Carla Maria Nunes Lopes

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Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Exosomes: Innocent bystanders or critical culprits in neurodegenerative diseases

Beatriz, Margarida; Vilaça, Rita; Lopes, Carla, Frontiers in Cell and Developmental Biology. 2021. published Frontiers in Cell and Developmental Biology

Revisiting cell and gene therapies in Huntington's disease

Beatriz, Margarida; Lopes, Carla; Ribeiro, Ana Cláudia S.; Rego, Ana Cristina Carvalho, Journal of Neuroscience Research. 1744 - 1762. 7. 99. 2021. http://dx.doi.org/10.1002/jnr.24845 . 10.1002/jnr.24845 . Journal of Neuroscience Research

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models

Naia, Luana; Ly, Philip; Mota, Sandra I.; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al, Neurotherapeutics. 2021. http://dx.doi.org/10.1007/s13311-021-01022-9 . 10.1007/s13311-021-01022-9 . published Neurotherapeutics

Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics

Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al, Free Radical Biology and Medicine. 163 - 179. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031 . 10.1016/j.freeradbiomed.2020.11.031 . published Free Radical Biology and Medicine

Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers

Lopes, Carla; Castelhano, Joao; Margarida Fernandes Beatriz (431D-E8EB-DA99); Carolina Fernandes; Mário Laço; Cristina Januário; Abrunhosa, Antero J; Castelo-Branco, Miguel; Ana Cristina Carvalho Rego, European Journal of Clinical Investigation. S1. 50. 2020. http://dx.doi.org/10.1111/eci.13369 . 10.1111/eci.13369 . European Journal of Clinical Investigation

Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics

Beatriz, Margarida; Rita Pereira Vilaça (B317-85CF-B04B); Thorsten Michael Schlaeger; Daley, George Q.; Ana Cristina Carvalho Rego; Lopes, Carla, European Journal of Clinical Investigation. S1. 50. 2020. http://dx.doi.org/10.1111/eci.13369 . 10.1111/eci.13369 . European Journal of Clinical Investigation

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Lopes, Carla; Tang, Yang; Anjo, Sandra I.; Manadas, Bruno; Onofre, Isabel; de Almeida, Luís P.; Daley, George Q.; Schlaeger, Thorsten M.; Rego, Ana Cristina Carvalho, Frontiers in Cell and Developmental Biology. 8. 2020. http://dx.doi.org/10.3389/fcell.2020.576592 . 10.3389/fcell.2020.576592 . published Frontiers in Cell and Developmental Biology

SIRT 3 , a modifier of mitochondrial function in Huntington's disease

Naia, Luana; Carmo, Catarina; Campesan, Susanna; Lopes, Carla; Valero, Jorge; Rosenstock, Tatiana R.; Giorgini, Flaviano; Cristina Rego, A., Free Radical Biology and Medicine. 120. 2018. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.072 . 10.1016/j.freeradbiomed.2018.04.072 . published Free Radical Biology and Medicine

Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant

Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al, Neuromuscular Disorders. 350 - 360. 4. 28. 2018. http://dx.doi.org/10.1016/j.nmd.2017.11.006 . 10.1016/j.nmd.2017.11.006 . published Neuromuscular Disorders

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Barnat, Monia; Rego, Ana Cristina; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Blum, David, PLOS ONE. e0148680 - e0148680. 2. 11. 2016. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148680 . 10.1371/journal.pone.0148680 . published PLOS ONE

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin

Naia, Luana; Ribeiro, Márcio; Rodrigues, Joana; Duarte, Ana I.; Lopes, Carla; Rosenstock, Tatiana R.; Hayden, Michael R.; Rego, A. Cristina, Neuropeptides. 73 - 81. 58. 2016. http://dx.doi.org/10.1016/j.npep.2016.01.009 . 10.1016/j.npep.2016.01.009 . published Neuropeptides

Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?

Lopes, Carla; Rego, A. Cristina, Molecular Neurobiology. 1858 - 1873. 3. 54. 2016. http://dx.doi.org/10.1007/s12035-016-9714-8 . 10.1007/s12035-016-9714-8 . published Molecular Neurobiology

IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina, Molecular Neurobiology. 1126 - 1142. 3. 49. 2013. 10.1007/s12035-013-8585-5 . published Molecular Neurobiology

Peripheral and cerebral metabolic features in an animal model of Huntington's disease

Lopes, Carla Maria Nunes; Duarte, Ana I.; Hayden, Michael; Ana Cristina Carvalho Rego, IEEE Xplore Digital Library. 1 - 5. ,. 2012. http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6331390&isnumber=6331337 . 10.1109/ENBENG.2012.6331390 . published IEEE Xplore Digital Library

All projects

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2018/07/05 - 2021/07/04

iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics

POCI-01-0145-FEDER-029621

Principal investigator

Centro de Neurociencias e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07/05 - 2021/07/04

iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics

POCI-01-0145-FEDER-029621

Principal investigator

Centro de Neurociencias e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015 - 2017

Exploring the role of pridopidine on mitochondrial function and dynamics in Huntington's disease models

TEVA Pharmaceutical Industries

Post-doc

Centro de Neurociencias e Biologia Celular

Funders: Teva Pharmaceutical Industries Ltd

2015/12/01 - 2017/11/30

Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells

FLAD LIFE SCIENCE 2020

Post-doc Fellow

Centro de Neurociencias e Biologia Celular

Funders: Fundação Luso-Americana

2010/11/01 - 2014/10/31

Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease

SFRH / BD / 51192 / 2010

PhD Student Fellow

Centro de Neurociencias e Biologia Celular; Universidade de Coimbra Instituto de Investigação Interdisciplinar

Funders: Fundação para a Ciencia e Tecnologia

2007/10 - 2008/05

AGES (Advanced Glycation End Products) and vascular complications in type 2 diabetes

GAPI Medical School

Other

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

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