Metabolismo, Envelhecimento e Doença

Resposta do Retículo Endoplasmático (RE) ao stresse e eixo RE-mitocôndria

Stresse do retículo endoplasmático

Disfunção mitocondrial

Membranas associadas à mitocôndria (MAMs)

Doenças psiquiátricas


Linhas de interesse

Alterações no metabolismo lipídico e energético associadas à doença de Alzheimer: papel das Membranas Associadas à Mitocôndria (MAMs)

Alterações morfológicas e funcionais nas Membranas Associadas à Mitocôndria (MAM) na doença bipolar e esquizofrenia

Bioatividade de extratos e compostos isolados obtidos de recursos naturais, para desenvolvimento de estratégias sustentáveis de prevenção/tratamento/cuidado

Visão Geral

A nossa missão é a de investigar as bases moleculares de doenças neuropsiquiátricas, nomeadamente doenças neurodegenerativas associadas ao envelhecimento como a doença de Alzheimer, e doenças mentais severas como a doença bipolar e a esquizofrenia, com o intuito de identificar potenciais aplicações no diagnóstico, prognóstico e terapia. Para isso usamos vários modelos de doença como frações sub-celulares, linhas celulares e culturas primárias, células obtidas de controlos saudáveis versus doentes e ainda murganhos transgénicos, juntamente com múltiplas abordagens experimentais incluindo bioquímica, biologia celular e molecular e análise de comportamento animal. A investigação do nosso grupo foca a desregulação associada à doença da resposta ao stresse do retículo endoplasmático (RE) e da mitocôndria, e estamos também interessados em compreender de que modo distúrbios nos contactos próximos RE-mitocôndria (MAMs), afetam patologicamente as respostas ao stresse. Os nossos estudos podem contribuir para o desenvolvimento de novas terapias para as doenças mencionadas atrás promovendo a saúde e bem-estar, particularmente de estratégias pleotrópicas modificadoras de doença baseadas em recursos naturais.

Artigos em Destaque

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Informação sobre artigos em revista, actualizada a 16-02-2025, a partir da plataforma CIÊNCIAVITAE.

Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al, 2021. Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/5/522 . 10.3390/biomedicines9050522 . Biomedicines

Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of <i>Eucalyptus globulus</i> Leaves

Patrícia Moreira; Fábio J. Sousa; Patrícia Matos; Brites, G; Maria José Gonçalves; Carlos Cavaleiro; Artur Figueirinha; et al, 2022. Pharmaceutics. 2022. https://www.mdpi.com/1999-4923/14/3/561 . 10.3390/pharmaceutics14030561 . Pharmaceutics

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimers Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . published Biomedicines

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

Sofia mori, 2022. Cellular and Molecular Life Sciences. 2022. accepted Cellular and Molecular Life Sciences

A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A., 2015. Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014 . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging


Publicações

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Informação sobre artigos em revista, actualizada a 16-02-2025, a partir da plataforma CIÊNCIAVITAE.

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Moreira, Patrícia; Macedo, Jéssica; Matos, Patrícia; Bicker, Joana; Fortuna, Ana; Figueirinha, Artur; Salgueiro, Lígia; et al, 2024. Biomedicine &amp; Pharmacotherapy. 181. 2024. https://doi.org/10.1016/j.biopha.2024.117652 . 10.1016/j.biopha.2024.117652 . Biomedicine &amp; Pharmacotherapy

The link between alterations in circadian rhythms and lipid metabolism in bipolar disorder: the lipid droplets hypothesis

Pereira, Ana Catarina; Serrano-Cuñarro, Laura; Cruz, Maria Teresa; Cavadas, Cláudia; Pereira, Cláudia Maria Fragão, 2024. Brazilian Journal of Psychiatry. 2024. https://doi.org/10.47626/1516-4446-2024-3670 . 10.47626/1516-4446-2024-3670 . Brazilian Journal of Psychiatry

Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease

Tânia Fernandes; Tânia Melo; Tiago Conde; Bruna Neves; Pedro Domingues; Rosa Resende; Cláudia F. Pereira; Paula I. Moreira; Maria Rosário Domingues, 2024. Journal of Neurochemistry. 2024. https://doi.org/10.1111/jnc.16072 . 10.1111/jnc.16072 . Journal of Neurochemistry

Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging

Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro, 2023. Plants. 2023. https://doi.org/10.3390/plants12213741 . 10.3390/plants12213741 . Plants

Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation

Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24076226 . 10.3390/ijms24076226 . International Journal of Molecular Sciences

An integrated green process for the extraction of triterpenic acids from Eucalyptus globulus leaves after hydrodistillation

Cátia S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Alexandre Gaspar; Carlos Pascoal Neto; Paula C. R. O. Pinto; et al, 2023. RSC Sustainability. 2023. https://doi.org/10.1039/D3SU00076A . 10.1039/D3SU00076A . RSC Sustainability

A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases

Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2023. Biology. 2023. https://doi.org/10.3390/biology12030414 . 10.3390/biology12030414 . Biology

Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes

Pereira, Ana Catarina; Madeira, Nuno; Morais, Sofia; Macedo, António; Cruz, Maria Teresa; Pereira, Cláudia M. F., 2022. Cells. 3. 11. 2022. http://dx.doi.org/10.3390/cells11030433 . 10.3390/cells11030433 . accepted Cells

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

Sofia mori, 2022. Cellular and Molecular Life Sciences. 2022. accepted Cellular and Molecular Life Sciences

Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes

Conte, Fernanda Lopes; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, Patrícia; et al, 2022. Phytomedicine Plus. 2. 2. 2022. http://dx.doi.org/10.1016/j.phyplu.2022.100231 . 10.1016/j.phyplu.2022.100231 . Phytomedicine Plus

Bioactive Bacterial Nanocellulose Membranes Enriched with Eucalyptus globulus Labill. Leaves Aqueous Extract for Anti-Aging Skin Care Applications

Almeida, Tânia; Moreira, Patrícia; Sousa, Fábio J.; Pereira, Cláudia; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R., 2022. Materials. 5. 15. 2022. http://dx.doi.org/10.3390/ma15051982 . 10.3390/ma15051982 . published Materials

Synergistic hypoglycemic and hypolipidemic effects of ¿-3 and ¿-6 fatty acids from Indian flax and sesame seed oils in streptozotocin-induced diabetic rats

Sunil Chikkalakshmipura Gurumallu; Tareq N. AlRamadneh; Halugudde Nagaraja Sarjan; Ashwini Bhaskar; Cláudia Maria Fragão Pereira; Rajesha Javaraiah, 2022. Phytomedicine Plus. 2022. https://doi.org/10.1016/j.phyplu.2022.100284 . 10.1016/j.phyplu.2022.100284 . Phytomedicine Plus

Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy

Patrícia Moreira; Patrícia Matos; Artur Figueirinha; Lígia Salgueiro; Maria Teresa Batista; Pedro Costa Branco; Maria Teresa Cruz; Cláudia Fragão Pereira, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms23158812 . 10.3390/ijms23158812 . International Journal of Molecular Sciences

ER-Mitochondria contacts modulate ROS-mediated signaling and oxidative stress in brain disorders: the key role of Sigma-1 receptor.

