Deuterium
Lipogenesis
Isotopomers
Glycogen
Krebs Cycle
Quantifying fructose metabolism by mesenteric adipocytes in mouse models
Development of oxygen-18 enriched water as a tracer of carbohydrate biosynthesis
Coupling of pentose phosphate pathway and fatty acid synthesis fluxes in different disease states
Quantifying nutrient metabolism in cultured fish
Intermediary metabolism refers to the intracellular processes by which nutrient carbons are biochemically transformed into storage or structural cell products. Our mission is to develop methodologies for measuring these processes in living systems. Our objectives include the application these measurements to better understand nutrient metabolism in diseases such as Type 2 Diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), whose increased incidences are in part related to changes in food intake. Our techniques are based on the use of non-radioactive stable-isotope metabolic tracers coupled with noninvasive assays of key metabolites that encode the labeling information from the tracers. Our expertise is in the use of high-resolution nuclear magnetic resonance (NMR) techniques coupled with chemical derivatization of specific metabolites to acquire more precise information on the metabolic fate of the isotopic tracers. This in turn allows the development of more detailed and realistic metabolic flux models to describe nutrient metabolism. Currently, we are focused on the metabolism of fructose by the liver and other tissues. Fructose consumption in Western Societieshas sharply increased in recent decades and is implicated in the surge of T2D and NAFLD in these communities. Transformation of fructose into saturated fatty acids may play an important role in the onset and progression of these diseases.
Information about journal articles, updated at 18-04-2024, from platform CIÊNCIAVITAE.
Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition
Vitor Ferreira; Cintia Folgueira; María García-Altares; Maria Guillén; Mónica Ruíz-Rosario; Giada DiNunzio; Irma Garcia-Martinez; et al, 2023. Redox Biology. 102741 - 102741. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102741 . 10.1016/j.redox.2023.102741 . Redox Biology
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241914542 . 10.3390/ijms241914542 . International Journal of Molecular Sciences
Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer
Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010376 . 10.3390/ijms25010376 . International Journal of Molecular Sciences
The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar
João Pessoa; Getachew D. Belew; Cristina Barroso; Conceição Egas; John G. Jones, 2023. Nutrients. 2023. https://doi.org/10.3390/nu15092097 . 10.3390/nu15092097 . Nutrients
A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction
Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G., 2022. NMR in Biomedicine. 2022. https://publons.com/wos-op/publon/50808444/ . 10.1002/NBM.4648 . NMR in Biomedicine
Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage
Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al, 2022. Free Radical Biology and Medicine. 2022. https://publons.com/wos-op/publon/51770689/ . 10.1016/J.FREERADBIOMED.2021.12.304 . Free Radical Biology and Medicine
The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women
Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A., 2022. European Journal of Clinical Investigation. 2022. https://publons.com/wos-op/publon/49682785/ . 10.1111/ECI.13731 . European Journal of Clinical Investigation
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al, 2022. Redox Biology. 2022. https://publons.com/wos-op/publon/53932683/ . 10.1016/J.REDOX.2022.102400 . Redox Biology
De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers
Getachew Debas Belew; John G. Jones, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13733 . 10.1111/eci.13733 . European Journal of Clinical Investigation
Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice
Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al, 2022. NMR in Biomedicine. 2022. https://publons.com/wos-op/publon/54600422/ . 10.1002/NBM.4837 . NMR in Biomedicine
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes
Margarida Coelho; Patarrao RS; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al, 2022. Nutrients. 2022. https://www.mdpi.com/2072-6643/15/1/4 . 10.3390/nu15010004 . Nutrients
Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism
Ivan Viegas; Giada Di Nunzio; Getachew D. Belew; Alejandra N. Torres; João G. Silva; Luis Perpétuo; Cristina Barosa; Ludgero C. Tavares; John G. Jones, 2022. Metabolites. 2022. https://doi.org/10.3390/metabo12111142 . 10.3390/metabo12111142 . Metabolites
Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
John G. Jones, 2021. Metabolites. 751 - 751. 11. 11. 2021. https://doi.org/10.3390/metabo11110751 . 10.3390/metabo11110751 . Metabolites
Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects
Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones, 2021. Journal of Clinical Medicine. 2021. https://doi.org/10.3390/jcm10040596 . 10.3390/jcm10040596 . Journal of Clinical Medicine
Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance
Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G., 2021. NMR in Biomedicine. 2021. https://publons.com/wos-op/publon/50291978/ . 10.1002/NBM.4632 . NMR in Biomedicine
Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells
Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A., 2021. Molecular Neurobiology. 2021. https://publons.com/wos-op/publon/50262822/ . 10.1007/S12035-021-02630-4 . Molecular Neurobiology
Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans
Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al, 2021. The Journal of Clinical Endocrinology & Metabolism. 2021. https://publons.com/wos-op/publon/46827652/ . 10.1210/CLINEM/DGAB100 . The Journal of Clinical Endocrinology & Metabolism
Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases
Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo, 2021. The Journal of Pathology. 2021. https://publons.com/wos-op/publon/49707570/ . 10.1002/PATH.5777 . The Journal of Pathology
Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits
Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al, 2021. Metabolism. 2021. https://publons.com/wos-op/publon/41702324/ . 10.1016/J.METABOL.2021.154735 . Metabolism
Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases
Sousa-Lima, Ines; Kim, Hyun Jeong; Jones, John; Kim, Young-Bum, 2021. Diabetes & Metabolism Journal. 2021. https://publons.com/wos-op/publon/55608243/ . 10.4093/DMJ.2021.0197 . Diabetes & Metabolism Journal
The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. https://doi.org/10.3390/ijms21155272 . 10.3390/ijms21155272 . International Journal of Molecular Sciences
p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose
Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G., 2020. Analytical Biochemistry. 590. 2020. http://dx.doi.org/10.1016/j.ab.2019.113511 . 10.1016/j.ab.2019.113511 . Analytical Biochemistry
Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice
Jones, John, 2020. Scientific Reports. 2020. http://dx.doi.org/10.1038/s41598-020-69820-3 . 10.1038/s41598-020-69820-3 . Scientific Reports
Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance
Jones, John, 2020. JCI Insight. 2020. http://dx.doi.org/10.1172/jci.insight.134520 . 10.1172/jci.insight.134520 . JCI Insight
Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics
Jones, John, 2020. Frontiers in Physiology. 2020. http://dx.doi.org/10.3389/fphys.2020.00205 . 10.3389/fphys.2020.00205 . Frontiers in Physiology
Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose
Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones, 2020. Magnetic Resonance in Medicine. 2765 - 2771. 5. 84. 2020. https://doi.org/10.1002/mrm.28286 . 10.1002/mrm.28286 . Magnetic Resonance in Medicine
Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals
Jones, John, 2020. NMR in Biomedicine. 2020. http://dx.doi.org/10.1002/nbm.4395 . 10.1002/nbm.4395 . NMR in Biomedicine
Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)
Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M., 2019. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 170 - 176. 231. 2019. http://dx.doi.org/10.1016/j.cbpa.2019.02.025 . 10.1016/j.cbpa.2019.02.025 . Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Understanding how birds rebuild fat stores during migration: insights from an experimental study
Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A., 2019. Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-46487-z . 10.1038/s41598-019-46487-z . Scientific Reports
Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue
Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G., 2019. Metabolic Engineering. 69 - 76. 56. 2019. http://dx.doi.org/10.1016/j.ymben.2019.08.018 . 10.1016/j.ymben.2019.08.018 . Metabolic Engineering
The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata
Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al, 2019. Biomolecules. 297 - 297. 8. 9. 2019. https://doi.org/10.3390/biom9080297 . 10.3390/biom9080297 . Biomolecules
Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis
Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones, 2019. Journal of Lipid Research. 2050 - 2056. 12. 60. 2019. https://doi.org/10.1194/jlr.RA119000354 . 10.1194/jlr.RA119000354 . Journal of Lipid Research
Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish
Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G., 2019. Aquaculture. 488 - 495. 498. 2019. http://dx.doi.org/10.1016/j.aquaculture.2018.08.066 . 10.1016/j.aquaculture.2018.08.066 . Aquaculture
27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019
Jones, John, 2019. Cardiovascular Endocrinology & Metabolism. 2019. http://dx.doi.org/10.1097/xce.0000000000000179 . 10.1097/xce.0000000000000179 . Cardiovascular Endocrinology & Metabolism
A Mitochondrial Approach to Cardiovascular Risk and Disease
Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, 2019. Current Pharmaceutical Design. 3175 - 3194. 29. 25. 2019. https://doi.org/10.2174/1389203720666190830163735 . 10.2174/1389203720666190830163735 . Current Pharmaceutical Design
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate
Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al, 2018. Magnetic Resonance in Medicine. 639 - 644. 1. 81. 2018. http://dx.doi.org/10.1002/mrm.27378 . 10.1002/mrm.27378 . Magnetic Resonance in Medicine
Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets
Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al, 2018. Journal of Proteome Research. 2880 - 2891. 8. 17. 2018. http://dx.doi.org/10.1021/acs.jproteome.8b00354 . 10.1021/acs.jproteome.8b00354 . Journal of Proteome Research
Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream
Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G., 2018. Scientific Reports. 8. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419941000005&KeyUID=WOS:000419941000005 . 10.1038/s41598-017-19087-y . Scientific Reports
Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al, 2018. Journal of Clinical Investigation. 5335 - 5350. 12. 128. 2018. https://publons.com/wos-op/publon/19310035/ . 10.1172/JCI63562 . Journal of Clinical Investigation
Improving Metabolic Control Through Functional Foods.
Jones, John G; Silva, Joao C P, 2017. Current medicinal chemistry. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28545368&KeyUID=MEDLINE:28545368 . 10.2174/0929867324666170523130123 . Current medicinal chemistry
Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2
Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A., 2017. Journal of Experimental Biology. 1072 - 1078. 6. 220. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397614200019&KeyUID=WOS:000397614200019 . 10.1242/jeb.150490 . Journal of Experimental Biology
Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype
Flachs, P.; Adamcova, K.; Zouhar, P.; Marques, C.; Janovska, P.; Viegas, I.; Jones, Jg; et al, 2017. International Journal of Obesity. 372 - 380. 3. 41. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395816000003&KeyUID=WOS:000395816000003 . 10.1038/ijo.2016.228 . International Journal of Obesity
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
Hernandez, Elisa Alvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; et al, 2017. Journal of Clinical Investigation. 695 - 708. 2. 127. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000394164100029&KeyUID=WOS:000394164100029 . 10.1172/JCI89444 . Journal of Clinical Investigation
Evidence of extensive plasma glucose recycling following a glucose load in seabass
Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Jones, John G., 2017. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 41 - 48. 211. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406565900006&KeyUID=WOS:000406565900006 . 10.1016/j.cbpa.2017.05.009 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology
Chitosan-Mediated shRNA Knockdown of Cytosolic Alanine Aminotransferase Improves Hepatic Carbohydrate Metabolism
Gonzalez, Juan D.; Silva-Marrero, Jonas I.; Meton, Isidoro; Caballero-Solares, Albert; Viegas, Ivan; Fernandez, Felipe; Minarro, Montserrat; et al, 2016. Marine Biotechnology. 85 - 97. 1. 18. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000378136600007&KeyUID=WOS:000378136600007 . 10.1007/s10126-015-9670-8 . Marine Biotechnology
Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS
Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno, 2016. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376545800032&KeyUID=WOS:000376545800032 . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance
Varghese, Ron T.; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; Rizza, Robert A.; Jones, John G.; Venal, Adrian, 2016. Diabetes. 887 - 892. 4. 65. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372859200008&KeyUID=CCC:000372859200008 . 10.2337/DB15-1593 . Diabetes
Hepatic glucose and lipid metabolism
Jones, John G.; Jones, John G, 2016. Diabetologia. 1098 - 1103. 6. 59. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000378048500004&KeyUID=CCC:000378048500004 . 10.1007/s00125-016-3940-5 . Diabetologia
Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone
Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G.; Jones, John G, 2016. Magnetic Resonance in Medicine. 1781 - 1786. 4. 75. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372910900040&KeyUID=CCC:000372910900040 . 10.1002/mrm.25749 . Magnetic Resonance in Medicine
Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia
Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G., 2016. British Journal of Pharmacology. 267 - 278. 2. 173. 2016. https://publons.com/wos-op/publon/2029575/ . 10.1111/BPH.13362 . British Journal of Pharmacology
Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).
