Luis Pereira de Almeida

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Information about journal articles, updated at 19-05-2024, from platform CIÊNCIAVITAE.

Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia

Weber, Niklas; Buchholz, Maresa; Rädke, Anika; Faber, Jennifer; Schmitz-Hübsch, Tanja; Jacobi, Heike; Klockgether, Thomas; et al, The Cerebellum. 2024. http://dx.doi.org/10.1007/s12311-024-01657-2 . 10.1007/s12311-024-01657-2 . The Cerebellum

Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol

Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado, JoVE Journal. e66550. 2024. https://www.jove.com/t/66550 . in press JoVE Journal

RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation

Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luís; Campello, Maria Paula Cabral; et al, International Journal of Biological Macromolecules. 259. 2024. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157 . 10.1016/j.ijbiomac.2023.129157 . International Journal of Biological Macromolecules

Viral-based animal models in polyglutamine disorders

Henriques, Carina; Lopes, Miguel M; Silva, Ana C; Lobo, Diana D; Aron Badin, Romina; Hantraye, Philippe; Pereira de Almeida, Luís; Nobre, Rui Jorge, Brain. 2024. http://dx.doi.org/10.1093/brain/awae012 . 10.1093/brain/awae012 . Brain

Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira, Scientific Reports. 1. 14. 2024. http://dx.doi.org/10.1038/s41598-024-53542-x . 10.1038/s41598-024-53542-x . Scientific Reports

Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer’s Disease

Soares Martins, Tânia; Pelech, Steven; Ferreira, Maria; Pinho, Beatriz; Leandro, Kevin; de Almeida, Luís Pereira; Breitling, Benedict; et al, International Journal of Molecular Sciences. 3. 25. 2024. http://dx.doi.org/10.3390/ijms25031584 . 10.3390/ijms25031584 . International Journal of Molecular Sciences

Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation

Maria Soares; Maria M. Pinto; Rui Jorge Nobre; Luís Pereira de Almeida; Maria da Graça Rasteiro; Teresa Almeida-Santos; João Ramalho-Santos; Ana Paula Sousa, Biomolecules. 2023. https://doi.org/10.3390/biom13020278 . 10.3390/biom13020278 . Biomolecules

Consensus Recommendations for Clinical Outcome Assessments and Registry Development in Ataxias: Ataxia Global Initiative (AGI) Working Group Expert Guidance

Klockgether, T.; Synofzik, M.; Alhusaini, S.; Anheim, M.; Antonijevic, I.; Ashizawa, T.; Bataller, L.; et al, Cerebellum. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85151668891&partnerID=MN8TOARS . 10.1007/s12311-023-01547-z . Cerebellum

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

Rufino-Ramos, D.; Albuquerque, P.R.; Leandro, K.; Carmona, V.; Martins, I.M.; Fernandes, R.; Henriques, C.; et al, Molecular Therapy. 1275 - 1292. 5. 31. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85154619372&partnerID=MN8TOARS . 10.1016/j.ymthe.2023.04.001 . Molecular Therapy

SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias

Uebachs, M.; Wegner, P.; Schaaf, S.; Kugai, S.; Jacobi, H.; Kuo, S.-H.; Ashizawa, T.; et al, Cerebellum. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85151467845&partnerID=MN8TOARS . 10.1007/s12311-023-01546-0 . Cerebellum

A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia

Santana, M.M.; Gaspar, L.S.; Pinto, M.M.; Silva, P.; Adão, D.; Pereira, D.; Ribeiro, J.A.; et al, Neuropathology and Applied Neurobiology. 2. 49. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85153765323&partnerID=MN8TOARS . 10.1111/nan.12892 . Neuropathology and Applied Neurobiology

In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration

Patrícia Pereira; Ana S. Neto; Ana S. Rodrigues; Inês Barros; Catarina Miranda; João Ramalho-Santos; Luís Pereira de Almeida; et al, Polymers. 2023. https://doi.org/10.3390/polym15102256 . 10.3390/polym15102256 . Polymers

The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits

Koppenol, R.; Conceição, A.; Afonso, I.T.; Afonso-Reis, R.; Costa, R.G.; Tomé, S.; Teixeira, D.; et al, Brain. 2346 - 2363. 6. 146. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160404450&partnerID=MN8TOARS . 10.1093/brain/awac473 . Brain

Blood transcriptome sequencing identifies biomarkers able to track disease stages in spinocerebellar ataxia type 3

Raposo, M.; Hübener-Schmid, J.; Ferreira, A.F.; Vieira Melo, A.R.; Vasconcelos, J.; Pires, P.; Kay, T.; et al, Brain. 4132 - 4143. 10. 146. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85173781207&partnerID=MN8TOARS . 10.1093/brain/awad128 . Brain

Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes

Carmo-Silva, S.; Ferreira-Marques, M.; Nóbrega, C.; Botelho, M.; Costa, D.; Aveleira, C.A.; Pulst, S.M.; et al, Journal of Molecular Endocrinology. 1. 70. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85143645604&partnerID=MN8TOARS . 10.1530/JME-21-0272 . under revision Journal of Molecular Endocrinology

Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers

Arnaut, Z.A.; Pinto, S.M.A.; Aroso, R.T.; Amorim, A.S.; Lobo, C.S.; Schaberle, F.A.; Pereira, D.; et al, Photochemical and Photobiological Sciences. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85172998540&partnerID=MN8TOARS . 10.1007/s43630-023-00476-4 . Photochemical and Photobiological Sciences

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia

Mariana Martins; Ana Rafaela Oliveira; Solange Martins; José Pedro Vieira; Pedro Perdigão; Ana Rita Fernandes; Luís Pereira de Almeida; et al, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241612603 . 10.3390/ijms241612603 . International Journal of Molecular Sciences

Extracellular communication between brain cells through functional transfer of Cre mRNA

Rufino-Ramos, David; Leandro, K; Perdigão, Pedro; O'Brien, K; Pinto, MM; Santana, MM; van Solinge, TS; et al, Molecular Therapy. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160280091&partnerID=MN8TOARS . 10.1016/j.ymthe.2023.05.012 . in press Molecular Therapy

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome

Ferreira-Marques, M.; Carvalho, A.; Franco, A.C.; Leal, A.; Botelho, M.; Carmo-Silva, S.; Águas, R.; et al, Aging Cell. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85174420928&partnerID=MN8TOARS . 10.1111/acel.13983 . Aging Cell

