Glucose
Endocannabinoid
Adenosine
Neuron
Glia
Changes in Neuromodulation of Corticostriatal Terminals in a Rat Model of Willis-Ekbom Disease
Investigating the role of Adenosine A2ARs in Brain Glucoregulation
The Novel Endocannabinoid Receptor, GPR55 Stimulates Glycolysis in Astrocytes
Fed-State-Dependent Modulation of Hippocampal Synaptic Plasticity by Insulin
Brain glucose metabolism is tightly coupled to neural activity. My lab investigates how modulators of neural activity regulate cerebral energy metabolism. The neuromodulators we are currently interested in and show promising therapeutic potential are adenosine, endocannabinoids and insulin-like peptides. Why is this research important? All neurological and psychiatric disorders are linked with persistent changes in glucose metabolism in very specific regions in the human brain. 18F-deoxyglucose and functional MRI imaging help neurologists detect these alterations. These metabolic dysregulations often precede the loss of brain cells by years. Hence, understanding the selective early markers of brain disorders can help the physicians to categorize the illness and select the appropriate treatments as early as possible. Many times, early recognition of the disease and swift decision on the treatment make the difference. Hence, we also would like to know if the restoration of the impaired brain glucoregulation could improve the outcome of the given brain disease, or even, prevent the onset of it. We are studying basic signalling systems, both in vitro and in vivo in animal models with the future aim of re-testing the promising ideas in humans. We mostly use neurochemistry, flow citometry, microscopy, electrophysiology in brain slices and cell cultures and in vivo behaviour in rodent disease models.
Information about journal articles, updated at 22-12-2024, from platform CIÊNCIAVITAE.
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Ricardo J. Rodrigues; Joana M. Marques; Attila Köfalvi, 2024. Cells. 2024. https://doi.org/10.3390/cells13221875 . 10.3390/cells13221875 . Cells
Targeting corticostriatal transmission for the treatment of cannabinoid use disorder
Sergi Ferre; Attila Köfalvi; Francisco Ciruela; Zuzana Justinova; Marco Pistis, 2023. Trends in Pharmacological Sciences. 495 - 506. 8. 44. 2023. http://dx.doi.org/10.1016/j.tips.2023.05.003 . 10.1016/j.tips.2023.05.003 . Trends in Pharmacological Sciences
Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome
Matilde S. Rodrigues; Samira G. Ferreira; César Quiroz; Christopher J. Earley; Diego García-Borreguero; Rodrigo A. Cunha; Francisco Ciruela; Attila Köfalvi; Sergi Ferré, 2022. Molecules. 2022. https://doi.org/10.3390/molecules27051489 . 10.3390/molecules27051489 . Molecules
Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.
Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia, 2021. Experimental gerontology. 154. 2021. https://doi.org/10.1016/j.exger.2021.111528 . 10.1016/j.exger.2021.111528 . published Experimental gerontology
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, 2020. Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, 2020. European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, Ramón; et al, 2020. BMC Biology. 1. 18. 2020. http://dx.doi.org/10.1186/s12915-020-0739-0 . 10.1186/s12915-020-0739-0 . BMC Biology
The Yin and Yang of Adenosine Receptors: A Piquant Story
Köfalvi, Attila, 2020. Journal of Caffeine and Adenosine Research. 2020. http://dx.doi.org/10.1089/caff.2020.0004 . 10.1089/caff.2020.0004 . Journal of Caffeine and Adenosine Research
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Moura, Liane I.F.; Lemos, Cristina; Ledent, Catherine; Carvalho, Eugénia; Köfalvi, Attila, 2019. Brain Research Bulletin. 101 - 109. 147. 2019. http://dx.doi.org/10.1016/j.brainresbull.2019.01.024 . 10.1016/j.brainresbull.2019.01.024 . Brain Research Bulletin
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism
Mouro, Francisco M.; Köfalvi, Attila; André, Luís A.; Baqi, Younis; Müller, Christa E.; Ribeiro, Joaquim A.; Sebastião, Ana M., 2019. Neuropharmacology. 10 - 21. 155. 2019. http://dx.doi.org/10.1016/j.neuropharm.2019.05.003 . 10.1016/j.neuropharm.2019.05.003 . Neuropharmacology
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.
Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al, 2018. Cell death & disease. 2018. http://europepmc.org/abstract/med/29463792 . 10.1038/s41419-018-0351-1 . Cell death & disease
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making
Douglas T. Leffa; Pablo Pandolfo; Nélio Gonçalves; Nuno J. Machado; Carolina M. de Souza; Joana I. Real; António C. Silva; et al, 2018. Frontiers in Molecular Neuroscience. 11. 2018. https://doi.org/10.3389%2Ffnmol.2018.00475 . 10.3389/fnmol.2018.00475 . Frontiers in Molecular Neuroscience
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al, 2018. eneuro. ENEURO.0385 - 18.2018. 6. 5. 2018. https://doi.org/10.1523%2Feneuro.0385-18.2018 . 10.1523/eneuro.0385-18.2018 . eneuro
Boosting brain glucose metabolism to fight neurodegeneration?
de Ceballos ML; Köfalvi A, 2017. 2017. http://europepmc.org/abstract/med/28184023 . 10.18632/oncotarget.15131 .
Cannabis: A Treasure Trove or Pandora's Box?
Katalin Solymosi; Köfalvi, Attila, 2017. Mini-Reviews in Medicinal Chemistry. 13. 17. 2017. https://doi.org/10.2174%2F1389557516666161004162133 . 10.2174/1389557516666161004162133 . Mini-Reviews in Medicinal Chemistry
Conference Paper: Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression.
Leal, Ermelindo C; Pirzgalska R; Dorinda Marques-da-Silva; Moura, Liane; Espinoza D; Ledent, C.; Köfalvi, Attila; Carvalho, Eugenia, 2017. Diabetologia. 119 - 119. S1. 60. 2017. http://dx.doi.org/10.1007/s00125-017-4350-z . 10.1007/s00125-017-4350-z . Diabetologia
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
Bárbara S. Pinheiro; Cristina Lemos; Fernanda Neutzling Kaufmann; Joana M. Marques; Carla S. da Silva-Santos; Eugénia Carvalho; Ken Mackie; et al, 2016. Brain Research Bulletin. 222 - 230. 124. 2016. https://doi.org/10.1016/j.brainresbull.2016.05.009 . 10.1016/j.brainresbull.2016.05.009 . Brain Research Bulletin
Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses
Nuno J. Machado; Ana Patrícia Simões; Henrique B. Silva; Ana Paula Ardais; Manuella P. Kaster; Pedro Garção; Diana I. Rodrigues; et al, 2016. Molecular Neurobiology. 1552 - 1563. 2. 54. 2016. https://doi.org/10.1007%2Fs12035-016-9774-9 . 10.1007/s12035-016-9774-9 . Molecular Neurobiology
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Fonseca R; Carvalho RA; Lemos C; Sequeira AC; Pita IR; Carvalho F; Silva CD; et al, 2016. 2016. http://europepmc.org/abstract/med/27762079 . 10.1111/cns.12649 .
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease
Attila Köfalvi; Cristina Lemos; Ana M. Martín-Moreno; Bárbara S. Pinheiro; Luis García-García; Miguel A. Pozo; Ângela Valério-Fernandes; et al, 2016. Neuropharmacology. 519 - 529. 110. 2016. https://doi.org/10.1016/j.neuropharm.2016.03.015 . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology
Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices
Paula Valente-Silva; Cristina Lemos; Attila Köfalvi; Rodrigo A. Cunha; John G. Jones, 2015. NMR Biomed.. 1111 - 1116. 9. 28. 2015. http://dx.doi.org/10.1002/nbm.3355 . 10.1002/nbm.3355 . NMR Biomed.
Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain
Lemos, Cristina; Pinheiro, Bárbara S.; Beleza, Rui O.; Marques, Joana M.; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Rial, Daniel; Köfalvi, Attila, 2015. Purinergic Signalling. 561 - 569. 4. 11. 2015. http://dx.doi.org/10.1007/s11302-015-9474-3 . 10.1007/s11302-015-9474-3 . Purinergic Signalling
Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents
Rafael M. Bitencourt; Alán Alpár; Valentina Cinquina; Samira G. Ferreira; Bárbara S. Pinheiro; Cristina Lemos; Catherine Ledent; et al, 2015. Neurochemistry International. 2015. http://dx.doi.org/10.1016/j.neuint.2015.07.014 . 10.1016/j.neuint.2015.07.014 . Neurochemistry International
Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus
Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al, 2015. European Journal of Neuroscience. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923353859&partnerID=MN8TOARS . 10.1111/ejn.12851 . European Journal of Neuroscience
Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Ferreira, S.G.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; Harkany, T.; et al, 2015. British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology
Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al, 2014. PLoS ONE. 12. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0114216 . 10.1371/journal.pone.0114216 . PLoS ONE
Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain
Köles, L.; Garção, P.; Zádori, Z.S.; Ferreira, S.G.; Pinheiro, B.S.; da Silva-Santos, C.S.; Ledent, C.; Köfalvi, A., 2013. Brain Research Bulletin. 126 - 135. 97. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880816335&partnerID=MN8TOARS . 10.1016/j.brainresbull.2013.06.007 . Brain Research Bulletin
Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder
Pandolfo, P.; Machado, N.J.; Köfalvi, A.; Takahashi, R.N.; Cunha, R.A., 2013. European Neuropsychopharmacology. 317 - 328. 4. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881549136&partnerID=MN8TOARS . 10.1016/j.euroneuro.2012.04.011 . European Neuropsychopharmacology
Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum
Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., 2013. British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology
Presynaptic a2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat
Richter, H.; Teixeira, F.M.; Ferreira, S.G.; Kittel, Á.; Köfalvi, A.; Sperlágh, B., 2012. Neuropharmacology. 784 - 797. 5. 63. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864451017&partnerID=MN8TOARS . 10.1016/j.neuropharm.2012.06.003 . Neuropharmacology
Impaired hippocampal glucoregulation in the cannabinoid CB 1 receptor knockout mice as revealed by an optimized in vitro experimental approach
Lemos, C.; Valério-Fernandes, Â.; Ghisleni, G.C.; Ferreira, S.G.; Ledent, C.; de Ceballos, M.L.; Köfalvi, A., 2012. Journal of Neuroscience Methods. 366 - 373. 2. 204. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855251226&partnerID=MN8TOARS . 10.1016/j.jneumeth.2011.11.028 . Journal of Neuroscience Methods
CB 1 receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus
Duarte, J.M.N.; Ferreira, S.G.; Carvalho, R.A.; Cunha, R.A.; Köfalvi, A., 2012. Neurochemistry International. 1 - 8. 1. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455224661&partnerID=MN8TOARS . 10.1016/j.neuint.2011.10.019 . Neurochemistry International
Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences
Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., 2012. Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
Mulder, J.; Zilberter, M.; Pasquaré, S.J.; Alpár, A.; Schulte, G.; Ferreira, S.G.; Köfalvi, A.; et al, 2011. Brain. 1041 - 1060. 4. 134. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672641&partnerID=MN8TOARS . 10.1093/brain/awr046 . Brain
Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging
De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G., 2011. Cellular and Molecular Neurobiology. 1 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS . 10.1007/s10571-011-9673-6 . Cellular and Molecular Neurobiology
Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina
Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., 2011. Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research
Pre-synaptic adenosine A2A receptors control cannabinoid CB 1 receptor-mediated inhibition of striatal glutamatergic neurotransmission
Martire, A.; Tebano, M.T.; Chiodi, V.; Ferreira, S.G.; Cunha, R.A.; Köfalvi, A.; Popoli, P., 2011. Journal of Neurochemistry. 273 - 280. 2. 116. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650714744&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.07101.x . Journal of Neurochemistry
Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
Pandolfo, Pablo; Silveirinha, Vasco; Santos-Rodrigues, Alexandre dos; Venance, Laurent; Ledent, Catherine; Takahashi, Reinaldo N.; Cunha, Rodrigo A.; Köfalvi, Attila, 2011. European Journal of Pharmacology. 38 - 45. 1-3. 655. 2011. http://dx.doi.org/10.1016/j.ejphar.2011.01.013 . 10.1016/j.ejphar.2011.01.013 . European Journal of Pharmacology
Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.
Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia, 2011. Diabetologia. 458 - 458. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia
Conferenc Paper: Presynaptic A2A adenosine and CB1 cannabinoid receptors inhibit the function of one another at corticostriatal terminals.
Ferreira, Samira G.; Köfalvi, Attila; Cunha, Rodrigo A., 2010. Purinergic Signalling. 44 - 44. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Complex regulation of CB1-mediated effects by activation and blockade of striatal adenosine A2A receptors.
Tebano MT; Martire, A.; Köfalvi, Attila; Chiodi, V.; Ferrante A; Domenici MR; Ferreira, Samira G.; Cunha, Rodrigo A.; Popoli, P., 2010. Purinergic Signalling. 19 - 19. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Chronic caffeine treatment during adolescence improves behavioral flexibility in an animal model of attention deficit hyperactivity disorder.
Pandolfo, P.; Machado NM; Köfalvi, Attila; Takahashi RN; Cunha, Rodrigo A., 2010. Purinergic Signalling. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: Blockade of synaptic adenosine A2A receptor prevents convulsion-induced damage.
Augusto, Elisabete; Paula M. Canas; Lisiane O. Porciúncula; Tiago M. Alfaro; Andrade GM; Köfalvi, Attila; Agostinho PM; Cunha, Rodrigo A., 2010. Purinergic Signalling. 108 - 108. S1. 6. 2010. http://dx.doi.org/10.1007/s11302-010-9187-6 . 10.1007/s11302-010-9187-6 . Purinergic Signalling
Conferenc Paper: When modulators of synaptic plasticity meet at endocannabinoid signalling: comparing dyskinesias with psychosis.
Köfalvi, Attila, 2009. Journal of Neurochemistry. 103 - 104. s1. 110. 2009. http://dx.doi.org/10.1111/j.1471-4159.2009.06064_27.x . 10.1111/j.1471-4159.2009.06064_27.x . Journal of Neurochemistry
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
Ferreira, S.G.; Lomaglio, T.; Avelino, A.; Cruz, F.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2009. Neuropharmacology. 676 - 683. 3. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749097218&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.12.001 . Neuropharmacology
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A., 2009. Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2008.01.003 . Neurobiology of Aging
Conferenc Paper: Dual regulatory role of pre- and post-synaptic adenosine A2A receptors on CB1-mediated effects in the striatum.
Tebano MT; Martire A; Köfalvi, Attila; Chiodi, V.; Domenici MR; Pepponi R; Ferrante A; et al, 2009. Purinergic Signalling. 51 - 51. 1. 6. 2009. http://dx.doi.org/10.1007/s11302-009-9171-1 . 10.1007/s11302-009-9171-1 . Purinergic Signalling
Synthetic cannabinoids inhibit the dopamine transporter whereby increasing stimulated presynaptic net dopamine release in the rat striatum
Attila, Kofalvi, 2009. Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.128 . 10.3389/conf.neuro.01.2009.11.128 . Frontiers in Neuroscience
Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus
Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., 2007. British Journal of Pharmacology. 551 - 563. 4. 151. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Duarte, J.M.N.; Nogueira, C.; Mackie, K.; Oliveira, C.R.; Cunha, R.A.; Köfalvi, A., 2007. Experimental Neurology. 479 - 484. 1. 204. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847311708&partnerID=MN8TOARS . 10.1016/j.expneurol.2006.11.013 . Experimental Neurology
Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments
Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, 2007. Journal of Neurochemistry. 355 - 363. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04386.x . Journal of Neurochemistry
Conferenc Paper: CB1 cannabinoid receptors in the physiopathology of hippocampal glucose homeostasis.
