Armanda Emanuela Castro e Santos

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Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

New BACE1 chimeric peptide inhibitors selectively prevent AßPP-ß cleavage decreasing Aß production and accumulation in AD models

Santos, Armanda E, Journal of Alzheimers Disease. 2020. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200381 . 10.3233/JAD-200381 . Journal of Alzheimers Disease

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Santos, Armanda, International Journal of Molecular Sciences. 2020. https://www.mdpi.com/1422-0067/21/20/7791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Judite R. M. Coimbra; Salete J. Baptista; Teresa C. P. Dinis; Maria M. C. Silva; Paula I. Moreira; Armanda E. Santos; Jorge A. R. Salvador, Biomolecules. 535 - 535. 4. 10. 2020. https://doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

An overview of glutaminyl cyclase inhibitors for Alzheimer's disease

Coimbra, J.R.M.; Sobral, P.J.M.; Santos, A.E.; Moreira, P.I.; Salvador, J.A.R., Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076529321&partnerID=MN8TOARS . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Is Alzheimer's disease an inflammasomopathy?

Pereira, C.F.; Santos, A.E.; Moreira, P.I.; Pereira, A.C.; Sousa, F.J.; Cardoso, S.M.; Cruz, M.T., Ageing Research Reviews. 56. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072809334&partnerID=MN8TOARS . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Polyphenolic characterization and bioactivity of an Oxalis pes-caprae L. leaf extract.

Santos, Armanda, Natural Product Research. 2018. https://www.ncbi.nlm.nih.gov/pubmed/28627294 . 10.1080/14786419.2017.1335728 . Natural Product Research

Highlights in BACE1 inhibitors for Alzheimer's disease treatment

Coimbra, J.R.M.; Marques, D.F.F.; Baptista, S.J.; Pereira, C.M.F.; Moreira, P.I.; Dinis, T.C.P.; Santos, A.E.; Salvador, J.A.R., Frontiers in Chemistry. MAY. 6. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048225310&partnerID=MN8TOARS . 10.3389/fchem.2018.00178 . Frontiers in Chemistry

The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells

Mariana P.C. Ribeiro; Armanda E. Santos; José B.A. Custódio, Chemico-Biological Interactions. 176 - 184. 277. 2017. https://doi.org/10.1016/j.cbi.2017.09.017 . 10.1016/j.cbi.2017.09.017 . Chemico-Biological Interactions

Ionotropic glutamate receptor antagonists and cancer therapy: time to think out of the box?

Ribeiro, M.P.C.; Custódio, J.B.A.; Santos, A.E., Cancer Chemotherapy and Pharmacology. 219 - 225. 2. 79. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984821839&partnerID=MN8TOARS . 10.1007/s00280-016-3129-0 . Cancer Chemotherapy and Pharmacology

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Rethinking tamoxifen in the management of melanoma: New answers for an old question

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., European Journal of Pharmacology. 372 - 378. 764. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937509486&partnerID=MN8TOARS . 10.1016/j.ejphar.2015.07.023 . European Journal of Pharmacology

Mitochondria: The gateway for tamoxifen-induced liver injury

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., Toxicology. 10 - 18. 323. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902357447&partnerID=MN8TOARS . 10.1016/j.tox.2014.05.009 . Toxicology

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

Interplay between estrogen and retinoid signaling in breast cancer - Current and future perspectives

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., Cancer Letters. 17 - 24. 1. 353. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908364519&partnerID=MN8TOARS . 10.1016/j.canlet.2014.07.009 . Cancer Letters

The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells

Ribeiro, M.P.C.; Nunes-Correia, I.; Santos, A.E.; Custódio, J.B.A., Experimental Cell Research. 288 - 296. 2. 321. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895063788&partnerID=MN8TOARS . 10.1016/j.yexcr.2013.11.002 . Experimental Cell Research

Effects of all-trans-retinoic acid on the permeability transition and bioenergetic functions of rat liver mitochondria in combination with endoxifen

Ribeiro, M.P.C.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A., Life Sciences. 96 - 107. 2-3. 93. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880250995&partnerID=MN8TOARS . 10.1016/j.lfs.2013.05.027 . Life Sciences

The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency

Ribeiro, M.P.C.; Silva, F.S.G.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A., Toxicology and Applied Pharmacology. 104 - 112. 1. 267. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872252817&partnerID=MN8TOARS . 10.1016/j.taap.2012.12.012 . Toxicology and Applied Pharmacology