The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors

Hengel, H.; Martus, P.; Faber, J.; Giunit, P.; Garcia-Moreno, H.; Solanky, N.; Klockgether, T.; et al, Journal of Neurology. 944 - 952. 2. 270. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85141199384&partnerID=MN8TOARS . 10.1007/s00415-022-11441-z . Journal of Neurology

Correction to: The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors

Hengel, Holger; Martus, Peter; Faber, Jennifer; Giunti, Paola; Garcia-Moreno, Hector; Solanky, Nita; Klockgether, Thomas; et al, Journal of Neurology. 628 - 629. 1. 271. 2023. http://dx.doi.org/10.1007/s00415-023-12064-8 . 10.1007/s00415-023-12064-8 . Journal of Neurology

Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases

Brás, J.; Henriques, D.; Moreira, R.; Santana, M.M.; Silva-Pedrosa, R.; Adão, D.; Braz, S.; et al, Scientific Reports. 1. 12. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85134499812&partnerID=MN8TOARS . 10.1038/s41598-022-16369-y . Scientific Reports

Deciphering a new role for Ataxin-2 in the hypothalamus: linking metabolism and circadian rhythm regulation.

Carmo-Silva, Sara; Ferreira-Marques, Marisa; Nóbrega, Clévio David Rodrigues ; Botelho, Mariana; Costa, Daniela G.; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia, Molecular Endocrinology. 2022. under revision Molecular Endocrinology

Editorial: Gene therapy 2.0: Biotechnology for circuit engineering and complex therapeutic approaches

Quintino, L.; Almeida, L.P.D.; Lundberg, C., Frontiers in Bioengineering and Biotechnology. 10. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85143363515&partnerID=MN8TOARS . 10.3389/fbioe.2022.1082883 . Frontiers in Bioengineering and Biotechnology

The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease

Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto Rolim Muro Martinez; Marcondes Cavalcante França Jr; Clévio Nóbrega; et al, Neuropathology and Applied Neurobiology. 2022. https://doi.org/10.1111/nan.12763 . 10.1111/nan.12763 . Neuropathology and Applied Neurobiology

Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity

Holger Hengel; Peter Martus; Jennifer Faber; Hector Garcia-Moreno; Nita Solanky; Paola Giunti; Thomas Klockgether; et al, Movement Disorders. 2022. https://doi.org/10.1002/mds.28844 . 10.1002/mds.28844 . Movement Disorders

Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis

Almeida, S.F.F.; Fonseca, A.; Sereno, J.; Ferreira, H.R.S.; Lapo-Pais, M.; Martins-Marques, T.; Rodrigues, T.; et al, Small. 49. 18. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85141363010&partnerID=MN8TOARS . 10.1002/smll.202203999 . Small

Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins

Koen Breyne; Stefano Ughetto; David Rufino-Ramos; Shadi Mahjoum; Emily A. Grandell; Luís P. de Almeida; Xandra O. Breakefield, Communications Biology. 2022. https://doi.org/10.1038/s42003-022-03440-7 . 10.1038/s42003-022-03440-7 . Communications Biology

Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3

Hector Garcia-Moreno; Mercedes Prudencio; Gilbert Thomas-Black; Nita Solanky; Karen R. Jansen-West; Rana Hanna AL-Shaikh; Amanda Heslegrave; et al, European Journal of Neurology. 2022. https://doi.org/10.1111/ene.15373 . 10.1111/ene.15373 . European Journal of Neurology

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway

Helena Leal; João Cardoso; Patrícia Valério; Marta Quatorze; Vítor Carmona; Janete Cunha-Santos; Luís Pereira de Almeida; et al, International Journal of Molecular Sciences. 6790 - 6790. 12. 23. 2022. https://doi.org/10.3390/ijms23126790 . 10.3390/ijms23126790 . International Journal of Molecular Sciences

Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3

Roderick P.P.W.M. Maas; Steven Teerenstra; Manuela Lima; Paula Pires; Luís Pereira de Almeida; Judith van Gaalen; Dagmar Timmann; et al, Movement Disorders. 2022. https://doi.org/10.1002/mds.29135 . 10.1002/mds.29135 . Movement Disorders

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification

Miguel M. Lopes; Jacques Paysan; José Rino; Sara M. Lopes; Luís Pereira de Almeida; Luísa Cortes; Rui Jorge Nobre, Gene Therapy. 2022. https://doi.org/10.1038/s41434-022-00372-z . 10.1038/s41434-022-00372-z . Gene Therapy

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas, Aging Clinical and Experimental Research. 2022. https://doi.org/10.1007/s40520-022-02257-y . 10.1007/s40520-022-02257-y . Aging Clinical and Experimental Research

Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation

Lobo, C.S.; Rodrigues-Santos, P.; Pereira, D.; Núñez, J.; Trêpa, J.C.D.; Sousa, D.L.; Lourenço, J.V.; et al, Photochemical and Photobiological Sciences. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126514875&partnerID=MN8TOARS . 10.1007/s43630-022-00202-6 . Photochemical and Photobiological Sciences

MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3

Nobre, R.J.; Lobo, D.D.; Henriques, C.; Duarte, S.P.; Lopes, S.M.; Silva, A.C.; Lopes, M.M.; et al, Nucleic Acid Therapeutics. 194 - 205. 3. 32. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85129129262&partnerID=MN8TOARS . 10.1089/nat.2021.0020 . Nucleic Acid Therapeutics

Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado–Joseph disease| Spinocerebellar ataxia type 3

Ana Teresa Simões; Vítor Carmona; Joana Duarte-Neves; Janete Cunha-Santos; Luís Pereira de Almeida, Neuropathology and Applied Neurobiology. 2022. https://doi.org/10.1111/nan.12748 . 10.1111/nan.12748 . Neuropathology and Applied Neurobiology

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease

Miranda, C.O.; Nobre, R.J.; Paiva, V.H.; Duarte, J.V.; Castelhano, J.; Petrella, L.I.; Sereno, J.; et al, Acta Neuropathologica Communications. 1. 10. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126741777&partnerID=MN8TOARS . 10.1186/s40478-022-01329-4 . Acta Neuropathologica Communications

Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo

Rufino-Ramos, D.; Lule, S.; Mahjoum, S.; Ughetto, S.; Cristopher Bragg, D.; Pereira de Almeida, L.; Breakefield, X.O.; Breyne, K., Biomaterials. 281. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122652441&partnerID=MN8TOARS . 10.1016/j.biomaterials.2022.121366 . Biomaterials

ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease

Vasconcelos-Ferreira, A.; Martins, I.M.; Lobo, D.; Pereira, D.; Lopes, M.M.; Faro, R.; Lopes, S.M.; et al, Molecular Therapy. 370 - 387. 1. 30. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115030983&partnerID=MN8TOARS . 10.1016/j.ymthe.2021.07.012 . Molecular Therapy

The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Walter, J.; Bolognin, S.; Poovathingal, S.K.; Magni, S.; Gérard, D.; Antony, P.M.A.; Nickels, S.L.; et al, Cell Reports. 3. 37. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85117275453&partnerID=MN8TOARS . 10.1016/j.celrep.2021.109864 . Cell Reports

Highly specific blood-brain barrier transmigrating single-domain antibodies selected by an in vivo phage display screening

Aguiar, S.I.; Dias, J.N.R.; André, A.S.; Silva, M.L.; Martins, D.; Carrapiço, B.; Castanho, M.; et al, Pharmaceutics. 10. 13. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85116780736&partnerID=MN8TOARS . 10.3390/pharmaceutics13101598 . Pharmaceutics

Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy

Barros, I.; Silva, A.; de Almeida, L.P.; Miranda, C.O., Cytokine and Growth Factor Reviews. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098642605&partnerID=MN8TOARS . 10.1016/j.cytogfr.2020.12.002 . Cytokine and Growth Factor Reviews

Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease

Duarte-Neves, J.; Cavadas, C.; Pereira de Almeida, L., Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100703911&partnerID=MN8TOARS . 10.1038/s41598-021-82339-5 . Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, D.J.; Abdel-Aziz, A.K.; Abdelfatah, S.; Abdellatif, M.; Abdoli, A.; Abel, S.; Abeliovich, H.; et al, Autophagy. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102619204&partnerID=MN8TOARS . 10.1080/15548627.2020.1797280 . Autophagy

Extracellular vesicles physiological role and the particular case of disease-spreading mechanisms in polyglutamine diseases

Moreira, R.; Mendonça, L.S.; de Almeida, L.P., International Journal of Molecular Sciences. 22. 22. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118955937&partnerID=MN8TOARS . 10.3390/ijms222212288 . International Journal of Molecular Sciences

Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy

Marcelo, A.; Afonso, I.T.; Afonso-Reis, R.; Brito, D.V.C.; Costa, R.G.; Rosa, A.; Alves-Cruzeiro, J.; et al, Cell Death and Disease. 8 - 28. 12. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85120082938&partnerID=MN8TOARS . 10.1038/s41419-021-04404-1 . Cell Death and Disease

Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood

Hübener-Schmid, J.; Kuhlbrodt, K.; Peladan, J.; Faber, J.; Santana, M.M.; Hengel, H.; Jacobi, H.; et al, Movement Disorders. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113149446&partnerID=MN8TOARS . 10.1002/mds.28749 . Movement Disorders

Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair

Ana S. Neto; Patrícia Pereira; Ana C. Fonseca; Carla Dias; Mariana C. Almeida; Inês Barros; Catarina O. Miranda; et al, Polymers. 2021. https://doi.org/10.3390/polym13244378 . 10.3390/polym13244378 . Polymers

Living Proof of Activity of Extracellular Vesicles in the Central Nervous System

Shadi Mahjoum; David Rufino-Ramos; Luís Pereira de Almeida; Marike L. D. Broekman; Xandra O. Breakefield; Thomas S. van Solinge; Mahjoum, Shadi; et al, International Journal of Molecular Sciences. 7294 - 7294. 14. 22. 2021. https://doi.org/10.3390/ijms22147294 . 10.3390/ijms22147294 . International Journal of Molecular Sciences

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?

Marcelo, A.; Koppenol, R.; de Almeida, L.P.; Matos, C.A.; Nóbrega, C., Cell Death and Disease. 6. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107594482&partnerID=MN8TOARS . 10.1038/s41419-021-03873-8 . Cell Death and Disease

Simple and Fast Size Exclusion Chromatography-based Protocol to Isolate Human Plasma-derived Extracellular Vesicles for Transcriptional Research

Gaspar, Laetitia S; Magda M Santana; Carina Henriques; Pinto, Maria Manuel ; Teresa M Ribeiro Rodrigues; Girao, Henrique; Rui Jorge Nobre; Pereira de Almeida, Luis , Molecular Therapy - Methods & Clinical Development . 2020. http://dx.doi.org/10.1016/j.omtm.2020.07.012. 10.1016/j.omtm.2020.07.012 . published Molecular Therapy - Methods & Clinical Development

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . The Journals of Gerontology: Series A

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-020-02302-2 . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine

Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies

Lopes, Sara Monteiro; Faro, Rosário; Lopes, Miguel Monteiro; Onofre, Isabel; Mendonça, Nuno; Ribeiro, Joana; Januário, Cristina; Nobre, Rui Jorge; Pereira de Almeida, Luís, The Journal of Molecular Diagnostics. 2020. http://dx.doi.org/10.1016/j.jmoldx.2020.03.003 . 10.1016/j.jmoldx.2020.03.003 . The Journal of Molecular Diagnostics

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Diana Duarte Lobo; Rui Jorge Nobre; Catarina Oliveira Miranda; Dina Pereira; João Castelhano; José Sereno; Arnulf Koeppen; Miguel Castelo-Branco; Luís Pereira de Almeida, Acta Neuropathologica Communications. 2020. https://doi.org/10.1186/s40478-020-00955-0 . 10.1186/s40478-020-00955-0 . Acta Neuropathologica Communications

miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease

Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al, Molecular Therapy - Nucleic Acids. 1219 - 1236. 19. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids

Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice

Wilke, C.; Haas, E.; Reetz, K.; Faber, J.; Garcia-Moreno, H.; Santana, M.M.; van de Warrenburg, B.; et al, EMBO Molecular Medicine. 7. 12. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086096828&partnerID=MN8TOARS . 10.15252/emmm.201911803 . EMBO Molecular Medicine

Mesenchymal Stromal Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?

