Terapias Inovadoras

Nanossistemas e Estratégias Antitumorais Direcionadas

Nanossistemas

Entrega de Material Genético

Entrega de Fármacos

Terapia do Cancro Direcionada

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Líder

Henrique Faneca

Investigador(a)


Linhas de interesse

Desenvolvimento e caracterização de novos nanossistemas de base inorgânica, lipídica e polimérica que tenham a capacidade de entregar diferentes moléculas terapêuticas, como material genético e fármacos, de forma específica e eficiente às células alvo

Geração de estratégias antitumorais multialvo combinadas, que atuem em várias vias de sinalização da carcinogénese

avaliação da atividade antitumoral, in vitro e in vivo, das estratégias individuais e das combinadas

e esclarecimento dos mecanismos envolvidos na morte das células tumorais

Visão Geral

O cancro continua a ser um dos maiores problema de saúde, sendo uma das principais causas de morte em todo o mundo. Apesar dos esforços que têm sido realizados, as opções de tratamento atuais são manifestamente insuficientes, estando associadas a múltiplas limitações. Estes factos evidenciam a necessidade urgente de desenvolver novas intervenções terapêuticas.

Os nanossistemas podem contribuir grandemente para o sucesso de novas estratégias antitumorais, uma vez que têm, nomeadamente os nanossistemas direcionados, a capacidade de entregar de forma específica e eficiente as moléculas terapêuticas às células alvo.

O propósito fundamental do nosso grupo é desenvolver novos nanossistemas que tenham a capacidade de mediar novas estratégias antitumorais multi-alvo, envolvendo por exemplo a combinação de terapia génica e quimioterapia, por forma a obter uma maior eficácia terapêutica que as atuais opções de tratamento.

Os nossos principais objetivos são:

  • Desenvolver e caracterizar diferentes nanossistemas de transporte e entrega de moléculas terapêuticas (em termos de: tamanho médio; carga superficial; morfologia; complexação e proteção de material genético; carregamento e libertação de fármacos; biocompatibilidade; interação e libertação nas células alvo).
  • Gerar e avaliar estratégias antitumorais multialvo (em termos de: viabilidade celular; proliferação; migração; níveis de apoptose e necrose; ciclo celular; níveis de ARNm e proteína dos alvos moleculares; histologia e tamanho dos tumores; sobrevivência dos animais) que atuem em várias vias de sinalização da carcinogénese.
  • Demonstrar que os nanossistemas e as estratégias antitumorais inovadoras geradas podem resultar numa maior eficiência terapêutica e menos efeitos secundários do que as terapias convencionais.

Publicações

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Informação sobre artigos em revista, actualizada a 17-12-2023, a partir da plataforma CIÊNCIAVITAE.

Targeted downregulation of MYC mediated by a highly efficient lactobionic acid-based glycoplex to enhance chemosensitivity in human hepatocellular carcinoma cells

Santo, Daniela; Mendonça, Patrícia V.; Serra, Arménio C.; Coelho, Jorge F.J.; Faneca, Henrique, 2023. International Journal of Pharmaceutics. 122865 - 122882. 637. 2023. http://dx.doi.org/10.1016/j.ijpharm.2023.122865 . 10.1016/j.ijpharm.2023.122865 . International Journal of Pharmaceutics

Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel

Santo, Daniela; Cordeiro, Rosemeyre A.; Mendonça, Patrícia V.; Serra, Arménio C.; Coelho, Jorge F. J.; Faneca, Henrique, 2023. Biomacromolecules. 1274 - 1286. 3. 24. 2023. http://dx.doi.org/10.1021/acs.biomac.2c01329 . 10.1021/acs.biomac.2c01329 . Biomacromolecules

Polymer- and lipid-based gene delivery technology for CAR T cell therapy

Pinto, Inês S.; Cordeiro, Rosemeyre A.; Faneca, Henrique, 2023. Journal of Controlled Release. 196 - 215. 353. 2023. http://dx.doi.org/10.1016/j.jconrel.2022.11.038 . 10.1016/j.jconrel.2022.11.038 . published Journal of Controlled Release

Expanding the use of affordable CuSO4·5H2O in ATRP techniques in homogeneous media

