João Laranjinha is professor of Biochemistry and Molecular Biology at the Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. He graduated in Pharmaceutical Sciences (University of Coimbra) in 1984 and got a PhD in Biochemistry (University of Coimbra) in 1996. He did Postdoc studies with Enrique Cadenas in 1997-1998 at the Dept. Molecular Pharmacology and Toxicology, University Southern California, Los Angeles, USA, studying Free Radicals and Antioxidants in Biology. His research is focused on the functional impact of nitric oxide in the brain as a neurometabolic regulator and as a mediator of neurovascular coupling with impact in aging and neurodegeneration. He is also interested in dietary nitrite-driven regulatory processes, encompassing the non-enzymatic production of nitric oxide along the nitrate:nitrite:NO pathway. He has been awarded several prizes, including the Science and Humanity award by The Oxygen Club of California and is member of the editorial board of major journals in his area of research, including Redox Biology, Free Radical Biology and Medicine, Archives of Biochemistry and Biophysics, Free Radical Research and Biofactors. He has chaired the organizing and scientific committees of several international conferences, including the European (SFRRE 2007) and International (SFRRI 2018) meetings of the Society for Free Radical Research. He has been member of the council of the European Society for Neurochemistry and the European Society for Free Radical Research for several years and President of the Portuguese Biochemical Society (2014-18). Currently, he serves as member of the Advanced Courses Committee of FEBS and as the president of the General Assembly of the Portuguese Biochemical Society.
Positions
1984-1984 Monitor, Faculty of Pharmacy, University of Coimbra
1984-1989 Teaching-Assistant of Biochemistry, Faculty of Pharmacy, University of Coimbra
1989-1996 Assistant of Biochemistry, Faculty of Pharmacy, University of Coimbra
1994- Researcher of the Center for Neurosciences and Cell Biology, Univ. Coimbra
1996-2005 Assistant-Professor of Biochemistry, Faculty of Pharmacy, University of Coimbra
1997-1998 Post-doctoral Research Fellow, Dept. Molecular Pharmacology & Toxicology, University Southern California, Los Angeles, USA
2005- Associate Professor, Faculty of Pharmacy, University of Coimbra.
2004- Group leader: Redox Biology and Brain Sensing, Center for Neurosciences and Cell Biology (CNC), Coimbra
2005 - Coordinator of the Oxidative Stress group of the Portuguese Biochemical Society
2005 - Director of the Center for Sensor Technology – Coimbra Labs Divison. (University of Kentucky, Lexington, USA)
2005 - Member of the Scientific Advisory Board of Institute for Oxidative Stress International
2005-2006 Secretary General of the General Assembly of Portuguese Biochemical Society
2007-2010 Member of the European Committee of the Society for Free Radical Research
2015-2018 Member of the European Committee of the Society for Free Radical Research
2008-2016 Member of the Council of the European Society for Neurochemistry
2008-2012 Secretary General of the Portuguese Biochemical Society
7/2012 - 6/2013 Member of the New York Academy of Sciences
2012-2014 Member board of Directors of Center for Neurosciences and Cell Biology, Coimbra
2012- Coordinator of the Vivarium of the Center for Neurosciences, University of Coimbra
2013- 2015 Vice-President of the Portuguese Biochemical Society
2013- Member of the Publication Committee of “Free Radical Biology and Medicine”
2013 Full Professor, Faculty of Pharmacy, University of Coimbra
2013 Editorial board “Redox Biology”
2014- Editorial board Free Radical Biology and Medicine
2014- Editorial board Archives of Biochemistry and Biophysics
2015- Editorial board Free Radical Research
2014- Vice President Assembly Faculty Pharmacy University of Coimbra
2014- 2016 Coordinator Group Biological and Bioanalytical Sciences, Faculty Pharmacy, University of Coimbra
2015- Member of the Advisory Board of Oxygen Club California
2015 - 2018 President of the Portuguese Biochemical Society
2015 - 2018 Member of the Council of the Federation of European Biochemical Societies (FEBS)
2015 - Lifetime Honorary Member, The Oxygen Club of California
2016- 2016 Member of the Biennial Program Committee of the International Society for Neurochemistry (ISN)
2017 - Coordinator Doctoral Programme, Faculty Pharmacy, University of Coimbra
2018 - Member of the External Advisory Committee, IBSAL, Instituto de Investigación Biomédica, Salamanca, Spain
2019 - 2022 President of the General Assembly of the Portuguese Biochemical Society.
2019 - Member elected for Advanced Courses Committee of the Federation of European Biochemical Societies (FEBS)
2019 - Member of the PABMB committee on Congresses and Symposia
2019 - Editorial board of Biofactors
2019 - Member of the board of directors of Center for Neurosciences and Cell Biology (University of Coimbra)
2021- Coordinator Department Biochemistry and Biology, Faculty Pharmacy, University of Coimbra
2022- Editorial board of Redox Biochemistry and Chemistry
2023 - Associate Editor Frontiers Molecular Neurosciences
Professional Societies
Portuguese Biochemical Society (Past President)
Society for Free Radical Research (SFRR) (Europe)
Oxygen Club California (USA)
Society for Free Radical Biology & Medicine
European Society for Neurochemistry
Coordination of Externally Funded Research Projects
Photooxidation of Human Low Density Lipoproteins (LDL) by Sensitizers Used in Photodynamic Therapy. Inhibition by Phenolic Antioxidants and Effects on Cells. Portuguese Science and Tecnology Foundation. October 1998 – October 2001.
Nitric Oxide and Dopamine-mediated damage to mitochondria in neuronal degeneration. Portuguese Science and Technology Foundation. March 1999 – March 2001.
