Neurociências e Doença

Eixo Intestino-Cérebro

Mitocôndria

Microbioma

Imunidade Inata

Doenças Neurodegenerativas

Doenças Neuropsiquiátricas


Linhas de interesse

O eixo intestino-cérebro na etiologia das doenças neurodegenerativas e neuropsiquiátricas

Sinalização da imunidade inata neuronal pela mitocôndria

ASYN como uma proteína bacteriostática.

Visão Geral

Vivemos num mundo onde vários fatores ambientais que favorecem o surgimento de doenças crónicas, como as doenças neurodegenerativas e neuropsiquiátricas, se estão a acumular. Uma área de investigação emergente foca-se no eixo intestino-cérebro (GAin), onde a comunicação bidirecional que liga os sistemas nervoso central e entérico inclui o nervo vago, mas também se estende às vias de comunicação endócrina, humoral, metabólica e imunológica. Investigações recentes indicam que um dos reguladores mais importantes deste eixo é a microbiota intestinal, em particular sua composição e os seus metabolitos. Os principais objetivos do Grupo GAin são: a) validar um novo paradigma para a etiologia das doenças neurodegenerativas e neuropsiquiátricas baseado na interface intestino-cérebro; b) perceber como mitocôndrias disfuncionais levam a respostas imunológicas desreguladas e o seu impacto no sistema nervoso central, tendo em conta a origem microbiana destas e os ecos de eventuais confrontos entre os seus ancestrais evolutivos; c) elucidar a função de proteínas como ASYN que quando agregadas são marcas histopatológicas de doenças neurodegenerativas. Para atingir nossos objetivos, usamos diferentes modelos de ratinho e de células, bem como diferentes técnicas (FACS, IHC, comportamento e outros) para compreender e caracterizar os mecanismos celulares e moleculares na base das alterações cerebrais observadas nos doentes. Pretendemos fornecer bases científicas sólidas para futuros estudos em humanos. O nosso grupo integra investigadores com formações complementares, como neurobiólogos, bioquímicos, farmacêuticos e neurologistas, o que permite ter uma perspectiva mais lata e aprofundada das questões científicas. Estamos comprometidos com a formação de jovens alunos altamente motivados, principalmente ao nível do doutoramento.

Artigos em Destaque

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.

Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.

Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics

The mitochondrial cascade hypothesis for parkinson's disease

Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design


Publicações

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

João Duarte Magalhães; Lígia Fão; Rita Vilaça; Sandra Morais Cardoso; Ana Cristina Rego, 2021. Biomedicines. 2021. https://doi.org/10.3390/biomedicines9111625 . 10.3390/biomedicines9111625 . Biomedicines

Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria

Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2021. Gut. gutjnl - 2021. 2021. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut

The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno, 2021. Antioxidants & Redox Signaling. 694 - 711. 8. 34. 2021. http://dx.doi.org/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.

Cardoso SM, 2021. Biomolecules. 2021. https://europepmc.org/articles/PMC7830597 . 10.3390/biom11010111 . Biomolecules

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Cardoso SM, 2021. Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

The neuromicrobiology of Parkinson’s disease: A unifying theory

Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, 2021. Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al, 2020. Molecules. 4. 25. 2020. http://dx.doi.org/10.3390/molecules25040985 . 10.3390/molecules25040985 . Molecules

Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients

Esteves, A. R.; Cardoso, S. M., 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-70174-z . 10.1038/s41598-020-70174-z . Scientific Reports

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2020. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry

Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration

Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno, 2020. Frontiers in Aging Neuroscience. 12. 2020. http://dx.doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . Frontiers in Aging Neuroscience

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos, 2019. Molecules. 2019. http://www.mdpi.com/1420-3049/24/3/587 . 10.3390/molecules24030587 . Molecules

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso, 2019. Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. https://doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2018. European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry

Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols

Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R., 2018. Neurotoxicity Research. 410 - 420. 2. 35. 2018. http://dx.doi.org/10.1007/s12640-018-9966-3 . 10.1007/s12640-018-9966-3 . Neurotoxicity Research

Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.

2018. Molecular neurobiology. 2018. http://europepmc.org/abstract/med/28168426 . 10.1007/s12035-017-0420-y . Molecular neurobiology

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.

Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA, 2018. Journal of inorganic biochemistry. 2018. http://europepmc.org/abstract/med/29182921 . 10.1016/j.jinorgbio.2017.11.015 . Journal of inorganic biochemistry

The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease

Cardoso, Sandra M.; Empadinhas, Nuno, 2018. Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry

Effects of mild running on substantia nigra during early neurodegeneration.

Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al, 2017. Journal of sports sciences. 2017. http://europepmc.org/abstract/med/28895489 . 10.1080/02640414.2017.1378494 . Journal of sports sciences

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.

Cardoso SM, 2017. 2017. http://europepmc.org/abstract/med/27311773 .

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.

Esteves AR; Cardoso SM, 2016. 2016. http://europepmc.org/abstract/med/26740081 .

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al, 2016. 2016. http://europepmc.org/abstract/med/26799652 . 10.1080/15548627.2015.1100356 .

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.

Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA, 2016. 2016. http://europepmc.org/abstract/med/26256122 . 10.1111/cbdd.12633 .