Viegas, Ivan; Jarak, Ivana; Rito, Joao; Carvalho, Rui A; Meton, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G, 2016. Journal of lipid research. 1264 - 72. 7. 57. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27247346&KeyUID=MEDLINE:27247346 . 10.1194/jlr.M067850 . Journal of lipid research
Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans
Varghese, Ron T.; Man, Chiara Dalla; Sharma, Anu; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; et al, 2016. Journal of Clinical Endocrinology & Metabolism. 4816 - 4824. 12. 101. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000390951000035&KeyUID=WOS:000390951000035 . 10.1210/jc.2016-1998 . Journal of Clinical Endocrinology & Metabolism
Determination of muscle protein synthesis rates in fish using (H2O)-H-2 and H-2 NMR analysis of alanine
Marques, Catia; Viegas, Filipa; Rito, Joao; Jones, John; Viegas, Ivan, 2016. Analytical Biochemistry. 111 - 114. 509. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380866800018&KeyUID=WOS:000380866800018 . 10.1016/j.ab.2016.07.011 . Analytical Biochemistry
Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.)
Viegas, Ivan; Rito, Joao; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Meton, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G., 2015. British Journal of Nutrition. 1345 - 1354. 9. 113. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355283800002&KeyUID=WOS:000355283800002 . 10.1017/S0007114515000574 . British Journal of Nutrition
Reduced alpha-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis
Schneeberger, Marc; Gomez-Valades, Alicia G.; Altirriba, Jordi; Sebastian, David; Ramirez, Sara; Garcia, Ainhoa; Esteban, Yaiza; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358324900002&KeyUID=WOS:000358324900002 . 10.1016/j.celrep.2015.06.041 . Cell Reports
Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices
Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G., 2015. Nmr in Biomedicine. 1111 - 1116. 9. 28. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006 . 10.1002/nbm.3355 . Nmr in Biomedicine
Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics
Coelho, Margarida; Nunes, Patricia; Mendes, Vera M.; Manadas, Bruno; Heerschap, Arend; Jones, John G., 2015. Journal of Diabetes Research. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358227400001&KeyUID=WOS:000358227400001 . 10.1155/2015/542029 . Journal of Diabetes Research
Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-C-13] acetate
Burgess, Shawn C.; Merritt, Mathew E.; Jones, John G.; Browning, Jeffrey D.; Sherry, A. Dean; Malloy, Craig R., 2015. Nature Medicine. 20 - 21. 2. 21. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000348974800007&KeyUID=CCC:000348974800007 . 10.1038/NM.3789 . Nature Medicine
Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water
Jones, J.; Kahl, S.; Carvalho, F.; Barosa, C.; Roden, M., 2015. Analytical Biochemistry. 37 - 39. 479. 2015. http://dx.doi.org/10.1016/j.ab.2015.03.018 . 10.1016/j.ab.2015.03.018 . Analytical Biochemistry
Noninvasive stable-isotope tracer methods for the study of hepatic intermediary metabolism
Jones, J. G., 2015. European Journal of Clinical Investigation. 26 - 26. 45. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354124800073&KeyUID=WOS:000354124800073 . European Journal of Clinical Investigation
Identifying Sources of Hepatic Lipogenic Acetyl-CoA Using Stable Isotope Tracers and NMR
John G. Jones, 2014. Advances in Radiology. 2014. https://publons.com/wos-op/publon/49841854/ . 10.1155/2014/109252 . Advances in Radiology
A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice
Duarte, Joao A. G.; Carvalho, Filipa; Pearson, Mackenzie; Horton, Jay D.; Browning, Jeffrey D.; Jones, John G.; Burgess, Shawn C., 2014. Journal of Lipid Research. 2541 - 2553. 12. 55. 2014. 10.1194/jlr.M052308 . Journal of Lipid Research
Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice
Nunes, Patricia M.; Wright, Alan J.; Veltien, Andor; van Asten, Jack J. A.; Tack, Cees J.; Jones, John G.; Heerschap, Arend, 2014. Faseb Journal. 1988 - 1997. 5. 28. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000335336000004&KeyUID=CCC:000335336000004 . 10.1096/FJ.13-241208 . Faseb Journal
Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding
Viegas, Ivan; Caballero-Solares, Albert; Rito, Joao; Giralt, Marina; Pardal, Miguel A.; Meton, Isidoro; Jones, John G.; Baanante, Isabel V., 2014. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 38 - 44. 174. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337851700006&KeyUID=WOS:000337851700006 . 10.1016/j.cbpa.2014.04.004 . Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology
Resolving Futile Glucose Cycling and Glycogenolytic Contributions to Plasma Glucose Levels Following a Glucose Load
Nunes, Patricia M.; Jarak, Ivana; Heerschap, Arend; Jones, John G., 2014. Magnetic Resonance in Medicine. 1368 - 1373. 4. 71. 2014. 10.1002/mrm.24789 . Magnetic Resonance in Medicine
2H enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis
Delgado, T.C.; Martins, F.O.; Carvalho, F.; Gonçalves, A.; Scott, D.K.; O'Doherty, R.; Paula Macedo, M.; Jones, J.G., 2013. American Journal of Physiology - Endocrinology and Metabolism. 4. 304. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874073240&partnerID=MN8TOARS . 10.1152/ajpendo.00185.2012 . American Journal of Physiology - Endocrinology and Metabolism
Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes
Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita, 2013. American Journal of Physiology-Endocrinology and Metabolism. E465 - E474. 4. 305. 2013. 10.1152/ajpendo.00245.2013 . American Journal of Physiology-Endocrinology and Metabolism
Disposition of [U-(2)H7]glucose into hepatic glycogen in rat and in seabass.
