Filipa Baptista

Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy.

Realinho AM; Boia R; Paiva B; Correia RG; Gaspar R; Ambrósio AF; Baptista FI, Life sciences. 2023. http://europepmc.org/abstract/med/37321535 . 10.1016/j.lfs.2023.121852 . Life sciences

Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes

Andreia Marreiros Amaro; Diana Sousa; Mariana Sá-Rocha; Marcos Divino Ferreira-Junior; Daniela Rosendo-Silva; Lucas Paulo Jacinto Saavedra; Cátia Barra; et al, Nutrients. 2023. https://www.mdpi.com/2072-6643/15/16/3581 . 10.3390/nu15163581 . Nutrients

Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes

Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos D.; Barra, Cátia; Monteiro, Tamaeh; Mathias, Paulo; et al, Life Sciences. 321. 2023. http://dx.doi.org/10.1016/j.lfs.2023.121597 . 10.1016/j.lfs.2023.121597 . Life Sciences

Neonatal testosterone voids sexually differentiated microglia morphology and behavior.

Simões-Henriques CF; Rodrigues-Neves AC; Sousa FJ; Gaspar R; Almeida I; Baptista FI; Ambrósio AF; Gomes CA, Frontiers in endocrinology. 2023. https://europepmc.org/articles/PMC10013065 . 10.3389/fendo.2023.1102068 . Frontiers in endocrinology

Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders

Amaro, Andreia; Baptista, Filipa I.; Matafome, Paulo, Life Sciences. 298. 2022. http://dx.doi.org/10.1016/j.lfs.2022.120526 . 10.1016/j.lfs.2022.120526 . Life Sciences

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António F.; Rodrigues, Ana João; Gomes, Catarina A., Frontiers in Behavioral Neuroscience. 16. 2022. http://dx.doi.org/10.3389/fnbeh.2022.834821 . 10.3389/fnbeh.2022.834821 . Frontiers in Behavioral Neuroscience

Sex-specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress

Ana Sofia Ferreira; Sofia Galvão; Rita Gaspar; Ana C. Rodrigues-Neves; António F. Ambrósio; Paulo Matafome; Catarina A. Gomes; Filipa I. Baptista, European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13639 . 10.1111/eci.13639 . European Journal of Clinical Investigation

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Rodrigues-Neves AC; Carecho R; Correia SC; Carvalho C; Campos EJ; Baptista FI; Moreira PI; Ambrósio AF, Molecular neurobiology. 2021. http://europepmc.org/abstract/med/33606195 . 10.1007/s12035-021-02316-x . Molecular neurobiology

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Rita Gaspar; Carina Soares-Cunha; Ana Verónica Domingues; Bárbara Coimbra; Filipa I. Baptista; Luísa Pinto; António F. Ambrósio; Ana João Rodrigues; Catarina A. Gomes, Neurobiology of Stress. 100302 - 100302. 14. 2021. https://doi.org/10.1016/j.ynstr.2021.100302 . 10.1016/j.ynstr.2021.100302 . Neurobiology of Stress

Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 Diabetes.

Baptista, FI, Brain research bulletin. 2020. https://doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain research bulletin

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.

Baptista, FI, Cell reports. 2020. https://doi.org/10.1016/j.celrep.2020.107796 . 10.1016/j.celrep.2020.107796 . Cell reports

Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: putative targets for insulin therapy

Sousa, Fábio J.; Correia, Raquel G.; Cruz, Alexandra F.; Martins, Joana M.; Rodrigues, Matilde S.; Gomes, Catarina A.; Ambrósio, António F.; Baptista, Filipa I., Brain, Behavior, & Immunity - Health. 2020. http://dx.doi.org/10.1016/j.bbih.2020.100075 . 10.1016/j.bbih.2020.100075 . accepted Brain, Behavior, & Immunity - Health

Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: brain region and sex specificities.

Baptista, FI, The European journal of neuroscience. 2019. https://doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . The European journal of neuroscience

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel.

Chiquita S; Rodrigues-Neves AC; Baptista FI; Carecho R; Moreira PI; Castelo-Branco M; Ambrósio AF, Molecular neurobiology. 2019. http://europepmc.org/abstract/med/30612332 . 10.1007/s12035-018-1461-6 . Molecular neurobiology

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss.

Chiquita S; Ribeiro M; Castelhano J; Oliveira F; Sereno J; Batista M; Abrunhosa A; et al, Human molecular genetics. 2019. http://europepmc.org/abstract/med/30816415 . 10.1093/hmg/ddz045 . Human molecular genetics

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons.

Pinheiro H; Gaspar R; Baptista FI; Fontes-Ribeiro CA; Ambrósio AF; Gomes CA, Frontiers in pharmacology. 2018. http://europepmc.org/abstract/med/29615903 . 10.3389/fphar.2018.00219 . Frontiers in pharmacology

Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.

Alves MRP; Boia R; Campos EJ; Martins J; Nunes S; Madeira MH; Santiago AR; et al, Molecular vision. 2018. http://europepmc.org/abstract/med/29853770 . Molecular vision

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies.

