Paulo Cesar da Silva Pinheiro

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Researcher

Synapse Biology

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy

Pinheiro, PS, Frontiers in Neuroscience. 14. 2021. http://dx.doi.org/10.3389/fnins.2020.578409 . 10.3389/fnins.2020.578409 . Frontiers in Neuroscience

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

Tawfik, Bassam; Martins, Joana S; Houy, Sébastien; Imig, Cordelia; Pinheiro, Paulo S; Wojcik, Sonja M; Brose, Nils; Cooper, Benjamin H; Sørensen, Jakob Balslev, eLife. 10. 2021. http://dx.doi.org/10.7554/elife.64527 . 10.7554/elife.64527 . eLife

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

Gowrisankaran, Sindhuja; Houy, Sébastien; del Castillo, Johanna G. Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.; et al, Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-14993-8 . 10.1038/s41467-020-14993-8 . Nature Communications

Rhythmic and synchronized neuronal activity in primary hippocampal cultures incubated transiently in the absence of magnesium: characterization as an in vitro model of epilepsy

Miranda Mele; Ricardo Vieira; Barbara Correia; Filipe V. Duarte; Pinheiro, PS; Carlos B. Duarte, Epilepsia. 2020. submitted Epilepsia

Chronic Hyperglycemia Impairs Hippocampal Neurogenesis and Memory in an Alzheimer’s disease mouse model

Ferreiro, Elisabete; Lanzillo, Mariagrazia; Canhoto, Diogo; Carvalho da Silva, António M.; Mota, Sandra I.; Dias, Inês S.; Ferreira, Ildete L.; et al, Neurobiology of Aging. 2020. http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003 . 10.1016/j.neurobiolaging.2020.04.003 . Neurobiology of Aging

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte, Science Signaling. eaav3577 - eaav3577. 586. 12. 2019. https://doi.org/10.1126/scisignal.aav3577 . 10.1126/scisignal.aav3577 . Science Signaling

GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons

Mele, M.; De Luca, P; Santos, AR; Vieira, M; Pinheiro, PS; Duarte CB, The FASEB Journal. 2019. under revision The FASEB Journal

Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia

Agís-Balboa, R.C.; Pinheiro, P.S.; Rebola, N.; Kerimoglu, C.; Benito, E.; Gertig, M.; Bahari-Javan, S.; et al, EMBO Journal. 2815 - 2828. 19. 36. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026640250&partnerID=MN8TOARS . 10.15252/embj.201796821 . EMBO Journal

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Walter, A.M.; Müller, R.; Tawfik, B.; Wierda, K.D.; Pinheiro, P.S.; Nadler, A.; McCarthy, A.W.; et al, eLife. 6. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049410553&partnerID=MN8TOARS . 10.7554/eLife.30203 . eLife

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

Houy S; Groffen AJ; Ziomkiewicz I; Verhage M; Pinheiro PS; Sørensen JB; Houy, S.; et al, eLife. 6. 2017. http://europepmc.org/abstract/med/29274147 . 10.7554/elife.27000 . eLife

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.

Leal G; Comprido D; de Luca P; Morais E; Rodrigues L; Mele M; Santos AR; et al, eNeuro. 2017. http://europepmc.org/abstract/med/29255796 . 10.1523/eneuro.0268-17.2017 . eNeuro

The RNA-binding protein hnRNP K mediates the effect of BDNF on dendritic mRNA metabolism and regulates synaptic NMDA receptors in hippocampal neurons

Leal, G.; Comprido, D.; de Luca, P.; Morais, E.; Rodrigues, L.; Mele, M.; Santos, A.R.; et al, eNeuro. 6. 4. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85039718465&partnerID=MN8TOARS . 10.1523/ENEURO.0268-17.2017 . eNeuro

C2-domain Containing Calcium Sensors in Neuroendocrine Secretion.

Pinheiro PS; Houy S; Sørensen JB, 2016. http://europepmc.org/abstract/med/27731902 . 10.1111/jnc.13865 .

