Mitochondria
Microbiome
Innate Immunity
Neurodegenerative Disorders
Neuropsychiatric Disorders
The Gut-Brain axis in the etiology of neurodegenerative and neuropsychiatric diseases
Mitochondrial signaling of neuronal innate immunity
ASYN as a bacteriostatic protein.
We live in a world where several environmental factors that favor the development of chronic neurodegenerative and neuropsychiatric disorders are accruing. A cutting-edge area of research involves the gut-brain axis (GAin), in which the bidirectional communication between the enteric and central nervous systems via the vagus nerve also extends to endocrine, humoral, metabolic and immune pathways. Recent research indicates that a key regulator of this axis is the gut microbiota, in particular its composition and metabolites. The main objectives of the GAin group are: a) to validate a new paradigm for the etiology of neurodegenerative and neuropsychiatric diseases at the interface gut-brain; b) to study how dysfunctional mitochondria leads to deregulated immune responses and what is the impact on the central nervous system, taking into account their microbial origin and the echoes of eventual confrontations between their evolutionary ancestors; c) to elucidate the role of proteins such as ASYN that are hallmarks of neurodegenerative disorders. To achieve our goals, models such as cell lines and mice, as well as different techniques (FACS, IHC, behavior and others) are used to understand and characterize the cellular and molecular mechanisms that underlie brain changes and to provide scientific bases for future studies in humans. Our group integrates researchers with complementary backgrounds, such as neurobiologists, biochemists, pharmacists and neurologists, allowing a more in-depth integrated perspective of the scientific questions. We are also committed to the education of young highly motivated students, mostly at the PhD level.
Information about journal articles, updated at 26-03-2023, from platform CIÊNCIAVITAE.
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2023. Gut. 73 - 89. 1. 72. 2023. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut
The neuromicrobiology of Parkinson’s disease: A unifying theory
Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, 2021. Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation
The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease
Cardoso, Sandra M.; Empadinhas, Nuno, 2018. Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .
The mitochondrial cascade hypothesis for parkinson's disease
Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics
Functional mitochondria are required for amyloid beta-mediated neurotoxicity.
Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
5 10 out of 10 Featured Publications
Information about journal articles, updated at 26-03-2023, from platform CIÊNCIAVITAE.
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2023. Gut. 73 - 89. 1. 72. 2023. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut
The role of bacteria-mitochondria communication in the activation of neuronal innate immunity: implications to Parkinson’s disease
João Duarte Magalhães, 2023. International Journal of Molecular Sciences. 2023. accepted International Journal of Molecular Sciences
Mitochondrial signaling on innate immunity activation in Parkinson disease
João D. Magalhães; Sandra Morais Cardoso, 2023. Current Opinion in Neurobiology. 2023. https://doi.org/10.1016/j.conb.2022.102664 . 10.1016/j.conb.2022.102664 . Current Opinion in Neurobiology
Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease
David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al, 2022. Biomedicines. 2022. https://doi.org/10.3390/biomedicines10071510 . 10.3390/biomedicines10071510 . Biomedicines
Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel, 2022. Antioxidants. 11. 11. 2022. http://dx.doi.org/10.3390/antiox11112141 . 10.3390/antiox11112141 . published Antioxidants
Parkinson's Disease: A Multisystem Disorder
Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, 2022. Neuroscience Bulletin. 113 - 124. 1. 39. 2022. http://dx.doi.org/10.1007/s12264-022-00934-6 . 10.1007/s12264-022-00934-6 . published Neuroscience Bulletin
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.