Dynamic interactions of phenolic compounds from wine and olive oil in plasma and lipoproteins with relevance for atherosclerosis prevention. Portuguese Science and Technology Foundation and European Funds for Regional Development. June 2002 - June 2006.
Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration. Portuguese Science and Technology Foundation and European Funds for Regional Development. March 2002 - October 2005.
New biological functions for wine polyphenols: cellular and anti-inflammatory actions via nitric oxide production from nitrite.Portuguese Science and Technology Foundation and European Funds for Regional Development. May 2007 - May 2010.
Neurovascular coupling between neuronal activity and blood flow in brain mediated by nitric oxide. Implications in Alzheimer disease.Portuguese Science and Technology Foundation. 2010-2013.
In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging.Portuguese Science and Technology Foundation. 2010-2013.
Nitrate:Nitrite:Nitric oxide as a key pathway in gastrointestinal and cardiovascular physiology: uncovering new health properties of red wine and olive oil. Portuguese Science and Technology Foundation. 2011-2014.
Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis. Portuguese Science and Technology Foundation. 2013-2015.
Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism-based approach driven by nitrite and ascorbic acid from diet. Portuguese Science and Technology Foundation. 2018-2021.
The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study.
Portuguese Science and Technology Foundation. 2023-2026.
Invited lectures and conferences
More than 65, including invited lectures in major international congresses in Spain, Germany, Uruguay, Italy, Brazil, USA, Turkey, Switzerland, Argentina, France, India, Serbia, Slovakia, United Kingdom and Japan.
Relevant invited lectures:
Reduction of ferrylmyoglobin by dietary phenolic acids: prevention of low density lipoprotein oxidation. International Symposium on “Antioxidants, Inflammation, Cardiovascular and Ophtalmic Diseases. Biochemical and Clinical Studies on the Effects of Antioxidants on Lipoprotein and Hemoprotein Oxidation”. Valencia (Spain) September 30 - October 2, 1993.
Interaction of dietary hydroxycinnamic acid derivatives with ferrylmyoglobin: antioxidant activity towards LDL oxidation. Annual Joint Meeting University of California at Berkeley and University of Southern California “Oxidants & Antioxidants in Biology. New Developments in Research and Health Effects”. A meeting in honor of Paul Hochstein. Pasadena, California (USA) February 4-5, 1994.
Redox cycles of caffeic acid during the oxidation of LDL. Oxygen Club of California. 1999 World Congress. On Oxidants and Antioxidants in Biology. Santa Barbara, California, (USA) March 3-6, 1999.
Dynamic interplay of phenolic acids and ascorbate in the protection of LDL against oxidation. Society for Free Radical Research (SFRR) Europe Winter Meeting: Bio-flavonoids and polyphenols in health and disease. Dinard (France) Dec. 2-5, 1999.
Reaction of nitric oxide with dihydroxyphenylacetic acid: inhibition of mitochondrial respiratory chain. 10th Biennial Meeting of the Society for Free Radical Research International (SFRRI 2000). Kyoto (Japan), 16-20 October, 2000.
Superoxide dismutase stimulates the oxidation of dopamine metabolites by nitric oxide. Winter meeting of the Society for Free Radical Research – Europe. Valencia (Spain) Nov. 30 – Dec. 2, 2000.
Real-time monitoring of nitric oxide in rat hippocampal brain slices. XIth Meeting of the Society for Free Radical Research International. Paris (France) July 16-20, 2002.
Selective measurement of nitric oxide in rat hippocampal brain slices. VII Reunión del Grupo Espanol de Radicales Libres y III Reunión Iberoamericana. Cáceres (Espana) 26-28 Septiembre, 2002.
Selective measurement of nitric oxide production evoked by glutamate agonists in rat hippocampal brain slices. Oxygen Club California and University of Cádiz meeting on “Oxidants and Antioxidants in Biology”, Cádiz (Spain) February 6-9, 2003.
Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of NMDA glutamate receptor using electrochemical microsensors. Inaugural Symposium of Center for Free Radical and Biomedical Research. Facultad de Medicina, Universidad de la República, Montevideo (Uruguay) May 4, 2004.
Subregional concentration dynamics of nitric oxide in hippocampal slices evoked by stimulation of glutamate NMDA receptor. Biennial Meeting of the Society for Free Radical Research International. Buenos Aires (Argentina) May 5-9, 2004.
Redox activity of phenolic antioxidants and the potential benefits for human health. 2nd Spanish and Portuguese Congress on Free Radicals, Leioa-Bizkaia (Spain), November 25-27, 2004.
Nitric oxide dynamics in hippocampus following activation of NMDA and AMPA receptors. Oxygen Club California and University of Turin meeting “Oxidants and Antioxidants in Biology”. Alba (Italy) 7-10 September 2005.
Gastric nitric oxide: production and biological impact. VIII Reunión del Grupo Espanol de Radicales Libres. Valencia (Spain). January 31 – February 1, 2007.
Monitoring brain nitric oxide formation and respiration. 17th European Society for Neurochemistry Meeting – 3rd Conference on Advances in Molecular Mechanisms of Disease. Salamanca (Spain). May 19-22, 2007.
Dynamics of nitric oxide and oxygen changes in the hippocampus. V meeting of Society Free Radical Biology and Medicine – South American Group. V International Conference on Peroxynitrite and Reactive Nitrogen Species. Montevideo (Uruguay) September 2-6, 2007.
Nitrite in nitric oxide biology in the stomach: impact of red wine. Society for Free Radical Research Europe Meeting 2008, Free Radicals and Nutrition; Basic Mechanisms and Clinical Application. Berlin (Germany) July-5-9, 2008.
Translation of chemical properties of polyphenols into biological activity with impact in human health. XXIV International Conference on Polyphenols (ICP2008) Salamanca (Spain) 8-11 July 2008.
