Shiva Tyagarajan

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

Andreadou, M.; Ingelfinger, F.; De Feo, D.; Cramer, T.L.M.; Tuzlak, S.; Friebel, E.; Schreiner, B.; et al, Nature Neuroscience. 1701 - 1712. 10. 26. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85172702206&partnerID=MN8TOARS . 10.1038/s41593-023-01435-z . Nature Neuroscience

Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function

Cramer, T.M.L.; Pinan-Lucarre, B.; Cavaccini, A.; Damilou, A.; Tsai, Y.-C.; Bhat, M.A.; Panzanelli, P.; et al, Cell Reports. 8. 42. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167441406&partnerID=MN8TOARS . 10.1016/j.celrep.2023.112947 . Cell Reports

Author Correction: A genetically encoded sensor for in vivo imaging of orexin neuropeptides (Nature Methods, (2022), 19, 2, (231-241), 10.1038/s41592-021-01390-2)

Duffet, L.; Kosar, S.; Panniello, M.; Viberti, B.; Bracey, E.; Zych, A.D.; Radoux-Mergault, A.; et al, Nature Methods. 505 - 505. 4. 19. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127421246&partnerID=MN8TOARS . 10.1038/s41592-022-01449-8 . Nature Methods

Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold

Thirouin, Z.S.; Figueiredo, M.; Hleihil, M.; Gill, R.; Bosshard, G.; McKinney, R.A.; Tyagarajan, S.K., Journal of Biological Chemistry. 5. 298. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85129194970&partnerID=MN8TOARS . 10.1016/j.jbc.2022.101840 . Journal of Biological Chemistry

Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

Olejniczak, I.; Campbell, B.; Tsai, Y.-C.; Tyagarajan, S.K.; Albrecht, U.; Ripperger, J.A., Frontiers in Physiology. 13. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140908566&partnerID=MN8TOARS . 10.3389/fphys.2022.909795 . Frontiers in Physiology

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

Campbell, B.F.N.; Dittmann, A.; Dreier, B.; Plückthun, A.; Tyagarajan, S.K., eLife. 11. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85141511865&partnerID=MN8TOARS . 10.1101/2022.06.30.498253 . eLife

Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia

Cramer, T.; Gill, R.; Thirouin, Z.S.; Vaas, M.; Sampath, S.; Martineau, F.; Noya, S.B.; et al, Science Advances. 9. 8. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125797047&partnerID=MN8TOARS . 10.1126/sciadv.abj0112 . Science Advances

A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Duffet, L.; Kosar, S.; Panniello, M.; Viberti, B.; Bracey, E.; Zych, A.D.; Radoux-Mergault, A.; et al, Nature Methods. 231 - 241. 2. 19. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124446137&partnerID=MN8TOARS . 10.1038/s41592-021-01390-2 . Nature Methods

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, F.; Zappettini, S.; Pressey, J.C.; Silva, C.G.; Russeau, M.; Gervasi, N.; Figueiredo, M.; et al, Science. 6568. 374. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118868990&partnerID=MN8TOARS . 10.1126/science.abk2055 . Science

Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity (Nature Communications, (2020), 11, 1, (4990), 10.1038/s41467-020-18494-6)

van Oostrum, M.; Campbell, B.; Seng, C.; Müller, M.; Dieck, S.; Hammer, J.; Pedrioli, P.G.A.; et al, Nature Communications. 1. 11. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095258614&partnerID=MN8TOARS . 10.1038/s41467-020-19654-4 . Nature Communications

Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

van Oostrum, M.; Campbell, B.; Seng, C.; Müller, M.; tom Dieck, S.; Hammer, J.; Pedrioli, P.G.A.; et al, Nature Communications. 1. 11. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091988569&partnerID=MN8TOARS . 10.1038/s41467-020-18494-6 . Nature Communications

Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

Brüning, F.; Noya, S.B.; Bange, T.; Koutsouli, S.; Rudolph, J.D.; Tyagarajan, S.K.; Cox, J.; et al, Science. 6462. 366. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073116489&partnerID=MN8TOARS . 10.1126/science.aav3617 . Science

Threat memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity

Bach, D.R.; Näf, M.; Deutschmann, M.; Tyagarajan, S.K.; Quednow, B.B., Journal of Neuroscience. 9424 - 9434. 47. 39. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075813847&partnerID=MN8TOARS . 10.1523/JNEUROSCI.1285-19.2019 . Journal of Neuroscience

