Neurociências e Doença
Neuromodulação
Receptores de adenosina
Envelhecimento
Doenças do cérebro
Cafeína
Neuroprotecção
Receptores de adenosina
Envelhecimento
Doenças do cérebro
Cafeína
Neuroprotecção
Uma função cerebral adequada depende do equilíbrio entre sinapses excitatórias e inibitórias, as quais são reguladas por sistemas neuro-moduladores. O trabalho desenvolvido por este grupo é inspirado pelo impacto da cafeína, o principal componente do café, no aumento do estado de atenção, na normalização da memória e do humor, no aumento da esperança de vida e envelhecimento ativo e na sua capacidade de impedir o aparecimento de diferentes distúrbios neurodegenerativos (doenças de Alzheimer e de Parkinson).Assim, o objetivo do grupo é estudar os sistemas de neuro-modulação operados por purinas (adenosina e ATP), conhecidas por serem alvo da cafeína, para dessa forma interferir na evolução de doenças neurodegenerativas. Identificámos os recetores A2A da adenosina (A2AR) como os principais alvos da cafeína no controlo de distúrbios cerebrais, usando uma combinação de ferramentas farmacológicas, genéticas e opto-genéticas. Estabelecemos que os A2AR são necessários e suficientes para desencadear sintomas em diferentes modelos animais de doenças de Alzheimer ou Parkinson, depressão, epilepsia ou encefalopatia diabética, por meio de uma capacidade combinada de restaurar a plasticidade sináptica, controlar a neuroinflamação e reforçar o suporte metabólico pelos astrócitos.
O grupo tem diferentes animais (murganhos) transgénicos e modelos de doenças cerebrais induzidas farmacologicamente, bem como um conjunto de ferramentas para interferir com o A2AR (murganhos transgénicos “cel Specific” e sistemas mediados por vírus para reforçar ou diminuir a função dos A2AR) e acesso a tecido cerebral humano.
Seguimos uma abordagem holística das questões científicas, agregando a nossa experiência em: i) estudos de comportamento animal que avaliam aprendizagem e memória, desempenho motor, alterações de humor e processamento do medo; ii) cirurgia cerebral estereotáxica; iii) estudos eletrofisiológicos ex vivo (fatias do cérebro) para avaliar a função de circuitos cerebrais (registros extracelulares) e correntes iónicas (patch-clamp); iv) imagiologia de alterações funcionais (“cell live Ca2+”), morfológicas (histoquímica) e neuroquímicas (ligação, tráfico e expressão de receptotres), combinando técnicas de radioligandos, FRET, ensaio de ligação por proximidade, PCR e de Western blot); v) fracionamento sub-celular de sinaptossomas e gliossomas e uso de culturas celulares (neurónios e astrócitos) para estudar a liberação e captação de neurotransmissores.
O grupo tem um histórico de mais de 250 publicações em revistas científicas com alto fator de impacto, com mais de 12.000 citações e um fator h de 62, com base em inúmeras colaborações em todo o mundo. O grupo tem uma vasta experiência em treino de pós-graduação (mais de 15 estudantes de pós-doutoramento, 40 de doutoramento e 25 de mestrado), com financiamentos obtidos de agências americanas e europeias, bem como de empresas privadas e farmacêuticas.
Informação sobre artigos em revista, actualizada a 17-11-2024, a partir da plataforma CIÊNCIAVITAE.
40 Hz light flickering promotes sleep through cortical adenosine signaling
Zhou, Xuzhao; He, Yan; Xu, Tao; Wu, Zhaofa; Guo, Wei; Xu, Xi; Liu, Yuntao; et al, 2024. Cell Research. 2024. http://dx.doi.org/10.1038/s41422-023-00920-1 . 10.1038/s41422-023-00920-1 . accepted Cell Research
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al, 2024. Molecular Psychiatry. 2024. http://dx.doi.org/10.1038/s41380-024-02412-z . 10.1038/s41380-024-02412-z . accepted Molecular Psychiatry
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation
Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes, 2023. Biomolecules. 2023. https://doi.org/10.3390/biom13040715 . 10.3390/biom13040715 . Biomolecules
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease
Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes, 2023. Biomolecules. 2023. https://doi.org/10.3390/biom13081173 . 10.3390/biom13081173 . Biomolecules
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas
Cátia R. Lopes; Andreia Oliveira; Ingride Luzio Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al, 2023. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/1/106 . 10.3390/biom13010106 . Biomolecules
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors
Pedro Valada; Sonja Hinz; Christin Vielmuth; Cátia R. Lopes; Rodrigo A. Cunha; Christa E. Müller; João Pedro Lopes, 2023. Purinergic Signalling. 2023. https://doi.org/10.1007/s11302-022-09899-7 . 10.1007/s11302-022-09899-7 . Purinergic Signalling
Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice
Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2023. Glia. 2023. https://doi.org/10.1002/glia.24384 . 10.1002/glia.24384 . Glia
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress
Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; et al, 2023. ACS Chemical Neuroscience. 1299 - 1309. 7. 14. 2023. http://dx.doi.org/10.1021/acschemneuro.2c00810 . 10.1021/acschemneuro.2c00810 . published ACS Chemical Neuroscience
Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors
Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2023. Cellular and Molecular Life Sciences. 2023. https://doi.org/10.1007/s00018-023-04983-6 . 10.1007/s00018-023-04983-6 . Cellular and Molecular Life Sciences
Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula
Wang, Muran; Li, Peijun; Li, Zewen; da Silva, Beatriz S.; Zheng, Wu; Xiang, Zhenghua; He, Yan; et al, 2023. Nature Communications. 1. 14. 2023. http://dx.doi.org/10.1038/s41467-023-37601-x . 10.1038/s41467-023-37601-x . published Nature Communications
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease
Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al, 2023. International Journal of Molecular Sciences. 8. 24. 2023. http://dx.doi.org/10.3390/ijms24086968 . 10.3390/ijms24086968 . published International Journal of Molecular Sciences
Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices
Fernandes, Mara Yone D.; Lopes, João Pedro; Silva, Henrique B.; Andrade, Geanne M.; Cunha, Rodrigo A.; Tomé, Angelo R., 2023. Neuroscience Letters. 808. 2023. http://dx.doi.org/10.1016/j.neulet.2023.137292 . 10.1016/j.neulet.2023.137292 . published Neuroscience Letters
Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest
Picó-Pérez, Maria; Magalhães, Ricardo; Esteves, Madalena; Vieira, Rita; Castanho, Teresa C.; Amorim, Liliana; Sousa, Mafalda; et al, 2023. Frontiers in Behavioral Neuroscience. 17. 2023. http://dx.doi.org/10.3389/fnbeh.2023.1176382 . 10.3389/fnbeh.2023.1176382 . published Frontiers in Behavioral Neuroscience
Targeting corticostriatal transmission for the treatment of cannabinoid use disorder
Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis, 2023. Trends in Pharmacological Sciences. 495 - 506. 8. 44. 2023. http://dx.doi.org/10.1016/j.tips.2023.05.003 . 10.1016/j.tips.2023.05.003 . Trends in Pharmacological Sciences
Adenosine A2A receptors control generalization of contextual fear in rats
Simões, Ana P.; Portes, Marina A. M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; et al, 2023. Translational Psychiatry. 1. 13. 2023. http://dx.doi.org/10.1038/s41398-023-02613-0 . 10.1038/s41398-023-02613-0 . published Translational Psychiatry
Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals
Gonçalves, Francisco Q.; Valada, Pedro; Matos, Marco; Cunha, Rodrigo A.; Tomé, Angelo R., 2023. Purinergic Signalling. 2023. http://dx.doi.org/10.1007/s11302-023-09937-y . 10.1007/s11302-023-09937-y . accepted Purinergic Signalling
The striatum drives the ergogenic effects of caffeine
Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al, 2023. Purinergic Signalling. 2023. https://doi.org/10.1007/s11302-023-09922-5 . 10.1007/s11302-023-09922-5 . Purinergic Signalling
Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons
Margarida Beatriz; Rodrigues, Ricardo J.; Rita Vilaça; Conceição Egas; Paulo S. Pinheiro; George Q. Daley; Thorsten M. Schlaeger; et al, 2023. Theranostics. 3707 - 3724. 11. 13. 2023. http://dx.doi.org/10.7150/thno.81981 . 10.7150/thno.81981 . published Theranostics
Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility
Jiang-Fan Chen; Doo-Sup Choi; Rodrigo A. Cunha, 2023. Neuropharmacology. 2023. https://doi.org/10.1016/j.neuropharm.2023.109421 . 10.1016/j.neuropharm.2023.109421 . Neuropharmacology
The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine
Bruno Gonçalves Pinheiro; Diandra Araújo Luz; Sabrina de Carvalho Cartágenes; Luanna de Melo Pereira Fernandes; Sarah Viana Farias; Natália Harumi Correa Kobayashi; Enéas Andrade Fontes-Júnior; et al, 2022. Pharmaceuticals. 2022. https://doi.org/10.3390/ph15111323 . 10.3390/ph15111323 . Pharmaceuticals
Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome
Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update
IJzerman, Adriaan P.; Jacobson, Kenneth A.; Müller, Christa E.; Cronstein, Bruce N.; Cunha, Rodrigo A., 2022. Pharmacological Reviews. 340 - 372. 2. 74. 2022. http://dx.doi.org/10.1124/pharmrev.121.000445 . 10.1124/pharmrev.121.000445 . published Pharmacological Reviews
Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease
Carvalho da Silva, António M.; Lemos, Cristina; Silva, Henrique B.; Ferreira, Ildete L.; Tomé, Angelo R.; Rego, A. Cristina; Cunha, Rodrigo A., 2022. Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.835885 . 10.3389/fnagi.2022.835885 . published Frontiers in Aging Neuroscience
Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes
Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas, 2022. Purinergic Signalling. 2022. https://doi.org/10.1007/s11302-022-09864-4 . 10.1007/s11302-022-09864-4 . Purinergic Signalling
Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage
Pedro Valada; Sofia Alçada-Morais; Rodrigo A. Cunha; João Pedro Lopes, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms231810510 . 10.3390/ijms231810510 . International Journal of Molecular Sciences
Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes
Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho, 2022. Cellular and Molecular Life Sciences. 2022. https://doi.org/10.1007/s00018-022-04492-y . 10.1007/s00018-022-04492-y . Cellular and Molecular Life Sciences
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease
Gonçalves, Francisco Q.; Matheus, Filipe C.; Silva, Henrique B.; Real, Joana I.; Rial, Daniel; Rodrigues, Ricardo J.; Oses, Jean-Pierre; et al, 2022. Molecular Neurobiology. 1659 - 1674. 3. 60. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . accepted Molecular Neurobiology
Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity
Lígia Fão; Patrícia Coelho; Rodrigues, Ricardo J.; A. Cristina Rego, 2022. Cells. 2022. https://doi.org/10.3390/cells11193063 . 10.3390/cells11193063 . Cells
CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity
Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Rodrigo A. Cunha, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232112826 . 10.3390/ijms232112826 . International Journal of Molecular Sciences
Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome
Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease
Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Rodrigues, Ricardo J.; Jean-Pierre Oses; et al, 2022. Molecular Neurobiology. 2022. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . Molecular Neurobiology
Adenosine A2A receptors control synaptic remodeling in the adult brain
Rodrigues, Ricardo J.; Joana M Marques, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription
Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; et al, 2022. Journal of Clinical Investigation. 12. 132. 2022. http://dx.doi.org/10.1172/jci149371 . 10.1172/jci149371 . published Journal of Clinical Investigation
Adenosine A2A receptors control synaptic remodeling in the adult brain
Xu, Xinli; Beleza, Rui O.; Gonçalves, Francisco Q.; Valbuena, Sergio; Alçada-Morais, Sofia; Gonçalves, Nélio; Magalhães, Joana; et al, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . published Scientific Reports
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects
Dewaeles, Edmone; Carvalho, Ke´vin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; et al, 2022. Journal of Clinical Investigation. 22. 132. 2022. http://dx.doi.org/10.1172/jci152924 . 10.1172/jci152924 . published Journal of Clinical Investigation
Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure
Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho, 2022. Journal of Neurochemistry. 2022. https://doi.org/10.1111/jnc.15575 . 10.1111/jnc.15575 . Journal of Neurochemistry
P2Y1 Receptor as a Catalyst of Brain Neurodegeneration
Rodrigues, Ricardo J.; Ana S. Figueira; Joana M. Marques, 2022. NeuroSci. 604 - 615. 3. 2022. https://doi.org/10.3390/neurosci3040043 . 10.3390/neurosci3040043 . published NeuroSci
Convergence of adenosine and GABA signaling for synapse stabilization during development
Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, 2021. Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . published Science
Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade
Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, 2021. Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology
Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.
Rodrigues, Ricardo J.; Joana M Marques, 2021. Cerebral cortex (New York, N.Y. : 1991). 5652 - 5663. 12. 31. 2021. https://doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral cortex (New York, N.Y. : 1991)
Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease
Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, Paula, 2021. Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.666710 . 10.3389/fnins.2021.666710 . Frontiers in Neuroscience
Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.
Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology
Binge-Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood
Cristiane do Socorro Ferraz Maia; Letícia Yoshitome Queiroz; Igor Gonçalves Oliveira; Carla Cristiane Soares Silva; Rodrigo A. Cunha; Deiweson Souza-Monteiro; Maria Karolina Martins Ferreira; et al, 2021. Alcoholism: Clinical and Experimental Research. 56 - 63. 1. 45. 2021. https://doi.org/10.1111/acer.14501 . 10.1111/acer.14501 . Alcoholism: Clinical and Experimental Research
Adenosine A2A Receptors as Biomarkers of Brain Diseases
Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A., 2021. Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.702581 . 10.3389/fnins.2021.702581 . Frontiers in Neuroscience
l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory
Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al, 2021. The FASEB Journal. 8. 35. 2021. https://doi.org/10.1096/fj.202100336R . 10.1096/fj.202100336R . The FASEB Journal
Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A. A.; Porciúncula, Lisiane O.; et al, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-89964-0 . 10.1038/s41598-021-89964-0 . Scientific Reports
Clustering of adenosine A<sub>2B</sub>receptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by<i>Leishmania amazonensis</i>
Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al, 2021. The FASEB Journal. 5. 35. 2021. http://dx.doi.org/10.1096/fj.202002396rr . 10.1096/fj.202002396rr . published The FASEB Journal
Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation
Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al, 2021. Cerebral Cortex. 5652 - 5663. 12. 31. 2021. http://dx.doi.org/10.1093/cercor/bhab188 . 10.1093/cercor/bhab188 . published Cerebral Cortex
Deletion of CD73 increases exercise power in mice
Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A., 2021. Purinergic Signalling. 393 - 397. 3. 17. 2021. http://dx.doi.org/10.1007/s11302-021-09797-4 . 10.1007/s11302-021-09797-4 . published Purinergic Signalling
Exercise decreases aberrant corticostriatal plasticity in an animal model of <scp>l</scp>-DOPA-induced dyskinesia
Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Ângelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D., 2021. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. R541 - R546. 4. 320. 2021. http://dx.doi.org/10.1152/ajpregu.00295.2020 . 10.1152/ajpregu.00295.2020 . published American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Use of knockout mice to explore CNS effects of adenosine
Lopes, Cátia R.; Lourenço, Vanessa S.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula M., 2021. Biochemical Pharmacology. 187. 2021. http://dx.doi.org/10.1016/j.bcp.2020.114367 . 10.1016/j.bcp.2020.114367 . published Biochemical Pharmacology
Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction
Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al, 2021. Neurobiology of Disease. 157. 2021. http://dx.doi.org/10.1016/j.nbd.2021.105441 . 10.1016/j.nbd.2021.105441 . published Neurobiology of Disease
Convergence of adenosine and GABA signaling for synapse stabilization during development
Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, 2021. Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . Science
Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides
Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho, 2021. Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-021-02538-z . 10.1007/s12035-021-02538-z . Molecular Neurobiology
Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress
Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A., 2021. Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.639322 . 10.3389/fncel.2021.639322 . published Frontiers in Cellular Neuroscience
Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape
Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa, 2021. Frontiers in Cellular and Infection Microbiology. 11. 2021. http://dx.doi.org/10.3389/fcimb.2021.678568 . 10.3389/fcimb.2021.678568 . Frontiers in Cellular and Infection Microbiology
Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome
Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, 2020. Neurobiology of Disease. 105137 - 105137. 146. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of Disease
Purinergic signaling orchestrating neuron-glia communication
Agostinho, Paula; Madeira, Daniela; Dias, Liliana; Simões, Ana Patrícia; Cunha, Rodrigo A.; Canas, Paula M., 2020. Pharmacological Research. 162. 2020. http://dx.doi.org/10.1016/j.phrs.2020.105253 . 10.1016/j.phrs.2020.105253 . published Pharmacological Research
Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder
de Santana Souza, Lisiane; de Siqueira, Priscila Albuquerque; Fernandes, Arlete; Silva Martins, Robertta; Cussa Kubrusly, Regina Célia; Paes-de-Carvalho, Roberto; Cunha, Rodrigo A.; dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo, 2020. Neuroscience. 140 - 148. 448. 2020. http://dx.doi.org/10.1016/j.neuroscience.2020.09.030 . 10.1016/j.neuroscience.2020.09.030 . published Neuroscience
The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease
Cunha, Rodrigo, 2020. Purinergic Signalling. 2020. http://dx.doi.org/10.1007/s11302-020-09694-2 . 10.1007/s11302-020-09694-2 . Purinergic Signalling
Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities
Cunha, Rodrigo, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . European Journal of Neuroscience
The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation
Nehlig, Astrid; Cunha, Rodrigo, 2020. Nutrients. 10. 12. 2020. http://dx.doi.org/10.3390/nu12103141 . 10.3390/nu12103141 . published Nutrients
Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice
Mack, Josiel Mileno; de Menezes Moura, Tainara; Bobinski, Franciane; Martins, Daniel Fernandes; Cunha, Rodrigo A.; Walz, Roger; Fernandes, Pedro Augusto; et al, 2020. NeuroToxicology. 144 - 154. 80. 2020. http://dx.doi.org/10.1016/j.neuro.2020.07.008 . 10.1016/j.neuro.2020.07.008 . NeuroToxicology
ATP Signaling Controlling Dyskinesia Through P2X7 Receptors
Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M., 2020. Frontiers in Molecular Neuroscience. 13. 2020. http://dx.doi.org/10.3389/fnmol.2020.00111 . 10.3389/fnmol.2020.00111 . published Frontiers in Molecular Neuroscience
Role of Adenosine in Epilepsy and Seizures
Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Angelo R. Tomé; Cunha, Rodrigo A.; Ana M. Sebastião; Boison, Detlev, 2020. Journal of Caffeine and Adenosine Research. 45 - 60. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0022 . 10.1089/caff.2019.0022 . Journal of Caffeine and Adenosine Research
Control of NMDA Receptor-Mediated Currents by Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors Within the Basolateral Amygdala
Pliássova, Anna; Henriques, Margarida; Silva, Henrique B.; Agostinho, Paula; Cunha, Rodrigo A.; Ferreira, Samira G., 2020. Journal of Caffeine and Adenosine Research. 61 - 70. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0024 . 10.1089/caff.2019.0024 . published Journal of Caffeine and Adenosine Research
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi, 2020. European Journal of Neuroscience. 2020. https://doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . published Brain Research Bulletin
Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder
França, Angela Patricia; Schamne, Marissa Giovanna; de Souza, Bruna Soares; da Luz Scheffer, Débora; Bernardelli, Angelica Karina; Corrêa, Thiago; de Souza Izídio, Geison; et al, 2020. Molecular Neurobiology. 3902 - 3919. 9. 57. 2020. http://dx.doi.org/10.1007/s12035-020-02002-4 . 10.1007/s12035-020-02002-4 . published Molecular Neurobiology
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Cunha, Rodrigo, 2020. BMC Biology. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology
The Yin and Yang of Adenosine Receptors: A Piquant Story
Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration
Rodrigo A Cunha, 2019. Brain. 2019. https://doi.org/10.1093/brain/awz335 . 10.1093/brain/awz335 . Brain
Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease
Cunha, Rodrigo, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14771 . 10.1111/bph.14771 . British Journal of Pharmacology
Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus
Sara L. Reis; Henrique B. Silva; Margarida Almeida; Rodrigo A. Cunha; Ana P. Simões; Paula M. Canas, 2019. Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14816 . 10.1111/jnc.14816 . Journal of Neurochemistry
Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine
Cunha, Rodrigo, 2019. Neurobiology of Disease. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism
Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology
Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders
Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Rodrigues, Ricardo J.; Sara Xapelli, 2019. Journal of Caffeine and Adenosine Research. 129 - 144. 4. 9. 2019. https://doi.org/10.1089%2Fcaff.2019.0010 . 10.1089/caff.2019.0010 . published Journal of Caffeine and Adenosine Research
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve
Cunha, Rodrigo, 2019. Molecules. 2019. http://dx.doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules
Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats
Cunha, Rodrigo, 2019. Glia. 2019. http://dx.doi.org/10.1002/glia.23476 . 10.1002/glia.23476 . Glia
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus
Cunha, Rodrigo, 2019. Frontiers in Neuroscience. 2019. http://dx.doi.org/10.3389/fnins.2018.01015 . 10.3389/fnins.2018.01015 . Frontiers in Neuroscience
Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice
Xavier Morató; Francisco Q. Gonçalves; João P. Lopes; Olga Jauregui; Concepció Soler; Víctor Fernández-Dueñas; Rodrigo A. Cunha; Francisco Ciruela, 2019. Journal of Neurochemistry. 796 - 809. 6. 148. 2019. https://doi.org/10.1111/jnc.14653 . 10.1111/jnc.14653 . Journal of Neurochemistry
Treadmill Exercise Attenuates l-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice
Cunha, Rodrigo, 2019. Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1278-3 . 10.1007/s12035-018-1278-3 . Molecular Neurobiology
Signaling by adenosine receptors—Homeostatic or allostatic control?
Rodrigo A. Cunha, 2019. PLOS Biology. e3000213 - e3000213. 4. 17. 2019. https://doi.org/10.1371/journal.pbio.3000213 . 10.1371/journal.pbio.3000213 . PLOS Biology
Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors
Cunha, Rodrigo, 2019. Molecular Neurobiology. 2019. http://dx.doi.org/10.1007/s12035-018-1296-1 . 10.1007/s12035-018-1296-1 . Molecular Neurobiology
What is the extracellular calcium concentration within brain synapses?
João Pedro Lopes; Rodrigo A. Cunha, 2019. Journal of Neurochemistry. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry
Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder
Cunha, Rodrigo, 2019. European Journal of Neuroscience. 2019. http://dx.doi.org/10.1111/ejn.14348 . 10.1111/ejn.14348 . European Journal of Neuroscience
The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors
João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, 2019. Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology
G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum
Cunha, Rodrigo, 2019. Neural Regeneration Research. 2019. http://dx.doi.org/10.4103/1673-5374.259610 . 10.4103/1673-5374.259610 . Neural Regeneration Research
Purinergic signalling and brain development
Cunha, Rodrigo, 2019. Seminars in Cell & Developmental Biology. 2019. http://dx.doi.org/10.1016/j.semcdb.2018.12.001 . 10.1016/j.semcdb.2018.12.001 . Seminars in Cell & Developmental Biology
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Cunha, Rodrigo, 2018. eneuro. 2018. http://dx.doi.org/10.1523/eneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Cunha, Rodrigo, 2018. Frontiers in Molecular Neuroscience. 2018. http://dx.doi.org/10.3389/fnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience
The exercise sex gap and the impact of the estrous cycle on exercise performance in mice
Aderbal S. Aguiar, Jr; Ana Elisa Speck; Inês M. Amaral; Paula M. Canas; Rodrigo A. Cunha, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-29050-0 . 10.1038/s41598-018-29050-0 . Scientific Reports
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience
Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
António C. Silva; Cristina Lemos; Francisco Q. Gonçalves; Anna V. Pliássova; Nuno J. Machado; Henrique B. Silva; Paula M. Canas; et al, 2018. Neurobiology of Disease. 72 - 81. 117. 2018. https://doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation
Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al, 2018. Cell Death and Disease. 3. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS . 10.1038/s41419-018-0351-1 . published Cell Death and Disease
Purinergic signalling and brain development.
