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Visão Geral

Filipa Baptista got her BSc degree in Biology in 2006 at the University of Coimbra (UC). In 2012 she completed her PhD in Biosciences (specialization in Cell and Molecular Biology at UC) focused on studying impact of diabetes on the central nervous system, elucidating diabetes-induced neuronal changes in diabetic encephalopathy and retinopathy. In 2013, Filipa Baptista got a postdoctoral position at the Center for Cell Biology, University of Aveiro (UA), aiming to develop novel therapeutic strategies to tackle Alzheimer´s disease (AD). But at the end of 2013, after a successful application to FCT postdoctoral grants, she decided to return to UC to carry out her project in the field of Diabetes. Simultaneously, she was a team member of Mantero Belard awarded project, and explored the concept of "the retina as a window to the brain" in AD, clarifying whether the retina can be used as tool for early AD diagnosis, contributed both with her knowledge in vision sciences and expertise in behavioral analysis to the study. In December 2018, Filipa Baptista got her present Researcher position at the Centre for Innovative Biomedicine and Biotechnology (CIBB) and is working on the field of Developmental programming, investigating how insults in critical periods of development underlie the emergence of disease later in life. Specifically, Filipa Baptista has been investigating the impact of maternal diabetes and prenatal stress on offspring brain investigating its putative long-term implications in cognitive impairment and psychiatric disorders. Filipa Baptista is also investigating putative sex differences in the clinical presentation of psychiatric disorders, opening new avenues for preventing neurodevelopmental changes or therapeutically intervene considering sex differences. Since 2019, FB is also an effective collaborator at Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), a leading institution of the UC, specialized in molecular imaging in Neuroscience and translational research. According to Scopus database Filipa Baptista is the author/coauthor of 39 papers in international peer reviewed journals, originating 1065 citations and an h-index of 18. As an important component of dissemination of research outputs, Filipa Baptista participated in several national and international meetings being an author/coauthor of more than 100 presentations (of which 45 were oral presentations). The total funding gathered from pharmaceutical companies and research programs surpasses 100 000 Euros, as co-Principal Investigator. Filipa Baptista is presently involved on the COST Action (CA22114) "Maternal Perinatal Stress and Adverse Outcomes in the Offspring", and was recently awarded with the best Project award (as PI) by the Portuguese Society of Diabetology (2023 ) on the area of Nutritional Psychiatry. Filipa Baptista frequently engage in outreaching activities, namely Brain Awareness Week, European Researcher´s Night and in several activities for high school students. FB was a member of the organizing committee of a symposium on Microglial cells (2014), the V Symposium of the Portuguese Glial Network (2021), and member of the organizing committee of the 5th CIBB Neuroscience Retreat (2023). Additionally, FB is responsible for the coordination of the weekly institutional Seminars where national and international researchers and clinicians are invited to share their work. FB has been invited as lecturer in several postgraduate courses, as Doctoral Programme in Health Sciences, Master´s in Biomedical Research, Master´s in Molecular and Translational Neuroscience and Integrated Master's in Medicine. FB supervision and training experience is mirrored in 1 PhD thesis (ongoing), 12 Master thesis (1 ongoing) and 30 undergraduate training and lab rotations.

Publicações

Informação sobre artigos em revista, actualizada a 27-04-2025, a partir da plataforma CIÊNCIAVITAE.

Stress in utero: prenatal dexamethasone exposure causes greater structural gliovascular alterations in female offspring than in males.

Ferreira-Rodrigues M; Sousa IS; Baptista FI; Coelho-Santos V, Frontiers in neuroscience. 2025. https://doi.org/10.3389/fnins.2025.1539867 . 10.3389/fnins.2025.1539867 . Frontiers in neuroscience

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches

Eliane Swely Sanches; Daniela Simões; Filipa Isabel Baptista; Ana Paula Silva, European Journal of Clinical Investigation. 2025. https://doi.org/10.1111/eci.14319 . 10.1111/eci.14319 . European Journal of Clinical Investigation

Tracing the influence of prenatal risk factors on the offspring retina: Focus on development and putative long-term consequences

Filipa I. Baptista; António F. Ambrósio, European Journal of Clinical Investigation. 2024. https://doi.org/10.1111/eci.14266 . 10.1111/eci.14266 . European Journal of Clinical Investigation

Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

Renato Socodato; Tiago O. Almeida; Camila C. Portugal; Evelyn C.S. Santos; Joana Tedim-Moreira; João Galvão-Ferreira; Teresa Canedo; et al, Cell Reports. 42. 2023. 10.1016/j.celrep.2023.113447 . Cell Reports

Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy.

