Ângelo Tomé

Team icon



Show less

Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

Increased ATP release and CD73-mediated adenosine A<sub>2A</sub> receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Augusto, E.; Gonçalves, F.Q.; Real, J.E.; Silva, H.B.; Pochmann, D.; Silva, T.S.; Matos, M.; et al, Neurobiology of Disease. 157. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114384142&partnerID=MN8TOARS . 10.1016/j.nbd.2021.105441 . Neurobiology of Disease

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al, Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS . 10.1038/s41598-021-89964-0 . Scientific Reports

Convergence of adenosine and GABA signaling for synapse stabilization during development

Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . Science

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Queiroz; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tome, Angelo; Agostinho, Paula; Cunha, Rodrigo A., Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.639322 . 10.3389/fncel.2021.639322 . Frontiers in Cellular Neuroscience

Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia

Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique; Tome, Angelo; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2021. http://dx.doi.org/10.1152/ajpregu.00295.2020 . 10.1152/ajpregu.00295.2020 . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Use of knockout mice to explore CNS effects of adenosine

Cátia R. Lopes; Vanessa S. Lourenço; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Biochemical Pharmacology. 114367 - 114367. 2020. https://doi.org/10.1016/j.bcp.2020.114367 . 10.1016/j.bcp.2020.114367 . Biochemical Pharmacology

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome

Moreira-de-Sá, Ana; Gonçalves, Francisco Queiroz; Lopes, João; Silva, Henrique; Tome, Angelo; Cunha, Rodrigo A.; Canas, PM, Neurobiology of Disease. 146. 2020. http://dx.doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of Disease

Role of Adenosine in Epilepsy and Seizures

Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Tomé, Ângelo R.; Cunha, Rodrigo A.; Sebastião, Ana M.; Boison, Detlev, Journal of Caffeine and Adenosine Research. 45 - 60. 2. 10. 2020. http://dx.doi.org/10.1089/caff.2019.0022 . 10.1089/caff.2019.0022 . Journal of Caffeine and Adenosine Research

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, F.Q.; Lopes, J.P.; Silva, H.B.; Lemos, C.; Silva, A.C.; Gonçalves, N.; Tomé, Â.R.; et al, Neurobiology of Disease. 132. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070868674&partnerID=MN8TOARS . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease

Carmo, M.; Gonçalves, F.Q.; Canas, P.M.; Oses, J.-P.; Fernandes, F.D.; Duarte, F.V.; Palmeira, C.M.; et al, British Journal of Pharmacology. 3666 - 3680. 18. 176. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070072977&partnerID=MN8TOARS . 10.1111/bph.14771 . British Journal of Pharmacology

Validation of an LC-MS/MS Method for the quantification of caffeine and theobromine using non-matched matrix calibration curve

Mendes, V.M.; Coelho, M.; Tomé, A.R.; Cunha, R.A.; Manadas, B., Molecules. 16. 24. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070695102&partnerID=MN8TOARS . 10.3390/molecules24162863 . Molecules

Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages

Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro, Pulmonary Pharmacology & Therapeutics. 90 - 94. 45. 2017. https://doi.org/10.1016/j.pupt.2017.04.009 . 10.1016/j.pupt.2017.04.009 . Pulmonary Pharmacology & Therapeutics

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

Boia, R.; Elvas, F.; Madeira, M.H.; Aires, I.D.; Rodrigues-Neves, A.C.; Tralhão, P.; Szabó, E.C.; et al, Cell Death and Disease. 10. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041823993&partnerID=MN8TOARS . 10.1038/cddis.2017.451 . Cell Death and Disease

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease

Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A., Journal of Alzheimer's Disease. 525 - 536. 2. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Machado, N.J.; Simões, A.P.; Silva, H.B.; Ardais, A.P.; Kaster, M.P.; Garção, P.; Rodrigues, D.I.; et al, Molecular Neurobiology. 1552 - 1563. 2. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957698500&partnerID=MN8TOARS . 10.1007/s12035-016-9774-9 . Molecular Neurobiology

The effects of different concentrations of the alpha2-adrenoceptor agonist medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice

Ribeiro, P.O.; Antunes, L.M.; Nunes, C.S.; Silva, H.B.; Cunha, R.A.; Tomé, Â.R., Anesthesia and Analgesia. 1130 - 1137. 5. 120. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937967119&partnerID=MN8TOARS . 10.1213/ANE.0000000000000636 . Anesthesia and Analgesia

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Li, P.; Rial, D.; Canas, P.M.; Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS . 10.1038/mp.2014.182 . Molecular Psychiatry

Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models

Li, W.; Silva, H.B.; Real, J.; Wang, Y.-M.; Rial, D.; Li, P.; Payen, M.-P.; et al, Neurobiology of Disease. 70 - 80. 79. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929459097&partnerID=MN8TOARS . 10.1016/j.nbd.2015.03.030 . Neurobiology of Disease