Regulation of Ca<sup>2+</sup>channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters

Toft-Bertelsen, T.L.; Ziomkiewicz, I.; Houy, S.; Pinheiro, P.S.; Sorensen, J.B., Molecular Biology of the Cell. 3329 - 3341. 21. 27. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994259455&partnerID=MN8TOARS . 10.1091/mbc.E16-03-0184 . Molecular Biology of the Cell

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

Man KN; Imig C; Walter AM; Pinheiro PS; Stevens DR; Rettig J; Sørensen JB; et al, eLife. NOVEMBER20. 4. 2015. http://europepmc.org/abstract/med/26575293 . 10.7554/elife.10635 . eLife

Spatial distribution and temporal evolution of DRONPA-fused SNAP25 clusters in adrenal chromaffin cells

Yasuko Antoku; Peter Dedecker; Paulo S. Pinheiro; Tom Vosch; Jakob Balslev Sørensen, Photochem. Photobiol. Sci.. 2015. http://dx.doi.org/10.1039/c4pp00423j . 10.1039/c4pp00423j . Photochem. Photobiol. Sci.

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells

Pinheiro, P.S.; Jansen, A.M.; de Wit, H.; Tawfik, B.; Madsen, K.L.; Verhage, M.; Gether, U.; Sørensen, J.B., Journal of Neuroscience. 10688 - 10700. 32. 34. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905715514&partnerID=MN8TOARS . 10.1523/JNEUROSCI.5132-13.2014 . Journal of Neuroscience

Zinc dynamics and action at excitatory synapses

Vergnano, A.M.; Rebola, N.; Savtchenko, L.P.; Pinheiro, P.S.; Casado, M.; Kieffer, B.L.; Rusakov, D.A.; Mulle, C.; Paoletti, P., Neuron. 1101 - 1114. 5. 82. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901768895&partnerID=MN8TOARS . 10.1016/j.neuron.2014.04.034 . Neuron

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering

Mohrmann, R.; de Wit, H.; Connell, E.; Pinheiro, P.S.; Leese, C.; Bruns, D.; Davletov, B.; Verhage, M.; Sørensen, J.B., Journal of Neuroscience. 14417 - 14430. 36. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883430611&partnerID=MN8TOARS . 10.1523/JNEUROSCI.1236-13.2013 . Journal of Neuroscience

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion

Walter, A.M.; Pinheiro, P.S.; Verhage, M.; Sørensen, J.B., PLoS Computational Biology. 12. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892688353&partnerID=MN8TOARS . 10.1371/journal.pcbi.1003362 . PLoS Computational Biology

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release

Pinheiro, P.S.; de Wit, H.; Walter, A.M.; Groffen, A.J.; Verhage, M.; Sørensen, J.B., Journal of Neuroscience. 16459 - 16470. 42. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885441178&partnerID=MN8TOARS . 10.1523/JNEUROSCI.2656-13.2013 . Journal of Neuroscience

Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses

Pinheiro, P.S.; Lanore, F.; Veran, J.; Artinian, J.; Blanchet, C.; Crépel, V.; Perrais, D.; Mulle, C., Cerebral Cortex. 323 - 331. 2. 23. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872315470&partnerID=MN8TOARS . 10.1093/cercor/bhs022 . Cerebral Cortex

The GluK3 Ligand Binding Domain has a Zinc Binding Site at the Dimer Interface

Janesh Kumar; Julien Veran; Paulo S. Pinheiro; Axel Athane; David Perrais; Christophe Mulle; Mark L. Mayer, Biophysical Journal. 272a - 272a. 2. 104. 2013. https://doi.org/10.1016%2Fj.bpj.2012.11.1526 . 10.1016/j.bpj.2012.11.1526 . Biophysical Journal

Therapeutic potential of metabotropic glutamate receptor modulators

Hovelsø, N.; Sotty, F.; Montezinho, L.P.; Pinheiro, P.S.; Herrik, K.F.; Mørk, A., Current Neuropharmacology. 12 - 48. 1. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857705629&partnerID=MN8TOARS . 10.2174/157015912799362805 . Current Neuropharmacology

Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface

Veran, J.; Kumar, J.; Pinheiro, P.; Athané, A.; Mayer, M.; Perrais, D.; Mulle, C., Neuron. 565 - 578. 3. 76. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868660479&partnerID=MN8TOARS . 10.1016/j.neuron.2012.08.027 . Neuron

Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon

Lanore, F.; Blanchet, C.; Fejtova, A.; Pinheiro, P.; Richter, K.; Balschun, D.; Gundelfinger, E.; Mulle, C., Journal of Physiology. 2133 - 2145. 12. 588. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954626422&partnerID=MN8TOARS . 10.1113/jphysiol.2009.184929 . Journal of Physiology

Antagonism of recombinant and native GluK3-containing kainate receptors

Perrais, D.; Pinheiro, P.S.; Jane, D.E.; Mulle, C., Neuropharmacology. 131 - 140. 1. 56. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049104342&partnerID=MN8TOARS . 10.1016/j.neuropharm.2008.08.002 . Neuropharmacology

Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus

Araújo, I.M.; Gil, J.M.; Carreira, B.P.; Mohapel, P.; Petersen, Å.; Pinheiro, P.S.; Soulet, D.; et al, Journal of Neurochemistry. 666 - 676. 3. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42449116702&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05181.x . Journal of Neurochemistry

Presynaptic glutamate receptors: physiological functions and mechanisms of action.

Pinheiro, P.S.; Mulle, C., Nature reviews. Neuroscience. 423 - 436. 6. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949104175&partnerID=MN8TOARS . 10.1038/nrn2379 . Nature reviews. Neuroscience

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses

Pinheiro, P.S.; Perrais, D.; Coussen, F.; Barhanin, J.; Bettler, B.; Mann, J.R.; Malva, J.O.; Heinemann, S.F.; Mulle, C., Proceedings of the National Academy of Sciences of the United States of America. 12181 - 12186. 29. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547511221&partnerID=MN8TOARS . 10.1073/pnas.0608891104 . Proceedings of the National Academy of Sciences of the United States of America

Kainate receptors

Pinheiro, P.; Mulle, C., Cell and Tissue Research. 457 - 482. 2. 326. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748932824&partnerID=MN8TOARS . 10.1007/s00441-006-0265-6 . Cell and Tissue Research

Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses

Pinheiro, P.S.; Rodrigues, R.J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., Neurochemistry International. 309 - 316. 5. 47. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS . 10.1016/j.neuint.2005.05.007 . Neurochemistry International

Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats

Silva, A.P.; Xapelli, S.; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; et al, Journal of Neurochemistry. 163 - 170. 1. 93. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144388681&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.03005.x . Journal of Neurochemistry

Proteolysis of NR2B by calpain in the hippocampus of epileptic rats

Araújo, I.M.; Xapelli, S.; Gil, J.M.A.C.; Mohapel, P.; Petersén, Å.; Pinheiro, P.S.; Malva, J.O.; et al, NeuroReport. 393 - 396. 4. 16. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144387582&partnerID=MN8TOARS . 10.1097/00001756-200503150-00017 . NeuroReport

Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus

Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A., Brain Research. 49 - 58. 1. 987. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS . 10.1016/S0006-8993(03)03247-5 . Brain Research

Adenosine A3 receptors are located in neurons of the rat hippocampus

Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., NeuroReport. 1645 - 1648. 12. 14. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS . 10.1097/00001756-200308260-00021 . NeuroReport

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., Neuroscience Letters. 97 - 100. 2. 336. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS . 10.1016/S0304-3940(02)01217-X . Neuroscience Letters

Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures.

