Anabela P. Rolo

Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury

Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., Biomedicines. 3. 11. 2023. http://dx.doi.org/10.3390/biomedicines11030948 . 10.3390/biomedicines11030948 . Biomedicines

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Lopes, Cátia R.; Silva, Joana S.; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; et al, International Journal of Molecular Sciences. 8. 24. 2023. http://dx.doi.org/10.3390/ijms24086968 . 10.3390/ijms24086968 . International Journal of Molecular Sciences

Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases

Machado, Ivo F.; Miranda, Raul G.; Dorta, Daniel J.; Rolo, Anabela P.; Palmeira, Carlos M., Antioxidants. 6. 12. 2023. http://dx.doi.org/10.3390/antiox12061212 . 10.3390/antiox12061212 . Antioxidants

PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury

Teixeira da Silva, Rui; Machado, Ivo F.; Teodoro, João S.; Panisello-Roselló, Arnau; Roselló-Catafau, Joan; Rolo, Anabela P.; Palmeira, Carlos M., International Journal of Molecular Sciences. 3. 23. 2022. http://dx.doi.org/10.3390/ijms23031156 . 10.3390/ijms23031156 . International Journal of Molecular Sciences

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, João A.; Coppotelli, Giuseppe; Rolo, Anabela P.; Palmeira, Carlos M.; Ross, Jaime M.; Sinclair, David A., Nature Reviews Endocrinology. 2022. http://dx.doi.org/10.1038/s41574-021-00626-7 . 10.1038/s41574-021-00626-7 . Nature Reviews Endocrinology

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

Teodoro, João S.; Da Silva, Rui T.; Machado, Ivo F.; Panisello-Roselló, Arnau; Roselló-Catafau, Joan; Rolo, Anabela P.; Palmeira, Carlos M., Cells. 4. 11. 2022. http://dx.doi.org/10.3390/cells11040688 . 10.3390/cells11040688 . Cells

The potential role of sestrin 2 in liver regeneration

Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., Free Radical Biology and Medicine. 255 - 267. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027 . 10.1016/j.freeradbiomed.2020.12.027 . Free Radical Biology and Medicine

Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation

Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., Ageing Research Reviews. 67. 2021. http://dx.doi.org/10.1016/j.arr.2021.101309 . 10.1016/j.arr.2021.101309 . published Ageing Research Reviews

miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia

Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P., International Journal of Molecular Sciences. 2. 22. 2021. http://dx.doi.org/10.3390/ijms22020541 . 10.3390/ijms22020541 . International Journal of Molecular Sciences

Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown

Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P., International Journal of Molecular Sciences. 21. 22. 2021. http://dx.doi.org/10.3390/ijms222111738 . 10.3390/ijms222111738 . International Journal of Molecular Sciences

Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics

Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; et al, Nutrients. 12. 13. 2021. http://dx.doi.org/10.3390/nu13124192 . 10.3390/nu13124192 . Nutrients

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.

Gomes P; Viana SD; Nunes S; Rolo AP; Palmeira CM; Reis F, Ageing research reviews. 2020. http://europepmc.org/abstract/med/31740222 . 10.1016/j.arr.2019.100983 . Ageing research reviews

Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes

Teodoro, João S.; Silva, Rui; Aguiar, António; Sobral, Abílio J. F. N.; Rolo, Anabela P.; Palmeira, Carlos M., Toxicology Mechanisms and Methods. 536 - 545. 7. 30. 2020. http://dx.doi.org/10.1080/15376516.2020.1780361 . 10.1080/15376516.2020.1780361 . Toxicology Mechanisms and Methods

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats

Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; et al, Pharmaceutics. 11. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12111094 . 10.3390/pharmaceutics12111094 . Pharmaceutics

Altered mitochondrial metabolism in the insulin-resistant heart

Makrecka-Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, Hélène; Dambrova, Maija; Tepp, Kersti; Puurand, Marju; et al, Acta Physiologica. 3. 228. 2020. http://dx.doi.org/10.1111/apha.13430 . 10.1111/apha.13430 . Acta Physiologica

The influence of dietary conditions in the effects of resveratrol on hepatic steatosis

Milton-Laskibar, I.; Aguirre, L.; Gómez-Zorita, S.; Rolo, A. P.; Portillo, M. P., Food & Function. 9432 - 9444. 11. 11. 2020. http://dx.doi.org/10.1039/d0fo01943g . 10.1039/d0fo01943g . Food & Function

