Espectro do autismo
Neurodesenvolvimento
Modelos de doença
Comportamento
Eletrofisiologia
Plasticidade sináptica e autismo
Synaptic plasticity and autism
Stress precoce e concepções cerebrais
ProTeAN: Organoides cerebrais
Microglia e Neurodesenvolvimento
O cérebro evoluiu para proporcionar capacidades sensoriais, emocionais, de memória e cognitivas espantosas. De uma perspetiva evolutiva, tem-se argumentado que as alterações mais críticas impostas ao cérebro dos mamíferos estão diretamente relacionadas com o aperfeiçoamento do “cérebro social”. Os mamíferos utilizam várias regiões cerebrais para processar e responder plenamente aos ambientes sociais - desde os sentidos, à memória dos outros e aos centros emocionais. Como consequência desta complexidade, as perturbações neuropsiquiátricas e do neurodesenvolvimento partilham deficiências nos comportamentos sociais. A nossa investigação visa compreender, a nível molecular, celular e dos circuitos, como a genética, o ambiente e as interacções gene-ambiente influenciam a função dos circuitos neuronais na saúde e na doença, com um enfoque específico nas perturbações do neurodesenvolvimento e nos comportamentos sociais. Para atingir este objetivo, utilizamos uma combinação de técnicas de genética molecular, comportamento, eletrofisiologia e optogenética. Especificamente, desenvolvemos modelos de doença baseados em células humanas e de ratinhos para compreender os componentes genéticos e ambientais das doenças do desenvolvimento neurológico, com especial incidência nos mecanismos subjacentes aos comportamentos que fazem lembrar estas condições.
Informação sobre artigos em revista, actualizada a 04-05-2025, a partir da plataforma CIÊNCIAVITAE.
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al, 2019. Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications
Distinct subnetworks of the thalamic reticular nucleus
Li, Yinqing; Lopez-Huerta, Violeta G.; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K.; Arias-Garcia, Mario A.; et al, 2020. Nature. 819 - 824. 7818. 583. 2020. http://dx.doi.org/10.1038/s41586-020-2504-5 . 10.1038/s41586-020-2504-5 . Nature
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J.; Feliciano, C.; Ting, J.T.; Wang, W.; Wells, M.F.; Venkatraman, T.N.; Lascola, C.D.; Fu, Z.; Feng, G., 2011. Nature. 437 - 442. 7344. 472. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955536349&partnerID=MN8TOARS . 10.1038/nature09965 . Nature
miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al, 2020. Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al, 2023. Neuron. 3435 - 3449.e8. 21. 111. 2023. http://dx.doi.org/10.1016/j.neuron.2023.09.031 . 10.1016/j.neuron.2023.09.031 . Neuron
Informação sobre artigos em revista, actualizada a 04-05-2025, a partir da plataforma CIÊNCIAVITAE.
Early-life IL-4 administration induces long-term changes in microglia in the cerebellum and prefrontal cortex
Pedro A. Ferreira; Carolina Lebre; Jéssica Costa; Francisca Amaral; Rosário Ferreira; Filipe Martinho; Vítor H. Paiva; et al, 2025. Journal of Neurochemistry. 2025. https://doi.org/10.1111/jnc.16266 . 10.1111/jnc.16266 . Journal of Neurochemistry
MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
Rodrigues, Beatriz; Leitão, Ricardo A.; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela S.; Abreu, Mónica; et al, 2024. Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02715-1 . 10.1038/s41380-024-02715-1 . Molecular Psychiatry
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny
Pereira, Marta I.; Laranjo, Mariana; Gomes, Marcos; Edfawy, Mohamed; Peça, João, 2024. Scientific Reports. 1. 14. 2024. http://dx.doi.org/10.1038/s41598-024-62088-x . 10.1038/s41598-024-62088-x . Scientific Reports
Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing
Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; et al, 2024. Angewandte Chemie International Edition. 2024. http://dx.doi.org/10.1002/anie.202401004 . 10.1002/anie.202401004 . Angewandte Chemie International Edition
Engineering optical tools for remotely controlled brain stimulation and regeneration
Rodrigues, Artur Filipe; Rebelo, Catarina; Reis, Tiago; Simões, Susana; Bernardino, Liliana; Peça, João; Ferreira, Lino, 2023. Biomaterials Science. 2023. http://dx.doi.org/10.1039/d2bm02059a . 10.1039/d2bm02059a . Biomaterials Science
A Novel Genetic Variant in <i>MBD5</i> Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia
Mariana Martins; Ana Rafaela Oliveira; Solange Martins; José Vieira; Pedro Perdigão; Ana Rita Fernandes; Pereira de Almeida L; et al, 2023. International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/16/12603 . 10.3390/ijms241612603 . International Journal of Molecular Sciences
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al, 2023. Neuron. 3435 - 3449.e8. 21. 111. 2023. http://dx.doi.org/10.1016/j.neuron.2023.09.031 . 10.1016/j.neuron.2023.09.031 . Neuron
In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions
Ferreira-Fernandes, Emanuel; Laranjo, Mariana; Reis, Tiago; Canijo, Bárbara; Ferreira, Pedro A.; Martins, Pedro; Vilarinho, João; et al, 2023. Frontiers in Neural Circuits. 17. 2023. http://dx.doi.org/10.3389/fncir.2023.1293620 . 10.3389/fncir.2023.1293620 . Frontiers in Neural Circuits
Brain Gain - Discovering Neurosciences: A digital education outreach project for higher education students
Laranjo, Mariana; Amaral, Sara; Caetano, Carolina; Santos, Sílvio; Campos, Rita; Peça, João; Seabra, Catarina M., 2023. The Biochemist. 21 - 27. 2. 45. 2023. http://dx.doi.org/10.1042/bio_2023_104 . 10.1042/bio_2023_104 . The Biochemist
Scaffolds for Dentin-Pulp Complex Regeneration
Sequeira, Diana B.; Diogo, Patrícia; Gomes, Brenda P. F. A.; Peça, João; Santos, João Miguel Marques, 2023. Medicina. 1. 60. 2023. http://dx.doi.org/10.3390/medicina60010007 . 10.3390/medicina60010007 . Medicina
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability
Caldeira, Gladys Lima; Inácio, Ângela; Beltrão, Nuno; Barreto, Carlos A. V.; Ventura Rodrigues, Marina; Rondão, Tiago; Macedo, Renato; et al, 2022. Molecular Psychiatry. 2022. https://www.nature.com/articles/s41380-022-01487-w . published Molecular Psychiatry
The Neural Circuit Architecture of Social Hierarchy in Rodents and Primates
Ferreira-Fernandes, Emanuel; Peça, João, 2022. Frontiers in Cellular Neuroscience. 16. 2022. http://dx.doi.org/10.3389/fncel.2022.874310 . 10.3389/fncel.2022.874310 . Frontiers in Cellular Neuroscience
Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model
Serra, Diana; Henriques, Joana F.; Sousa, Fábio J.; Laranjo, Mariana; Resende, Rosa; Ferreira-Marques, Marisa; de Freitas, Victor; et al, 2022. International Journal of Molecular Sciences. 16. 23. 2022. http://dx.doi.org/10.3390/ijms23169259 . 10.3390/ijms23169259 . International Journal of Molecular Sciences
Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations
Ana Rafaela Oliveira; Solange Martins; Giuseppe Cammarata; Mariana Martins; Ana Maria Cardoso; Maria Rosário Almeida; Maria do Carmo Macário; et al, 2022. Biomedicines. 2022. https://doi.org/10.3390/biomedicines10081905 . 10.3390/biomedicines10081905 . Biomedicines
Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications
Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; et al, 2022. Nature Communications. 1. 13. 2022. http://dx.doi.org/10.1038/s41467-022-31791-6 . 10.1038/s41467-022-31791-6 . Nature Communications
Microglia-dependent remodeling of neuronal circuits
Joana R. Guedes; Pedro A. Ferreira; Jéssica M. Costa; Ana L. Cardoso; João Peça, 2022. Journal of Neurochemistry. 2022. https://doi.org/10.1111/jnc.15689 . 10.1111/jnc.15689 . Journal of Neurochemistry
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation
Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, 2021. Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . Science Signaling
Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials
Sequeira, Diana B.; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo J.; Ramos, Carlos; Figueiredo, Maria H.; Santos, Ana C.; et al, 2021. Clinical Oral Investigations. 2021. http://dx.doi.org/10.1007/s00784-021-03840-9 . 10.1007/s00784-021-03840-9 . Clinical Oral Investigations
The old guard: Age-related changes in microglia and their consequences
Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso, 2021. Mechanisms of Ageing and Development. 111512 - 111512. 197. 2021. https://doi.org/10.1016/j.mad.2021.111512 . 10.1016/j.mad.2021.111512 . Mechanisms of Ageing and Development
The postsynaptic scaffolding protein SAPAP3 controls mitochondrial dynamics and function
Coelho, Patrícia; Lourenço, Ana Sofia; Ferreira, Íldete Luísa; Marinho, Daniela; Anjo, Sandra Isabel; Mas, Philippe J.; Carvalho, MJ; et al, 2021. Nature Communications. 2021. submitted Nature Communications
Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling
Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al, 2020. Neuropsychopharmacology. 1438 - 1447. 9. 45. 2020. http://dx.doi.org/10.1038/s41386-020-0727-7 . 10.1038/s41386-020-0727-7 . Neuropsychopharmacology
