Publications
Information about journal articles, updated at 24-11-2024, from platform CIÊNCIAVITAE.
Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC derived neurons
Beatriz, Margarida; Ricardo Rodrigues; Rita Pereira Vilaça (B317-85CF-B04B); Conceição Egas; Paulo César Silva Pinheiro; Daley, George Q.; Schlaeger, Thorsten M.; et al, Theranostics. 3707 - 3724. 11. 13. 2023. published Theranostics
Defective mitophagic clearance of damaged mitochondria promotes extracellular vesicle-mediated release of mitochondrial components in huntington's disease
Beatriz, Margarida; Vilaça, Rita; Ana Cristina Carvalho Rego; Lopes, Carla, European Journal of Clinical Investigation. S1. 52. 2022. http://dx.doi.org/10.1111/eci.13796 . 10.1111/eci.13796 . published European Journal of Clinical Investigation
Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease
Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla, Journal of Extracellular Biology. 10. 1. 2022. http://dx.doi.org/10.1002/jex2.65 . 10.1002/jex2.65 . published Journal of Extracellular Biology
Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders
Deus, Cláudia M.; Tavares, Henrique; Beatriz, Margarida; Mota, Sandra; Lopes, Carla, Cells. 15. 11. 2022. http://dx.doi.org/10.3390/cells11152364 . 10.3390/cells11152364 . Cells
Mitochondrial and redox modifications in early stages of Huntington's disease
Lopes, Carla; Ferreira, I. Luísa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, José; Castelhano, João; et al, Redox Biology. 2022. http://dx.doi.org/10.1016/j.redox.2022.102424 . 10.1016/j.redox.2022.102424 . Redox Biology
Exosomes: Innocent bystanders or critical culprits in neurodegenerative diseases
Beatriz, Margarida; Vilaça, Rita; Lopes, Carla, Frontiers in Cell and Developmental Biology. 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155522/ . published Frontiers in Cell and Developmental Biology
Revisiting cell and gene therapies in Huntington's disease
Beatriz, Margarida; Lopes, Carla; Ribeiro, Ana Cláudia S.; Rego, Ana Cristina Carvalho, Journal of Neuroscience Research. 1744 - 1762. 7. 99. 2021. http://dx.doi.org/10.1002/jnr.24845 . 10.1002/jnr.24845 . Journal of Neuroscience Research
The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
Naia, Luana; Ly, Philip; Mota, Sandra I.; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al, Neurotherapeutics. 2021. http://dx.doi.org/10.1007/s13311-021-01022-9 . 10.1007/s13311-021-01022-9 . published Neurotherapeutics
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics
Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al, Free Radical Biology and Medicine. 163 - 179. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031 . 10.1016/j.freeradbiomed.2020.11.031 . published Free Radical Biology and Medicine
Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers
Lopes, Carla; Castelhano, Joao; Margarida Fernandes Beatriz (431D-E8EB-DA99); Carolina Fernandes; Mário Laço; Cristina Januário; Abrunhosa, Antero J; Castelo-Branco, Miguel; Ana Cristina Carvalho Rego, European Journal of Clinical Investigation. S1. 50. 2020. http://dx.doi.org/10.1111/eci.13369 . 10.1111/eci.13369 . European Journal of Clinical Investigation
Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics
Beatriz, Margarida; Rita Pereira Vilaça (B317-85CF-B04B); Thorsten Michael Schlaeger; Daley, George Q.; Ana Cristina Carvalho Rego; Lopes, Carla, European Journal of Clinical Investigation. S1. 50. 2020. http://dx.doi.org/10.1111/eci.13369 . 10.1111/eci.13369 . European Journal of Clinical Investigation
Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
Lopes, Carla; Tang, Yang; Anjo, Sandra I.; Manadas, Bruno; Onofre, Isabel; de Almeida, Luís P.; Daley, George Q.; Schlaeger, Thorsten M.; Rego, Ana Cristina Carvalho, Frontiers in Cell and Developmental Biology. 8. 2020. http://dx.doi.org/10.3389/fcell.2020.576592 . 10.3389/fcell.2020.576592 . published Frontiers in Cell and Developmental Biology
Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington´s Disease patient-derived pluripotent and neural stem cells
Lopes, Carla; Schlaeger, Thorsten; Pereira de Almeida, Luis ; Daley, George Q.; Ana Cristina Carvalho Rego, European Journal of Clinical Investigation. 53 - 100. S1. 49. 2019. http://dx.doi.org/10.1111/eci.13108 . 10.1111/eci.13108 . European Journal of Clinical Investigation
Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant
Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al, Neuromuscular Disorders. 350 - 360. 4. 28. 2018. http://dx.doi.org/10.1016/j.nmd.2017.11.006 . 10.1016/j.nmd.2017.11.006 . published Neuromuscular Disorders
SIRT 3 , a modifier of mitochondrial function in Huntington's disease
Naia, Luana; Carmo, Catarina; Campesan, Susanna; Lopes, Carla; Valero, Jorge; Rosenstock, Tatiana R.; Giorgini, Flaviano; Cristina Rego, A., Free Radical Biology and Medicine. 120. 2018. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.072 . 10.1016/j.freeradbiomed.2018.04.072 . published Free Radical Biology and Medicine
Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?
