Micro-ambiente Tumoral e Terapias Direcionadas

New advances in exosome-based targeted drug delivery systems

Ferreira, Débora; Moreira, João Nuno; Rodrigues, Lígia R., 2022. Critical Reviews in Oncology/Hematology. 172. 2022. http://dx.doi.org/10.1016/j.critrevonc.2022.103628 . 10.1016/j.critrevonc.2022.103628 . Critical Reviews in Oncology/Hematology

Editorial—Current Insights on Lipid-Based Nanosystems

Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo, 2022. Pharmaceuticals. 2022. https://doi.org/10.3390/ph15101267 . 10.3390/ph15101267 . Pharmaceuticals

Nucleolin expression has prognostic value in neuroblastoma patients

Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Giusto, Elena; et al, 2022. eBioMedicine. 85. 2022. http://dx.doi.org/10.1016/j.ebiom.2022.104300 . 10.1016/j.ebiom.2022.104300 . eBioMedicine

Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma

Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno (EF1B-FA3D-0787); Soares, Helena; Corvo, M. Luisa; Cruz, Maria Eugénia M., 2022. International Journal of Pharmaceutics. 612. 2022. http://dx.doi.org/10.1016/j.ijpharm.2021.121380 . 10.1016/j.ijpharm.2021.121380 . International Journal of Pharmaceutics

Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities

Ribeiro, Rita; Carvalho, Maria João; Goncalves, João; Moreira, João Nuno, 2022. Frontiers in Molecular Biosciences. 9. 2022. http://dx.doi.org/10.3389/fmolb.2022.903065 . 10.3389/fmolb.2022.903065 . published Frontiers in Molecular Biosciences

Abstract 1276: Nucleolin has prognostic value in neuroblastoma patients

Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Calarco, Enzo; et al, 2022. Cancer Research. 1276 - 1276. 12_Supplem. 82. 2022. http://dx.doi.org/10.1158/1538-7445.am2022-1276 . 10.1158/1538-7445.am2022-1276 . Cancer Research

Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders

Correia, A.C.; Monteiro, A.R.; Silva, R.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A.C., 2022. Advanced Drug Delivery Reviews. 189. 2022. http://dx.doi.org/10.1016/j.addr.2022.114485 . 10.1016/j.addr.2022.114485 . Advanced Drug Delivery Reviews

Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature of drug interaction beyond bulk tumor cells

Cruz, Ana Filipa; Fonseca, Nuno A.; Malheiro, Ana Rita; B. Melo, Joana; Gaspar, Maria Manuela; Fernandes, Rui; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2022. European Journal of Pharmaceutics and Biopharmaceutics. 61 - 77. 172. 2022. http://dx.doi.org/10.1016/j.ejpb.2022.01.006 . 10.1016/j.ejpb.2022.01.006 . European Journal of Pharmaceutics and Biopharmaceutics

Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer

Valério-Fernandes, Ângela; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; et al, 2022. Cancers. 9. 14. 2022. http://dx.doi.org/10.3390/cancers14092217 . 10.3390/cancers14092217 . Cancers

Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis

Carvalho, Laura Sofia; Gonçalves, Nélio; Fonseca, Nuno André; Moreira, João Nuno, 2021. Pharmaceuticals. 1. 14. 2021. http://dx.doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

Cláudia Pina Costa; João Nuno Moreira; José Manuel Sousa Lobo; Ana Catarina Silva, 2021. Acta Pharmaceutica Sinica B. 2021. https://doi.org/10.1016/j.apsb.2021.02.012 . 10.1016/j.apsb.2021.02.012 . Acta Pharmaceutica Sinica B

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Simões, Sérgio; Moreira, João Nuno, 2021. Nano Today. 37. 2021. http://dx.doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: toxicological effect of surface charge on human neuronal cells

Costa, C.P.; Cunha, S.; Moreira, J. N.; Silva, R.; Gil-Martins, E.; Silva, V.; Azevedo, L.; et al, 2021. International Journal of Pharmaceutics. 2021. http://dx.doi.org/10.1016/j.ijpharm.2021.120933 . 10.1016/j.ijpharm.2021.120933 . International Journal of Pharmaceutics

Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy

Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A.; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F.; Malaguti, Fabiana; et al, 2021. Journal of Experimental & Clinical Cancer Research. 1. 40. 2021. http://dx.doi.org/10.1186/s13046-021-01993-9 . 10.1186/s13046-021-01993-9 . Journal of Experimental & Clinical Cancer Research

Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin

Rui Lopes; Kevin Shi; Nuno A. Fonseca; Adelina Gama; José S. Ramalho; Luís Almeida; Vera Moura; et al, 2021. Drug Delivery and Translational Research. 2021. https://doi.org/10.1007/s13346-021-00972-z . 10.1007/s13346-021-00972-z . Drug Delivery and Translational Research

The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Ana Filipa Fernandes da Cruz; Mariana Biscaia Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, 2021. Cancers. 2021. https://www.mdpi.com/2072-6694/13/12/3052 . 10.3390/cancers13123052 . Cancers

In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN)

Cláudia Pina Costa; Sandra Barreiro; João Nuno Moreira; Renata Silva; Hugo Almeida; José Manuel Sousa Lobo; Ana Catarina Silva, 2021. Pharmaceuticals. 711 - 711. 8. 14. 2021. https://doi.org/10.3390/ph14080711 . 10.3390/ph14080711 . Pharmaceuticals

Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review

Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C., 2020. Nanomedicine: Nanotechnology, Biology and Medicine. 2020. http://dx.doi.org/10.1016/j.nano.2020.102206 . 10.1016/j.nano.2020.102206 . in press Nanomedicine: Nanotechnology, Biology and Medicine

Application of the Quality-by-Design (QbD) Approach to Improve the Nose-to-Brain Delivery of Diazepam-Loaded Nanostructured Lipid Carriers (NLCs)

Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana Catarina, 2020. Proceedings. 1. 78. 2020. http://dx.doi.org/10.3390/iecp2020-08658 . 10.3390/iecp2020-08658 . Proceedings

Current challenges and emerging opportunities of CAR-T cell therapies

Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno (EF1B-FA3D-0787), 2020. Journal of Controlled Release. 246 - 261. 319. 2020. http://dx.doi.org/10.1016/j.jconrel.2019.12.047 . 10.1016/j.jconrel.2019.12.047 . Journal of Controlled Release

Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis

Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C., 2019. Journal of Controlled Release. 187 - 200. 295. 2019. http://dx.doi.org/10.1016/j.jconrel.2018.12.049 . 10.1016/j.jconrel.2018.12.049 . published Journal of Controlled Release

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

Romano, Sofia; Fonseca, Nuno; Simões, Sérgio; Gonçalves, João; Moreira, João Nuno, 2019. Drug Discovery Today. 1985 - 2001. 10. 24. 2019. http://dx.doi.org/10.1016/j.drudis.2019.06.018 . 10.1016/j.drudis.2019.06.018 . published Drug Discovery Today

Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles

Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno, 2018. Current Pharmaceutical Design. 6563 - 6572. 43. 23. 2018. http://dx.doi.org/10.2174/1381612823666171115105252 . 10.2174/1381612823666171115105252 . Current Pharmaceutical Design

Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity

Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno, 2018. Experimental Cell Research. 68 - 77. 1. 370. 2018. http://dx.doi.org/10.1016/j.yexcr.2018.06.005 . 10.1016/j.yexcr.2018.06.005 . published Experimental Cell Research

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João, 2018. Scientific Reports. 1. 8. 2018. http://dx.doi.org/10.1038/s41598-018-25816-8 . 10.1038/s41598-018-25816-8 . Scientific Reports

Meeting the needs of breast cancer: A nucleolin's perspective

Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2018. Critical Reviews in Oncology/Hematology. 89 - 101. 125. 2018. http://dx.doi.org/10.1016/j.critrevonc.2018.03.008 . 10.1016/j.critrevonc.2018.03.008 . Critical Reviews in Oncology/Hematology

Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer

Zupancic, Eva; Curato, Caterina; Kim, Jung-Seok; Yeini, Eilam; Porat, Ziv; Viana, Ana S.; Globerson-Levin, Anat; et al, 2018. Nanomedicine: Nanotechnology, Biology and Medicine. 835 - 847. 3. 14. 2018. http://dx.doi.org/10.1016/j.nano.2017.12.011 . 10.1016/j.nano.2017.12.011 . Nanomedicine: Nanotechnology, Biology and Medicine

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer

Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório; et al, 2017. Pathology & Oncology Research. 701 - 716. 4. 24. 2017. http://dx.doi.org/10.1007/s12253-017-0307-2 . 10.1007/s12253-017-0307-2 . Pathology & Oncology Research