Molecular mechanisms inherent to neuromodulation: the role of nitric oxide. Conferência na Facultad de Medicina, Universidade de la Republica, Montevideo (Uruguay) 20- 26 Abril, 2009.
Nitric oxide mediates the neurovascular coupling between neuronal activity and blood flow in the brain: quantitative, direct and in vivo evidence. Society for Free Radical research Europe (SFRRe) meeting. Rome (Italy) August 26-29, 2009.
Wireless free radical connections in the brain: nitric oxide dynamics couples neuronal activity with local microcirculation. Seminário apresentado no Centro Biología Molecular “Severo Ochoa” Madrid (Spain). 10 November 2010.
Neuronal control of brain blood flow: nitric oxide is the neurovascular mediator with impact in Alzheimer´s disease. Society for Free Radical Research Europe meeting (Redox Biology and micronutrients: from signaling to translation and back). Istanbul, (Turkey), September 7-10, 2011.
Volume signaling in the brain: The proof of concept that neuronal nitric oxide regulates the cerebral microcirculation during neural activity. II International Conference on Environmental Stressors in Biology and Medicine. Siena, (Italy), 5-7 October 2011.
Neurovascular coupling in normal and Alzheimer´s rat brain: the direct role of nitric oxide. International Symposium on Redox Signaling and Oxidative Stress in Health and Disease (IV Spanish and Portuguese meeting on free radicals). Valencia (Spain) 5-7thJune 2012.
Neurovascular and metabolic coupling: diffusible bridging supported by nitric oxide. 16th Biennial Meeting of the Society for Free Radical Research International (SFRRI), 6-9 September 2012, London, (United Kingdom).
Neurovascular coupling in brain aging and neurodegeneration: a neuronal nitric oxide-driven process. GORDON RESEARCH CONFERENCE on the metabolic-inflammatory axis in brain aging and Alzheimer´s disease. April 14-19, 2013 Les Diablerets (Switzerland).
Neurovascular coupling mediated by nitric oxide in the brain: impact in aging and Alzheimer´s disease. 7th International Symposium on Experimental and Clinical Neurobiology (Slovak Academy of Sciences). June 23-27, 2013, Kosice (Slovakia).
Neurovascular coupling: a self-controlled mechanism critical for brain function prone to dysfunction in Alzheimer´s disease and during aging. VIII Intrenational Congresso of the Society for Free Radical Biology and Medicine – South American Group. October 14-17, 2013, Buenos Aires (Argentina).
The nitrate:nitrite:nitric oxide and signaling pathways in the gut: the prominet role of polyphenols. VI International Conference on Polyphenols and Health. October 16-19, 2013, Buenos Aires (Argentina).
Coupling neuronal activity with local blood flow in normal and Alzheimer´s rat brain: the direct role of nitric oxide. XII Congress Panamerican Association for Biochemistry and Molecular Biology (PABMB). November 9-14, 2013 Puerto Varas (Chile).
Dysfunctional nitric oxide-mediated neurovascular coupling in Alzheimer´s disease and aging. International Sympoisum on Redox Signaling in Biology & Medicine. X Meeting of the Spanish group of Free Radical Research. June 2-4, 2014 Valencia (Spain).
Neurovascular coupling mediated by nitric oxide: mechanisms in Alzheimer disease, aging and metabolic acidosis. 40th Congress of the Federation European Biochemical Societies (FEBS), The Biochemical basis of life. July 4-9, 2015 Berlin (Germany).
Nitric oxide-mediated neurovascular coupling in healthy and diseased brain: sources, mechanisms and significance. 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual meeting of the Brazilian Society for Biochemistry and Molecular Biology. August 24-28, 2015 Foz do Iguaçu, (Brazil).
Nitrite supports neurovascular coupling via redox coupling with ascorbate. Meeting of the Society for Free Radical Research, Europe (SFRRe) and The Society of Nutrition and Food Science. “Redox Biology meets Nutrition”. September 2-4, 2015 Stuttgart, (Germany).
Neurovascular coupling mediated by nitric oxide in hippocampus: functional communication with ascorbate and nitrite. Oxygen Club California (OCC) World Congress, “Redox Medicine and Nutrition”. May 4-6, 2016 Davis, CA, (USA).
Nitric oxide in the brain: neuromodulatory roles in the hippocampus in health, disease and aging. COST Action BM1203, meeting in Lisbon April 11-13, 2016 (Portugal).
Neurometabolic coupling in hippocampus mediated by neuronal-derived nitric oxide. 5th International Iberian Biophysics Congress. Porto, June 15-17, 2016 (Portugal).
Neurovascular coupling in brain aging and neurodegeneration: nitric oxide-mediated mechanisms and technological approaches. Jagiellonian Centre for Experimental Therapeutics (JCET) October 22, 2016 Kraków (Poland).
Regulation of neurovascular coupling in the brain by nitrite. Oxygen Club California (OCC) and Society for Free Radical Research Europe (SFFRE) meeting “Metabolic Stress and Redox Regulation”. Berlin, June 21-23, 2017 (Germany).
Nitric oxide mediated mechanisms in alzheimer´s disease. 8th International Congress of Pathophysiology. Bratislava, September 5-8, 2018 (Slovakia).
Role of nitric oxide in neurovascular coupling: consequences for aging and neurodegeneration. 10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide. Oxford, September 16-20, 2018 (United Kingdom).
Neurovascular coupling mediated by neuronal nitric oxide in hippocampus might be sustained by ascorbate and nitrite under hypoxia. 4th International Congress of the Serbian Society for Mitochondrial and Free Radical Research. Belgrade, September 28-30, 2018 (Serbia).
Redox regulation of neurovascular-neuroenergetic coupling axis by nitric oxide in animal models of aging and neurodegeneration. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI2019). Coimbra 22-24 May 2019 (Portugal).
Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling. 1st International Meeting of the Portuguese Society of Physiology. ISCTE IUL, Lisboa 10-11 October 2019 (Portugal)
Neurovascular coupling mediated by neuronal nitric oxide in rodent models of dementia, aging and neurodegeneration: modulation by nitrite via redox cycle with ascorbate. Annual Meeting and Conference of Society for Free Radical Research India 2020 on “Role and management of oxidative stress in human disease”. Mumbai, February 12-15, 2020 (India).
Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration. 20th Biennial Meeting of the Society for Free Radical Research International (SFRRI). March 15-18 2021 (online Congress).
The neurovascular-neuroenergetic axis in aging and neurodegeneration: the key role of nitric oxide. Plenary lecture at XXI National Congress of Portuguese Biochemical Society. Évora, 14-16 Outubro 2021 (Portugal).
Modulation of neurovascular coupling in the brain by nitric oxide and cognitive enhancement. II Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Diseases. March 3-5, 2022 Seville, Spain (online).
Regulation of neurovascular coupling by nitric oxide during aging and neurodegenerative conditions: the role of dietary nitrate on cognitive enhancement. Satellite Symposium of FENS 2022 Congress on the crucial balance of NO signaling – from synapse to disease. July 9-11, 2022. Paris (France).
Cognitive enhancement in aging: a redox biology hypothesis. Joint IUBMB/FEBS Advanced Lecture Course 2022 on Molecular targets for anti-aging interventions. 26 September- 1 October, 2022, Spetses Island, Greece.
Remodelling the neurovascular unit to improve cognition: a molecular hypothesis. European Society of Neurosonology and Cerebral Hemodynamics (26th Meeting of ESNCH). 14-16th October 2022. Lisbon, Portugal.
Redox regulation of neurovascular coupling by nitric oxide to improve cognition. Antio.it – Redox Webinar Series (online) on "Oxidative stress as a therapeutic target: from neurodegeneration to sickle cell disease". December 15, 2022 Italy.
Cognitive enhancement in aging and neurodegeneration: a molecular mechanism tuning and environmental pollutant into a critical brain mediator. II TOXRUN International Congress. April, Porto, 2023.
Redox regulation of neurovascular coupling by nitric oxide to improve cognition in aging and neurodegeneration. 1st FEBS (Federation of European Biochemical Societies) Redox Medicine workshop. May 22-25, 2023, Luso, Portugal.
Relevant publications
Chapters in Books
João Laranjinha (2001) Caffeic acid and related compounds: biochemical and cellular effects. In: Handbook of Antioxidants. Biochemical, Nutritional and Clinical Aspects, 2nd edition, (Cadenas E. and Packer L. Eds.) Marcel Dekker Inc., New York. pp. 279-302.
Bruno Gago and João Laranjinha. (2004) Caffeic acid-driven formation of nitric oxide from nitrite. In Polyphenols Communications 2004 (Eds. Antti Hoikkala and Otto Soidinsalo), Groupe Polyphenols, Helsinki, Finland, pp. 261-262.
João Frade, Ana Ledo, Carla Nunes, Rui Barbosa and João Laranjinha (2008) Nitric oxide in neurodegenerative pathways. In Free Radical Pathophysiology, Eds. Sílvia Alvarez and Pablo Evelson. Transworld Research Network, Kerala, Índia.
João Laranjinha, Oxidative Stress: from the 80’s to recent update (2008) in OXIDATIVE STRESS, INFLAMMATION AND ANGIOGENESIS IN THE METABOLIC SYNDROME, Raquel Soares Ed. Springer, USA.
João Laranjinha. Translation of chemical properties of polyphenols into biological activity with impact in human health in RECENT ADVANCES IN POLYPHENOL RESEARCH, VOL 2, pp.269-278. Santos-Buelga C., Escribano-Bailon MT, and Lattanzio V. Eds. Wiley-Blackwell & Sons, Ltd, UK (2010).
Frade JG, Fernandez C, Ledo A, Barbosa RM, Laranjinha J (2012). The modulation of glutamate NMDA receptor activity by etanol and polyphenols. In A Toxicological and Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level. Volume in the area of In Vitro Systems & the Toxic Effect of Chemicals edited by Research Signpost, Transworld Research Network.
Cátia F. Lourenço, Ana Ledo, Rui M. Barbosa and João Laranjinha (2016) Neurovascular coupling mediated by neuronal-derived nitric oxide: mechanisms in health and dysfunction with impact in aging and Alzheimer´s disease in The Biochemistry of Oxidative Stress. Physiopathology and Clinical Aspects Eds: Ricardo J. Gelpi, Alberto Boveris and Juan J. Poderoso. Springer, New York, USA.
Ledo, A., Rocha, B., Laranjinha, J. (2019) Bioactive lipids and the gut-brain-axis: diet as a modulator of bioactivity and diversity of lipids in the brain.
In Bioactive Lipids in Health and Disease, Homero Rubbo (Ed), Springer, New York, USA.
Major papers in International peer-reviewed journals
Laranjinha, J., Almeida, L. and Madeira, V. (1992) Lipid peroxidation and its inhibition in low density lipoproteins: quenching of cis-parinaric acid fluorescence. Archives of Biochemistry and Biophysics 297, 147-154.
Laranjinha, J., Almeida, L. and Madeira, V. (1994) Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochemical Pharmacology 48, 487-494.
Laranjinha, J., Almeida, L. and Madeira, V. (1995) Reduction of ferrylmyoglobin by dietary phenolic acids derivatives of cinnamic acid. Free Radical Biology and Medicine 19, 329-337.
