Diabetes
Resistência à insulina
Adipócitos
microRNAs
Respiração mitocondrial
Estudos de longevidade
Cicatrização e regeneração de tecidos em condições diabéticas
Capacidade oxidativa de células circulantes ao longo da vida
O grupo de investigação em Obesidade, Diabetes e Complicações, liderado pela Dra. Eugénia Carvalho tem vindo a estudar o papel do tecido adiposo (AT) como órgão endócrino e inflamatório. O AT encontra-se profundamente envolvido no desenvolvimento da resistência à insulina e complicações resultantes da diabetes. A sua equipa utiliza sistemas in vitro, modelos pré-clínicos, assim como estudos clínicos para perceber o estado de disfunção do AT ao longo da vida. O grupo encontra-se a estudar o impacto do imunometabolismo do AT e os seus efeitos a nível sistémico de pessoas com diferentes graus de resistência à insulina. A sua equipa está ainda avaliar diferenças entre vários depósitos de AT e as suas respetivas atividades mitocondriais. Além disso, Dra. Carvalho acredita que a capacidade oxidativa das células/tecidos pode servir como marcador para doenças, antes dos seus sintomas aparecerem, ou mesmo antes do seu diagnóstico. Ela tem vindo a avaliar a função mitocondrial em células circulantes em adultos e crianças com obesidade. O principal objetivo é perceber alterações iniciais no metabolismo imune e como estas se relacionam com distúrbios metabólicos ao longo da vida. Além disso, Dra. Carvalho também acredita que fatores ambientais como a falta de nutrientes específicos, fármacos e o estilo de vida influenciam fortemente a saúde metabólica mitocondrial e imune, assim como o fenótipo específico das células gordas. Assim, perceber o impacto de nutraceuticos para promover a saúde metabólica é um objetivo.
A sua equipa tem vindo também avaliar a regeneração de tecidos e a cura de feridas no contexto da resistência à insulina e diabetes, com o objetivo de melhorar o diagnóstico precoce de indivíduos em risco de complicações crónicas, a fim de melhorar o tratamento personalizado de indivíduos com úlceras do pé diabético. Por fim, encontram-se ainda avaliar o papel dos microRNAs e de péptidos antimicrobianos na infecção e cicatrização de feridas em modelos pré-clínicos e em ambiente clínico em indivíduos diabéticos.
Informação sobre artigos em revista, actualizada a 01-12-2024, a partir da plataforma CIÊNCIAVITAE.
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.
Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. http://europepmc.org/abstract/med/27686967 . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, 2021. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/2207125 . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity
Impaired T-cell differentiation in diabetic foot ulceration.
Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. http://europepmc.org/abstract/med/26996067 . 10.1038/cmi.2015.116 . Cellular & molecular immunology
Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry
Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling
Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell
Neurotensin, substance P, and insulin enhance cell migration
Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science
Immune aging in diabetes and its implications in wound healing
Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology
Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota
Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, 2021. Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing
Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences
5 11 de 11 Publicações em destaque
Informação sobre artigos em revista, actualizada a 01-12-2024, a partir da plataforma CIÊNCIAVITAE.
Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
Pedro Barbosa; Aryane Pinho; André Lázaro; Diogo Paula; José G. Tralhão; Artur Paiva; Maria J. Pereira; Eugenia Carvalho; Paula Laranjeira, 2024. Biomolecules. 2024. https://doi.org/10.3390/biom14020219 . 10.3390/biom14020219 . Biomolecules
The role of CD20+ T cells: Insights in human peripheral blood
Aryane Cruz Oliveira Pinho; Pedro Barbosa; Maria João Pereira; Artur Paiva; Eugenia Carvalho; Paula Laranjeira, 2024. Cytometry Part B: Clinical Cytometry. 2024. https://doi.org/10.1002/cyto.b.22178 . 10.1002/cyto.b.22178 . Cytometry Part B: Clinical Cytometry
Role of CD20+ T cells in cancer, autoimmunity and obesity
Aryane Cruz Oliveira Pinho; Paula Laranjeira; Eugenia Carvalho, 2024. Journal of Endocrinology. 2024. https://doi.org/10.1530/JOE-23-0242 . 10.1530/JOE-23-0242 . Journal of Endocrinology
Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal, 2023. Antibiotics. 2023. https://doi.org/10.3390/antibiotics12030467 . 10.3390/antibiotics12030467 . Antibiotics
Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?