Barros, I.; Marcelo, A.; Silva, T.P.; Barata, J.; Rufino-Ramos, D.; Pereira de Almeida, L.; Miranda, C.O., Frontiers in Cellular Neuroscience. 14. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85093862610&partnerID=MN8TOARS . 10.3389/fncel.2020.584277 . Frontiers in Cellular Neuroscience

Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research

Laetitia S. Gaspar; Magda M. Santana; Carina Henriques; Maria M. Pinto; Teresa M. Ribeiro-Rodrigues; Henrique Girão; Rui Jorge Nobre; Luís Pereira de Almeida, Molecular Therapy - Methods & Clinical Development. 2020. https://doi.org/10.1016/j.omtm.2020.07.012 . 10.1016/j.omtm.2020.07.012 . Molecular Therapy - Methods & Clinical Development

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C., Frontiers in Cell and Developmental Biology. 8. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS . 10.3389/fcell.2020.576592 . Frontiers in Cell and Developmental Biology

Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation

Henriques, Daniel; Moreira, Ricardo; Schwamborn, Jens; Pereira de Almeida, Luís; Mendonça, Liliana S., Frontiers in Neuroscience. 13. 2019. http://dx.doi.org/10.3389/fnins.2019.01194 . 10.3389/fnins.2019.01194 . Frontiers in Neuroscience

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.

Almeida, Luis, Stem cell reports. 2019. http://europepmc.org/articles/PMC6522948 . 10.1016/j.stemcr.2019.03.004 . Stem cell reports

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models

Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A.; Alves-Cruzeiro, Joao; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al, Human molecular genetics. 51 - 63. 1. 28. 2019. http://hdl.handle.net/10400.1/14482 . 10.1093/hmg/ddy328 . Human molecular genetics

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

Ana C Silva; Diana D Lobo; Inês M Martins; Sara M Lopes; Carina Henriques; Sónia P Duarte; Jean-Cosme Dodart; Rui Jorge Nobre; Luis Pereira de Almeida, Brain. 2019. https://doi.org/10.1093/brain/awz328 . 10.1093/brain/awz328 . Brain

RNA interference therapy for Machado-Joseph disease: Long-term safety profile of lentiviral vectors encoding short hairpin RNAs targeting mutant ataxin-3

Nóbrega, Clévio; Codesso, Jose Miguel; Mendonca, Liliana; de Almeida, Luis Pereira, 2019. http://hdl.handle.net/10400.1/14340 . 10.1089/hum.2018.157 .

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

Nóbrega, Clévio; Mendonca, Liliana; Marcelo, Adriana; Lamaziere, Antonin; Tome, Sandra; Despres, Gaetan; Matos, Carlos A; et al, Acta Neuropathologica. 2019. http://hdl.handle.net/10400.1/14197 . 10.1007/s00401-019-02019-7 . Acta Neuropathologica

Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington´s Disease patient-derived pluripotent and neural stem cells

Lopes, Carla; Schlaeger, Thorsten; Pereira de Almeida, Luis ; Daley, George Q.; Ana Cristina Carvalho Rego, European Journal of Clinical Investigation. 53 - 100. S1. 49. 2019. http://dx.doi.org/10.1111/eci.13108 . 10.1111/eci.13108 . European Journal of Clinical Investigation

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

Liliana S Mendonça; Clévio Nóbrega; Silvia Tavino; Maximilian Brinkhaus; Carlos Matos; Sandra Tomé; Ricardo Moreira; et al, Human Molecular Genetics. 2019. https://doi.org/10.1093/hmg/ddz097 . 10.1093/hmg/ddz097 . Human Molecular Genetics

Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Rodrigues, C.F.D.; Serrano, E.; Patrício, M.I.; Val, M.M.; Albuquerque, P.; Fonseca, J.; Gomes, C.M.F.; et al, Scientific Reports. 1. 8. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050990420&partnerID=MN8TOARS . 10.1038/s41598-018-29947-w . Scientific Reports

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice

Marques, A.P.; Cunha-Santos, J.; Leal, H.; Sousa-Ferreira, L.; Pereira de Almeida, L.; Cavadas, C.; Rosmaninho-Salgado, J., Biochimica et Biophysica Acta - General Subjects. 403 - 413. 3. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037668547&partnerID=MN8TOARS . 10.1016/j.bbagen.2017.11.012 . Biochimica et Biophysica Acta - General Subjects

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs

Pólvora-Brandão, D.; Joaquim, M.; Godinho, I.; Aprile, D.; Álvaro, A.R.; Onofre, I.; Raposo, A.C.; et al, Human molecular genetics. 3999 - 4011. 23. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056694837&partnerID=MN8TOARS . 10.1093/hmg/ddy274 . Human molecular genetics

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al, Molecular Therapy. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS . 10.1016/j.ymthe.2018.07.007 . Molecular Therapy

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia

Gonçalves, N.; Simões, A.T.; Prediger, R.D.; Hirai, H.; Cunha, R.A.; Pereira de Almeida, L., Annals of Neurology. 407 - 418. 3. 81. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS . 10.1002/ana.24867 . Annals of Neurology

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

Rufino-Ramos, D.; Albuquerque, P.R.; Carmona, V.; Perfeito, R.; Nobre, R.J.; Pereira de Almeida, L., Journal of Controlled Release. 247 - 258. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026758579&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.001 . Journal of Controlled Release

Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration

Cristo, F.; Inácio, J.M.; Rosas, G.; Carreira, I.M.; Melo, J.B.; de Almeida, L.P.; Mendes, P.; et al, Stem Cell Research. 152 - 156. 25. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033403571&partnerID=MN8TOARS . 10.1016/j.scr.2017.10.019 . Stem Cell Research

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2

Hachigian, L.J.; Carmona, V.; Fenster, R.J.; Kulicke, R.; Heilbut, A.; Sittler, A.; Pereira de Almeida, L.; et al, Cell Reports. 2688 - 2695. 10. 21. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038085324&partnerID=MN8TOARS . 10.1016/j.celrep.2017.11.018 . Cell Reports

Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis

Matos, C.A.; de Almeida, L.P.; Nóbrega, C., Current Pharmaceutical Design. 753 - 775. 5. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS . 10.2174/1381612822666161227121912 . Current Pharmaceutical Design

Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease

Carmona, V.; Cunha-Santos, J.; Onofre, I.; Simões, A.T.; Vijayakumar, U.; Davidson, B.L.; Pereira de Almeida, L., Molecular Therapy. 1038 - 1055. 4. 25. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016966764&partnerID=MN8TOARS . 10.1016/j.ymthe.2017.01.021 . Molecular Therapy

Unraveling the Role of Ataxin-2 in Metabolism

Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C., Trends in Endocrinology and Metabolism. 309 - 318. 4. 28. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS . 10.1016/j.tem.2016.12.006 . Trends in Endocrinology and Metabolism