Laranjinha, J., Vieira, O., Madeira, V. and Almeida, L. (1995) Two related phenolic antioxidants with opposite effects on vitamin E content in low density lipoproteins oxidized by ferrylmyoglobin: consumption vs regeneration. Archives of Biochemistry and Biophysics 323, 373-381.
Laranjinha, J., Vieira, O., Almeida, L. and Madeira, V. (1996) Inhibition of metmyoglobin/H2O2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids. Biochemical Pharmacology 51, 395-402.
Vieira, O., Laranjinha, J., Madeira, V., Almeida, L. (1996) A rapid two-step method to isolate low density lipoproteins free from water-soluble plasma antioxidants. Journal of Lipid Research 37, 2715-2721.
Vieira, O., I. Escargueil-Blank, Laranjinha, J., Almeida, L., Salvayre, R. and Nègre-Salvayre, A. (1998) Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL. British Journal of Pharmacology 123, 565-573.
Santos, A., Laranjinha, J. and Almeida, L. (1998) Tetrasulphonate aluminum phtalocyanine (AlPcS4) incorporates in human plasma lipoproteins: photoxidation of low density lipoproteins. Photochemistry and Photobiology 67 (4) 378-385.
Vieira, O., Laranjinha, J., Madeira, V. and Almeida, L. (1998) Cholesteryl ester hydroperoxide formation in myoglobin-catalyzed low density lipoprotein oxidation: concerted antioxidant activity of caffeic and p-coumaric acids with ascorbate. Biochemical Pharmacology 55, 333-340.
Laranjinha, J. and Cadenas, E. (1999) Redox cycles of caffeic acid, alfa-tocopherol, and ascorbate. Implications for LDL protection against oxidation. IUBMB Life 48, 1-9.
Serafini M, Laranjinha J, Almeida LM, Maiani G. (2000) Inhibition of human LDL lipid peroxidation by phenols rich beverages and their impact on plasma Total Antioxidant Capacity (TRAP) in humans. Journal of Nutritional Biochemistry 11, 585-590.
Laranjinha, J. (2001) Redox cycles of caffeic acid with alpha-tocopherol and ascorbate. Methods in Enzymology 335, 282-295.
Martins, J. Madeira, V., Almeida, L. and Laranjinha, J. (2002) Photoactivation of phthalocyanine-loaded low density lipoproteins induces a local oxidative stress that propagates to human erythrocytes. Protection by caffeic acid. Free Radical Research 36, 1-13.
Ledo A., Barbosa, R., Frade J. and Laranjinha, J. (2002) Nitric oxide monitoring in hippocampal brain slices using electrochemical methods. In: Methods in Enzymology 359, 111-125.
Laranjinha, J., Cadenas, E. (2002) Oxidation of DOPAC by nitric oxide. Effect of superoxide dismutase. Journal of Neurochemistry81, 892-900.
Silva Porto, P., Laranjinha, J., Freitas, V. (2003) Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships. Biochemical Pharmacology 66, 947-954.
Ana Ledo, João Frade, Rui M. Barbosa, João Laranjinha (2004) Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions. Molecular Aspects of Medicine 25, 75-89.
Martins J, Almeida L. and Laranjinha J. (2004) Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human low density lipoproteins. Implications for photodynamic therapy. Photochemistry & Photobiology 80, 267-273.
Estronca LM, Moreno MJ, Laranjinha JA, Almeida LM and Vaz WL (2005) Kinetics and thermodynamics of lipid amphiphile exchange between lipoproteins and albumin in serum Biophyical. Journal 88, 557-565.
Fernando Antunes, Carla Nunes, João Laranjinha and Enrique Cadenas (2005) Redox interactions of nitric oxide with dopamine and its derivatives. Toxicology 208, 207-212.
Frade J, Ferreira N., Barbosa R.M. and Laranjinha J. (2005) Molecular mechanisms of neuroprotection by natural antioxidant polyphenols. Current Medicinal Chemistry – Central Nervous Systems Agents 5, 307-318.
Nuno R. Ferreira, Ana Ledo, João G. Frade, Greg A. Gerhardt, João Laranjinha, Rui M. Barbosa (2005). Electrochemical measurement of endogenously-produced nitric oxide in brain slices using o-phenylenediamine-modified carbon fiber microelectrodesAnalytica Chimica Acta, 535, 1-7.
Teresa Sousa, Eduarda Fernandes, Carla Nunes, João Laranjinha, Félix Carvalho, Dora Pinho, Manuela Morato, António Albino-Teixeira (2005) Scavenging of nitric oxide by an antagonist of adenosine receptors. Journal of Pharmacy and Pharmacology, 57, 399-404.
Carla Nunes, Leonor Almeida and João Laranjinha (2005) Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson´s disease. Neurochemistry International. 47, 173-182.
Ana Ledo, Rui M. Barbosa, Greg A. Gerhardt, Enrique Cadenas, and João Laranjinha (2005) Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of the NMDA glutamate receptor. Proceedings of the National Academy of Sciences of the USA, 102, 17483-17488.
Frank J, Budek A, Lundh T, Parker RS, Swanson JE, Lourenco CF, Gago B, Laranjinha J, Vessby B, Kamal-Eldin A. (2006) Dietary flavonoids with a catechol structure increase alpha -tocopherol in rats and protect the vitamin from oxidation in vitro. Journal of Lipid Research, 47, 2718-25.
Ledo A., Frade JG, Barbosa RM and Laranjinha J. (2006) Regulation of nitric oxide dynamics in hippocampus by NMDA and AMPA glutamate receptors. Current Topics in Pharmacology. 10, 55-70.
Laranjinha, J. and Ledo, A (2007) Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria. Frontiers in Bioscience, 12, 1094-106.