Resende, Rosa; Fernandes, Tânia; Pereira, Ana Catarina; Marques, Ana Patrícia; Pereira, Cláudia Fragão, 2022. Antioxidants & Redox Signaling. 2022. http://dx.doi.org/10.1089/ars.2020.8231 . 10.1089/ars.2020.8231 . published Antioxidants & Redox Signaling

Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of <i>Eucalyptus globulus</i> Leaves

Patrícia Moreira; Fábio J. Sousa; Patrícia Matos; Brites, G; Maria José Gonçalves; Carlos Cavaleiro; Artur Figueirinha; et al, 2022. Pharmaceutics. 2022. https://www.mdpi.com/1999-4923/14/3/561 . 10.3390/pharmaceutics14030561 . Pharmaceutics

Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets

Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T., 2021. Pharmacological Research. 163. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105325 . 10.1016/j.phrs.2020.105325 . published Pharmacological Research

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Pereira, Cláudia, 2021. Autophagy. 1 - 382. 8. 2021. published Autophagy

Therapies for Alzheimer’s disease: a metabolic perspective

Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana, 2021. Molecular Genetics and Metabolism. 21. S1096-71. 2021. http://dx.doi.org/10.1016/j.ymgme.2021.01.011 . 10.1016/j.ymgme.2021.01.011 . published Molecular Genetics and Metabolism

Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water

Rocha, Maria Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Pereira, Cláudia; Moreira, Patrícia; Salgueiro, Lígia; Figueirinha, Artur, 2021. Journal of Ethnopharmacology. 276. 2021. http://dx.doi.org/10.1016/j.jep.2021.114146 . 10.1016/j.jep.2021.114146 . published Journal of Ethnopharmacology

Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al, 2021. Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/5/522 . 10.3390/biomedicines9050522 . Biomedicines

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimers Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . published Biomedicines

Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model

Fernandes, Tânia; Resende, Rosa; Domingues, Maria R.; Paula I. Moreira; Pereira, Cláudia Fragão, 2021. European Journal of Clinical Investigation. S1. 51. 2021. http://dx.doi.org/10.1111/eci.13567 . published European Journal of Clinical Investigation

Anti-inflammatory potential of Portuguese thermal waters

Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al, 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-79394-9 . 10.1038/s41598-020-79394-9 . published Scientific Reports

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al, 2020. International Journal of Molecular Sciences. 20. 21. 2020. http://dx.doi.org/10.3390/ijms21207791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata

Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, 2020. International Journal of Molecular Sciences. 1814 - 1830. 5. 21. 2020. https://doi.org/10.3390/ijms21051814 . 10.3390/ijms21051814 . International Journal of Molecular Sciences

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 165752 - 165752. 6. 1866. 2020. https://doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; Martinez-de-Oliveira, José; et al, 2020. International Journal of Biometeorology. 1957 - 1968. 11. 64. 2020. http://dx.doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . published International Journal of Biometeorology

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira, 2020. International Journal of Molecular Sciences. 1125 - 1125. 3. 21. 2020. https://doi.org/10.3390/ijms21031125 . 10.3390/ijms21031125 . International Journal of Molecular Sciences

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimers Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, 2020. Journal of Alzheimer's Disease. 1317 - 1337. 6. 70. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . published Journal of Alzheimer's Disease

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”

Jan Parys; C Pereira; Carlos Villalobos, 2019. International Journal of Molecular Sciences. 2019. https://www.mdpi.com/1422-0067/20/24/6263 . 10.3390/ijms20246263 . International Journal of Molecular Sciences

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, 2019. Environmental Geochemistry and Health. 2019. http://dx.doi.org/10.1007/s10653-019-00473-6 . 10.1007/s10653-019-00473-6 . published Environmental Geochemistry and Health

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R., 2018. Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00178 . 10.3389/fchem.2018.00178 . published Frontiers in Chemistry

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I., 2017. Molecular Neurobiology. 154 - 168. 1. 54. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease

Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S., 2017. European Journal of Clinical Investigation. 24 - 25. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035 . European Journal of Clinical Investigation

Bioactivity and safety profile of Daucus carota subsp maximus essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., 2015. Industrial Crops and Products. 218 - 224. 77. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366065200028&KeyUID=WOS:000366065200028 . 10.1016/j.indcrop.2015.08.037 . Industrial Crops and Products

