João Pedro Oliveira da Silva Paulino Lopes

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Publications

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Information about journal articles, updated at 19-06-2022, from platform CIÊNCIAVITAE.

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure

Lopes, Cátia R.; Amaral, Inês M.; Pereira, Marlene F.; Lopes, João P.; Madeira, Daniela; Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula, Journal of Neurochemistry. 2022. http://dx.doi.org/10.1111/jnc.15575 . 10.1111/jnc.15575 . Journal of Neurochemistry

l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al, The FASEB Journal. 8. 35. 2021. http://dx.doi.org/10.1096/fj.202100336r . 10.1096/fj.202100336r . The FASEB Journal

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al, Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS . 10.1038/s41598-021-89964-0 . Scientific Reports

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.

Lopes, João, Neurobiology of disease. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of disease

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., Journal of Neurochemistry. 796 - 809. 6. 148. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS . 10.1111/jnc.14653 . Journal of Neurochemistry

What is the extracellular calcium concentration within brain synapses?

João Pedro Lopes; Rodrigo A. Cunha, Journal of Neurochemistry. 435 - 437. 4. 149. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al, Neurobiology of Disease. 72 - 81. 117. 2018. http://dx.doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P, 2016. http://europepmc.org/abstract/med/26497029 . 10.1007/s12035-015-9491-9 .

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system

Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al, Journal of Neurochemistry. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS . 10.1111/jnc.13109 . Journal of Neurochemistry

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A., PLoS ONE. 2. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS . 10.1371/journal.pone.0056870 . PLoS ONE

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity

Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A., Brain and Behavior. 67 - 74. 2. 3. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS . 10.1002/brb3.118 . Brain and Behavior

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J.P.; Agostinho, P., Progress in Neurobiology. 49 - 63. 1. 94. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.03.006 . Progress in Neurobiology

Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Aging Cell. 64 - 77. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS . 10.1111/j.1474-9726.2009.00536.x . Aging Cell

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology

Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS . 10.3233/JAD-2009-0993 . Journal of Alzheimer's Disease

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula, Cell Cycle. 97 - 104. 1. 8. 2009. http://dx.doi.org/10.4161/cc.8.1.7506 . 10.4161/cc.8.1.7506 . Cell Cycle

Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Current Alzheimer Research. 205 - 212. 3. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS . 10.2174/156720509788486590 . Current Alzheimer Research

Overactivation of calcineurin induced by amyloid-beta and prion proteins

Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R., Neurochemistry International. 1226 - 1233. 6. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS . 10.1016/j.neuint.2008.01.005 . Neurochemistry International

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cellular and Molecular Neurobiology. 943 - 957. 7. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS . 10.1007/s10571-007-9224-3 . Cellular and Molecular Neurobiology

Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente

Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A., Revista Portuguesa de Pneumologia. 5. 9. 2003. http://dx.doi.org/10.1016/s0873-2159(15)30711-x . 10.1016/s0873-2159(15)30711-x . Revista Portuguesa de Pneumologia

All projects

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Information of exclusive responsibility of the researcher 19-06-2022 , from platform CIÊNCIAVITAE.

2018/05/01 - 2020/06/06

Strategies for healthy aging

CENTRO-01-0246-FEDER-000010

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

2018/07/01 - 2021/06/30

Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer’s disease: mechanisms and therapeutic propects

PAS/31274

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2018 -

Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress

Fundacion LaCaixa

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia; Fundación La Caixa

2017 -

Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs

-

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2017 -

Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs

-

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2016/06/01 - 2018/05/31

Role of astrocytes in the control of memory – focus on adenosine A2A receptors

PTDC/NEU-NMC/4154/2014

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2016/10 - 2017/09

Adenosine A2A Receptor Antagonism Affords Integrated Benefits for Neurological Symptoms of Neurofibromatosis Type I

W81XWH-18-1-0532

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Congressionally Directed Medical Research Programs

2015/01/01 - 2017/06/30

The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer’s disease

Mantero-Bellard Award

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Santa Casa da Misericórdia de Lisboa

2012/05 - 2014/08

Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection

PTDC/SAU-TOX/122005/2010

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2011/08 - 2013/12

Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease

Provided by PTCRIS: 114810

Post-doc Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2008 -

Causas e consequências da reactivação do ciclo celular nos neurónios: implicações na doença de Alzheimer e nas encefalopatias por priões

GAPI 01/08

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2007 -

Neuroinflamação associada à doenca de Alzheimer

GAPI 04/07

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2006 -

Degeneração neuronal associada à doenca de Alzheimer e às encefalopatias causadas por priões

GAI 05/06

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2005 -

Disfunção colinérgica na doença de Alzheimer: avaliação da capacidade neuroprotectora de compostos com acção antioxidante e inibidora das colinesterases

GAI 14/05

PhD Student Fellow

Universidade de Coimbra Faculdade de Medicina

2004 -

O efeito de novos inibidores das colinesterases na neurotoxicidade do peptídeo beta amilóide. Potenciais agentes terapêuticos na doença de Alzheimer

GAI 05/04

Master Student Fellow

Universidade de Coimbra Faculdade de Medicina

2003/09/01 - 2004/12/31

A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies

POCTI/36101/NSE/1999

Master Student Fellow

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

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