Carla Maria dos Santos Nunes

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Researcher

Publications

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Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease

Carla Nunes; João Laranjinha, Archives of Biochemistry and Biophysics. 108877 - 108877. 704. 2021. https://doi.org/10.1016/j.abb.2021.108877 . 10.1016/j.abb.2021.108877 . Archives of Biochemistry and Biophysics

The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M., Neurochemical Research. 64 - 76. 1. 46. 2021. http://dx.doi.org/10.1007/s11064-020-03015-0 . 10.1007/s11064-020-03015-0 . published Neurochemical Research

Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties

Couto, Joana; Figueirinha, Artur; Batista, Maria Teresa; Paranhos, António; Nunes, Carla; Gonçalves, Lídia Maria; Marto, Joana; et al, Antioxidants. 2. 9. 2020. http://dx.doi.org/10.3390/antiox9020154 . 10.3390/antiox9020154 . published Antioxidants

Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation

Carla Nunes; Víctor Freitas; Leonor Almeida; João Laranjinha, Food & Function. 2019. https://doi.org/10.1039/C8FO02469C . 10.1039/C8FO02469C . Food & Function

Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells

Nunes, Carla; Figueiredo, Rui; Laranjinha, João; da Silva, Gabriela Jorge, Chemico-Biological Interactions. 310. 2019. http://dx.doi.org/10.1016/j.cbi.2019.06.024 . 10.1016/j.cbi.2019.06.024 . published Chemico-Biological Interactions

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

Nunes, Carla; Almeida, Leonor; Barbosa, Rui M.; Laranjinha, João, Food & Function. 387 - 396. 1. 8. 2017. http://dx.doi.org/10.1039/c6fo01529h . 10.1039/c6fo01529h . published Food & Function

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways

Nunes, Carla; Teixeira, N.; Serra, D.; Freitas, V.; Almeida, L.; Laranjinha, João, Toxicology Research. 53 - 65. 1. 5. 2016. http://dx.doi.org/10.1039/c5tx00214a . 10.1039/c5tx00214a . published Toxicology Research

Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome

Nunes, Carla; Rocha, Bárbara S.; Laranjinha, João, The International Journal of Biochemistry & Cell Biology. 393 - 402. 81. 2016. http://dx.doi.org/10.1016/j.biocel.2016.10.021 . 10.1016/j.biocel.2016.10.021 . published The International Journal of Biochemistry & Cell Biology

Virulence Characterization of Salmonella enterica by a New Microarray: Detection and Evaluation of the Cytolethal Distending Toxin Gene Activity in the Unusual Host S. Typhimurium

Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge, PLOS ONE. 8. 10. 2015. http://dx.doi.org/10.1371/journal.pone.0135010 . 10.1371/journal.pone.0135010 . published PLOS ONE

A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate–nitrite–nitric oxide pathway in the gut

Rocha, Bárbara S.; Nunes, Carla; Pereira, Cassilda; Barbosa, Rui M.; Laranjinha, João, Food Funct.. 1646 - 1652. 8. 5. 2014. http://dx.doi.org/10.1039/c4fo00124a . 10.1039/c4fo00124a . published Food Funct.

Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells

Silva, Ana; Nunes, Carla; Martins, João; Dinis, Teresa C.P.; Lopes, Celeste; Neves, Bruno; Cruz, Teresa, Free Radical Biology and Medicine. 238 - 246. 72. 2014. http://dx.doi.org/10.1016/j.freeradbiomed.2014.04.005 . 10.1016/j.freeradbiomed.2014.04.005 . published Free Radical Biology and Medicine

Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells

Nunes, Carla; Ferreira, Elisabete; Freitas, Víctor; Almeida, Leonor; Barbosa, Rui M.; Laranjinha, João, Food Funct.. 373 - 383. 3. 4. 2013. http://dx.doi.org/10.1039/c2fo30233k . 10.1039/c2fo30233k . published Food Funct.