Baptista FI; Pinheiro H; Gomes CA; Ambrósio AF, Molecular neurobiology. 2018. http://europepmc.org/abstract/med/30003516 . 10.1007/s12035-018-1227-1 . Molecular neurobiology

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study.

Ribeiro M; Castelhano J; Petrella LI; Sereno J; Rodrigues T; Neves C; Letra L; et al, Journal of magnetic resonance imaging : JMRI. 2018. http://europepmc.org/abstract/med/29377412 . 10.1002/jmri.25942 . Journal of magnetic resonance imaging : JMRI

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety.

Caetano L; Pinheiro H; Patrício P; Mateus-Pinheiro A; Alves ND; Coimbra B; Baptista FI; et al, 2016. http://europepmc.org/abstract/med/27725661 . 10.1038/mp.2016.173 .

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.

Baptista FI; Castilho ÁF; Gaspar JM; Liberal JT; Aveleira CA; Ambrósio AF, 2015. http://europepmc.org/abstract/med/26141610 . 10.1016/j.neulet.2015.06.044 .

Inside the diabetic brain: role of different players involved in cognitive decline.

Gaspar JM; Baptista FI; Macedo MP; Ambrosio AF, 2015. http://europepmc.org/abstract/med/26667832 .

Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina.

Castilho AF; Liberal JT; Baptista FI; Gaspar JM; Carvalho AL; Ambrósio AF, 2014. http://europepmc.org/abstract/med/24966661 .

Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.

Santiago AR; Baptista FI; Santos PF; Cristóvão G; Ambrósio AF; Cunha RA; Gomes CA, 2014. http://europepmc.org/abstract/med/25132733 . 10.1155/2014/465694 .

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.

Baptista FI; Pinto MJ; Elvas F; Martins T; Almeida RD; Ambrósio AF, 2014. http://europepmc.org/abstract/med/25064602 . 10.1016/j.exer.2014.07.011 .

Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer´s disease.

Baptista FI; Henriques AG; Silva AM; Wiltfang J; da Cruz E Silva OA, 2013. http://europepmc.org/abstract/med/24328060 .

Diabetes Alters KIF1A and KIF5B Motor Proteins in the Hippocampus

Baptista, F.I.; Pinto, M.J.; Elvas, F.; Almeida, R.D.; Ambrósio, A.F., PLoS ONE. 6. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878951512&partnerID=MN8TOARS . 10.1371/journal.pone.0065515 . PLoS ONE

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., Neuroscience. 23 - 32. 219. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity

Castilho, Á.F.; Aveleira, C.A.; Leal, E.C.; Simões, N.F.; Fernandes, C.R.; Meirinhos, R.I.; Baptista, F.I.; Ambrósio, A.F., PLoS ONE. 8. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864551111&partnerID=MN8TOARS . 10.1371/journal.pone.0042428 . PLoS ONE

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina

Baptista, F.I.; Gaspar, J.M.; Cristóvão, A.; Santos, P.F.; Köfalvi, A.; Ambrósio, A.F., Brain Research. 257 - 269. 1383. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952991975&partnerID=MN8TOARS . 10.1016/j.brainres.2011.01.071 . Brain Research

High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Aveleira, C.; Castilho, A.; Baptista, F.; Simões, N.; Fernandes, C.; Leal, E.; Ambrósio, A.F., Cytokine. 279 - 286. 3. 49. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75449089500&partnerID=MN8TOARS . 10.1016/j.cyto.2009.11.014 . Cytokine

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F., Neuroscience. 1589 - 1600. 4. 169. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955414626&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.06.021 . Neuroscience

Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons

Gaspar, J.M.; Castilho, Á.; Baptista, F.I.; Liberal, J.; Ambrósio, A.F., Neuroscience. 981 - 992. 4. 171. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650169655&partnerID=MN8TOARS . 10.1016/j.neuroscience.2010.10.019 . Neuroscience

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina

Santiago, A.R.; Gaspar, J.M.; Baptista, F.I.; Cristóvão, A.J.; Santos, P.F.; Kamphuis, W.; Ambrósio, A.F., Molecular Vision. 1620 - 1630. 15. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949158370&partnerID=MN8TOARS . Molecular Vision

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, E.C.; Aveleira, C.A.; Castilho, A.F.; Serra, A.M.; Baptista, F.I.; Hosoya, K.-I.; Forrester, J.V.; Ambrósio, A.F., Experimental Eye Research. 983 - 991. 5. 88. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64849101327&partnerID=MN8TOARS . 10.1016/j.exer.2008.12.010 . Experimental Eye Research

Müller cells do not influence leukocyte adhesion to retinal endothelial cells

Leal, E.C.; Aveleira, C.A.; Castilho, A.F.; Baptista, F.I.; Ambrósio, A.F., Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049095985&partnerID=MN8TOARS . 10.1080/09273940802204535 . Ocular Immunology and Inflammation

Is the quantity of orbicules released by Dactylis glomerata and Cynosurus echinatus (Poaceae) big enough to play an allergenic role?

Baptista, Filipa, Grana. 2007. http://www.tandfonline.com/doi/abs/10.1080/00173130701448066#.UooLosS-2M5 . 10.1080/00173130701448066 . Grana