The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors

Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2017. Critical Reviews in Oncology/Hematology. 111 - 121. 113. 2017. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016 . 10.1016/j.critrevonc.2017.03.016 . Critical Reviews in Oncology/Hematology

Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming

Zupancic, Eva; Curato, Caterina; Paisana, Maria; Rodrigues, Catarina; Porat, Ziv; Viana, Ana S.; Moreira, João N.; et al, 2017. Journal of Controlled Release. 182 - 195. 258. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.05.014 . 10.1016/j.jconrel.2017.05.014 . Journal of Controlled Release

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Biomaterials. 124 - 137. 82. 2016. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021 . 10.1016/j.biomaterials.2015.12.021 . published Biomaterials

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2016. PLOS ONE. 11. 11. 2016. http://dx.doi.org/10.1371/journal.pone.0165817 . 10.1371/journal.pone.0165817 . PLOS ONE

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Data in Brief. 700 - 705. 6. 2016. http://dx.doi.org/10.1016/j.dib.2016.01.017 . 10.1016/j.dib.2016.01.017 . Data in Brief

Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome

Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al, 2016. RSC Advances. 114599 - 114612. 115. 6. 2016. https://doi.org/10.1039/C6RA21623D . 10.1039/C6RA21623D . RSC Advances

Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin

Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2015. Acta Biomaterialia. 196 - 205. 18. 2015. http://dx.doi.org/10.1016/j.actbio.2015.02.018 . 10.1016/j.actbio.2015.02.018 . Acta Biomaterialia

Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination

Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João Nuno, 2015. Biomaterials. 76 - 88. 69. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007 . 10.1016/j.biomaterials.2015.08.007 . published Biomaterials

Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines

Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena, 2015. Current Topics in Medicinal Chemistry. 291 - 313. 3. 16. 2015. http://dx.doi.org/10.2174/1568026615666150701115508 . 10.2174/1568026615666150701115508 . Current Topics in Medicinal Chemistry

Bridging cancer biology and the patients' needs with nanotechnology-based approaches

Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N., 2014. Cancer Treatment Reviews. 626 - 635. 5. 40. 2014. http://dx.doi.org/10.1016/j.ctrv.2014.02.002 . 10.1016/j.ctrv.2014.02.002 . published Cancer Treatment Reviews

Development of a Novel Nanoparticle-based Therapeutic Vaccine for Breast Cancer Immunotherapy

Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F., 2014. Procedia in Vaccinology. 62 - 67. 8. 2014. http://dx.doi.org/10.1016/j.provac.2014.07.011 . 10.1016/j.provac.2014.07.011 . published Procedia in Vaccinology

Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering

Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. Biomater. Sci.. 1195 - 1209. 9. 2. 2014. http://dx.doi.org/10.1039/c4bm00069b . 10.1039/c4bm00069b . published Biomater. Sci.

Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination

Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2014. Journal of Controlled Release. 122 - 131. 196. 2014. http://dx.doi.org/10.1016/j.jconrel.2014.09.024 . 10.1016/j.jconrel.2014.09.024 . Journal of Controlled Release

Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering

Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. ACS Nano. 8082 - 8094. 8. 8. 2014. http://dx.doi.org/10.1021/nn5021049 . 10.1021/nn5021049 . published ACS Nano

Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells

Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2013. European Journal of Pharmaceutics and Biopharmaceutics. 356 - 364. 3. 85. 2013. http://dx.doi.org/10.1016/j.ejpb.2013.04.007 . 10.1016/j.ejpb.2013.04.007 . published European Journal of Pharmaceutics and Biopharmaceutics

Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin

Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N., 2013. Current Gene Therapy. 189 - 201. 3. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS . 10.2174/1566523211313030004 . Current Gene Therapy

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões, Sérgio; Moreira, João N, 2013. Nanomedicine. 1397 - 1413. 9. 8. 2013. http://dx.doi.org/10.2217/nnm.12.174 . 10.2217/nnm.12.174 . published Nanomedicine

MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent

Figueiredo, S.; Cutrin, J.C.; Rizzitelli, S.; De Luca, E.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2013. Molecular Imaging and Biology. 307 - 315. 3. 15. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727777&partnerID=MN8TOARS . 10.1007/s11307-012-0603-x . Molecular Imaging and Biology

On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human mesenchymal stem cells

Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.; Moreira, João Nuno, 2013. Journal of Tissue Engineering and Regenerative Medicine. 1056 - 1066. 9. 9. 2013. http://dx.doi.org/10.1002/term.1817 . 10.1002/term.1817 . published Journal of Tissue Engineering and Regenerative Medicine

Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment

Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N; Pereira de Almeida, Luís; Pedroso de Lima, Maria C, 2013. Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 . 10.1038/mtna.2013.30 . published Molecular Therapy - Nucleic Acids

Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N., 2013. Cellular and Molecular Life Sciences. 1417 - 1438. 8. 71. 2013. http://dx.doi.org/10.1007/s00018-013-1502-2 . 10.1007/s00018-013-1502-2 . published Cellular and Molecular Life Sciences

Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations

Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2012. Journal of Nanoscience and Nanotechnology. 2891 - 2900. 3. 12. 2012. http://dx.doi.org/10.1166/jnn.2012.5703 . 10.1166/jnn.2012.5703 . Journal of Nanoscience and Nanotechnology

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. Accounts of Chemical Research. 1163 - 1171. 7. 45. 2012. http://dx.doi.org/10.1021/ar300048p . 10.1021/ar300048p . published Accounts of Chemical Research

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. International Journal of Pharmaceutics. 9 - 19. 1-2. 434. 2012. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018 . 10.1016/j.ijpharm.2012.05.018 . published International Journal of Pharmaceutics

[Visualization of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]

Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E., 2011. Revista Portuguesa de Pneumologia (English Edition). 5. 17. 2011. http://dx.doi.org/10.1016/j.rppnen.2011.09.002 . 10.1016/j.rppnen.2011.09.002 . Revista Portuguesa de Pneumologia (English Edition)

Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR

Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2011. Journal of Medicinal Chemistry. 6375 - 6393. 18. 54. 2011. http://dx.doi.org/10.1021/jm200803d . 10.1021/jm200803d . Journal of Medicinal Chemistry

Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging

Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo, 2011. Chemical Communications. 38. 47. 2011. http://dx.doi.org/10.1039/c1cc14019a . 10.1039/c1cc14019a . published Chemical Communications

Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes

Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2011. Bioorganic and Medicinal Chemistry. 1131 - 1135. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS . 10.1016/j.bmc.2010.07.057 . Bioorganic and Medicinal Chemistry

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2011. Breast Cancer Research and Treatment. 61 - 73. 1. 133. 2011. http://dx.doi.org/10.1007/s10549-011-1688-7 . 10.1007/s10549-011-1688-7 . published Breast Cancer Research and Treatment

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability

Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N., 2010. Brazilian Journal of Medical and Biological Research. 1001 - 1009. 10. 43. 2010. http://dx.doi.org/10.1590/s0100-879x2010007500099 . 10.1590/s0100-879x2010007500099 . published Brazilian Journal of Medical and Biological Research

Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis

Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2010. Journal of Medicinal Chemistry. 7632 - 7638. 21. 53. 2010. http://dx.doi.org/10.1021/jm1007769 . 10.1021/jm1007769 . published Journal of Medicinal Chemistry

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio, 2010. Biotechnology and Bioengineering. 884 - 893. 5. 107. 2010. http://dx.doi.org/10.1002/bit.22858 . 10.1002/bit.22858 . published Biotechnology and Bioengineering

Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment

Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio, 2010. Bioconjugate Chemistry. 157 - 168. 1. 21. 2010. http://dx.doi.org/10.1021/bc9004365 . 10.1021/bc9004365 . published Bioconjugate Chemistry

Liposomal imatinib-mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer

Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2010. The Prostate. 81 - 90. 1. 71. 2010. http://dx.doi.org/10.1002/pros.21224 . 10.1002/pros.21224 . The Prostate

Design of peptide-targeted liposomes containing nucleic acids

Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2010. Biochimica et Biophysica Acta (BBA) - Biomembranes. 433 - 441. 3. 1798. 2010. http://dx.doi.org/10.1016/j.bbamem.2009.12.001 . 10.1016/j.bbamem.2009.12.001 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P., 2010. Bioorganic and Medicinal Chemistry. 4385 - 4396. 12. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS . 10.1016/j.bmc.2010.04.085 . Bioorganic and Medicinal Chemistry

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2010. Cancer Chemotherapy and Pharmacology. 275 - 284. 2. 67. 2010. http://dx.doi.org/10.1007/s00280-010-1315-z . 10.1007/s00280-010-1315-z . published Cancer Chemotherapy and Pharmacology