Human colon adenocarcinoma HT-29 cell: Electrochemistry and nicotine stimulation

Oliveira, Carlos; Santarino, Inês; Enache, Teodore; Nunes, Carla; Laranjinha, João; Barbosa, R.M.; Oliveira-Brett, Ana Maria, Bioelectrochemistry. 30 - 38. 94. 2013. http://dx.doi.org/10.1016/j.bioelechem.2013.05.004 . 10.1016/j.bioelechem.2013.05.004 . published Bioelectrochemistry

Cyanidin-3-Glucoside Suppresses Cytokine-Induced Inflammatory Response in Human Intestinal Cells: Comparison with 5-Aminosalicylic Acid

Serra, Diana; Paixão, Joana; Nunes, Carla; Dinis, Teresa C. P.; Almeida, Leonor M., PLoS ONE. 9. 8. 2013. http://dx.doi.org/10.1371/journal.pone.0073001 . 10.1371/journal.pone.0073001 . published PLoS ONE

Nitric oxide and DOPAC-induced cell death: From GSH depletion to mitochondrial energy crisis

Nunes, Carla; Barbosa, Rui M.; Almeida, Leonor; Laranjinha, João, Molecular and Cellular Neuroscience. 94 - 103. 1. 48. 2011. http://dx.doi.org/10.1016/j.mcn.2011.06.009 . 10.1016/j.mcn.2011.06.009 . published Molecular and Cellular Neuroscience

3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning

Nunes, Carla; Almeida, Leonor; Laranjinha, João, NeuroToxicology. 998 - 1007. 6. 29. 2008. http://dx.doi.org/10.1016/j.neuro.2008.07.003 . 10.1016/j.neuro.2008.07.003 . published NeuroToxicology

Redox interactions of nitric oxide with dopamine and its derivatives

Antunes, Fernando; Nunes, Carla; Laranjinha, João; Cadenas, Enrique, Toxicology. 207 - 212. 2. 208. 2005. http://dx.doi.org/10.1016/j.tox.2004.11.033 . 10.1016/j.tox.2004.11.033 . published Toxicology

Scavenging of nitric oxide by an antagonist of adenosine receptors

Sousa, Teresa; Fernandes, Eduarda; Nunes, Carla; Laranjinha, João; Carvalho, Félix; Pinho, Dora; Morato, Manuela; Albino-Teixeira, António, Journal of Pharmacy and Pharmacology. 399 - 404. 3. 57. 2005. http://dx.doi.org/10.1211/0022357055614 . 10.1211/0022357055614 . published Journal of Pharmacy and Pharmacology

Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC)Implications for Parkinson's disease

Nunes, Carla; Almeida, Leonor M.; Laranjinha, João, Neurochemistry International. 173 - 182. 3. 47. 2005. http://dx.doi.org/10.1016/j.neuint.2005.03.005 . 10.1016/j.neuint.2005.03.005 . published Neurochemistry International

All projects

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Information of exclusive responsibility of the researcher 26-06-2022 , from platform CIÊNCIAVITAE.

2021/09/22 -

Monitoring neurometabolic markers in vivo using microelectrode-based biosensors

POCI-01-0145-FEDER-028261

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019/12/11 - 2021/03/31

Healthy Aging 2020

Centro 2020 000012 Healthy Aging 2020

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2018/07/26 - 2021/07/25

Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet

PTDC/MED-NEU/29099/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Centro Hospitalar e Universitário de Coimbra EPE

Funders: Fundação para a Ciência e a Tecnologia

2013/04 - 2015/08/31

Red wine polyphenols as novel antimicrobial agents: molecular mechanisms involved in the protection against pathogenic intestinal bacteria

SFRH/BPD/46149/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2013/04 - 2015/08/31

Red wine polyphenols as novel antimicrobial agents: molecular mechanisms involved in the protection against pathogenic intestinal bacteria

SFRH/BPD/46149/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2012/04/01 - 2015/03/31

Nitric Oxide in Alzheimer´s Disease - Signaling Molecule and Mediator of Pathogenesis

PTDC/BIA-BCM/116576/2010

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/03/01 - 2014/12/31

Dietary Nitrate:Nitrite:Nitric oxide as a key pathway in gastrointestinal and cardiovascular physiology: uncovering new health properties of red wine and olive oil

PTDC/AGR-ALI/115744/2009

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2010/05/01 - 2013/10/31

Role of dietary polyphenols on intestinal inflammation either as single agents or in combination with anti-inflammatory drugs by using in vitro and in vivo models

PTDC/SAU-OSM/102907/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2010/06/01 - 2013/06/30

In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging

PTDC/SAU-NEU/103538/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2002/07 - 2006/10

Cell death with implications for Parkinson's disease involving nitric oxide and dopamine metabolism

SFRH/BD/5428/2001

PhD Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2001/07 - 2002/06

Oxidative damage of brain mitochondria induced by nitric oxide and dopamine

SFRH/BM/2464/2000

Master Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2001 - 2003

Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration.

POCTI/BCI/42365/2001

Research Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

1999 - 2001

Mitochondrial dysfunction induced by nitric oxide and dopamine in neuronal degeneration

PRAXIS/C/BIA/13195/98

Scientific Initiation Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

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