Martins, Fatima O; Rito, Joao; Jarak, Ivana; Viegas, Ivan; Pardal, Miguel A; Macedo, M Paula; Jones, John G, 2013. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 316 - 22. 2. 166. 2013. 10.1016/j.cbpa.2013.07.002 . Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.)
Viegas, I.; Rito, J.; González, J.D.; Jarak, I.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2013. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 399 - 405. 3. 166. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882801986&partnerID=MN8TOARS . 10.1016/j.cbpa.2013.07.013 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Noninvasive measurement of murine hepatic acetyl-CoA C 13 -enrichment following overnight feeding with C 13 -enriched fructose and glucose
Carvalho, F.; Duarte, J.; Simoes, A.R.; Cruz, P.F.; Jones, J.G., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880126867&partnerID=MN8TOARS . 10.1155/2013/638085 . BioMed Research International
Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia
Basu, Rita; Barosa, Cristina; Jones, John; Dube, Simmi; Carter, Rickey; Basu, Ananda; Rizza, Robert A., 2013. Journal of Clinical Endocrinology & Metabolism. E409 - E417. 3. 98. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000316417200001&KeyUID=CCC:000316417200001 . 10.1210/JC.2012-3056 . Journal of Clinical Endocrinology & Metabolism
Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method
Barosa, Cristina; Jones, John G.; Rizza, Robert; Basu, Ananda; Basu, Rita; Barosa, C.; Jones, J.G.; et al, 2013. Magnetic Resonance in Medicine. 315 - 319. 2. 70. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000322128300003&KeyUID=CCC:000322128300003 . 10.1002/mrm.24485 . Magnetic Resonance in Medicine
Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis
Reis, C.P.; Neufeld, R.; Veiga, F.; Figueiredo, I.V.; Jones, J.; Soares, A.F.; Nunes, P.; Damgé, C.; Carvalho, R.A., 2012. Journal of Microencapsulation. 167 - 176. 2. 29. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863418969&partnerID=MN8TOARS . 10.3109/02652048.2011.638992 . Journal of Microencapsulation
Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration
Soares, Ana F.; Carvalho, Rui A.; Veiga, Francisco J.; Alves, Marco G.; Martins, Fatima O.; Viegas, Ivan; Gonzalez, Juan D.; et al, 2012. American Journal of Physiology-Endocrinology and Metabolism. E875 - E885. 7. 303. 2012. 10.1152/ajpendo.00161.2012 . American Journal of Physiology-Endocrinology and Metabolism
Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation
Gonzalez, Juan D.; Caballero, Albert; Viegas, Ivan; Meton, Isidoro; Jones, John G.; Barra, Joana; Fernandez, Felipe; Baanante, Isabel V., 2012. British Journal of Nutrition. 1747 - 1756. 12. 107. 2012. 10.1017/S000711451100496X . British Journal of Nutrition
Role of entrapped vapor bubbles during microdroplet evaporation
Putnam, Shawn A.; Byrd, Larry W.; Briones, Alejandro M.; Hanchak, Michael S.; Ervin, Jamie S.; Jones, John G., 2012. Applied Physics Letters. 2012. https://publons.com/wos-op/publon/28925206/ . 10.1063/1.4745009 . Applied Physics Letters
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
Gomes, Ana P.; Duarte, Filipe V.; Nunes, Patricia; Hubbard, Basil P.; Teodoro, Joao S.; Varela, Ana T.; Jones, John G.; et al, 2012. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 185 - 195. 2. 1822. 2012. 10.1016/j.bbadis.2011.10.008 . Biochimica Et Biophysica Acta-Molecular Basis of Disease
Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes
Viegas, I.; Rito, J.; Jarak, I.; Leston, S.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G., 2012. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 22 - 29. 1. 163. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862836540&partnerID=MN8TOARS . 10.1016/j.cbpa.2012.04.023 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects
Barosa, Cristina; Silva, Claudia; Fagulha, Ana; Barros, Luísa; Caldeira, M. Madalena; Carvalheiro, Manuela; Jones, John G.; et al, 2012. Metabolism. 250 - 254. 2. 61. 2012. http://dx.doi.org/10.1016/j.metabol.2011.06.022 . 10.1016/j.metabol.2011.06.022 . Metabolism
Resolving the Sources of Plasma Glucose Excursions following a Glucose Tolerance Test in the Rat with Deuterated Water and [U-C-13]Glucose
Delgado, Teresa C.; Barosa, Cristina; Nunes, Patricia M.; Cerdan, Sebastian; Geraldes, Carlos F. G. C.; Jones, John G., 2012. Plos One. 3. 7. 2012. 10.1371/journal.pone.0034042 . Plos One
Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat
Delgado, T.C.; Barosa, C.; Nunes, P.M.; Scott, D.K.; O'Doherty, R.M.; Cerdán, S.; Geraldes, C.F.; Jones, J.G., 2012. Expert Opinion on Drug Metabolism and Toxicology. 1223 - 1230. 10. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866515605&partnerID=MN8TOARS . 10.1517/17425255.2012.709500 . Expert Opinion on Drug Metabolism and Toxicology