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates

Sandra Morais Cardoso, 2016. RSC Advances . 2016. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation . published RSC Advances

Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates

Sandra Morais Cardoso, 2015. Medicinal Chemical Communications. 2015. https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract . published Medicinal Chemical Communications

The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer’s disease

Fonseca, Ana Catarina R.G.; Resende, Rosa; Cardoso, Sandra M.; Pereira, Cláudia F., 2015. Endoplasmic Reticulum Stress in Diseases. 1. 2. 2015. http://dx.doi.org/10.1515/ersc-2015-0005 . 10.1515/ersc-2015-0005 . Endoplasmic Reticulum Stress in Diseases

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.

Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .

Special focus on autophagy.

Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25844484 . 10.1089/dna.2015.1501 .

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.

Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .

Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum

Sandra Morais Cardoso; Fonseca AC, 2015. Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.428 . 10.14800/ttnd.428 . Therapeutic Targets for Neurological Diseases

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS . 10.1016/j.bbamcr.2014.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M., 2014. Experimental Neurology. 206 - 216. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology

Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2013. Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al, 2013. Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS . 10.1093/hmg/ddt247 . Human Molecular Genetics

Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease

Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2013. Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease

Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., 2013. Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry

Multifunctional iron-chelators with protective roles against neurodegenerative diseases

Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A., 2013. Dalton Transactions. 6058 - 6073. 17. 42. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS . 10.1039/c3dt50406a . Dalton Transactions

Mitochondrial dynamics and neuronal fate in Parkinson's disease

Santos, D.; Cardoso, S.M., 2012. Mitochondrion. 428 - 437. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS . 10.1016/j.mito.2012.05.002 . Mitochondrion

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a

Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease

Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease

Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., 2012. Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases

Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?

Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., 2012. Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, 2012. Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, 2011. Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell

The mitochondrial cascade hypothesis for parkinson's disease

Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design

Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases

Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., 2011. Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A., 2011. Journal of Enzyme Inhibition and Medicinal Chemistry. 485 - 497. 4. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS . 10.3109/14756366.2010.529806 . Journal of Enzyme Inhibition and Medicinal Chemistry

Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease

Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2011. Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research

Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease

Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway

Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2011. Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease

Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD

Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2010. Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease

Polymorphic variation in cytochrome oxidase subunit genes

Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, 2010. Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease

Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis

Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R., 2010. Frontiers in Aging Neuroscience. MAY. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience

Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2010. CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, 2010. Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology

Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer

Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, 2010. Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Microtubule depolymerization potentiates alpha-synuclein oligomerization

Esteves, A. Raquel, 2010. Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2009. Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., 2009. Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International

Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background

Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Mitochondrion. 219 - 228. 3. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS . 10.1016/j.mito.2008.03.004 . Mitochondrion

New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs

Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A., 2008. Frontiers in Bioscience. 6763 - 6774. 17. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS . Frontiers in Bioscience

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells

Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research

Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine

The key role of mitochondria in Alzheimer's disease

Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research

The role of calcineurin in amyloid-ß-peptides-mediated cell death

Cardoso, S.M.; Oliveira, C.R., 2005. Brain Research. 1 - 7. 1-2. 1050. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS . 10.1016/j.brainres.2005.04.078 . Brain Research

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies

Pereira, C.; Agostinho, P.; Moreira, P.; Cardoso, S.; Oliveira, C., 2005. Current Drug Target -CNS & Neurological Disorders. 383 - 403. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546117 . 10.2174/1568007054546117 . Current Drug Target -CNS & Neurological Disorders

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease

Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende, 2004. Journal of Molecular Neuroscience. 097 - 104. 1-2. 23. 2004. http://dx.doi.org/10.1385/jmn:23:1-2:097 . 10.1385/jmn:23:1-2:097 . Journal of Molecular Neuroscience

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., 2004. Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . Journal of Molecular Neuroscience

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R., 2004. Neurobiology of Aging. 105 - 110. 1. 25. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS . 10.1016/S0197-4580(03)00033-2 . Neurobiology of Aging

Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells

Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., 2004. Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity

Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R., 2004. Journal of Neurochemistry. 1417 - 1426. 6. 89. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02438.x . Journal of Neurochemistry

Glutathione cycle impairment mediates Aß-induced cell toxicity

Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 241 - 250. 3. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS . 10.1080/1071576021000041023 . Free Radical Research

Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides

Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 967 - 973. 9. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS . 10.1080/10715760310001595757 . Free Radical Research

Induction of cytocrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria

Sandra M Cardoso, 2002. Brain Research. 2002. Brain Research

Functional mitochondria are required for amyloid beta-mediated neurotoxicity.

Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Contribuição para o estudo do metabolismo da amiodarona: variação da concentração do iodo em diferentes orgãos dos ratinhos, após administração intraperitonial do fármaco.

Cardoso SM, 1994. Coimbra Médica. 15. 1994. Coimbra Médica

Prémios

2016

Prémio Santa Casa Neurociências Mantero Belard, Santa Casa da Misericórdia de Lisboa

2014

Prémio Janssen Neuroscience, Janssen Pharmaceutics

2013

Distinção com Medalha de Prata de reconhecimento em Investigação Científica pelo Ministro da Saúde português

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