Ribeiro, Jessica P.M.; Mendonça, Patrícia V.; Santo, Daniela; De Bon, Francesco; Faneca, Henrique; Guliashvili, Tamaz; Coelho, Jorge F.J.; Serra, Arménio C., 2022. Polymer. 124526 - 124534. 241. 2022. http://dx.doi.org/10.1016/j.polymer.2022.124526 . 10.1016/j.polymer.2022.124526 . Polymer

Engineering silica-polymer hybrid nanosystems for dual drug and gene delivery

Cordeiro, Rosemeyre A.; Mendonça, Patrícia V.; Coelho, Jorge; Faneca, Henrique, 2022. Biomaterials Advances. 212742 - 212754. 135. 2022. http://dx.doi.org/10.1016/j.bioadv.2022.212742 . 10.1016/j.bioadv.2022.212742 . Biomaterials Advances

Fabrication of 3D scaffolds based on fully biobased unsaturated polyester resins by microstereo-lithography

Gonçalves, Filipa A M M; Fonseca, Ana C; Cordeiro, Rosemeyre; Piedade, Ana P; Faneca, Henrique; Serra, Arménio; Coelho, Jorge F J, 2022. Biomedical Materials. 025010 - 025021. 2. 17. 2022. http://dx.doi.org/10.1088/1748-605x/ac4b46 . 10.1088/1748-605x/ac4b46 . published Biomedical Materials

Stem cell membrane-coated abiotic nanomaterials for biomedical applications

Ferreira-Faria, Inês; Yousefiasl, Satar; Macário-Soares, Ana; Pereira-Silva, Miguel; Peixoto, Diana; Zafar, Hajra; Raza, Faisal; et al, 2022. Journal of Controlled Release. 174 - 197. 351. 2022. http://dx.doi.org/10.1016/j.jconrel.2022.09.012 . 10.1016/j.jconrel.2022.09.012 . published Journal of Controlled Release

Novel Non-Viral Vectors Based on Pluronic® F68PEI with Application in Oncology Field

Silva, Inês; Domingues, Cátia; Jarak, Ivana; Carvalho, Rui A.; Cordeiro, Rosemeyre A.; Dourado, Marília; Veiga, Francisco; Faneca, Henrique; Figueiras, Ana, 2022. Polymers. 5315 - 5329. 23. 14. 2022. http://dx.doi.org/10.3390/polym14235315 . 10.3390/polym14235315 . published Polymers

Triantennary GalNAc-Functionalized Multi-Responsive Mesoporous Silica Nanoparticles for Drug Delivery Targeted at Asialoglycoprotein Receptor

Cordeiro, Rosemeyre; Carvalho, Ana; Durães, Luísa; Faneca, Henrique, 2022. International Journal of Molecular Sciences. 6243 - 6260. 11. 23. 2022. http://dx.doi.org/10.3390/ijms23116243 . 10.3390/ijms23116243 . International Journal of Molecular Sciences

Combining gene therapy with other therapeutic strategies and imaging agents for cancer theranostics

Azevedo, Alexandro; Farinha, Dina; Geraldes, Carlos; Faneca, Henrique (4E1F-D234-7CD6), 2021. International Journal of Pharmaceutics. 120905 - 120928. 606. 2021. http://dx.doi.org/10.1016/j.ijpharm.2021.120905 . 10.1016/j.ijpharm.2021.120905 . published International Journal of Pharmaceutics

Non-Viral Gene Delivery Systems

Faneca, Henrique, 2021. Pharmaceutics. 446 - 449. 04. 13. 2021. https://doi.org/10.3390/ pharmaceutics13040446 . 10.3390/pharmaceutics13040446 . published Pharmaceutics

Recent advances in peptide-targeted micelleplexes: Current developments and future perspectives

Costa, Diana; Santo, Daniela; Domingues, Cátia; Veiga, Francisco; Faneca, Henrique (4E1F-D234-7CD6); Figueiras, Ana, 2021. International Journal of Pharmaceutics. 120362 - 120382. 597. 2021. https://doi.org/10.1016/j.ijpharm.2021.120362 . 10.1016/j.ijpharm.2021.120362 . published International Journal of Pharmaceutics