Glycated hemoglobin and associated risk factors in older adults
Martins, Raul A.; Jones, John G.; Cumming, Sean P.; Coelho e Silva, Manuel J.; Teixeira, Ana M.; Verissimo, Manuel T., 2012. Cardiovascular Diabetology. 11. 2012. 10.1186/1475-2840-11-13 . Cardiovascular Diabetology
Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water
Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052079316&partnerID=MN8TOARS . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Transaldolase exchange and its effects on measurements of gluconeogenesis in humans
Basu, Rita; Barosa, Cristina; Basu, Ananda; Pattan, Vishwanath; Saad, Ahmed; Jones, John; Rizza, Robert, 2011. American Journal of Physiology-Endocrinology and Metabolism. E296 - E303. 2. 300. 2011. http://dx.doi.org/10.1152/ajpendo.00403.2010 . 10.1152/ajpendo.00403.2010 . American Journal of Physiology-Endocrinology and Metabolism
2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine
Silva, A.M.; Martins, F.; Jones, J.G.; Carvalho, R., 2011. Magnetic Resonance in Medicine. 1526 - 1530. 6. 66. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355161597&partnerID=MN8TOARS . 10.1002/mrm.22955 . Magnetic Resonance in Medicine
Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes
Kacerovsky, M; Jones, J; Schmid, AI; Barosa, C; Lettner, A; Kacerovsky-Bielesz, G; Szendroedi, J; et al, 2011. Diabetes. 1752 - 1758. 6. 60. 2011. 10.2337/db10-1001 . Diabetes
Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes
Kacerovsky, M.; Brehm, A.; Chmelik, M.; Schmid, A.I.; Szendroedi, J.; Kacerovsky-Bielesz, G.; Nowotny, P.; et al, 2011. Journal of Internal Medicine. 189 - 199. 2. 269. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651069103&partnerID=MN8TOARS . 10.1111/j.1365-2796.2010.02298.x . Journal of Internal Medicine
Ursodeoxycholic acid treatment of hepatic steatosis: A 13C NMR metabolic study
Nunes, P.M.; Jones, J.G.; Rolo, A.P.; Palmeira, C.M.M.; Carvalho, R.A., 2011. NMR in Biomedicine. 1145 - 1158. 9. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054069550&partnerID=MN8TOARS . 10.1002/nbm.1672 . NMR in Biomedicine
Contribution of proteolytic and metabolic sources to hepatic glutamine by 2H NMR analysis of urinary phenylacetylglutamine 2H-enrichment from 2H2O
Barosa, C.; Almeida, M.; Caldeira, M.M.; Gomes, F.; Jones, J.G., 2010. Metabolic Engineering. 53 - 61. 1. 12. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449718782&partnerID=MN8TOARS . 10.1016/j.ymben.2009.08.009 . Metabolic Engineering
Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis
Soares, Ana F.; Carvalho, Rui A.; Veiga, Francisco J.; Jones, John G., 2010. Metabolic Engineering. 552 - 560. 6. 12. 2010. http://dx.doi.org/10.1016/j.ymben.2010.08.002 . 10.1016/j.ymben.2010.08.002 . Metabolic Engineering
Quantifying endogenous glucose production and contributing source fluxes from a single <sup>2</sup>H NMR spectrum
Nunes, Patricia M.; Jones, John G., 2009. Magnetic Resonance in Medicine. 802 - 807. 3. 62. 2009. http://dx.doi.org/10.1002/mrm.22062 . 10.1002/mrm.22062 . Magnetic Resonance in Medicine
Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat
Delgado, T.C.; Pinheiro, D.; Caldeira, M.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; López-Larrubia, P.; Cerdán, S.; Jones, J.G., 2009. NMR in Biomedicine. 310 - 317. 3. 22. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64949105862&partnerID=MN8TOARS . 10.1002/nbm.826 . NMR in Biomedicine
Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease
Jones, John G.; Garcia, Paula; Barosa, Cristina; Delgado, Teresa C.; Diogo, Luisa, 2009. Metabolic Engineering. 155 - 162. 3. 11. 2009. http://dx.doi.org/10.1016/j.ymben.2009.01.003 . 10.1016/j.ymben.2009.01.003 . Metabolic Engineering
Sources of hepatic glycogen synthesis during an oral glucose tolerance test: Effect of transaldolase exchange on flux estimates
Delgado, Teresa C.; Silva, Claúdia; Fernandes, Isabel; Caldeira, Madalena; Bastos, Margarida; Baptista, Carla; Carvalheiro, Manuela; Geraldes, Carlos F. G. C.; Jones, John G., 2009. Magnetic Resonance in Medicine. 1120 - 1128. 5. 62. 2009. http://dx.doi.org/10.1002/mrm.22107 . 10.1002/mrm.22107 . Magnetic Resonance in Medicine
Toxicological assessment of orally delivered nanoparticulate insulin
Reis, Catarina P.; Figueiredo, Isabel V.; Carvalho, Rui A.; Jones, John; Nunes, Patricia; Soares, Ana F.; Silva, Cristina F.; et al, 2008. Nanotoxicology. 205 - 217. 4. 2. 2008. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207480800003&KeyUID=WOS:000207480800003 . 10.1080/17435390802398309 . Nanotoxicology
