Ana Luísa Colaço Cardoso

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Investigador(a)

Circuitos Neuronais e Comportamento

E-mail
anacardoso@cnc.uc.pt
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Visão Geral

Ana Luísa Cardoso graduated in Biochemistry from the University of Coimbra (UC) in 2004, being awarded a merit prize as one of the 3% top students of the Faculty for Science and Technology of UC. In the same year she received a Ph.D scholarship from the Portuguese Science Foundation (FCT) and initiated her Ph.D under the supervision of Prof. Dr. Conceição Pedroso de Lima at the Biochemistry Department of UC. Between 2004 and 2008 she worked in the development of lipid-based nanoparticles for siRNA delivery to the CNS, aiming at generating new therapeutic tools for treatment of acute brain lesion. Her Ph. D. project was performed in collaboration with Prof. Ernst Wagner and Dr. Carsten Culmsee, at the Faculty of Pharmacy of Ludwig-Maximillian University (LMU) and with Prof. Dr. Nikolaus PLesnila, at the Institute for Stroke and Dementia Research (LMU) in Munich, where she had the opportunity to develop research work during 2006 and 2007. After obtaining her Ph.D. in Biochemical Technology (2008), Ana Cardoso integrated the Center for Neuroscience and Cell Biology (CNC) as a Post Doc, where she had the opportunity to study the role of miRNA deregulation in CNS diseases, including glioblastoma and Alzheimer’s disease (AD). In 2012, Ana Cardoso was awarded a grant from FCT to develop a new lentiviral-based platform to modulate miRNAs in AD animal models, aiming at decreasing APP and BACE levels and improving neuronal deficits. As a result of her efforts, in 2013, she was selected to integrate the project “New strategies to manage brain diseases”, assuming a two-year position as Invited Auxiliary Investigator at UC. From 2013 to 2015 Ana Cardoso gave her first steps as an independent scientist, focusing her research in the field of neuroimmunology, and publishing her first papers as corresponding author. In 2016 she was awarded a second Pos Doc fellowship to continue to investigate the contribution of miRNAs to the modulation of innate immune responses. During her career,Ana Cardoso has worked in close proximity with several national and international Ph.D and Master Programs, successfully supervising 9 Master students and 2 Ph.D student and organizing/participating in several Advanced Courses in Neurosciences, Gene Therapy and Epigenetics, both at CNC and in other Portuguese Institutions. In 2017, Ana Cardoso accepted a new professional challenge and integrated, as a senior Investigator, the recently formed Neuronal Circuits and Behavior Group, led by Dr. João Peça. Her most recent work has been focused on understanding the crosstalk between the immune system and neuronal homeostasis mechanisms, with the ultimate goal of unveiling the role of stress-triggered neuroinflammatory events in synaptic architecture and in the development of neuropsychiatric disorders. In this context, she is currently supervising 2 Ph.D students and was recently awarded a three-year grant from the Bial Foundation to investigate the contribution of maternal separation during early-life to microglia-mediated synaptic sculpting. Ana Cardoso has published 48 peer-review publications, 9 of which as last/corresponding author, accumulating over 2400 citations (SCOPUS), which resulted in an h-index of 27 (SCOPUS). She has also attained competitive funding as Principal Investigator in the form of several grants from FCT, Bial Foundation and Takeda Pharmaceuticals.

Afiliação

Centro de Neurociências e Biologia Celular

Publicações

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Informação sobre artigos em revista, actualizada a 18-04-2024, a partir da plataforma CIÊNCIAVITAE.

IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development

Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Pinto, Maria J.; Reis, Tiago; Cardoso, Ana Maria; et al, Neuron. 3435 - 3449.e8. 21. 111. 2023. http://dx.doi.org/10.1016/j.neuron.2023.09.031 . 10.1016/j.neuron.2023.09.031 . Neuron

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia

Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; de Almeida, Luís Pereira; et al, International Journal of Molecular Sciences. 16. 24. 2023. http://dx.doi.org/10.3390/ijms241612603 . 10.3390/ijms241612603 . published International Journal of Molecular Sciences

ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microglia Cells

Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana Monteiro; Palmeira, Julys da Fonseca; Cardoso, Ana Luísa; Neves, Francisco de Assis Rocha; et al, Viruses. 6. 15. 2023. http://dx.doi.org/10.3390/v15061250 . 10.3390/v15061250 . published Viruses

Peripheral inflammatory markers during an acute bacterial infection in older patients with and without cognitive dysfunction: A case control study

Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana Luísa; Cardoso, Ana Maria; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim, Brain, Behavior, & Immunity - Health. 25. 2022. http://dx.doi.org/10.1016/j.bbih.2022.100503 . 10.1016/j.bbih.2022.100503 . published Brain, Behavior, & Immunity - Health

In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A cross-sectional controlled study

Silva, Ana Rita; Regueira, Patricia; Peres, André; Cardoso, Ana Luísa; Baldeiras, Inês; Santana, Isabel; Cerejeira, Joaquim, Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.984178 . 10.3389/fnagi.2022.984178 . published Frontiers in Aging Neuroscience

Microglia-dependent remodeling of neuronal circuits

Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica M.; Cardoso, Ana L.; Peça, João, Journal of Neurochemistry. 74 - 93. 2. 163. 2022. http://dx.doi.org/10.1111/jnc.15689 . 10.1111/jnc.15689 . published Journal of Neurochemistry

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations

Oliveira, Ana Rafaela; Martins, Solange; Cammarata, Giuseppe; Martins, Mariana; Cardoso, Ana Maria; Almeida, Maria Rosário; do Carmo Macário, Maria; et al, Biomedicines. 8. 10. 2022. http://dx.doi.org/10.3390/biomedicines10081905 . 10.3390/biomedicines10081905 . published Biomedicines

Cognitive trajectories following acute infection in older patients with and without cognitive impairment: an one-year follow-up study

Costa Silva, Ana Rita; Regueira, Patrícia; Cardoso, Ana; Baldeiras, Ines; Santana, Isabel; Cerejeira, Joaquim, Frontiers in Psychiatry. 2022. in press Frontiers in Psychiatry

The old guard: Age-related changes in microglia and their consequences

Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso, Mechanisms of Ageing and Development. 111512 - 111512. 197. 2021. https://doi.org/10.1016/j.mad.2021.111512 . 10.1016/j.mad.2021.111512 . Mechanisms of Ageing and Development

Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials

Sequeira, Diana; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo; Peça, João; Cardoso, Ana; Santos, João Miguel, Clinical Oral Investigations. 2021. accepted Clinical Oral Investigations

miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease

Barros-Viegas, Ana Teresa; Guedes, Joana; Cardoso, Ana Maria; Pereira de Almeida, Luís; Resende de Oliveira, Catarina; Pedro de Magalhães, João; Peça, João; Cardoso, Ana Luísa, Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . published Molecular Therapy - Nucleic Acids

Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling

Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Cardoso, Ana L.; Peça, João, Neuropsychopharmacology. 1438 - 1447. 9. 45. 2020. http://dx.doi.org/10.1038/s41386-020-0727-7 . 10.1038/s41386-020-0727-7 . published Neuropsychopharmacology

Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis

Silva, Ana Rita; Regueira, Patrícia; Albuquerque, Elisabete; Baldeiras, Inês; Cardoso, Ana Luísa; Santana, Isabel; Cerejeira, Joaquim, Journal of the American Medical Directors Association. 2020. http://dx.doi.org/10.1016/j.jamda.2020.08.017 . 10.1016/j.jamda.2020.08.017 . published Journal of the American Medical Directors Association

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Cardoso, Ana Luísa; Peça, João, Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications

Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells

Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A., Biochimica et Biophysica Acta - General Subjects. 2788 - 2796. 12. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS . 10.1016/j.bbagen.2018.08.014 . Biochimica et Biophysica Acta - General Subjects

