Célia Aveleira

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Researcher

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Cellular senescence mechanisms in the context of current biomarkers and senotherapies

Vasco Lucas; Claudia Cavadas; Aveleira C, Aging Research Reviews. 2021. under revision Aging Research Reviews

PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.

Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), Aging. 2021. accepted Aging

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky D J; Abdel-Aziz A K; ...; Aveleira C; Chun-Kit Tong, Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . published Autophagy

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A

Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation

Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . published Mediators of Inflammation

The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing

Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . published Nature Reviews Endocrinology

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation

Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, Cláudia, Aging. 1470 - 1484. 7. 8. 2016. http://dx.doi.org/10.18632/aging.100996 . 10.18632/aging.100996 . published Aging

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, Magda M.; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico C.; Kaster, Manuella P.; Aveleira, Célia A.; Ferreira, Marisa; Álvaro, Ana Rita; Cavadas, Cláudia, European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://dx.doi.org/10.1016/j.euroneuro.2015.06.013 . 10.1016/j.euroneuro.2015.06.013 . published European Neuropsychopharmacology

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . Autophagy

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells

Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . published Neuroscience Letters

Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress

Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, Neuroscience. 1 - 11. 273. 2014. http://dx.doi.org/10.1016/j.neuroscience.2014.04.042 . 10.1016/j.neuroscience.2014.04.042 . published Neuroscience

Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro

Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE

Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . published Investigative Opthalmology & Visual Science

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease

Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís, Brain. 2173 - 2188. 7. 136. 2013. http://dx.doi.org/10.1093/brain/awt144 . 10.1093/brain/awt144 . published Brain

Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity

Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . published PLoS ONE

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, PLoS ONE. 5. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0019745 . 10.1371/journal.pone.0019745 . published PLoS ONE

High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . published Cytokine

TNF-  Signals Through PKCz /NF- kB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . published Diabetes

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . published Experimental Eye Research

Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . published Ocular Immunology and Inflammation

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2020/01 - 2023/12

CIBB (Center for Innovative Biotecnology and Biomedicine) - Institutional Strategic Project

UIDB/04539/2020

Researcher

Fundação para a Ciência e a Tecnologia

2018/06 - 2021/05

NiNjA - New Neuroendocrine Strategy for healthy Aging (Co-Principal Investigator)

POCI-01-0145-FEDER-030167

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07/06 - 2021/07/05

Ostructive Sleep Apnea early diagnosis as a new strategy to delay ageing

PTDC/MEC-MCI/29002/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/01 - 2020/12

HEALTHY AGING 2020

CENTRO-01-0145-FEDER-000012

Researcher

Universidade de Coimbra

Funders: Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)

2017/01/01 - 2021/12/31

Ghrelin: a new therapeutic strategy to delay aging through hypothalamic control

IF/00825/2015

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/01/01 - 2016/12/31

Ghrelin: a new therapeutic strategy to delay aging through hypothalamic control

SFRH/BPD/111710/2015

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/06/01 - 2019/12/31

Imaging Gene Therapy in the Brain

PTDC/BBB-NAN/0932/2014

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015/01 - 2018/12

CNC.IBILI - Institutional strategic project

POCI-01-0145-FEDER-007440

Researcher

European Regional Development Fund

2015/04 - 2016/12

Ghrelin: a novel therapeutic intervention to rescue the phenotype of Hutchinson-Gilford Progeria Syndrome

PRF2014-53

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Progeria Research Foundation

2013/01 - 2014/12

Heatlh Sciences (Institutional strategic project)

PEst-C/SAU/LA0001/2013e2014

Researcher

Fundação para a Ciência e a Tecnologia

2013/10 - 2015/09

Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics

CENTRO-07-ST24-FEDER-002006

Invited Scientist Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: QREN - Mais Centro: Programa Operacional Regional do Centro 2007-2013

2011/01 - 2012/12

Heatlh Sciences (Institutional strategic project)

PEst-C/SAU/LA0001/2011

Researcher

Fundação para a Ciência e a Tecnologia

2011/04/01 - 2013/09/30

Neuropeptide Y as a caloric restriction mimetic: a new target for aging?

SFRH/BPD/73942/2010

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/04/01 - 2011/03/31

Caloric restriction increases lifespan: role of neuropeptide Y on autophagy

PTDC/SAU-FCF/099082/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/04/01 - 2013/09/30

Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation

info:eu-repo/grantAgreement/FCT/5876-PPCDTI/98685/PT

Researcher

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade do Algarve Faculdade de Ciências e Tecnologia

2007/05/01 - 2010/11/30

Neuropeptide Y in the retina: Why? What for?

PTDC/SAU-NEU/73119/2006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/06/01 - 2010/12/31

Regulation of AMPA receptors by hyperglycemia in the retina

PTDC/SAU-NEU/71228/2006

Researcher

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005/01 - 2005/12

Regulation of the expression of the type I IL-1 receptor in the retina

GAI 10/05

Researcher

Universidade de Coimbra Faculdade de Medicina; Institute of Biomedical Research in Light and Image (IBILI)

Funders: Faculdade de Medicina, Universidade de Coimbra

2005/02/01 - 2009/01/31

The role of interleukin-1 beta in blood-retinal barrier breakdown in the early stages of Diabetic Retinopathy

SFRH/BD/18727/2004

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina; Institute of Biomedical Research in Light and Image (IBILI)

Funders: Fundação para a Ciência e a Tecnologia

2002/02/01 - 2005/01/31

Mechanisms of cell degeneration in diabetic retinopathy

POCTI/CBO/38545/2001

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

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