Ana Maria Sequeira Cardoso

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Information about journal articles, updated at 24-09-2023, from platform CIÊNCIAVITAE.

IL-4 Shapes Microglia-Dependent Pruning of the Cerebellum During Postnatal Development

Guedes, Joana R.; Ferreira, Pedro A.; Costa, Jéssica; Laranjo, Mariana; Reis, Tiago; Cardoso, Ana Maria; Lebre, Carolina; et al, SSRN Electronic Journal. 2023. . 10.2139/ssrn.4281069 . under revision SSRN Electronic Journal

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations

Ana Rafaela Oliveira; Solange Martins; Giuseppe Cammarata; Mariana Martins; Ana Maria Cardoso; Maria Rosário Almeida; Maria do Carmo Macário; et al, Biomedicines. 2022. . 10.3390/biomedicines10081905 . Biomedicines

Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition

Catarina M. Morais; Ana M. Cardoso; Ana Rita D. Araújo; Ana Reis; Pedro Domingues; Maria Rosário M. Domingues; Maria C. Pedroso de Lima; Amália S. Jurado, International Journal of Molecular Sciences. 2022. . 10.3390/ijms232113014 . International Journal of Molecular Sciences

Peripheral inflammatory markers during an acute bacterial infection in older patients with and without cognitive dysfunction: a case control study

Regueira, Patrícia; Silva, Ana Rita; Cardoso, Ana Luísa; Cardoso, Ana Maria; et al., Brain Behavior and Immunity. 2022. submitted Brain Behavior and Immunity

MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance

Cardoso, Ana M; Morais, Catarina M; Sousa, Madalena; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S, Human Molecular Genetics. 2315 - 2331. 23. 30. 2021. . 10.1093/hmg/ddab193 . Human Molecular Genetics

The old guard: Age-related changes in microglia and their consequences

Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso, Mechanisms of Ageing and Development. 111512 - 111512. 197. 2021. . 10.1016/j.mad.2021.111512 . Mechanisms of Ageing and Development

Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib

Cardoso, A.M.; Morais, C.M.; Pena, F.; Marante, T.; Cunha, P.P.; Jurado, A.S.; Pedroso de Lima, M.C., Human Molecular Genetics. 2021. . 10.1093/hmg/ddab011 . Human Molecular Genetics

Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through a miR-302a-dependent mechanism

Cardoso, A.M.; Morais, C.M.; Rebelo, O.; Tão, H.; Barbosa, M.; Pedroso de Lima, M.C.; Jurado, A.S., Human Molecular Genetics. 2021. . 10.1093/hmg/ddab009 . Human Molecular Genetics

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; et al, Materials. 3. 13. 2020. . 10.3390/ma13030513 . published Materials

MiRNA-31 improves cognition and abolishes amyloid-ß pathology by targeting APP and BACE1 in an animal model of Alzheimer’s disease

Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al, Molecular Therapy - Nucleic Acids. 2020. . 10.1016/j.omtn.2020.01.010 . accepted Molecular Therapy - Nucleic Acids

Lauroylated Histidine-Enriched S413-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells

Morais, Catarina M.; Cardoso, Ana M.; Aguiar, Luísa; Vale, Nuno; Nóbrega, Clévio; Zuzarte, Mónica; Gomes, Paula; Pedroso de Lima, Maria C.; Jurado, Amália S., Pharmaceutical Research. 10. 37. 2020. . 10.1007/s11095-020-02904-x . Pharmaceutical Research

Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes

Faria, Rúben; Albuquerque, Tânia; Neves, Ana R.; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana, Journal of Molecular Liquids. 316. 2020. . 10.1016/j.molliq.2020.113873 . Journal of Molecular Liquids

Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma

Catarina M Morais; Pedro P Cunha; Tânia Melo; Ana M Cardoso; Pedro Domingues; M Rosário Domingues; Maria C Pedroso de Lima; Amália S Jurado, Human Molecular Genetics. 2019. . 10.1093/hmg/ddz152 . Human Molecular Genetics

A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin

Pinto, Sara M. A.; Calvete, Mário J. F.; Ghica, Mariana E.; Soler, Sérgio; Gallardo, Iluminada; Pallier, Agnès; Laranjo, Mariana B.; et al, Dalton Transactions. 3249 - 3262. 10. 48. 2019. . 10.1039/c8dt04775h . Dalton Transactions

MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy

Ana M S Cardoso; Madalena Sousa; Catarina M Morais; Liliana R Oancea-Castillo; Anne Régnier-Vigouroux; Olinda Rebelo; Hermínio Tão; et al, Human Molecular Genetics. 2019. . 10.1093/hmg/ddz099 . Human Molecular Genetics

Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions

Morais, Catarina M.; Cardoso, Ana M.; Cunha, Pedro P.; Aguiar, Luísa; Vale, Nuno; Lage, Emílio; Pinheiro, Marina; et al, Biochimica et Biophysica Acta (BBA) - Biomembranes. 2619 - 2634. 12. 1860. 2018. . 10.1016/j.bbamem.2018.10.002 . Biochimica et Biophysica Acta (BBA) - Biomembranes

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors

Cunha, P.P.; Costa, P.M.; Morais, C.M.; Lopes, I.R.; Cardoso, A.M.; Cardoso, A.L.; Mano, M.; Jurado, A.S.; Pedroso De Lima, M.C.P., Human Molecular Genetics. 4375 - 4387. 22. 26. 2017. . 10.1093/hmg/ddx323 . Human Molecular Genetics

miRNAs: New biomarkers and therapeutic targets in dementia

Viegas, A.T.B.; Guedes, J.R.; Oliveira, A.R.; Cardoso, A.M.S.; Cardoso, A.L.C., Current Pharmaceutical Design. 669 - 692. 5. 23. 2017. . 10.2174/1381612823666170111094702 . Current Pharmaceutical Design

Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes

Cruz, R.Q.; Morais, C.M.; Cardoso, A.M.; Silva, S.G.; Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., European Journal of Pharmaceutics and Biopharmaceutics. 7 - 18. 104. 2016. . 10.1016/j.ejpb.2016.04.014 . European Journal of Pharmaceutics and Biopharmaceutics

The quest for biocompatible phthalocyanines for molecular imaging: Photophysics, relaxometry and cytotoxicity studies

Pinto, S.M.A.; Tomé, V.A.; Calvete, M.J.F.; Pereira, M.M.; Burrows, H.D.; Cardoso, A.M.S.; Pallier, A.; et al, Journal of Inorganic Biochemistry. 50 - 59. 154. 2016. . 10.1016/j.jinorgbio.2015.10.013 . Journal of Inorganic Biochemistry

MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

Guedes, J.R.; Santana, I.; Cunha, C.; Duro, D.; Almeida, M.R.; Cardoso, A.M.; de Lima, M.C.P.; Cardoso, A.L., Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 7 - 17. 3. 2016. . 10.1016/j.dadm.2015.11.004 . Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression

Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., Molecular Pharmaceutics. 716 - 730. 3. 12. 2015. . 10.1021/mp5005349 . Molecular Pharmaceutics

New serine-derived gemini surfactants as gene delivery systems

Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S., European Journal of Pharmaceutics and Biopharmaceutics. 347 - 356. 89. 2015. . 10.1016/j.ejpb.2014.12.013 . European Journal of Pharmaceutics and Biopharmaceutics

Sustained release of naltrexone from Poly(N-Isopropylacrylamide) microgels

Kjøniksen, A.-L.; Calejo, M.T.; Zhu, K.; Cardoso, A.M.S.; De Lima, M.C.P.; Jurado, A.S.; Nyström, B.; Sande, S.A., Journal of Pharmaceutical Sciences. 227 - 234. 1. 103. 2014. . 10.1002/jps.23780 . Journal of Pharmaceutical Sciences

Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions

Cardoso, A.M.; Morais, C.M.; Silva, S.G.; Marques, E.F.; De Lima, M.C.P.; Jurado, M.A.S., International Journal of Pharmaceutics. 57 - 69. 1-2. 474. 2014. . 10.1016/j.ijpharm.2014.08.011 . International Journal of Pharmaceutics

Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery

Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B., Molecular Pharmaceutics. 819 - 827. 3. 11. 2014. . 10.1021/mp400510a . Molecular Pharmaceutics

Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery

Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 2653 - 2666. 7. 10. 2013. . 10.1021/mp400078h . Molecular Pharmaceutics

Synthesis of gemini surfactants and evaluation of their interfacial and cytotoxic properties: Exploring the multifunctionality of serine as headgroup

Silva, S.G.; Alves, C.; Cardoso, A.M.S.; Jurado, A.S.; Pedroso De Lima, M.C.; Vale, M.L.C.; Marques, E.F., European Journal of Organic Chemistry. 1758 - 1769. 9. 2013. . 10.1002/ejoc.201201396 . European Journal of Organic Chemistry