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, Ana Catarina R. G.; Moreira, Paula I.; Oliveira, Catarina R.; Cardoso, Sandra M.; Pinton, Paolo; Pereira, Claudia F., 2015. Molecular Neurobiology. 610 - 622. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800015&KeyUID=WOS:000351311800015 . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

Correia, Sonia C.; Resende, Rosa; Moreira, Paula I.; Pereira, Claudia M., 2015. DNA and Cell Biology. 261 - 273. 4. 34. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352342300005&KeyUID=WOS:000352342300005 . 10.1089/dna.2014.2757 . DNA and Cell Biology

A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A., 2015. Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014 . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

Mota, Sandra I.; Costa, Rui O.; Ferreira, Ildete L.; Santana, Isabel; Caldeira, Gladys L.; Padovano, Carmela; Fonseca, Ana C.; et al, 2015. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1428 - 1441. 7. 1852. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355715200021&KeyUID=WOS:000355715200021 . 10.1016/j.bbadis.2015.03.015 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Daucus carota subsp gummifer essential oil as a natural source of antifungal and anti-inflammatory drugs

Valente, J.; Zuzarte, M.; Resende, R.; Goncalves, M. J.; Cavaleiro, C.; Pereira, C. F.; Cruz, M. T.; Salgueiro, L., 2015. Industrial Crops and Products. 361 - 366. 65. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349430000046&KeyUID=WOS:000349430000046 . 10.1016/j.indcrop.2014.11.014 . Industrial Crops and Products

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

Placido, Ana I.; Oliveira, Catarina R.; Moreira, Paula I.; Pereira, Claudia Maria F., 2015. Molecular Neurobiology. 571 - 590. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800012&KeyUID=WOS:000351311800012 . 10.1007/s12035-014-8819-1 . Molecular Neurobiology

New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease

Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E.; Ferreira-Marques, Marisa, 2015. Sinapse. 2015. http://www.geecd.org/images/GEECDFiles/29a_Reuniao_do_GEECD_ResumosSinapse.pdf . published Sinapse

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

Placido, Ana I.; Pereira, Claudia M. F.; Duarte, Ana I.; Candeias, Emanuel; Correia, Sonia C.; Carvalho, Cristina; Cardoso, Susana; Oliveira, Catarina R.; Moreira, Paula I., 2015. Cns & Neurological Disorders-Drug Targets. 518 - 533. 4. 14. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354179100012&KeyUID=WOS:000354179100012 . 10.2174/1871527314666150429112353 . Cns & Neurological Disorders-Drug Targets

BRI2 ectodomain affects A beta(42) fibrillation and tau truncation in human neuroblastoma cells

Del Campo, M.; Oliveira, C. R.; Scheper, W.; Zwart, R.; Korth, C.; Mueller-Schiffmann, A.; Kostallas, G.; et al, 2015. Cellular and Molecular Life Sciences. 1599 - 1611. 8. 72. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351456000012&KeyUID=WOS:000351456000012 . 10.1007/s00018-014-1769-y . Cellular and Molecular Life Sciences

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid- beta Oligomers in a Hypothalamic cell Line

Gomes, S.; Martins, I.; Fonseca, A. C. R. G.; Oliveira, C. R.; Resende, R.; Pereira, C. M. F., 2014. Journal of Neuroendocrinology. 176 - 185. 3. 26. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333329700004&KeyUID=WOS:000333329700004 . 10.1111/jne.12138 . Journal of Neuroendocrinology

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, Ana Catarina; Oliveira, Catarina R.; Pereira, Claudia F.; Cardoso, Sandra M., 2014. Biochimica Et Biophysica Acta-Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335627900010&KeyUID=WOS:000335627900010 . 10.1016/j.bbamcr.2014.02.016 . Biochimica Et Biophysica Acta-Molecular Cell Research

MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE

Campo Milan, Marta Del; Pereira, Cláudia; Scheper, W.; Zwart, R.; Hoozemans, Jeroen; Oliveira, Catarina; Teunissen, Charlotte, 2014. Alzheimer's & Dementia. 4. 10. 2014. http://dx.doi.org/10.1016/j.jalz.2014.05.323 . 10.1016/j.jalz.2014.05.323 . published Alzheimer's & Dementia

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Placido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; et al, 2014. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340975400016&KeyUID=WOS:000340975400016 . 10.1016/j.bbadis.2014.05.003 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Antifungal and anti-inflammatory claims for wild carrot essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., 2014. Planta Medica. 1454 - 1454. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400318&KeyUID=WOS:000345550400318 . Planta Medica

Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers

Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., 2013. Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Claudia F., 2013. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327567600030&KeyUID=WOS:000327567600030 . 10.1016/j.bbadis.2013.08.007 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F., 2013. Neurochemical Research. 797 - 806. 4. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS . 10.1007/s11064-013-0982-7 . Neurochemical Research

Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons

Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2013. Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers

Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., 2012. Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell

Endoplasmic reticulum stress: A new playER in tauopathies

Ferreiro, E.; Pereira, C.M.F., 2012. Journal of Pathology. 687 - 692. 5. 226. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS . 10.1002/path.3977 . Journal of Pathology

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.

Ferreiro E; Baldeiras I; Ferreira IL; Costa RO; Rego AC; Pereira CF; Oliveira CR, 2012. 2012. http://europepmc.org/abstract/med/22701485 . 10.1155/2012/735206 .

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

Mota, Sandra I.; Ferreira, Ildete L.; Pereira, Claudia; Oliveira, Catarina R.; Cristina Rego, A., 2012. Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308863600009&KeyUID=WOS:000308863600009 . Current Alzheimer Research

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures

Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C., 2012. Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS . 10.2174/156720512802455322 . Current Alzheimer Research

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice

Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F., 2012. Neuroscience. 256 - 266. 220. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.06.029 . Neuroscience

Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons

Ferreiro, Elisabete; Ferreira, Ildete Luisa; Cardoso, Joao M.; Pereira, Cláudia; Resende de Oliveira, Catarina; Rego, Ana Cristina Carvalho, 2011. Alzheimer's & Dementia: Journal of Alzheimer's Association. 4. 7. 2011. published Alzheimer's & Dementia: Journal of Alzheimer's Association

Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons

Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho, 2011. Journal of Neurodegenerative Disorders. Supplement. 1. 2011. published Journal of Neurodegenerative Disorders

Epigenetics in neurodegeneration: A new layer of complexity

Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F., 2011. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 348 - 355. 2. 35. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS . 10.1016/j.pnpbp.2010.08.008 . Progress in Neuro-Psychopharmacology and Biological Psychiatry

Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients

Ferreira, Ildete Luisa; Mota, Sandra Isabel; Costa, Rui Miguel Oliveira da; Padovano, C; Fonseca, Ana Catarina Ribeiro da Graça; Letra, Liliana; Resende de Oliveira, Catarina; et al, 2011. Journal of Neurodegenerative Diseases. Supplement. 1. 2011. published Journal of Neurodegenerative Diseases

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

Multiple Defects in Energy Metabolism in Alzheimer's Disease

Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F., 2010. Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285183900002&KeyUID=WOS:000285183900002 . Current Drug Targets

Alzheimer's disease: The quest to understand complexity

Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 373 - 383. 2. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS . 10.3233/JAD-2010-100303 . Journal of Alzheimer's Disease

ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE

Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F., 2010. Advances in Medicine and Biology, Vol 2. 197 - 210. 2. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007 . Advances in Medicine and Biology, Vol 2

Cholesterol and statins in Alzheimer's disease: Current controversies

Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., 2010. Experimental Neurology. 282 - 293. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.09.013 . Experimental Neurology

Epigenetics and Neurodegeneration: A Connection Overlooked

Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F., 2010. Epigenetics: Mechanism, Functions and Human Effects. 241 - 252. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278550400010&KeyUID=WOS:000278550400010 . Epigenetics: Mechanism, Functions and Human Effects

Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide

Ferreiro, E.; Costa, R.; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C. R.; Pereira, C., 2009. Journal of the Neurological Sciences. 280 - 281. 1-2. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400202&KeyUID=WOS:000268609400202 . 10.1016/j.jns.2009.02.158 . Journal of the Neurological Sciences

Neuroprotective effects of statins in an in vitro model of alzheimer's disease

Fonseca, A.C.R.G.; Proena, T.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., 2009. Journal of Alzheimer's Disease. 503 - 517. 3. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849099662&partnerID=MN8TOARS . 10.3233/JAD-2009-1067 . Journal of Alzheimer's Disease

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

Statins prevent beta-amyloid-induced toxicity in cortical neurons

Pereira, Cláudia; Fonseca, Ana Catarina Ribeiro da Graça; Resende, Rosa; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, C. M. F.; Fonseca, A. C.; et al, 2009. Journal of the Neurological Sciences. 281 - 281. 1. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400203&KeyUID=WOS:000268609400203 . 10.1016/j.jns.2009.02.159 . published Journal of the Neurological Sciences

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2008. Neurobiology of Disease. 331 - 342. 3. 30. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS . 10.1016/j.nbd.2008.02.003 . Neurobiology of Disease

ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R., 2008. Journal of Neuroscience Research. 2091 - 2099. 9. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS . 10.1002/jnr.21648 . Journal of Neuroscience Research

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., 2008. Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide

Pereira, Cláudia; Ferreiro, Elisabete; Costa, Rui Miguel Oliveira da; Resende, Rosa; Morais Cardoso, Sandra; Resende de Oliveira, Catarina, 2008. Alzheimer’s and Dementia . T345 - T345. 4. 4. 2008. published Alzheimer’s and Dementia

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C., 2008. Neuroscience. 725 - 737. 3. 155. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.06.036 . Neuroscience

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., 2007. Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, 2007. Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, Elisabete; Eufrasio, Ana; Pereira, Claudia; Oliveira, Catarina R.; Rego, A. Cristina; Ferreiro, E.; Eufrásio, A.; et al, 2007. Journal of Alzheimers Disease. 223 - 228. 3. 12. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252300000003&KeyUID=WOS:000252300000003 . Journal of Alzheimers Disease

Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?

Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia, 2007. Journal of Neurochemistry. 68 - 69. Supplement. 102. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162 . published Journal of Neurochemistry

In vitro study of Amyloid-ß peptide toxicity. The role of physical state.

Resende, Rosa; Batista, M; Pereira, Cláudia; Resende de Oliveira, Catarina, 2006. Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders. 455 - 459. 2006. published Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., 2006. Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Endoplasmic reticulum dysfunction and oxidative stress induced by the prion peptide

Ferreiro, EB; Oliveira, CR; Pereira, CM, 2005. Journal of Neurochemistry. 174 - 175. 94. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231673401076&KeyUID=WOS:000231673401076 . Journal of Neurochemistry

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Mechanism of amyloid-beta induced early synaptotoxicity.

Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia, 2005. Sinapse. 101 - 101. 1. 5 . 2005. published Sinapse

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

The crosstalk between the endoplasmic reticulum and mitochondria in Alzheimer's disease

Cardoso, SM; Ferreiro, E; Oliveira, CR; Pereira, C, 2005. Febs Journal. 55 - 55. 272. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234826100186&KeyUID=WOS:000234826100186 . Febs Journal

Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.

Loureiro, G; Rabaca, M A; Blanco, B; Andrade, S; Chieira, C; Pereira, C, 2005. Allergologia et immunopathologia. 192 - 8. 4. 33. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:16045856&KeyUID=MEDLINE:16045856 . 10.1157/13077742 . Allergologia et immunopathologia

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.; Pereira, C; Ferreiro, E; Cardoso, SM; de Oliveira, CR, 2004. Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . 10.1385/JMN:23:1-2:097 . Journal of Molecular Neuroscience

Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2004. Journal of Neuroscience Research. 872 - 880. 6. 76. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS . 10.1002/jnr.20135 . Journal of Neuroscience Research

[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].