Extracellular matrix: A new player in memory maintenance and psychiatric disorders

Bach, D.R.; Brown, S.A.; Kleim, B.; Tyagarajan, S.K., Swiss Medical Weekly. 21-22. 149. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067100398&partnerID=MN8TOARS . 10.4414/smw.2019.20060 . Swiss Medical Weekly

Cellular Mechanisms Contributing to the Functional Heterogeneity of GABAergic Synapses

Campbell, B.F.N.; Tyagarajan, S.K., Frontiers in Molecular Neuroscience. 12. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072724437&partnerID=MN8TOARS . 10.3389/fnmol.2019.00187 . Frontiers in Molecular Neuroscience

The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

Noya, S.B.; Colameo, D.; Brüning, F.; Spinnler, A.; Mircsof, D.; Opitz, L.; Mann, M.; et al, Science. 6462. 366. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073111002&partnerID=MN8TOARS . 10.1126/science.aav2642 . Science

The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures

Früh, S.; Tyagarajan, S.K.; Campbell, B.; Bosshard, G.; Fritschy, J.-M., Journal of Neurochemistry. 477 - 494. 4. 147. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056107767&partnerID=MN8TOARS . 10.1111/jnc.14572 . Journal of Neurochemistry

Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex

Virtanen, M.A.; Lacoh, C.M.; Fiumelli, H.; Kosel, M.; Tyagarajan, S.; de Roo, M.; Vutskits, L., Brain Structure and Function. 1999 - 2012. 4. 223. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040374303&partnerID=MN8TOARS . 10.1007/s00429-017-1602-0 . Brain Structure and Function

Activity-dependent inhibitory synapse scaling is determined by gephyrin phosphorylation and subsequent regulation of GABA_A receptor diffusion

Battaglia, S.; Renner, M.; Russeau, M.; Côme, E.; Tyagarajan, S.K.; Lévi, S., eNeuro. 1. 5. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041006623&partnerID=MN8TOARS . 10.1523/ENEURO.0203-17.2017 . eNeuro

Nanoscale molecular reorganization of the inhibitory postsynaptic density is a determinant of gabaergic synaptic potentiation

Pennacchietti, F.; Vascon, S.; Nieus, T.; Rosillo, C.; Das, S.; Tyagarajan, S.K.; Diaspro, A.; et al, Journal of Neuroscience. 1747 - 1756. 7. 37. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013074751&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0514-16.2016 . Journal of Neuroscience

Commentary: Analysis of SUMO1-conjugation at synapses

Wilkinson, K.A.; Martin, S.; Tyagarajan, S.K.; Arancio, O.; Craig, T.J.; Guo, C.; Fraser, P.E.; Goldstein, S.A.N.; Henley, J.M., Frontiers in Cellular Neuroscience. 11. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044562300&partnerID=MN8TOARS . 10.3389/fncel.2017.00345 . Frontiers in Cellular Neuroscience

GABAergic Synaptogenesis: A Case for Cooperation

Fritschy, J.-M.; Tyagarajan, S.K., Neuron. 709 - 711. 4. 96. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033699435&partnerID=MN8TOARS . 10.1016/j.neuron.2017.11.003 . Neuron

Emerging mechanisms underlying dynamics of GABAergic synapses

Maffei, A.; Charrier, C.; Caiati, M.D.; Barberis, A.; Mahadevan, V.; Woodin, M.A.; Tyagarajan, S.K., Journal of Neuroscience. 10792 - 10799. 45. 37. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033576909&partnerID=MN8TOARS . 10.1523/JNEUROSCI.1824-17.2017 . Journal of Neuroscience

Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABA_A receptors at inhibitory synapses

Mukherjee, J.; Cardarelli, R.A.; Cantaut-Belarif, Y.; Deeb, T.Z.; Srivastava, D.P.; Tyagarajan, S.K.; Pangalos, M.N.; et al, Proceedings of the National Academy of Sciences of the United States of America. 11763 - 11768. 44. 114. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032741283&partnerID=MN8TOARS . 10.1073/pnas.1705075114 . Proceedings of the National Academy of Sciences of the United States of America

Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells

Früh, Simon; Romanos, Jennifer; Panzanelli, Patrizia; Bürgisser, Daniela; Tyagarajan, Shiva K.; Campbell, Kevin P.; Santello, Mirko; Fritschy, Jean-Marc, The Journal of Neuroscience. 10296 - 10313. 40. 36. 2016. https://doi.org/10.1523/jneurosci.1823-16.2016 . 10.1523/jneurosci.1823-16.2016 . The Journal of Neuroscience

Partial inactivation of GABA_A receptors containing the a5 subunit affects the development of adult-born dentate gyrus granule cells

Deprez, F.; Vogt, F.; Floriou-Servou, A.; Lafourcade, C.; Rudolph, U.; Tyagarajan, S.K.; Fritschy, J.-M., European Journal of Neuroscience. 2258 - 2271. 5. 44. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84985963127&partnerID=MN8TOARS . 10.1111/ejn.13329 . European Journal of Neuroscience

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

Ghosh, Himanish; Auguadri, Luca; Battaglia, Sereina; Simone Thirouin, Zahra; Zemoura, Khaled; Messner, Simon; Acuña, Mario A.; et al, Nature Communications. 1. 7. 2016. https://doi.org/10.1038/ncomms13365 . 10.1038/ncomms13365 . Nature Communications

Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.

PNAS. 2015. http://www.ncbi.nlm.nih.gov/pubmed/25535349 . PNAS

Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb

Deprez, F.; Pallotto, M.; Vogt, F.; Grabiec, M.; Virtanen, M.A.; Tyagarajan, S.K.; Panzanelli, P.; Fritschy, J.-M., Journal of Comparative Neurology. 1998 - 2016. 13. 523. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937231976&partnerID=MN8TOARS . 10.1002/cne.23776 . Journal of Comparative Neurology

Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects

Mircsof, D.; Langouët, M.; Rio, M.; Moutton, S.; Siquier-Pernet, K.; Bole-Feysot, C.; Cagnard, N.; et al, Nature Neuroscience. 1731 - 1736. 12. 18. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949132230&partnerID=MN8TOARS . 10.1038/nn.4169 . Nature Neuroscience

Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation

Flores, C.E.; Nikonenko, I.; Mendez, P.; Fritschy, J.-M.; Tyagarajan, S.K.; Muller, D., Proceedings of the National Academy of Sciences of the United States of America. E65 - E72. 1. 112. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920426339&partnerID=MN8TOARS . 10.1073/pnas.1411170112 . Proceedings of the National Academy of Sciences of the United States of America

Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment

Lueke, K.; Kaiser, T.; Svetlitchny, A.; Welzel, O.; Wenzel, E.M.; Tyagarajan, S.; Kornhuber, J.; Groemer, T.W., Journal of Neural Transmission. 211 - 219. 2. 121. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893798095&partnerID=MN8TOARS . 10.1007/s00702-013-1087-9 . Journal of Neural Transmission

Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission

Accardi, M.V.; Daniels, B.A.; Brown, P.M.G.E.; Fritschy, J.-M.; Tyagarajan, S.K.; Bowie, D., Nature Communications. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892690009&partnerID=MN8TOARS . 10.1038/ncomms4168 . Nature Communications

Gephyrin: A master regulator of neuronal function?

Tyagarajan, S.K.; Fritschy, J.-M., Nature Reviews Neuroscience. 141 - 156. 3. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897874869&partnerID=MN8TOARS . 10.1038/nrn3670 . Nature Reviews Neuroscience

Extracellular signal-regulated kinase and glycogen synthase kinase 3ß regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism

Tyagarajan, S.K.; Ghosh, H.; Yévenes, G.E.; Imanishi, S.Y.; Zeilhofer, H.U.; Gerrits, B.; Fritschy, J.-M., Journal of Biological Chemistry. 9634 - 9647. 14. 288. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876006492&partnerID=MN8TOARS . 10.1074/jbc.M112.442616 . Journal of Biological Chemistry

Molecular and functional heterogeneity of GABAergic synapses

Fritschy, J.-M.; Panzanelli, P.; Tyagarajan, S.K., Cellular and Molecular Life Sciences. 2485 - 2499. 15. 69. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864353034&partnerID=MN8TOARS . 10.1007/s00018-012-0926-4 . Cellular and Molecular Life Sciences

Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection

Farinelli, M.; Heitz, F.D.; Grewe, B.F.; Tyagarajan, S.K.; Helmchen, F.; Mansuy, I.M., PLoS ONE. 3. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859138345&partnerID=MN8TOARS . 10.1371/journal.pone.0034047 . PLoS ONE

Distinct mechanisms regulate GABA _A receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

Panzanelli, P.; Gunn, B.G.; Schlatter, M.C.; Benke, D.; Tyagarajan, S.K.; Scheiffele, P.; Belelli, D.; et al, Journal of Physiology. 4959 - 4980. 20. 589. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054099531&partnerID=MN8TOARS . 10.1113/jphysiol.2011.216028 . Journal of Physiology

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses

Tyagarajan, S.K.; Ghosh, H.; Harvey, K.; Fritschy, J.-M., Journal of Cell Science. 2786 - 2796. 16. 124. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961132249&partnerID=MN8TOARS . 10.1242/jcs.086199 . Journal of Cell Science

Regulation of GABAergic synapse formation and plasticity by GSK3ß-dependent phosphorylation of gephyrin

Tyagarajan, S.K.; Ghosh, H.; Yévenes, G.E.; Nikonenko, I.; Ebeling, C.; Schwerdel, C.; Sidler, C.; et al, Proceedings of the National Academy of Sciences of the United States of America. 379 - 384. 1. 108. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651103907&partnerID=MN8TOARS . 10.1073/pnas.1011824108 . Proceedings of the National Academy of Sciences of the United States of America

GABA_A receptors, gephyrin and homeostatic synaptic plasticity

Tyagarajan, S.K.; Fritschy, J.-M., Journal of Physiology. 101 - 106. 1. 588. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549114248&partnerID=MN8TOARS . 10.1113/jphysiol.2009.178517 . Journal of Physiology

Stability and function of JC viras large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues

Tyagarajan, S.K.; Frisque, R.J., Journal of Virology. 2083 - 2091. 5. 80. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144483491&partnerID=MN8TOARS . 10.1128/JVI.80.5.2083-2091.2006 . Journal of Virology

Transforming activities of JC virus early proteins.

Frisque RJ; Hofstetter C; Tyagarajan SK, 2006. http://europepmc.org/abstract/med/16626044 .

JC virus T'₁₃₅, T'₁₃₆ and T'₁₆₅ proteins interact with cellular p107 and p130 in vivo and influence viral transformation potential

Bollag, B.; Kilpatrick, L.H.; Tyagarajan, S.K.; Tevethia, M.J.; Frisque, R.J., Journal of NeuroVirology. 428 - 442. 6. 12. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845489472&partnerID=MN8TOARS . 10.1080/13550280601009553 . Journal of NeuroVirology

The stability and function of JC virus tumor proteins are influenced by mutations to amino acid residue threonine 125

Tyagarajan, Shiva K.; Frisque, Richard J., Journal of Neurovirology. 43 - 43. 14. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415200026&KeyUID=WOS:000205415200026 . Journal of Neurovirology

T antigen isoforms of the human polyomaviruses

Frisque, Richard J.; Bam, Rujuta; Tyagarajan, Shiva K.; Tevethia, M. Judith, Journal of Neurovirology. 65 - 65. 14. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415200048&KeyUID=WOS:000205415200048 . Journal of Neurovirology

JC virus early proteins: Contributions to virus-host interactions

Frisque, R. J.; Kilpatrick, L. H.; Tyagarajan, S. T., Journal of Neurovirology. 21 - 21. 14. 2004. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205415100014&KeyUID=WOS:000205415100014 . 10.1080/13550280490469653 . Journal of Neurovirology

T ' proteins influence JC virus biology

Frisque, RJ; Bollag, B; Tyagarajan, SK; Kilpatrick, LH, Journal of Neurovirology. 15 - 20. 9. 2003. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000182795700004&KeyUID=WOS:000182795700004 . 10.1080/713831425 . Journal of Neurovirology

T' proteins influence JC virus biology

Frisque, R.J.; Bollag, B.; Tyagarajan, S.K.; Kilpatrick, L.H., Journal of NeuroVirology. 15 - 30. SUPPL. 1. 9. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144441436&partnerID=MN8TOARS . Journal of NeuroVirology

T' proteins influence JC virus biology.

Frisque RJ; Bollag B; Tyagarajan SK; Kilpatrick LH, 2003. http://europepmc.org/abstract/med/12709866 .