Neurociências e Doença

Biologia da Sinapse

Sinapses Exciatórias

Plasticidade Sináptica

Memória

Disfunção Sináptica

Doenças Neuropsiquiátricas.

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Líder

Ana Luisa Carvalho

Investigador(a)

Visão Geral

As memórias, os pensamentos e o comportamento estão codificados em alterações na eficiência da comunicação sináptica. Estas alterações constituem a base celular e molecular da formação de memórias. No entanto, as alterações funcionais usadas pelas sinapses para codificar e processar informação são ainda pouco conhecidas. O nosso grupo está interessado em compreender os mecanismos moleculares subjacentes à função e plasticidade sinápticas, e em estudar de que forma a disfunção sináptica está na base das doenças neuropsiquiátricas e neurodegenerativas.

Usamos uma combinação de metodologias, como culturas primárias de neurónios e fatias de cérebro, modelos animais geneticamente modificados, bioquímica, biologia celular e molecular, electrofisiologia e análise de comportamento animal, com o objetivo de estudar a papel de moléculas e processos neuromoduladores que regulam os receptores para neurotransmissores e a fisiologia sináptica.

Esta investigação de processos fundamentais tem implicações para a compreensão de doenças neuropsiquiátricas, já que existe associação forte entre variantes genéticas de várias proteínas sinápticas e doenças como o défice intelectual, a esquizofrenia e o autismo. Focamo-nos em alterações na função sináptica relacionadas com doença, alterações genéticas, desencadeadas pela experiência, ou produzidas por anticorpos produzidos por indivíduos com encefalite autoimune sináptica. Os nossos estudos celulares e moleculares e os modelos animais que geramos no laboratório podem contribuir para o desenvolvimento racional de terapias para estas doenças.

Artigos em Destaque

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al, 2019. Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. https://doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al, 2019. Cerebral Cortex. 2019. https://doi.org/10.1093/cercor/bhz032 . 10.1093/cercor/bhz032 . Cerebral Cortex

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., 2016. Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

New insights on synaptic dysfunction in neuropsychiatric disorders

Lima Caldeira, G.; Peça, J.; Carvalho, A.L., 2019. Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses

Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al, 2018. Neuron. 106 - 119.e7. 1. 100. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS . 10.1016/j.neuron.2018.09.012 . Neuron


Publicações

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al, 2022. Molecular Psychiatry. 2022. http://dx.doi.org/10.1038/s41380-022-01487-w . 10.1038/s41380-022-01487-w . Molecular Psychiatry

Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, 2021. Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . Science Signaling

It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Ana Luisa Carvalho; Dominique Fernandes, 2021. PLOS Biology. 2021. https://doi.org/10.1371/journal.pbio.3001448 . 10.1371/journal.pbio.3001448 . PLOS Biology

Interplay between NMDA receptor dynamics and the synaptic proteasome

Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc, 2021. European Journal of Neuroscience. 6000 - 6011. 6. 54. 2021. https://doi.org/10.1111/ejn.15427 . 10.1111/ejn.15427 . European Journal of Neuroscience

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al, 2019. Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al, 2019. Cerebral Cortex. 2019. https://doi.org/10.1093/cercor/bhz032 . 10.1093/cercor/bhz032 . Cerebral Cortex

The role of ghrelin in regulating synaptic function and plasticity of feeding-associated circuits

Serrenho, D.; Santos, S.D.; Carvalho, A.L., 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068476880&partnerID=MN8TOARS . 10.3389/fncel.2019.00205 . Frontiers in Cellular Neuroscience

New insights on synaptic dysfunction in neuropsychiatric disorders

Lima Caldeira, G.; Peça, J.; Carvalho, A.L., 2019. Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al, 2019. Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. https://doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Morató, X.; Luján, R.; Gonçalves, N.; Watanabe, M.; Altafaj, X.; Carvalho, A.L.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., 2018. Human Molecular Genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . Human Molecular Genetics

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses

Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al, 2018. Neuron. 106 - 119.e7. 1. 100. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS . 10.1016/j.neuron.2018.09.012 . Neuron

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses

Louros, S.R.; Caldeira, G.L.; Carvalho, A.L., 2018. Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054810796&partnerID=MN8TOARS . 10.3389/fnmol.2018.00328 . Frontiers in Molecular Neuroscience

Mechanisms of homeostatic plasticity in the excitatory synapse

Dominique Fernandes; Ana Luísa Carvalho, 2016. Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13687 . 10.1111/jnc.13687 . Journal of Neurochemistry