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M., International Journal of Molecular Sciences. 14. 21. 2020. http://dx.doi.org/10.3390/ijms21144896 . 10.3390/ijms21144896 . International Journal of Molecular Sciences

miR-378a: a new emerging microRNA in metabolism

Machado, Ivo F.; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.; Machado IF; Teodoro JS; Palmeira CM; Rolo AP, Cellular and molecular life sciences : CMLS. 2020. http://europepmc.org/abstract/med/31748917 . 10.1007/s00018-019-03375-z . published Cellular and molecular life sciences : CMLS

Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation-an experimental study.

Martins RM; Teodoro JS; Furtado E; Oliveira RC; Tralhão JG; Rolo AP; Palmeira CM, International journal of medical sciences. 2019. http://europepmc.org/abstract/med/31588197 . 10.7150/ijms.34617 . International journal of medical sciences

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.

Palmeira CM; Teodoro JS; Amorim JA; Steegborn C; Sinclair DA; Rolo AP, Free radical biology & medicine. 2019. http://europepmc.org/abstract/med/31349039 . 10.1016/j.freeradbiomed.2019.07.017 . Free radical biology & medicine

Evaluation of bioenergetic and mitochondrial function in liver transplantation.

Martins RM; Teodoro JS; Furtado E; Rolo AP; Palmeira CM; Tralhão JG, Clinical and molecular hepatology. 2019. http://europepmc.org/abstract/med/30897898 . 10.3350/cmh.2018.0087 . Clinical and molecular hepatology

Cytoprotective mechanisms in fatty liver preservation against cold ischemia injury: A comparison between IGL-1 and HTK

Panisello-Roselló, A.; Verde, E.; Lopez, A.; Flores, M.; Folch-Puy, E.; Rolo, A.; Palmeira, C.; et al, International Journal of Molecular Sciences. 2. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041019515&partnerID=MN8TOARS . 10.3390/ijms19020348 . International Journal of Molecular Sciences

Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)”

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, Redox Biology. 694 - 696. 14. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS . 10.1016/j.redox.2017.10.001 . Redox Biology

Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes.

Teodoro JS; Nunes S; Rolo AP; Reis F; Palmeira CM, Frontiers in physiology. 2018. http://europepmc.org/abstract/med/30705633 . 10.3389/fphys.2018.01857 . Frontiers in physiology

Recent insights into mitochondrial targeting strategies in liver transplantation.

Martins RM; Teodoro JS; Furtado E; Rolo AP; Palmeira CM; Tralhão JG, International journal of medical sciences. 2018. http://europepmc.org/abstract/med/29483816 . 10.7150/ijms.22891 . International journal of medical sciences

Addition of berberine to preservation solution in an animal model of ex vivo liver transplant preserves mitochondrial function and bioenergetics from the damage induced by ischemia/reperfusion

Martins, R.M.; Rolo, A.P.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Palmeira, C.M., International Journal of Molecular Sciences. 1. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040938454&partnerID=MN8TOARS . 10.3390/ijms19010284 . International Journal of Molecular Sciences

Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity.

Pereira LC; Cabral Miranda LF; Franco-Bernardes MF; Tasso MJ; Duarte FV; Inácio Varela AT; Rolo AP; Marques Palmeira CM; Dorta DJ, Chemico-biological interactions. 2018. http://europepmc.org/abstract/med/29935161 . 10.1016/j.cbi.2018.06.021 . Chemico-biological interactions

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.

Panisello-Roselló A; Lopez A; Folch-Puy E; Carbonell T; Rolo A; Palmeira C; Adam R; Net M; Roselló-Catafau J, World journal of gastroenterology. 2018. http://europepmc.org/abstract/med/30038465 . 10.3748/wjg.v24.i27.2984 . World journal of gastroenterology

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury.

Panisello-Roselló A; Alva N; Flores M; Lopez A; Castro Benítez C; Folch-Puy E; Rolo A; et al, International Journal of Molecular Sciences. 2018. http://europepmc.org/abstract/med/30131474 . 10.3390/ijms19092479 . International Journal of Molecular Sciences

Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers.