Rodrigues, Ricardo J.; Joana M Marques; Cunha RA, 2018. Seminars in cell & developmental biology. 34 - 41. 95. 2018. http://europepmc.org/abstract/med/30529149 . 10.1016/j.semcdb.2018.12.001 . published Seminars in cell & developmental biology
Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice
Cunha, Rodrigo, 2018. Journal of Caffeine and Adenosine Research. 2018. http://dx.doi.org/10.1089/caff.2018.0016 . 10.1089/caff.2018.0016 . Journal of Caffeine and Adenosine Research
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro
Chronic coffee consumption and respiratory disease: A systematic review
Cunha, Rodrigo, 2018. The Clinical Respiratory Journal. 2018. http://dx.doi.org/10.1111/crj.12662 . 10.1111/crj.12662 . The Clinical Respiratory Journal
Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats
Cunha, Rodrigo, 2018. Frontiers in Neuroscience. 2018. http://dx.doi.org/10.3389/fnins.2018.00653 . 10.3389/fnins.2018.00653 . Frontiers in Neuroscience
Distinct sensitivity to caffeine-induced insomnia related to age
Cunha, Rodrigo, 2018. Journal of Psychopharmacology. 2018. http://dx.doi.org/10.1177/0269881117722997 . 10.1177/0269881117722997 . Journal of Psychopharmacology
Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation
Cunha, Rodrigo, 2018. Human Molecular Genetics. 2018. http://dx.doi.org/10.1093/hmg/ddy264 . 10.1093/hmg/ddy264 . Human Molecular Genetics
Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex
Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00133 . 10.3389/fphar.2018.00133 . Frontiers in Pharmacology
Elevated Pressure Changes the Purinergic System of Microglial Cells
Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2018.00016 . 10.3389/fphar.2018.00016 . Frontiers in Pharmacology
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation
Cunha, Rodrigo, 2018. Cell Death & Disease. 2018. http://dx.doi.org/10.1038/s41419-018-0351-1 . 10.1038/s41419-018-0351-1 . Cell Death & Disease
Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex
Cunha, Rodrigo, 2018. Frontiers in Pharmacology. 2018. http://dx.doi.org/10.3389/fphar.2017.00899 . 10.3389/fphar.2017.00899 . Frontiers in Pharmacology
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
Cunha, Rodrigo, 2018. Molecular Psychiatry. 2018. http://dx.doi.org/10.1038/s41380-018-0110-9 . 10.1038/s41380-018-0110-9 . Molecular Psychiatry
Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats
Cunha, Rodrigo, 2018. Behavioural Brain Research. 2018. http://dx.doi.org/10.1016/j.bbr.2018.05.007 . 10.1016/j.bbr.2018.05.007 . Behavioural Brain Research
Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex
Cunha, Rodrigo, 2018. European Journal of Neuroscience. 2018. http://dx.doi.org/10.1111/ejn.13912 . 10.1111/ejn.13912 . European Journal of Neuroscience
Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.
Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al, 2017. 2017. http://europepmc.org/abstract/med/26534909 . 10.1093/cercor/bhv268 .
Brain Membrane Fractionation: An <em>Ex Vivo </em>Approach to Assess Subsynaptic Protein Localization
Cunha, Rodrigo, 2017. Journal of Visualized Experiments. 2017. http://dx.doi.org/10.3791/55661 . 10.3791/55661 . Journal of Visualized Experiments
Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages
Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro, 2017. Pulmonary Pharmacology & Therapeutics. 90 - 94. 45. 2017. https://doi.org/10.1016/j.pupt.2017.04.009 . 10.1016/j.pupt.2017.04.009 . Pulmonary Pharmacology & Therapeutics
Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.
Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F, 2017. 2017. http://europepmc.org/abstract/med/28007645 . 10.1016/j.neulet.2016.12.040 .
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2017. 2017. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .
Boosting brain glucose metabolism to fight neurodegeneration?
de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential
Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al, 2017. Journal of Controlled Release. 58 - 71. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025167046&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.007 . published Journal of Controlled Release
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Gonçalves N; Simões AT; Prediger RD; Hirai H; Cunha RA; Pereira de Almeida L, 2017. 2017. http://europepmc.org/abstract/med/28032667 . 10.1002/ana.24867 .
Conference Paper: Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression.
Leal, Ermelindo C; Pirzgalska R; Dorinda Marques-da-Silva; Moura, Liane; Espinoza D; Ledent, C.; Köfalvi, Attila; Carvalho, Eugenia, 2017. Diabetologia. 119 - 119. S1. 60. 2017. http://dx.doi.org/10.1007/s00125-017-4350-z . 10.1007/s00125-017-4350-z . Diabetologia
Cannabis: A Treasure Trove or Pandora's Box?
Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry
P2 receptors control the migration of medial ganglionic eminence-derived interneurons
Ferreira, S.; Joana M Marques; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, Ricardo J., 2017. Journal of Neurochemistry. 2017. https://publons.com/publon/33584030/ . Journal of Neurochemistry
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential
Cunha, Rodrigo, 2017. Journal of Controlled Release. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.07.007 . 10.1016/j.jconrel.2017.07.007 . Journal of Controlled Release
Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety
L Caetano; H Pinheiro; P Patrício; A Mateus-Pinheiro; N D Alves; B Coimbra; F I Baptista; et al, 2017. Molecular Psychiatry. 1035 - 1043. 7. 22. 2017. https://doi.org/10.1038/mp.2016.173 . 10.1038/mp.2016.173 . Molecular Psychiatry
Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.
Machado NJ; Simões AP; Silva HB; Ardais AP; Kaster MP; Garção P; Rodrigues DI; et al, 2017. 2017. http://europepmc.org/abstract/med/26860412 . 10.1007/s12035-016-9774-9 .
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
Cunha, Rodrigo, 2017. Cell Death & Disease. 2017. http://dx.doi.org/10.1038/cddis.2017.451 . 10.1038/cddis.2017.451 . Cell Death & Disease
Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease
Cunha, Rodrigo, 2017. Journal of Alzheimer's Disease. 2017. http://doi.org/10.3233/JAD-170356 . 10.3233/JAD-170356 . Journal of Alzheimer's Disease
The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo
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Adenosine A<inf>2b</inf> receptors control A<inf>1</inf> receptor-mediated inhibition of synaptic transmission in the mouse hippocampus
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Adenosine A<inf>2B</inf> receptor activation stimulates glucose uptake in the mouse forebrain
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A Single Neurotoxic Dose of Methamphetamine Induces a Long-Lasting Depressive-Like Behaviour in Mice.
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Adenosine receptor antagonists including caffeine alter fetal brain development in mice
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CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation
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Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International
Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences
Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International
Pre-synaptic glycine GlyT1 transporter - NMDA receptor interaction: Relevance to NMDA autoreceptor activation in the presence of Mg 2+ ions
Musante, V.; Summa, M.; Cunha, R.A.; Raiteri, M.; Pittaluga, A., 2011. Journal of Neurochemistry. 516 - 527. 3. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953877316&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07223.x . Journal of Neurochemistry
Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing
Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, Ricardo J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . published European Journal of Neuroscience
Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging
De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology
Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.
Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia, 2011. Diabetologia. 458 - 458. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain
Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry
Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction
Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A., 2011. Journal of Neurochemistry. 100 - 111. 1. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07178.x . Journal of Neurochemistry
Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry
Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing
Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, 2011. European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . European Journal of Neuroscience
Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology
Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration
Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A., 2011. Biochimica et Biophysica Acta - Biomembranes. 1380 - 1399. 5. 1808. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS . 10.1016/j.bbamem.2010.12.001 . Biochimica et Biophysica Acta - Biomembranes
Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
Pandolfo, P.; Silveirinha, V.; Santos-Rodrigues, A.D.; Venance, L.; Ledent, C.; Takahashi, R.N.; Cunha, R.A.; Köfalvi, A., 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952535110&partnerID=MN8TOARS . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology
Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina
Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research
Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease
Agostinho, P.; Cunha, R.A.; Oliveira, C., 2010. Current Pharmaceutical Design. 2766 - 2778. 25. 16. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957970155&partnerID=MN8TOARS . Current Pharmaceutical Design
Conferenc Paper: Presynaptic A2A adenosine and CB1 cannabinoid receptors inhibit the function of one another at corticostriatal terminals.
Ferreira, Samira G.; Köfalvi, Attila; Cunha, Rodrigo A., 2010. Purinergic Signalling. 44 - 44. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life
Cognato, G.P.; Agostinho, P.M.; Hockemeyer, J.; Müller, C.E.; Souza, D.O.; Cunha, R.A., 2010. Journal of Neurochemistry. 453 - 462. 2. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150168&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06465.x . Journal of Neurochemistry
Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals
Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F., 2010. Neuroscience. 1589 - 1600. 4. 169. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.06.021 . Neuroscience
Conferenc Paper: Complex regulation of CB1-mediated effects by activation and blockade of striatal adenosine A2A receptors.
Tebano MT; Martire, A.; Köfalvi, Attila; Chiodi, V.; Ferrante A; Domenici MR; Ferreira, Samira G.; Cunha, Rodrigo A.; Popoli, P., 2010. Purinergic Signalling. 19 - 19. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders
Mendonça, A.; Cunha, R.A., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956222935&partnerID=MN8TOARS . 10.3233/JAD-2010-01420 . Journal of Alzheimer's Disease
Conferenc Paper: Blockade of synaptic adenosine A2A receptor prevents convulsion-induced damage.