Pereira, Claudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina R, 2003. Acta medica portuguesa. 401 - 6. 6. 16. 2003. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:15631851&KeyUID=MEDLINE:15631851 . Acta medica portuguesa

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., 2003. Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis

Pereira, CF; de Oliveira, CR, 2000. Neuroscience Research. 227 - 236. 3. 37. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008 . 10.1016/S0168-0102(00)00124-3 . Neuroscience Research

Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide

Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina, 2000. Antioxidants & Redox Signaling. 317 - 325. 2. 2. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014 . 10.1089/ars.2000.2.2-317 . Antioxidants & Redox Signaling

Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells

Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R., 2000. Free Radical Research. 497 - 506. 5. 33. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006 . 10.1080/10715760000301041 . Free Radical Research

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants

Pereira, C.; Santos, M.S.; Oliveira, C., 1999. Neurobiology of Disease. 209 - 219. 3. 6. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS . 10.1006/nbdi.1999.0241 . Neurobiology of Disease

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Metabolic inhibition increases glutamate susceptibility on a PC12 cell line

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Journal of Neuroscience Research. 360 - 370. 3. 51. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009 . 10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7 . Journal of Neuroscience Research

Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Neuroreport. 1749 - 1755. 8. 9. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015 . 10.1097/00001756-199806010-00015 . Neuroreport

Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress

Pereira, C.M.F.; Oliveira, C.R., 1997. Free Radical Biology and Medicine. 637 - 647. 4. 23. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS . 10.1016/S0891-5849(97)00020-8 . Free Radical Biology and Medicine

Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress

Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C., 1996. Brain Research. 269 - 277. 1-2. 713. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS . 10.1016/0006-8993(95)01554-X . Brain Research

Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes

Pereira, Cláudia; Resende de Oliveira, Catarina, 1993. Journal of Neurochemistry. S151D - S151D. supplement. 1993. published Journal of Neurochemistry

Projectos I&D Passados

Prémios

2021

"Mulheres na Ciência” tributo às mulheres portuguesas cientistas, Ciência Viva

2004

Prémio “L’Oréal para as mulheres na Ciência”, L’Oréal Portugal/UNESCO/FCT

2018

"Bolsa de Mérito da Universidade de Coimbra”, entregue a Ana Catarina Pereira (Mestrado em Biologia Celular e Molecular)

2022

Melhor Apresentação Oral, 56ª Reunião Científica Anual da Sociedade Europeia de Investigação Clínica (Itália)

Prize attributed to Ana Catarina Pereira (PhD student)

2013

Prémio World Biomedical Frontiers Costa et al. Aging Cell 2012. DOI:10.1111/j.1474-9726.2012.00848.x, selecionado para apresentação em World Biomedical Frontiers (http://biomedfrontiers.org/

2010

Prémio Envelhecimento e Demência Cerebral, Doença de Alzheimer 2010 (Pfizer & Sociedade Portuguesa de Neurociências). Interaction between endoplasmic reticulum stress-mediated endothelial dys

2012

Bolsa de Estudo Edgar Cruz e Silva 2012. Grupo de Estudos de Envelhecimento Cerebral e Demência/Santa Casa da Misericórdia. Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neu

2017

Bolsa de Estudo Edgar Cruz e Silva 2017. Grupo de Estudos de Envelhecimento Cerebral e Demência/Santa Casa da Misericórdia. New BACE1 inhibitors for the treatment of Alzheimer’s disease: an a

2019

Prémio de Melhor Apresentação Oral 1º Encontro Anual em Ciências Farmacêuticas, Faculdade de Medicina, Universidade de Coimbra (Ana Catarina Pereira, aluna de Doutoramento)

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