7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’

Carlos B. Duarte; Ana Luisa Carvalho, 2016. Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13839 . 10.1111/jnc.13839 . Journal of Neurochemistry

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, 2016. Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., 2016. Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons

Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos, 2016. BIO-PROTOCOL. 10. 6. 2016. http://dx.doi.org/10.21769/bioprotoc.1807 . 10.21769/bioprotoc.1807 . BIO-PROTOCOL

SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97

Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al, 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1950 - 1959. 9. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.06.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome

Ferreira, J.S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K.W.; Smit, A.B.; Craig, A.M.; Carvalho, A.L., 2015. Journal of Neuroscience. 8462 - 8479. 22. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930427217&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3567-14.2015 . Journal of Neuroscience

Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., 2015. Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L., 2014. Proceedings of the National Academy of Sciences of the United States of America. 1. 111. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS . 10.1073/pnas.1313798111 . Proceedings of the National Academy of Sciences of the United States of America

Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., 2014. Molecular Vision. 894 - 907. 20. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903118075&partnerID=MN8TOARS . Molecular Vision

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, 2014. Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

A role for stargazin in experience-dependent plasticity

Louros, S.; Hooks, B.; Litvina, L.; Carvalho, A.; Chen, C., 2014. Cell Reports. 1614 - 1625. 5. 7. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902344846&partnerID=MN8TOARS . 10.1016/j.celrep.2014.04.054 . Cell Reports

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway

Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., 2014. Experimental Neurology. 698 - 709. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.07.023 . Experimental Neurology

Regulation of synapse composition by protein acetylation: The role of acetylated cortactin

Catarino, T.; Ribeiro, L.; Santos, S.D.; Carvalho, A.L., 2013. Journal of Cell Science. 149 - 162. 1. 126. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875621271&partnerID=MN8TOARS . 10.1242/jcs.110742 . Journal of Cell Science

Glutamate Binding to the GluN2B Subunit Controls Surface Trafficking of N-Methyl-D-aspartate (NMDA) Receptors

She, Kevin; Ferreira, Joana S.; Carvalho, Ana Luisa; Craig, Ann Marie, 2012. Journal of Biological Chemistry. 27432 - 27445. 33. 287. 2012. 10.1074/jbc.M112.345108 . Journal of Biological Chemistry

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., 2012. Neuroscience. 23 - 32. 219. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors

Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L., 2012. Journal of Biological Chemistry. 6868 - 6877. 9. 287. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS . 10.1074/jbc.M111.322909 . Journal of Biological Chemistry

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, 2011. Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease

Matos, C.A.; de Macedo-Ribeiro, S.; Carvalho, A.L., 2011. Progress in Neurobiology. 26 - 48. 1. 95. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960668226&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.06.007 . Progress in Neurobiology

Activity and protein kinase C regulate synaptic accumulation of N-Methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant

Ferreira, J.S.; Rooyakkers, A.; She, K.; Ribeiro, L.; Carvalho, A.L.; Craig, A.M., 2011. Journal of Biological Chemistry. 28331 - 28342. 32. 286. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051515440&partnerID=MN8TOARS . 10.1074/jbc.M111.222539 . Journal of Biological Chemistry

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2010. Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Leptin regulates AMPA receptor trafficking via PTEN inhibition

Moult, P.R.; Cross, A.; Santos, S.D.; Carvalho, A.-L.; Lindsay, Y.; Connolly, C.N.; Irving, A.J.; Leslie, N.R.; Harvey, J., 2010. Journal of Neuroscience. 4088 - 4101. 11. 30. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949725839&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3614-09.2010 . Journal of Neuroscience

Nucleocytoplasmic shuttling activity of ataxin-3

Macedo-Ribeiro, S.; Cortes, L.; Maciel, P.; Carvalho, A.L., 2009. PLoS ONE. 6. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149129949&partnerID=MN8TOARS . 10.1371/journal.pone.0005834 . PLoS ONE

Regulation of AMPA receptors and synaptic plasticity

Santos, S.D.; Carvalho, A.L.; Caldeira, M.V.; Duarte, C.B., 2009. Neuroscience. 105 - 125. 1. 158. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149467917&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.02.037 . Neuroscience

Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors

Gomes, A.R.; Ferreira, J.S.; Paternain, A.V.; Lerma, J.; Duarte, C.B.; Carvalho, A.L., 2008. Molecular and Cellular Neuroscience. 323 - 334. 2. 37. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749131588&partnerID=MN8TOARS . 10.1016/j.mcn.2007.10.008 . Molecular and Cellular Neuroscience

