Elisabete Baptista Ferreiro

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E-mail
ebf@cnc.uc.pt

Visão Geral

Elisabete Ferreiro is currently an assistant researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, integrated in the group MitoXT - Mitochondrial Toxicology and Experimental Therapeutics, headed by Dr.Paulo Oliveira. Her main expertise area is in neuroscience and cell biology. She graduated in Biology from the University of Coimbra (UC), in 2002, and completed her PhD degree in Biology, also from UC, in 2008. Her PhD works led to the thesis 'Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s disease and Prion disorders'. During her PhD works, E. Ferreiro demonstrated the existence of endoplasmic reticulum (ER) stress as a major contribution for cell death induced by the amyloid beta (Abeta) peptide and PrP106–126, in both Alzheimer’s disease and Prion disorders. Besides, she further showed the relevance of the communication between the ER and the mitochondria for apopotic pathway. In 2008, E. Ferreiro started her post-doc research studies focused on identifying mechanisms involved in Alzheimer's disease (AD) and explore hippocampal adult neurogenesis along with signalling pathways with potential to improve upon it. In 2013, she initiated a second postdoctoral program (Center for Neuroscience and Cell Biology, University of Coimbra). During this period Elisabete Ferreiro studied the mitochondrial control of NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons, the positive value of Coriolus versicolor biomass in dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus and also evaluated whether hyperglycemia enhances Alzheimer´s disease pathology by perturbing adult hippocampal neurogenesis. In 2017 she spent 6 months at the Achucarro Basque Center (Spain), where she extended her knowledge on hippocampal neurogenesis, stem cells and consolidate her collaborations with experts in the field. Currently, she is interested in developing new therapeutic strategies and create personalized medicine platforms for Amyotrophic lateral sclerosis (ALS). In more detail, she is conducting research as principal investigator of funded projects to develop a innovative personalized medicine platform for ALS, based on human neuronal cell differentiated from urine-derived stem cells isolated from ALS patients' urine and test several drugs as potential therapeutic treatment of this disease. E. Ferreiro has been active in European networks, such as, COST action BM1402, As a result of her research activity, she has published 40 scientific papers in international peer reviewed journals, with over 3123 citations, an h index of 28 an i10 index of 33 and an accumulated impact factor of 189.466.

Afiliação

CNC-Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, (3004-504) Coimbra, Portugal; IIIUC - Institute for Interdisciplinary Research, University of Coimbra, (3030-789) Coimbra, Portugal

Publicações

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Informação sobre artigos em revista, actualizada a 23-06-2024, a partir da plataforma CIÊNCIAVITAE.

Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells

Ferreiro, Elisabete; Monteiro, Mariana; Pereira, Francisco; Barroso, Cristina; Egas, Conceição; Macedo, Paula; Valero, Jorge; Sardão, Vilma A.; Oliveira, Paulo J., Mechanisms of Ageing and Development. 218. 2024. http://dx.doi.org/10.1016/j.mad.2024.111912 . 10.1016/j.mad.2024.111912 . Mechanisms of Ageing and Development

Mitochondria: A Promising Convergent Target for the Treatment of Amyotrophic Lateral Sclerosis

Teresa Cunha-Oliveira; Liliana Montezinho; Rui F. Simões; Marcelo Carvalho; Elisabete Ferreiro; Filomena S. G. Silva, Cells. 2024. https://doi.org/10.3390/cells13030248 . 10.3390/cells13030248 . Cells

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Cavaleiro, C.; Afonso, G.J.M.; Oliveira, P.J.; Valero, J.; Mota, S.I.; Ferreiro, E., Frontiers in Molecular Neuroscience. 16. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85176442233&partnerID=MN8TOARS . 10.3389/fnmol.2023.1229728 . Frontiers in Molecular Neuroscience

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Gonçalo J. M. Afonso; Carla Cavaleiro; Jorge Valero; Sandra I. Mota; Elisabete Ferreiro, Cells. 2023. https://doi.org/10.3390/cells12131763 . 10.3390/cells12131763 . Cells

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints

Cunha-Oliveira, T.; Carvalho, M.; Sardão, V.; Ferreiro, E.; Mena, D.; Pereira, F.B.; Borges, F.; et al, Molecular Neurobiology. 6373 - 6396. 10. 59. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85135617163&partnerID=MN8TOARS . 10.1007/s12035-022-02980-7 . submitted Molecular Neurobiology

Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice

Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites, Cells. 2022. https://doi.org/10.3390/cells11010137 . 10.3390/cells11010137 . Cells

Targeting Neurogenesis with Mushroom Nutrition: A Mini Review

Elisabete Ferreiro; Tito Fernandes, Clinical Journal of Mycology Vol VI Edition 1.. 1. 6. 2022. https://doi.org/10.54225/cjm.vol6.2.35294 . 10.54225/cjm.vol6.2.35294 . Clinical Journal of Mycology Vol VI Edition 1.