Augusto, Elisabete; Paula M. Canas; Lisiane O. Porciúncula; Tiago M. Alfaro; Andrade GM; Köfalvi, Attila; Agostinho PM; Cunha, Rodrigo A., 2010. Purinergic Signalling. 108 - 108. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks.
de Mendonça, A.; Cunha, R.A., 2010. Journal of Alzheimer's disease : JAD. 20 Suppl 1. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956212740&partnerID=MN8TOARS . Journal of Alzheimer's disease : JAD
Conferenc Paper: Chronic caffeine treatment during adolescence improves behavioral flexibility in an animal model of attention deficit hyperactivity disorder.
Pandolfo, P.; Machado NM; Köfalvi, Attila; Takahashi RN; Cunha, Rodrigo A., 2010. Purinergic Signalling. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline
Cunha, R.A.; Agostinho, P.M., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954537925&partnerID=MN8TOARS . 10.3233/JAD-2010-1408 . Journal of Alzheimer's Disease
Caffeine, adenosine receptors, and synaptic plasticity
Costenla, A.R.; Cunha, R.A.; De Mendonça, A., 2010. Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956219897&partnerID=MN8TOARS . 10.3233/JAD-2010-091384 . Journal of Alzheimer's Disease
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by ß-amyloid peptides via p38 mitogen-activated protein kinase pathway
Canas, P.M.; Porciúncula, L.O.; Cunha, G.M.A.; Silva, C.G.; Machado, N.J.; Oliveira, J.M.A.; Oliveira, C.R.; Cunha, R.A., 2009. Journal of Neuroscience. 14741 - 14751. 47. 29. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449208698&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3728-09.2009 . Journal of Neuroscience
ATP (P2X1-3) AND alpha 3 beta 2 NICOTINIC ACETYLCHOLINE RECEPTORS INTERACT PHYSICALLY AND FUNCTIONALLY IN HIPPOCAMPAL TERMINALS
Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco, 2009. Journal of Physiological Sciences. 2009. https://publons.com/publon/8181593/ . Journal of Physiological Sciences
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Conferenc Paper: When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis.
Köfalvi, Attila, 2009. Journal of Neurochemistry. 103 - 104. s1. 110. 2009. http://dx.doi.org/10.1111/j.1471-4159.2009.06064_27.x . 10.1111/j.1471-4159.2009.06064_27.x . Journal of Neurochemistry
GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
Gomes, C.A.R.V.; Simões, P.F.; Canas, P.M.; Quiroz, C.; Sebastião, A.M.; Ferré, S.; Cunha, R.A.; Ribeiro, J.A., 2009. Journal of Neurochemistry. 1208 - 1219. 5. 108. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449098460&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.05876.x . Journal of Neurochemistry
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, Ricardo J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . published Neurobiology of Aging
Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway
Quiroz, C.; Luján, R.; Uchigashima, M.; Simoes, A.P.; Lerner, T.N.; Borycz, J.; Kachroo, A.; et al, 2009. TheScientificWorldJournal. 1321 - 1344. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949159248&partnerID=MN8TOARS . 10.1100/tsw.2009.143 . TheScientificWorldJournal
Spermine improves recognition memory deficit in a rodent model of Huntington's disease
Velloso, N.A.; Dalmolin, G.D.; Gomes, G.M.; Rubin, M.A.; Canas, P.M.; Cunha, R.A.; Mello, C.F., 2009. Neurobiology of Learning and Memory. 574 - 580. 4. 92. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949090346&partnerID=MN8TOARS . 10.1016/j.nlm.2009.07.006 . Neurobiology of Learning and Memory
Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Carvalho, R.A.; Cunha, R.A.; Gruetter, R., 2009. Journal of Neurochemistry. 368 - 379. 2. 111. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349338971&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06349.x . Journal of Neurochemistry
Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum
Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience
Conferenc Paper: Dual regulatory role of pre- and post-synaptic adenosine A2A receptors on CB1-mediated effects in the striatum.
Tebano MT; Martire A; Köfalvi, Attila; Chiodi, V.; Domenici MR; Pepponi R; Ferrante A; et al, 2009. Purinergic Signalling. 51 - 51. 1. 6. 2009. http://dx.doi.org/10.1007/s11302-009-9171-1 . 10.1007/s11302-009-9171-1 . Purinergic Signalling
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Caffeine, adenosine receptors, memory and Alzheimer's disease | Cafeína, receptores de adenosina, memoria y enfermedad de Alzheimer
Cunha, R.A., 2008. Medicina Clinica. 790 - 795. 20. 131. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-63549108150&partnerID=MN8TOARS . 10.1016/S0025-7753(08)75506-4 . Medicina Clinica
GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx
Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . Cell Calcium
Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells
Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . published Pancreas
GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx
Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., 2008. Cell Calcium. 521 - 532. 6. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS . 10.1016/j.ceca.2008.03.006 . published Cell Calcium
Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats
Rodrigues, Ricardo J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . accepted Neurobiology of Aging
Potential therapeutic interest of adenosine A2A receptors in Psychiatric disorders
Cunha, R.A.; Ferré, S.; Vaugeois, J.-M.; Chen, J.-F., 2008. Current Pharmaceutical Design. 1512 - 1524. 15. 14. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349125085&partnerID=MN8TOARS . 10.2174/138161208784480090 . Current Pharmaceutical Design
Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats
Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., 2008. Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2007.03.025 . Neurobiology of Aging
Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses
Rebola, N.; Lujan, R.; Cunha, R.A.; Mulle, C., 2008. Neuron. 121 - 134. 1. 57. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549021899&partnerID=MN8TOARS . 10.1016/j.neuron.2007.11.023 . Neuron
Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity
Cunha, R.A., 2008. Neurochemistry International. 65 - 72. 1. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849073199&partnerID=MN8TOARS . 10.1016/j.neuint.2007.06.026 . Neurochemistry International
Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells
Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., 2008. Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . Pancreas
Adenosine A2A receptor blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801
Cunha, G.M.A.; Canas, P.M.; Melo, C.S.; Hockemeyer, J.; Müller, C.E.; Oliveira, C.R.; Cunha, R.A., 2008. Experimental Neurology. 776 - 781. 2. 210. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136710&partnerID=MN8TOARS . 10.1016/j.expneurol.2007.11.013 . Experimental Neurology
An update on adenosine A2A-dopamine D2 receptor interactions: Implications for the function of G protein-coupled receptors
Ferré, S.; Quiroz, C.; Woods, A.S.; Cunha, R.; Popoli, P.; Ciruela, F.; Lluis, C.; et al, 2008. Current Pharmaceutical Design. 1468 - 1474. 15. 14. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47349126631&partnerID=MN8TOARS . 10.2174/138161208784480108 . Current Pharmaceutical Design
A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs
Shen, H.-Y.; Coelho, J.E.; Ohtsuka, N.; Canas, P.M.; Day, Y.-J.; Huang, Q.-Y.; Rebola, N.; et al, 2008. Journal of Neuroscience. 2970 - 2975. 12. 28. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149136068&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5255-07.2008 . Journal of Neuroscience
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms
Yu, L.; Shen, H.-Y.; Coelho, J.E.; Araújo, I.M.; Huang, Q.-Y.; Day, Y.-J.; Rebola, N.; et al, 2008. Annals of Neurology. 338 - 346. 3. 63. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849085227&partnerID=MN8TOARS . 10.1002/ana.21313 . Annals of Neurology
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, Ricardo J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . published Journal of Neurochemistry
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Oses, J.P.; Rodrigues, Ricardo J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . published Neuroscience
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Conferenc Paper: CB1 cannabinoid receptors in the physiopathology of hippocampal glucose homeostasis.