Effects of a New Bioceramic Material on Human Apical Papilla Cells

Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João, Journal of Functional Biomaterials. 4. 9. 2018. http://dx.doi.org/10.3390/jfb9040074 . 10.3390/jfb9040074 . Journal of Functional Biomaterials

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; et al, Ageing Research Reviews. 214 - 277. 47. 2018. http://dx.doi.org/10.1016/j.arr.2018.07.004 IF=8.973 . 10.1016/j.arr.2018.07.004 . Ageing Research Reviews

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-ß and Tau Pathologies

Guedes, Joana R.; Lao, Taotao; Cardoso, Ana L.; El Khoury, Joseph, Frontiers in Neurology. 9. 2018. http://dx.doi.org/10.3389/fneur.2018.00549 IF=3.508 . 10.3389/fneur.2018.00549 . Frontiers in Neurology

miRNAs: New biomarkers and therapeutic targets in dementia

Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C., Current Pharmaceutical Design. 669 - 692. 5. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017530528&partnerID=MN8TOARS . 10.2174/1381612823666170111094702 . Current Pharmaceutical Design

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors

Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P., Human Molecular Genetics. 4375 - 4387. 22. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034256071&partnerID=MN8TOARS . 10.1093/hmg/ddx323 . Human Molecular Genetics

MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

Guedes, Joana R.; Santana, Isabel; Cunha, Catarina; Duro, Diana; Almeida, Maria R.; Cardoso, Ana M.; de Lima, Maria C. Pedroso; Cardoso, Ana L., Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 7 - 17. 3. 2016. http://dx.doi.org/10.1016/j.dadm.2015.11.004 . 10.1016/j.dadm.2015.11.004 . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

Cardoso, Ana L; Guedes, Joana R; de Lima, Maria C Pedroso, Current Opinion in Pharmacology. 1 - 9. 26. 2016. http://dx.doi.org/10.1016/j.coph.2015.09.001 IF=5.563 . 10.1016/j.coph.2015.09.001 . Current Opinion in Pharmacology

Frailty in mouse ageing: A conceptual approach

von Zglinicki, Thomas; Varela-Nieto, Isabel; Brites, Dora; Karagianni, Niki; Ortolano, Saida; Georgopoulos, Spiros; Cardoso, Ana Luisa; et al, Mechanisms of Ageing and Development. 34 - 40. 160. 2016. http://dx.doi.org/10.1016/j.mad.2016.07.004 IF=3.087 . 10.1016/j.mad.2016.07.004 . Mechanisms of Ageing and Development

CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells

Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al, Biochimica et Biophysica Acta - General Subjects. 28 - 35. 1. 1860. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS . 10.1016/j.bbagen.2015.09.021 . Biochimica et Biophysica Acta - General Subjects

Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression

Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., Molecular Pharmaceutics. 716 - 730. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS . 10.1021/mp5005349 . Molecular Pharmaceutics

MicroRNAs in Glioblastoma: Role in Pathogenesis and Opportunities for Targeted Therapies

Costa, Pedro; Cardoso, Ana; Mano, Miguel; Lima, Maria, CNS & Neurological Disorders - Drug Targets. 222 - 238. 2. 14. 2015. http://dx.doi.org/10.2174/1871527314666150116123610 IF=2.188 . 10.2174/1871527314666150116123610 . CNS & Neurological Disorders - Drug Targets

MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies

Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P., CNS and Neurological Disorders - Drug Targets. 222 - 238. 2. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma

Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C., Journal of Controlled Release. 31 - 39. 207. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS . 10.1016/j.jconrel.2015.04.002 . Journal of Controlled Release

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

Guedes, J.R.; Custódia, C.M.; Silva, R.J.; de Almeida, L.P.; de Lima, M.C.P.; Cardoso, A.L., Human Molecular Genetics. 6286 - 6301. 23. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926341070&partnerID=MN8TOARS . 10.1093/hmg/ddu348 . Human Molecular Genetics

Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery

Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B., Molecular Pharmaceutics. 819 - 827. 3. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS . 10.1021/mp400510a . Molecular Pharmaceutics

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al, Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 IF=6.425 . 10.1038/mtna.2013.30 . Molecular Therapy - Nucleic Acids

Involvement of MicroRNA in Microglia-Mediated Immune Response

Guedes, J.; Cardoso, A. L. C.; Pedroso de Lima, M. C., Clinical and Developmental Immunology. 1 - 11. 2013. 2013. http://dx.doi.org/10.1155/2013/186872 IF=2.934 . 10.1155/2013/186872 . Clinical and Developmental Immunology

Temperature-responsive cationic block copolymers as nanocarriers for gene delivery

Calejo, Maria Teresa; Cardoso, Ana Maria S.; Kjøniksen, Anna-Lena; Zhu, Kaizheng; Morais, Catarina M.; Sande, Sverre Arne; Cardoso, Ana Luísa; et al, International Journal of Pharmaceutics. 105 - 114. 1. 448. 2013. http://dx.doi.org/10.1016/j.ijpharm.2013.03.028 IF=3.785 . 10.1016/j.ijpharm.2013.03.028 . International Journal of Pharmaceutics

Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications

Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C., Current Pharmaceutical Design. 2895 - 2923. 16. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS . 10.2174/1381612811319160006 . Current Pharmaceutical Design

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma

Costa, P.M.; Cardoso, A.L.; Nóbrega, C.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de Lima, M.C., Human Molecular Genetics. 904 - 918. 5. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873438180&partnerID=MN8TOARS . 10.1093/hmg/dds496 . Human Molecular Genetics

Comparison of the efficiency of complexes based on S4<inf>13</inf>-PV cell-penetrating peptides in plasmid DNA and siRNA delivery

Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 2653 - 2666. 7. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS . 10.1021/mp400078h . Molecular Pharmaceutics

S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization

Cardoso, Ana M.S.; Trabulo, Sara; Cardoso, Ana L.; Lorents, Annely; Morais, Catarina M.; Gomes, Paula; Nunes, Cláudia; et al, Biochimica et Biophysica Acta (BBA) - Biomembranes. 877 - 888. 3. 1818. 2012. http://dx.doi.org/10.1016/j.bbamem.2011.12.022 IF=3.389 . 10.1016/j.bbamem.2011.12.022 . Biochimica et Biophysica Acta (BBA) - Biomembranes

PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma

Costa, P.M.; Cardoso, A.L.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de lima, M.C., Human Molecular Genetics. 5118 - 5130. 23. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869025536&partnerID=MN8TOARS . 10.1093/hmg/dds358 . Human Molecular Genetics

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

Cardoso, Ana L.; Guedes, Joana R.; Pereira de Almeida, Luís; Pedroso de Lima, Maria C., Immunology. 73 - 88. 1. 135. 2011. http://dx.doi.org/10.1111/j.1365-2567.2011.03514.x IF=3.705 . 10.1111/j.1365-2567.2011.03514.x . Immunology

Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents

Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 1120 - 1131. 4. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS . 10.1021/mp100426e . Molecular Pharmaceutics

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Trabulo, Sara; Cardoso, Ana Luísa; Mano, Miguel; De Lima, Maria C. Pedroso, Pharmaceuticals. 961 - 993. 4. 3. 2010. http://dx.doi.org/10.3390/ph3040961 . 10.3390/ph3040961 . Pharmaceuticals

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Controlled Release. 392 - 403. 3. 142. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349098528&partnerID=MN8TOARS . 10.1016/j.jconrel.2009.11.004 . Journal of Controlled Release

Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS

Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C., Journal of Controlled Release. 113 - 123. 2. 132. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349102126&partnerID=MN8TOARS . 10.1016/j.jconrel.2008.08.014 . Journal of Controlled Release

