Overview

Teresa Cunha-Oliveira, a biochemist and cell biologist, earned her PhD from the University of Coimbra (Portugal) in 2007. Her experimental work focused on identifying mitochondrial health biomarkers and developing mitochondria-targeted interventions for various human conditions. Recently, Teresa expanded her expertise into computational biology, data science, and research data management, gaining skills in SQL, Python, R, Microsoft Power BI. Microsoft Excel (Advanced) and MATLAB. She also contributed to implementing ISO 9001 quality management systems at the MitoXT service facility at the Center for Neuroscience and Cell Biology, University of Coimbra, having gained hands-on experience on improving research excellence and standardization. She also gained competencies in machine learning and data visualization aiming to further enhance the reproducibility of research data analysis and communication. Notably, Teresa is currently involved in two European projects: Era Chair EXCELScIOR: EXCELlent Science with Impact, Open and Reliable (GA 101087416) and PasGras - De-risking metabolic, environmental, and behavioral determinants of obesity in children, adolescents, and young adults (GA 101080329). Her bibliometric record includes an Hf index of 30 with 2305 citations (Scopus), 45 research papers, 16 reviews, and 17 book chapters. Her recent review on “Best practices for data management and sharing in experimental biomedical research” was published in Physiological Reviews, the top journal in Physiology (IF 2023 = 29.9). Teresa has supervised and co-supervised students at various institutions and academic levels, also securing two funded grants as principal investigator totaling €263.7k. She is active in training initiatives and served on various academic juries, demonstrating her commitment to mentoring the next generation of scientists. As an example, she co-organized several advanced courses on “Experimental Research Design” and led several workshops promoting best practices in biomedical research. She is particularly interested in creating user-friendly research data management workflows tailored to experimental biomedical scientists, aimed to enhance researcher engagement with best research practices for data handling and analysis . (Metrics updated on 26 July 2024)

Publications

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Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.

Heterogeneous redox responses in NHDF cells primed to enhance mitochondrial bioenergetics

Sónia A. Pinho; Paulo J. Oliveira; Teresa Cunha-Oliveira, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2025. https://doi.org/10.1016/j.bbadis.2024.167495 . 10.1016/j.bbadis.2024.167495 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Best Practices for Data Management and Sharing in Experimental Biomedical Research

Cunha-Oliveira, T.; Ioannidis, John P.A.; Oliveira, Paulo J., Physiological Reviews. 2024. http://dx.doi.org/10.1152/physrev.00043.2023 . 10.1152/physrev.00043.2023 . in press Physiological Reviews

Mitochondria: A Promising Convergent Target for the Treatment of Amyotrophic Lateral Sclerosis

Teresa Cunha-Oliveira; Liliana Montezinho; Rui F. Simões; Marcelo Carvalho; Elisabete Ferreiro; Filomena S. G. Silva, Cells. 2024. https://doi.org/10.3390/cells13030248 . 10.3390/cells13030248 . Cells

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Susana P. Pereira; Mariana S. Diniz; Ludgero C. Tavares; Teresa Cunha-Oliveira; Cun Li; Laura A. Cox; Mark J. Nijland; Peter W. Nathanielsz; Paulo J. Oliveira, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms242015192 . 10.3390/ijms242015192 . International Journal of Molecular Sciences

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Pinho, S.A.; Anjo, S.I.; Cunha-Oliveira, T., Antioxidants. 2023. https://www.mdpi.com/2076-3921/12/5/1072 . 10.3390/antiox12051072 . published Antioxidants

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints

Cunha-Oliveira, T.; Carvalho, Marcelo; Sardão, V.; Ferreiro, Elisabete; Mena, D.; Francisco B Pereira ; Borges, Fernanda; Oliveira, P.J.; Silva, Filomena, Research Square. 2022. https://www.researchsquare.com/article/rs-1196454/v1 . 10.21203/rs.3.rs-1196454/v1 . under revision Research Square

Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Pinho, Sónia A.; Costa, Cláudio F.; Deus, Cláudia M.; Pinho, Sonia L.C.; Miranda-Santos, Inês; Afonso, Gonçalo; Bagshaw, Olivia; et al, The FEBS Journal. 2022. http://dx.doi.org/10.1111/febs.16413 . 10.1111/febs.16413 . published The FEBS Journal

Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations

Cunha-Oliveira, T.; Silva, Daniela Franco; Segura, Luis; Baldeiras, Inês; Marques, Ricardo; Rosenstock, Tatiana; Oliveira, Paulo J.; Silva, Filomena S. G., European Journal of Clinical Investigation. 9. 52. 2022. http://dx.doi.org/10.1111/eci.13798 . 10.1111/eci.13798 . published European Journal of Clinical Investigation

Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics

Rui F. Simões; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, International Journal of Molecular Sciences. 3009 - 3009. 6. 23. 2022. https://doi.org/10.3390/ijms23063009 . 10.3390/ijms23063009 . International Journal of Molecular Sciences

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints

Cunha-Oliveira, Teresa; Carvalho, Marcelo; Sardão, Vilma; Ferreiro, Elisabete; Mena, Débora; Pereira, Francisco B.; Borges, Fernanda; Oliveira, Paulo J.; Silva, Filomena S. G., Molecular Neurobiology. 6373 - 6396. 10. 59. 2022. http://dx.doi.org/10.1007/s12035-022-02980-7 . 10.1007/s12035-022-02980-7 . published Molecular Neurobiology

NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells

Panieri, Emiliano; Pinho, Sónia A.; Afonso, Gonçalo J. M.; Oliveira, Paulo J.; Cunha-Oliveira, T.; Saso, Luciano, Cells. 15. 11. 2022. http://dx.doi.org/10.3390/cells11152401 . 10.3390/cells11152401 . published Cells

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Amorim, Ricardo; Simões, Inês C.M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al, Redox Biology. 55. 2022. http://dx.doi.org/10.1016/j.redox.2022.102400 . 10.1016/j.redox.2022.102400 . published Redox Biology

MPV17 mutations are associated with a quiescent energetic metabolic profile

Jacinto, Sandra; Guerreiro. Patrícia; Machado de Oliveira, Rita; Cunha-Oliveira, T.; Santos, Maria João; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago, Frontiers in Cellular Neuroscience. 2021. https://www.frontiersin.org/articles/10.3389/fncel.2021.641264/abstract . published Frontiers in Cellular Neuroscience

Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

Rui F. Simões; Rute Pino; Maurício Moreira-Soares; Jaromira Kovarova; Jiri Neuzil; Rui Travasso; Paulo J. Oliveira; Teresa Cunha-Oliveira; Francisco B. Pereira, The FASEB Journal. 12. 35. 2021. https://doi.org/10.1096/fj.202100899R . 10.1096/fj.202100899R . The FASEB Journal

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, Redox Biology. 2021. http://dx.doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . published Redox Biology

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Pereira, Susana P.; Tavares, Ludgero C.; Duarte, Ana I.; Baldeiras, Inês; Cunha-Oliveira, Teresa; Martins, João D.; Santos, Maria S.; et al, Clinical Science. 1103 - 1126. 9. 135. 2021. http://dx.doi.org/10.1042/cs20201339 . 10.1042/cs20201339 . published Clinical Science

Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Costa, C. F.; Pinho, S.A.; Pinho, S. L.; Miranda-Santos, I.; Bagshaw, O.; Stuart, J.; Oliveira, P.J.; # Cunha-Oliveira, T., BioRxiv. 2021. https://www.biorxiv.org/content/10.1101/2021.02.24.432508v1 . 10.1101/2021.02.24.432508 . published BioRxiv

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Simões, Rui F.; Ferrão, Rafaela; Silva, Margarida R.; Pinho, Sonia L. C.; Ferreira, Lino; Oliveira, Paulo J.; # Cunha-Oliveira, T., Food and Chemical Toxicology. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . published Food and Chemical Toxicology

Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Cunha-Oliveira, Teresa; Montezinho, Liliana; Mendes, Catarina; Firuzi, Omidreza; Saso, Luciano; Oliveira, Paulo J.; Silva, Filomena S. G., Oxidative Medicine and Cellular Longevity. 1 - 29. 2020. 2020. http://dx.doi.org/10.1155/2020/5021694 . 10.1155/2020/5021694 . published Oxidative Medicine and Cellular Longevity

Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity

Serafim, Teresa L.; * Cunha-Oliveira, Teresa; Deus, Claudia M.; Sardão, Vilma A.; Cardoso, Ines M.; Yang, Shanshan; Odhiambo, John F.; et al, European Journal of Clinical Investigation. 2. 51. 2020. http://dx.doi.org/10.1111/eci.13375 . 10.1111/eci.13375 . published European Journal of Clinical Investigation