Elimination of glucose contamination from adipocyte glycogen extracts
Nunes, P.M.; Carvalho, E.; Jones, J.G., 2008. Carbohydrate Research. 1486 - 1489. 9. 343. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS . 10.1016/j.carres.2008.04.004 . Carbohydrate Research
Sources of hepatic glucose production by <sup>2</sup>H<sub>2</sub>O ingestion and Bayesian analysis of <sup>2</sup>H glucuronide enrichment
Delgado, T.C.; Barosa, C.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Bastos, M.; Baptista, C.; Fagulha, A.; et al, 2008. Magnetic Resonance in Medicine. 517 - 523. 3. 60. 2008. http://dx.doi.org/10.1002/mrm.21681 . 10.1002/mrm.21681 . Magnetic Resonance in Medicine
Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans
Jones, John G.; Garcia, Paula; Barosa, Cristina; Delgado, Teresa C.; Caldeira, M. Madalena; Diogo, Luisa, 2008. Magnetic Resonance in Medicine. 423 - 429. 2. 59. 2008. http://dx.doi.org/10.1002/mrm.21451 . 10.1002/mrm.21451 . Magnetic Resonance in Medicine
Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions
Soares, Ana F.; Viega, Francisco J.; Carvalho, Rui A.; Jones, John G., 2008. Magnetic Resonance in Medicine. 1 - 5. 1. 61. 2008. http://dx.doi.org/10.1002/mrm.21830 . 10.1002/mrm.21830 . Magnetic Resonance in Medicine
Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat
SENA, CM; BAROSA, C; NUNES, E; SEICA, R; JONES, JG, 2007. DIABETES & METABOLISM. 296 - 302. 33. 2007. 10.1016/j.diabet.2007.03.002 . DIABETES & METABOLISM
Toxicological in vivo studies of an oral insulin nanosystern
Reis, Catarina Pinto; Veiga, Francisco; Nunes, Patricia; Soares, Ana Francisca; Laranjeira, Tania; Carvalho, Rui; Jones, John; et al, 2007. Toxicology Letters. S90 - S90. 172. 2007. 10.1016/j.toxlet.2007.05.250 . Toxicology Letters
Estimating gluconeogenesis by NMR isotopomer distribution analysis of [<sup>13</sup>C]bicarbonate and [1-<sup>13</sup>C]lactate
Alves, Tiago Cardoso; Nunes, Patrícia Maria; Palmeira, Carlos Marques; Jones, John Griffith; Carvalho, Rui Albuquerque, 2007. NMR in Biomedicine. 337 - 344. 4. 21. 2007. http://dx.doi.org/10.1002/nbm.1195 . 10.1002/nbm.1195 . NMR in Biomedicine
Hepatic UDP-glucose <sup>13</sup>C isotopomers from [U-<sup>13</sup>C]glucose: A simple analysis by <sup>13</sup>C NMR of urinary menthol glucuronide
Mendes, Ana C.; Caldeira, M. Madalena; Silva, Claudia; Burgess, Shawn C.; Merritt, Matthew E.; Gomes, Filipe; Barosa, Cristina; et al, 2006. Magnetic Resonance in Medicine. 1121 - 1125. 5. 56. 2006. http://dx.doi.org/10.1002/mrm.21057 . 10.1002/mrm.21057 . Magnetic Resonance in Medicine
Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution <sup>1</sup>H NMR spectroscopy
Duarte, Iola F.; Goodfellow, Brian J.; Barros, António; Jones, John G.; Barosa, Cristina; Diogo, Luisa; Garcia, Paula; Gil, Ana M., 2006. NMR in Biomedicine. 401 - 412. 4. 20. 2006. http://dx.doi.org/10.1002/nbm.1073 . 10.1002/nbm.1073 . NMR in Biomedicine
NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers
Jones, J.; Barosa, C.; Gomes, F.; Carina Mendes, A.; Delgado, T.; Diogo, L.; Garcia, P.; et al, 2006. Journal of Carbohydrate Chemistry. 203 - 217. 2-3. 25. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745133402&partnerID=MN8TOARS . 10.1080/07328300600732840 . Journal of Carbohydrate Chemistry
Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen
Jones, John G.; Fagulha, Ana; Barosa, Cristina; Bastos, Margarida; Barros, Luisa; Baptista, Carla; Caldeira, M. Madalena; Carvalheiro, Manuela, 2006. Diabetes. 2294 - 2300. 8. 55. 2006. http://dx.doi.org/10.2337/db06-0304 . 10.2337/db06-0304 . Diabetes
Simple measurement of gluconeogenesis by direct <sup>2</sup>H NMR analysis of menthol glucuronide enrichment from <sup>2</sup>H<sub>2</sub>O
Ribeiro, Angela; Caldeira, M. Madalena; Carvalheiro, Manuela; Bastos, Margarida; Baptista, Carla; Fagulha, Ana; Barros, Luisa; Barosa, Cristina; Jones, John G., 2005. Magnetic Resonance in Medicine. 429 - 434. 2. 54. 2005. http://dx.doi.org/10.1002/mrm.20567 . 10.1002/mrm.20567 . Magnetic Resonance in Medicine
Comparison of [3,4-<sup>13</sup>C<sub>2</sub>]glucose to [6,6-<sup>2</sup>H<sub>2</sub>]glucose as a tracer for glucose turnover by nuclear magnetic resonance
Jin, Eunsook S.; Jones, John G.; Burgess, Shawn C.; Merritt, Matthew E.; Dean Sherry, A.; Malloy, Craig R., 2005. Magnetic Resonance in Medicine. 1479 - 1483. 6. 53. 2005. http://dx.doi.org/10.1002/mrm.20496 . 10.1002/mrm.20496 . Magnetic Resonance in Medicine
Uptake and metabolic effects of insulin mimetic oxovanadium compounds in human erythrocytes
