Caio Haddad Franco

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PostDoc Researcher


Caio H. Franco completed a Ph.D. in Sciences (Major in Microbiology and Immunology) from Federal University of São Paulo in 2018. He has published 24 articles in peer-reviewed journals, accumulating more than 290 citations to date (accumulated impact factor 91.24, h-factor: 10, Plubons - June 2021). The main research developed by C. Franco is in the fields of Cell Biology, Microbiology and Parasitology. His main activities were focused on the design and establishment of numerous in vitro infection screening assays (chiefly based on high-content microscopy analysis), performing large-scale screenings with libraries of small molecules/natural products, and phenotypic and genetic characterization of drug-resistant parasites (T. cruzi, P. falciparum). C. Franco also established a screening to identify compounds that disrupt/inhibit biofilm formation by Gram-positive bacteria (Staphylococcus spp.). C. Franco is currently working with functional genomics screenings and bacterial infections as a Postdoc at the RNA & Infection laboratory (PI: Dr. Ana Eulalio) at the Center for Neurosciences and Cell Biology (CNC/CIBB, University of Coimbra). His current work is focused on identifying microRNAs that regulate S. aureus infection, while also implementing a functional screening assay to assess the effects of microRNAs in Salmonella infection of macrophages.


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Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)

Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphaël; Barbosa, Euzébio Guimarães; Panciera, Michele; et al, Plants. 11. 10. 2021. . 10.3390/plants10112235 . published Plants

Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes

Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al, International Journal of Molecular Sciences. 10. 21. 2020. . 10.3390/ijms21103659 . published International Journal of Molecular Sciences

On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors

Bonatto, Vinicius; Batista, Pedro Henrique Jatai; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; et al, RSC Medicinal Chemistry. 1275 - 1284. 11. 11. 2020. . 10.1039/d0md00097c . published RSC Medicinal Chemistry

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al, International Journal for Parasitology: Drugs and Drug Resistance. 107 - 120. 13. 2020. . 10.1016/j.ijpddr.2020.06.001 . published International Journal for Parasitology: Drugs and Drug Resistance

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity

Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia, Planta Medica. 782 - 789. 11. 86. 2020. . 10.1055/a-1179-1003 . published Planta Medica

Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

Cleber C. Melo-Filho; Rodolpho C. Braga; Eugene N. Muratov; Caio Haddad Franco; Carolina B. Moraes; Lucio H. Freitas-Junior; Carolina Horta Andrade, European Journal of Medicinal Chemistry. 649 - 659. 163. 2019. 10.1016/j.ejmech.2018.11.062 . published European Journal of Medicinal Chemistry

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics

Borsari, Chiara; Dolores Jimenez-Anton, Maria; Eick, Julia; Bifeld, Eugenia; Jose Torrado, Juan; Isabel Olias-Molero, Ana; Jesus Corral, Maria; et al, European Journal of Medicinal Chemistry. 2019. 10.1016/J.EJMECH.2019.111676 . published European Journal of Medicinal Chemistry

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Caio Haddad Franco; Laura Maria Alcântara; Eric Chatelain; Lucio Freitas-Junior; Carolina Borsoi Moraes, Tropical Medicine and Infectious Disease. 82 - 82. 2. 4. 2019. 10.3390/tropicalmed4020082 . published Tropical Medicine and Infectious Disease

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al, Bioorganic & Medicinal Chemistry. 22. 27. 2019. . 10.1016/j.bmc.2019.115083 . published Bioorganic & Medicinal Chemistry

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Linciano, Pasquale; Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al, Journal of Medicinal Chemistry. 2019. 10.1021/ACS.JMEDCHEM.8B02021 . published Journal of Medicinal Chemistry

Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir

Rodrigues e Silva Tiago; Vaz dos Santos Neto Eugenio; Lucia Tasca Goiz Ruiz Ana; Ann Foglio Mary; Haddad Franco Caio; Borsoi Moraes Carolina; Maia de Oliveira Valéria, African Journal of Microbiology Research. 897 - 907. 37. 12. 2018. 10.5897/ajmr2018.8940 . published African Journal of Microbiology Research

Tetracycline@silver ions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration

Karim Bouchmella; Felipe Davi Campanaro; Gabriela Borba Mondo; Murilo Izidoro Santos; Caio Haddad Franco; Carolina Borsoi Moraes; Christine Biolley; Ahmad Mehdi; Mateus Borba Cardoso, Nanomedicine. 14. 13. 2018. 10.2217/nnm-2018-0027 . published Nanomedicine

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

Fabricio Castro Machado; Caio Haddad Franco; Jose Vitorino dos Santos Neto; Karina Luiza Dias-Teixeira; Carolina Borsoi Moraes; Ulisses Gazos Lopes; Bertal Huseyin Aktas; Sergio Schenkman, Scientific Reports. 1. 8. 2018. 10.1038/s41598-018-23259-9 . published Scientific Reports

Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities

Tiago R. Silva; Alysson W. F. Duarte; Michel R. Z. Passarini; Ana Lucia T. G. Ruiz; Caio Haddad Franco; Carolina Borsoi Moraes; Itamar Soares de Melo; et al, Polar Biology. 1505 - 1519. 7. 41. 2018. 10.1007/s00300-018-2300-y . published Polar Biology

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. 10.1016/j.ejmech.2018.01.043 . published European Journal of Medicinal Chemistry

Investigating the structure-activity relationships of N’-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds

Palace-Berl, F.; Pasqualoto, K.F.M.; Zingales, B.; Moraes, C.B.; Bury, M.; Franco, C.H.; da Silva Neto, A.L.; et al, European Journal of Medicinal Chemistry. 29 - 40. 144. 2018. 10.1016/j.ejmech.2017.12.011 . published European Journal of Medicinal Chemistry

A comparative study of warheads for design of cysteine protease inhibitors

Daniel G. Silva; Jean F.R. Ribeiro; Daniela De Vita; Lorenzo Cianni; Caio Haddad Franco; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; et al, Bioorganic & Medicinal Chemistry Letters. 5031 - 5035. 22. 27. 2017. 10.1016/j.bmcl.2017.10.002 . published Bioorganic & Medicinal Chemistry Letters

Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols

Balfour, M.N.; Franco, C.H.; Moraes, C.B.; Freitas-Junior, L.H.; Stefani, H.A., European Journal of Medicinal Chemistry. 202 - 212. 128. 2017. 10.1016/j.ejmech.2017.01.040 . published European Journal of Medicinal Chemistry

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

Chiara Borsari; Nuno Santarem; Juan Torrado; Ana Isabel Olías; María Jesús Corral; Catarina Baptista; Sheraz Gul; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. 10.1016/j.ejmech.2016.12.017 . published European Journal of Medicinal Chemistry

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

Damien Bosc; Elisabeth Mouray; Sandrine Cojean; Caio Haddad Franco; Philippe M. Loiseau; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; Philippe Grellier; Joëlle Dubois, European Journal of Medicinal Chemistry. 173 - 186. 109. 2016. 10.1016/j.ejmech.2015.12.045 . published European Journal of Medicinal Chemistry

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

Silva, F.T.; Franco, C.H.; Favaro, D.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ferreira, E.I., European Journal of Medicinal Chemistry. 553 - 560. 121. 2016. 10.1016/j.ejmech.2016.04.065 . published European Journal of Medicinal Chemistry

Novel drug discovery for Chagas disease

Carolina B. Moraes; Caio H. Franco, Expert Opinion on Drug Discovery. 447 - 455. 5. 11. 2016. 10.1517/17460441.2016.1160883 . published Expert Opinion on Drug Discovery

Mutagenic potential of lettuce grown from irradiated seeds

Caio Haddad Franco; Valter H.M. dos Santos; Luciana P. Silva; Valter Arthur; Regildo M.G. Silva, Scientia Horticulturae. 27 - 30. 182. 2015. 10.1016/j.scienta.2014.11.011 . published Scientia Horticulturae

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development

Moraes, C.B.; Giardini, M.A.; Kim, H.; Franco, C.H.; Araujo-Junior, A.M.; Schenkman, S.; Chatelain, E.; Freitas-Junior, L.H., Scientific Reports. 1 - 11. 4. 2014. 10.1038/srep04703 . published Scientific Reports

Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites

Laura M. Alcantara; Junwon Kim; Carolina B. Moraes; Caio H. Franco; Kathrin D. Franzoi; Sukjun Lee; Lucio H. Freitas-Junior; Lawrence S. Ayong, Experimental Parasitology. 235 - 243. 2. 134. 2013. 10.1016/j.exppara.2013.03.022 . published Experimental Parasitology

All projects

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Information of exclusive responsibility of the researcher 26-06-2022 , from platform CIÊNCIAVITAE.

2022 - 2023/06/15

Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains


Principal investigator

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2019 -

Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains


Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2019

Development of an in vitro antibiofilm screening assay against strains of S. aureus and S. epidermidis


Post-doc Fellow

Universidade de São Paulo Instituto de Ciencias Biomédicas; Eurofarma Laboratórios

Funders: Fundação de Apoio a Universidade de São Paulo

2017 - 2019

Identification of starting points for drug discovery and target identification against major neglected diseases


PhD Student Fellow

Laboratório Nacional de Biociências; Centro Nacional de Pesquisa em Energia e Materiais; Universidade de São Paulo

Funders: Medicines for Malaria Venture

2014 - 2017

NMTrypl - New Drugs for Trypanosomatidic Infections


PhD Student Fellow

Laboratório Nacional de Biociências; Centro Nacional de Pesquisa em Energia e Materiais

Funders: European Commission Seventh Framework Programme for Research and Technological Development Regions of Knowledge

2014 - 2018

Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening


PhD Student Fellow

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico

2010 - 2013

Determination of generic doses of ionizing radiation for quarantine treatment


Scientific Initiation Fellow

Universidade de São Paulo Centro de Energia Nuclear na Agricultura

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