Lopes, Carla; Rego, A. Cristina, Molecular Neurobiology. 1858 - 1873. 3. 54. 2016. http://dx.doi.org/10.1007/s12035-016-9714-8 . 10.1007/s12035-016-9714-8 . published Molecular Neurobiology
Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells
Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Barnat, Monia; Rego, Ana Cristina; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Blum, David, PLOS ONE. e0148680 - e0148680. 2. 11. 2016. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148680 . 10.1371/journal.pone.0148680 . published PLOS ONE
Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin
Naia, Luana; Ribeiro, Márcio; Rodrigues, Joana; Duarte, Ana I.; Lopes, Carla; Rosenstock, Tatiana R.; Hayden, Michael R.; Rego, A. Cristina, Neuropeptides. 73 - 81. 58. 2016. http://dx.doi.org/10.1016/j.npep.2016.01.009 . 10.1016/j.npep.2016.01.009 . published Neuropeptides
IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice
Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina, Molecular Neurobiology. 1126 - 1142. 3. 49. 2013. 10.1007/s12035-013-8585-5 . published Molecular Neurobiology
Peripheral and cerebral metabolic features in an animal model of Huntington's disease
Lopes, Carla Maria Nunes; Duarte, Ana I.; Hayden, Michael; Ana Cristina Carvalho Rego, IEEE Xplore Digital Library. 1 - 5. ,. 2012. http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6331390&isnumber=6331337 . 10.1109/ENBENG.2012.6331390 . published IEEE Xplore Digital Library
5 20 out of 20 Publications
All projects
Information of exclusive responsibility of the researcher 24-11-2024 , from platform CIÊNCIAVITAE.
2021/01/01 - 2025/12/31
Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31
Laboratório para a Investigação Integrativa e translacional em Saúde Populacional
LA/P/0064/2020
Universidade do Porto Instituto de Saúde Pública
Funders: Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31
CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2018/07/05 - 2021/07/04
iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Principal investigator
Centro de Neurociencias e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2018/07/05 - 2022/07/04
iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Principal investigator
Centro de Neurociencias e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2015 - 2017
Exploring the role of pridopidine on mitochondrial function and dynamics in Huntington's disease models
TEVA Pharmaceutical Industries
Post-doc
Centro de Neurociencias e Biologia Celular
Funders: Teva Pharmaceutical Industries Ltd
2015/12/01 - 2017/11/30
Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells
FLAD LIFE SCIENCE 2020
Post-doc Fellow
Centro de Neurociencias e Biologia Celular
Funders: Fundação Luso-Americana
2013 - 2018
Role of Sirtuin 3 on mitochondrial function and deacetylation of mitochondrial targets: relevance for Huntington's disease.
EXPL/BIM-MEC/2220/2013
Researcher
Centro de Neurociencias e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/11/01 - 2014/10/31
Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease
SFRH / BD / 51192 / 2010
PhD Student Fellow
Centro de Neurociencias e Biologia Celular; Universidade de Coimbra Instituto de Investigação Interdisciplinar
Funders: Fundação para a Ciencia e Tecnologia
2007/10 - 2008/05
AGES (Advanced Glycation End Products) and vascular complications in type 2 diabetes
GAPI Medical School
Other
Universidade de Coimbra Faculdade de Medicina
Funders: Universidade de Coimbra Faculdade de Medicina
5 10 out of 10 projects
We use cookies to improve your visit to our website.
