Mariana Raquel Antunes Colaço

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PhD Student

Overview

Mariana Colaço completed in 2016 the Bachelor Degree in Biochemistry (University of Coimbra, Faculty of Science and Technology), and the Master Degree in Pharmaceutical Biotechnology in 2018 with a dissertation entitled "Development of nanosized glucan particles with immunostimulatory function as a delivery system for curcumin" (University of Coimbra, Faculty of Pharmacy). Currently, she is a PhD student in Pharmaceutical Sciences (Pharmaceutical Technology) in Faculty of Pharmacy (University of Coimbra) working on the project: "Designing cationic polymer-DNA complexes for nasal immunization against SARS-CoV-2". Since the completion of her MsD (2018), Mariana Colaço has published 2 articles as first author and 4 articles as co-author. She participated as a Master Student Fellow in 2 projects: an international PROSAFE project (GoNanoBioMat) and a project for the development of a therapeutic vaccine against chronic hepatitis B using glucan based adjuvant nanocarriers. In her professional activities has interacted with 15 collaborators/ co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: Polymeric; nanoparticles; curcumin; glucan; immunotoxicity; anti-inflammatory; therapeutic; safe-by-design; in vitro; immune response.

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends

Jesus, Sandra; Bernardi, Natalia; da Silva, Jessica; Colaço, Mariana; Panão Costa, João; Fonte, Pedro; Borges, Olga, Chemical Research in Toxicology. 2819 - 2833. 11. 33. 2020. http://dx.doi.org/10.1021/acs.chemrestox.0c00208 . 10.1021/acs.chemrestox.0c00208 . published Chemical Research in Toxicology

Airborne environmental fine particles induce intense inflammatory response regardless of the absence of heavy metal elements

Colaço, Mariana; Duarte, Alana; Zuzarte, Mónica; Costa, Benilde F.O.; Borges, Olga, Ecotoxicology and Environmental Safety. 195. 2020. http://dx.doi.org/10.1016/j.ecoenv.2020.110500 . 10.1016/j.ecoenv.2020.110500 . published Ecotoxicology and Environmental Safety

Safe-by-Design of Glucan Nanoparticles: Size Matters When Assessing the Immunotoxicity

Colaço, Mariana; Marques, Ana P.; Jesus, Sandra; Duarte, Alana; Borges, Olga, Chemical Research in Toxicology. 2020. http://dx.doi.org/10.1021/acs.chemrestox.9b00467 . 10.1021/acs.chemrestox.9b00467 . published Chemical Research in Toxicology

Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility

Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al, Frontiers in Bioengineering and Biotechnology. 100. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00100 . 10.3389/fbioe.2020.00100 . published Frontiers in Bioengineering and Biotechnology

Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases its Immunotoxicity

Silva, Jessica; Jesus, Sandra; Benardi, Natália; Colaço, Mariana; Borges, Olga, Frontiers in Bioengineering and Biotechnology. 2019. https://doi.org/10.3389/fbioe.2019.00137 . published Frontiers in Bioengineering and Biotechnology

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2019/11/20 - 2020/11/19

Hepatitis B therapeutic vaccine: Production of glucan-based nanoparticles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity

PTDC/MEC-GAS/30331/2017

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

2017/04/01 - 2019/06/30

Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions

ProSafe/0001/2016

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

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