Biotecnologia

Biologia de Sistemas e Computacional

Modelação Computacional e Matemática

Biologia Redox

Membranas Biológicas

Metabolismo

Biologia de Sistemas

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Líder

Armindo Salvador

Investigador(a)


Linhas de interesse

Relação entre o design e a função na sinalização redox e proteção antioxidante

Modelação da permeabilidade através de barreiras fisiológicas

Ferramentas computacionais para sistemas biomoleculares


Publicações

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Informação sobre artigos em revista, actualizada a 15-05-2022, a partir da plataforma CIÊNCIAVITAE.

Calculation of Permeability Coefficients from Solute Equilibration Dynamics: An Assessment of Various Methods

Margarida M. Cordeiro; Armindo Salvador; Maria João Moreno, 2022. Membranes. 254 - 254. 3. 12. 2022. https://doi.org/10.3390/membranes12030254 . 10.3390/membranes12030254 . Membranes

In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity

A. Ledo; E. Fernandes; A. Salvador; J. Laranjinha; R.M. Barbosa, 2022. Redox Biology. 50. 2022. https://doi.org/10.1016/j.redox.2022.102250 . 10.1016/j.redox.2022.102250 . published Redox Biology

Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2

Peskin, Alexander V.; Meotti, Flávia C.; de Souza, Luiz F.; Anderson, Robert F.; Winterbourn, Christine C.; Salvador, Armindo, 2020. Free Radical Biology and Medicine. 115 - 125. 158. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2020.07.007 . 10.1016/j.freeradbiomed.2020.07.007 . published Free Radical Biology and Medicine

Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations—Translocation of Cholesterol across Lipid Bilayers

Filipe, Hugo A. L.; Javanainen, Matti; Salvador, Armindo; Galvão, Adelino M.; Vattulainen, Ilpo; Loura, Luís M. S.; Moreno, Maria João, 2018. Journal of Chemical Theory and Computation. 3840 - 3848. 7. 14. 2018. http://dx.doi.org/10.1021/acs.jctc.8b00150 . 10.1021/acs.jctc.8b00150 . published Journal of Chemical Theory and Computation

Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types

Selvaggio, Gianluca; Coelho, Pedro M.B.M.; Salvador, Armindo, 2018. Redox Biology. 297 - 315. 15. 2018. http://dx.doi.org/10.1016/j.redox.2017.12.008 . 10.1016/j.redox.2017.12.008 . published Redox Biology

Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling

Travasso, R.D.M.; Sampaio dos Aidos, F.; Bayani, A.; Abranches, P.; Salvador, A., 2017. Redox Biology. 233 - 245. 12. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014574052&partnerID=MN8TOARS . 10.1016/j.redox.2017.01.003 . published Redox Biology

Mass Isotopomer Analysis of Nucleosides Isolated from RNA and DNA Using GC/MS

Miranda-Santos, Ines; Gramacho, Silvia; Pineiro, Marta; Martinez-Gomez, Karla; Fritz, Michel; Hollemeyer, Klaus; Salvador, Armindo; Heinzle, Elmar, 2015. Analytical Chemistry. 617 - 623. 1. 87. 2015. https://doi.org/10.1021/ac503305w . 10.1021/ac503305w . published Analytical Chemistry

Beyond Overton's Rule: Quantitative Modeling of Passive Permeation through Tight Cell Monolayers

Filipe, H. A. L.; Salvador, A.; Silvestre, J. M.; Vaz, W. L. C.; Moreno, M. J., 2014. Molecular Pharmaceutics. 3696 - 3706. 10. 11. 2014. http://dx.doi.org/10.1021/mp500437e . 10.1021/mp500437e . published Molecular Pharmaceutics

Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport

Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C., 2014. Journal of Lipid Research. 1033 - 1043. 6. 55. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS . 10.1194/jlr.M043067 . published Journal of Lipid Research

Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II

Benfeitas, R.; Selvaggio, G.; Antunes, F.; Coelho, P.M.B.M.; Salvador, A., 2014. Free Radical Biology and Medicine. 35 - 49. 74. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904329372&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2014.06.007 . published Free Radical Biology and Medicine

Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes

Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A., 2010. PLoS ONE. 9. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958545833&partnerID=MN8TOARS . 10.1371/journal.pone.0013031 . published PLoS ONE