The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells

Ribeiro, M.P.C.; Silva, F.S.G.; Paixão, J.; Santos, A.E.; Custódio, J.B.A., European Journal of Pharmacology. 354 - 362. 1-3. 715. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885471345&partnerID=MN8TOARS . 10.1016/j.ejphar.2013.04.038 . European Journal of Pharmacology

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons

Santos, A.E.; Carvalho, A.L.; Lopes, M.C.; Carvalho, A.P., Journal of Neuroscience Research. 643 - 655. 4. 66. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889524&partnerID=MN8TOARS . 10.1002/jnr.10036 . Journal of Neuroscience Research

Sulfonated Chloroaluminum Phthalocyanine Incorporates into Human Plasma Lipoproteins: Photooxidation of Low-Density Lipoproteins

Santos, A.E.; Laranjinha, J.A.N.; Almeida, L.M., Photochemistry and Photobiology. 378 - 385. 4. 67. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032040364&partnerID=MN8TOARS . Photochemistry and Photobiology

Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes

Santos, A.E.; Carvalho, C.M.; Macedo, T.A.; Carvalho, A.P., Neurochemistry International. 397 - 406. 4-5. 27. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028981911&partnerID=MN8TOARS . 10.1016/0197-0186(95)00021-Y . Neurochemistry International

All projects

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Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2018 - 2022

InPaCtus - Innovative Products and Technologies from Eucalyptus

COMPETE2020 nº 21874

Researcher

2018 - 2021

Role of anthocyanins from Portuguese blueberries on gut-to-brain connection in autism spectrum disorder by using in vitro and in vivo models

POCI-01-0145-FEDER-029089

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

The ups and downs of cellular stress: the MAM hypothesis for Bipolar disorder pathophysiology

CENTRO-01-0145-FEDER-028214

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease

CENTRO-01-0145-FEDER-029369

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2017/07 - 2018/07

New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors

Bolsa de Investigação Edgar Cruz e Silva da edição 2016-2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Grupo de Estudos de Envelhecimento Cerebral e Demências com o patrocínio da Santa Casa da Misericórdia de Lisboa

2017 - 2018

Caracterização do potencial bioactivo dos recursos hídricos termais da região centro

CENTRO-04-3928-FEDER-000010

Researcher

2017 - 2018

Caracterização do potencial bioactivo dos recursos hídricos termais da região centro

CENTRO-04-3928-FEDER-000010

Researcher

2017 - 2020

HealthyAging2020

CENTRO-01-0145-FEDER-000012

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2016 - 2019

Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos (Drugs2CAD)

CENTRO-01-0247-FEDER-003269

Researcher

Funders: Centro 2020 Regional Operational Programme; COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese

2013/06 - 2015/11

Tackling Alzheimer's Disease with a new peptide inhibitor of BACE1

PTDC/NEU-SCC/1351/2012

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2015

Healthy ageing with innovative functional foods/leads for degenerative and metabolic diseases

INOVAFUNAGEING

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2015

New Strategies to Manage Brain Diseases

CENTRO-07-ST24-FEDER-002002

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2012 - 2015

Desenvolvimento de um novo fármaco para o tratamento da doença de Alzheimer

INC_2014_09_002_5645

Principal investigator

Funders: INOV.C - Sistemas de Bolsas de Ignição do Programa Estratégico Inov C, funded by QREN

2008 - 2011

Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type

PTDC/SAU-NEU/099440/2008

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2007 - 2009

Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways

Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Biogen Portugal

2006 - 2009

Regulation of AMPA receptors by hyperglycemia in the retina

PTDC/SAL-NEU/71228/2006

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2006 - 2009

Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors

PTDC/BIA-BCM/71789/2006

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2004 - 2007

ATP and diabetic retinopathy: role on microglia regulation and on neuronal cell death

POCI/SAU-NEU/59003/2004

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2004 - 2007

Molecular determinants of ataxin-3 aggregation and toxicity in Machado-joseph’s disease

POCI/SAU MMO/60156/2004

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2004 - 2007

Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors

POCI/SAU-NEU/58955/2004

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2004

Expression and functional characteristics of native and truncated forms of AMPA type glutamate receptor subunits

POCTI/BCI/39127/2001

Researcher

Funders: Fundação para a Ciência e a Tecnologia

1998 - 2002

Glutamate neurotoxicity in retina cells: post-receptor events

SAU/14120/98

Researcher

Funders: Fundação para a Ciência e a Tecnologia

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