androst17yl2methyl1himidazole1carboxylate-ch-and--intermolecular-interactions(1ea6f11e-9a48-4b8c-8bc6-7ad71302f28e).html . Acta Crystallographica. Section C: Crystal Structure Communications

Conformation of 17-Chloro-16-formylandrosta-5,16-dien-3ß-yl acetate and 17-chloroandrosta-5,16-dien-3ß-yl acetate

Manuela R. Silva; Vânia M Moreira; Cláudia Cardoso; Ana Matos Beja; Jorge A. R. Salvador, Acta Crystallographica. Section C: Crystal Structure Communications. o529 - o531. C64. 2008. https://tuhat.helsinki.fi/portal/en/publications/conformation-of-17chloro16formylandrosta516dien3yl-acetate-and-17chloroandrosta516dien3yl-acetate(45726443-19f7-4525-872e-7b74077c3ca8).html . Acta Crystallographica. Section C: Crystal Structure Communications

Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth

Vânia M Moreira; Tadas S. Vasaitis; Zhiyong Guo; Vincent C. O. Njar; Jorge A. R. Salvador, Steroids. 1217 - 1227. 73. 2008. https://tuhat.helsinki.fi/portal/en/publications/synthesis-of-novel-c17-steroidal-carbamates-studies-on-cyp17-action-androgen-receptor-binding-and-function-and-prostate-cancer-cell-growth(cd0fe83e-80a4-4b90-9f5e-405191d0b9fd).html . Steroids

1H-and 2H-indazole derivatives of androsta-5,16-dien-3ß-ol

Manuela R. Silva; Vânia M Moreira; Cláudia Cardoso; Ana M. Beja; Jorge A. R. Salvador, Acta Crystallographica. Section C: Crystal Structure Communications. o217 - o219. C64. 2008. https://tuhat.helsinki.fi/portal/en/publications/1hand-2hindazole-derivatives-of-androsta516dien3ol(f0269b22-19c2-4eab-b0e8-f5d83f24cb8a).html . Acta Crystallographica. Section C: Crystal Structure Communications

Catalytic Epoxidation and syn-Dihydroxylation Reactions in Steroid Chemistry

Jorge A. R. Salvador; Samuel M. Silvestre; Vânia M Moreira, Current Organic Chemistry. 492 - 522. 12. 2008. https://tuhat.helsinki.fi/portal/en/publications/catalytic-epoxidation-and-syndihydroxylation-reactions-in-steroid-chemistry(05696b6a-b98d-4570-93e5-e1f404995b4b).html . Current Organic Chemistry

CYP17 Inhibitors for Prostate Cancer Treatment – An Update

Moreira, V.; Salvador, J.; Vasaitis, T.; Njar, V., Current Medicinal Chemistry. 868 - 899. 9. 15. 2008. http://dx.doi.org/10.2174/092986708783955428 . 10.2174/092986708783955428 . Current Medicinal Chemistry

3-Oxoandrost-4-en-17ß-yl 1H-imidazole-1-carboxylate

Ramos Silva, Manuela; Matos Beja, Ana; Moreira, Vânia M.; Santos, Rita C.; Salvador, Jorge A. R., Acta Crystallographica Section E Structure Reports Online. o4824 - o4824. 12. 63. 2007. http://dx.doi.org/10.1107/s1600536807057625 . 10.1107/s1600536807057625 . Acta Crystallographica Section E Structure Reports Online

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Vânia M Moreira; Tadas S Vasaitis; Vincent C. O. Njar; Jorge A. R. Salvador, Steroids. 939 - 948. 72. 2007. https://tuhat.helsinki.fi/portal/en/publications/synthesis-and-evaluation-of-novel-17indazole-androstene-derivatives-designed-as-cyp17-inhibitors(54db7897-8f16-4aae-ad4f-0566cefddee7).html . Steroids

Catalytic oxidative processes in steroid chemistry: allylic oxidation, ß-selective epoxidation, alcohol oxidations and remote functionalization reactions

Jorge A. R. Salvador; Samuel M. Silvestre; Vânia M Moreira, Current Organic Chemistry. 2227 - 2257. 10. 2006. https://tuhat.helsinki.fi/portal/en/publications/catalytic-oxidative-processes-in-steroid-chemistry-allylic-oxidation-selective-epoxidation-alcohol-oxidations-and-remote-functionalization-reactions(6fce4065-2a74-4cbe-b81f-3aecf6020eaf).html . Current Organic Chemistry

One-pot, high yield synthesis of a-ketols from delta5-steroids

Jorge A. R. Salvador; Vânia M Moreira; James R. Hanson; Rui A. Carvalho, Steroids. 266 - 272. 71. 2005. https://tuhat.helsinki.fi/portal/en/publications/onepot-high-yield-synthesis-of-ketols-from-delta5steroids(af94a982-b1c0-4b70-acdf-5c87ad6fa556).html . Steroids

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2019/02 - 2021/08

Diterpenoid-based scaffolds for enabling skin repair (DipSkinRepair)

S18-23

Principal investigator

University of Strathclyde

Funders: Tenovus Scotland

2016/09 - 2018/01

Sustainable hydrophobic materials for antimicrobial coatings

1297/31/2016

Principal investigator

Helsingin Yliopisto

Funders: Business Finland

2015/04 - 2016/03

Fully renewable bioactive textiles II

2015 call

Principal investigator

Helsingin Yliopisto

Funders: Huonekalusäätio

2014/04 - 2015/03

Fully renewable bioactive textiles

2014 call

Principal investigator

Helsingin Yliopisto

Funders: Huonekalusäätio

2013/01 - 2015/12

Wood diterpenes as leads to new anti-biofilm strategies (WOODYFILM)

decision 264020

Researcher

Helsingin Yliopisto

Funders: Suomen Akatemia

2013/03 - 2014/02

Synthesis of Oxamniquine Derivatives for Cancer Treatment. A Drug Repositioning Approach

2013 call

Researcher

Helsingin Yliopisto

Funders: Magnus Ehrnroothin Säätiö

2013/11 - 2018/10

Understanding chronic pain and new druggable targets: Focus on glial-opioid receptor interface (GLORIA)

project number 602919

Researcher

Helsingin Yliopisto

Funders: European Commission Seventh Framework Programme for Research and Technological Development

2012/05 - 2013/04

Design, synthesis and biological evaluation of new diterpenoids with potential for the treatment of cancer

ME2012n44

Principal investigator

Helsingin Yliopisto

Funders: Magnus Ehrnroothin Säätiö

2011/09 - 2015/12

Betulins, abietanes and resin acids as novel lead compounds for cancer (BARC)

decision 252308

Researcher

Helsingin Yliopisto

Funders: Suomen Akatemia

2011/06 - 2014/05

FuBio Joint Research 2

Future Biorefinery - FuBio Joint Research 2

Researcher

Helsingin Yliopisto

Funders: Forestcluster Ltd. & TEKES (now Business Finland)

2009/03 - 2012/03

Synthesis and pre-clinical evaluation of novel boron containing compounds as potential antitumor agents

SFRH/BPD/45037/2008

Post-doc Fellow

Universidade de Coimbra

Funders: Associação para a Inovação e Desenvolvimento da FCT

2004/01 - 2008/01

New steroidal inhibitors of androgen biosynthesis

SFRH/BD/12508/2003

PhD Student Fellow

Universidade de Coimbra

Funders: Associação para a Inovação e Desenvolvimento da FCT

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