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress

Ferreira, Leonardo M. R.; Cunha-Oliveira, Teresa; Sobral, Margarida C.; Abreu, Patrícia L.; Alpoim, Maria Carmen; Urbano, Ana M., International Journal of Molecular Sciences. 19. 20. 2019. http://dx.doi.org/10.3390/ijms20194901 . 10.3390/ijms20194901 . published International Journal of Molecular Sciences

Doxorubicin persistently rewires cardiac circadian homeostasis in mice

Ferreira, Luciana L.; Cervantes, Marlene; Froufe, Hugo J. C.; Egas, Conceição; Cunha-Oliveira, Teresa; Sassone-Corsi, Paolo; Oliveira, Paulo J., Archives of Toxicology. 2019. http://dx.doi.org/10.1007/s00204-019-02626-z . 10.1007/s00204-019-02626-z . published Archives of Toxicology

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease

Valdinocci, Dario; Simões, Rui F.; Kovarova, Jaromira; Cunha-Oliveira, Teresa; Neuzil, Jiri; Pountney, Dean L., Frontiers in Neuroscience. 13. 2019. http://dx.doi.org/10.3389/fnins.2019.00930 . 10.3389/fnins.2019.00930 . Frontiers in Neuroscience

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts

Ferreira, Luciana L.; Cunha-Oliveira, Teresa; Veloso, Caroline D.; Costa, Cláudio F.; Wallace, Kendall B.; Oliveira, Paulo J., Food and Chemical Toxicology. 450 - 461. 124. 2019. http://dx.doi.org/10.1016/j.fct.2018.12.017 . 10.1016/j.fct.2018.12.017 . published Food and Chemical Toxicology

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; et al, Cell Metabolism. 399 - 416.e10. 2. 29. 2019. http://dx.doi.org/10.1016/j.cmet.2018.10.014 . 10.1016/j.cmet.2018.10.014 . published Cell Metabolism

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells

Abreu, Patrícia L.; Cunha-Oliveira, Teresa; Ferreira, Leonardo M. R.; Urbano, Ana M., BioMetals. 477 - 487. 4. 31. 2018. http://dx.doi.org/10.1007/s10534-018-0093-7 . 10.1007/s10534-018-0093-7 . published BioMetals

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes

# Teresa Cunha-Oliveira; Luciana L. Ferreira; Ana Raquel Coelho; Cláudia M. Deus; Paulo J. Oliveira, Toxicology and Applied Pharmacology. 1 - 13. 348. 2018. https://doi.org/10.1016/j.taap.2018.04.009 . 10.1016/j.taap.2018.04.009 . published Toxicology and Applied Pharmacology

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity

Pereira, Susana P; Deus, Cláudia M; Serafim, Teresa L; Cunha-Oliveira, Teresa; Oliveira, Paulo J, Toxicological Sciences. 191 - 204. 1. 164. 2018. http://dx.doi.org/10.1093/toxsci/kfy068 . 10.1093/toxsci/kfy068 . published Toxicological Sciences

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Naia, Luana; * Cunha-Oliveira, Teresa; Rodrigues, Joana; Rosenstock, Tatiana R.; Oliveira, Ana; Ribeiro, Márcio; Carmo, Catarina; et al, The Journal of Neuroscience. 2776 - 2794. 10. 37. 2017. http://dx.doi.org/10.1523/jneurosci.2006-14.2016 . 10.1523/JNEUROSCI.2006-14.2016 . published The Journal of Neuroscience

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts

Coelho, Ana R.; Martins, Tatiana R.; Couto, Renata; Deus, Cláudia; Pereira, Cláudia V.; Simões, Rui F.; Rizvanov, Albert A.; et al, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2904 - 2923. 11. 1863. 2017. http://dx.doi.org/10.1016/j.bbadis.2017.07.030 . 10.1016/j.bbadis.2017.07.030 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, André; * Cunha-Oliveira, Teresa; Simões, Rui F.; Carvalho, Filipa S.; Burgeiro, Ana; Nordgren, Kendra; Wallace, Kendall B.; Oliveira, Paulo J., Toxicology. 63 - 73. 390. 2017. http://dx.doi.org/10.1016/j.tox.2017.08.011 . 10.1016/j.tox.2017.08.011 . published Toxicology