Realinho AM; Boia R; Paiva B; Correia RG; Gaspar R; Ambrósio AF; Baptista FI, Life sciences. 2023. http://europepmc.org/abstract/med/37321535 . 10.1016/j.lfs.2023.121852 . Life sciences

Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes

Andreia Marreiros Amaro; Diana Sousa; Mariana Sá-Rocha; Marcos Divino Ferreira-Junior; Daniela Rosendo-Silva; Lucas Paulo Jacinto Saavedra; Cátia Barra; et al, Nutrients. 2023. https://www.mdpi.com/2072-6643/15/16/3581 . 10.3390/nu15163581 . Nutrients

Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes

Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos D.; Barra, Cátia; Monteiro, Tamaeh; Mathias, Paulo; et al, Life Sciences. 321. 2023. http://dx.doi.org/10.1016/j.lfs.2023.121597 . 10.1016/j.lfs.2023.121597 . Life Sciences

Neonatal testosterone voids sexually differentiated microglia morphology and behavior.

Simões-Henriques CF; Rodrigues-Neves AC; Sousa FJ; Gaspar R; Almeida I; Baptista FI; Ambrósio AF; Gomes CA, Frontiers in endocrinology. 2023. https://europepmc.org/articles/PMC10013065 . 10.3389/fendo.2023.1102068 . Frontiers in endocrinology

Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders

Amaro, Andreia; Baptista, Filipa I.; Matafome, Paulo, Life Sciences. 298. 2022. http://dx.doi.org/10.1016/j.lfs.2022.120526 . 10.1016/j.lfs.2022.120526 . Life Sciences

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António F.; Rodrigues, Ana João; Gomes, Catarina A., Frontiers in Behavioral Neuroscience. 16. 2022. http://dx.doi.org/10.3389/fnbeh.2022.834821 . 10.3389/fnbeh.2022.834821 . Frontiers in Behavioral Neuroscience

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Rita Gaspar; Carina Soares-Cunha; Ana Verónica Domingues; Bárbara Coimbra; Filipa I. Baptista; Luísa Pinto; António F. Ambrósio; Ana João Rodrigues; Catarina A. Gomes, Neurobiology of Stress. 100302 - 100302. 14. 2021. https://doi.org/10.1016/j.ynstr.2021.100302 . 10.1016/j.ynstr.2021.100302 . Neurobiology of Stress

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Rodrigues-Neves AC; Carecho R; Correia SC; Carvalho C; Campos EJ; Baptista FI; Moreira PI; Ambrósio AF, Molecular neurobiology. 2021. http://europepmc.org/abstract/med/33606195 . 10.1007/s12035-021-02316-x . Molecular neurobiology

Sex-specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress

Ana Sofia Ferreira; Sofia Galvão; Rita Gaspar; Ana C. Rodrigues-Neves; António F. Ambrósio; Paulo Matafome; Catarina A. Gomes; Filipa I. Baptista, European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13639 . 10.1111/eci.13639 . European Journal of Clinical Investigation

Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 Diabetes.

Baptista, FI, Brain research bulletin. 2020. https://doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain research bulletin

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.

Baptista, FI, Cell reports. 2020. https://doi.org/10.1016/j.celrep.2020.107796 . 10.1016/j.celrep.2020.107796 . Cell reports

Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: putative targets for insulin therapy

Sousa, Fábio J.; Correia, Raquel G.; Cruz, Alexandra F.; Martins, Joana M.; Rodrigues, Matilde S.; Gomes, Catarina A.; Ambrósio, António F.; Baptista, Filipa I., Brain, Behavior, & Immunity - Health. 2020. http://dx.doi.org/10.1016/j.bbih.2020.100075 . 10.1016/j.bbih.2020.100075 . accepted Brain, Behavior, & Immunity - Health

Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: brain region and sex specificities.