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A 2A receptor: Interaction with brain-derived neurotrophic factor

Filipa F. Ribeiro; Filipa Ferreira; Rui S. Rodrigues; Rita Soares; Diogo M. Pedro; Marta Duarte-Samartinho; Rita I. Aroeira; et al, STEM CELLS. 1362 - 1381. 10. 39. 2021. https://doi.org/10.1002/stem.3421 . 10.1002/stem.3421 . STEM CELLS

Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy

Carvalhais, Lia G.; Martinho, Vera C.; Ferreiro, Elisabete; Pinheiro, Paulo S., Frontiers in Neuroscience. 14. 2021. http://dx.doi.org/10.3389/fnins.2020.578409 . 10.3389/fnins.2020.578409 . Frontiers in Neuroscience

miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease

Barros-Viegas, A.T.; Carmona, V.; Ferreiro, E.; Guedes, J.; Cardoso, A.M.; Cunha, P.; Pereira de Almeida, L.; et al, Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079208982&partnerID=MN8TOARS . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids

Chronic Hyperglycemia Impairs Hippocampal Neurogenesis and Memory in an Alzheimer’s disease mouse model

Ferreiro, Elisabete; Mariagrazia Lanzillo; Diogo Canhoto; António Silva; Sandra Isabel Mota; Inês Dias; Ildete Luísa Ferreira; et al, Neurobiology of Aging. 2020. http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003 . 10.1016/j.neurobiolaging.2020.04.003 . Neurobiology of Aging

Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields

Dioli, C.; Patrício, P.; Sousa, N.; Kokras, N.; Dalla, C.; Guerreiro, S.; Santos-Silva, M.A.; et al, Translational Psychiatry. 1. 9. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064910305&partnerID=MN8TOARS . 10.1038/s41398-019-0477-7 . Translational Psychiatry

Histamine modulates hippocampal inflammation and neurogenesis in adult mice

Saraiva, C.; Barata-Antunes, S.; Santos, T.; Ferreiro, E.; Cristóvão, A.C.; Serra-Almeida, C.; Ferreira, R.; Bernardino, L., Scientific Reports. 1. 9. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067204850&partnerID=MN8TOARS . 10.1038/s41598-019-44816-w . Scientific Reports

Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus

Ferreiro, E.; Pita, I.R.; Mota, S.I.; Valero, J.; Ferreira, N.R.; Fernandes, T.; Calabrese, V.; et al, Oncotarget. 32929 - 32942. 68. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052580513&partnerID=MN8TOARS . 10.18632/oncotarget.25978 . Oncotarget

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease

Silva, A.C.; Ferreira, I.L.; Hayden, M.R.; Ferreiro, E.; Rego, A.C., Biochimica et Biophysica Acta - Molecular Basis of Disease. 34 - 44. 1. 1864. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031746642&partnerID=MN8TOARS . 10.1016/j.bbadis.2017.09.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondrial Ca<sup>2+</sup>handling in Huntington's and Alzheimer's diseases – Role of ER-mitochondria crosstalk

Naia, L.; Ferreira, I.L.; Ferreiro, E.; Rego, A.C., Biochemical and Biophysical Research Communications. 1069 - 1077. 4. 483. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998772500&partnerID=MN8TOARS . 10.1016/j.bbrc.2016.07.122 . Biochemical and Biophysical Research Communications

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

Robledinos-Antón, N.; Rojo, A.I.; Ferreiro, E.; Núñez, Á.; Krause, K.-H.; Jaquet, V.; Cuadrado, A., Redox Biology. 393 - 401. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021413702&partnerID=MN8TOARS . 10.1016/j.redox.2017.06.010 . Redox Biology

Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

Dioli, C.; Patrício, P.; Trindade, R.; Pinto, L.G.; Silva, J.M.; Morais, M.; Ferreiro, E.; et al, Molecular Psychiatry. 1110 - 1118. 8. 22. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026899195&partnerID=MN8TOARS . 10.1038/mp.2017.103 . Molecular Psychiatry

