Glicose
Neurónio
Glia
Endocanabinóide
Adenosina
Alterações na neuromodulação dos terminais corticostriatal em um modelo de rato com doença de Willis-Ekbom
Investigar o papel de A2ARs de adenosina na glicorregulação cerebral
O novo receptor de endocanabinoide, GPR55 estimula a glicólise em astrócitos
Modulação dependente do estado de alimentação da plasticidade sináptica hipocampal pela insulina
O metabolismo da glicose no cérebro está fortemente acoplado à atividade neuronal. Nós investigamos como os moduladores da atividade neuronal regulam o metabolismo da glicose no cérebro. Os neuromoduladores em que estamos atualmente interessados e que apresentam potencial terapêutico promissor são a adenosina, endocanabinóides e peptídeos semelhantes à insulina. Por que essa pesquisa é importante? Todos os distúrbios neurológicos e psiquiátricos estão ligados a mudanças persistentes no metabolismo da glicose em regiões muito específicas do cérebro humano. 18F-desoxiglicose e imagens funcionais de ressonância magnética ajudam os neurologistas a detectar essas alterações. Essas desregulações metabólicas geralmente precedem a neurodegeneração por anos. Portanto, compreender os marcadores iniciais seletivos de distúrbios cerebrais pode ajudar os médicos a categorizar a doença e selecionar os tratamentos apropriados o mais cedo possível. Muitas vezes, o reconhecimento precoce da doença e a decisão rápida sobre o tratamento fazem a diferença. Assim, também gostaríamos de saber se a restauração da glicorregulação cerebral parturbada poderia melhorar o desfecho de determinada doença cerebral, ou mesmo prevenir o aparecimento dela. Estamos estudando sistemas básicos de sinalização, tanto in vitro quanto in vivo em modelos animais, com o objetivo futuro de testar novamente as idéias promissoras em humanos. Usamos principalmente neuroquímica, citometria de fluxo, microscopia, eletrofisiologia em fatias de cérebro e culturas de células e comportamento in vivo em modelos de doenças de roedores.
Informação sobre artigos em revista, actualizada a 16-02-2025, a partir da plataforma CIÊNCIAVITAE.
Comparing adenosine A2A receptor modulation of cannabinoid CB1 receptor-mediated inhibition of GABA and glutamate release in rodent striatal nerve terminals
Samira G. Ferreira; Rafael M. Bitencourt; Pedro Garção; Rodrigo A. Cunha; Attila Köfalvi, 2025. European Journal of Neuroscience. 2025. https://doi.org/10.1111/ejn.16642 . 10.1111/ejn.16642 . European Journal of Neuroscience
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Ricardo J. Rodrigues; Joana M. Marques; Attila Köfalvi, 2024. Cells. 2024. https://doi.org/10.3390/cells13221875 . 10.3390/cells13221875 . Cells
Targeting corticostriatal transmission for the treatment of cannabinoid use disorder
Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis, 2023. Trends in Pharmacological Sciences. 495 - 506. 8. 44. 2023. http://dx.doi.org/10.1016/j.tips.2023.05.003 . 10.1016/j.tips.2023.05.003 . Trends in Pharmacological Sciences
Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome
Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules
Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.
Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology
The Yin and Yang of Adenosine Receptors: A Piquant Story
Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism
Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro
Boosting brain glucose metabolism to fight neurodegeneration?
de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .
Conference Paper: Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression.
Leal, Ermelindo C; Pirzgalska R; Dorinda Marques-da-Silva; Moura, Liane; Espinoza D; Ledent, C.; Köfalvi, Attila; Carvalho, Eugenia, 2017. Diabetologia. 119 - 119. S1. 60. 2017. http://dx.doi.org/10.1007/s00125-017-4350-z . 10.1007/s00125-017-4350-z . Diabetologia
Cannabis: A Treasure Trove or Pandora's Box?
Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry
Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses
Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al, 2016. Molecular Neurobiology. 1552 - 1563. 2. 54. 2016. https://doi.org/10.1007%2Fs12035-016-9774-9 . 10.1007/s12035-016-9774-9 . Molecular Neurobiology
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. https://doi.org/10.1016/j.brainresbull.2016.05.009 . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease
Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. https://doi.org/10.1016/j.neuropharm.2016.03.015 . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2016. 2016. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .
Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents
Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al, 2015. Neurochemistry International. 2015. http://dx.doi.org/10.1016/j.neuint.2015.07.014 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International
Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices
Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones, 2015. NMR Biomed.. 1111 - 1116. 9. 28. 2015. http://dx.doi.org/10.1002/nbm.3355 . 10.1002/nbm.3355 . NMR Biomed.
Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus
Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience
Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology
Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain
Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://dx.doi.org/10.1007/s11302-015-9474-3 . 10.1007/s11302-015-9474-3 . Purinergic Signalling
Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al, 2014. PLoS ONE. 12. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0114216 . 10.1371/journal.pone.0114216 . PLoS ONE
Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain
Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A., 2013. Brain Research Bulletin. 126 - 135. 97. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS . 10.1016/j.brainresbull.2013.06.007 . Brain Research Bulletin
Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder
Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A., 2013. European Neuropsychopharmacology. 317 - 328. 4. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS . 10.1016/j.euroneuro.2012.04.011 . European Neuropsychopharmacology
Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum
Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology
Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach
Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A., 2012. Journal of Neuroscience Methods. 366 - 373. 2. 204. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS . 10.1016/j.jneumeth.2011.11.028 . Journal of Neuroscience Methods
Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat
Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B., 2012. Neuropharmacology. 784 - 797. 5. 63. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS . 10.1016/j.neuropharm.2012.06.003 . Neuropharmacology
CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus
Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International
Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences
Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International
Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.
Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia, 2011. Diabetologia. 458 - 458. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain
Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging
De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology
Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry
Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology
Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina
Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research
Conferenc Paper: Chronic caffeine treatment during adolescence improves behavioral flexibility in an animal model of attention deficit hyperactivity disorder.
Pandolfo, P.; Machado NM; Köfalvi, Attila; Takahashi RN; Cunha, Rodrigo A., 2010. Purinergic Signalling. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Blockade of synaptic adenosine A2A receptor prevents convulsion-induced damage.
Augusto, Elisabete; Paula M. Canas; Lisiane O. Porciúncula; Tiago M. Alfaro; Andrade GM; Köfalvi, Attila; Agostinho PM; Cunha, Rodrigo A., 2010. Purinergic Signalling. 108 - 108. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Presynaptic A2A adenosine and CB1 cannabinoid receptors inhibit the function of one another at corticostriatal terminals.
Ferreira, Samira G.; Köfalvi, Attila; Cunha, Rodrigo A., 2010. Purinergic Signalling. 44 - 44. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Complex regulation of CB1-mediated effects by activation and blockade of striatal adenosine A2A receptors.
Tebano MT; Martire, A.; Köfalvi, Attila; Chiodi, V.; Ferrante A; Domenici MR; Ferreira, Samira G.; Cunha, Rodrigo A.; Popoli, P., 2010. Purinergic Signalling. 19 - 19. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Conferenc Paper: Dual regulatory role of pre- and post-synaptic adenosine A2A receptors on CB1-mediated effects in the striatum.
Tebano MT; Martire A; Köfalvi, Attila; Chiodi, V.; Domenici MR; Pepponi R; Ferrante A; et al, 2009. Purinergic Signalling. 51 - 51. 1. 6. 2009. http://dx.doi.org/10.1007/s11302-009-9171-1 . 10.1007/s11302-009-9171-1 . Purinergic Signalling
Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum
Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience
Conferenc Paper: When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis.
Köfalvi, Attila, 2009. Journal of Neurochemistry. 103 - 104. s1. 110. 2009. http://dx.doi.org/10.1111/j.1471-4159.2009.06064_27.x . 10.1111/j.1471-4159.2009.06064_27.x . Journal of Neurochemistry
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology
Conferenc Paper: CB1 cannabinoid receptors in the physiopathology of hippocampal glucose homeostasis.
Duarte, JMN; Nogueira, C.; Carvalho; Mackie, K.; Oliveira, CR; Cunha, Rodrigo A.; Köfalvi, Attila, 2007. Journal of Neurochemistry. 115 - 115. s1. 102. 2007. http://dx.doi.org/10.1111/j.0022-3042.2007.04727.x . 10.1111/j.0022-3042.2007.04727.x . Journal of Neurochemistry
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience
Regulation of neurotransmitter release by presynaptic P2X receptors
Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters
Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia
Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience
Conferenc Paper: The role of presynaptic P2X receptors in the regulation of tritiated NA release from rat hippocampal slices.
Papp, L.; Balázsa, T.; Köfalvi, Attila; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 37 - 37. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
Conferenc Paper: Regulation of transmitter release in the CNS by cannabinoid receptors.
Sperlágh, B.; Köfalvi, Attila; E. Sylvester Vizi, 2004. Pharmacology. 141 - 141. 2. 72. 2004. http://dx.doi.org/10.1159/000080185 . 10.1159/000080185 . Pharmacology
Conferenc Paper: Ischemia induced up-regulation of P2X7 receptors on GABAergic neurons in corticoencephalic cell cultures.
Günther, A.; Köfalvi, Attila; Reinhardt, R.; Franke, F.; Madarász, E.; Vizi, E. Sylvester; Schneider, D.; et al, 2004. European Journal of Neurology. 58 - 58. s2. 11. 2004. http://dx.doi.org/10.1111/j.1468-1331.2004.00919.x . 10.1111/j.1468-1331.2004.00919.x . European Journal of Neurology
Conferenc Paper: Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the rodent striatum.
Köfalvi, Attila; Ricardo J. Rodrigues; Cunha, Rodrigo A.; Catherine Ledent; Vizi, E. Sylvester; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 57 - 57. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices
Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action
Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry
Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord
Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International
Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens
Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research
Conferenc Paper: ATP releases [3H]GABA from rat hippocampal slices via P2X7 receptor activation.
Köfalvi, Attila; Baranyi M; Vizi ES; Sperlagh, B., 2001. Fundamental and Clinical Pharmacology. 135 - 135. S1. 15. 2001. http://dx.doi.org/10.1046/j.1472-8206.2001.00113.x . 10.1046/j.1472-8206.2001.00113.x . Fundamental and Clinical Pharmacology
Cellular Neurophysiology
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; E. Sylvester Vizi; Sperlagh, B., 2000. Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus. . suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
Conference Paper: Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; Vizi ES; Sperlágh, B., 2000. The Journal of Physiology. 64 - 65. suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . The Journal of Physiology
Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation
Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience
Conference Paper: The Effect of Nicotine on GABA Release from Rat Hippocampal Slices is Mediated via alpha7-Type Homopentameric Neuronal Nicotinic Acetylcholine Receptors
Köfalvi, Attila; E. Sylvester Vizi; Beáta Sperlágh, 1999. Fundamental and Clinical Pharmacology. S1. 13. 1999. http://dx.doi.org/10.1111/j.1472-8206.1999.tb00383.x . 10.1111/j.1472-8206.1999.tb00383.x . Fundamental and Clinical Pharmacology
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 1999. Journal of Neuroscience. 4544 - 4558. 11. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS . Journal of Neuroscience
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