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Biomaterials. 124 - 137. 82. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS . 10.1016/j.biomaterials.2015.12.021 . Biomaterials

Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

Onofre, I.; Mendonça, N.; Lopes, S.; Nobre, R.; De Melo, J.B.; Carreira, I.M.; Januário, C.; Gonçalves, A.F.; De Almeida, L.P., Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975709020&partnerID=MN8TOARS . 10.1038/srep28220 . Scientific Reports

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway

Cunha-Santos, J.; Duarte-Neves, J.; Carmona, V.; Guarente, L.; De Almeida, L.P.; Cavadas, C., Nature Communications. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968928647&partnerID=MN8TOARS . 10.1038/ncomms11445 . Nature Communications

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9

Saraiva, J.; Nobre, R.J.; Pereira de Almeida, L., Journal of Controlled Release. 94 - 109. 241. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988451695&partnerID=MN8TOARS . 10.1016/j.jconrel.2016.09.011 . Journal of Controlled Release

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation

Ferreira-Marques, M.; Aveleira, C.A.; Carmo-Silva, S.; Botelho, M.; de Almeida, L.P.; Cavadas, C., Aging. 1470 - 1484. 7. 8. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014143445&partnerID=MN8TOARS . 10.18632/aging.100996 . Aging

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Data in Brief. 700 - 705. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS . 10.1016/j.dib.2016.01.017 . Data in Brief

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABA<inf>A</inf> Receptor Clustering and Contributes to Neuronal Death

Costa, J.T.; Mele, M.; Baptista, M.S.; Gomes, J.R.; Ruscher, K.; Nobre, R.J.; de Almeida, L.P.; Wieloch, T.; Duarte, C.B., Molecular Neurobiology. 3513 - 3527. 6. 53. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931863889&partnerID=MN8TOARS . 10.1007/s12035-015-9283-2 . Molecular Neurobiology

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Duarte-Neves, J.; Pereira de Almeida, L.; Cavadas, C., Neurobiology of Disease. 210 - 214. 95. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979934564&partnerID=MN8TOARS . 10.1016/j.nbd.2016.07.022 . Neurobiology of Disease

Motor dysfunctions and neuropathology in mouse models of spinocerebellar ataxia type 2: A comprehensive review

Da Conceição Alves-Cruzeiro, J.M.; Mendonça, L.; De Almeida, L.P.; Nóbrega, C., Frontiers in Neuroscience. DEC. 10. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009729313&partnerID=MN8TOARS . 10.3389/fnins.2016.00572 . Frontiers in Neuroscience

Adenosine A<inf>2A</inf> receptors in the amygdala control synaptic plasticity and contextual fear memory

Simões, A.P.; MacHado, N.J.; Gonçalves, N.; Kaster, M.P.; Simões, A.T.; Nunes, A.; Pereira De Almeida, L.; et al, Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS . 10.1038/npp.2016.98 . Neuropsychopharmacology

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

Duarte-Neves, J.; Gonçalves, N.; Cunha-Santos, J.; Simões, A.T.; den Dunnen, W.F.A.; Hirai, H.; Kügler, S.; Cavadas, C.; de Almeida, L.P., Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS . 10.1093/hmg/ddv271 . Human Molecular Genetics

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease

Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L., Brain. 3537 - 3554. 12. 138. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951031850&partnerID=MN8TOARS . 10.1093/brain/awv298 . Brain

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, C.A.; Botelho, M.; Carmo-Silva, S.; Pascoal, J.F.; Ferreira-Marques, M.; Nóbrega, C.; Cortes, L.; et al, Proceedings of the National Academy of Sciences of the United States of America. E1642 - E1651. 13. 112. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926180461&partnerID=MN8TOARS . 10.1073/pnas.1416609112 . Proceedings of the National Academy of Sciences of the United States of America

MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma

Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C., Journal of Controlled Release. 31 - 39. 207. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS . 10.1016/j.jconrel.2015.04.002 . Journal of Controlled Release

Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice

Mendonça, L.S.; Nóbrega, C.; Hirai, H.; Kaspar, B.K.; De Almeida, L.P., Brain. 320 - 335. 2. 138. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922366384&partnerID=MN8TOARS . 10.1093/brain/awu352 . Brain

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al, Cell Metabolism. 626 - 638. 4. 20. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS . 10.1016/j.cmet.2014.09.001 . Cell Metabolism

Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro

Sousa-Ferreira, L.; Aveleira, C.; Botelho, M.; Álvaro, A.R.; Pereira De Almeida, L.; Cavadas, C., PLoS ONE. 3. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897138484&partnerID=MN8TOARS . 10.1371/journal.pone.0088917 . PLoS ONE

RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease

Nóbrega, C.; Nascimento-Ferreira, I.; Onofre, I.; Albuquerque, D.; Déglon, N.; De Almeida, L.P., PLoS ONE. 8. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929055238&partnerID=MN8TOARS . 10.1371/journal.pone.0100086 . PLoS ONE

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease

Simões, A.T.; Gonçalves, N.; Nobre, R.J.; Duarte, C.B.; Pereira de Almeida, L., Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS . 10.1093/hmg/ddu209 . Human Molecular Genetics

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

Guedes, J.R.; Custódia, C.M.; Silva, R.J.; de Almeida, L.P.; de Lima, M.C.P.; Cardoso, A.L., Human Molecular Genetics. 6286 - 6301. 23. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926341070&partnerID=MN8TOARS . 10.1093/hmg/ddu348 . Human Molecular Genetics

IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina, Molecular Neurobiology. 0 - 0. 0. 2013. 10.1007/s12035-013-8585-5 . published Molecular Neurobiology

Role of hypothalamic neurogenesis in feeding regulation

Sousa-Ferreira, Lígia; Almeida, Luís Pereira de; Cavadas, Cláudia, Trends in Endocrinology & Metabolism. 1 - 9. .. 2013. http://www.cell.com/trends/endocrinology-metabolism//retrieve/pii/S1043276013001744?_returnURL=http://linkinghub.elsevier.com/retrieve/pii/S1043276013001744?showall=true . 10.1016/j.tem.2013.10.005 . published Trends in Endocrinology & Metabolism

Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

Gonçalves, Nélio; Simões, Ana T.; Cunha, Rodrigo A.; de Almeida, Luís Pereira; Almeida, Luís Pereira de, Annals of Neurology. 655 - 666. 5. 73. 2013. http://hdl.handle.net/10316/28116 . 10.1002/ana.23866 . published Annals of Neurology

Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira; Chiesa, Roberto, PLoS ONE. e52396 - e52396. 1. 8. 2013. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052396 . 10.1371/journal.pone.0052396 . published PLoS ONE

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

Nascimento-Ferreira, I.; Nobrega, C.; Vasconcelos-Ferreira, A.; Onofre, I.; Albuquerque, D.; Aveleira, C.; Hirai, H.; Deglon, N.; Pereira de Almeida, L, Brain. 2173 - 2188. 7. 136. 2013. http://brain.oxfordjournals.org/cgi/content/full/awt144? ijkey=5Fgyaqt9oIUEAui&keytype=ref . 10.1093/brain/awt144 . published Brain

Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology

Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; Almeida, Luís Pereira, The Cerebellum. 0 - 0. 0. 2012. 10.1007/s12311-012-0432-0 . published The Cerebellum

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma

Costa, P. M.; Cardoso, A. L.; Nobrega, C.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C., Human Molecular Genetics. 0 - 0. 0. 2012. 10.1093/hmg/dds496 . published Human Molecular Genetics

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

Cardoso, Ana L.; Guedes, Joana R.; Pereira de Almeida, Luís; Pedroso de Lima, Maria C., Immunology. 73 - 88. 1. 135. 2012. 10.1111/j.1365-2567.2011.03514.x . published Immunology

PDGF-B-mediated downregulation of miR-21: new insights into PDGF signaling in glioblastoma

Costa, P. M.; Cardoso, A. L.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C., Human Molecular Genetics. 0 - 0. 0. 0. 2012. 10.1093/hmg/dds358 . published Human Molecular Genetics

Cleavage of the Vesicular GABA Transporter under Excitotoxic Conditions Is Followed by Accumulation of the Truncated Transporter in Nonsynaptic Sites

Gomes, J. R.; Lobo, A. C.; Melo, C. V.; Inacio, A. R.; Takano, J.; Iwata, N.; Saido, T. C.; et al, Journal of Neuroscience. 4622 - 4635. 12. 31. 2011. 10.1523/JNEUROSCI.3541-10.2011 . published Journal of Neuroscience

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

Nascimento-Ferreira, I.; Santos-Ferreira, T.; Sousa-Ferreira, L.; Auregan, G.; Onofre, I.; Alves, S.; Dufour, N.; et al, Brain. 1400 - 1415. 5. 134. 2011. 10.1093/brain/awr047 . published Brain

Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats

Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al, PLoS ONE. 22333 - 22333. 7. 6. 2011. 10.1371/journal.pone.0022333 . published PLoS ONE

Gene Therapy for Parkinson's and Alzheimer's Diseases: from the Bench to Clinical Trials

Jorge Nobre, Rui; Pereira de Almeida, Luis, Current Pharmaceutical Design. 3434 - 3445. 31. 17. 2011. 10.2174/138161211798072472 . published Current Pharmaceutical Design

Células Estaminais Pluripotentes Induzidas (IPSCS) – A mais recente revolução das ciências da vida e da saúde

Pereira de Almeida, Luis Fernando Morgado, BOLETIM DO CIM - ROF 97 Mar/Abr 2011. 5 - 6. 97. 2011. published BOLETIM DO CIM - ROF 97 Mar/Abr 2011

Beclin-1 and autophagy: potential for new therapeutics in neurodegeneration

Pereira de Almeida, Luis Fernando Morgado; Nascimento-Ferreira, I., Neurodegenerative Disease Management. 349 - 351. 5. 1. 2011. http://www.futuremedicine.com/doi/full/10.2217/nmt.11.56 . published Neurodegenerative Disease Management

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia; Linden, Rafael, PLoS ONE. 19745 - 19745. 5. 6. 2011. 10.1371/journal.pone.0019745 . published PLoS ONE

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al, Human Molecular Genetics. 2380 - 2394. 12. 19. 2010. 10.1093/hmg/ddq111 . published Human Molecular Genetics

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Controlled Release. 392 - 403. 3. 142. 2010. 10.1016/j.jconrel.2009.11.004 . published Journal of Controlled Release

Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing

Nobre, Rui Jorge; Cruz, Eugénia; Real, Odete; de Almeida, Luís Pereira; Martins, Teresa C., Journal of Medical Virology. 1024 - 1032. 6. 82. 2010. 10.1002/jmv.21756 . published Journal of Medical Virology

Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

Alves, Sandro; Nascimento-Ferreira, Isabel; Auregan, Gwennaëlle; Hassig, Raymonde; Dufour, Noëlle; Brouillet, Emmanuel; Pedroso de Lima, Maria C.; et al, PLoS ONE. 3341 - 3341. 10. 3. 2008. 10.1371/journal.pone.0003341 . published PLoS ONE

Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS

Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C., Journal of Controlled Release. 113 - 123. 2. 132. 2008. 10.1016/j.jconrel.2008.08.014 . published Journal of Controlled Release

Surfactants as Microbicides and Contraceptive Agents: A Systematic In Vitro Study

Vieira, Otilia V.; Hartmann, Diego O.; Cardoso, Carla M. P.; Oberdoerfer, Daniel; Baptista, Marta; Santos, Manuel A. S.; Almeida, Luis; et al, PLoS ONE. 2913 - 2913. 8. 3. 2008. 10.1371/journal.pone.0002913 . published PLoS ONE

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Alves, S.; Regulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A. L.; et al, Human Molecular Genetics. 2071 - 2083. 14. 17. 2008. 10.1093/hmg/ddn106 . published Human Molecular Genetics

siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing

Cardoso, A. L. C.; Simões, S.; de Almeida, L. P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M. C., The Journal of Gene Medicine. 170 - 183. 3. 9. 2007. 10.1002/jgm.1006 . published The Journal of Gene Medicine

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury

Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C, Gene Therapy. 1242 - 1252. 16. 12. 2005. 10.1038/sj.gt.3302516 . published Gene Therapy

Molecular Targets and Therapeutic Strategies in Huntington's Disease

Rego, A. C.; de Almeida, L. P., Current Drug Targets - CNS & Neurological Disorders. 361 - 381. 4. 4. 2005. 10.2174/1568007054546081 . published Current Drug Targets - CNS & Neurological Disorders

Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System

P. de Lima, M. C.; Girao da Cruz, M. T.; C. Cardoso, A. L; Simoes, S.; de Almeida, L. P., Current Drug Targets - CNS & Neurological Disorders. 453 - 465. 4. 4. 2005. 10.2174/1568007054546144 . published Current Drug Targets - CNS & Neurological Disorders