Interventions for age-related diseases: Shifting the paradigm

Figueira, I.; Fernandes, A.; Mladenovic Djordjevic, A.; Lopez-Contreras, A.; Henriques, C.M.; Selman, C.; Ferreiro, E.; et al, Mechanisms of Ageing and Development. 69 - 92. 160. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999035290&partnerID=MN8TOARS . 10.1016/j.mad.2016.09.009 . Mechanisms of Ageing and Development

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A., Neurobiology of Aging. 84 - 95. 46. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2016.06.012 . Neurobiology of Aging

Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease

Monteiro-Cardoso, V.F.; Oliveira, M.M.; Melo, T.; Domingues, M.R.M.; Moreira, P.I.; Ferreiro, E.; Peixoto, F.; Videira, R.A., Journal of Alzheimer's Disease. 1375 - 1392. 4. 43. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919926803&partnerID=MN8TOARS . 10.3233/JAD-141002 . Journal of Alzheimer's Disease

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway

Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., Experimental Neurology. 698 - 709. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.07.023 . Experimental Neurology

Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F., Neurochemical Research. 797 - 806. 4. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS . 10.1007/s11064-013-0982-7 . Neurochemical Research

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons

Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice

Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F., Neuroscience. 256 - 266. 220. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.06.029 . Neuroscience

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers

Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R., International Journal of Cell Biology. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS . 10.1155/2012/735206 . International Journal of Cell Biology

Endoplasmic reticulum stress: A new playER in tauopathies

Ferreiro, E.; Pereira, C.M.F., Journal of Pathology. 687 - 692. 5. 226. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS . 10.1002/path.3977 . Journal of Pathology

Multiple defects in energy metabolism in Alzheimer's disease

Ferreira, I.L.; Resende, R.; Ferreiro, E.; Rego, A.C.; Pereira, C.F., Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957994659&partnerID=MN8TOARS . Current Drug Targets

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R., Journal of Neuroscience Research. 2091 - 2099. 9. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS . 10.1002/jnr.21648 . Journal of Neuroscience Research

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Disease. 331 - 342. 3. 30. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS . 10.1016/j.nbd.2008.02.003 . Neurobiology of Disease

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C., Neuroscience. 725 - 737. 3. 155. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.06.036 . Neuroscience

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, E.; Eufrásio, A.; Pereira, C.; Oliveira, C.R.; Rego, A.C., Journal of Alzheimer's Disease. 223 - 228. 3. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549064191&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

Role of endoplasmic reticulum-mediated apoptotic pathway in Ab toxicity

Ferreiro, Elisabete; Rui O Costa; Sueli Marques; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira, Cognitive Sciences at the Leading Edge. 1 - 26. 2. 2007. published Cognitive Sciences at the Leading Edge

Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?

Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia, Journal of Neurochemistry. 68 - 69. Supplement. 102. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162 . published Journal of Neurochemistry

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease

Mechanism of amyloid-beta induced early synaptotoxicity.

Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia, Sinapse. 101 - 101. 1. 5 . 2005. published Sinapse

Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neuroscience Research. 872 - 880. 6. 76. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS . 10.1002/jnr.20135 . Journal of Neuroscience Research

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . Journal of Molecular Neuroscience

Todos os projectos

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Informação da exclusiva responsabilidade do investigador 23-06-2024 , a partir da plataforma CIÊNCIAVITAE.

2024/01/01 - 2026/12/29

Cooperation and technological transfer for the development of a new platform precision medicine for Amyotrophic Lateral Sclerosis

361_Cross-3DTool-4ALS_3_P

Principal investigator

Universidade de Coimbra; Universidad de Salamanca

Financiadores: European Regional Development Fund

2023/03/01 - 2024/08/31

Diferentes localizações intracelulares da cinase AMPK modulam os contactos mitocôndria-retículo endoplasmático

2022.04407.PTDC

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2022/01/02 - 2023/07/01

BraveHEART: Improvig Nature by Addressing Bioactive Dietary Polyphenols to Mitochondria for the Protection of Cardiac Complications in Non-Alcoholic Fatty Liver Disease