A Combined Antitumor Strategy Mediated by a New Targeted Nanosystem to Hepatocellular Carcinoma

Farinha, Dina; Michael Migawa; Sarmento-Ribeiro, AB; Faneca, Henrique, 2021. International Journal of Nanomedicine. 3385 - 3405. 16. 2021. https://doi.org/10.2147/IJN.S302288 . 10.2147/IJN.S302288 . published International Journal of Nanomedicine

Supercritically dried superparamagnetic mesoporous silica nanoparticles for cancer theranostics

Vaz-Ramos, Joana; Cordeiro, Rosemeyre; Castro, M. Margarida C.A.; Geraldes, Carlos F.G.C.; Costa, Benilde F.O.; Faneca, Henrique (4E1F-D234-7CD6); Durães, Luísa, 2020. Materials Science and Engineering: C. 111124 - 111138. 115. 2020. http://dx.doi.org/10.1016/j.msec.2020.111124 . 10.1016/j.msec.2020.111124 . published Materials Science and Engineering: C

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Carvalho, Ana Maria; Cordeiro, Rosemeyre A.; Faneca, Henrique (4E1F-D234-7CD6), 2020. Pharmaceutics. 649 - 694. 7. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12070649 . 10.3390/pharmaceutics12070649 . published Pharmaceutics

Polymeric nanoengineered HBsAg DNA vaccine designed in combination with ß-glucan

Edna Soares; Rosemeyre Cordeiro; Henrique Faneca; Olga Borges, 2019. International Journal of Biological Macromolecules. 930 - 939. 122. 2019. https://doi.org/10.1016/j.ijbiomac.2018.11.024 . 10.1016/j.ijbiomac.2018.11.024 . published International Journal of Biological Macromolecules

Poly(ethylene glycol)-block-poly(2-aminoethyl methacrylate hydrochloride)-based polyplexes as serum-tolerant nanosystems for enhanced gene delivery

Daniela Santo; Patrícia V. Mendonça; Mafalda S. Lima; Rosemeyre A. Cordeiro; Luis Cabanas; Arménio Serra; Jorge F.J. Coelho; Faneca, Henrique (4E1F-D234-7CD6), 2019. Molecular Pharmaceutics. 2129 - 2141. 5. 16. 2019. https://doi.org/10.1021/acs.molpharmaceut.9b00101 . 10.1021/acs.molpharmaceut.9b00101 . published Molecular Pharmaceutics

Replacing di(2-ethylhexyl) terephthalate by di(2-ethylhexyl) 2,5-furandicarboxylate for PVC plasticization: synthesis, materials preparation and characterization

Marina Matos; Rosemeyre A. Cordeiro; Faneca, Henrique; Jorge Coelho; Armando Silvestre; Andreia Sousa, 2019. Materials. 14. 12. 2019. http://dx.doi.org/10.3390/ma12142336 . 10.3390/ma12142336 . published Materials

Poly(ß-amino ester)-based gene delivery systems: From discovery to therapeutic applications

Rosemeyre A. Cordeiro; Arménio Serra; Jorge F.J. Coelho; Faneca, Henrique (4E1F-D234-7CD6), 2019. Journal of Controlled Release. 155 - 187. 310. 2019. https://doi.org/10.1016/j.jconrel.2019.08.024 . 10.1016/j.jconrel.2019.08.024 . published Journal of Controlled Release

High transfection efficiency promoted by tailor-made cationic tri-block copolymer-based nanoparticles

Cordeiro, R.A.; Santo, D.; Farinha, D.; Serra, A.; Faneca, Henrique (4E1F-D234-7CD6); Coelho, J.F.J., 2017. Acta Biomaterialia. 113 - 123. 47. 2017. https://doi.org/10.1016/j.actbio.2016.10.015 . 10.1016/j.actbio.2016.10.015 . published Acta Biomaterialia

Combination of poly[(2-dimethylamino)ethyl methacrylate] and poly(ß-amino ester) results in a strong and synergistic transfection activity