Delgado, T.C.; Tomaz, A.I.; Correia, I.; Costa Pessoa, J.; Jones, J.G.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Journal of Inorganic Biochemistry. 2328 - 2339. 12. 99. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28544439916&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2005.08.014 . Journal of Inorganic Biochemistry
Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis
Fonseca, C.P.; Jones, J.G.; Carvalho, R.A.; Jeffrey, F.M.H.; Montezinho, L.P.; Geraldes, C.F.G.C.; Castro, M.M.C.A., 2005. Neurochemistry International. 385 - 393. 6. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24144491138&partnerID=MN8TOARS . 10.1016/j.neuint.2005.06.005 . Neurochemistry International
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
JIN, ES; JONES, JG; MERRITT, M; BURGESS, SC; MALLOY, CR; SHERRY, AD, 2004. ANALYTICAL BIOCHEMISTRY. 149 - 155. 2. 327. 2004. 10.1006/abio.1998.2796 . ANALYTICAL BIOCHEMISTRY
Quantitation of erythrocyte pentose pathway flux with [2-<sup>13</sup>C]glucose and <sup>1</sup>H NMR analysis of the lactate methyl signal
Delgado, Teresa C.; Castro, M. Margarida; Geraldes, Carlos F.; Jones, John G., 2004. Magnetic Resonance in Medicine. 1283 - 1286. 6. 51. 2004. http://dx.doi.org/10.1002/mrm.20096 . 10.1002/mrm.20096 . Magnetic Resonance in Medicine
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine
Burgess, Shawn C; Weis, Brian; Jones, John G; Smith, Erin; Merritt, Matthew E; Margolis, David; Dean Sherry, A; Malloy, Craig R, 2003. Analytical Biochemistry. 228 - 234. 2. 312. 2003. http://dx.doi.org/10.1016/s0003-2697(02)00465-7 . 10.1016/s0003-2697(02)00465-7 . Analytical Biochemistry
Sources of glucose production in cirrhosis by (H2O)-H-2 ingestion and H-2 NMR analysis of plasma glucose
PERDIGOTO, R; FURTADO, AL; PORTO, A; RODRIGUES, TB; GERALDES, CFGC; JONES, JG, 2003. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 156 - 163. 2. 1637. 2003. 10.1016/S0925-4439(03)00018-8 . BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Integration of [U-<sup>13</sup>C]glucose and <sup>2</sup>H<sub>2</sub>O for quantification of hepatic glucose production and gluconeogenesis
Perdigoto, Rui; Rodrigues, Tiago B.; Furtado, Alexandre L.; Porto, Armando; Geraldes, Carlos F. G. C.; Jones, John G., 2003. NMR in Biomedicine. 189 - 198. 4. 16. 2003. http://dx.doi.org/10.1002/nbm.826 . 10.1002/nbm.826 . NMR in Biomedicine
Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl<sub>4</sub> model of acute liver failure
Carvalho, Rui A.; Jones, John G.; McGuirk, Chris; Sherry, A. Dean; Malloy, Craig R., 2002. NMR in Biomedicine. 45 - 51. 1. 15. 2002. http://dx.doi.org/10.1002/nbm.745 . 10.1002/nbm.745 . NMR in Biomedicine
Quantitation of absolute <sup>2</sup>H enrichment of plasma glucose by <sup>2</sup>H NMR analysis of its monoacetone derivative
Jones, John G.; Perdigoto, Rui; Rodrigues, Tiago B.; Geraldes, Carlos F.G.C., 2002. Magnetic Resonance in Medicine. 535 - 539. 3. 48. 2002. http://dx.doi.org/10.1002/mrm.10234 . 10.1002/mrm.10234 . Magnetic Resonance in Medicine
13C Isotopomer Analysis of Glutamate by J-Resolved Heteronuclear Single Quantum Coherence Spectroscopy
Burgess, Shawn C.; Carvalho, Rui A.; Merritt, Matthew E.; Jones, John G.; Malloy, Craig R.; Sherry, A.Dean, 2001. Analytical Biochemistry. 187 - 195. 2. 289. 2001. http://dx.doi.org/10.1006/abio.2000.4930 . 10.1006/abio.2000.4930 . Analytical Biochemistry
An integrated H-2 and C-13 NMR study of gluconeogenesis and TCA cycle flux in humans
Jones, JG; Solomon, MA; Cole, SM; Sherry, AD; Malloy, CR; Jones, J.G.; Solomon, M.A.; et al, 2001. American Journal of Physiology-Endocrinology and Metabolism. E848 - E856. 4. 281. 2001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171583200025&KeyUID=WOS:000171583200025 . 10.1152/AJPENDO.2001.281.4.E848 . American Journal of Physiology-Endocrinology and Metabolism
Quantitation of Gluconeogenesis by 2H Nuclear Magnetic Resonance Analysis of Plasma Glucose Following Ingestion of 2H2O
Jones, John G.; Carvalho, Rui A.; Sherry, A.Dean; Malloy, Craig R., 2000. Analytical Biochemistry. 121 - 126. 1. 277. 2000. http://dx.doi.org/10.1006/abio.1999.4391 . 10.1006/abio.1999.4391 . Analytical Biochemistry
Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
O'Doherty, RM; Jensen, PB; Anderson, P; Jones, JG; Berman, HK; Kearney, D; Newgard, CB; et al, 2000. Journal of Clinical Investigation. 479 - 488. 4. 105. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033995047&partnerID=MN8TOARS . 10.1172/JCI8673 . Journal of Clinical Investigation
Measurement of Hepatic Glucose Output, Krebs Cycle, and Gluconeogenic Fluxes by NMR Analysis of a Single Plasma Glucose Sample