Pedro Barbosa; Eugenia Carvalho, 2023. Diabetology. 2023. https://doi.org/10.3390/diabetology4010005 . 10.3390/diabetology4010005 . Diabetology
Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study
Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho, 2023. European Journal of Clinical Investigation. 2023. https://doi.org/10.1111/eci.14128 . 10.1111/eci.14128 . European Journal of Clinical Investigation
Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers
Jessica Da Silva; Ermelindo C. Leal; Eugénia Carvalho; Eduardo A. Silva, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24129900 . 10.3390/ijms24129900 . International Journal of Molecular Sciences
Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes
Alphonse Laya; Honoré Wangso; Iva Fernandes; Raphaël Djakba; Joana Oliveira; Eugenia Carvalho; Wen yi Kang, 2023. Journal of Food Quality. 2023. https://doi.org/10.1155/2023/5236509 . 10.1155/2023/5236509 . Journal of Food Quality
Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model
Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho, 2023. Journal of Molecular Endocrinology. 2023. https://doi.org/10.1530/JME-22-0122 . 10.1530/JME-22-0122 . Journal of Molecular Endocrinology
Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning
M. Graça Pereira; Margarida Vilaça; Diogo Braga; Ana Madureira; Jéssica Da Silva; Diana Santos; Eugénia Carvalho, 2023. Wound Repair and Regeneration. 2023. https://doi.org/10.1111/wrr.13141 . 10.1111/wrr.13141 . Wound Repair and Regeneration
Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study
Jessica Da Silva; Diana Santos; Margarida Vilaça; André Carvalho; Rui Carvalho; Maria de Jesus Dantas; M. Graça Pereira; Eugénia Carvalho, 2023. Advances in Wound Care. 2023. https://doi.org/10.1089/wound.2023.0043 . 10.1089/wound.2023.0043 . Advances in Wound Care
Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity
Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho, 2023. Life Sciences. 2023. https://doi.org/10.1016/j.lfs.2022.121246 . 10.1016/j.lfs.2022.121246 . Life Sciences
Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers
M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho, 2022. International Journal of Environmental Research and Public Health. 2022. https://doi.org/10.3390/ijerph19148556 . 10.3390/ijerph19148556 . International Journal of Environmental Research and Public Health
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers
Ermelindo Carreira Leal; Eugenia Carvalho, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231912043 . 10.3390/ijms231912043 . International Journal of Molecular Sciences
The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention
Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho, 2022. Metabolites. 2022. https://doi.org/10.3390/metabo12020184 . 10.3390/metabo12020184 . Metabolites
Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue
Diana Santos; Eugenia Carvalho, 2021. The Journal of Physiology. 2021. https://doi.org/10.1113/JP280917 . 10.1113/JP280917 . The Journal of Physiology
Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial
Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO, 2021. Annals of the Brazilian Academy of Sciences. 1. 94. 2021. https://doi.org/10.1590/0001-3765202220201819 . 10.1590/0001-3765202220201819 . accepted Annals of the Brazilian Academy of Sciences
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al, 2021. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/2207125 . 10.1155/2021/2207125 . Oxidative Medicine and Cellular Longevity
Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota
Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al, 2021. Molecular Therapy - Methods & Clinical Development. 2021. accepted Molecular Therapy - Methods & Clinical Development
mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate
Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia, 2021. Stem Cell Reviews and Reports. 2021. https://doi.org/10.1007/s12015-021-10131-z . 10.1007/s12015-021-10131-z . accepted Stem Cell Reviews and Reports
Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al, 2021. The Journal of Nutritional Biochemistry. 2021. http://dx.doi.org/10.1016/j.jnutbio.2021.108817 . 10.1016/j.jnutbio.2021.108817 . The Journal of Nutritional Biochemistry
Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds
Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho, 2021. Current Diabetes Reviews. 2021. https://doi.org/10.2174/1573399817666210806112813 . 10.2174/1573399817666210806112813 . Current Diabetes Reviews
Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice
Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet, 2021. JBMR Plus. 7. 5. 2021. http://dx.doi.org/10.1002/jbm4.10508 . 10.1002/jbm4.10508 . JBMR Plus
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing
Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia, 2020. Life Sciences. 254. 2020. http://dx.doi.org/10.1016/j.lfs.2020.117813 . 10.1016/j.lfs.2020.117813 . Life Sciences
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk
Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi, 2020. BMC Nutrition. 1. 6. 2020. http://dx.doi.org/10.1186/s40795-020-00338-7 . 10.1186/s40795-020-00338-7 . BMC Nutrition