Quantifying global tolerance of biochemical systems: Design implications for moiety-transfer cycles

Coelho, P.M.B.M.; Salvador, A.; Savageau, M.A., 2009. PLoS Computational Biology. 3. 5. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549119474&partnerID=MN8TOARS . 10.1371/journal.pcbi.1000319 . published PLoS Computational Biology

Phenotypes and tolerances in the design space of biochemical systems

Savageau, M.A.; Coelho, P.M.B.M.; Fasani, R.A.; Tolla, D.A.; Salvador, A., 2009. Proceedings of the National Academy of Sciences of the United States of America. 6435 - 6440. 16. 106. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108427&partnerID=MN8TOARS . 10.1073/pnas.0809869106 . published Proceedings of the National Academy of Sciences of the United States of America

Tools for kinetic modeling of biochemical networks

Alves, R.; Antunes, F.; Salvador, A., 2006. Nature Biotechnology. 667 - 672. 6. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745075591&partnerID=MN8TOARS . 10.1038/nbt0606-667 . published Nature Biotechnology

Evolution of enzymes in a series is driven by dissimilar functional demands

Salvador, A.; Savageau, M.A., 2006. Proceedings of the National Academy of Sciences of the United States of America. 2226 - 2231. 7. 103. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144458377&partnerID=MN8TOARS . 10.1073/pnas.0510776103 . published Proceedings of the National Academy of Sciences of the United States of America

Why does superoxide dismutase overexpression often increase hydrogen peroxide concentrations? An alternative explanation

Gardner, R.; Moradas-Ferreira, P.; Salvador, A., 2006. Journal of Theoretical Biology. 798 - 800. 3. 242. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747879504&partnerID=MN8TOARS . 10.1016/j.jtbi.2006.04.007 . published Journal of Theoretical Biology

Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes

Salvador, A.; Savageau, M.A., 2003. Proceedings of the National Academy of Sciences of the United States of America. 14463 - 14468. SUPPL. 2. 100. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345060788&partnerID=MN8TOARS . 10.1073/pnas.2335687100 . published Proceedings of the National Academy of Sciences of the United States of America

Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation

Gardner, R.; Salvador, A.; Moradas-Ferreira, P., 2002. Free Radical Biology and Medicine. 1351 - 1357. 12. 32. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037096203&partnerID=MN8TOARS . 10.1016/S0891-5849(02)00861-4 . published Free Radical Biology and Medicine

Hydroperoxyl, superoxide and pH gradients in the mitochondrial matrix: A theoretical assessment

Salvador, A.; Sousa, J.; Pinto, R.E., 2001. Free Radical Biology and Medicine. 1208 - 1215. 10. 31. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035890104&partnerID=MN8TOARS . 10.1016/S0891-5849(01)00707-9 . published Free Radical Biology and Medicine

Synergism analysis of biochemical systems. II. Tensor formulation and treatment of stoichiometric constraints

Salvador, A., 2000. Mathematical Biosciences. 131 - 158. 2. 163. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034092624&partnerID=MN8TOARS . 10.1016/S0025-5564(99)00057-7 . published Mathematical Biosciences

Synergism analysis of biochemical systems. I. Conceptual framework

Salvador, A., 2000. Mathematical Biosciences. 105 - 129. 2. 163. 2000. 10.1016/s0025-5564(99)00056-5 . published Mathematical Biosciences

Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model

Antunes, F.; Salvador, A.; Marinho, H.S.; Alves, R.; Pinto, R.E., 1996. Free Radical Biology and Medicine. 917 - 943. 7. 21. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029908304&partnerID=MN8TOARS . 10.1016/S0891-5849(96)00185-2 . published Free Radical Biology and Medicine

PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria

Antunes, F.; Salvador, A.; Pinto, R.E., 1995. Free Radical Biology and Medicine. 669 - 677. 5. 19. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028991435&partnerID=MN8TOARS . 10.1016/0891-5849(95)00040-5 . published Free Radical Biology and Medicine

Kinetic modelling of in vitro lipid peroxidation experiments--'low level' validation of a model of in vivo lipid peroxidation.

Salvador, A.; Antunes, F.; Pinto, R.E., 1995. Free radical research. 151 - 172. 2. 23. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029355440&partnerID=MN8TOARS . 10.3109/10715769509064029 . published Free radical research

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