Teodoro JS; Varela AT; Duarte FV; Gomes AP; Palmeira CM; Rolo AP, European journal of clinical investigation. 2018. http://europepmc.org/abstract/med/29603199 . 10.1111/eci.12932 . European journal of clinical investigation

Bioenergetic adaptations of the human liver in the ALPPS procedure - how liver regeneration correlates with mitochondrial energy status.

Alexandrino H; Rolo A; Teodoro JS; Donato H; Martins R; Serôdio M; Martins M; et al, HPB : The Official Journal of the International Hepato Pancreato Biliary Association. 2017. http://europepmc.org/abstract/med/28941575 . 10.1016/j.hpb.2017.08.005 . HPB : The Official Journal of the International Hepato Pancreato Biliary Association

Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats.

Milton-Laskibar I; Aguirre L; Fernández-Quintela A; Rolo AP; Soeiro Teodoro J; Palmeira CM; Portillo MP, Nutrients. 2017. http://europepmc.org/abstract/med/28696376 . 10.3390/nu9070737 . Nutrients

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP, 2017. http://europepmc.org/abstract/med/27848069 . 10.1007/s11302-016-9548-x .

Exposure to BDE-153 induces autophagy in HepG2 cells.

Pereira LC; Duarte FV; Varela ATIF; Rolo AP; Palmeira CMM; Dorta DJ, 2017. http://europepmc.org/abstract/med/28396260 . 10.1016/j.tiv.2017.04.005 .

GSK3ß and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation.

Zaouali MA; Panisello A; Lopez A; Castro C; Folch E; Carbonell T; Rolo A; et al, 2017. http://europepmc.org/abstract/med/28282906 . 10.3390/ijms18030591 .

An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity.

Pereira LC; Duarte FV; Varela AT; Rolo AP; Palmeira CM; Dorta DJ, 2017. http://europepmc.org/abstract/med/27234317 . 10.1016/j.tox.2016.05.022 .

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease

Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A.; et al, Journal of Alzheimer's Disease. 525 - 536. 2. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury.

Rossetti A; Togliatto G; Rolo AP; Teodoro JS; Granata R; Ghigo E; Columbano A; Palmeira CM; Brizzi MF, Cell death discovery. 2017. http://europepmc.org/abstract/med/29354291 . 10.1038/cddiscovery.2017.77 . Cell death discovery

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; et al, Redox Biology. 94 - 162. 13. 2017. http://dx.doi.org/10.1016/j.redox.2017.05.007 . 10.1016/j.redox.2017.05.007 . Redox Biology

Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats.

Teodoro JS; Silva R; Varela AT; Duarte FV; Rolo AP; Hussain S; Palmeira CM, 2016. http://europepmc.org/abstract/med/27171910 . 10.2217/nnm-2016-0049 .

Mitochondrial bioenergetics and posthepatectomy liver dysfunction.

Alexandrino H; Varela AT; Teodoro JS; Martins MA; Rolo AP; Tralhão JG; Palmeira CM; Castro E Sousa F, 2016. http://europepmc.org/abstract/med/27138992 . 10.1111/eci.12639 .

Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, 2016. http://europepmc.org/abstract/med/27790925 . 10.1080/15376516.2016.1222643 .

The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity.

Teodoro JS; Rolo AP; Jarak I; Palmeira CM; Carvalho RA, 2016. http://europepmc.org/abstract/med/27488269 . 10.1002/nbm.3583 .

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

Görlach A; Dimova EY; Petry A; Martínez-Ruiz A; Hernansanz-Agustín P; Rolo AP; Palmeira CM; Kietzmann T, 2015. http://europepmc.org/abstract/med/26339717 . 10.1016/j.redox.2015.08.016 .

Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.

Pantazi E; Zaouali MA; Bejaoui M; Folch-Puy E; Ben Abdennebi H; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. http://europepmc.org/abstract/med/25684941 . 10.3748/wjg.v21.i6.1765 .

Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation

Pantazi, E.; Bejaoui, M.; Zaouali, M.A.; Folch-Puy, E.; Rolo, A.P.; Panisello, A.; Palmeira, C.M.; Roselló-Catafau, J., World Journal of Gastroenterology. 8021 - 8031. 26. 21. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937022268&partnerID=MN8TOARS . 10.3748/wjg.v21.i26.8021 . World Journal of Gastroenterology

Regulation of Mitochondrial Function and its Impact in Metabolic Stress.

Duarte FV; Amorim JA; Palmeira CM; Rolo AP, 2015. http://europepmc.org/abstract/med/25973983 . 10.2174/0929867322666150514095910 .