Targeted Lipoplexes for siRNA Delivery

Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso, 2009. Methods in Enzymology. 267 - 287. 2009. http://dx.doi.org/10.1016/s0076-6879(09)65014-x . 10.1016/s0076-6879(09)65014-x . Methods in Enzymology

Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols

Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2009. Journal of Medicinal Chemistry. 4007 - 4019. 13. 52. 2009. http://dx.doi.org/10.1021/jm9003973 . 10.1021/jm9003973 . published Journal of Medicinal Chemistry

Non-viral lipid-based nanoparticles for cancer systemic gene silencing

João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al, 2008. Journal of Nanoscience and Nanotechnology. 2187 - 2204 . 5. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS . 10.1166/jnn.2008.319 . published Journal of Nanoscience and Nanotechnology

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner

Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2008. Cancer Chemotherapy and Pharmacology. 445 - 454. 3. 64. 2008. http://dx.doi.org/10.1007/s00280-008-0892-6 . 10.1007/s00280-008-0892-6 . published Cancer Chemotherapy and Pharmacology

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer

Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N., 2008. Cytometry Part A. 1165 - 1172. 12. 73A. 2008. http://dx.doi.org/10.1002/cyto.a.20634 . 10.1002/cyto.a.20634 . published Cytometry Part A

Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality

Moreira, João Nuno; Santos, Adriana; Simões, Sérgio, 2006. Reviews on Recent Clinical Trials. 217 - 235. 3. 1. 2006. http://dx.doi.org/10.2174/157488706778250050 . 10.2174/157488706778250050 . published Reviews on Recent Clinical Trials

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S, 2005. European Journal of Pharmaceutics and Biopharmaceutics. 359 - 366. 2. 59. 2005. http://dx.doi.org/10.1016/j.ejpb.2004.08.012 . 10.1016/j.ejpb.2004.08.012 . published European Journal of Pharmaceutics and Biopharmaceutics

On the formulation of pH-sensitive liposomes with long circulation times

Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima, 2004. Advanced Drug Delivery Reviews. 947 - 965. 7. 56. 2004. http://dx.doi.org/10.1016/j.addr.2003.10.038 . 10.1016/j.addr.2003.10.038 . Advanced Drug Delivery Reviews

Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer

Moreira, J.N.; Gaspar, R., 2004. Brazilian Journal of Medical and Biological Research. 1185 - 1192. 8. 37. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS . 10.1590/s0100-879x2004000800008 . published Brazilian Journal of Medical and Biological Research

Technology evaluation: LErafAON, NeoPharm

Moreira, J.N.; Simões, S., 2003. Current Opinion in Molecular Therapeutics. 547 - 552. 5. 5. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS . published Current Opinion in Molecular Therapeutics

Adventures in targeting

Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D., 2002. Journal of Liposome Research. 5 - 12. 1-2. 12. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS . 10.1081/LPR-120004771 . Journal of Liposome Research

Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity

Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M., 2002. Pharmaceutical Research. 265 - 269. 3. 19. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS . 10.1023/A:1014434732752 . published Pharmaceutical Research

Targeting Stealth liposomes in a murine model of human small cell lung cancer

Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M., 2001. Biochimica et Biophysica Acta (BBA) - Biomembranes. 167 - 176. 2. 1515. 2001. http://dx.doi.org/10.1016/s0005-2736(01)00411-4 . 10.1016/s0005-2736(01)00411-4 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer

Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M., 2001. Biochimica et Biophysica Acta - Biomembranes. 303 - 317. 2. 1514. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS . 10.1016/S0005-2736(01)00386-8 . published Biochimica et Biophysica Acta - Biomembranes

Carboplatin liposomes coated with O-palmitoylpullulan: In vitro characterization

Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L., 1997. International Journal of Pharmaceutics. 153 - 164. 2. 147. 1997. http://dx.doi.org/10.1016/s0378-5173(96)04808-9 . 10.1016/s0378-5173(96)04808-9 . published International Journal of Pharmaceutics

Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)

Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L., 1996. Journal of Materials Science: Materials in Medicine. 301 - 303. 5. 7. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS . 10.1007/bf00058571 . published Journal of Materials Science: Materials in Medicine

Characterization of the in vitro dissolution of some commercial sustained release theophylline dosage forms

Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A., 1994. Drug Development and Industrial Pharmacy. 1471 - 1483. 8. 20. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS . Drug Development and Industrial Pharmacy