Mechanistic Actions of microRNAs in Diabetic Wound Healing
Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp, 2020. Cells. 10. 9. 2020. http://dx.doi.org/10.3390/cells9102228 . 10.3390/cells9102228 . Cells
Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling
Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al, 2020. Aging Cell. 11. 19. 2020. http://dx.doi.org/10.1111/acel.13261 . 10.1111/acel.13261 . Aging Cell
Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes
Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia, 2020. Pharmacological Research. 159. 2020. http://dx.doi.org/10.1016/j.phrs.2020.104977 . 10.1016/j.phrs.2020.104977 . Pharmacological Research
Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P., 2020. Microorganisms. 10. 8. 2020. http://dx.doi.org/10.3390/microorganisms8101500 . 10.3390/microorganisms8101500 . Microorganisms
Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration
Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia, 2019. Cellular & Molecular Immunology. 2019. http://dx.doi.org/10.1038/s41423-019-0233-1 . 10.1038/s41423-019-0233-1 . Cellular & Molecular Immunology
Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model
Carvalho, Eugenia, 2019. Cellular Physiology and Biochemistry. 503 - 516. 3. 52. 2019. http://dx.doi.org/10.33594/000000036 . 10.33594/000000036 . Cellular Physiology and Biochemistry
Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain
Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi, 2019. Brain Research Bulletin. 2019. https://doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation
Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al, 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-42309-4 . 10.1038/s41598-019-42309-4 . Scientific Reports
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, 2019. ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
Immune aging in diabetes and its implications in wound healing
Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E., 2019. Clinical Immunology. 43 - 54. 200. 2019. http://dx.doi.org/10.1016/j.clim.2019.02.002 . 10.1016/j.clim.2019.02.002 . Clinical Immunology
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women
Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet, 2019. American Journal of Physiology-Endocrinology and Metabolism. E503 - E512. 3. 317. 2019. http://dx.doi.org/10.1152/ajpendo.00084.2019 . 10.1152/ajpendo.00084.2019 . American Journal of Physiology-Endocrinology and Metabolism
Neurotensin, substance P, and insulin enhance cell migration
Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen, 2018. Journal of Peptide Science. e3093 - e3093. 7. 24. 2018. https://doi.org/10.1002/psc.3093 . 10.1002/psc.3093 . Journal of Peptide Science
Calcineurin is an important factor involved in glucose uptake in human adipocytes
Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira, 2018. Molecular and Cellular Biochemistry. 157 - 168. 1-2. 445. 2018. https://doi.org/10.1007/s11010-017-3261-0 . 10.1007/s11010-017-3261-0 . Molecular and Cellular Biochemistry
Wanted: MicroRNAs to the aid of the diabetic foot
Louise T. Dalgaard; Eugenia Carvalho, 2018. Trends in Cardiovascular Medicine. 2018. https://doi.org/10.1016/j.tcm.2018.09.002 . 10.1016/j.tcm.2018.09.002 . Trends in Cardiovascular Medicine
Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults
Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet, 2017. Current Developments in Nutrition. 11. 1. 2017. http://dx.doi.org/10.3945/cdn.117.002071 . 10.3945/cdn.117.002071 . Current Developments in Nutrition
Impaired T-cell differentiation in diabetic foot ulceration.
Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E, 2017. Cellular & molecular immunology. 2017. http://europepmc.org/abstract/med/26996067 . 10.1038/cmi.2015.116 . Cellular & molecular immunology
Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.
Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E, 2017. Nutrients. 2017. http://europepmc.org/abstract/med/28635632 . 10.3390/nu9060638 . Nutrients
Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.
Pereira SG; Moura J; Carvalho E; Empadinhas N, 2017. Frontiers in microbiology. 2017. http://europepmc.org/abstract/med/28983285 . 10.3389/fmicb.2017.01791 . Frontiers in microbiology
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al, 2016. Biochimica et biophysica acta. 2016. http://europepmc.org/abstract/med/27686967 . 10.1016/j.bbalip.2016.09.016 . Biochimica et biophysica acta
Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.
Emanuelli T; Burgeiro A; Carvalho E, 2016. Archives of dermatological research. 2016. http://europepmc.org/abstract/med/27655635 . 10.1007/s00403-016-1686-z . Archives of dermatological research
Reply to Katlandur, Ozbek, and Keser.
Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/27182058 . 10.1152/ajpendo.00113.2016 . American journal of physiology. Endocrinology and metabolism
Mast Cells Regulate Wound Healing in Diabetes.
Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al, 2016. Diabetes. 2016. http://europepmc.org/abstract/med/27207516 . 10.2337/db15-0340 . Diabetes
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.
Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al, 2016. American journal of physiology. Endocrinology and metabolism. 2016. http://europepmc.org/abstract/med/26814014 . 10.1152/ajpendo.00384.2015 . American journal of physiology. Endocrinology and metabolism
Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat
Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F., 2015. Journal of Physiology and Pharmacology. 285 - 299. 2. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927565139&partnerID=MN8TOARS . Journal of Physiology and Pharmacology
The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?
Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F, 2015. Journal of diabetes research. 2015. http://europepmc.org/abstract/med/26075286 . 10.1155/2015/806979 . Journal of diabetes research
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Carvalho, Eugenia, 2015. Am J Pathol. 2015. http://www.ncbi.nlm.nih.gov/pubmed/25871534 . Am J Pathol
Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing
Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E.; Moura, Liane I F; et al, 2014. Acta Biomaterialia. 843 - 857. 2. 10. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896548394&partnerID=MN8TOARS . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia
Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model
Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E., 2014. Biochemical Pharmacology. 216 - 228. 2. 88. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895553061&partnerID=MN8TOARS . 10.1016/j.bcp.2014.01.020 . Biochemical Pharmacology
The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes
Moura, L.I.; Cruz, M.T.; Carvalho, E., 2014. Experimental Biology and Medicine. 6 - 12. 1. 239. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891928865&partnerID=MN8TOARS . 10.1177/1535370213510665 . Experimental Biology and Medicine
Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression
Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2014. International Journal of Inflammation. 2014. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907386743&partnerID=MN8TOARS . 10.1155/2014/248240 . International Journal of Inflammation
Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment
Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Biochemical Pharmacology. 61 - 73. 1. 91. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905441039&partnerID=MN8TOARS . 10.1016/j.bcp.2014.06.014 . Biochemical Pharmacology
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model
Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al, 2014. International Journal of Molecular Sciences. 8979 - 8997. 5. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901366149&partnerID=MN8TOARS . 10.3390/ijms15058979 . International Journal of Molecular Sciences
The role of micrornas in diabetic complications—special emphasis on wound healing
Moura, J.; Børsheim, E.; Carvalho, E., 2014. Genes. 926 - 956. 4. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919594907&partnerID=MN8TOARS . 10.3390/genes5040926 . Genes
Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats
Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E., 2014. Metabolism: Clinical and Experimental. 702 - 715. 5. 63. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899413762&partnerID=MN8TOARS . 10.1016/j.metabol.2014.02.004 . Metabolism: Clinical and Experimental
Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review
Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C., 2013. Acta Biomaterialia. 7093 - 7114. 7. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878278772&partnerID=MN8TOARS . 10.1016/j.actbio.2013.03.033 . Acta Biomaterialia
Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus
Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al, 2013. Transplantation Proceedings. 1149 - 1156. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876882818&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.085 . Transplantation Proceedings
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers
Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, 2013. PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS . 10.1371/journal.pone.0083314 . PLoS ONE
Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing
Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., 2013. Archives of Dermatological Research. 557 - 569. 7. 305. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883240109&partnerID=MN8TOARS . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research
Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions
Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884259661&partnerID=MN8TOARS . 10.1155/2013/941764 . BioMed Research International
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W.; et al, 2013. Molecular and Cellular Endocrinology. 260 - 269. 2. 365. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871359857&partnerID=MN8TOARS . 10.1016/j.mce.2012.10.030 . Molecular and Cellular Endocrinology
Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model
Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E., 2013. Transplantation Proceedings. 1142 - 1148. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876870991&partnerID=MN8TOARS . 10.1016/j.transproceed.2013.02.009 . Transplantation Proceedings
Increased skin inflammation and blood vessel density in human and experimental diabetes
Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, 2013. International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds
Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker
Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F., 2013. Cardiovascular Diabetology. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874618884&partnerID=MN8TOARS . 10.1186/1475-2840-12-44 . Cardiovascular Diabetology
Spatial memory impairments in a prediabetic rat model
Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, 2013. Neuroscience. 565 - 577. 250. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.07.055 . Neuroscience
Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease
Cherian, S.; Lopaschuk, G.D.; Carvalho, E., 2012. American Journal of Physiology - Endocrinology and Metabolism. 8. 303. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867609320&partnerID=MN8TOARS . 10.1152/ajpendo.00061.2012 . American Journal of Physiology - Endocrinology and Metabolism
Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model
Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F., 2012. Journal of Pharmacology and Pharmacotherapeutics. 143 - 148. 2. 3. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878801249&partnerID=MN8TOARS . 10.4103/0976-500X.95513 . Journal of Pharmacology and Pharmacotherapeutics
Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells
Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE
Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression
da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E., 2011. Biochimica et Biophysica Acta - Molecular Cell Research. 1863 - 1871. 10. 1813. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051782996&partnerID=MN8TOARS . 10.1016/j.bbamcr.2011.06.018 . Biochimica et Biophysica Acta - Molecular Cell Research
Study of the antidiabetic capacity of the VO(dmpp)2 complex
Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A., 2010. Journal of Inorganic Biochemistry. 987 - 992. 9. 104. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955091334&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2010.05.004 . Journal of Inorganic Biochemistry
Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing
Da Silva, L.; Carvalho, E.; Cruz, M.T., 2010. Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy
Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes
Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M.; Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C., 2009. Journal of Inorganic Biochemistry. 1687 - 1692. 12. 103. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350566106&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2009.09.015 . Journal of Inorganic Biochemistry
Elimination of glucose contamination from adipocyte glycogen extracts
Nunes, P.M.; Carvalho, E.; Jones, J.G.; Nunes, Patricia M.; Carvalho, Eugénia; Jones, John G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS . 10.1016/j.carres.2008.04.004 . Carbohydrate Research
Substance P as a Novel Anti-obesity Target
Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E., 2008. Gastroenterology. 3. 134. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749152943&partnerID=MN8TOARS . 10.1053/j.gastro.2007.12.032 . Gastroenterology
Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle
Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B., 2005. American Journal of Physiology - Endocrinology and Metabolism. 4 52-4. 289. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044440661&partnerID=MN8TOARS . 10.1152/ajpendo.00116.2005 . American Journal of Physiology - Endocrinology and Metabolism
GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase
Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al, 2004. Journal of Biological Chemistry. 21598 - 21605. 20. 279. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442636649&partnerID=MN8TOARS . 10.1074/jbc.M312269200 . Journal of Biological Chemistry
Evidence of impaired adipogenesis in insulin resistance
Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U., 2004. Biochemical and Biophysical Research Communications. 1045 - 1051. 4. 317. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484345&partnerID=MN8TOARS . 10.1016/j.bbrc.2004.03.152 . Biochemical and Biophysical Research Communications
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin
Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al, 2003. FASEB Journal. 1434 - 1440. 11. 17. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042209622&partnerID=MN8TOARS . 10.1096/fj.02-1132com . FASEB Journal
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.
Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1101 - 1103. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects
Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U., 2000. Diabetologia. 1107 - 1115. 9. 43. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033811737&partnerID=MN8TOARS . 10.1007/s001250051501 . Diabetologia
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes
Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C., 2000. Biochemical and Biophysical Research Communications. 315 - 320. 2. 268. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034673376&partnerID=MN8TOARS . 10.1006/bbrc.2000.2145 . Biochemical and Biophysical Research Communications
Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
Carvalho, E.; Rondinone, C.; Smith, U., 2000. Molecular and Cellular Biochemistry. 7 - 16. 1-2. 206. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034055787&partnerID=MN8TOARS . Molecular and Cellular Biochemistry
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P., 2000. Journal of Biological Chemistry. 10093 - 10098. 14. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616384&partnerID=MN8TOARS . 10.1074/jbc.275.14.10093 . Journal of Biological Chemistry
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus
Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P., 1999. Diabetologia. 819 - 825. 7. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032765342&partnerID=MN8TOARS . 10.1007/s001250051232 . Diabetologia
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U., 1999. FASEB Journal. 2173 - 2178. 15. 13. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779156&partnerID=MN8TOARS . FASEB Journal
Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme
Carvalho, E.; Aasa, R.; Göthe, P.-O., 1996. Journal of Inorganic Biochemistry. 147 - 153. 2. 62. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029971610&partnerID=MN8TOARS . 10.1016/0162-0134(95)00143-3 . Journal of Inorganic Biochemistry
Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme
Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L., 1995. European Journal of Biochemistry. 780 - 785. 3. 234. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557383&partnerID=MN8TOARS . European Journal of Biochemistry
5 92 de 92 Publicações
MMeta4Obesity - Mycobiota homeostasis under the regulation of adenosine receptors as pivotal players in obesity
2022-09-01
Diagnóstico, gestão, prevenção e educação da diabetes na Guiné-Bissau
2021-10-01
Contribuição dos fatores psicológicos na cura da úlcera do pé diabético
2018-09-01
TREATMENT - Disfunção metabólica induzida por drogas antipsicóticas
2017-09-30
Células T CD20 + como biomarcadores de estado inflamatório e um alvo promissor contra a rejeição cardíaca em pacientes cardíacos transplantados
2018-09-30
5 6 de 6 Projectos Passados de I&D
Este website utiliza cookies para melhorar a sua experiência.