Santo, D.; Cordeiro, R.A.; Sousa, A.; Serra, A.; Coelho, J.F.J.; Faneca, Henrique (4E1F-D234-7CD6), 2017. Biomacromolecules. 3331 - 3342. 10. 18. 2017. https://doi.org/10.1021/acs.biomac.7b00983 . 10.1021/acs.biomac.7b00983 . published Biomacromolecules

Managing pancreatic adenocarcinoma: A special focus in microRNA gene therapy

Passadouro, M.; Faneca, Henrique (4E1F-D234-7CD6), 2016. International Journal of Molecular Sciences. 5. 17. 2016. https://doi.org/10.3390/ijms17050718 . 10.3390/ijms17050718 . published International Journal of Molecular Sciences

Intranasal administration of novel chitosan nanoparticle/DNA complexes induces antibody response to hepatitis B surface antigen in mice

Lebre, F.; Borchard, G.; Faneca, Henrique (4E1F-D234-7CD6); Pedroso De Lima, M.C.; Borges, O., 2016. Molecular Pharmaceutics. 472 - 482. 2. 13. 2016. https://doi.org/10.1021/acs.molpharmaceut.5b00707 . 10.1021/acs.molpharmaceut.5b00707 . published Molecular Pharmaceutics

Novel cationic triblock copolymer of poly[2-(dimethylamino)ethyl methacrylate]-block-poly(ß-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: A promising non-viral gene delivery system

Cordeiro, R.A.; Farinha, D.; Rocha, N.; Serra, A.C.; Faneca, Henrique (4E1F-D234-7CD6); Coelho, J.F.J., 2015. Macromolecular Bioscience. 215 - 228. 2. 15. 2015. https://doi.org/10.1002/mabi.201400424 . 10.1002/mabi.201400424 . published Macromolecular Bioscience

Shutting down the furnace: preferential killing of cancer cells with mitochondrial-targeting molecules

Deus, C.M.; Santos, G.L.; Loureiro, R.; Vega-Naredo, I.; Faneca, H.; Oliveira, P.J., 2015. Current Medicinal Chemistry. 2438 - 2457. 20. 22. 2015. http://www.eurekaselect.com/128348/article . 10.2174/0929867322666150209155957 . published Current Medicinal Chemistry

MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer

Passadouro, M.; Pedroso de Lima, M.C.; Faneca, Henrique (4E1F-D234-7CD6), 2014. International Journal of Nanomedicine. 3203 - 3217. 1. 9. 2014. https://www.dovepress.com/microrna-modulation-combined-with-sunitinib-as-a-novel-therapeutic-str-peer-reviewed-article-IJN . 10.2147/IJN.S64456 . published International Journal of Nanomedicine

Increased gene delivery efficiency and specificity of a lipid-based nanosystem incorporating a glycolipid

Magalhães, M.; Farinha, D.; Pedroso de Lima, M.C.; Faneca, Henrique (4E1F-D234-7CD6), 2014. International journal of nanomedicine. 4979 - 4989. 9. 2014. https://www.dovepress.com/increased-gene-delivery-efficiency-and-specificity-of-a-lipid-based-na-peer-reviewed-article-IJN . 10.2147/IJN.S69822 . published International journal of nanomedicine

Specific and efficient gene delivery mediated by an asialofetuin-associated nanosystem

Farinha, D.; Pedroso De Lima, M.C.; Faneca, Henrique (4E1F-D234-7CD6), 2014. International Journal of Pharmaceutics. 366 - 374. 1-2. 473. 2014. https://doi.org/10.1016/j.ijpharm.2014.07.019 . 10.1016/j.ijpharm.2014.07.019 . published International Journal of Pharmaceutics

3D printing of new biobased unsaturated polyesters by microstereo-thermallithography

Gonçalves, F.A.; Costa, C.S.; Fabela, I.G.; Farinha, D.; Faneca, H.; Simões, P.N.; Serra, A.C.; Bártolo, P.J.; Coelho, J.F., 2014. Biofabrication. 3. 6. 2014. https://iopscience.iop.org/article/10.1088/1758-5082/6/3/035024 . 10.1088/1758-5082/6/3/035024 . published Biofabrication

Suicide gene therapy in cancer: Where do we stand now?

Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V., 2012. Cancer Letters. 160 - 170. 2. 324. 2012. https://doi.org/10.1016/j.canlet.2012.05.023 . 10.1016/j.canlet.2012.05.023 . published Cancer Letters

Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents

Pinho, S.L.C.; Faneca, H.; Geraldes, C.F.G.C.; Delville, M.-H.; Carlos, L.D.; Rocha, J., 2012. Biomaterials. 925 - 935. 3. 33. 2012. https://doi.org/10.1016/j.biomaterials.2011.09.086 . 10.1016/j.biomaterials.2011.09.086 . published Biomaterials

Silica nanoparticles for bimodal MRI-optical imaging by grafting Gd3+ and Eu3+/Tb3+ complexes

Pinho, S.L.C.; Faneca, H.; Geraldes, C.F.G.C.; Rocha, J.; Carlos, L.D.; Delville, M.-H., 2012. European Journal of Inorganic Chemistry. 2828 - 2837. 16. 2012. https://doi.org/10.1002/ejic.201101110 . 10.1002/ejic.201101110 . published European Journal of Inorganic Chemistry

Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo

Duarte, S.; Faneca, H.; Lima, M.C.P.D., 2012. International Journal of Pharmaceutics. 365 - 377. 2. 423. 2012. hhttps://doi.org/10.1016/j.ijpharm.2011.12.035 . 10.1016/j.ijpharm.2011.12.035 . published International Journal of Pharmaceutics

Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect

Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V., 2012. Oncology Reports. 1057 - 1062. 3. 28. 2012. https://doi.org/10.3892/or.2012.1904 . 10.3892/or.2012.1904 . published Oncology Reports

In situ forming chitosan hydrogels prepared via ionic/covalent co-cross-linking

Moura, M.J.; Faneca, H.; Lima, M.P.; Gil, M.H.; Figueiredo, M.M., 2011. Biomacromolecules. 3275 - 3284. 9. 12. 2011. https://doi.org/10.1021/bm200731x . 10.1021/bm200731x . published Biomacromolecules

Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency

Ana M Cardoso; Faneca, Henrique; João Almeida; Alberto Pais; Eduardo Marques; Maria Pedroso Lima; Amália Jurado, 2011. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2011. http://dx.doi.org/10.1016/j.bbamem.2010.09.026 . 10.1016/j.bbamem.2010.09.026 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

Non-covalent association of folate to lipoplexes: a promising strategy to improve gene delivery in the presence of serum

Duarte, S.; Faneca, H.; Pedroso De Lima, M.C., 2011. Journal of Controlled Release. 264 - 272. 3. 149. 2011. https://doi.org/10.1016/j.jconrel.2010.10.032 . 10.1016/j.jconrel.2010.10.032 . published Journal of Controlled Release

Dicationic alkylammonium bromide gemini surfactants. membrane perturbation and skin irritation

Almeida, J.A.S.; Faneca, H.; Carvalho, R.A.; Marques, E.F.; Pais, A.A.C.C., 2011. PLoS ONE. 11. 6. 2011. https://doi.org/10.1371/journal.pone.0026965 . 10.1371/journal.pone.0026965 . published PLoS ONE

Inclusion of a single-tail amino acid-based amphiphile in a lipoplex formulation: effects on transfection efficiency and physicochemical properties

Lundberg, D.; Faneca, H.; Pedroso De Lima, M.C.; Miguel, M.D.G.; Lindman, B., 2011. Molecular Membrane Biology. 42 - 53. 1. 28. 2011. https://doi.org/10.3109/09687688.2010.508879 . 10.3109/09687688.2010.508879 . published Molecular Membrane Biology

Study of the antidiabetic capacity of the VO(dmpp)2 complex

Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., 2010. Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. https://doi.org/10.1016/j.jinorgbio.2010.05.004 . 10.1016/j.jinorgbio.2010.05.004 . published Journal of Inorganic Biochemistry

Interaction of proteinase inhibitors with phospholipid vesicles is modulated by pH

Silva-Lucca, R.A.; Faneca, H.M.S.; de Lima, M.C.P.; De Caroli, F.P.; Assis, M.L.; Sampaio, M.U.; Oliva, M.L.V., 2010. International Journal of Biological Macromolecules. 551 - 557. 4. 47. 2010. https://doi.org/10.1016/j.ijbiomac.2010.07.011 . 10.1016/j.ijbiomac.2010.07.011 . published International Journal of Biological Macromolecules