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

Zala, Diana; Bensadoun, Jean-Charles; Pereira de Almeida, Luis; Leavitt, Blair R.; Gutekunst, Claire-Anne; Aebischer, Patrick; Hayden, Michael R.; Déglon, Nicole, Experimental Neurology. 26 - 35. 1. 185. 2004. http://www.sciencedirect.com/science/article/pii/S0014488603004436 . 10.1016/j.expneurol.2003.09.002 . published Experimental Neurology

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

Bensadoun, Jean-Charles; Pereira de Almeida, Luis; Fine, Eric G; Tseng, Jack L; Déglon, Nicole; Aebischer, Patrick, Journal of Controlled Release. 107 - 115. 1-3. 87. 2003. 10.1016/S0168-3659(02)00353-X . published Journal of Controlled Release

Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length

De Almeida, L.P.; Ross, C.A.; Zala, D.; Aebischer, P.; Déglon, N., Journal of Neuroscience. 3473 - 3483. 9. 22. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036580677&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3278-01.2002 . Journal of Neuroscience

Dose-Dependent Neuroprotective Effect of Ciliary Neurotrophic Factor Delivered via Tetracycline-Regulated Lentiviral Vectors in the Quinolinic Acid Rat Model of Huntington's Disease

Régulier, E.; Pereira de Almeida, L.; Sommer, B.; Aebischer, P.; Déglon, N., Human Gene Therapy. 1981 - 1990. 16. 13. 2002. 10.1089/10430340260355383 . published Human Gene Therapy

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

Bensadoun, Jean-Charles; de Almeida, Luis Pereira; Dreano, Michel; Aebischer, Patrick; Deglon, Nicole; Bensadoun, J.-C.; Pereira de Almeida, L.; et al, European Journal of Neuroscience. 1753 - 1761. 11. 14. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035783942&partnerID=MN8TOARS . 10.1046/j.0953-816x.2001.01802.x . published European Journal of Neuroscience

Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease

de Almeida, L.Pereira; Zala, D.; Aebischer, P.; Déglon, N., Neurobiology of Disease. 433 - 446. 3. 8. 2001. 10.1006/nbdi.2001.0388 . published Neurobiology of Disease

Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease

Deglon, Nicole; Tseng, Jack L.; Bensadoun, Jean-Charles; Zurn, Anne D.; Arsenijevic, Yvan; Almeida, Luis Pereira De; Zufferey, Romain; Trono, Didier; Aebischer, Patrick, Human Gene Therapy. 179 - 190. 1. 11. 2000. 10.1089/10430340050016256 . published Human Gene Therapy

Modeling dissolution of sparingly soluble multisized powders

Pereira de Almeida, Luis ; Simões, Sérgio; Brito, Paulo; Portugal, António; Figueiredo, Margarida, Journal of Pharmaceutical Sciences. 726 - 732. 6. 86. 1997. 10.1021/js960417w . published Journal of Pharmaceutical Sciences

Testing the applicability of classical diffusional models to polydisperse systems

Simöes, Sérgio; Pereira de Almeida, Luis; Figueiredo, Margarida, International Journal of Pharmaceutics. 169 - 176. 1-2. 139. 1996. 10.1016/0378-5173(96)04596-6 . published International Journal of Pharmaceutics

All projects

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Information of exclusive responsibility of the researcher 19-05-2024 , from platform CIÊNCIAVITAE.

2024/01 - 2029/12

GeneT - The Gene Therapy CoE at the Center of Portugal

Grant agreement ID: 101059981

Principal investigator

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia; Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: European Commission

2023/09/01 - 2026/08/31

NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)

JPND/0001/2022

Universidade de Coimbra; CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory; CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/03/01 - 2024/08/31

From “bedside-to-bench” biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease

2022.06118.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/01/01 - 2025/12/31

CInTech: Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs

C644865576-00000005

Universidade de Coimbra; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Quadro de Referência Estratégico Nacional (QREN)

2023/03/01 - 2024/08/31

Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 – towards the understanding of the neuroprotective mechanism

2022.04788.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/02/01 - 2024/07/31

Exploring mitophagy to rescue neurological syndromes in mitochondrial diseases

2022.04458.PTDC

Rede de Química e Tecnologia Laboratório Associado para a Química Verde

Funders: Fundação para a Ciência e a Tecnologia

2023/03/01 - 2024/08/31

Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3

2022.06127.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2022/07/01 - 2023/06/30

MJDedit - Sistemas de edição génica para o gene ATXN3: Uma terapia para a doença de Machado-Joseph

CENTRO-01-0145-FEDER-181266

Universidade de Coimbra

Funders: Autoridade de Gestão do Programa Operacional CENTRO2020

2022/01/01 - 2023/06/30

Genome editing to rescue Machado-Joseph disease by alternative splicing

EXPL/MED-NEU/0936/2021

Universidade de Coimbra; CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia

2021 -

Protoloco CNC e Exogenus Therapeutics

NA

2021/03/01 - 2024/02/29

Assessing aging of human neurons by direct induced neuronal iN conversion

PTDC/MED-NEU/3890/2020

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2025/10/31

Accelerating Research & Development for Advanced Therapies (ARDAT)

945473

Innovative Health Initiative

Funders: European Union; European Federation of Pharmaceutical Industries and Associations; European Commission

2020/01/01 - 2024/12/31

Center for Innovative Biomedicine and Biotechnology

UIDB/04539/2020

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2020/08/01 - 2023/06/30

Fighting Sars-CoV-2 with Viral Vectors

CENTRO-01-01D2-FEDER-000002

Principal investigator

Universidade de Coimbra

Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro

2020/10/01 - 2023/06/30

ReSet - Development of a food supplement based on Resveratrol for optimal CNS activity

CENTRO-01-0247-FEDER-070162

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro

2020/01/01 - 2024/12/31

Center for Innovative Biomedicine and Biotechnology

UIDP/04539/2020

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2020 - 2023

miRSilencing

NA

Funders: PTC Therapeutics Inc

2020 -

Collaboration agreement - F. Hoffmann - La Roche Ltd (Roche Group)

NA

CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: F Hoffmann-La Roche AG Research and Development Division; F Hoffmann-La Roche AG

2020 - 2023

miRSilencing

NA

Funders: PTC Therapeutics Inc

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07/06 - 2022/04/05

Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy

PTDC/MED-NEU/32309/2017

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2018/10/13 - 2022/04/12

The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy

PTDC/MED-NEU/29480/2017

Universidade do Algarve; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2018/06/15 - 2022/06/14

The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease.