Cardoso SM, 2021. Biomolecules. 2021. https://europepmc.org/articles/PMC7830597 . 10.3390/biom11010111 . Biomolecules
The neuromicrobiology of Parkinson’s disease: A unifying theory
Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, 2021. Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews
The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease
Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno, 2021. Antioxidants & Redox Signaling. 694 - 711. 8. 34. 2021. http://dx.doi.org/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling
Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
João Duarte Magalhães; Lígia Fão; Rita Vilaça; Sandra Morais Cardoso; Ana Cristina Rego, 2021. Biomedicines. 2021. https://doi.org/10.3390/biomedicines9111625 . 10.3390/biomedicines9111625 . Biomedicines
Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease
Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Cardoso SM, 2021. Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al, 2020. Molecules. 4. 25. 2020. http://dx.doi.org/10.3390/molecules25040985 . 10.3390/molecules25040985 . Molecules
Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease
Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2020. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry
Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
Esteves, A. R.; Cardoso, S. M., 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-70174-z . 10.1038/s41598-020-70174-z . Scientific Reports
Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization
Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry
Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration
Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno, 2020. Frontiers in Aging Neuroscience. 12. 2020. http://dx.doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . Frontiers in Aging Neuroscience
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology
Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Is Alzheimer’s disease an inflammasomopathy?
Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos, 2019. Molecules. 2019. http://www.mdpi.com/1420-3049/24/3/587 . 10.3390/molecules24030587 . Molecules
The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease
A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso, 2019. Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. https://doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease
Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2018. European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry
The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease
Cardoso, Sandra M.; Empadinhas, Nuno, 2018. Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology
Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug
Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry
Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.
Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA, 2018. Journal of inorganic biochemistry. 2018. http://europepmc.org/abstract/med/29182921 . 10.1016/j.jinorgbio.2017.11.015 . Journal of inorganic biochemistry
Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols
Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R., 2018. Neurotoxicity Research. 410 - 420. 2. 35. 2018. http://dx.doi.org/10.1007/s12640-018-9966-3 . 10.1007/s12640-018-9966-3 . Neurotoxicity Research
Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.
2018. Molecular neurobiology. 2018. http://europepmc.org/abstract/med/28168426 . 10.1007/s12035-017-0420-y . Molecular neurobiology
Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.
Cardoso SM, 2017. 2017. http://europepmc.org/abstract/med/27311773 .
Effects of mild running on substantia nigra during early neurodegeneration.
Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al, 2017. Journal of sports sciences. 2017. http://europepmc.org/abstract/med/28895489 . 10.1080/02640414.2017.1378494 . Journal of sports sciences
LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.
Esteves AR; Cardoso SM, 2016. 2016. http://europepmc.org/abstract/med/26740081 .
Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates
Sandra Morais Cardoso, 2016. RSC Advances . 2016. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation . published RSC Advances
New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.
Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA, 2016. 2016. http://europepmc.org/abstract/med/26256122 . 10.1111/cbdd.12633 .
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al, 2016. 2016. http://europepmc.org/abstract/med/26799652 . 10.1080/15548627.2015.1100356 .
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .
Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates
Sandra Morais Cardoso, 2015. Medicinal Chemical Communications. 2015. https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract . published Medicinal Chemical Communications
Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum
Sandra Morais Cardoso; Fonseca AC, 2015. Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.428 . 10.14800/ttnd.428 . Therapeutic Targets for Neurological Diseases
The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer’s disease
Fonseca, Ana Catarina R.G.; Resende, Rosa; Cardoso, Sandra M.; Pereira, Cláudia F., 2015. Endoplasmic Reticulum Stress in Diseases. 1. 2. 2015. http://dx.doi.org/10.1515/ersc-2015-0005 . 10.1515/ersc-2015-0005 . Endoplasmic Reticulum Stress in Diseases
Special focus on autophagy.
Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25844484 . 10.1089/dna.2015.1501 .
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M., 2014. Experimental Neurology. 206 - 216. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology
Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells
Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS . 10.1016/j.bbamcr.2014.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease
Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., 2013. Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry
Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2013. Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy
Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines
Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al, 2013. Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS . 10.1093/hmg/ddt247 . Human Molecular Genetics
Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease
Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2013. Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research
Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells
Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Multifunctional iron-chelators with protective roles against neurodegenerative diseases
Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A., 2013. Dalton Transactions. 6058 - 6073. 17. 42. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS . 10.1039/c3dt50406a . Dalton Transactions
Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions
Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging
Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a
Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, 2012. Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy
Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?
Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., 2012. Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology
Mitochondrial dynamics and neuronal fate in Parkinson's disease
Santos, D.; Cardoso, S.M., 2012. Mitochondrion. 428 - 437. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS . 10.1016/j.mito.2012.05.002 . Mitochondrion
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics
Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease
Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., 2012. Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases
The mitochondrial cascade hypothesis for parkinson's disease
Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design
Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases
Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., 2011. Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design
Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD
Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization
Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, 2011. Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell
Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway
Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2011. Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease
Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease
Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2011. Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research
Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors
Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A., 2011. Journal of Enzyme Inhibition and Medicinal Chemistry. 485 - 497. 4. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS . 10.3109/14756366.2010.529806 . Journal of Enzyme Inhibition and Medicinal Chemistry
Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease
Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology
Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2010. CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets
Mitochondrial-dependent apoptosis in Huntington's disease human cybrids
Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, 2010. Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology
Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2010. Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis
Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R., 2010. Frontiers in Aging Neuroscience. MAY. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience
Polymorphic variation in cytochrome oxidase subunit genes
Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, 2010. Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease
Microtubule depolymerization potentiates alpha-synuclein oligomerization
Esteves, A. Raquel, 2010. Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience
ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria
Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer
Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, 2010. Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry
Mitochondria as a therapeutic target in Alzheimer's disease and diabetes
Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells
Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports
Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2009. Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., 2009. Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International
Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126
Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry
Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells
Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research
New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs
Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A., 2008. Frontiers in Bioscience. 6763 - 6774. 17. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS . Frontiers in Bioscience
Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease
Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background
Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Mitochondrion. 219 - 228. 3. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS . 10.1016/j.mito.2008.03.004 . Mitochondrion
The key role of mitochondria in Alzheimer's disease
Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies
Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders
The role of calcineurin in amyloid-ß-peptides-mediated cell death
Cardoso, S.M.; Oliveira, C.R., 2005. Brain Research. 1 - 7. 1-2. 1050. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS . 10.1016/j.brainres.2005.04.078 . Brain Research
Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies
Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders
Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity
Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research
Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
Pereira, C.; Agostinho, P.; Moreira, P.; Cardoso, S.; Oliveira, C., 2005. Current Drug Target -CNS & Neurological Disorders. 383 - 403. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546117 . 10.2174/1568007054546117 . Current Drug Target -CNS & Neurological Disorders
Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease
Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende, 2004. Journal of Molecular Neuroscience. 097 - 104. 1-2. 23. 2004. http://dx.doi.org/10.1385/jmn:23:1-2:097 . 10.1385/jmn:23:1-2:097 . Journal of Molecular Neuroscience
Cytochrome c oxidase is decreased in Alzheimer's disease platelets
Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R., 2004. Neurobiology of Aging. 105 - 110. 1. 25. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS . 10.1016/S0197-4580(03)00033-2 . Neurobiology of Aging
Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease
Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., 2004. Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . Journal of Molecular Neuroscience
Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells
Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., 2004. Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity
Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R., 2004. Journal of Neurochemistry. 1417 - 1426. 6. 89. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02438.x . Journal of Neurochemistry
Glutathione cycle impairment mediates Aß-induced cell toxicity
Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 241 - 250. 3. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS . 10.1080/1071576021000041023 . Free Radical Research
Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides
Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 967 - 973. 9. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS . 10.1080/10715760310001595757 . Free Radical Research
Induction of cytocrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria
Sandra M Cardoso, 2002. Brain Research. 2002. Brain Research
Functional mitochondria are required for amyloid beta-mediated neurotoxicity.
Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitochondrial function is differentially affected upon oxidative stress
Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine
The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes
Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications
Contribuição para o estudo do metabolismo da amiodarona: variação da concentração do iodo em diferentes orgãos dos ratinhos, após administração intraperitonial do fármaco.
Cardoso SM, 1994. Coimbra Médica. 15. 1994. Coimbra Médica
5 104 out of 104 Publications
Distinguished with the Prémio Santa Casa Neurociências Mantero Belard, from Santa Casa da Misericórdia de Lisboa
Distinguished with the Janssen Neuroscience Award, from Janssen Pharmaceutics
2013, Distinguished with the Silver Medal for Scientific Research Achievements, from the Portuguese Ministry of Health
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