Osorio NS, Carvalho A, Almeida AJ, Padilla-Lopez S, Leao C, Laranjinha J, Ludovico P, Pearce DA, Rodrigues F. (2007) Nitric Oxide Signaling Is Disrupted in the Yeast Model for Batten Disease. Mol. Biol. Cell 18, 2755-67.
Almeida B, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osorio NS, Kollau A, Mayer B, Leao C, Laranjinha J,Rodrigues F, Madeo F, Ludovico P. (2007) NO-mediated apoptosis in yeast. J Cell Sci. 120(Pt 18) 3279-88.
Bruno Gago, Jon O. Lundberg, Rui M. Barbosa and João Laranjinha (2007) Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radical Biology Medicine, 43, 1233-42.
Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J, Laranjinha J, Heales S. (2008) Glutamate Induces Release of Glutathione from Cultured Rat Astrocytes – A Possible Neuroprotective Mechanism? J. Neurochem. 105, 1144-1152.
Lourenço CF, Gago B, Barbosa RM, de Freitas V, Laranjinha J. (2008) LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion. J Agric Food Chem, 56, 3798-804.
Bruno Gago, Thomas Nyström, Carlos Cavaleiro, Bárbara S Rocha Rui Barbosa, João Laranjinha, Jon O Lundberg (2008) The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic Biol Med, 45, 404-412.
Rui M. Barbosa, Cátia F. Marques, Ricardo M. Santos, Francois Pomerleau, Peter Huettl, Greg A. Gerhardt and João Laranjinha (2008). In vivo real time measurement of endogenous nitric oxide in anesthetized rat brain. Methods in Enzymology, 441, 351-367.
Bem AF, Farina M, Portella RD, Nogueira CW, Dinis TC, Laranjinha JA, Almeida LM, Rocha JB. (2008) Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis, 201, 92-100.
Ricardo M. Santos, Cátia F. Lourenço, Ana P. Piedade, Rodney Andrews, François Pomerleau, Peter Huettl, Greg A. Gerhardt, João Laranjinha, Rui M. Barbosa (2008) A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue. Biosensors Bioelectronics, 24, 704-709.
Nunes C., Almeida L. and Laranjinha J. (2008) 3,4-dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning. Neurotoxicology 29, 998-1007.
Frade JG, Barbosa RM, Laranjinha J. (2009) Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices. Hippocampus, 19, 603-611.
Rocha, BS, Gago, B., Barbosa R.M. and Laranjinha J. (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology, 265, 41-48.
Rocha, BS, Gago, B., Barbosa R.M. and Laranjinha J (2010) Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: physiological impact. Nitric Oxide, 22, 235-241.
Ledo, A, Rui Barbosa, Enrique Cadenas, and João Laranjinha (2010) Dynamic and interaction profiles of NO and O2 in rat hippocampal slices. Free Radic Biol Med, 48, 1044-1050.
Lourenço CF, Santos R, Barbosa RM, Gerhardt G, Cadenas E and Laranjinha J. (2011) In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in hippocampus. Hippocampus, 21, 622-630.
Santos RM, Lourenço CF, Pormeleau F, Huettl P, Gerhardt GA, Laranjinha J and Barbosa RM (2011) Brain nitric oxide inactivation is governed by the vasculature. Antiox Redox Signal, 14, 1011-1021.
Rocha BS, Bruno Gago, Cassilda Pereira, Rui M Barbosa, Silvina Bartesaghi, Jon O Lundberg, Rafael Radi and João Laranjinha(2011) Dietary nitrite in nitric oxide biology: a redox interplay with implications for pathophysiology and therapeutics. Current Drug Targets 12, 1351-1363.
Santos RM, Lourenço CF, Gerhardt GA, Cadenas, E, Laranjinha J and Barbosa RM (2011) Evidence for a pathway that facilitates nitric oxide diffusion in the brain. Neurochem. Int. 59, 90-96.
Barbosa RM, Jesus AJ, Santos, RM, Pereira C, Lourenço CF, Rocha B, Ferreira NR, Ledo A and Laranjinha J (2011) Preparation, standardization and measurement of nitric oxide solution. Global Journal Analytical Chemistry 2, 272-284.
Nunes C, Almeida, L, Barbosa RM and Laranjinha J (2011) Nitric oxide and DOPAC-induced cell death: from GSH depletion to mitochondrial energy crisis. Mol. Cell. Neurosci. 48, 94-103.
Ledo A, Barbosa RM and Laranjinha J (2012) Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices. Methods Mol Biol 810, 73-88.
Rocha BS, Gago B, Barbosa RM, Lundberg JO, Radi R, Laranjinha J. (2012) Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling. Free Radic Biol Med. 52, 693-698.
Bretón-Romero R, González de Orduna C, Romero N, Sánchez-Gómez FJ, de Álvaro C, Porras A, Rodríguez-Pascual F, LaranjinhaJ, Radi R and Lamas S (2012) Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Free Radic Biol. Med. 52, 1093-1100.
Santos RM, Lourenço CF, Ledo A, Barbosa RM, Laranjinha J. (2012) Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration. Int J Cell Biol. 2012, 391914.
Laranjinha J, Santos RM, Lourenço CF, Ledo A and Barbosa RM (2012) Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling. Ann N Y Acad Sci 1259, 10-18.
https://doi.org/10.1111/j.1749-6632.2012.06582.x
Figueiras E, Oliveira R, Lourenço CF, Campos R, Humeau-Heurtier A, Barbosa RM, Laranjinha J, Requicha Ferreira LF, de Mul FF. (2013) Self-mixing microprobe for monitoring microvascular perfusion in rat brain. Med Biol. Eng. Comput. 51, 103-112.
Nunes C, Ferreira E, Freitas V, Almeida L, Barbosa RM, Laranjinha J. (2013) Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells. Food and Function 4, 373-383.