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, Ana Marta; Barbosa, Inês A.; Seabra, Cátia; Beltrão, Nuno; Santos, Raquel; Vega-Naredo, Ignacio; Oliveira, Paulo J.; # Cunha-Oliveira, Teresa, Food and Chemical Toxicology. 148 - 158. 1. 94. 2016. http://dx.doi.org/10.1016/j.fct.2016.06.001 . 10.1016/j.fct.2016.06.001 . published Food and Chemical Toxicology

Ketogenic diets: from cancer to mitochondrial diseases and beyond

Branco, Ana F.; Ferreira, André; Simões, Rui F.; Magalhães-Novais, Sílvia; Zehowski, Cheryl; Cope, Elisabeth; Silva, Ana Marta; et al, European Journal of Clinical Investigation. 285 - 298. 3. 46. 2016. http://dx.doi.org/10.1111/eci.12591 . 10.1111/eci.12591 . published European Journal of Clinical Investigation

Role of mtDNA-related mitoepigenetic phenomena in cancer

Ferreira, André; Serafim, Teresa L; Sardão, Vilma A; # Cunha-Oliveira, Teresa, European Journal of Clinical Investigation. 44 - 49. S1. 45. 2015. http://dx.doi.org/10.1111/eci.12359 . 10.1111/eci.12359 . published European Journal of Clinical Investigation

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Naia, Luana; Ferreira, I. Luísa; Cunha-Oliveira, Teresa; Duarte, Ana I.; Ribeiro, Márcio; Rosenstock, Tatiana R.; Laço, Mário N.; et al, Molecular Neurobiology. 331 - 348. 1. 51. 2015. http://dx.doi.org/10.1007/s12035-014-8735-4 . 10.1007/s12035-014-8735-4 . published Molecular Neurobiology

ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco, Ana F; Moreira, Ana C; Cunha-Oliveira, Teresa; Couto, Renata; Sardao, Vilma A; Rizvanov, Albert A; Palotas, Andras; et al, Current Drug Targets. 956 - 964. 10. 15. 2014. http://dx.doi.org/10.2174/1389450115666140902124230 . 10.2174/1389450115666140902124230 . published Current Drug Targets

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts

Moreira, Ana C; Branco, Ana F; Sampaio, Susana F; Cunha-Oliveira, Teresa; Martins, Tatiana R; Holy, Jon; Oliveira, Paulo J; et al, Biochimica et Biophysica Acta-Molecular Basis of Disease. 2468 - 2478. 12. 1842. 2014. http://hdl.handle.net/10316/41109 . 10.1016/j.bbadis.2014.09.015 . published Biochimica et Biophysica Acta-Molecular Basis of Disease

Oxidative Stress and Drugs of Abuse: An Update

# Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R., Mini-Reviews in Organic Chemistry. 321 - 334. 4. 10. 2013. http://dx.doi.org/10.2174/1570193X113106660026 . 10.2174/1570193X113106660026 . published Mini-Reviews in Organic Chemistry

Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., Life Sciences. 1157 - 1164. 24-26. 92. 2013. http://dx.doi.org/10.1016/j.lfs.2013.04.016 . 10.1016/j.lfs.2013.04.016 . published Life Sciences

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition

Bernardo, Telma C.; Cunha-Oliveira, Teresa; Serafim, Teresa L.; Holy, Jon; Krasutsky, Dmytro; Kolomitsyna, Oksana; Krasutsky, Pavel; Moreno, António M.; Oliveira, Paulo J., Bioorganic & Medicinal Chemistry. 7239 - 7249. 23. 21. 2013. http://dx.doi.org/10.1016/j.bmc.2013.09.066 . 10.1016/j.bmc.2013.09.066 . published Bioorganic & Medicinal Chemistry

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, Rita; * Cunha-Oliveira, Teresa; Rego, Ana Cristina, Free Radical Biology and Medicine. 186 - 201. 62. 2013. http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.042 . 10.1016/j.freeradbiomed.2013.05.042 . published Free Radical Biology and Medicine

Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria

# Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S., Toxicology Letters. 298 - 306. 3. 219. 2013. http://dx.doi.org/10.1016/j.toxlet.2013.03.025 . 10.1016/j.toxlet.2013.03.025 . published Toxicology Letters

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

Ribeiro, Márcio; Rosenstock, Tatiana R.; Cunha-Oliveira, Teresa; Ferreira, Ildete L.; Oliveira, Catarina R.; Rego, A. Cristina, Free Radical Biology and Medicine. 1857 - 1867. 10. 53. 2012. http://dx.doi.org/10.1016/j.freeradbiomed.2012.09.004 . 10.1016/j.freeradbiomed.2012.09.004 . published Free Radical Biology and Medicine

Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice

Pereira, Frederico C.; Cunha-Oliveira, Teresa; Viana, Sofia D.; Travassos, Ana S.; Nunes, Sara; Silva, Carlos; Prediger, Rui Daniel; et al, Neurotoxicology and Teratology. 522 - 529. 5. 34. 2012. http://dx.doi.org/10.1016/j.ntt.2012.07.005 . 10.1016/j.ntt.2012.07.005 . published Neurotoxicology and Teratology

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse

Perfeito, R.; * Cunha-Oliveira, T.; Rego, A.C., Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867397192&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.08.569 . Free Radical Biology and Medicine

Bioenergetic dysfunction in Huntington's disease human cybrids

Ferreira, I. Luisa; * Cunha-Oliveira, Teresa; Nascimento, Maria V.; Ribeiro, Márcio; Proença, M. Teresa; Januário, Cristina; Oliveira, Catarina R.; Rego, A. Cristina, Experimental Neurology. 127 - 134. 1. 231. 2011. http://dx.doi.org/10.1016/j.expneurol.2011.05.024 . 10.1016/j.expneurol.2011.05.024 . published Experimental Neurology

Neurotoxicity of heroin-cocaine combinations in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., Toxicology. 11 - 17. 1. 276. 2010. http://dx.doi.org/10.1016/j.tox.2010.06.009 . 10.1016/j.tox.2010.06.009 . published Toxicology

Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF

Almeida, Sandra; Cunha-Oliveira, Teresa; Laço, Mário; Oliveira, Catarina R.; Rego, A. Cristina, Neurotoxicity Research. 399 - 405. 4. 17. 2009. http://dx.doi.org/10.1007/s12640-009-9116-z . 10.1007/s12640-009-9116-z . published Neurotoxicity Research

BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons

Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C., Neurobiology of Disease. 448 - 456. 3. 35. 2009. http://dx.doi.org/10.1016/j.nbd.2009.06.006 . 10.1016/j.nbd.2009.06.006 . published Neurobiology of Disease

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Oliveira, Catarina R., Brain Research Reviews. 192 - 208. 1. 58. 2008. http://dx.doi.org/10.1016/j.brainresrev.2008.03.002 . 10.1016/j.brainresrev.2008.03.002 . Brain Research Reviews

Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., Journal of Neurochemistry. 543 - 554. 2. 101. 2007. http://dx.doi.org/10.1111/j.1471-4159.2006.04406.x . 10.1111/j.1471-4159.2006.04406.x . Journal of Neurochemistry

Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine

Cunha-Oliveira, T; Rego, AC; Macedo, T; Oliveira, CR, Free Radical Research. S22 - S22. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300068&KeyUID=WOS:000252296300068 . Free Radical Research

Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende, Toxicology. 54 - 62. 1. 217. 2006. http://dx.doi.org/10.1016/j.tox.2005.08.022 . 10.1016/j.tox.2005.08.022 . Toxicology

Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells

Domingues, A.; * Oliveira, T.C.; Laço, M.L.N.; Macedo, T.R.A.; Oliveira, C.R.; Rego, A.C., Annals of the New York Academy of Sciences. 458 - 465. 1074. 2006. http://dx.doi.org/10.1196/annals.1369.046 . 10.1196/annals.1369.046 . published Annals of the New York Academy of Sciences

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., Brain Research. 44 - 54. 1. 1089. 2006. http://dx.doi.org/10.1016/j.brainres.2006.03.061 . 10.1016/j.brainres.2006.03.061 . published Brain Research

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship

Milhazes, N.; Cunha-Oliveira, T.; Martins, P.; Garrido, J.; Oliveira, C.; Rego, A.C.; Borges, F., Chemical Research in Toxicology. 1294 - 1304. 10. 19. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209029&partnerID=MN8TOARS . 10.1021/tx060123i . Chemical Research in Toxicology

Efeito crónico da heroína e do peróxido de hidrogénio em células PC12

Cunha-Oliveira, Teresa; Rego, A Cristina; Morgadinho, M Teresa; Macedo, Tice R; Oliveira, Catarina R, Coimbra Médica V. 21 - 29. 1. 2. 2006. http://hdl.handle.net/10316/18520 . published Coimbra Médica V

Drugs of abuse induce apoptotic features in PC12 cells

Cunha-Oliveira, T.; Rego, A.C.; Macedo, T.; Oliveira, C.R., Annals of the New York Academy of Sciences. 667 - 670. 1. 1010. 2003. http://dx.doi.org/10.1196/annals.1299.121 . 10.1196/annals.1299.121 . published Annals of the New York Academy of Sciences

Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells

# Cunha-Oliveira, T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.R.A.; Oliveira, C.R., Annals of the New York Academy of Sciences. 487 - 496. 965. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036290212&partnerID=MN8TOARS . 10.1111/j.1749-6632.2002.tb04190.x . published Annals of the New York Academy of Sciences

All projects

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Information of exclusive responsibility of the researcher 03-11-2024 , from platform CIÊNCIAVITAE.

