Isabel Cristina do Vale Ferreira

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PhD Student


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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Allergic contact dermatitis: From pathophysiology to development of new preventive strategies

Brites, Gonçalo Sousa; Ferreira, Isabel; Sebastião, Ana Isabel; Silva, Ana; Carrascal, Mylene; Neves, Bruno Miguel; Cruz, Maria T., Pharmacological Research. 162. 2020. . 10.1016/j.phrs.2020.105282 . Pharmacological Research

NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify

Sebastião, Ana Isabel; Ferreira, Isabel; Brites, Gonçalo; Silva, Ana; Neves, Bruno Miguel; Teresa Cruz, Maria, Pharmaceutics. 9. 12. 2020. . 10.3390/pharmaceutics12090867 . Pharmaceutics

Evaluating Skin Sensitization Via Soft and Hard Multivariate Modeling

Silva, Filipa A. L. S.; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana; Miguel Neves, Bruno; Costa Pereira, Jorge L. G. F. S.; Cruz, Maria T., International Journal of Toxicology. 547 - 559. 6. 39. 2020. . 10.1177/1091581820944395 . International Journal of Toxicology

Apple Pomace Extract as a Sustainable Food Ingredient

Fernandes, Pedro A. R.; Ferreira, Sónia S.; Bastos, Rita; Ferreira, Isabel; Cruz, Maria T.; Pinto, António; Coelho, Elisabete; et al, Antioxidants. 6. 8. 2019. . 10.3390/antiox8060189 . Antioxidants

Chemical composition, anti-inflammatory activity and cytotoxicity of Thymus zygis L. subsp. sylvestris (Hoffmanns. & Link) Cout. essential oil and its main compounds

Rodrigues, Vanessa; Cabral, Célia; Évora, Leisa; Ferreira, Isabel; Cavaleiro, Carlos; Cruz, Maria Teresa; Salgueiro, Lígia, Arabian Journal of Chemistry. 3236 - 3243. 8. 12. 2019. . 10.1016/j.arabjc.2015.08.026 . Arabian Journal of Chemistry

Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1

Ferreira, Isabel; Silva, Ana; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa, Redox Biology. 75 - 86. 16. 2018. . 10.1016/j.redox.2018.02.002 . Redox Biology

New Insights into the Anti-Inflammatory and Antioxidant Properties of Nitrated Phospholipids

Melo, Tânia; Marques, Sara S.; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Pedro; Segundo, Marcela A.; Domingues, Maria Rosário Marques, Lipids. 117 - 131. 1. 53. 2018. . 10.1002/lipd.12007 . Lipids

Acanthus mollis L. leaves as source of anti-inflammatory and antioxidant phytoconstituents

Matos, Patrícia; Figueirinha, Artur; Ferreira, Isabel; Cruz, Maria Teresa; Batista, Maria Teresa, Natural Product Research. 1824 - 1827. 12. 33. 2018. . 10.1080/14786419.2018.1437438 . Natural Product Research

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

Santos, Sónia; Trindade, Stephanie; Oliveira, Catia; Parreira, Paula; Rosa, Daniela; Duarte, Maria; Ferreira, Isabel; et al, Marine Drugs. 11. 15. 2017. . 10.3390/md15110340 . Marine Drugs

Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

da Costa, Elisabete; Melo, Tânia; Moreira, Ana; Bernardo, Carina; Helguero, Luisa; Ferreira, Isabel; Cruz, Maria; et al, Marine Drugs. 3. 15. 2017. . 10.3390/md15030062 . Marine Drugs

Inflammasome in Dendritic Cells Immunobiology: Implications to Diseases and Therapeutic Strategies

Cruz, Maria Teresa; Ferreira, Isabel; Liberal, Joana; D Martins, Joao; Silva, Ana; Neves, Bruno Miguel, Current Drug Targets. 9. 18. 2017. . 10.2174/1389450117666160921144830 . Current Drug Targets

In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides

Martins, Vitor M.R.; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, M. Rosário; Coimbra, Manuel A., Carbohydrate Polymers. 176 - 184. 157. 2017. . 10.1016/j.carbpol.2016.09.079 . Carbohydrate Polymers

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Martins, J. D.; Silva, A.; Ferreira, I.; Gonçalo, M.; Custódio, J. B. A.; Lopes, M. C.; Domingues, M. R. M.; Neves, B. M.; Cruz, M. T., Toxicology Research. 1512 - 1521. 6. 5. 2016. . 10.1039/c6tx00240d . Toxicology Research

The Flavone Luteolin Inhibits Liver X Receptor Activation.