Rocha BS, Gago B, Barbosa RM, Lundberg JO, Mann GE, Radi R, Laranjinha J. (2013) Pepsin is nitrated in the rat stomach acquiring antiulcerogenic activity: a novel interaction between dietary nitrate and gut proteins. Free Radic. Biol. Med. 58, 26-34.
Santos RM, Rodrigues MS, Laranjinha J and Barbosa RM (2013) Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain. Biosensors and Bioelectronics 44, 152-159.
Oliveira SC, Santarino IB, Enache TA, Nunes C, Laranjinha J, Barbosa RM and Oliveira-Brett AM (2013) Human cólon adenocarcinoma HT-29 cell: electrochemistry and nicotine stimulation. Bioelectrochemistry 94c, 30-38.
Pereira C, Ferreira NR, Rocha BS, Barbosa RM, and Laranjinha J (2013) The redox interplay between nitrite and nitric oxide: from the gut to the brain. Redox Biol. 1, 276-284.
Ferreira NR, Santos RM, Laranjinha J and Barbosa RM (2013) Real time in vivo measurement of ascorbate in the brain using carbon nanotube-modified microelectrodes. Electroanalysis 25, 1757-1763.
Lourenço CF, Ferreira NR, Lukacova N, Barbosa RM and Laranjinha J. (2014) The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum. Brain Research 1554, 1-11.
Laranjinha J (2014) Nutrition and ageing: from phenomenological observations to molecular mechanisms. Commentary. Genes Nutr9, 407.
Lourenço CF, Santos RM, Barbosa RM, Cadenas E, Radi R and Laranjinha J. (2014) Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide. Free Radic Biol Med 73, 421-429.
Rocha BS, Nunes C, Pereira C, Barbosa RM, Laranjinha J (2014) A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate:nitrite:nitric oxide pathway in the gut. Food Funct. 5, 1646-52.
Ledo A, Lourenço CF, Caetano M, Barbosa RM and Laranjinha J (2015) Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats. Cell. Mol. Neurobiol. 35, 33-44.
Pereira C, Barbosa RM, Laranjinha J (2015) Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine. J Nutr Biochem 26, 476-483.
Rocha BS, Gago B, Barbosa RM, Cavaleiro C and Laranjinha J (2015) Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: potential impact on gastric motility. Free Radic Biol Med 82, 160-166.
Santos RM, Laranjinha J, Barbosa RM and Sirota A (2015) Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo using a novel choline oxidase based electrochemical biosensor. Biosens Bioelectron 69C, 83-94.
Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J. (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci. 27, 7-103.
Ferreira NR, Lourenço C, Barbosa RM and Laranjinha J (2015) Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: a novel functional interplay. Brain Res Bull 114, 13-19.
Nunes C, Teixeira N, Serra D, Freitas V, Almeida L, and João Laranjinha J (2016) Red wine polyphenol extract protect intestinal epithelial cells from inflammation via complementary modulation of JAK/STAT and Nrf2 pathways. Toxicology Research 5, 53-65.
Barbara S Rocha, Rui M Barbosa, Jon M Lundberg, Rafael Radi, and João Laranjinha (2016) Role of nitrite, urate and pepsin in the gastroprotective effects of saliva. Redox Biology 8, 407-414.
Dias C, Lourenço CM, Ferreiro E, Barbosa RM, Laranjinha J and Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer’s disease: implications for neurometabolic regulation. Neurobiol Aging 46, 84-95.
Rocha BS, Correia MG, Fernandes AC, Gonçalves JS and Laranjinha J (2016) Dietary nitrite induces occludin nitration in the stomach. Free Radical Research 50, 1257-1264.
Cátia F. Lourenço, Ana Ledo, João Laranjinha, Greg A. Gerhardt and Rui M. Barbosa (2016) Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain Sensors and Actuators B: Chemical 237, 298-307.
Rocha BS, Nunes C and Laranjinha J (2016) Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome. The International Journal of Biochemistry & Cell Biology, 81, 393-402.
Nunes C, Almeida L, Barbosa R and Laranjinha J (2017) Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation. Food and Function, 8, 387-396.
Ledo, Ana; Lourenço, Cátia; Laranjinha, João; Brett, Christopher; Gerhardt, Greg; Barbosa, Rui (2017) Ceramic-based Multi-Site Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue. Analytical Chemistry 89, 1674-1683.
Cátia F. Lourenço, Ana Ledo, Rui M. Barbosa and João Laranjinha (2017) Neurovascular uncoupling in the triple transgenic model of Alzheimer´s disease: impaired cerebral blood flow response to neuronal-derived nitric oxide signaling. Experimental Neurology 291, 36-43.
Cátia F. Lourenço, Ana Ledo, Rui M. Barbosa and João Laranjinha (2017) Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration. Free Radical Biology and Medicine 108, 668-682.
Egea J. et al (2017) European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology 13, 94-162.
Lourenço, Cátia; Ledo, Ana; Gerhardt, Greg; Laranjinha, João and Barbosa, Rui (2017) Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays. Scientific Reports 7, 6764 (1-12).
Ledo, Ana; Lourenço, Cátia; Laranjinha, João; Gerhardt, Greg; Barbosa, Rui (2017) Combined in vivo amperometric oximetry and electrophysiology in a single sensor – a tool for epilepsy research. Analytical Chemistry 89, 12383-12390.
Ferreira R. Nuno; Ledo, Ana; Laranjinha J; Gerhardt Greg and Barbosa, Rui (2018) Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays. Biolectrochemistry 121, 142-15.
Ledo, A. Lourenço, C. F. Laranjinha, J., Gerhardt, G. and Barbosa, R. M. (2018). Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry. Current Opinion in Electrochemistry 12, 129-140.