PPARa Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.

Pantazi E; Folch-Puy E; Bejaoui M; Panisello A; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. http://europepmc.org/abstract/med/26539534 . 10.1155/2015/894679 .

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice.

Teodoro JS; Zouhar P; Flachs P; Bardova K; Janovska P; Gomes AP; Duarte FV; et al, 2014. http://europepmc.org/abstract/med/24310401 . 10.1038/ijo.2013.230 .

High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes.

Teodoro JS; Varela AT; Rolo AP; Palmeira CM, 2014. http://europepmc.org/abstract/med/24842072 . 10.1007/s12263-014-0406-6 .

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

Carmo MR; Menezes AP; Nunes AC; Pliássova A; Rolo AP; Palmeira CM; Cunha RA; Canas PM; Andrade GM, 2014. http://europepmc.org/abstract/med/24508709 . 10.1016/j.neuropharm.2014.01.045 .

The Role of microRNAs in Mitochondria: Small Players Acting Wide.

Duarte FV; Palmeira CM; Rolo AP, 2014. http://europepmc.org/abstract/med/25264560 . 10.3390/genes5040865 .

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

Hubbard, B.P.; Gomes, A.P.; Dai, H.; Li, J.; Case, A.W.; Considine, T.; Riera, T.V.; et al, Science. 1216 - 1219. 6124. 339. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874721105&partnerID=MN8TOARS . 10.1126/science.1231097 . Science

Uncovering the beginning of diabetes: The cellular redox status and oxidative stress as starting players in hyperglycemic damage

Teodoro, J.S.; Gomes, A.P.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M., Molecular and Cellular Biochemistry. 103 - 110. 1-2. 376. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874278002&partnerID=MN8TOARS . 10.1007/s11010-012-1555-9 . Molecular and Cellular Biochemistry

The NAD ratio redox paradox: Why does too much reductive power cause oxidative stress?

Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Mechanisms and Methods. 297 - 302. 5. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878533789&partnerID=MN8TOARS . 10.3109/15376516.2012.759305 . Toxicology Mechanisms and Methods

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier

Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M., Toxicology in Vitro. 2160 - 2168. 8. 27. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS . 10.1016/j.tiv.2013.08.009 . Toxicology in Vitro

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

Rossato, L.G.; Costa, V.M.; Vilas-Boas, V.; De Lourdes Bastos, M.; Rolo, A.; Palmeira, C.; Remião, F., Cardiovascular Toxicology. 413 - 425. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890559945&partnerID=MN8TOARS . 10.1007/s12012-013-9224-0 . Cardiovascular Toxicology

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP; Price NL; Ling AJ; Moslehi JJ; Montgomery MK; Rajman L; White JP; et al, 2013. http://europepmc.org/abstract/med/24360282 . 10.1016/j.cell.2013.11.037 .

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M., Mitochondrion. 637 - 646. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS . 10.1016/j.mito.2013.09.002 . Mitochondrion

Exposure to dibenzofuran triggers autophagy in lung cells

Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Letters. 35 - 42. 1. 209. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84155176935&partnerID=MN8TOARS . 10.1016/j.toxlet.2011.11.029 . Toxicology Letters

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, A.P.; Duarte, F.V.; Nunes, P.; Hubbard, B.P.; Teodoro, J.S.; Varela, A.T.; Jones, J.G.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 185 - 195. 2. 1822. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83255163155&partnerID=MN8TOARS . 10.1016/j.bbadis.2011.10.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M., Free Radical Biology and Medicine. 59 - 69. 1. 52. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84655169624&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2011.10.003 . Free Radical Biology and Medicine

Mitochondrial membrane potential fluctuations associated with the metabolic states of mitochondria

Palmeira, C.M.; Rolo, A.P.; Teodoro JS; Palmeira CM; Rolo AP; Teodoro, João Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto, Methods in Molecular Biology. 89 - 101. 810. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355170970&partnerID=MN8TOARS . 10.1007/978-1-61779-382-0_6 . Methods in Molecular Biology

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N.L.; Gomes, A.P.; Ling, A.J.Y.; Duarte, F.V.; Martin-Montalvo, A.; North, B.J.; Agarwal, B.; et al, Cell Metabolism. 675 - 690. 5. 15. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860477354&partnerID=MN8TOARS . 10.1016/j.cmet.2012.04.003 . Cell Metabolism