2023/03/01 -

EXCELScIOR: EXCELlent Science with Impact, Open and Reliable

101087416

Researcher

Universidade de Coimbra

Funders: Horizon Europe

2023/05 -

PAS GRAS - De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults

101080329

Researcher

Funders: European Commission

2022/01/15 - 2025/01/14

Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis

PTDC/BTM-ORG/0055/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2022/01/01 - 2023/06/30

Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis

EXPL/BTM-TEC/1407/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2022 - 2023/06/30

Mitochondria as potential drivers of sex-specific microglia dysfunctional remodelling and anxiety caused by prenatal stress

EXPL/MED-NEU/1002/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/03/29 - 2024/03/28

SYNAPTIC VESICLE MATURATION AND ITS RELEVANCE FOR NEURODEGENERATION

PTDC/MED-NEU/8030/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2023/12/31

Organelle-targeted Radiocomplexes for Auger Therapy of Cancer

PTDC/MED-QUI/1554/2020

Researcher

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2019/02/01 - 2025/01/31

MitoProfiling- Mitochondrial Health Profiling. Applications in Toxicology and Personalized Medicine

DL 57/2016/CP1448/CT0016

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/09/01 - 2019

Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside

PEPITA2018

Researcher

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2018/05/01 - 2021/04/30

Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype

PTDC/MED-FAR/29391/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade do Porto

Funders: Fundação para a Ciência e a Tecnologia

2018/07/06 - 2021/12/05

Development and validation of innovative screening methods for mitochondrial health modulators

PTDC/BTM-SAL/29297/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2015/01/01 - 2017

An Epigenetic Engineering Approach to Reverse the Parkinson Disease Cell State

Montepio_CNC

Researcher

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundação Montepio

2015/10 - 2018/09

EXERCISING THE FUTURE: Voluntary Exercise During Gestational Diabetes as a Means to Improve Mitochondrial Function in the Offspring

grant.Provided by PTCRIS: 139707

Researcher

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundacao para a Ciencia e a Tecnologia

2015/10 - 2018/09

MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria

grant.Provided by PTCRIS: 141059

Researcher

Funders: Fundacao para a Ciencia e a Tecnologia

2014/03/01 - 2015/09/30

Stemcell based platforms for regenerative and therapeutic medicine

CENTRO-07-ST24-FEDER-002008

Post-doc Fellow

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: European Regional Development Fund

2013/12/01 - 2014/02/28

Role of mitochondrial p66Shc in drug-induced mitochondrial toxicity memory

grant.Provided by PTCRIS: 117912

Post-doc Fellow

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundacao para a Ciencia e a Tecnologia

2013/05 - 2016/04

Pathophysiology of Persistent Doxorubicin Cardiotoxicity: a Mitochondrial-Epigenetics Link

PTDC/DTP-FTO/1180/2012

Researcher

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundacao para a Ciencia e a Tecnologia

2012/09/01 - 2013

Alpha-synuclein modifications in peripheral blood lymphocytes from sporadic and familial Parkinson's disease patients

PDCR02

Researcher

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2008/09 - 2010/08

Relationship Between Body Weight and the Development of Heroin Addiction: Role of Insulin and Leptin Hypothalamic Signalling Pathways

grant.Provided by PTCRIS: 126115

Principal investigator

Funders: Instituto de Investigação Interdisciplinar, Universidade de Coimbra

2005/07 - 2008/06

Biochemical and Behavioural Study of Opioid-Cocaine Interactions

grant.Provided by PTCRIS: 58330

Researcher

Centro de Neurociências e Biologia Celular da Universidade de Coimbra

Funders: Fundacao para a Ciencia e a Tecnologia

2004/09/01 - 2005

Contribution of different subunits of the NMDA receptor to heroin cytotoxicity

GAI/06/2004

Researcher

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

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