PTDC/BTM-ORG/30737/2017

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07/01 - 2022/06/30

Blocking neurodegeneration by spreading of gene silencers

PTDC/BTM-SAL/29716/2017

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2018/01/07 - 2021/06/30

SpreadSilencing - Neurodegeneration blocking by genetic silencers dispersion, FCT-Portuguese Foundation for Science and Technology. POCI-01-0145-FEDER-029716. Principal investigator

POCI-01-0145-FEDER-029716

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2018/06/01 - 2021/12/31

NiNjA - New Neuroendocrine Strategy for healthy Aging.

PTDC/MED-FAR/30167/2017

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2018/07/26 - 2022/07/25

The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology

PTDC/MED-NEU/28214/2017

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2019

Calpain inhibition as a therapeutic strategy in Machado-Joseph disease.

Calpain Targeted Inhibition

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Blade Therapeutics, Inc

2018 - 2019

uniQure - REF. Collaboration agreement_uniQure biopharma B.V.

Collaboration agreement_uniQure biopharma B.V

CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory; CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: uniQure biopharma BV

2017/01/01 - 2021/06/30

Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy

SAICTPAC/0022/2015

Universidade do Porto Instituto de Patologia e Imunologia Molecular; Instituto Nacional de Engenharia Biomédica; Fundação Calouste Gulbenkian; Universidade de Coimbra; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2017/03/01 - 2022/03/31

ViraVerctor - Viral Vectors for Gene Transfer Core Facility

PINFRA/22095/2016

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2017/04/01 - 2019/06/30

NanoBiomateriais poliméricos para libertação de fármacos: Desenvolvimento e implementação co conceito "safe-by-design" permitindo soluções seguras em cuidados de saúde

ProSafe/0001/2016

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/04/01 - 2019/12/31

Gene repair and repression strategies to alleviate Machado-Joseph disease

PTDC/NEU-NMC/0084/2014

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2016/04/01 - 2020/03/31

Advanced models of polyglutamine disorders

JPCOFUND/0005/2015

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2016/09 - 2019/09

JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative

grant.MR/N028767/1

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Medical Research Council; Fundação para a Ciência e a Tecnologia

2016/05/01 - 2019/10/31

Control of cardiomyocyte proliferation in disease and regenerative medicine

PTDC/BIM-MED/3363/2014

Universidade Nova de Lisboa Faculdade de Ciências Médicas; iNOVA4Health; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2016/01 - 2018/12

Gene repair and repression strategies to alleviate Machado-Joseph disease

Provided by PTCRIS: 138667

Funders: Fundação para a Ciência e a Tecnologia

2016/06/01 - 2019/12/31

Imaging Gene Therapy in the Brain

PTDC/BBB-NAN/0932/2014

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia

2015/01/01 - 2017/12/31

CNC.IBILI

UID/NEU/04539/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015/03/01 - 2018/12/31

Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases

JPND-CD/0001/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2014/03 - 2015/09

Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing

grant.Provided by PTCRIS: 135805

Funders: Fundação para a Ciência e a Tecnologia

2014 - 2016

Cabaletta@CNC

NA

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Bioblast Pharma

2014/03/01 - 2015/09/30

Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo

EIT-KIC/IVE/0043/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Administração Regional de Saúde do Centro IP; Universidade de Coimbra Instituto de Investigação Interdisciplinar; Universidade de Coimbra; Universidade de Coimbra Faculdade de Medicina

Funders: Fundação para a Ciência e a Tecnologia

2013/01/01 - 2014/12/14

Strategic Project LA 1 2013-2014

PEstC/ SAU/LA0001/2013

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2016

Caffeine alleviation of MJD/SCA3

2013 41(1)

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation

2013/03 - 2016/02

Towards the Understanding of Pathological Protein Processing and Toxicity in Machado-Joseph Disease.

E-Rare4/0003/2012

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Research Area Board

2013/03 - 2016/12

Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration

Provided by PTCRIS: 132829PRJ

Funders: Fundação para a Ciência e a Tecnologia

2013 -

Viravector - Infrastructure of the national roadmap for production and research with viral vectors

CENTRO-01-0145-FEDER-022095

Principal investigator

2012/01/24 - 2015/07/30

Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells

PTDC/SAU-NMC/116512/2010

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia; Fundação para a Ciência e a Tecnologia, I.P.

2012/04 - 2015/03

Non-invasive-Non-viral Silencing of Machado-Joseph disease

116535

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.; Fundação para a Ciência e a Tecnologia

2011/01/01 - 2012/12/31

Strategic Project - LA 1 - 2011-2012

PEst-C/SAU/LA0001/2011

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/04/01 - 2014/09/30

Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?

PTDC/SAU-NMC/109955/2009

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/03 - 2015/02

TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases

grant.264508

Funders: European Commission

2010/12 - 2012/12

Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease.

SB/NF/2010/2008 Number 15079CA

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: AFM-Téléthon

2010/02/05 - 2013/04/30

The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors

PTDC/SAU-NEU/099307/2008

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia; Fundação para a Ciência e a Tecnologia, I.P.

2010/03/18 - 2012/02/29

Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage

PTDC/SAU-NEU/108668/2008

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/04/01 - 2013/07/15

Caloric restriction increases lifespan: role of neuropeptide Y on autophagy

PTDC/SAU-FCF/099082/2008

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/07 - 2010/12

Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3

70384

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia, I.P.; Fundação para a Ciência e a Tecnologia

2005/09/01 - 2008/08/31

Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs

POCI/SAU-MMO/56055/2004

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia; Fundação para a Ciência e a Tecnologia, I.P.

2005/09 - 2008/08

Transcription regulation by FK506 and BDNF control mitochondrial dependent cell death - a protective role in Huntington's disease

grant.Provided by PTCRIS: 57310

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia

Funders: Fundação para a Ciência e a Tecnologia; Fundação para a Ciência e a Tecnologia

1998/02/01 - 2001/03/31

SISTEMAS POLIMÉRICOS CONTENDO FACTORES NEUROTRÓFICOS PARA TERAPIA DE DOENÇA NEURODEGENERATIVA

PRAXIS XXI/BD/9469/96

Funders: Fundação para a Ciência e a Tecnologia

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