Baptista, FI, The European journal of neuroscience. 2019. https://doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . The European journal of neuroscience

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel.

Chiquita S; Rodrigues-Neves AC; Baptista FI; Carecho R; Moreira PI; Castelo-Branco M; Ambrósio AF, Molecular neurobiology. 2019. http://europepmc.org/abstract/med/30612332 . 10.1007/s12035-018-1461-6 . Molecular neurobiology

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss.

Chiquita S; Ribeiro M; Castelhano J; Oliveira F; Sereno J; Batista M; Abrunhosa A; et al, Human molecular genetics. 2019. http://europepmc.org/abstract/med/30816415 . 10.1093/hmg/ddz045 . Human molecular genetics

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons.

Pinheiro H; Gaspar R; Baptista FI; Fontes-Ribeiro CA; Ambrósio AF; Gomes CA, Frontiers in pharmacology. 2018. http://europepmc.org/abstract/med/29615903 . 10.3389/fphar.2018.00219 . Frontiers in pharmacology

Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.

Alves MRP; Boia R; Campos EJ; Martins J; Nunes S; Madeira MH; Santiago AR; et al, Molecular vision. 2018. http://europepmc.org/abstract/med/29853770 . Molecular vision

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies.

Baptista FI; Pinheiro H; Gomes CA; Ambrósio AF, Molecular neurobiology. 2018. http://europepmc.org/abstract/med/30003516 . 10.1007/s12035-018-1227-1 . Molecular neurobiology

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study.

Ribeiro M; Castelhano J; Petrella LI; Sereno J; Rodrigues T; Neves C; Letra L; et al, Journal of magnetic resonance imaging : JMRI. 2018. http://europepmc.org/abstract/med/29377412 . 10.1002/jmri.25942 . Journal of magnetic resonance imaging : JMRI

Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation

Filipa I. Baptista; Célia A. Aveleira; Áurea F. Castilho; António F. Ambrósio, Mediators of Inflammation. 2017. 10.1155/2017/4316316 . Mediators of Inflammation

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety.

Caetano L; Pinheiro H; Patrício P; Mateus-Pinheiro A; Alves ND; Coimbra B; Baptista FI; et al, 2016. http://europepmc.org/abstract/med/27725661 . 10.1038/mp.2016.173 .

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.

Baptista FI; Castilho ÁF; Gaspar JM; Liberal JT; Aveleira CA; Ambrósio AF, 2015. http://europepmc.org/abstract/med/26141610 . 10.1016/j.neulet.2015.06.044 .

Inside the diabetic brain: role of different players involved in cognitive decline.

Gaspar JM; Baptista FI; Macedo MP; Ambrosio AF, 2015. http://europepmc.org/abstract/med/26667832 .

Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina.

Castilho AF; Liberal JT; Baptista FI; Gaspar JM; Carvalho AL; Ambrósio AF, 2014. http://europepmc.org/abstract/med/24966661 .

Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.

Santiago AR; Baptista FI; Santos PF; Cristóvão G; Ambrósio AF; Cunha RA; Gomes CA, 2014. http://europepmc.org/abstract/med/25132733 . 10.1155/2014/465694 .

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.

Baptista FI; Pinto MJ; Elvas F; Martins T; Almeida RD; Ambrósio AF, 2014. http://europepmc.org/abstract/med/25064602 . 10.1016/j.exer.2014.07.011 .

Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer´s disease.

Baptista FI; Henriques AG; Silva AM; Wiltfang J; da Cruz E Silva OA, 2013. http://europepmc.org/abstract/med/24328060 .