Vanadium compounds as therapeutic agents: some chemical and biochemical studies

Faneca, H.; Figueiredo, V.A.; Tomaz, I.; Gonçalves, G.; Avecilla, F.; Pedroso de Lima, M.C.; Geraldes, C.F.G.C.; Pessoa, J.C.; Castro, M.M.C.A., 2009. Journal of Inorganic Biochemistry. 601 - 608. 4. 103. 2009. https://doi.org/10.1016/j.jinorgbio.2008.11.004 . 10.1016/j.jinorgbio.2008.11.004 . published Journal of Inorganic Biochemistry

Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response

Neves, S.; Faneca, H.; Bertin, S.; Konopka, K.; Düzgünes, N.; Pierrefite-Carle, V.; Simões, S.; Pedroso De Lima, M.C., 2009. Cancer Gene Therapy. 91 - 101. 1. 16. 2009. hhttps://doi.org/10.1038/cgt.2008.60 . 10.1038/cgt.2008.60 . published Cancer Gene Therapy

Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes

Faneca, H.; Faustino, A.; Pedroso de Lima, M.C., 2008. Journal of Controlled Release. 175 - 184. 2. 126. 2008. https://doi.org/10.1016/j.jconrel.2007.12.005 . 10.1016/j.jconrel.2007.12.005 . published Journal of Controlled Release

S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA

Sara Trabulo; Miguel Mano; Faneca, Henrique; Ana L Cardoso; Sónia Duarte; Ana Henriques; Artur Paiva; et al, 2008. The Journal of Gene Medicine. 1210 - 1222. 11. 10. 2008. https://doi.org/10.1002/jgm.1247 . 10.1002/jgm.1247 . published The Journal of Gene Medicine

Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when delivered by a novel lipid-based system

Faneca, H.; Cabrita, A.S.; Simões, S.; Pedroso de Lima, M.C., 2007. Biochimica et Biophysica Acta - Biomembranes. 1093 - 1102. 5. 1768. 2007. https://doi.org/10.1016/j.bbamem.2006.12.017 . 10.1016/j.bbamem.2006.12.017 . published Biochimica et Biophysica Acta - Biomembranes

Cationic liposomes for gene delivery

Simões, S.; Filipe, A.; Faneca, H.; Mano, M.; Penacho, N.; Düzgünes, N.; de Lima, M.P., 2005. Expert Opinion on Drug Delivery. 237 - 254. 2. 2. 2005. https://doi.org/10.1517/17425247.2.2.237 . 10.1517/17425247.2.2.237 . published Expert Opinion on Drug Delivery

Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum

Faneca, H.; Simões, S.; Pedroso de Lima, M.C., 2004. Journal of Gene Medicine. 681 - 692. 6. 6. 2004. https://doi.org/10.1002/jgm.550 . 10.1002/jgm.550 . published Journal of Gene Medicine

Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles

Simões, S.; Fonseca, C.; Faneca, H.; Düzgünes, N.; Pedroso de Lima, M.C., 2002. S.T.P. Pharma Sciences. 339 - 344. 6. 12. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036855226&partnerID=MN8TOARS . published S.T.P. Pharma Sciences

Evaluation of lipid-based reagents to mediate intracellular gene delivery

Faneca, H.; Simões, S.; Pedroso de Lima, M.C., 2002. Biochimica et Biophysica Acta - Biomembranes. 23 - 33. SUPPL.. 1567. 2002. https://doi.org/10.1016/S0005-2736(02)00545-X . 10.1016/S0005-2736(02)00545-X . published Biochimica et Biophysica Acta - Biomembranes

Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications

Pedroso De Lima, M.C.; Simões, S.; Pires, P.; Faneca, H.; Düzgünes, N., 2001. Advanced Drug Delivery Reviews. 277 - 294. 2-3. 47. 2001. https://doi.org/10.1016/S0169-409X(01)00110-7 . 10.1016/S0169-409X(01)00110-7 . published Advanced Drug Delivery Reviews

Projectos I&D