Emanuel Monteiro Candeias

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway

Diniz, Antónia; Alves, Marco G.; Candeias, Emanuel; Duarte, Ana I.; Moreira, Paula I.; Silva, Branca M.; Oliveira, Pedro F.; Rato, Luís, International Journal of Molecular Sciences. 16. 23. 2022. http://dx.doi.org/10.3390/ijms23168912 . 10.3390/ijms23168912 . International Journal of Molecular Sciences

Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria

Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, Gut. gutjnl - 2021. 2021. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . Gut

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . Journal of Neuroinflammation

Liraglutide Protects Against Brain Amyloid-ß1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

Candeias, Emanuel, International Journal of Molecular Sciences. 2020. http://dx.doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences

Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging

Candeias, Emanuel, Neurobiology of Aging. 2020. http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.004 . 10.1016/j.neurobiolaging.2020.01.004 . Neurobiology of Aging

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Candeias, Emanuel, Molecules. 2019. http://dx.doi.org/10.3390/molecules24030587 . 10.3390/molecules24030587 . Molecules

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, Emanuel, Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, Emanuel, Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-016-0155-1 . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide

Candeias, Emanuel, World Journal of Diabetes. 2015. http://dx.doi.org/10.4239/wjd.v6.i6.807 . 10.4239/wjd.v6.i6.807 . World Journal of Diabetes

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

Candeias, Emanuel, Journal of Bioenergetics and Biomembranes. 2015. http://dx.doi.org/10.1007/s10863-014-9580-x . 10.1007/s10863-014-9580-x . Journal of Bioenergetics and Biomembranes

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

Candeias, Emanuel, CNS & Neurological Disorders - Drug Targets. 2015. http://dx.doi.org/10.2174/1871527314666150429112353 . 10.2174/1871527314666150429112353 . CNS & Neurological Disorders - Drug Targets

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

Candeias, Emanuel, Expert Review of Neurotherapeutics. 2015. http://dx.doi.org/10.1586/14737175.2015.1058160 . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia

Candeias, Emanuel, Frontiers in Endocrinology. 2014. http://dx.doi.org/10.3389/fendo.2014.00110 . 10.3389/fendo.2014.00110 . Frontiers in Endocrinology

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Candeias, Emanuel, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2014. http://dx.doi.org/10.1016/j.bbadis.2014.05.003 . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins

Candeias, Emanuel, Current Molecular Medicine. 2013. http://dx.doi.org/10.2174/1566524011313040010 . 10.2174/1566524011313040010 . Current Molecular Medicine

Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!

Candeias, Emanuel, Current Pharmaceutical Design. 2013. http://dx.doi.org/10.2174/1381612811319380013 . 10.2174/1381612811319380013 . Current Pharmaceutical Design

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Candeias, Emanuel, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. http://dx.doi.org/10.1016/j.bbadis.2013.01.008 . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Alzheimer disease as a vascular disorder: Where do mitochondria fit?

Candeias, Emanuel, Experimental Gerontology. 2012. http://dx.doi.org/10.1016/j.exger.2012.07.006 . 10.1016/j.exger.2012.07.006 . Experimental Gerontology

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

Candeias, Emanuel, Brain Research. 2012. http://dx.doi.org/10.1016/j.brainres.2011.12.063 . 10.1016/j.brainres.2011.12.063 . Brain Research

The impairment of insulin signaling in Alzheimer's disease

Candeias, Emanuel, IUBMB Life. 2012. http://dx.doi.org/10.1002/iub.1098 . 10.1002/iub.1098 . IUBMB Life