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

Kaster, M.P.; Machado, N.J.; Silva, H.B.; Nunes, A.; Ardais, A.P.; Santana, M.; Baqi, Y.; et al, Proceedings of the National Academy of Sciences of the United States of America. 7833 - 7838. 25. 112. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934894606&partnerID=MN8TOARS . 10.1073/pnas.1423088112 . Proceedings of the National Academy of Sciences of the United States of America

ATP as a multi-target danger signal in the brain

Rodrigues, R.J.; Tomé, A.R.; Cunha, R.A., Frontiers in Neuroscience. APR. 9. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS . 10.3389/fnins.2015.00148 . Frontiers in Neuroscience

Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Gon¿alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al, British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS . 10.1111/bph.12970 . British Journal of Pharmacology

Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia

Ribeiro, P.O.; Silva, H.B.; Tomé, Â.R.; Cunha, R.A.; Antunes, L.M., Lab Animal. 353 - 357. 10. 43. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964301385&partnerID=MN8TOARS . 10.1038/laban.571 . Lab Animal

Behavioral phenotyping of Parkin-deficient mice: Looking for early preclinical features of Parkinson's disease

Rial, D.; Castro, A.A.; Machado, N.; Garc¸ão, P.; Gonc¸alves, F.Q.; Silva, H.B.; Tomé, Â.R.; et al, PLoS ONE. 12. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84915758165&partnerID=MN8TOARS . 10.1371/journal.pone.0114216 . PLoS ONE

Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices

Ribeiro, P.O.; Tomé, Â.R.; Silva, H.B.; Cunha, R.A.; Antunes, L.M., Brain Research. 10 - 17. 1560. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898450346&partnerID=MN8TOARS . 10.1016/j.brainres.2014.03.004 . Brain Research

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Guendalina, Paula; Tomé, Angelo R.; Chen, Jiayang; Pittaluga, Anna; et al, Neuropharmacology. 488 - 497. 79. 2014. http://hdl.handle.net/10316/27138 . 10.1016/j.neuropharm.2013.12.014 . Neuropharmacology

Nicotinic a7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens

Zappettini, S.; Grilli, M.; Olivero, G.; Chen, J.; Padolecchia, C.; Pittaluga, A.; Tomé, A.R.; Cunha, R.A.; Marchi, M., Frontiers in Cellular Neuroscience. OCT. 8. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908006452&partnerID=MN8TOARS . 10.3389/fncel.2014.00332 . Frontiers in Cellular Neuroscience

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

Silva, C.G.; Métin, C.; Fazeli, W.; Machado, N.J.; Darmopil, S.; Launay, P.-S.; Ghestem, A.; et al, Science Translational Medicine. 197. 5. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883887587&partnerID=MN8TOARS . 10.1126/scitranslmed.3006258 . Science Translational Medicine

Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum

Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology

Blockade of adenosine A2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A., Journal of Neuroinflammation. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS . 10.1186/1742-2094-9-204 . Journal of Neuroinflammation

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A., Journal of Neurochemistry. 100 - 111. 1. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07178.x . Journal of Neurochemistry

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A., Biochimica et Biophysica Acta - Biomembranes. 1380 - 1399. 5. 1808. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS . 10.1016/j.bbamem.2010.12.001 . Biochimica et Biophysica Acta - Biomembranes

Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels

Rosário, Luís M.; Barbosa, Rui M.; Antunes, Célia M.; Baldeiras, Inês E.; Silva, Amélia M.; Tomé, Ângelo R.; Santos, Rosa M.; et al, Endocrine Journal. 639 - 650. 4. 55. 2008. http://hdl.handle.net/10316/12613 . 10.1507/endocrj.K07E-131 . Endocrine Journal

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells

Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., Pancreas. 279 - 283. 3. 36. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS . 10.1097/MPA.0b013e31815a8473 . Pancreas

Functional distribution of Ca2+-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells

Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.; Tomé, A.R.; Castro, E.; Santos, R.M.; Rosário, L.M., BMC Neuroscience. 8. 2007. http://hdl.handle.net/10316/12648 . 10.1186/1471-2202-8-39 . BMC Neuroscience

Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP

Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.; Tomé, A.R.; Castro, E.; Santos, R.M.; Rosário, L.M., BMC Neuroscience. 8. 2007. http://hdl.handle.net/10316/12647 . 10.1186/1471-2202-8-41 . BMC Neuroscience

Effects of Li+ transport and intracellular binding on Li+/Mg2+ competition in bovine chromaffin cells

Fonseca, C. P.; Montezinho, L. P.; Nabais, C.; Tomé, A. R.; Freitas, H.; Geraldes, C. F. G. C.; Castro, M. M. C. A.; et al, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 79 - 90. 2-3. 1691. 2004. http://hdl.handle.net/10316/3866 . 10.1016/j.bbamcr.2003.12.005 . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells

Tomé, Angelo R.; Izaguirre, Victor; Rosário, Luís M.; Ceña, Valentín; González-García, Carmen; Tomé, A.R.; Izaguirre, V.; et al, Brain Research. 62 - 65. 1-2. 903. 2001. http://hdl.handle.net/10316/3886 . 10.1016/S0006-8993(01)02388-5 . Brain Research

Glucose-mediated Ca2+ signalling in single clonal insulin-secreting cells: Evidence for a mixed model of cellular activation

Salgado, A.P.; Santos, R.M.; Fernandes, A.P.; Tomé, A.R.; Flatt, P.R.; Rosário, L.M.; Salgado, António P.; et al, International Journal of Biochemistry and Cell Biology. 557 - 569. 5. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034192385&partnerID=MN8TOARS . 10.1016/S1357-2725(99)00146-6 . International Journal of Biochemistry and Cell Biology

Differential contribution of syntaxin 1 and SNAP-25 to secretion in noradrenergic and adrenergic chromaffin cells

Baltazar, G.; Tomé, A.; Carvalho, A.P.; Duarte, E.P., European Journal of Cell Biology. 883 - 891. 12. 79. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535360&partnerID=MN8TOARS . European Journal of Cell Biology

Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics

Barbosa, R.M.; Silva, A.M.; Tomé, A.R.; Stamford, J.A.; Santos, R.M.; Rosário, L.M.; Barbosa, Rui M.; et al, Journal of Physiology. 135 - 143. 1. 510. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032126361&partnerID=MN8TOARS . 10.1111/j.1469-7793.1998.135bz.x . Journal of Physiology

Morphological field emission-SEM study of the effect of six phosphoric acid etching agents on human dentin

Perdigão, J.; Lambrechts, P.; Van Meerbeek, B.; Tomé, Â.R.; Vanherle, G.; Lopes, A.B., Dental Materials. 262 - 271. 4. 12. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030178905&partnerID=MN8TOARS . 10.1016/S0109-5641(96)80033-9 . Dental Materials

Real time electrochemical detection of 5-HT/insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization

Barbosa, R.M.; Silva, A.M.; Tomé, A.R.; Stamford, J.A.; Santos, R.M.; Rosário, L.M., Biochemical and Biophysical Research Communications. 100 - 104. 1. 228. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030297323&partnerID=MN8TOARS . 10.1006/bbrc.1996.1622 . Biochemical and Biophysical Research Communications

Protein kinase C activator inhibits voltage-sensitive Ca2+ channels and catecholamine secretion in adrenal chromaffin cells

Sena, C.M.; Tomé, A.R.; Santos, R.M.; Rosário, L.M., FEBS Letters. 137 - 141. 2-3. 359. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028816891&partnerID=MN8TOARS . 10.1016/0014-5793(95)00026-6 . FEBS Letters

Cell-specific purinergic receptors coupled to Ca2+ entry and Ca2+ release from internal stores in adrenal chromaffin cells: Differential sensitivity to UTP and Suramin

Castro, E.; Mateo, J.; Tomé, A.R.; Barbosa, R.M.; Miras-Portugal, M.T.; Rosário, L.M., Journal of Biological Chemistry. 5098 - 5106. 10. 270. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912175&partnerID=MN8TOARS . 10.1074/jbc.270.10.5098 . Journal of Biological Chemistry

Single-cell fura-2 microfluorometry reveals different purinoceptor subtypes coupled to Ca2+ influx and intracellular Ca2+ release in bovine adrenal chromaffin and endothelial cells

Castro, E.; Tomé, A.R.; Miras-Portugal, M.T.; Rosário, L.M., Pflügers Archiv European Journal of Physiology. 524 - 533. 6. 426. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028219206&partnerID=MN8TOARS . 10.1007/BF00378530 . Pflügers Archiv European Journal of Physiology

Neomycin blocks dihydropyridine-insensitive Ca2+ influx in bovine adrenal chromaffin cells

Duarte, C.B.; Tome, A.R.; Forsberg, E.; Carvalho, C.A.M.; Carvalho, A.P.; Santos, R.M.; Rosario, L.M., European Journal of Pharmacology: Molecular Pharmacology. 259 - 267. 3. 244. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027536487&partnerID=MN8TOARS . 10.1016/0922-4106(93)90151-X . European Journal of Pharmacology: Molecular Pharmacology

Physical basis for the resolution of intra- and extracellular cesium-133 NMR resonances in cesium(+) loaded human erythrocyte suspensions in the presence and absence of shift reagents

Wittenkeller, L.; dc Freitas, D.M.; Geraldes, C.F.G.C.; Tomé, A.J.R.; Wittenkeller, Lisa; Freitas, Duarte Mota de; Geraldes, Carlos F. G. C.; Tomé, Angelo J. R., Inorganic Chemistry. 1135 - 1144. 7. 31. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000752085&partnerID=MN8TOARS . 10.1021/ic00033a005 . Inorganic Chemistry

We use cookies to improve your visit to our website.