In vitro cytotoxicity of a thermoresponsive gel system combining ethyl(hydroxyethyl) cellulose and lysine-based surfactants

Calejo, M.T.; Cardoso, A.M.S.; Marques, E.F.; Araújo, M.J.; Kjøniksen, A.-L.; Sande, S.A.; de Lima, M.C.P.; Jurado, A.S.; Nyström, B., Colloids and Surfaces B: Biointerfaces. 682 - 686. 102. 2013. . 10.1016/j.colsurfb.2012.09.033 . Colloids and Surfaces B: Biointerfaces

Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications

Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C., Current Pharmaceutical Design. 2895 - 2923. 16. 19. 2013. . 10.2174/1381612811319160006 . Current Pharmaceutical Design

Temperature-responsive cationic block copolymers as nanocarriers for gene delivery

Calejo, M.T.; Cardoso, A.M.S.; Kjøniksen, A.-L.; Zhu, K.; Morais, C.M.; Sande, S.A.; Cardoso, A.L.; et al, International Journal of Pharmaceutics. 105 - 114. 1. 448. 2013. . 10.1016/j.ijpharm.2013.03.028 . International Journal of Pharmaceutics

Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants

Calejo, M.T.; Kjoniksen, A.-L.; Pinazo, A.; Pérez, L.; Cardoso, A.M.S.; Pedroso De Lima, M.C.; Jurado, A.S.; Sande, S.A.; Nyström, B., International Journal of Pharmaceutics. 454 - 462. 1-2. 436. 2012. . 10.1016/j.ijpharm.2012.07.018 . International Journal of Pharmaceutics

S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization

Cardoso, A.M.S.; Trabulo, S.; Cardoso, A.L.; Lorents, A.; Morais, C.M.; Gomes, P.; Nunes, C.; et al, Biochimica et Biophysica Acta - Biomembranes. 877 - 888. 3. 1818. 2012. . 10.1016/j.bbamem.2011.12.022 . Biochimica et Biophysica Acta - Biomembranes

Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents

Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 1120 - 1131. 4. 8. 2011. . 10.1021/mp100426e . Molecular Pharmaceutics

Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency

Cardoso, A.M.S.; Faneca, H.; Almeida, J.A.S.; Pais, A.A.C.C.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S., Biochimica et Biophysica Acta - Biomembranes. 341 - 351. 1. 1808. 2011. . 10.1016/j.bbamem.2010.09.026 . Biochimica et Biophysica Acta - Biomembranes

All projects

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Information of exclusive responsibility of the researcher 24-09-2023 , from platform CIÊNCIAVITAE.

2023/03/01 - 2026/02/28

Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits



Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2022/05/01 - 2025/04/30

Astrocytes dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies


Co-Principal Investigator (Co-PI)

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2023/12/31

Disease modelling of frontotemporal dementia in human brain organoids



Funders: Fundação para a Ciência e a Tecnologia

2019/01/01 - 2020/12/31

Projecto estratégico UID/NEU/04539/2019



2017/01/01 - 2020/12/31

BrainHealth2020 - Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders



2017/01/01 - 2019/12/31

Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy



2016/01/01 - 2018/12/31

A lipidomic and miRNA-based strategy for glioblastoma treatment



2015/01/02 - 2019/01/14

Targeting non-coding RNAs involved in the regulation of glycolysis/oxidative phosphorylation of glioblastoma cells towards tumor sensitization to chemotherapy


Post-doc Fellow


Funders: Fundação para a Ciência e a Tecnologia

2013/01/01 - 2015/12/31

Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid­based nanosystem for systemic delivery



2013/01/01 - 2014/12/31

Projecto estratégico CNC/UC: PEst­C/SAU/LA0001/2013 – LA1

CNC/UC: PEst­C/SAU/LA0001/2013 – LA1


2011/01/01 - 2012/12/31

Projecto estratégico CNC/UC: PEst­C/SAU/LA0001/2011 - LA1

CNC/UC: PEst­C/SAU/LA0001/2011 - LA1



2010/05/03 - 2014/04/30

Interaction of Lipoplexes with Cellular Membranes: a Biophysical Approach to Gene Delivery


Funders: Fundação para a Ciência e a Tecnologia

2009/09/01 - 2010/04/30

Development of a novel approach for anti-tumoral therapy based on the S4(13)-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids


Research Technician Fellow


Funders: Fundação para a Ciência e a Tecnologia

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