Duarte, JMN; Nogueira, C.; Carvalho; Mackie, K.; Oliveira, CR; Cunha, Rodrigo A.; Köfalvi, Attila, 2007. Journal of Neurochemistry. 115 - 115. s1. 102. 2007. http://dx.doi.org/10.1111/j.0022-3042.2007.04727.x . 10.1111/j.0022-3042.2007.04727.x . Journal of Neurochemistry
CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action
Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., 2006. Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS . 10.1124/mol.106.024661 . Molecular Pharmacology
Erratum: Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (Journal of Neuroscience (June 1, 1999) (4544-4558))
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 2006. Journal of Neuroscience. 47. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751306297&partnerID=MN8TOARS . Journal of Neuroscience
Regulation of neurotransmitter release by presynaptic P2X receptors
Sperlágh, B.; Köfalvi, A.; Papp, L.; Balázsa, T.; Heinrich, A.; Vizi, E.S., 2006. Autonomic and Autacoid Pharmacology. 1. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935368&partnerID=MN8TOARS . Autonomic and Autacoid Pharmacology
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
Köfalvi, A.; Oliveira, C.R.; Cunha, R.A., 2006. Neuroscience Letters. 151 - 156. 1-2. 403. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609298&partnerID=MN8TOARS . 10.1016/j.neulet.2006.04.030 . Neuroscience Letters
Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia
Wirkner, K.; Köfalvi, A.; Fischer, W.; Günther, A.; Franke, H.; Gröger-Arndt, H.; Nörenberg, W.; et al, 2005. Journal of Neurochemistry. 1421 - 1437. 5. 95. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844497440&partnerID=MN8TOARS . 10.1111/j.1471-4159.2005.03465.x . Journal of Neurochemistry
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis
Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., 2005. Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4232-04.2005 . Journal of Neuroscience
Conferenc Paper: The role of presynaptic P2X receptors in the regulation of tritiated NA release from rat hippocampal slices.
Papp, L.; Balázsa, T.; Köfalvi, Attila; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 37 - 37. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
Conferenc Paper: Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the rodent striatum.
Köfalvi, Attila; Ricardo J. Rodrigues; Cunha, Rodrigo A.; Catherine Ledent; Vizi, E. Sylvester; Sperlágh, B., 2004. Fundamental and Clinical Pharmacology. 57 - 57. s1. 18. 2004. http://dx.doi.org/10.1111/j.1472-8206.2004.00260.x . 10.1111/j.1472-8206.2004.00260.x . Fundamental and Clinical Pharmacology
Conferenc Paper: Ischemia induced up-regulation of P2X7 receptors on GABAergic neurons in corticoencephalic cell cultures.
Günther, A.; Köfalvi, Attila; Reinhardt, R.; Franke, F.; Madarász, E.; Vizi, E. Sylvester; Schneider, D.; et al, 2004. European Journal of Neurology. 58 - 58. s2. 11. 2004. http://dx.doi.org/10.1111/j.1468-1331.2004.00919.x . 10.1111/j.1468-1331.2004.00919.x . European Journal of Neurology
Conferenc Paper: Regulation of transmitter release in the CNS by cannabinoid receptors.
Sperlágh, B.; Köfalvi, Attila; E. Sylvester Vizi, 2004. Pharmacology. 141 - 141. 2. 72. 2004. http://dx.doi.org/10.1159/000080185 . 10.1159/000080185 . Pharmacology
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices
Papp, L.; Balázsa, T.; Köfalvi, A.; Erdélyi, F.; Szabó, G.; Vizi, E.S.; Sperlágh, B., 2004. Journal of Pharmacology and Experimental Therapeutics. 973 - 980. 3. 310. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243116404&partnerID=MN8TOARS . 10.1124/jpet.104.066712 . Journal of Pharmacology and Experimental Therapeutics
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action
Köfalvi, A.; Vizi, E.S.; Ledent, C.; Sperlágh, B., 2003. European Journal of Neuroscience. 1973 - 1978. 7. 18. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242539727&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02897.x . European Journal of Neuroscience
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Sperlágh, Beáta; Köfalvi, Attila; Deuchars, Jim; Atkinson, Lucy; J. Milligan, Carol; Buckley, Noel J.; Vizi, E. Sylvester, 2002. Journal of Neurochemistry. 1196 - 1211. 6. 81. 2002. http://dx.doi.org/10.1046/j.1471-4159.2002.00920.x . 10.1046/j.1471-4159.2002.00920.x . Journal of Neurochemistry
Distinct mechanisms underlying a1-adrenoceptor and P2x purinoceptor operated ATP release and contraction in the guinea-pig vas deferens
Sperlágh, B.; Illes, P.; Gerevich, Z.; Köfalvi, A., 2001. Neurochemical Research. 951 - 957. 8-9. 26. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034758043&partnerID=MN8TOARS . 10.1023/A:1012336601854 . Neurochemical Research
Conferenc Paper: ATP releases [3H]GABA from rat hippocampal slices via P2X7 receptor activation.