S4<inf>13</inf>-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA

Trabulo, S.; Mano, M.; Faneca, H.; Cardoso, A.L.; Duarte, S.; Henriques, A.; Paiva, A.; et al, Journal of Gene Medicine. 1210 - 1222. 11. 10. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149190435&partnerID=MN8TOARS . 10.1002/jgm.1247 . Journal of Gene Medicine

siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing

Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Gene Medicine. 170 - 183. 3. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS . 10.1002/jgm.1006 . Journal of Gene Medicine

Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System

P. de Lima, M.; Girao da Cruz, M.; C. Cardoso, A.; Simoes, S.; de Almeida, L., Current Drug Target -CNS & Neurological Disorders. 453 - 465. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546144 IF=3.236 . 10.2174/1568007054546144 . Current Drug Target -CNS & Neurological Disorders

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury

Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C, Gene Therapy. 1242 - 1252. 16. 12. 2005. http://dx.doi.org/10.1038/sj.gt.3302516 IF=5.18 . 10.1038/sj.gt.3302516 . Gene Therapy

5 47 de 47 Publicações

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Informação da exclusiva responsabilidade do investigador 18-04-2024 , a partir da plataforma CIÊNCIAVITAE.

2023/03/01 - 2026/02/28

Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits

2022.02604.PTDC

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2022/03/01 - 2023/03/31

BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids

EXPL/MED-OUT/1470/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2021/03/01 - 2022/12/31

Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations?

EN119

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Takeda Pharmaceuticals Asia Pacific Pte Ltd

2021/02/01 - 2024/01/31

Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies

PTDC/MED-NEU/5993/2020

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular; CNC.IBILI

Financiadores: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2023/04/30

Evaluation of TETO-OSKM lentiviral constructs in Dementia models

CSD1010A01#IV1010

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: YouthBio Therapeutics

2021/01/01 - 2023/12/31

Disease modelling of frontotemporal dementia in human brain organoids

PTDC/MEC-NEU/4814/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2019/01/15 - 2025/01/14

Unraveling miRNA contribution to neuroinflammation and dementia

DL 57/2016/CP1448/CT0023

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2018/07/26 - 2021/07/25

The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a case-control longitudinal study using imaging and molecular biomarkers

PTDC/MEC-PSQ/32501/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2016/01/01 - 2019/01/14

Understanding the contribution of miRNAs to neuroinflammation in Alzheimer´s disease

SFRH/BPD/108312/2015

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2016/04/01 - 2019/10/01

Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation

PTDC/NEU-SCC/3247/2014

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2013/03 - 2015/03

Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery

Provided by PTCRIS: 124488

Financiadores: Fundação para a Ciência e a Tecnologia, I.P.

2013/03/01 - 2015/08/31

Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease

PTDC/BIM-MEC/0651/2012

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2013/03/02 - 2015/06/01

Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery

PTDC/DTP-FTO/0265/2012

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2013/01/01 - 2014/12/31

PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013

PEst-C/SAU/LA0001/2013

Researcher

CNC.IBILI

Financiadores: Fundação para a Ciência e a Tecnologia

2009/01/01 - 2013/10/31

INFLAMMATORY MECHANISMS IN NEURODEGENERATION: MIRNAS AS REGULATORS OF THE IMMUNE SYSTEM RESPONSE IN ALZHEIMERS DISEASE

SFRH/BPD/46228/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2007/05/01 - 2010/12/31

Development of novel approaches for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins

PTDC/BIO/65627/2006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2005/01/01 - 2008/12/31

SILENCIAMENTO DE GENES PRÓ-APOPTÓTICOS PARA O TRATAMENTO DA LESÃO CEREBRAL: DESENVOLV. DE VECTORES DE BASE LIPÍDICA PARA POTENCIAR A ENTREGA DE SIRNA E DE GENES CODIFICADORES DE SIRNA NUM MODELO NEURONAL DE ISQUÉMIA

SFRH/BD/17216/2004

PhD Student Fellow

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

5 17 de 17 projetos

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