Jones, John G.; Carvalho, Rui A.; Franco, Byron; Sherry, A.Dean; Malloy, Craig R., 1998. Analytical Biochemistry. 39 - 45. 1. 263. 1998. http://dx.doi.org/10.1006/abio.1998.2796 . 10.1006/abio.1998.2796 . Analytical Biochemistry
13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen
Jones, J.G.; Solomon, M.A.; Dean Sherry, A.; Jeffrey, F.M.H.; Malloy, C.R.; Jones, JG; Solomon, MA; et al, 1998. American Journal of Physiology - Endocrinology and Metabolism. E843 - E852. 5 38-5. 275. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032209269&partnerID=MN8TOARS . 10.1152/AJPENDO.1998.275.5.E843 . American Journal of Physiology - Endocrinology and Metabolism
Determination of Acetyl-CoA Enrichment in Rat Heart and Skeletal Muscle by1H Nuclear Magnetic Resonance Analysis of Glutamate in Tissue Extracts
Jones, John G.; Hansen, Jim; Sherry, A.Dean; Malloy, Craig R.; Victor, Ronald G., 1997. Analytical Biochemistry. 201 - 206. 2. 249. 1997. http://dx.doi.org/10.1006/abio.1997.2172 . 10.1006/abio.1997.2172 . Analytical Biochemistry
Oxidation of lactate and acetate in rat skeletal muscle: Analysis by 13C-nuclear magnetic resonance spectroscopy
Bertocci, L.A.; Jones, J.G.; Malloy, C.R.; Victor, R.G.; Thomas, G.D.; Bertocci, LA; Jones, JG; et al, 1997. Journal of Applied Physiology. 32 - 39. 1. 83. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030844432&partnerID=MN8TOARS . 10.1152/JAPPL.1997.83.1.32 . Journal of Applied Physiology
Measurement of gluconeogenesis and pyruvate recycling in the rat liver: A simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate
Jones, J.G.; Naidoo, R.; Sherry, A.D.; Jeffrey, F.M.H.; Cottam, G.L.; Malloy, C.R., 1997. FEBS Letters. 131 - 137. 1. 412. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030754203&partnerID=MN8TOARS . 10.1016/S0014-5793(97)00764-3 . FEBS Letters
Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts
JONES, JG; LE, TH; STOREY, CJ; SHERRY, AD; MALLOY, CR; BURTON, KP, 1996. FREE RADICAL BIOLOGY AND MEDICINE. 515 - 523. 4. 20. 1996. 10.1016/0891-5849(95)02088-8 . FREE RADICAL BIOLOGY AND MEDICINE
Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by C-13 isotopomer analysis and O-2 consumption in the heart
MALLOY, CR; JONES, JG; JEFFREY, FM; JESSEN, ME; SHERRY, AD, 1996. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 35 - 46. 1. 4. 1996. 10.1007/BF01759778 . MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Orientation-conserved transfer of symmetric krebs cycle intermediates in mammalian tissue
Sherry, A.D.; Sumegi, B.; Miller, B.; Cottam, G.L.; Gavva, S.; Jones, J.G.; Malloy, C.R.; et al, 1994. Biochemistry. 6268 - 6275. 20. 33. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028356902&partnerID=MN8TOARS . 10.1021/bi00186a029 . Biochemistry
A Method for Obtaining 13C Isotopomer Populations in 13C-Enriched Glucose
Jones, J.G.; Cottam, G.L.; Miller, B.C.; Sherry, A.D.; Malloy, C.R., 1994. Analytical Biochemistry. 148 - 152. 1. 217. 1994. http://dx.doi.org/10.1006/abio.1994.1095 . 10.1006/abio.1994.1095 . Analytical Biochemistry
EFFECTS OF OXIDANT EXPOSURE ON SUBSTRATE UTILIZATION AND HIGH-ENERGY PHOSPHATES IN ISOLATED RAT HEARTS
BURTON, KP; JONES, JG; LE, TH; SHERRY, AD; MALLOY, CR, 1994. Circulation Research. 97 - 104. 1. 75. 1994. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994NV03100012&KeyUID=WOS:A1994NV03100012 . 10.1161/01.RES.75.1.97 . Circulation Research
Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers
Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R.; JONES, JG; SHERRY, AD; et al, 1993. Biochemistry. 12240 - 12244. 45. 32. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027359228&partnerID=MN8TOARS . 10.1021/bi00096a037 . Biochemistry
METHYLAMINE METABOLISM IN HANSENULA-POLYMORPHA - AN INVIVO C-13 AND P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY
JONES, JG; BELLION, E, 1991. JOURNAL OF BACTERIOLOGY. 4959 - 4969. 16. 173. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GB01400007&KeyUID=WOS:A1991GB01400007 . 10.1128/JB.173.16.4959-4969.1991 . JOURNAL OF BACTERIOLOGY
INVIVO C-13 AND N-15 NMR-STUDIES OF METHYLAMINE METABOLISM IN PSEUDOMONAS SPECIES MA
JONES, JG; BELLION, E, 1991. JOURNAL OF BIOLOGICAL CHEMISTRY. 11705 - 11713. 18. 266. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991FT76200046&KeyUID=WOS:A1991FT76200046 . JOURNAL OF BIOLOGICAL CHEMISTRY
METHANOL OXIDATION AND ASSIMILATION IN HANSENULA-POLYMORPHA - AN ANALYSIS BY C-13 NMR INVIVO
JONES, JG; BELLION, E, 1991. BIOCHEMICAL JOURNAL. 475 - 481. 280. 1991. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GU90100031&KeyUID=WOS:A1991GU90100031 . 10.1042/BJ2800475 . BIOCHEMICAL JOURNAL
5 135 out of 135 Publications
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