Diabetes Alters KIF1A and KIF5B Motor Proteins in the Hippocampus

Baptista, F.I.; Pinto, M.J.; Elvas, F.; Almeida, R.D.; Ambrósio, A.F., PLoS ONE. 6. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878951512&partnerID=MN8TOARS . 10.1371/journal.pone.0065515 . PLoS ONE

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., Neuroscience. 23 - 32. 219. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity

Castilho, Á.F.; Aveleira, C.A.; Leal, E.C.; Simões, N.F.; Fernandes, C.R.; Meirinhos, R.I.; Baptista, F.I.; Ambrósio, A.F., PLoS ONE. 8. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864551111&partnerID=MN8TOARS . 10.1371/journal.pone.0042428 . PLoS ONE

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina

Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research

High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Aveleira, C.; Castilho, A.; Baptista, F.; Simões, N.; Fernandes, C.; Leal, E.; Ambrósio, A.F., Cytokine. 279 - 286. 3. 49. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75449089500&partnerID=MN8TOARS . 10.1016/j.cyto.2009.11.014 . Cytokine

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F., Neuroscience. 1589 - 1600. 4. 169. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.06.021 . Neuroscience

Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons

Gaspar, J.M.; Castilho, Á.; Baptista, F.I.; Liberal, J.; Ambrósio, A.F., Neuroscience. 981 - 992. 4. 171. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650169655&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.10.019 . Neuroscience

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina

Santiago, A.R.; Gaspar, J.M.; Baptista, F.I.; Cristóvão, A.J.; Santos, P.F.; Kamphuis, W.; Ambrósio, A.F., Molecular Vision. 1620 - 1630. 15. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949158370&partnerID=MN8TOARS . Molecular Vision

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, E.C.; Aveleira, C.A.; Castilho, A.F.; Serra, A.M.; Baptista, F.I.; Hosoya, K.-I.; Forrester, J.V.; Ambrósio, A.F., Experimental Eye Research. 983 - 991. 5. 88. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64849101327&partnerID=MN8TOARS . 10.1016/j.exer.2008.12.010 . Experimental Eye Research

Müller cells do not influence leukocyte adhesion to retinal endothelial cells

Leal, E.C.; Aveleira, C.A.; Castilho, A.F.; Baptista, F.I.; Ambrósio, A.F., Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049095985&partnerID=MN8TOARS . 10.1080/09273940802204535 . Ocular Immunology and Inflammation

Is the quantity of orbicules released by Dactylis glomerata and Cynosurus echinatus (Poaceae) big enough to play an allergenic role?

Baptista, Filipa, Grana. 2007. http://www.tandfonline.com/doi/abs/10.1080/00173130701448066#.UooLosS-2M5 . 10.1080/00173130701448066 . Grana

5 42 de 42 Publicações

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Informação da exclusiva responsabilidade do investigador 27-04-2025 , a partir da plataforma CIÊNCIAVITAE.

2023/07/01 - 2024/12/31

Tryptophan supplementation during pregnancy and lactation to improve cognition and metabolism in the offspring of diabetic mothers

Emílio Peres grant

Principal investigator

2022/01/01 - 2023/06/30

Mitochondria as potential drivers of sex-specific microglia dysfunctional remodelling and anxiety caused by prenatal stress

EXPL/MED-NEU/1002/2021

Other

Universidade de Coimbra

Financiadores: Fundação para a Ciência e a Tecnologia

2021/09 - 2023/12/31

Cerebrovascular hypothesis of stress-induced behavioral alterations

A-29178

Other

2019/07/01 - 2020/09

“Predictors of resistance to corticotherapy in children with nephrotic syndrome”

FMUC/Banco Santander-Totta; [PEPITA]2019: Programa de Estimulo a Projectos de Investigação Interdisciplinar e Translacional

Other

Universidade de Coimbra Faculdade de Medicina

2016/01/01 - 2018/12/31

“The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?”

Prémios Santa Casa Neurociências: Prémio Mantero Belard

Researcher

Santa Casa da Misericórdia de Lisboa

2013/10/01 - 2018/12/20

“Unravelling the involvement of neuroinflammation on the impairment of axonal transport in hippocampal neurons under diabetic conditions: contribution to synaptic changes and memory impairment”

SFRH/BPD/86830/2012

Post-doc Fellow

2013/02/01 - 2013/08/31

“New Strategies Applied to Neuropathological Disorders”

CENTRO-07-ST24-FEDER-002034

Post-doc Fellow

2008/01/01 - 2012/11/28

Impact of diabetes on exocytosis/neurotransmitter release in the retina

SFRH/BD/35961/2007

PhD Student Fellow

Financiadores: Fundação para a Ciência e a Tecnologia

5 8 de 8 projetos

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Filipa Baptista

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Visão Geral

Publicações

Todos os projectos