Duarte, JMN; Nogueira, C.; Carvalho; Mackie, K.; Oliveira, CR; Cunha, Rodrigo A.; Köfalvi, Attila, 2007. Journal of Neurochemistry. 115 - 115. s1. 102. 2007. http://dx.doi.org/10.1111/j.0022-3042.2007.04727.x . 10.1111/j.0022-3042.2007.04727.x . Journal of Neurochemistry
Adenosine A2A receptors and basal ganglia physiology
Schiffmann, S.N.; Fisone, G.; Moresco, R.; Cunha, R.A.; Ferré, S., 2007. Progress in Neurobiology. 277 - 292. 5. 83. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36148983766&partnerID=MN8TOARS . 10.1016/j.pneurobio.2007.05.001 . Progress in Neurobiology
Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A., 2007. Neuroscience. 382 - 391. 2. 149. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS . 10.1016/j.neuroscience.2007.08.005 . Neuroscience
Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons
Silva, C.G.; Porciúncula, L.O.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2007. Neurobiology of Disease. 182 - 189. 2. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447634291&partnerID=MN8TOARS . 10.1016/j.nbd.2007.04.018 . Neurobiology of Disease
Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy
Duarte, J.M.N.; Cunha, R.A.; Carvalho, R.A., 2007. Neuroscience. 1305 - 1313. 4. 144. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846274201&partnerID=MN8TOARS . 10.1016/j.neuroscience.2006.11.027 . Neuroscience
Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses
Rebola, N.; Sachidhanandam, S.; Perrais, D.; Cunha, R.A.; Mulle, C., 2007. Journal of Neuroscience. 3987 - 3993. 15. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247146060&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5182-06.2007 . Journal of Neuroscience
Caffeine and adenosine A2a receptor antagonists prevent ß-amyloid (25-35)-induced cognitive deficits in mice
Dall'Igna, O.P.; Fett, P.; Gomes, M.W.; Souza, D.O.; Cunha, R.A.; Lara, D.R., 2007. Experimental Neurology. 241 - 245. 1. 203. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751427701&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.08.008 . Experimental Neurology
Adenosine receptor heteromers and their integrative role in striatal function
Ferré, S.; Ciruela, F.; Quiroz, C.; Luján, R.; Popoli, P.; Cunha, R.A.; Agnati, L.F.; et al, 2007. TheScientificWorldJournal. 74 - 85. SUPPL. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249058539&partnerID=MN8TOARS . 10.1100/tsw.2007.211 . TheScientificWorldJournal
Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Oliveira, C.R.; Ambrósio, A.F.; Cunha, R.A., 2006. Neurochemistry International. 144 - 150. 2. 48. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450466&partnerID=MN8TOARS . 10.1016/j.neuint.2005.08.008 . Neurochemistry International
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters
Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress
Cunha, G.M.A.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience. 1775 - 1781. 4. 141. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747160404&partnerID=MN8TOARS . 10.1016/j.neuroscience.2006.05.024 . Neuroscience
Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus
Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . Journal of Molecular Neuroscience
Hypoxia-induced desensitization and internalization of adenosine A 1 receptors in the rat hippocampus
Coelho, J.E.; Rebola, N.; Fragata, I.; Ribeiro, J.A.; De Mendonça, A.; Cunha, R.A., 2006. Neuroscience. 1195 - 1203. 4. 138. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644838682&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.12.012 . Neuroscience
TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus
Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . Journal of Neuroscience Research
Regulation of neurotransmitter release by presynaptic P2X receptors
Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters
Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
Ciruela, F.; Casadó, V.; Rodrigues, Ricardo J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . published Journal of Neuroscience
Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus
Rodrigues, Ricardo J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., 2006. Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS . 10.1385/JMN:30:1:173 . published Journal of Molecular Neuroscience
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, Ricardo J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . published Molecular Pharmacology
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus
Pereira, D.B.; Rebola, N.; Rodrigues, Ricardo J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., 2006. Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS . 10.1002/jnr.20784 . published Journal of Neuroscience Research
Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin
Joana M Marques; Rodrigues, Ricardo J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T., 2006. Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS . 10.1074/jbc.M603753200 . published Journal of Biological Chemistry
Heterodimeric adenosine receptors: A device to regulate neurotransmitter release
Ciruela, F.; Ferré, S.; Casadó, V.; Cortés, A.; Cunha, R.A.; Lluis, C.; Franco, R., 2006. Cellular and Molecular Life Sciences. 2427 - 2431. 21. 63. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882222&partnerID=MN8TOARS . 10.1007/s00018-006-6216-2 . Cellular and Molecular Life Sciences
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, 2006. Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3574-05.2006 . Journal of Neuroscience
Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus
Rebola, N.; Rodrigues, Ricardo J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . published Neuroscience
Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
Rodrigues, Ricardo J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neurochemistry. 433 - 441. 3. 92. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244264871&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02887.x . published Journal of Neurochemistry
Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons
Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neurochemistry International. 317 - 325. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044454590&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.009 . published Neurochemistry International
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus
Rodrigues, Ricardo J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Journal of Neuroscience. 6286 - 6295. 27. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844443354&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0628-05.2005 . published Journal of Neuroscience
Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses
Pinheiro, P.S.; Rodrigues, Ricardo J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., 2005. Neurochemistry International. 309 - 316. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.007 . published Neurochemistry International
Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat
Rebola, N.; Canas, P.M.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 893 - 903. 4. 132. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344362097&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.014 . Neuroscience
Purinergic control of GABA release
Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA, 2005. Journal of Neurochemistry. 2005. https://publons.com/publon/27547643/ . Journal of Neurochemistry
Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia
Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . published Journal of Neuroscience
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.
Rebola N; Porciúncula LO; Lopes LV; Oliveira CR; Soares-da-Silva P; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/15987272 . 10.1111/j.1528-1167.2005.01026.x .
Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.
Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/18404497 . 10.1007/s11302-005-0649-1 .
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.
Köfalvi A; Rodrigues RJ; Ledent C; Mackie K; Vizi ES; Cunha RA; Sperlágh B, 2005. 2005. http://europepmc.org/abstract/med/15772347 . 10.1523/JNEUROSCI.4232-04.2005 .
Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.
Ferré S; Borycz J; Goldberg SR; Hope BT; Morales M; Lluis C; Franco R; Ciruela F; Cunha R, 2005. 2005. http://europepmc.org/abstract/med/16385640 . 10.1142/S0219635205000987 .
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
Rodrigues RJ; Almeida T; Richardson PJ; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/16000618 . 10.1523/JNEUROSCI.0628-05.2005 .
Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.
Pinto-Duarte A; Coelho JE; Cunha RA; Ribeiro JA; Sebastião AM, 2005. 2005. http://europepmc.org/abstract/med/15836618 . 10.1111/j.1471-4159.2005.03071.x .
Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum.
Rodrigues RJ; Alfaro TM; Rebola N; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/15659214 . 10.1111/j.1471-4159.2004.02887.x .
Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.
Rebola N; Rodrigues RJ; Oliveira CR; Cunha RA, 2005. 2005. http://europepmc.org/abstract/med/16011860 . 10.1016/j.neuint.2005.05.009 .
Long-term effect of convulsive behavior on the density of adenosine A 1 and A 2A receptors in the rat cerebral cortex
Rebola, N.; Porciúncula, L.O.; Lopes, L.V.; Oliveira, C.R.; Soares-Da-Silva, P.; Cunha, R.A., 2005. Epilepsia. 159 - 165. SUPPL. 5. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844450198&partnerID=MN8TOARS . Epilepsia
Adenosine and brain function.
Fredholm BB; Chen JF; Cunha RA; Svenningsson P; Vaugeois JM, 2005. 2005. http://europepmc.org/abstract/med/15797469 . 10.1016/S0074-7742(05)63007-3 .
Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus
Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2005. Neuroscience. 79 - 83. 1. 133. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS . 10.1016/j.neuroscience.2005.01.054 . Neuroscience
Effect of free radicals on adenosine A2A and dopamine D 2 receptors in the striatum of young adult and aged rats
Alfaro, T.M.; Vigia, E.; Oliveira, C.R.; Cunha, R.A., 2004. Neurochemistry International. 733 - 738. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042601106&partnerID=MN8TOARS . 10.1016/j.neuint.2004.02.003 . Neurochemistry International
Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid
Cunha, R.A.; Ribeiro, J.A.; Malva, J.O., 2004. Neurochemistry International. 371 - 379. 5. 44. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345304227&partnerID=MN8TOARS . 10.1016/S0197-0186(03)00167-0 . Neurochemistry International
Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: Evidence that CGS 21680 binds to A1 receptors in hippocampus
Halldner, L.; Lopes, L.V.; Daré, E.; Lindström, K.; Johansson, B.; Ledent, C.; Cunha, R.A.; Fredholm, B.B., 2004. Naunyn-Schmiedeberg's Archives of Pharmacology. 270 - 278. 4. 370. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244262300&partnerID=MN8TOARS . 10.1007/s00210-004-0970-1 . Naunyn-Schmiedeberg's Archives of Pharmacology
Release and neuromodulatory role of ATP in hippocampal synapses
Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181529/ . Fundamental & Clinical Pharmacology
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices
Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics
Conferenc Paper: Ischemia induced up-regulation of P2X7 receptors on GABAergic neurons in corticoencephalic cell cultures.