EXPL/BIA-BQM/1361/2021

Researcher

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2022/01/01 - 2023/06/30

Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis

EXPL/BTM-TEC/1407/2021

Researcher

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2022/01/15 - 2025/01/14

Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis

PTDC/BTM-ORG/0055/2021

Principal investigator

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2022/01/01 - 2023/06/30

Mitochondria as potential drivers of sex-specific microglia dysfunctional remodelling and anxiety caused by prenatal stress

EXPL/MED-NEU/1002/2021

Researcher

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2020/01/01 - 2023/12/31

Center for Innovative Biomedicine and Biotechnology

UIDB/04539/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2019/03/01 - 2025/02/28

Modulation of adult hippocampal neurogenic reserve for the prevention of cognitive decline in diabetic-like Alzheimer´s disease

CEECIND/00322/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2019/03/01 - 2021/11/01

Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype

PTDC/MED-FAR/29391/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2017/01/01 - 2019/12/31

The influence of maternal bonding in neuroimmune synaptic sculpting

264/2016

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação Bial

2016/06/01 - 2019/02/28

Beta catenin as modulator of neurogenesis and memory enhancer in diabetic-like Alzheimer´s disease mouse model

SFRH / BPD / 86551 / 2012

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2016/06/01 - 2019/02/28

Beta catenin as modulator of neurogenesis and memory enhancer in diabetic-like Alzheimer´s disease mouse model

SFRH / BPD / 86551 / 2012

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2016/12/01 - 2017/09/30

Supplementation of Coriolus versicolor (biomass) - a nutritional presymptomatic approach against cognitive deficits

--

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Mycology Research Laboratories (MRL) Ltd.

2016/01/01 - 2017/01/01

Modified hippocampal neurogenesis and cognitive function in a mouse model of Alzheimers disease subjected to chronic hyperglycemia

FMUC-BST-2016/20

Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Banco Santander Totta

2014/04/01 - 2015/09/30

Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory

EXPL/NEU-SCC/1193/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2011/01/01 - 2013/12/31

Interaction between endoplasmic reticulum stress-mediated endothelial dysfunction and hippocampal neurogenesis. Potential therapeutic target for the treatment of Alzheimer´s disease

PrémioPfizerSPN2010

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Pfizer Portugal

2010/04/01 - 2013/03/31

Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis: new targets for brain repair therapies

PTDC/SAU-NEU/101783/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2010/04/01 - 2013/06/30

Papel da comunicação intercelular entre células endoteliais e celulas estaminais neurais na "stemness" e a neurogénese: novos alvos terapeuticos para a reparação cerebral

PTDC/SAU-NEU/101783/2008

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2009/01/01 - 2011/12/31

Early Diagnosis of Alzheimer´s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools

PIC/IC/83206/2007

Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Fundação para a Ciência e a Tecnologia

2009/01/01 - 2012/06/30

Diagnóstico precoce de Doença de Alzheimer: avaliação de critérios de classificação recentes e exploração de novos instrumentos de estudo

PIC/IC/83206/2007

Universidade de Coimbra; Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2008/10 - 2012/05

Interplay between vascular degeneration and hippocampal neurogenesis in Alzheimer's disease: the role of amyloid-ß-induced ER stress

SFRH/BPD/4336/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2007/10 - 2010/09

Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease

PTDC/SAU-NEU/71675/2006

Financiadores: Fundação para a Ciência e a Tecnologia

2007/10/01 - 2010/09/30

Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease

PTDC/SAU-NEU/71675/2006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Financiadores: Fundação para a Ciência e a Tecnologia

2006/01/01 - 2007/12/31

Signalling pathways involved in the cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease neurodegeneration

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Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Universidade de Coimbra Instituto de Investigação Interdisciplinar

2003/10/01 - 2004/09/30

Intraneuronal accumulation of amyloid-beta

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Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Universidade de Coimbra Faculdade de Medicina

2003/10 - 2008/01

Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides: implications for the etiopathogenesis of Alzheimer's disease and prion disorders

SFRH/BD/14108/2003

PhD Student Fellow

Financiadores: Fundação para a Ciência e a Tecnologia

2002/11/01 - 2004/10/31

Role of exocytotic presynaptic proteins in synaptic apoptosis induced by amyloid-beta

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Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Universidade de Coimbra Faculdade de Medicina

2002/11/01 - 2004/10/31

Role of exocytotic presynaptic proteins in synaptic apoptosis induced by amyloid-beta

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Researcher

Universidade de Coimbra Faculdade de Medicina

Financiadores: Universidade de Coimbra Faculdade de Medicina

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