Dias C, Lourenço CM, Barbosa RM, Laranjinha J and Ledo A (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Analytical Biochemistry 551, 43-50.
Ledo A, Barbosa RM, Laranjinha J (2018) Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices. Methods Mol Biol 1782, 89-107.
Lourenço CM, Ledo A, Caetano M, Barbosa RM, Laranjinha J (2018) Age-dependent impairment of neurovascular and neurometabolic coupling in the hippocampus. Frontiers in Physiology 9, 913.
Carla Nunes, Víctor de Freitas, Leonor Almeida and João Laranjinha (2019) Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation. Food & Function 10, 1364-1374.
Rocha, BS, Correia MG, Pereira A, Henriques, I, Da Silva GJ, Laranjinha J (2019) Inorganic nitrate prevents the loss of tight junction proteins and modulates inflammatory events induced by broad-spectrum antibiotics: a role for intestinal microbiota. Nitric Oxide, 88, 27-34.
Ledo, A., Rocha, B., Laranjinha, J. (2019) Bioactive lipids and the gut-brain-axis: diet as a modulator of bioactivity and diversity of lipids in the brain. Adv. Exp. Med. Biol. 1127, 147-168.
Nunes, Carla; Figueiredo, Rui; Laranjinha, João and Silva, Gabriela (2019) Intestinal cytotoxicity induced by Escheria coli is fully prevented by red wine polyphenol extract: mechanistic insights in epithelial cells. Chemico-Biological Interactions, 310, 108711.
Rocha, B. and Laranjinha, J. (2020) Nitrate from diet might fuel gut microbiota metabolism: minding the gap between redox signaling and inter-kingdom communication. Free Radic. Biol. Med. 149, 37-43.
Laranjinha J, Nunes C, Ledo A, Lourenço C and Barbosa RM (2021) The peculiar facets of nitric oxide as a cellular messenger: from disease-associated signaling to the regulation of brain bioenergetics and neurovascular coupling. Neurochem. Res. 46, 64-76.
Ledo, Ana; Lourenço, Cátia F; Cadenas, E; Barbosa, R; Laranjinha, J. (2021) The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: switching signaling to degeneration. Free Radical Biology & Medicine, 2021, 162, 500-513.
Nunes, C and Laranjinha, J. (2021) Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson’s disease.
Archives of Biochemistry and Biophysics. 704, 108877.
Mancini G, Dias C, Lourenço CF, Laranjinha J, de Bem A and Ledo, A (2021) A high fat/cholesterol diet recapitulates some Alzheimer's disease-like features in mice: focus on hippocampal mitochondrial dysfunction. Journal of Alzheimer´s Disease 82, 1619-1633.
Lourenço, CF and Laranjinha, J. (2021) Nitric oxide pathways in neurovascular coupling under normal and stress conditions in the brain: strategies to rescue aberrant coupling and improve cerebral blood flow. Frontiers in Physiology 12, 729201.
Rodrigues MS, Ferreira C, Dias C, Pliássova A, Souza L, Ledo A, Laranjinha J, Cunha RA and Kofalvi A (2022) An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease. European Journal of Neuroscience 55, 1051-62.
doi: 10.1111/ejn.14944
Ledo A, Fernandes E, Salvador A, Laranjinha J and Barbosa R (2022) In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity. Redox Biology 50, 1-9.
DOI: 10.1016/j.redox.2022.102250
Dias, C., Lourenço, CF., Laranjinha, J. Ledo, A. (2022) Modulation of Oxidative Neurometabolism in Ischemia/Reperfusion by Nitrite. Free Radical Biol Med. 193, 779-786.
doi: 10.1016/j.freeradbiomed.2022.11.021
Gonçalves J, Raquel Seiça, Laranjinha J and Lourenço CM (2022) Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats. Free Radical Biol Med.193, 669-675.
doi: 10.1016/j.freeradbiomed.2022.11.009
Fraga CG, Trostchansky A, Rocha BS, Laranjinha J, Rubbo H and Galleano M (2023) (Poly)phenols and nitrolipids: relevant participants in nitric oxide metabolism. Mol. Aspects Med. 89, 101158.
doi: 10.1016/j.mam.2022.101158
Reva K, Laranjinha J and Rocha B (2023) Epigenetic modifications induced by the gut microbiota may result from what we eat: should we talk about Precision Diet in health and disease? Metabolites 13, 375.
https://doi.org/10.3390/metabo13030375
Dias C, Fernandes, e, Barbosa RM, Laranjinha J and Ledo A (2023) Astrocytic Aerobic Glycolysis Provides Lactate to Support Neuronal Oxidative Metabolism in the Hippocampus. Biofactors 49, 875-886.
DOI: 10.1002/biof.1951
Nunes C and Laranjinha J (2023) Nitric oxide production from nitrite plus ascorbate during ischemia upon hippocampal glutamate NMDA receptor stimulation. BioChem 3, 78-90.
https://doi.org/10.3390/biochem3020006
Reis A, Rocha BS, Laranjinha J and de Freitas V (2024) Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on NO bioavailability in hypertension. FEBS Lett. (in press).
https://doi.org/10.1002/1873-3468.14812
Gonçalves JS, Marçal AL, Marques BS, Costa FD, Laranjinha J, Rocha BS, Lourenço CF (2024) Dietary nitrate supplementation and cognitive health: the nitric oxide-dependent neurovascular coupling hypothesis. Biochem. Soc. Trans. (in press).
doi: 10.1042/BST20230491
Paiva B, Laranjinha J and Rocha BS (2024) Do oral and gut microbiota communicate through redox pathways? A novel asset of the nitrate-nitrite-NO pathway. FEBS Lett. (in press).
DOI: https://doi.org/10.1002/1873-3468.14859
Faculdade de Farmácia, Universidade de Coimbra
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