Hepatic FXR: Key regulator of whole-body energy metabolism

Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Trends in Endocrinology and Metabolism. 458 - 466. 11. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-82455164172&partnerID=MN8TOARS . 10.1016/j.tem.2011.07.002 . Trends in Endocrinology and Metabolism

Ursodeoxycholic acid treatment of hepatic steatosis: A 13C NMR metabolic study

Nunes, P.M.; Jones, J.G.; Rolo, A.P.; Palmeira, C.M.M.; Carvalho, R.A., NMR in Biomedicine. 1145 - 1158. 9. 24. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054069550&partnerID=MN8TOARS . 10.1002/nbm.1672 . NMR in Biomedicine

Exposure to dibenzofuran affects lung mitochondrial function in vitro

Duarte, F.V.; Simões, A.M.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Mechanisms and Methods. 571 - 576. 8. 21. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053260979&partnerID=MN8TOARS . 10.3109/15376516.2011.576714 . Toxicology Mechanisms and Methods

Regulation of mitochondrial biogenesis in metabolic syndrome

Rolo, A.P.; Gomes, A.P.; Palmeira, C.M., Current Drug Targets. 872 - 878. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955575803&partnerID=MN8TOARS . 10.2174/138945011795529056 . Current Drug Targets

Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective

Teodoro, J.S.; Simões, A.M.; Duarte, F.V.; Rolo, A.P.; Murdoch, R.C.; Hussain, S.M.; Palmeira, C.M., Toxicology in Vitro. 664 - 670. 3. 25. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952039156&partnerID=MN8TOARS . 10.1016/j.tiv.2011.01.004 . Toxicology in Vitro

Fatty liver and ischemia/reperfusion: Are there drugs able to mitigate injury?

Varela, A.T.; Rolo, A.P.; Palmeira, C.M., Current Medicinal Chemistry. 4987 - 5002. 32. 18. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054860029&partnerID=MN8TOARS . 10.2174/092986711797535164 . Current Medicinal Chemistry

Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3ß and mitochondrial permeability transition

Varela, A.T.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P., Mitochondrion. 456 - 463. 5. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955424602&partnerID=MN8TOARS . 10.1016/j.mito.2010.04.006 . Mitochondrion

Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics

Simes, A.M.; Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Mechanisms and Methods. 1 - 6. 1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77149123078&partnerID=MN8TOARS . 10.3109/15376510903527916 . Toxicology Mechanisms and Methods

Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: The key role of ATPsynthase and mitochondrial permeability transition

Rolo, A.P.; Teodoro, J.S.; Peralta, C.; Rosello-Catafau, J.; Palmeira, C.M., Transplant International. 1081 - 1090. 11. 22. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349668693&partnerID=MN8TOARS . 10.1111/j.1432-2277.2009.00916.x . Transplant International

Biosensor plates detect mitochondrial physiological regulators and mutations in vivo

Rolo, A.P.; Palmeira, C.M.; Cortopassi, G.A., Analytical Biochemistry. 176 - 178. 1. 385. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-57749174647&partnerID=MN8TOARS . 10.1016/j.ab.2008.10.002 . Analytical Biochemistry

Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction

Varela, A.T.; Gomes, A.P.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M., Toxicology and Applied Pharmacology. 179 - 185. 2. 233. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56049123388&partnerID=MN8TOARS . 10.1016/j.taap.2008.08.005 . Toxicology and Applied Pharmacology

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

Teodoro, J.S.; Rolo, A.P.; Duarte, F.V.; Simões, A.M.; Palmeira, C.M., Mitochondrion. 367 - 376. 5-6. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949089576&partnerID=MN8TOARS . 10.1016/j.mito.2008.07.008 . Mitochondrion

Hyperglycemia decreases mitochondrial function: The regulatory role of mitochondrial biogenesis

Palmeira, C.M.; Rolo, A.P.; Berthiaume, J.; Bjork, J.A.; Wallace, K.B., Toxicology and Applied Pharmacology. 214 - 220. 2. 225. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36048941086&partnerID=MN8TOARS . 10.1016/j.taap.2007.07.015 . Toxicology and Applied Pharmacology

Insulin attenuates diabetes-related mitochondrial alterations: A comparative study

Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S., Medicinal Chemistry. 299 - 308. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS . 10.2174/157340606776930754 . Medicinal Chemistry

Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress

Rolo, A.P.; Palmeira, C.M., Toxicology and Applied Pharmacology. 167 - 178. 2. 212. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645765312&partnerID=MN8TOARS . 10.1016/j.taap.2006.01.003 . Toxicology and Applied Pharmacology

Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis

Teodoro, J.; Rolo, A.P.; Oliveira, P.J.; Palmeira, C.M., FEBS Letters. 2153 - 2157. 8. 580. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645241135&partnerID=MN8TOARS . 10.1016/j.febslet.2006.02.078 . FEBS Letters

Mitochondrially-mediated toxicity of bile acids

Palmeira, C.M.; Rolo, A.P., Toxicology. 1 - 15. 1-3. 203. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444311570&partnerID=MN8TOARS . 10.1016/j.tox.2004.06.001 . Toxicology

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function

Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Monteiro, P.; Gonçalves, L.; Providência, L.A.; Palmeira, C.M.; Moreno, A.J.M., Revista Portuguesa de Cardiologia. 1291 - 1298. 10. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644236410&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: The switch between apoptosis and necrosis

Rolo, A.P.; Palmeira, C.M.; Holy, J.M.; Wallace, K.B., Toxicological Sciences. 196 - 204. 1. 79. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442644019&partnerID=MN8TOARS . 10.1093/toxsci/kfh078 . Toxicological Sciences

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats

Oliveira, P.J.; Seica, R.; Santos, D.L.; Rolo, A.P.; Sardao, V.A.; Ferreira, F.M.L.; Palmeira, C.M.; Santos, M.S.; Moreno, A.J.M., Mitochondrion. 337 - 345. 6. 3. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484378&partnerID=MN8TOARS . 10.1016/j.mito.2004.02.005 . Mitochondrion

Carvedilol Inhibits the Mitochondrial Permeability Transition by an Antioxidant Mechanism

Oliveira, P.J.; Esteves, T.; Rolo, A.P.; Palmeira, C.M.; Moreno, A.J.M., Cardiovascular Toxicology. 11 - 20. 1. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942486470&partnerID=MN8TOARS . 10.1385/CT:4:1:11 . Cardiovascular Toxicology

Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol

Rolo, Anabela P.; Oliveira, Paulo J.; Moreno, Antonio J.; Palmeira, Carlos M.; Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.; Palmeira, C.M., Mitochondrion. 305 - 311. 4. 2. 2003. http://dx.doi.org/10.1016/s1567-7249(03)00007-2 . 10.1016/s1567-7249(03)00007-2 . Mitochondrion

Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J.M., Journal of Investigative Medicine. 86 - 94. 2. 51. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037338705&partnerID=MN8TOARS . Journal of Investigative Medicine

Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition

Oliveira, P.J.; Esteves, T.; Rolo, A.P.; Monteiro, P.; Gonçalves, L.; Palmeira, C.M.; Moreno, A.J., Revista Portuguesa de Cardiologia. 55 - 62. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Cholestasis induced by chronic treatment with a-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics

Ferreira, F. M.; Oliveira, P. J.; Rolo, A. P.; Santos, M. S.; Moreno, A. J.; da Cunha, M. F.; Seiça, R.; Palmeira, C. M., Archives of Toxicology. 194 - 200. 4. 77. 2003. http://dx.doi.org/10.1007/s00204-003-0441-3 . 10.1007/s00204-003-0441-3 . Archives of Toxicology

Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease?

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J., Revista Portuguesa de Cardiologia. 67 - 75. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Pameira, C.M., Hepatology Research. 217 - 224. 3. 26. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042167601&partnerID=MN8TOARS . 10.1016/S1386-6346(03)00108-6 . Hepatology Research

Mitochondrially mediated synergistic cell killing by bile acids

Rolo, A.P.; Palmeira, C.M.; Wallace, K.B., Biochimica et Biophysica Acta - Molecular Basis of Disease. 127 - 132. 1. 1637. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037454711&partnerID=MN8TOARS . 10.1016/S0925-4439(02)00224-7 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Synthesis and characterization of beta tricalcium phosphate

Destainville, A.; Rolo, A.; Champion, E.; Bernache-Assollant, D., Key Engineering Materials. 489 - 492. 240-242. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037247010&partnerID=MN8TOARS . Key Engineering Materials

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with a-naphthyl-isothiocyanate (ANIT)

Palmeira, C.M.; Ferreira, F.M.; Rolo, A.P.; Oliveira, P.J.; Santos, M.S.; Moreno, A.J.; Cipriano, M.A.; Martins, M.I.; Seiça, R., Toxicology. 185 - 196. 3. 190. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042133192&partnerID=MN8TOARS . 10.1016/S0300-483X(03)00163-X . Toxicology

Reduction in cardiac mitochondrial calcium loading capacity is observable during a-naphthylisothiocyanate-induced acute cholestasis: A clue for hepatic-derived cardiomyopathies?