Günther, A.; Köfalvi, Attila; Reinhardt, R.; Franke, F.; Madarász, E.; Vizi, E. Sylvester; Schneider, D.; et al, 2004. European Journal of Neurology. 58 - 58. s2. 11. 2004. http://dx.doi.org/10.1111/j.1468-1331.2004.00919.x . 10.1111/j.1468-1331.2004.00919.x . European Journal of Neurology
Binding of the prototypical adenosine A 2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A 1 and A 2A receptor knockout mice
Lopes, L.V.; Halldner, L.; Rebola, N.; Johansson, B.; Ledent, C.; Chen, J.F.; Fredholm, B.B.; Cunha, R.A., 2004. British Journal of Pharmacology. 1006 - 1014. 6. 141. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942472484&partnerID=MN8TOARS . 10.1038/sj.bjp.0705692 . British Journal of Pharmacology
Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum
Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B., 2004. Fundamental & Clinical Pharmacology. 2004. https://publons.com/publon/8181569/ . Fundamental & Clinical Pharmacology
Conferenc Paper: Regulation of transmitter release in the CNS by cannabinoid receptors.
Sperlágh, B.; Köfalvi, Attila; E. Sylvester Vizi, 2004. Pharmacology. 141 - 141. 2. 72. 2004. http://dx.doi.org/10.1159/000080185 . 10.1159/000080185 . Pharmacology
Conferenc Paper: The role of presynaptic P2X receptors in the regulation of tritiated NA release from rat hippocampal slices.
Papp, L.; Balázsa, T.; Köfalvi, Attila; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 37 - 37. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
Conferenc Paper: Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the rodent striatum.
Köfalvi, Attila; Ricardo J. Rodrigues; Cunha, Rodrigo A.; Catherine Ledent; Vizi, E. Sylvester; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 57 - 57. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices
Almeida, T.; Rodrigues, Ricardo J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . published Neuroscience
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action
Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience
Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors
Malva, J.O.; Silva, A.P.; Cunha, R.A., 2003. Neurochemical Research. 1501 - 1515. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS . 10.1023/A:1025618324593 . Neurochemical Research
Heteroexchange of purines in the hippocampus: Mixing-up or messing-up ATP and adenosine
Cunha, R.A., 2003. British Journal of Pharmacology. 473 - 474. 3. 139. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038002126&partnerID=MN8TOARS . British Journal of Pharmacology
Adenosine A3 receptors are located in neurons of the rat hippocampus
Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., 2003. NeuroReport. 1645 - 1648. 12. 14. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS . 10.1097/00001756-200308260-00021 . NeuroReport
Pharmacology of adenosine A2A receptors and therapeutic applications.
Fredholm, B.B.; Cunha, R.A.; Svenningsson, P., 2003. Current topics in medicinal chemistry. 413 - 426. 4. 3. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038143146&partnerID=MN8TOARS . Current topics in medicinal chemistry
Neuroprotection by caffeine and adenosine A 2A receptor blockade of ß-amyloid neurotoxicity
Dall'lgna, O.P.; Porciúncula, L.O.; Souza, D.O.; Cunha, R.A.; Lara, D.R., 2003. British Journal of Pharmacology. 1207 - 1209. 7. 138. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038415954&partnerID=MN8TOARS . 10.1038/sj.bjp.0705185 . British Journal of Pharmacology
ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve
Santos, D.A.; Salgado, A.I.; Cunha, R.A., 2003. Neuroscience Letters. 225 - 228. 3. 338. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422297&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01419-2 . Neuroscience Letters
Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices
Almeida, C.G.; De Mendonça, A.; Cunha, R.A.; Ribeiro, J.A., 2003. Neuroscience Letters. 127 - 130. 2. 339. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457352&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01478-7 . Neuroscience Letters
Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus
Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . Neuroscience Letters
Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors
Lopes, L.V.; Rebola, N.; Costenla, A.R.; Halldner, L.; Jacobson, M.A.; Oliveira, C.R.; Richardson, P.J.; et al, 2003. Drug Development Research. 428 - 438. 4. 58. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038388748&partnerID=MN8TOARS . 10.1002/ddr.10188 . Drug Development Research
Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings
Magalhães-Cardoso, M.T.; Pereira, M.F.; Oliveira, L.; Ribeiro, J.A.; Cunha, R.A.; Correia-de-Sá, P., 2003. Journal of Physiology. 399 - 408. 2. 549. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038511040&partnerID=MN8TOARS . Journal of Physiology
Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats
Rebola, N.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; Oliveira, C.R.; Soares-da-Silva, P.; De Mendonça, A.; Cunha, R.A., 2003. European Journal of Neuroscience. 820 - 828. 4. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042819806&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02815.x . European Journal of Neuroscience
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices
Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., 2003. Neuroscience. 111 - 121. 1. 122. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS . 10.1016/S0306-4522(03)00523-2 . Neuroscience
Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus
Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., 2003. Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . published Neuroscience Letters
Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus
Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A., 2003. Brain Research. 49 - 58. 1. 987. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS . 10.1016/S0006-8993(03)03247-5 . Brain Research
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats
Rebola, N.; Sebastião, A.M.; De Mendonca, A.; Oliveira, C.R.; Ribeiro, J.A.; Cunha, R.A., 2003. Journal of Neurophysiology. 1295 - 1303. 2. 90. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042817860&partnerID=MN8TOARS . 10.1152/jn.00896.2002 . Journal of Neurophysiology
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry
Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition
Lopes, L.V.; Cunha, R.A.; Kull, B.; Fredholm, B.B.; Ribeiro, J.A., 2002. Neuroscience. 319 - 329. 2. 112. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037129938&partnerID=MN8TOARS . 10.1016/S0306-4522(02)00080-5 . Neuroscience
Adenosine A 2A receptors in portal hypertension: Their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits
Villa de Brito, M.T.; Canto, A.; Duarte Correia, J.H.; Cunha, R.A.; Marques, M.C., 2002. British Journal of Pharmacology. 1324 - 1330. 5. 135. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036196797&partnerID=MN8TOARS . British Journal of Pharmacology
Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation
Díaz-Hernández, M.; Fátima Pereira, M.; Pintor, J.; Cunha, R.A.; Ribeiro, J.A.; Miras-Portugal, M.T., 2002. Journal of Pharmacology and Experimental Therapeutics. 441 - 450. 2. 301. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232217&partnerID=MN8TOARS . 10.1124/jpet.301.2.441 . Journal of Pharmacology and Experimental Therapeutics
Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices
Cunha, R.A.; Coelho, J.E.; Costenla, A.R.; Lopes, L.V.; Parada, A.; De Mendonça, A.; Sebastião, A.M.; Ribeiro, J.A., 2002. Pharmacology and Toxicology. 208 - 213. 4. 90. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251881&partnerID=MN8TOARS . 10.1034/j.1600-0773.2002.900407.x . Pharmacology and Toxicology
Transducing system operated by adenosine A2A receptors to facilitate acetylcholine release in the rat hippocampus
Rebola, N.; Oliveira, C.R.; Cunha, R.A., 2002. European Journal of Pharmacology. 31 - 38. 1. 454. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036843638&partnerID=MN8TOARS . 10.1016/S0014-2999(02)02475-5 . European Journal of Pharmacology
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors
Cunha, R.A., 2001. Neurochemistry International. 107 - 125. 2. 38. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255227&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00034-6 . Neurochemistry International
Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord
Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International
Age-dependent decrease in adenosine A 1 receptor binding sites in the rat brain: Effect of cis unsaturated free fatty acids
Cunha, R.A.; Dolores Constantino, M.; Fonseca, E.; Ribeiro, J.A., 2001. European Journal of Biochemistry. 2939 - 2947. 10. 268. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034830959&partnerID=MN8TOARS . 10.1046/j.1432-1327.2001.02183.x . European Journal of Biochemistry
Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals
Cunha, R.A., 2001. Neurochemical Research. 979 - 991. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034753234&partnerID=MN8TOARS . 10.1023/A:1012392719601 . Neurochemical Research
Conferenc Paper: ATP releases [3H]GABA from rat hippocampal slices via P2X7 receptor activation.