Role of the brain-derived neurotrophic factor at glutamatergic synapses

Carvalho, A.L.; Caldeira, M.V.; Santos, S.D.; Duarte, C.B., 2008. British Journal of Pharmacology. SUPPL. 1. 153. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349114504&partnerID=MN8TOARS . 10.1038/sj.bjp.0707509 . British Journal of Pharmacology

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Alves, S.; Régulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A.L.; et al, 2008. Human Molecular Genetics. 2071 - 2083. 14. 17. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249122383&partnerID=MN8TOARS . 10.1093/hmg/ddn106 . Human Molecular Genetics

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection

Nunes-Correia, I.; Rodríguez, J.M.; Eulálio, A.; Carvalho, A.L.; Citovsky, V.; Simões, S.; Faro, C.; Salas, M.L.; Pedroso de Lima, M.C., 2008. Veterinary Microbiology. 47 - 59. 1-2. 130. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549086170&partnerID=MN8TOARS . 10.1016/j.vetmic.2007.12.010 . Veterinary Microbiology

PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression

Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L., 2007. Traffic. 259 - 269. 3. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS . 10.1111/j.1600-0854.2006.00521.x . Traffic

Erratum: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons (Journal of Biological Chemistry (2007) 282, (12619-12628))

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 37. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848900818&partnerID=MN8TOARS . Journal of Biological Chemistry

BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.F.; Carvalho, A.L.; Duarte, C.B., 2007. Molecular and Cellular Neuroscience. 208 - 219. 2. 35. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249712975&partnerID=MN8TOARS . 10.1016/j.mcn.2007.02.019 . Molecular and Cellular Neuroscience

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 12619 - 12628. 17. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250329980&partnerID=MN8TOARS . 10.1074/jbc.M700607200 . Journal of Biological Chemistry

NEDD8: A new ataxin-3 interactor

Ferro, A.; Carvalho, A.L.; Teixeira-Castro, A.; Almeida, C.; Tomé, R.J.; Cortes, L.; Rodrigues, A.-J.; et al, 2007. Biochimica et Biophysica Acta - Molecular Cell Research. 1619 - 1627. 11. 1773. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548938484&partnerID=MN8TOARS . 10.1016/j.bbamcr.2007.07.012 . Biochimica et Biophysica Acta - Molecular Cell Research

Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides

Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P., 2006. Journal of Allergy and Clinical Immunology. 878 - 884. 4. 118. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS . 10.1016/j.jaci.2006.05.029 . Journal of Allergy and Clinical Immunology

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., 2006. Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C., 2006. Journal of Virology. 1393 - 1404. 3. 80. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS . 10.1128/JVI.80.3.1393-1404.2006 . Journal of Virology

Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression

Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B., 2004. Journal of Neurochemistry. 673 - 682. 3. 90. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02519.x . Journal of Neurochemistry

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P., 2004. Journal of Virology. 9731 - 9739. 18. 78. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS . 10.1128/JVI.78.18.9731-9739.2004 . Journal of Virology

Downregulation of retinal GLUT1 in diabetes by ubiquitinylation

Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C., 2004. Molecular Vision. 618 - 628. 10. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-16544391719&partnerID=MN8TOARS . Molecular Vision

Regulation of AMPA receptor activity, synaptic targeting and recycling: Role in synaptic plasticity

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Protein kinase C¿ associates directly with the GluR4 a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit: Effect on receptor phosphorylation

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Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons

Carvalho, A.L.; Correia, S.; Faro, C.J.; Duarte, C.B.; Carvalho, A.P.; Pires, E.M.V., 2002. European Journal of Neuroscience. 465 - 474. 3. 15. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036456320&partnerID=MN8TOARS . 10.1046/j.0953-816x.2001.01881.x . European Journal of Neuroscience

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons

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Regulation of AMPA Receptors by Phosphorylation

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Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors

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Photoacoustic measurements of porphyrin triplet-state quantum yields and singlet-oxygen efficiencies

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Glutamate in life and death of retinal amacrine cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Carvalho, A.L.; Agostinho, P.M.; Carvalho, A.P., 1998. General Pharmacology. 289 - 295. 3. 30. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032033584&partnerID=MN8TOARS . 10.1016/S0306-3623(97)00360-1 . General Pharmacology

Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells

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Differential acetylcholine and GABA release from cultured chick retina cells

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In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent

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