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J., Biochimica et Biophysica Acta - Molecular Basis of Disease. 39 - 45. 1. 1637. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037454702&partnerID=MN8TOARS . 10.1016/S0925-4439(02)00212-0 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats

Oliveira, P.J.; Seiça, R.; Coxito, P.M.; Rolo, A.P.; Palmeira, C.M.; Santos, M.S.; Moreno, A.J.M., FEBS Letters. 511 - 514. 3. 554. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242541631&partnerID=MN8TOARS . 10.1016/S0014-5793(03)01233-X . FEBS Letters

Interactions of combined bile acids on hepatocyte viability: Cytoprotection or synergism

Rolo, A.P.; Palmeira, C.M.; Wallace, K.B., Toxicology Letters. 197 - 203. 3. 126. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037033967&partnerID=MN8TOARS . 10.1016/S0378-4274(01)00464-7 . Toxicology Letters

Impact of diabetes on induction of the mitochondrial permeability transition.

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Sardão, V.; Monteiro, P.; Gonçalves, L.; Providência, L.; et al, Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 759 - 766. 6. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036616238&partnerID=MN8TOARS . Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion?

Oliveira, P.J.; Rolo, A.P.; Monteiro, P.; Conçalves, L.; Palmeira, C.M.; Moreno, A.J., Revista Portuguesa de Cardiologia. 1447 - 1455. 12. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis

Rolo, A.P.; Oliveira, P.J.; Seiça, R.; Santos, M.S.; Moreno, A.J.; Palmeira, C.M., Journal of Investigative Medicine. 193 - 200. 3. 50. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS . Journal of Investigative Medicine

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of a-naphthylisothiocyanate

Rolo, A.P.; Oliveira, P.J.; Seiça, R.; Santos, M.S.; Moreno, A.J.; Palmeira, C.M., Toxicology and Applied Pharmacology. 20 - 26. 1. 182. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036070550&partnerID=MN8TOARS . 10.1006/taap.2002.9434 . Toxicology and Applied Pharmacology

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury

Oliveira, P.J.; Rolo, A.P.; Palmeira, C.M.; Moreno, A.J.M., Cardiovascular Toxicology. 205 - 213. 3. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS . 10.1385/CT:1:3:205 . Cardiovascular Toxicology

Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., Biochemical Pharmacology. 1449 - 1454. 11. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00620-7 . Biochemical Pharmacology

Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?

Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M., Life Sciences. 123 - 132. 2. 69. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS . 10.1016/S0024-3205(01)01109-2 . Life Sciences

Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore

Oliveira, P.J.; Coxito, P.M.; Rolo, A.P.; Santos, D.L.; Palmeira, C.M.; Moreno, A.J.M., European Journal of Pharmacology. 231 - 237. 3. 412. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS . 10.1016/S0014-2999(01)00745-2 . European Journal of Pharmacology

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate

Oliveira, P.J.; Rolo, A.P.; Seiãça, R.; Palmeira, C.M.; Santos, M.S.; Moreno, A.J.M., Bioscience Reports. 45 - 53. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034905572&partnerID=MN8TOARS . Bioscience Reports

Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., Bioscience Reports. 73 - 80. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS . 10.1023/A:1010438202519 . Bioscience Reports

Cholestasis and mitochondrial dysfunction: A review

Rolo, A.P.; Palmeira, C.M., Toxic Substance Mechanisms. 83 - 98. 2. 19. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034458883&partnerID=MN8TOARS . 10.1080/10769180052008878 . Toxic Substance Mechanisms

Bile acids affect liver mitochondrial bioenergetics: Possible relevance for cholestasis therapy

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., Toxicological Sciences. 177 - 185. 1. 57. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033852206&partnerID=MN8TOARS . Toxicological Sciences