Distinct subnetworks of the thalamic reticular nucleus
Li, Yinqing; Lopez-Huerta, Violeta G.; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K.; Arias-Garcia, Mario A.; et al, 2020. Nature. 819 - 824. 7818. 583. 2020. http://dx.doi.org/10.1038/s41586-020-2504-5 . 10.1038/s41586-020-2504-5 . Nature
miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al, 2020. Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids
New insights on synaptic dysfunction in neuropsychiatric disorders
Lima Caldeira, Gladys; Peça, João; Carvalho, Ana Luísa, 2019. Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://dx.doi.org/10.1016/j.conb.2019.01.004 . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al, 2019. Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications
Effects of a New Bioceramic Material on Human Apical Papilla Cells
Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João, 2018. Journal of Functional Biomaterials. 4. 9. 2018. http://dx.doi.org/10.3390/jfb9040074 . 10.3390/jfb9040074 . Journal of Functional Biomaterials
Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles
Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; et al, 2017. Acta Biomaterialia. 293 - 302. 59. 2017. http://dx.doi.org/10.1016/j.actbio.2017.06.044 . 10.1016/j.actbio.2017.06.044 . published Acta Biomaterialia
Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders
Ting, Jonathan T.*; Peça, João*; Feng, Guoping, 2012. Annual Review of Neuroscience. 49 - 71. 1. 35. 2012. http://dx.doi.org/10.1146/annurev-neuro-062111-150442 . 10.1146/annurev-neuro-062111-150442 . Annual Review of Neuroscience
Cellular and synaptic network defects in autism
Peça, J.; Feng, G., 2012. Current Opinion in Neurobiology. 866 - 872. 5. 22. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867426528&partnerID=MN8TOARS . 10.1016/j.conb.2012.02.015 . Current Opinion in Neurobiology
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J.; Feliciano, C.; Ting, J.T.; Wang, W.; Wells, M.F.; Venkatraman, T.N.; Lascola, C.D.; Fu, Z.; Feng, G., 2011. Nature. 437 - 442. 7344. 472. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955536349&partnerID=MN8TOARS . 10.1038/nature09965 . Nature
Neuroscience: When lights take the circuits out
Peça, J.; Feng, G., 2011. Nature. 165 - 166. 7363. 477. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052602669&partnerID=MN8TOARS . 10.1038/477165a . Nature
SnapShot: Autism and the synapse
Peça, J.; Ting, J.; Feng, G., 2011. Cell. 3. 147. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855174133&partnerID=MN8TOARS . 10.1016/j.cell.2011.10.015 . Cell
Using Light to Reinstate Respiratory Plasticity
Arenkiel, Benjamin R.; Peça, João, 2009. Journal of Neurophysiology. 1695 - 1698. 4. 101. 2009. http://dx.doi.org/10.1152/jn.00009.2009 . 10.1152/jn.00009.2009 . Journal of Neurophysiology
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Welch, Jeffrey M.; Lu, Jing; Rodriguiz, Ramona M.; Trotta, Nicholas C.; Peca, Joao; Ding, Jin-Dong; Feliciano, Catia; et al, 2007. Nature. 894 - 900. 7156. 448. 2007. http://dx.doi.org/10.1038/nature06104 . 10.1038/nature06104 . Nature
In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2
Arenkiel, Benjamin R.; Peca, Joao; Davison, Ian G.; Feliciano, Catia; Deisseroth, Karl; Augustine, George J.; Ehlers, Michael D.; Feng, Guoping, 2007. Neuron. 205 - 218. 2. 54. 2007. http://dx.doi.org/10.1016/j.neuron.2007.03.005 . 10.1016/j.neuron.2007.03.005 . published Neuron
High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice
Wang, H.*; Peca, J.*; Matsuzaki, M.*; Matsuzaki, K.; Noguchi, J.; Qiu, L.; Wang, D.; et al, 2007. Proceedings of the National Academy of Sciences. 8143 - 8148. 19. 104. 2007. http://dx.doi.org/10.1073/pnas.0700384104 . 10.1073/pnas.0700384104 . Proceedings of the National Academy of Sciences
5 36 de 36 Publicações
Reorganização pós-natal do cerebelo via interação neurónio-microglia: o papel da IL-4 como um mediador entre PHDA e alergias
2021-02-01
ELEANA: Alergénios ambientais no início de vida e a PHDA
2024-04-09
Syn2Psy - Disfunção Sináptica nos Transtornos Neuropsiquiátricos
2019-03-01
Conseguirá a microglia saudável impedir a neuroinflamação e a disfunção sináptica em organoides cerebrais humanos com mutações associadas a DFTL?
2021-03-31
ProTeAN - Produção e teste de neurónios humanos e organoides cerebrais
2018-05-07
Pfizer Prize - Basic Science
Special Recognition - Science World Cultural Council
IBRO Early Career Award
NARSAD Young Investigator Award
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