Francisco V; Figueirinha A; Costa G; Liberal J; Ferreira I; Lopes MC; García-Rodríguez C; Cruz MT; Batista MT, Journal of natural products. 2016. . 10.1021/acs.jnatprod.6b00146 . Journal of natural products

Phospholipidomic Profile Variation on THP-1 Cells Exposed to Skin or Respiratory Sensitizers and Respiratory Irritant.

Martins JD; Maciel EA; Silva A; Ferreira I; Ricardo F; Domingues P; Neves BM; Domingues MR; Cruz MT, Journal of cellular physiology. 2016. . 10.1002/jcp.25365 . Journal of cellular physiology

Autophagy and inflammasome interplay.

Martins JD; Liberal J; Silva A; Ferreira I; Neves BM; Cruz MT, DNA and cell biology. 2015. . 10.1089/dna.2014.2752 . DNA and cell biology

Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases.

Rufino AT; Ferreira I; Judas F; Salgueiro L; Lopes MC; Cavaleiro C; Mendes AF, Pharmaceutical biology. 2015. . 10.3109/13880209.2014.970701 . Pharmaceutical biology

Oxidative stress-dependent activation of the eIF2a–ATF4 unfolded protein response branch by skin sensitizer 1-fluoro-2,4-dinitrobenzene modulates dendritic-like cell maturation and inflammatory status in a biphasic manner [corrected].

Luís A; Martins JD; Silva A; Ferreira I; Cruz MT; Neves BM, Free radical biology & medicine. 2014. . 10.1016/j.freeradbiomed.2014.09.008 . Free radical biology & medicine

Anti-inflammatory effects of Thymus zygis subsp sylvestris essential oil in LPS-stimulated macrophages and microglia cells

Rodrigues, V; Cabral, C.; Evora, L.; Ferreira, I; Pereira, C.; Cavaleiro, C.; Cruz, M. T.; Salgueiro, L., Planta Medica. 2014. . Planta Medica

Essential oil of common sage (Salvia officinalis L.) from Jordan: assessment of safety in mammalian cells and its antifungal and anti-inflammatory potential.

Abu-Darwish MS; Cabral C; Ferreira IV; Gonçalves MJ; Cavaleiro C; Cruz MT; Al-bdour TH; Salgueiro L, BioMed research international. 2013. . 10.1155/2013/538940 . BioMed research international

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-¿B and MAPK activation in macrophages.

Búfalo MC; Ferreira I; Costa G; Francisco V; Liberal J; Cruz MT; Lopes MC; Batista MT; Sforcin JM, Journal of ethnopharmacology. 2013. . 10.1016/j.jep.2013.06.004 . Journal of ethnopharmacology

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2021/09 -

Development of a Defined Approach for Respiratory Sensitization Hazard Assessment


Principal investigator

Funders: Colgate Palmolive Co

2021 -

Dissecting the mechanism by which haptens disrupt lysosomes and activate NLRP3 inflammasome: the missing link in chemical allergic reactions physiopathology

EPIC-XS project 265


Funders: Horizon 2020 European Innovation Council Fast Track to Innovation

2020/06 -


CENTRO-01-0145- FEDER-000012

Research Fellow

Funders: European Regional Development Fund

2018/07/26 - 2021/07/25

Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease



Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016 -

Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer)


Funders: Cosmetics Europe

2014 - 2015

In chemico, in silico and in vitro dendritic cell modeling to predict human respiratory allergens


Research Fellow

Funders: Johns Hopkins University Center for Alternatives to Animal Testing

2012 - 2013

NutraCork: Phenolic compounds of cork: cosmetic validation, alimentary evaluation and nutraceutic potential

(Ref 21597)

Research Fellow

Funders: Projecto Estratégico Nacional (QREN)

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