Silva, A.P.; Pinheiro, P.S.; Carvalho, A.P.; Carvalho, C.M.; Jakobsen, B.; Zimmer, J.; Malva, J.O., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1118 - 1120. 9. 17. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037704392&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

All projects

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2021/01/01 - 2023/12/31

mStar - Potassium channel dysfunction in models of neurodevelopmental disorders

HR20-00904

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Obra Social La Caixa

2021/01/01 -

Synaptic vesicle maturation and its relevance for neurodegeneration

PTDC/MED-NEU/8030/2020

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019/09/26 -

Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders

info:eu-repo/grantAgreement/EC/H2020/813986/EU

Principal investigator

CNC.IBILI

Funders: EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions

2018/07/01 - 2021/06/30

COGNITIVE DISORDERS AS DEFECTS IN SYNAPTIC FUNCTION: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE

PTDC/MED-NEU/28541/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2020

BrainHealth 2020: Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias

CENTRO-01-0145-FEDER-000008

Supervisor

Universidade de Coimbra

Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro; European Commission

2018/10 - 2021/09

Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction

PTDC/BIA-CEL/29451/2017

Principal investigator

CNC.IBILI

Funders: Foundation for Science and Technology (Lisbon)

2016 - 2016

IBRO/FENS travel grant

N/A

Funders: International Brain Research Organization

2014 -

A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity

PTDC/NEU-NMC/4888/2014

Funders: Fundação para a Ciência e a Tecnologia

2013/10 - 2018/09

Role of distinct synaptotagmin isoforms in exocytosys and neuronal function

IF/01302/2012

Funders: Fundação para a Ciência e a Tecnologia

2013/10 - 2018/09

Role of distinct synaptotagmin isoforms in exocytosys and neuronal function

IF/01302/2012

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011 - 2012

Marie Curie Fellowship - Exosyts

PIEF-GA-2009-254647

Principal investigator

Københavns Universitet

Funders: European Commission

2010/01 - 2014/12

Synaptotagmin isoformer og deres funktion i neurotransmitter-frisættelsen

R34-A3740

Principal investigator

Københavns Universitet

Funders: Lundbeckfonden

2010/07 - 2014/12

synSys - Synaptic Systems: dissecting brain function in health and disease

H-2009-242167

Funders: European Commission

2007 - 2009

Le zinc synaptique : un modulateur endogène de la neurotransmission excitatrice?

ANR-07-NEUR-0044

Researcher

Centre National de la Recherche Scientifique

Funders: Agence nationale de la recherche

2006/05/01 - 2008/04/30

Role of mossy fiber synapse kainate receptors in synaptic transmission and plasticity

SFRH/BPD/23314/2005

Post-doc Fellow

Institut Interdisciplinaire de Neurosciences

Funders: Fundação para a Ciência e a Tecnologia

2005 - 2007

Récepteurs kaïnate présynaptiques: fonctions, mécanismes et trafic polarizé

ANR-05-NEUR-0033

Researcher

Funders: Agence nationale de la recherche

2005/12 - 2009/12

From molecules to networks: understanding synaptic physiology and pathology of the brain through mouse models

LSH-2004-019055

Funders: European Commission

2004 -

Zinc excitotoxicity in organotypic hippocampal slice cultures

FEBS short-term fellowship

PhD Student Fellow

Biologisk Institut Syddansk Universitet

2004 -

Zinc excitotoxicity in organotypic hippocampal slice cultures

Calouste Gulbenkian short-term fellowship

PhD Student Fellow

Biologisk Institut Syddansk Universitet

2002 - 2005

Neuroprotective effect of NPY in excitotoxicity and temporal lobe epilepsy

POCTI/NSE/46848/2002

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2002 - 2005

Immunological and functional identification of ionotropic presynaptic glutamate receptors

FCB/46804/2002

Funders: Fundação para a Ciência e a Tecnologia

2001/10/01 - 2006/01/19

Presynaptic kainate receptors in the hippocampus: Essential role for the glur7 subunit at mossy fiber synapses in the hippocampus

SFRH/BD/5319/2001

PhD Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2000/10 - 2001/09

12 months Grant for Initiation to Scientific Research

n/a

Integration into Research Grant Fellow

2000/10 - 2001/09

12 months Grant for Initiation to Scientific Research

n/a

Integration into Research Grant Fellow

1999 - 2002

Mechanisms of presynaptic kainate receptor inhibition of glutamate and GABA release: role in epileptogenesis

POCTI/1999/BCI/36491

Funders: Fundação para a Ciência e a Tecnologia

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