Köfalvi, Attila; Baranyi M; Vizi ES; Sperlagh, B., 2001. Fundamental and Clinical Pharmacology. 135 - 135. S1. 15. 2001. http://dx.doi.org/10.1046/j.1472-8206.2001.00113.x . 10.1046/j.1472-8206.2001.00113.x . Fundamental and Clinical Pharmacology
Excessive release of [3H]noradrenaline by veratridine and ischemia in spinal cord
Sumiya, Y.; Torigoe, K.; Gerevich, Z.; Köfalvi, A.; Vizi, E.S., 2001. Neurochemistry International. 59 - 63. 1. 39. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034744561&partnerID=MN8TOARS . 10.1016/S0197-0186(00)00124-8 . Neurochemistry International
Conference Paper: Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; Vizi ES; Sperlágh, B., 2000. The Journal of Physiology. 64 - 65. suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . The Journal of Physiology
Long-lasting facilitation of 4-amino-n-[2,3-3H]butyric acid ([3H]GABA) release from rat hippocampal slices by nicotinic receptor activation
Köfalvi, A.; Sperlagh, B.; Zelles, T.; Vizi, E.S., 2000. Journal of Pharmacology and Experimental Therapeutics. 453 - 462. 2. 295. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033775944&partnerID=MN8TOARS . Journal of Pharmacology and Experimental Therapeutics
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Katona, I.; Sperlágh, B.; Maglóczky, Z.; Sántha, E.; Köfalvi, A.; Czirják, S.; Mackie, K.; Vizi, E.S.; Freund, T.F., 2000. Neuroscience. 797 - 804. 4. 100. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638454&partnerID=MN8TOARS . 10.1016/S0306-4522(00)00286-4 . Neuroscience
Cellular Neurophysiology
Köfalvi, Attila; Sántha, E.; Katona, I.; Freund TF; Czirják, S.; Mackie, K.; E. Sylvester Vizi; Sperlagh, B., 2000. Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus. . suppl. 526. 2000. http://dx.doi.org/10.1111/j.1469-7793.2000.tb00269.x . 10.1111/j.1469-7793.2000.tb00269.x . Activation of presynaptically located CB1 cannabinoid receptors decreases the stimulation-induced release of GABA from isolated rat and human hippocampus.
Conference Paper: The Effect of Nicotine on GABA Release from Rat Hippocampal Slices is Mediated via alpha7-Type Homopentameric Neuronal Nicotinic Acetylcholine Receptors
Köfalvi, Attila; E. Sylvester Vizi; Beáta Sperlágh, 1999. Fundamental and Clinical Pharmacology. S1. 13. 1999. http://dx.doi.org/10.1111/j.1472-8206.1999.tb00383.x . 10.1111/j.1472-8206.1999.tb00383.x . Fundamental and Clinical Pharmacology
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
Katona, I.; Sperlágh, B.; Sík, A.; Köfalvi, A.; Vizi, E.S.; Mackie, K.; Freund, T.F., 1999. Journal of Neuroscience. 4544 - 4558. 11. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345621691&partnerID=MN8TOARS . Journal of Neuroscience
5 74 out of 74 Publications
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