Köfalvi, Attila; Baranyi M; Vizi ES; Sperlagh, B., 2001. Fundamental and Clinical Pharmacology. 135 - 135. S1. 15. 2001. http://dx.doi.org/10.1046/j.1472-8206.2001.00113.x . 10.1046/j.1472-8206.2001.00113.x . Fundamental and Clinical Pharmacology
Bringing the brain into the test tube: An experiment illustrating the effect of ethanol on nerve terminal viability
Cunha, R.A., 2001. Biochemistry and Molecular Biology Education. 105 - 109. 3. 29. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899059&partnerID=MN8TOARS . 10.1016/S1470-8175(01)00035-2 . Biochemistry and Molecular Biology Education
Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: Comparison with carbamazepine
Bonifácio, M.J.; Sheridan, R.D.; Parada, A.; Cunha, R.A.; Patmore, L.; Soares-Da-Silva, P., 2001. Epilepsia. 600 - 608. 5. 42. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035013202&partnerID=MN8TOARS . 10.1046/j.1528-1157.2001.43600.x . Epilepsia
Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats
Cunha, R.A.; Almeida, T.; Ribeiro, J.A., 2001. Journal of Neurochemistry. 372 - 382. 2. 76. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035140223&partnerID=MN8TOARS . 10.1046/j.1471-4159.2001.00095.x . Journal of Neurochemistry
Adenosine receptor interactions in the hippocampus
Ribeiro, J.A.; Cunha-Reis, D.; Lopes, L.V.; Coelho, J.E.; Costenla, A.R.; Correia-de-Sá, P.; Cunha, R.A.; De Mendonça, A.; Sebastiao, A.M., 2001. Drug Development Research. 337 - 345. 1-2. 52. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035028567&partnerID=MN8TOARS . 10.1002/ddr.1132 . Drug Development Research
Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens
Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research
Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation
Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics
Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals
Pereira, M.F.; Hernández, M.D.; Pintor, J.; Miras-Portugal, M.T.; Cunha, R.A.; Ribeiro, J.A., 2000. Brain Research. 50 - 54. 1-2. 879. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342472159&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02726-8 . Brain Research
Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress
Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R., 2000. Neurochemistry International. 255 - 265. 3. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00113-8 . Neurochemistry International
Cellular Neurophysiology
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; E. Sylvester Vizi; Sperlagh, B., 2000. Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus. . suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience
Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells
Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R., 2000. Experimental Eye Research. 577 - 587. 5. 70. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS . 10.1006/exer.1999.0815 . Experimental Eye Research
Conference Paper: Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; Vizi ES; Sperlágh, B., 2000. The Journal of Physiology. 64 - 65. suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . The Journal of Physiology
Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus
Cunha, R.A.; Brendel, P.; Zimmermann, H.; Ribeiro, J.A., 2000. Journal of Neurochemistry. 334 - 338. 1. 74. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033970847&partnerID=MN8TOARS . 10.1046/j.1471-4159.2000.0740334.x . Journal of Neurochemistry
ATP as a presynaptic modulator
Cunha, R.A.; Ribeiro, J.A., 2000. Life Sciences. 119 - 137. 2. 68. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034554789&partnerID=MN8TOARS . Life Sciences
Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats
Sebastião, A.M.; Cunha, R.A.; De Mendonça, A.; Ribeiro, J.A., 2000. British Journal of Pharmacology. 1629 - 1634. 8. 131. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034531574&partnerID=MN8TOARS . British Journal of Pharmacology
Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus
Cunha, R.A.; Almeida, T.; Ribeiro, J.A., 2000. Journal of Biological Chemistry. 37572 - 37581. 48. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535956&partnerID=MN8TOARS . 10.1074/jbc.M003011200 . Journal of Biological Chemistry
Meeting Report - Biochemical Education at the University Level, Lisbon, Portugal, October 30-31, 1999
Cunha, R.A.; Cyrne, L.; Castanho, M.; Freire, A.P., 2000. Biochemistry and Molecular Biology Education. 234 - 237. 4. 28. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033744526&partnerID=MN8TOARS . 10.1016/S1470-8175(00)00008-4 . Biochemistry and Molecular Biology Education
Facilitation by P2 receptor activation of acetylcholine release from rat motor nerve terminals: Interaction with presynaptic nicotinic receptors
Salgado, A.I.; Cunha, R.A.; Ribeiro, J.A., 2000. Brain Research. 245 - 250. 2. 877. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703241&partnerID=MN8TOARS . 10.1016/S0006-8993(00)02679-2 . Brain Research
Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats
Pereira, M.F.; Cunha, R.A.; Ribeiro, J.A., 2000. Neurochemistry International. 563 - 566. 7. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034214262&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00164-3 . Neurochemistry International
Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation
Cunha, R.A.; Ribeiro, J.A., 2000. Neuroscience Letters. 127 - 130. 2. 289. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033624133&partnerID=MN8TOARS . 10.1016/S0304-3940(00)01295-7 . Neuroscience Letters
Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release
A. Cunha, R.; Malva, J.O.; Ribeiro, J.A., 2000. FEBS Letters. 159 - 162. 2-3. 469. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034629239&partnerID=MN8TOARS . 10.1016/S0014-5793(00)01272-2 . FEBS Letters
Purinergic modulation of [3H]GABA release from rat hippocampal nerve terminals
Cunha, R.A.; Ribeiro, J.A., 2000. Neuropharmacology. 1156 - 1167. 7. 39. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034064253&partnerID=MN8TOARS . 10.1016/S0028-3908(99)00237-3 . Neuropharmacology
Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases
Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A., 1999. Progress in Brain Research. 183 - 192. 120. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS . Progress in Brain Research
Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes
Cunha, R.A.; Ribeiro, J.A., 1999. European Journal of Neuroscience. 2171 - 2174. 6. 11. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033047188&partnerID=MN8TOARS . 10.1046/j.1460-9568.1999.00661.x . European Journal of Neuroscience
Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus
Cunha, R.A.; Malva, J.O.; Ribeiro, J.A., 1999. Molecular Pharmacology. 429 - 433. 2. 56. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032793961&partnerID=MN8TOARS . Molecular Pharmacology
G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors
Cunha, R.A.; Constantino, M.D.; Ribeiro, J.A., 1999. Naunyn-Schmiedeberg's Archives of Pharmacology. 295 - 302. 4. 359. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947295&partnerID=MN8TOARS . 10.1007/PL00005355 . Naunyn-Schmiedeberg's Archives of Pharmacology
Anticonvulsant and sodium channel-blocking properties of novel 10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives
Benes, J.; Parada, A.; Figueiredo, A.A.; Alves, P.C.; Freitas, A.P.; Learmonth, D.A.; Cunha, R.A.; Garrett, J.; Soares-Da-Silva, P., 1999. Journal of Medicinal Chemistry. 2582 - 2587. 14. 42. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566070&partnerID=MN8TOARS . 10.1021/jm980627g . Journal of Medicinal Chemistry
Conference Paper: The Effect of Nicotine on GABA Release from Rat Hippocampal Slices is Mediated via alpha7-Type Homopentameric Neuronal Nicotinic Acetylcholine Receptors
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Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
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Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A(2A) receptors in the limbic cortex, but not striatum, of aged rats
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ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A1 receptor responses
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Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus
Almeida, T.; Cunha, R.A.; Ribeiro, J.A., 1999. Brain Research. 104 - 111. 1. 826. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033599818&partnerID=MN8TOARS . 10.1016/S0006-8993(99)01267-6 . Brain Research
Cross talk between A1 and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats
Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A., 1999. Journal of Neurophysiology. 3196 - 3203. 6. 82. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033390941&partnerID=MN8TOARS . Journal of Neurophysiology
Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors
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On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology (multiple letters)
Cunha, R.A.; Foster, T.C.; Norris, C.M.; Verkhratsky, A.; Toescu, E.C., 1998. Trends in Neurosciences. 286 - 287. 7. 21. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031798434&partnerID=MN8TOARS . Trends in Neurosciences
ZM241385 is an antagonist of the facilitatory responses produced by the A(2A) adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus
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Inhibition of [3H]¿-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes
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Adenosine A(2A) receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes
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Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides
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Purinergic regulation of acetylcholine release
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Purinoceptors and synaptic plasticity
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Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors
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A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion
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Relative contribution of nerve endings to the release of adenine nucleotides in the innervated frog sartorius muscle
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Blockade of AMP degradation allows the quantification of adenine nucleotides released by nerve stimulation in the innervated frog sartorius muscle
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Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography
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P2Y1 Receptor-CRMP2 control synaptic loss and memory impairment in early Alzheimer’s disease
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5 6 de 6 Projectos Passados de I&D
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